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Articles 301 - 303 of 303
Full-Text Articles in Medicine and Health Sciences
Synthesis Of A New Scytovirin Protein Derivative, Sd1-Sd2-Sd2, To Decrease Hiv-1 Binding Affinity, Alexandra M. Wood
Synthesis Of A New Scytovirin Protein Derivative, Sd1-Sd2-Sd2, To Decrease Hiv-1 Binding Affinity, Alexandra M. Wood
Honors Theses
Scytovirin is a novel anti-viral protein isolated from the cyanobacterium Scytonema varium. This protein has produced great scientific interest for its anti-human immunodeficiency virus (HIV) activity. Scytovirin disrupts the mechanism of HV infection by binding to HIV-1 proteins glycoprotein 120, glycoprotein 160, and glycoprotein 41. It does not bind to the CD4 receptor on human immune cells. The wild-type protein consists of a single 95 amino acid chain. When folded, Scytovirin's amino acid sequence is arranged into two distinct domains, each with a high degree of sequence conservation. This implicates the importance of both domains in anti-HIV activity. Primers were …
Mechanism Of Action Of A Novel Antifungal Compound, Amber Ward
Mechanism Of Action Of A Novel Antifungal Compound, Amber Ward
Honors Theses
Opportunistic fungal infections have become problematic in recent years. There has been an emergence of new fungal pathogens, development of antifungal resistance, and increasing prevalence. In addition, toxicity, resistance, and lack of efficacy as a single agent limit the effectiveness of current antifungal drugs. Therefore, new drugs targeting new pathways are greatly needed. An analog derived from the marine natural product phloeodictine, analog PHL5-34A, was identified as having strong in vitro antifungal activity. In this study, its mechanism of action (MOA) was investigated in the model yeast, Saccharomyces cerevisiae. This study made use of a collection of 166 yeast mutants …
Pharmacists' Perceptions Of Practice Roles: Opportunities And Challenges Facing Pharmacy With Respect To Expanding The Scope Of Practice In Mississippi, Peter John Pattridge Jr.
Pharmacists' Perceptions Of Practice Roles: Opportunities And Challenges Facing Pharmacy With Respect To Expanding The Scope Of Practice In Mississippi, Peter John Pattridge Jr.
Honors Theses
Title: Pharmacists' Perceptions of Practice Roles: Opportunities and Challenges Facing Pharmacy with Respect to Expanding the Scope of Practice in Mississippi Objective: To provide objective evidence as to the opportunities and challenges that pharmacists will encounter when implementing an expanded role in the health care system from the perspective of the practicing pharmacist. Methods: Questionnaires were mailed to Mississippi licensed pharmacists. The first section contained questions dealing with the demography of the respondent including a utilization of skills scale and several domains of job satisfaction. The second section contained the health care activities inventory. Respondents were asked to report which …