Medicine and Health Sciences Commons^™

Interaction Between Fluoxetine And Risperidone And Its Association With Clinical Outcomes In Schizophrenic Patients, Fitri Rachmaini, Dian Ayu Juwita, Rahmad Abdillah, Rezy Dwi Afrianti, Fatma Sri Wahyuni

Pharmaceutical Sciences and Research

The concurrent use of fluoxetine and risperidone to treat schizophrenia may result in drug interactions. This study aims to analyse the clinical outcomes of fluoxetine-risperidone therapy and the possibility of their interaction in schizophrenic patients. The clinical outcomes are patient status at the time of hospital discharge, the length of hospitalisation and the Positive and Negative Syndrome Scale- Excitement Component (PANSS-EC). This study was conducted prospectively in psychiatric ward of HB Saanin Mental Hospital from May to October 2021 and study subjects were selected using consecutive sampling technique with inclusion criteria. Forty-three patients were eligible for this study. Research data …

Beyond Use Date (Bud) Determination Of Ambroxol Hydrochloride Syrup By High-Performance Liquid Chromatography – Uv/Vis Detector, Catur Jatmika, Raditya Iswandana, Indah Dewi Lestari

Pharmaceutical Sciences and Research

Ambroxol HCl is a mucolytic agent often used to treat respiratory disorders associated with excess mucus secretion. This study aims to determine the beyond-use date (BUD) of ambroxol HCl syrup on the market based on analysis of the decrease in drug content using High-Performance Liquid Chromatography (HPLC) – UV/Vis detector. The HPLC conditions were reversed-phase with a C18 column, mobile phase containing acetonitrile - phosphate buffer 0.05 M pH 4.5 (60:40) at a flow rate of 1.0 ml/min using UV detection at 248 nm. To determine BUD, five syrup preparations (brands) obtained from the Jakarta area were analyzed in triplicate. …

Synthesis Of Ferrous Fumarate From Indonesian Iron Sand And In Vivo Body Weight Gain Test In Rats, Taufiq Indra Rukmana, Felicia Natalia Kurniadi, Harmita Harmita

Pharmaceutical Sciences and Research

Iron deficiency anemia (IDA) is a health problem in Indonesia. Prevention and treatment of IDA is carried out by giving fortified foods and oral iron therapy. Both can use ferrous fumarate which is made with reacting bivalent iron and disodium fumarate. Bivalent iron can be obtained from iron sand in Indonesia. This study aims to synthesize ferrous fumarate from Indonesian iron sand, which is from Malang, Sukabumi, and Cianjur area, and to determine its absorption through in vivo body weight gain test in male Wistar white rats (Rattus norvegicus). First, ferrous fumarate was synthesized through reaction of ferrous …

Utilization Of Spent Arabica Coffee Grounds As Raw Material For Activated Charcoal In Liquid Bath Soap Formulation, Hilda Maysarah, Lydia Septa Desiyana, Siti Nurzuhra, Didi Nurhadi Illian

Pharmaceutical Sciences and Research

Arabica coffee (Coffea arabica) is one of the most popular coffees among Acehnese, an ethnic group from Aceh, Indonesia. The amount of coffee consumed is directly proportional to the amount of coffee waste produced. Spent coffee grounds are the residue obtained during the brewing process. Spent coffee grounds can be utilized by converting them into active charcoal adsorbents. This study aimed to produce activated charcoal from spent arabica coffee grounds (SACG), to utilize it as an active ingredient in the liquid bath soap formulations, and to determine the best formula. The characterization of activated charcoal was conducted and …

Solid Dispersion Technology For Improving The Solubility Of Antiviral Drugs, Maria Elvina Tresia Butar-Butar, Nasrul Wathoni, Hestiary Ratih, Yoga Windhu Wardhana

Pharmaceutical Sciences and Research

Most drugs, including antiviral drugs, show low solubility in water, which affects dissolution, bioavailability, and therapeutic effectiveness. Therefore, many antiviral drugs are given in very large doses. One of the efforts to overcome these problems is the application of solid dispersions in which polymers and surfactants can trap drug molecules that are in the amorphous phase. Drugs in a hydrophilic carrier will increase wettability, water absorption capacity, and porosity of particles, so that the drug is released better. This review article will discuss the development of technology in solid-state, how solid dispersion overcomes the lack of solubility and the rate …

Health And Nutritional Status Among Internally Displaced Children Under Five Years, During The Civil War: Sri Lankan Experience, Madhuka Ambagahage

Indonesian Journal of Public Health Nutrition (IJPHN)

Around the globe, 1 in 6 children become vulnerable to grave physical and mental violence, hunger, sexual assaults, and exploitation of human rights due to war. These adversities are multi-dimensional, synergistic, and often subtle. This study attempted to evaluate the health and nutritional status of children aged under five years and living in the war zone of Sri Lanka, in view of improving the health services delivered to them. The study used a descriptive cross-sectional design. The study sample, 400, was based on probability proportionate and then systematic sampling drawn from IDP camps located in the Vavuniya district. Validated instruments …

The Effectiveness Of Nem (Nutrizone Educational Media) Compared With Knowledge And Attitudes In Early Adults In The West Jakarta Region, Daniel Hartanto, Laras Sitoayu, Lintang Purwara Dewanti, Harna Harna, Mertien Sa’Pang

Indonesian Journal of Public Health Nutrition (IJPHN)

Metabolic syndrome is a disease that often occurs in early adulthood. Maintaining a good lifestyle to prevent non-communicable diseases is very important to maintain a good quality of life. In early adulthood, most of them are still not exposed to information related to metabolic syndrome, so it is necessary to provide interventions associated with it. This study uses the Nutrizone gameboard intervention media. Good early adults’ knowledge and attitude about Metabolic Syndrome may lead to a good lifestyle that prevents them from suffering from NCDs. An intervention media may improve their knowledge and attitude. The research design used was pre-experimental …

Dietary Determinants Of Stunting And Underweight In Under- Five Years Children In Pengasinan Health Center's (Puskesmas) Working Area, Depok, West Java, Muthia Syifa Rahmadina, Ratih Qamara Dewi, Arif Hidayat, Satria Yudistira, Fadila Wirawan

Indonesian Journal of Public Health Nutrition (IJPHN)

Stunting and underweight are public health problems, especially in under-five children. This study aims to explore the dietary determinants of stunting and underweight. Participants were 52 under-five children who visited Posyandu in Pengasinan and Bedahan, Depok. Body weight for age z-score (WAZ) and height for age z-score (HAZ) were measured with standardized measurement tools by trained operators. Questionnaires were administered to determine sociodemographic, maternal, and child health history, sanitation, disease history, and exclusive breastfeeding history. Data on food intake was obtained through the semi-quantitative Food Frequency Questionnaire and 24-hour recall. There was a significant correlation between the mother’s income with …

Factors Related To The Incidence Of Diarrhea Of Children Aged 24-59 Months In Karangkamulyan Village, Cihara District, Lebak Regency In 2020, Hafshah Farah Fadhilah, Kusharisupeni Djokosujono, Ratu Ayu Dewi Sartika

Indonesian Journal of Public Health Nutrition (IJPHN)

Diarrhea remains a major issue in developing countries, including Indonesia, and is a leading cause of malnutrition and death. Banten is one of the provinces with a high incidence of diarrhea. In 2019, the district with the highest number of diarrhea cases for all ages in Banten was Lebak with a total of 50,270 cases. The age group with the greatest number of diarrhea cases was toddlers with over 14,000 cases. This study aimed to investigate the relationship between the incidence of diarrhea and the characteristics of toddlers and their parents, personal hygiene, and environmental sanitation. The study used secondary …

Analysis Of Energy Balance In Obese Healthcare Workers, Nani Cahyani Sudarsono, Ria Lestari, Tiffany Georgine T’Sidkenu Widjaja

Indonesian Journal of Public Health Nutrition (IJPHN)

Obesity is a global health challenge that seriously affects developing countries, including Indonesia. It is important to discover the energy balance calculated from energy intake and energy expenditure in obese individuals, especially in obese healthcare workers. This study aimed to analyze the balance of energy intake and expenditure, body composition, and physical activity level in obese healthcare workers at the Exercise Center of Indonesia Medical Education and Research Institute (IMERI FKUI). A cross-sectional study was held at Exercise Center IMERI FKUI. Total sampling was the sampling method utilized in the study. Study participants (aged above 18 years) were screened by …

Associated Food Parenting Practices And Other Factors With Fruit And Vegetable Consumption In Students In Jakarta, Indonesia, Gina Amalia Chaerunnisa, Triyanti Triyanti

Indonesian Journal of Public Health Nutrition (IJPHN)

The increased risk of non-communicable diseases is still a problem in Indonesia, one of which is the lack of consumption of fruits and vegetables. The available data shows that although fruits and vegetables have a protective/protective effect on the incidence of non-communicable diseases but in real life, the average consumption of fruits and vegetables is still below the recommended intake. Thus, the protective effect cannot be seen clearly. This study aims to describe the consumption of fruits and vegetables and determine the factors of food parenting practices and other factors related to the consumption of fruits and vegetables in students …

Comparison Of Maturation Stages Of Natural Killer Cell Differentiation Culture From Cultured And Freshly Isolated Umbilical Cord Blood Hematopoietic Stem Cells, Samuel Febrian Wijaya, Retno Lestari, Inna Rahmawati, Imelda Rosalyn Sianipar, Robby Nuraditya, Iqbal Fasha, Gita Pratama, Radiana Dhewayani Antarianto

Makara Journal of Health Research

Background: Natural killer (NK) cells originate from the differentiation of hematopoietic stem cells (HSCs) in the common lymphoid progenitor pathway, and HSCs can be obtained from umbilical cord blood (UCB). Comparative studies of NK cell differentiation between cultured and freshly isolated HSCs are important in the development of NK cell therapy for cancer. This study aimed to compare the maturation stages of NK cell differentiation between cultured and newly isolated HSC samples using interleukin-2 in the absence of feeder cells.

Methods: Differentiation cultures were divided into two groups according to HSC source. Giemsa staining and flow cytometry were …

Nurses’ Perception Of Work-Environment Uncertainty And Readiness For Organizational Change, Aishah Alsolami, Hanan Alkorashy, Mysara Alfaki, Ahmed Alkarani

Makara Journal of Health Research

Background: Healthcare organizations have a dynamic work-environment that changes constantly. This study aimed to explore whether there is a relationship between work-environment uncertainty and nurses’ readiness to participate in organizational change.

Methods: A cross-sectional study was conducted at two tertiary hospitals. The sample size was 222 nurses. A self-report questionnaire was adopted, translated to Arabic, and used for collecting data; it consists of three scales, personal data sheet, organizational readiness for implementing change scale, and perceived environmental uncertainty in hospitals scale. Descriptive statistics t-test and analysis of variance were used to analyze the data.

Results: The level …

Unmet Need For Family Planning In Indonesia And Its Associated Factors, Dewi Nuryana, Restu Adya Cahyani, Sukma Rahayu, Nohan Arum Romadlona, Elvira Liyanto, Lovely Daisy, Wira Hartiti, Maria Evi Ratnawati, Budi Utomo, Robert Joseph Magnani

Makara Journal of Health Research

Background: The unmet need for family planning in Indonesia has been stagnant since the early 2000s in the 10%–12% range with substantial socioeconomic and geographic disparities. This study sought to better understand the factors underlying the nonuse of contraceptives among women with an apparent need for family planning so that evidence-based corrective actions can be taken.

Methods: Three sources of quantitative data were used in the study—the 2017 Indonesia Demographic Health Survey, the 2018 Village Potential Survey, and the National Population and Family Planning Board service statistics. Further insights were obtained from online focus group discussions and in-depth …

Protective Effect Of Betulinic Acid Administration On Kidney Damage In Acetaminophen-Induced Nephrotoxicity Model, Eda Dokumacioglu, Hatice İskender, Armagan Hayirli, Guler Yenice, Kubra Asena Terim Kapakin, Ismail Bolat, Esra Manavoglu Kirman

Makara Journal of Health Research

Background: Acetaminophen (APAP) is the most widely used analgesic drug worldwide, but it may induce renal toxicity. Betulinic acid (BA) ameliorates the oxidative stress and inflammatory response to renal damage. The present study aimed to investigate the potential protective effects of BA treatment through an experimental kidney damage rat model administered with APAP.

Methods: Sprague–Dawley male rats were randomly divided into four groups: control, BA (25 mg/kg for 15 days), APAP (1 g/kg), and APAP + BA groups. BA was administered via oral gavage at a dose of 25 mg/kg for 15 days. APAP was dissolved in hot …

Undergraduate Student Nurses’ Attitude Toward Mental Health Education: A Cross-Sectional Analysis, Abdulellah Modhi Alsolais, Benito Jr Nillo Areola, Amal Alfouzan, Marie Grace Mejia Nones, Talal Ali Alharbi

Makara Journal of Health Research

Background: Reportedly, there has been a long-standing nursing shortage in Saudi Arabia. This study explored the attitudes of undergraduate student nurses considering them to be a factor contributing to this shortage. This study also investigated the association among gender, hospital exposures, and campus enrollment concerning mental health education.

Methods: Quantitative correlational analysis was used on 124 student nurses in mental health nursing. Using Point Binary, Spearman's rank and one-way ANOVA, significant determinants were correlated to the domains of mental health nursing.

Results: Student nurses have a positive attitude toward mental health education. Gender is significantly related to …

Social Media Addiction Among Nursing Students And Its Related Factors, Akgün Yeşiltepe, Bedriye Cansu Demirkiran, Sevgi Demir Çam

Makara Journal of Health Research

Background: Social media use has become an indispensable part of our lives as a result of technology advancement and is quite high among students.

Methods: This study employed a cross-sectional design. Participants were 289 students from the Faculty of Health Sciences at Artvin Coruh University, Turkey. The Social Media Addiction Scale (SMAS) was used to obtain data. T-test, one-way ANOVA, Pearson’s correlation, and Bonferroni analysis were used to analyze the data.

Results: The participants’ mean SMAS score was 81.03 ± 34.79, which was moderate. A weak and positive correlation was found between social media addiction and daily …

Understanding The Experiences Lived By Nurses Caring For Patients With Covid-19: A Hermeneutic Approach, Awatif Mansoor Alrasheeday, Ma. Venus Borja, Eddieson Pasay-An, Farhan Alshammari

Makara Journal of Health Research

Background: Nursing is highlighted among professions that value caring and is perceived as the profession’s heart and soul because of its critical role in providing and delivering high-quality patient care, especially during this coronavirus disease 2019 (COVID-19) pandemic. However, little is understood about the experiences of the frontline workers in caring for persons diagnosed with COVID-19. This study aimed to explore the experiences of nurses in caring for persons diagnosed with COVID-19 inspired by the four lived worlds of van Manen.

Methods: The hermeneutic phenomenology was used in nine nurses working in hospitals of Hail region. This study …

Factors Associated With The Use Of Traditional Health Services In Indonesia: A Secondary Analysis Of The Indonesian Basic Health Research, Niswatul Rifka, Haerawati Idris

Makara Journal of Health Research

Background: Traditional health services in Indonesia have been used increasingly over the past few years because patients nowadays are more proactive in seeking various alternative modes of self-care. This study aimed to analyze factors associated with the use of traditional health services in Indonesia.

Methods: This quantitative study used a cross-sectional research design. The research data were secondary data from the 2018 Indonesian Basic Health Research. The research samples were 163,259 respondents aged >10 years and the statistical test for data analysis was multiple logistic regression.

Results: The percentage of respondents who used traditional health services was …

Determination Of Individuals’ Attitudes Toward Covid-19 Vaccines And Health Fatalism: A Cross-Sectional Study From Turkey, Emre Erkal, Bedriye Cansu Demirkiran, Şerife Köleoğlu, Sevgi Demir Çam

Makara Journal of Health Research

Background: Vaccines have positive effects on the course of epidemics. This study was conducted to determine individuals’ attitudes toward coronavirus disease-2019 (COVID-19) vaccines, their health fatalism, and factors affecting these.

Methods: This cross-sectional study included 944 participants living in Turkey, who were included in the study by snowball sampling, one of the nonprobability random sampling methods. Participant information form, attitudes toward the COVID-19 vaccine scale, and religious health fatalism scale were used to collect the study data. Independent sample t-test, one-way analysis of variance and Pearson correlation analysis were used in the data analysis.

Results: Participants had …

Do Nasal Anatomical Variations Affect The Maxillary Sinus? A Cbct Volumetric Analysis, Raghdaa A. Mostafa, Sahar M. Samir

Journal of Dentistry Indonesia

Objective: This study aimed to determine the effect of the concha bullosa (CB) and the nasal septum deviation (NSD) on the volume of the maxillary sinuses using ITK-SNAP (http://www.itksnap.org/ download/snap/). Methods: A total of 70 CBCT scans were analyzed. Three groups were evaluated; control (absence of CB), unilateral CB, and bilateral CB. Moreover, scans were classified according to the NSD into control (no deviation), mild, moderate, and severe NSD deviation. The volume of each maxillary sinus was calculated using the ITKSNAP. Intra-observer reliability analysis was performed by paired-sample t-test. Analysis of variance ANOVA and t-test were used to …

A Prospective-Randomized Study: The Impact Of Four Different Caries Removal Method On Pain And Clinical Evaluations, Merve Aydemir, Serdar Bağlar

Journal of Dentistry Indonesia

Objective: There are many different methods for removing caries. In this study, to evaluate four caries removal methods in terms of patient comfort and to evaluate the clinical success of restorations according to modified-USPHS criteria. Methods: In 31 patients with at least 4 Class II caries in their posterior teeth, 4 teeth were randomly divided into four groups and 4 different methods (conventional method, Carisolv, Papacarie, Er-Cr:YSGG Laser) were used for caries removal. Pain formation during caries removal was determined by FACE Pain Scale questionnaire. The restorations were controlled with Modified-USPHS criteria in 3-6-12 months period. Mann-Whitney U …

Assessment Of Dna Damage Of Oral Mucosa Due To Ceramic Bracket Using Comet Assay And Mutagenicity Of Orthodontic Bonding System Using Ames Test, Riaz Adham, Norma Ab Rahman, Kannan Thirumulu Ponnuraj

Journal of Dentistry Indonesia

Objective: The objective of this study was to determine the DNA damage caused by ceramic bracket (Clear II, SIA Orthodontic Manufacturer Srl, Italy) on human buccal mucosal cells using comet assay and the mutagenicity of orthodontic bonding system (Transbond XT; 3M Unitek) by Ames test. Methods: In this study, twenty orthodontic patients were recruited from Specialist Orthodontic Clinic, Hospital Universiti Sains Malaysia. The Buccal mucosal cell sample was obtained from each patient at three time points-before (TO), after one month (T1) and after two months (T2) of ceramic bracket placement for performing comet assay. The spot test version …

Students’ Experience, Self-Confidence, And Perception Toward Endodontic Learning: National Survey Among Malaysian Dental Schools, Siti Hajar Omar, Aspalilah Alias, Safura Anita Baharin

Journal of Dentistry Indonesia

Objective: This study aimed to evaluate the first endodontic case experiences, self-confidence levels, and perceptions toward endodontic learning of final-year undergraduate students. Methods: An online questionnaire was emailed to 270 final-year dental students at 10 Malaysian dental schools. The questionnaire consists of 29 questions on students’ experience, self-confidence, and perception toward endodontic learning. Results: The response rate was 74.4%. The most frequently treated case was tooth diagnosed as nonvital associated with periapical periodontitis. Most of the students perceived working length determination as the most difficult stage and reported having low confidence in locating canal orifices in multirooted …

Treatment Of Oral Vascular Malformations With Ethamolin: A Report Of Two Cases, Maria Clara De Moura Santos Coelho Ferreira, Marco Vinícius De Sales Lima, Anna Laura Almeida Barreto, Dárcio Kitakawa, Alexandre Do Prado Scherma, Felipe Peralta, Luis Felipe Das Chagas E Silva De Carvalho

Journal of Dentistry Indonesia

A hemangioma is a benign vascular neoplasm, relatively common in the head and neck. In the oral region, it affects the tongue, gums, mucosa, palate, and lip. Its size can vary from millimeters to centimeters, characterized as a purplish or reddish lesion. The present study aims to present two clinical cases of hemangiomas, the first of a male patient treated by sclerotherapy and the second of a female patient in which she was treated with ethamolin and later surgical treatment. It was concluded that sclerotherapy, in addition to being a safe treatment, managed to drastically reduce the initial size of …

A Two-Year Retrospective Evaluation Of Cone Beam Computed Tomography Indications In Pediatric, Adolescent And Adult Patients, Zeynep Betül Arslan, Esra Ceren Tuğutlu

Journal of Dentistry Indonesia

Objective: The objective was to evaluate cone-beam computed tomography (CBCT) indications and distribution in pediatric, adolescent and adult patients. Methods: A total of 1013 CBCT images were reviewed in detail from the electronic patient database. The patient’s age, gender, CBCT indications and acquisition sites, referral departments, reason for referral, incidental findings in the imaging field and the presence of artifacts in the CBCT images were all recorded. The European DIMITRA project recommendations were used to categorize CBCT indications in the children and the European Guidelines were used for adults. Results: From a total of 1013 images; 5.3% …

Treatment Of Gingival Fenestration Using Mucoperiosteal Flap With Connective Tissue Graft: A Report Of Two Cases, Swati Jaglan, Shikha Tewari

Journal of Dentistry Indonesia

Fenestration term is derived from the Latin word ‘fenestra’ means ‘window’. Gingival fenestration is not found in routine while its actual occurrence is assumed to be higher. Additionally, if these mucogingival defects persist for a longer duration it may lead to adverse outcomes like compromised esthetics, hypersensitivity, plaque and calculus deposition, and susceptibility to dental caries. Present cases of gingival fenestration were successfully treated by using full-thickness flap elevation with connective tissue graft placement. Two cases were presented with the accumulation of plaque and calculus and having gingival fenestration to the respective sites. After phase 1 therapy, full thickness flap …

Management Of Tooth Hypersensitivity Under A Cantilever Fixed Partial Denture Using A Novel Low-Level Laser Therapy Protocol: A Case Report, Mohamed Fattouh, Manal Mohammed Aljuaid, Nada Ali Abdelaleem

Journal of Dentistry Indonesia

Tooth hypersensitivity is a common clinical complaint after dental treatment.

Objective: This study presents a case report of the use of a diode laser for treating tooth hypersensitivity in a patient with a cantilever fixed partial denture abutment.

Case Report: A 23-year-old female patient presented to the Faculty of Dentistry, Umm Al-Qura University in Makkah, with the chief complaint of pain in a deeply carious maxillary right first premolar. The tooth was extracted, and a cantilever fixed partial denture was placed using the second premolar as an abutment. One year later, the patient experienced tooth hypersensitivity under the bridge. Low-level …

Head And Neck Tumor Histopathological Image Representation With Pre- Trained Convolutional Neural Network And Vision Transformer, Ranny Rahaningrum Herdiantoputri, Daisuke Komura, Tohru Ikeda, Shumpei Ishikawa

Journal of Dentistry Indonesia

Image representation via machine learning is an approach to quantitatively represent histopathological images of head and neck tumors for future applications of artificial intelligence-assisted pathological diagnosis systems. Objective: This study compares image representations produced by a pre-trained convolutional neural network (VGG16) to those produced by a vision transformer (ViT-L/14) in terms of the classification performance of head and neck tumors. Methods: W hole-slide images of five oral t umor categories (n = 319 cases) were analyzed. Image patches were created from manually annotated regions at 4096, 2048, and 1024 pixels and rescaled to 256 pixels. Image representations were …

Ramsay Hunt Syndrome With Oral Findings: A Rare Case, İlknur Eninanç, Büşra Şahin

Journal of Dentistry Indonesia

Ramsay Hunt syndrome (RHS) is a disease that is caused by the varicella-zoster virus and is characterized by severe ear pain, auricular vesicular eruptions, and peripheral facial paralysis.

Objective: The aim of this case report is to provide information about the clinical findings and treatment process of RHS, which is a rare case and may have oral findings and stress the importance of early diagnosis.

Case Report: A 60-year-old male patient had previously consulted an otolaryngologist and a family physician with complaints of vesicular eruptions in the right ear auricle and on the mandible. The patient in whom a diagnosis …