Medicine and Health Sciences Commons^™

Ensuring The Continuum Of Interprofessional Education And Collaborative Practice In The Post Graduate Training Years, Joanne Schwartzberg, Dewitt Baldwin Jr., Nicholas Yaghmour

JCIPE Conference

Changing Expectations About Residency Training in Teamwork and Team-based Care

ACGME- 2002 – Six Competencies

• Required Self-Report and Description

ACGME- 2013 – “Milestones”

• Specialty specific, graduated IPECP competencies

“New Accreditation System” 2013-2014

• Mandated Assessment of IPECP competencies 2X/yr.

The Use Of Standardized Patient Simulation For Interprofessional Teaching Of Palliative Care Communication Skills, Ksenia G. Zukowsky, Phd, Nnp-Bc, Kathleen Black, Phd, Rnc, Laura Roettger, Msn, Pnp-Bc, Michael Spear, Md, Msedl

JCIPE Conference

The Use of Standardized Patient Simulation for Interprofessional Teaching of Palliative Care Communication Skills

• Children who receive palliative care services are affected by illnesses that are different in nature and number from those that typically affect adult recipients.

• Interdisciplinary/Interprofessional teams are the norm:

• Special knowledge of pediatric developmental, psychological, social and spiritual dimensions round out the comprehensive palliative care of pediatric patients.

• Even symptom management requires unique assessment tools.

• http://www2.aap.org/sections/palliative/

Developing An Open Educational Resource For Interprofessional Education (Ipe)., Susanne P. Boyle, Matthew Ramirez, Lynn Sheridan

JCIPE Conference

Jisc

Aims

» The development of an online, digitally rich IPE resource which supports an IPE learning experience.

» Employs family narratives, authentic voices and cultural insights to help students visualise and identify with the patient and client scenarios.

» Sharing of the IPE open educational resource (OER) via Jorum.

» Supports HEI sector efficiency and capacity building by the development of a quality IPE Open Educational Resource (OER) which may be adopted, adapted and re-purposed.

Ipe/Ipc: Some Big Issues Theoretical And Methodological, John H.V. Gilbert, C.M., Phd., Fcahs

JCIPE Conference

John H.V. Gilbert, C.M., PhD, FCAHS

Principal & Professor Emeritus

College of Health Disciplines

University of British Columbia

Co-Chair, Canadian Interprofessional Health Collaborative

Adjunct Professor, Dalhousie University

Dr. John Gilbert is founding Principal & Professor Emeritus, College of Health Disciplines, University of British Columbia where he was also founding Director of the School of Audiology and Speech Sciences, and Director of the School of Rehabilitation Sciences.

His many honors include a Fulbright Scholarship; Medical Research Council of Canada Post-Doctoral Scholarship; the Outstanding Alumnus Award of the School of Liberal Arts, Purdue University; a UBC Isaac Killam-Walton Outstanding Teaching Award; The …

“It’S Persuasion Disguised As Information” The Experiences And Adaptations Of Abortion Providers Practicing Under A New Law, Rebecca J. Mercier Md Mph, Mara Buchbinder, Phd, Amy Bryant,Md,Mph, Laura Britton,Rn, Bsn

Department of Obstetrics and Gynecology Presentations and Grand Rounds

Background

Abortion laws are proliferating in the United States. From 2011 to 2013, 30 states passed a total of 205 abortion restrictions.¹ Increasingly, these laws are focused on abortion providers. Such laws have been criticized by professional organizations including the American College of Obstetricians and Gynecologists,² but few studies have assessed the impact of these laws on abortion providers.

In 2011 North Carolina passed HB 854, the “Women’s Right To Know Act” (WRTK). Similar to laws in 26 other states, WRTK mandates a 24-hour waiting period after counseling before an abortion can be performed. Content of the counseling …

Teamstepps: Radiologic Sciences Students’ Perspective, Sandra Freed, Amanda Lafontaine, Daniel Roberts, Allison Urbaniak, Collleen Dempsey, Ms, Rt (R)

Department of Radiologic Sciences Faculty Papers

Introduction

Interprofessional education aims to improve the health care system by encouraging healthcare professionals to learn from, with and about each other.

Interprofessional education activities assist in breaking the barriers between the various disciplines in our healthcare system. Students and employees can benefit from interprofessional education and training.

It's Time We Become A Learning Team, Barbara F. Brandt, Phd

JCIPE Conference

Barbara F. Brandt, PhD

Director, National Center for Interprofessional

Practice and Education

Associate Vice President for Education

University of Minnesota Academic Health Center

Professor, Pharmaceutical Care and Health System

Barbara Brandt is one of the nation’s foremost experts in interprofessional practice and education and a leading force in the creation of the National Center for Interprofessional Practice and Education housed at the University of Minnesota. As center director, Dr. Brandt is responsible for engaging leaders and experts across the country in this ground-breaking effort to improve health by realigning health professions education and care delivery. Dr. Brandt and her colleague, …

Development Of Syringomyelia From Retained Bullet Fragment Following Spinal Cord Injury, Akinpelu Beckley, Md, Mba, Christina V. Oleson, Md, Christopher S. Formal, Md

Department of Rehabilitation Medicine Faculty Papers

Objective

To investigate potential complications of retained bullet fragments in the spinal canal following traumatic spinal cord injury (SCI).

Tp53 Mutations Detected In Circulating Tumor Cells Present In The Blood Of Metastatic Triple Negative Breast Cancer Patients., Sandra V Fernandez, Catherine Bingham, Patricia Fittipaldi, Laura Austin, Juan P. Palazzo, Gary Palmer, Katherine Alpaugh, Massimo Cristofanilli

Department of Medical Oncology Faculty Papers

INTRODUCTION: Circulating tumor cells (CTCs) are tumor cells shed from either primary tumors or its metastases that circulate in the peripheral blood of patients with metastatic cancers. The molecular characterization of the CTCs is critical to identifying the key drivers of cancer metastasis and devising therapeutic approaches. However, the molecular characterization of CTCs is difficult to achieve because their isolation is a major technological challenge.

METHODS: CTCs from two triple negative breast cancer patients were enriched using CellSearch and single cells selected by DEPArray™. A TP53 R110 fs*13 mutation identified by next generation sequencing in the breast and chest skin …

Proton-Sensing Receptors- Therapeutic Targets In The Management Of Asthma?, Raymond B. Penn, Phd

Division of Pulmonary, Allergy, and Critical Care Medicine Presentations and Grand Rounds

Objectives:

• Identify OGR1 as the principal proton-sensing receptor in the airway, capable of regulating airway resistance via its function of airway smooth muscle.
• Identify inflammation, and microaspiration of acid, as two mediators of low pH in the airway lumen.
• List 2 specific drugs that can function as OGR1 activators and potential asthma therapeutics.

Presentation: PowerPoint slides only, no audio

Curcumin-Induced Heme Oxygenase-1 Expression Prevents H2o2-Induced Cell Death In Wild Type And Heme Oxygenase-2 Knockout Adipose-Derived Mesenchymal Stem Cells., Niels A J Cremers, Ditte M S Lundvig, Stephanie C M Van Dalen, Rik F Schelbergen, Peter L E M Van Lent, Walter A Szarek, Raymond F. Regan, Carine E Carels, Frank A D T G Wagener

Department of Emergency Medicine Faculty Papers

Mesenchymal stem cell (MSC) administration is a promising adjuvant therapy to treat tissue injury. However, MSC survival after administration is often hampered by oxidative stress at the site of injury. Heme oxygenase (HO) generates the cytoprotective effector molecules biliverdin/bilirubin, carbon monoxide (CO) and iron/ferritin by breaking down heme. Since HO-activity mediates anti-apoptotic, anti-inflammatory, and anti-oxidative effects, we hypothesized that modulation of the HO-system affects MSC survival. Adipose-derived MSCs (ASCs) from wild type (WT) and HO-2 knockout (KO) mice were isolated and characterized with respect to ASC marker expression. In order to analyze potential modulatory effects of the HO-system on ASC …

Human Library: Thomas Jefferson University Guidelines For Readers, Patricia Wynne, Bsn, Ms

Human Library

No abstract provided.

Human Library: Book Descriptions, Patricia Wynne, Bsn, Ms

Human Library

No abstract provided.

Nurses Alumni Association Bulletin, Fall 2014, Susan Albrecht Curcio, Aileen Ishuin Macmillan

Nursing Alumni Bulletins

2014 - 2015 Meeting Dates Calendar

2015 Annual Luncheon & Meeting Notice

Officers, Committee Chairs, Satellite and Volunteers

President's Message

Treasurer's Report

Resume of Minutes

Alumni Office News

Committee Reports

• Social
• Relief Trust Fund
• Satellite-Harrisburg Satellite Area
• Scholarship
• Nominating
• Bulletin
• By Laws

Jefferson Alumni Relations

Annual Giving

Janet C. Hindson Award

• Award Criteria
• Nominees
• Recipient

News About Our Graduates

Memories

Happy Birthday - To Be 80 or More

50th Anniversary Class List for 1964

Luncheon Reservations

Annual Luncheon Comments

• Luncheon Photos
• Anniversary Class List for 2015 Annual Luncheon

In Memoriam, Names of Deceased Graduates

Class News

Additional Information, Pins, Transcripts …

Jefferson Digital Commons Quarterly Report: July-September 2014, Daniel G. Kipnis, Msi, Kelsey Duinkerken, Msi

Jefferson Digital Commons Reports

This Jefferson Digital Commons quarterly report will cover the following:

• Milestone: 2 million downloads for the Jefferson Digital Commons
• Some statistics
• New assets added to the JDC
• Historical Materials
• What people are saying about the JDC

Rationale And Design Of The Guide-It Study: Guiding Evidence Based Therapy Using Biomarker Intensified Treatment In Heart Failure., G. Michael Felker, Tariq Ahmad, Kevin J. Anstrom, Kirkwood F. Adams, Lawton S. Cooper, Justin A. Ezekowitz, Mona Fiuzat, Nancy Houston-Miller, James L. Januzzi, Eric S. Leifer, Daniel B. Mark, Patrice Desvigne-Nickens, Gayle Paynter, Ileana L. Piña, David J. Whellan, Christopher M. O'Connor

Division of Cardiology Faculty Papers

OBJECTIVES: The GUIDE-IT (Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure) study is designed to determine the safety, efficacy, and cost-effectiveness of a strategy of adjusting therapy with the goal of achieving and maintaining a target N-terminal pro-B-type natriuretic peptide (NT-proBNP) level of

BACKGROUND: Elevations in natriuretic peptide (NP) levels provide key prognostic information in patients with HF. Therapies proven to improve outcomes in patients with HF are generally associated with decreasing levels of NPs, and observational data show that decreases in NP levels over time are associated with favorable outcomes. Results from smaller prospective, randomized studies …

Treatment Of Duodenal Variceal Hemorrhage With Endoscopic Band Ligation, Tripti R. Chopade, Md, Jesse M. Civan, Md, Jonathan M. Fenkel, Md, Ali A. Siddiqui, Md, Ashish R. Gandhe, Md, Dina L. Halegoua-De Marzio, Md

Division of Gastroenterology and Hepatology Faculty Papers

Introduction

• Duodenal varices (DV) are a rare but potentially serious complication of portal hypertension and carry a high risk of massive gastrointestinal bleeding.

• This is a report of successful treatment of a massive DV hemorrhage with endoscopic band ligation.

Listing Practices For Morbidly Obese Patients At Liver Transplant Centers In The United States, Dina Halegoua-De Marzio, Md, She-Yan Wong, Md, Jonathan M. Fenkel, Md, Cataldo Doria, Md, Phd, David A. Sass, Md

Division of Gastroenterology and Hepatology Faculty Papers

Introduction

• Obesity affects more than one third of Americans.
• Morbid obesity (body mass index (BMI) >35 kg/m2) has been associated with multiple co-morbidities and perioperative complications.
• The effect of morbid obesity on liver transplant outcomes has yielded mixed results.

Enteral Nutrition Support For A Sarcopenia In End-Stage Liver Disease, Dina Halegoua-De Marzio, Md, She-Yan Wong, Md, Flavius Guglielmo, Md, Jonathan M. Fenkel, Md

Division of Gastroenterology and Hepatology Faculty Papers

Introduction

• Weight loss with muscle wasting, also known as sarcopenia, commonly occurs in patients with end-stage liver disease (ESLD).
• A robust association between sarcopenia and mortality in cirrhotic and post-liver transplant patients has been reported.
• This is a report of a patient with severe sarcopenia and ESLD who was provided enteral nutrition using a Dobhoff tube (DHT) pre-liver transplant resulting in successful bridging to transplant.

Evaluating Initial Spine Trauma Response: Injury Time To Trauma Center In Pa, Usa., James Harrop, Md, George M. Ghobrial, Md, Rohan Chitale, Md, Kelly Krespan, Laura Odorizzi, Tristan Fried, Mitchell Maltenfort, Phd, Murray Cohen, Md, Alex R. Vaccaro, Md

Department of Neurosurgery Faculty Papers

Historical perceptions regarding the severity of traumatic spinal cord injury has led to considerable disparity in triage to tertiary care centers. This article retrospectively reviews a large regional trauma database to analyze whether the diagnosis of spinal trauma affected patient transfer timing and patterns. The Pennsylvania Trauma database was retrospectively reviewed. All acute trauma patient entries for level I and II centers were categorized for diagnosis, mechanism, and location of injury, analyzing transportation modality and its influence on time of arrival. A total of 1162 trauma patients were identified (1014 blunt injuries, 135 penetrating injuries and 12 other) with a …

Subgroups Of Cancer Patients With Unique Pain And Fatigue Experiences During Chemotherapy, Heeju Kim, Patrick S. Malone, Andrea M. Barsevick

Department of Medical Oncology Faculty Papers

Context. Some cancer patients experience pain and fatigue, whereas others experience only one of the two symptoms. Yet, it is not clear who experiences these unique patterns and why.

Objectives. This study aimed to identify subgroups of cancer patients with unique pain and fatigue experiences in two different chemotherapy cycles to examine how selected factors influenced subgroup membership and identify how subgroups differed in concurrently measured functional limitation outcome.

Methods. The sample included 276 patients with diverse cancer types from four U.S. sites. To investigate subgroups, latent profile analyses were performed. Multinomial logistic regression and one-way analysis of variance-type analyses …

Isomir Expression Profiles In Human Lymphoblastoid Cell Lines Exhibit Population And Gender Dependencies., Phillipe Loher, Eric R Londin, Isidore Rigoutsos

Computational Medicine Center Faculty Papers

For many years it was believed that each mature microRNA (miRNA) existed as a single entity with fixed endpoints and a 'static' and unchangeable primary sequence. However, recent evidence suggests that mature miRNAs are more 'dynamic' and that each miRNA precursor arm gives rise to multiple isoforms, the isomiRs. Here we report on our identification of numerous and abundant isomiRs in the lymphoblastoid cell lines (LCLs) of 452 men and women from five different population groups. Unexpectedly, we find that these isomiRs exhibit an expression profile that is population-dependent and gender-dependent. This is important as it indicates that the LCLs …

Persistent At-Level Thermal Hyperalgesia And Tactile Allodynia Accompany Chronic Neuronal And Astrocyte Activation In Superficial Dorsal Horn Following Mouse Cervical Contusion Spinal Cord Injury., Jaime L Watson, Tamara J Hala, Rajarshi Putatunda, Daniel Sannie, Angelo C Lepore

Department of Neuroscience Faculty Papers

In humans, sensory abnormalities, including neuropathic pain, often result from traumatic spinal cord injury (SCI). SCI can induce cellular changes in the CNS, termed central sensitization, that alter excitability of spinal cord neurons, including those in the dorsal horn involved in pain transmission. Persistently elevated levels of neuronal activity, glial activation, and glutamatergic transmission are thought to contribute to the hyperexcitability of these dorsal horn neurons, which can lead to maladaptive circuitry, aberrant pain processing and, ultimately, chronic neuropathic pain. Here we present a mouse model of SCI-induced neuropathic pain that exhibits a persistent pain phenotype accompanied by chronic neuronal …

Plasma Adiponectin, Clinical Factors, And Patient Outcomes During The Acute Respiratory Distress Syndrome., Allan J Walkey, Serkalem Demissie, Dilip Shah, Freddy Romero, Leah Puklin, Ross S Summer

Center for Translational Medicine Faculty Papers

OBJECTIVE: Adiponectin (APN) is an anti-inflammatory hormone derived from adipose tissue that attenuates acute lung injury in rodents. In this study, we investigated the association between circulating APN and outcomes among patients with acute respiratory distress syndrome (ARDS).

METHODS: We performed a retrospective cohort study using data and plasma samples from participants in the multicenter ARDS Network Fluid and Catheter Treatment Trial.

RESULTS: Plasma APN concentrations were measured in 816 (81.6%) trial participants at baseline and in 568 (56.8%) subjects at both baseline and day 7 after enrollment. Clinical factors associated with baseline APN levels in multivariable-adjusted models included sex, …

Inferior Meatus Maxillary Antrostomy: Time To Revisit A Previously Abandoned Surgical Technique?, Natalie Ziegler, Bs, Alfred Marc C. Lloreta, Md, Alexander Farag, Md, Ting Ting Zhan, Phd, Gurston G. Nyquist, Md, Marc Rosen, Md

Department of Otolaryngology - Head and Neck Surgery Presentations and Grand Rounds

Background: A small subset of patients have dysfunctional maxillary sinus mucosa. These patients require more aggressive surgical treatment to allow for gravity dependent mucous drainage, intra-operative and office debridements, and the delivery of irrigations and topical treatments. The aim of this study is to examine the use of inferior meatus maxillary antrostomy (IMMA) in combination with traditional maxillary antrostomy, in this challenging patient population.

Methods: We performed a retrospective study from February, 2008 until April, 2014 with a 118 patients undergoing a total of 128 IMMA procedures. Data was gathered regarding patient demographic, prior therapy, post-operative medical therapy, IMMA patency, …

Association Of Leukocyte Mitochondrial Dna Content With Glioma Risk: Evidence From A Chinese Case-Control Study., Jie Zhang, Deyang Li, Falin Qu, Yibing Chen, Gang Li, Hequn Jiang, Xiaojun Huang, Hushan Yang, Jinliang Xing

Department of Cancer Biology Faculty Papers

BACKGROUND: Increasing evidence suggests that alterations in mitochondrial DNA (mtDNA) content may be implicated in the tumorigenesis of several malignancies. However, the association between mtDNA content in peripheral blood lymphocytes (PBLs) and glioma risk has not been investigated.

METHODS: Real-time PCR was used to examine the mtDNA content in PBLs of 414 glioma patients and 414 matched controls in a hospital-based case-control study. The association between mtDNA content and glioma risk was evaluated using an unconditional multivariate logistic regression model.

RESULTS: We found that glioma patients exhibited a significantly higher median mtDNA content than healthy controls (0.99 vs. 0.71, P …

Information Session: Aamc’S Teaching For Quality (Te4q) At Jefferson, David B. Nash, Md, Mba, Alexis Skoufalos, Edd

College of Population Health Lectures, Presentations, Workshops

This information session facilitated by David Nash, MD, MBA, and Alexis Skoufalos, EdD, introduces participants and viewers to the AAMC’s “Teaching for Quality (Te4Q)” program, hosted by Jefferson’s Patient Safety Leadership Institute. Te4Q is a faculty development program designed to help clinical faculty effectively teach and implement quality improvement and patient safety education initiatives. This session provides an overview of the program including the initial 1 ½ day workshop, which will be held on the Jefferson campus on Thursday and Friday, November 20 and 21, 2014. This enterprise-wide endeavor is being jointly sponsored by TJU/TJUH, thanks to …

Risk Factors For Surgical Site Infection Following Total Joint Arthroplasty., Mohammad R Rasouli, Camilo Restrepo, Mitchell Maltenfort, Phd, James J Purtill, Javad Parvizi

Rothman Institute Papers

BACKGROUND: Currently, most hospitals in the United States are obliged to report infections that occur following total joint arthroplasty to the Centers for Disease Control and Prevention through the National Healthcare Safety Network surveillance. The objective of this study was to identify the risk factors of surgical site infections that were reported to the Centers for Disease Control and Prevention from a single institution.

METHODS: For this study, 6111 primary and revision total joint arthroplasties performed from April 2010 to June 2012 were identified. Surgical site infection cases captured by infection surveillance staff on the basis of the Centers for …

Emerging Multidrug Resistance Of Methicillin-Resistant Staphylococcus Aureus In Hand Infections., Rick Tosti, Brian T Samuelsen, Samantha Bender, John R Fowler, John Gaughan, Alyssa A Schaffer, Asif M Ilyas

Rothman Institute Papers

BACKGROUND: Methicillin-resistant Staphylococcus aureus has been the most commonly identified pathogen in hand infections at urban centers, but the evolving antibiotic sensitivity profiles of methicillin-resistant Staphylococcus aureus are not known. The purposes of this study are to determine if multidrug resistance in methicillin-resistant Staphylococcus aureus is emerging and to provide current recommendations for empiric antibiotic selection for hand infections in endemic regions.

METHODS: An eight-year longitudinal, retrospective chart review was performed on all culture-positive hand infections encountered by an urban hospital from 2005 to 2012. The proportions of all major organisms were calculated for each year. Methicillin-resistant Staphylococcus aureus infections …

Two Million Downloads For The Jefferson Digital Commons, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

Strike up the band, turn up the tunes, and break out your dancing shoes! On September 14, 2014 the Jefferson Digital Commons surpassed 2 million downloads. As of Monday September 15, 2014 the JDC has 2,000,842 total downloads.