Medicine and Health Sciences Commons^™

Loss Of Hif-1Α In The Notochord Results In Cell Death And Complete Disappearance Of The Nucleus Pulposus., Christophe Merceron, Laura Mangiavini, Alexander Robling, Tremika Leshan Wilson, Amato J Giaccia, Irving Shapiro, Ernestina Schipani, Makarand V Risbud

Department of Orthopaedic Surgery Faculty Papers

The intervertebral disc (IVD) is one of the largest avascular organs in vertebrates. The nucleus pulposus (NP), a highly hydrated and proteoglycan-enriched tissue, forms the inner portion of the IVD. The NP is surrounded by a multi-lamellar fibrocartilaginous structure, the annulus fibrosus (AF). This structure is covered superior and inferior side by cartilaginous endplates (CEP). The NP is a unique tissue within the IVD as it results from the differentiation of notochordal cells, whereas, AF and CEP derive from the sclerotome. The hypoxia inducible factor-1α (HIF-1α) is expressed in NP cells but its function in NP development and homeostasis is …

Predictors Of Infections Following Cranioplasty: A Retrospective Review Of A Large Single Center Study., Mario Zanaty, Nohra Chalouhi, Md, Robert M Starke, Rohan Chitale, Md, Shannon Hann, Md, Cory D Bovenzi, Mark P Saigh, Eric W Schwartz, Emily S I Kunkel, Alexandra S Efthimiadis-Budike, Pascal Jabbour Md, Richard Dalyai, Robert H. Rosenwasswer Md, Stavropoula Tjoumakaris

Department of Neurosurgery Faculty Papers

Introduction. The variables that predispose to postcranioplasty infections are poorly described in the literature. We formulated a multivariate model that predicts the risk of infection in patients undergoing cranioplasty. Method. Retrospective review of all patients who underwent cranioplasty following craniectomy from January, 2000, to December, 2011. Tested predictors were age, sex, diabetic status, hypertensive status, reason for craniectomy, urgency status of craniectomy, location of cranioplasty, reoperation for hematoma, hydrocephalus postcranioplasty, and material type. A multivariate logistic regression analysis was performed. Results. Three hundred forty-eight patients met the study criteria. Infection rate was 26.43% (92/348). Of these cases with infection, 56.52% …

Clinical Vignette: A Case Of Successful Surgical Decortication For Empyema With Trapped Lung, In A Patient With Decompensated Cirrhosis, Tripti R. Chopade, Md, She-Yan Wong, Md, David A. Sass, Md, Scott W. Cowan, Md, Jesse M. Civan, Md

Division of Gastroenterology and Hepatology Faculty Papers

Introduction

Hepatic hydrothorax (HH) is a difficult-to-control complication of cirrhosis. Chest tube (CT) drainage is an option for management of HH, but is associated with a high rate of secondary infection and other complications.

Regular Dipyridamole Therapy Produces Sustained Protection Against Cardiac Ischemia-Reperfusion Injury: Is It Time To Revisit Paris?, Vincent M. Figueredo, M.D., Chika Okusa, Kazuhiro Kaneda, Yoshitaka Inamura, Masami Miyamae

Division of Cardiology Faculty Papers

BACKGROUND: Increased activated Akt and eNOS expression coincide with this persistent cardioprotection. Emergent coronary reperfusion therapies are rarely carried out before considerable myocardial injury has occurred. Moreover, reperfusion after prolonged ischemia produces paradoxical ischemia-reperfusion injury, attenuating the efficacy of reperfusion therapies. This has provided impetus for identifying chronic therapies to protect against ischemia-reperfusion injury in those at risk. We previously found that regular dipyridamole therapy produces a chronic preconditioning-like effect mediated through adenosine A1 receptors.

METHODS: To determine how long this chronic preconditioning effect of dipyridamole remains present after discontinuing therapy, guinea pigs received 4 mg/kg/day in their water for …

Experimental Study Of Needle-Tissue Interaction Forces: Effect Of Needle Geometries, Insertion Methods And Tissue Characteristics., Shan Jiang, Pan Li, Yan Yu, Jun Liu, Zhiyong Yang

Department of Radiation Oncology Faculty Papers

A thorough understanding of needle-tissue interaction mechanics is necessary to optimize needle design, achieve robotically needle steering, and establish surgical simulation system. It is obvious that the interaction is influenced by numerous variable parameters, which are divided into three categories: needle geometries, insertion methods, and tissue characteristics. A series of experiments are performed to explore the effect of influence factors (material samples n=5 for each factor) on the insertion force. Data were collected from different biological tissues and a special tissue-equivalent phantom with similar mechanical properties, using a 1-DOF mechanical testing system instrumented with a 6-DOF force/torque (F/T) sensor. The …

Gucy2c Lysosomotropic Endocytosis Delivers Immunotoxin Therapy To Metastatic Colorectal Cancer., Glen P Marszalowicz, Adam E. Snook, Michael Sullivan Magee, Dante Merlino, Lisa D Berman-Booty, Scott A Waldman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

The emergence of targeted cancer therapy has been limited by the paucity of determinants which are tumor-specific and generally associated with disease, and have cell dynamics which effectively deploy cytotoxic payloads. Guanylyl cyclase C (GUCY2C) may be ideal for targeting because it is normally expressed only in insulated barrier compartments, including intestine and brain, but over-expressed by systemic metastatic colorectal tumors. Here, we reveal that GUCY2C rapidly internalizes from the cell surface to lysosomes in intestinal and colorectal cancer cells. Endocytosis is independent of ligand binding and receptor activation, and is mediated by clathrin. This mechanism suggests a design for …

Cerebral Arteriovenous Malformations: Evaluation And Management., Norman Ajiboye, Nohra Chalouhi, Md, Robert M Starke, Mario Zanaty, Rodney Bell, Md

Department of Neurosurgery Faculty Papers

There has been increased detection of incidental AVMs as result of the frequent use of advanced imaging techniques. The natural history of AVM is poorly understood and its management is controversial. This review provides an overview of the epidemiology, pathophysiology, natural history, clinical presentation, diagnosis, and management of AVMs. The authors discussed the imaging techniques available for detecting AVMs with regard to the advantages and disadvantages of each imaging modality. Furthermore, this review paper discusses the factors that must be considered for the most appropriate management strategy (based on the current evidence in the literature) and the risks and benefits …

A 360 Degree View Of The Jefferson Health Mentors Program: Students, Administrator And Faculty Weigh In On Seven Years Of Interprofessional Education, Lauren Collins, Md, Tracey Vause-Earland, Ms, Otr/L, Sarah Dallas, Ba, Sokha Koeuth, Bba, Mph, Gealina Dun, Joseph Altmann, Amanda Gibson, Chelsea Gorman, Valerie Weaver

JCIPE Conference

Learning Objectives

•List three strategies for successful implementation of an Interprofessional Education (IPE) curriculum

•Develop a roadmap for starting, expanding or evaluating an existing IPE program

•Discuss challenges and shared lessons learned with CQI in implementing IPE with a panel hosted by HMP students, administrator and faculty

Creating An Ongoing Sustainable Culture Of Interprofessional Education And Practice, Cecilia Rokusek, Ed.D., M.Sc., Rdn, Kamilah Thomas-Purcell, Ph.D., Ches, Stacey Pinnock, M.S.W.

JCIPE Conference

Objectives:

Discuss the attitude, knowledge, and skill challenges to address for students, faculty and community clinician in implementing both interprofessional education and practice

Discuss the ongoing work of the university Interprofessional Education Collaborative

Discuss ongoing efforts in evaluation and culture assessment

An Interprofessional Education Workshop Integrating Pharmacy, Physical Therapy, Occupational Therapy, And Physician Assistant Students And Faculty, Kimberly D. Ward, Pt, Dpt, Pcs, Mph, Joan Ward, Ms, Pa-C, Diane E. Hadley, Pharmd, Bcacp, Sanchita Sen, Pharmd, Bcps, Radha Patel Pharmd, Bcacp, Jennifer Pitonyak, Phd, Otr/L, Scfes

JCIPE Conference

Jefferson Seminar Purpose

•This seminar will describe a case-based interprofessional education (IPE) workshop used to facilitate interprofessional learning

–Planning

–Implementation

–Assessment

Interprofessional Education Initiatives At Salus University: A Unique Perspective In Both Didactic And Clinical Education, Anthony Distefano, Od, Mph, Med, Radhika Aravamudhan, Phd, Linda Casser, Od, Faao, Missy Vitek, Od

JCIPE Conference

Introduction and Sequence

• Dr. Aravamudhan: Introduction to the Session and Presenters.
• Dr. Di Stefano: Introduction to Salus and IPE.
• Dr. Casser: IPE task force and Jeff connection
• Dr. Vitek : Evidence based practice –Evolution and Implementation –Lessons learned.
• Dr. Aravamudhan: Specifics on the CPS Initiative and wrap up.

Changing Student Attitudes Toward Interprofessional Learning And Collaboration: Partnering With Healthcare Mentors In The Academic Setting, Mary Baumberger-Henry, Phd, Rn, Normajean Colby, Phd, Rn, Cne, Patricia Fletcher, Msw, Lcsw, Linda Knauss, Phd, Abpp, Bob Wellmon, Pt, Dpt, Phd, Ncs

JCIPE Conference

Healthcare Mentor Project

• Individuals with one or more chronic health conditions
• Share their time with students
• Help students understand how to provide effective care
• Participation helps to make learning more authentic

Dual Task Training For The Geriatric Client: Promoting Attention To Detail, Genevieve Pinto Zipp, Pt, Edd, Catherine Maher, Pt, Dpt

JCIPE Conference

Objectives:

• To describe the impact of dual tasking on the functional mobility of older adults
• To explore the role of interprofessional educational series to impact older adults attention to detail
• To discuss the utilization of technology and social media in dissemination of an interprofessional educational series for older adults

An Instrument For Measuring Attitudes Toward Interprofessional Collaboration: A Pilot Study, Julia Ward, Phd, Rn, Mohammadreza Hojat, Phd

JCIPE Conference

Learner Objectives

•The learner will describe the rationale for the development of a scale that measures attitudes towards interprofessional collaboration

•The learner will identify the step-by-step procedure for instrument development

Let’S Create A Culture Of Emotional Intelligence, Mary Hanson-Zalot, Msn, Rn, Aocn, Collleen Dempsey, Ms, Rt(2), Julia Ward, Phd

JCIPE Conference

At the conclusion of this session participants will be able to:

• Identify challenges of navigating institutional culture for students interacting in a variety of clinical settings.

•Discuss the importance of integrating concepts of emotional intelligence throughout curricular plans of study.

•Consider contemporary research findings in the health science literature regarding emotional intelligence among students.

Establishing Student Directed Occupational Therapy Services At Iu Student Outreach Clinic: Learning In The Changing Health Care Market, Sharon Pape, Ms, Otr, Lindsey Yoh, Ots, Sarah Koning, Ots

JCIPE Conference

Presentation Objectives

• Recognize the interdisciplinary educational benefits for health professional students at IUSOC
• Describe the unique contributions of occupational therapy within this primary care setting
• Discuss future IPE collaborative opportunities

Teamwork Observation Guide (Jtog): A Teaching Tool For Ipe, Kellie Smith, Bsn, Msn, Edd, David George, Md, Carolyn Giordano, Phd, Kevin J. Lyons, Phd, Elizabeth T. Speakman, Edd, Rn, Anef

JCIPE Conference

Objectives

• Discuss the Jefferson Teamwork Observation Guide (JTOG)

• As a method to measure IPE competencies in an educational, simulation or practice setting

• As a way to help students’ understand the components of team approaches to patient care

Interprofessional Patient/Family Education During Student Clinical Rotations, Bhavik Shah, Pharmd, Susan Egger, Msn, Rn, Ellena A. Anagnostis, Pharmd, Bcps, Mary Hanson-Zalot, Msn, Rn, Aocn, Susan Grady, Msn, Rn, Apn

JCIPE Conference

Learning Objective

1.Describe the rationale for providing patient/family education on medication self-management through nursing and pharmacy student collaboration.

2.Explain the benefits of teaching students a standardized, interprofessional patient/family education instructional strategy for use in the clinical setting during the delivery of patient-centered care.

Evaluation Of An Interprofessional Geriatric Clinical Skills Fair, Brooke Salzman, Md, Lauren Collins, Md, Emily Hajjar, Pharmd, Leigh Ann Hewston, Pt, Cecelia Borden, Edd, Msn, Tracey Vause-Earland, Ms, Otr/L, Carolyn Giordano, Phd, Sarah Ballas, Ba

JCIPE Conference

Objectives

•Describe the utilization of an interprofessional geriatric clinical skills fair to impart knowledge and skills pertaining to both core geriatric and IPE competencies.

•Prepare to introduce an Interprofessional Geriatric Clinical Skills Fair at one’s own institution

•Recognize essential elements of a measurement tool that evaluates the effectiveness of an Interprofessional Geriatric Clinical Skills Fair

Inter-Professional Service Learning To Increase Students' Understanding Of Migrant Latino Health, Jean Davison, Dnp, Rn, Fnp, Ronald Herring, Dawn Macelroy, Christine Walko, Elizabeth Prata, Monica Schmucker, Kent Kessinger, Emiko Davison, Gwen Sherwood, Jorge Aguilera, Md, Pastor Moises Chino Murillo

JCIPE Conference

Learning Objectives

At the end of this seminar participants will be able to:

1.Explain the relevance of inter-professional, cultural competent, global health approaches to health assessment and interventions at home and abroad.

2.Identify evidence-based programs to improve target population health, utilizing the CLAS standards to advance health equity, improve quality and help eliminate health disparities.

3.Design a service learning inter-professional health education course with teaching strategies for cultural competency training that utilizes academic and clinical partnerships.

Patient-Aligned Care Teams, Richard C. Stark, Md

JCIPE Conference

Richard C. Stark, MD

Executive Director,

Primary Care Operations

VA Central Office

Richard C. Stark, MD is the Executive Director of Primary Care Operations for the Veterans Health Administration, Washington, DC. He oversees and supports the field in delivering quality-oriented, efficient, timely, safe and effective Primary Care to over 5.3 million Veterans across the country in almost 1000 sites of care. In this role, Dr. Stark has played an integral part in developing, leading and providing guidance to VA facilities on implementation of Patient-Aligned Care Teams (PACT), VA’s medical home model. In his 32 year career with VA, Dr. Stark …

Special Panel Presentation: Aligning Interprofessional Education With Clinical Practice Redesign: Interprofessional Care For The 21st Century: Redefining Education And Practice, Malcolm Cox, Md

JCIPE Conference

Malcolm Cox, MD

Chief Academic Affiliations Officer (Retired)

Veterans Health Administration

Adjunct Professor, Perelman School of Medicine

University of Pennsylvania

Dr. Cox is an Adjunct Professor at the Perelman School of Medicine, University of Pennsylvania. He most recently served for eight years as the Chief Academic Affiliations Officer for the U.S. Department of Veterans Affairs, in Washington DC, where he oversaw the largest health professions training program in the country and repositioned the VA as a major voice in clinical workforce reform, educational innovation, and organizational transformation. Dr. Cox received his undergraduate education at the University of the Witwatersrand and …

Va Centers Of Excellence In Primary Care Education, Kathryn Rugen, Phd, Fnp-Bc, Stuart Gilman, Md, Mph

JCIPE Conference

VETERANS HEALTH ADMINISTRATION

CoEPCE Purpose

•Develop and test innovative approaches for curricula related to core competencies of patient-centered care.

•Study the impact of new educational approaches and models on health professions education to include collaboration, cultural shifts in educational priorities, and educational and workforce outcomes within and beyond VA.

•Improve primary care instructional strategies with emphasis on workplace learning

Stuart C. Gilman, MD, MPH

Director, Advanced Fellowships and Professional Development

Centers of Excellence in Primary Care Education

Office of Academic Affiliations

Veterans Health Administration

In his role as Director, Advanced Fellowships and Professional Development, Office of Academic Affiliations, Veterans Health …

Does A Contraceptive Bridge Method Affect Rates Of Postpartum Iud Placement In A Resident Urban Clinic?, Agatha Berger, Md, Erica Hinz, Md, Katherine Lackritz, Md, Elisabeth Woodhams, Md, Msc

Department of Obstetrics and Gynecology Presentations and Grand Rounds

Background

• Short interval pregnancies are associated with poor neonatal outcomes.1
• The postpartum (PP) period is an ideal time for LARC prevention of short interval pregnancy.2
• 29% of patients at our clinic admitted not using contraception 4-6 months postpartum.3

The Career Support Network: An Interdisciplinary Model Integrating Chronic Disease Prevention And Management Programs, Public Health And Occupational Therapy Into A Workforce Development Program For Low Skilled, Low Resourced Individuals, Rickie Brawer, Mph, Phd, Mches, James D. Plumb, Md, Mph, Stephen Kern, Phd, Otr/L, Faota, Robert Walsh, Ms, Otr/L

JCIPE Conference

THE CAREER SUPPORT NETWORK (CSN)

Historical Perspective: What led us to the CSN?

Transformational Leadership: Creating A Culture Of Cross-Institutional Ipe Collaboration, David Farmer, Phd, Lpc, Lmft, Susan Mace Weeks, Dnp, Rn, Cns, Lmft, Faan, Lawrence Cohen, Pharmd, Bcpp, Fashp, Fccp, Fcp

JCIPE Conference

Facilitating Structures

• Engagement of senior leaders

• Mutual appointment to IPE leadership groups

• Memorandum of understanding

• Joint appointments

• Communication and time

• Collaboration as a value

• Commitment to Trial and Refinement

• A Foundation of Trust

Leading From The Center Or Leading From The Side? Distinctions In Collaborative Leadership, William Gordon, Dmin, Mdiv

JCIPE Conference

Objectives

•Assess qualities of leadership in terms of how they facilitate collaborative leadership

•Apply a framework of collaborative leadership to educational initiatives and experiences

Creating An Interprofessional Faculty And Student Global Health Grant Program, Virginia Rowthorn, Jd, Rosemary F. Riel, Maa, Jody Olsen, Phd, Msw

JCIPE Conference

UMB Center for Global Education Initiatives

• Founded in 2004 with an NIH Fogarty International Center “Framework” Grant that provided funds to universities to encourage capacity building & training in global health across schools on an academic campus.
• Focus: interprofessional global health education

The Collaborative Continuous Coordinated Care (3cs) Model Hartford Institute For Geriatric Nursing, Maryanne Giuliante, Dnp, Rn, Gnp, Anp-C

JCIPE Conference

Goals of Project

• Build an education-practice model which increases pharmacologic adherence among older, homebound adults

• Develop an innovative interprofessional model which increases the formation of meaningful, Interdisciplinary collaborative relationships

• Create an opportunity for professionals to work together

Using Technology To Enhance Interprofessional Education To Promote Collaborative Practice For Students, Kathryn Shaffer, Rn, Edd, Elizabeth T. Speakman, Edd, Rn, Anef, Fnap, Christine K Wade, Edd, Pt, Rn

JCIPE Conference

To Err Is Human: Building a Safer Health System Recommended interdisciplinary team training to increase patient safety and quality health care IOM, 1999

Crossing the Quality Chasm All health professionals should be educated to deliver patient-centered care as members of an interdisciplinary team, emphasizing evidence-based practice, quality improvement approaches, and informatics, IOM, 2001

Health Professions Education: A Bridge to Quality Once in practice, health professionals are asked to work in interdisciplinary teams, often to support those with chronic conditions, yet they are not educated together or trained in team-based skills, IOM, 2003

The Future of Nursing: Leading Change, Advancing Health …