Medicine and Health Sciences Commons^™

Careers In Quality Panel, Joseph M. Montella, Md, Ms, Cpe (Moderator And Panel Speaker), Lawrence D. Ward, Md, Mph, Facp, Robert M. Dressler, Md, Mba, Marina V. Zeltser, Md, Mba

Future Leaders in Quality and Safety

No abstract provided.

Engaging In Quality Panel, David B. Nash, Md, Mba (Moderator), Rebecca C. Jaffe, Md, Bracken Babula, Md, Martin Wegman, Maria Montano

Future Leaders in Quality and Safety

No abstract provided.

Case Discussions: We Made The New York Times, James F. Pelegano, Md, Ms

Future Leaders in Quality and Safety

No abstract provided.

Case Discussions: Post Event Debrief An Integral Part Of Our Patient Safety Culture, Kathleen Mcnicholas, Md, Facs, Jd, Llm, Cmq

Future Leaders in Quality and Safety

No abstract provided.

Lunch And Small Group Discussions, Bracken P. Babula, Md, Samara Ginzburg, Md, Brian Glynn, Bs, Rrt, Rabecca C. Jaffe, Md, Jennifer Myers, Md, Fhm, Facp, Elisabeth J.S. Kunkel, Md, Monika Pogorzelska-Maziarz, Phd, Mph, Mark Lyles, Md, Mba, Facmq, Martin Wegman

Future Leaders in Quality and Safety

No abstract provided.

The Team Approach: A Conversation With Acmq Vice President, Mark Lyles, Md, Mba, Facmq

Future Leaders in Quality and Safety

No abstract provided.

Quality And Safety In The Urban Environment, Susan L. Freeman, Md, Ms, Facpe, Face

Future Leaders in Quality and Safety

No abstract provided.

Undergraduate And Graduate Curriculum In Quality, Jennifer Myers, Md, Fhm, Facp

Future Leaders in Quality and Safety

No abstract provided.

Undergraduate And Graduate Curriculum In Quality: Healthcare Improvement Sciences In Ume, Samara Ginzburg, Md

Future Leaders in Quality and Safety

No abstract provided.

Keynote Presentation: Future Leaders In Quality And Safety, Peter Angood, Md, Frcs(C), Facs, Mccm

Future Leaders in Quality and Safety

No abstract provided.

Welcome And Opening Remarks, David B. Nash, Md, Mba, Diana Huang

Future Leaders in Quality and Safety

No abstract provided.

Primary Care In Geriatrics: Context, Opportunities, And Resources For Occupational Therapy, Catherine V. Piersol, Phd, Otr/L

Department of Occupational Therapy Posters and Presentations

Learning Objectives:

1. Discuss health care delivery trends and system changes that offer opportunities for occupational therapy in primary care for older adults in the community.

2. Describe the contributions of occupational therapy on the interprofessional primary care team.

3. Utilize current resources and evidence that support the role of occupational therapy in geriatric primary care.

Agenda:

1. Overview of primary care.

2. Health trends and reform initiatives that open doors for occupational therapy.

3. Opportunities (and barriers) for occupational therapy in primary care

4. Current NIH funded study testing a primary care occupational therapy intervention.

5. Resources and Discussion. …

Kallikrein Family Proteases Klk6 And Klk7 Are Potential Early Detection And Diagnostic Biomarkers For Serous And Papillary Serous Ovarian Cancer Subtypes., Ayala Tamir, Ushma Jag, Sreeja Sarojini, Craig Schindewolf, Takemi Tanaka, Rajendra Gharbaran, Hiren Patel, Anil Sood, Wei Hu, Ruzeen Patwa, Patrick Blake, Polina Chirina, Jin Oh Jeong, Heejin Lim, Andre Goy, Andrew Pecora, K Stephen Suh

Department of Medicine Faculty Papers

BACKGROUND: Early detection of ovarian cancer remains a challenge due to widespread metastases and a lack of biomarkers for early-stage disease. This study was conducted to identify relevant biomarkers for both laparoscopic and serum diagnostics in ovarian cancer.

METHODS: Bioinformatics analysis and expression screening in ovarian cancer cell lines were employed. Selected biomarkers were further validated in bio-specimens of diverse cancer types and ovarian cancer subtypes. For non-invasive detection, biomarker proteins were evaluated in serum samples from ovarian cancer patients.

RESULTS: Two kallikrein (KLK) serine protease family members (KLK6 and KLK7) were found to be significantly overexpressed relative to normal …

Spontaneous Asj-2j Mutant Mouse As A Model For Generalized Arterial Calcification Of Infancy: A Large Deletion/Insertion Mutation In The Enpp1 Gene., Qiaoli Li, C Herbert Pratt, Louise A Dionne, Heather Fairfield, Son Yong Karst, John P Sundberg, Jouni Uitto, Yin Tintut

Department of Dermatology and Cutaneous Biology Faculty Papers

Generalized arterial calcification of infancy (GACI), an autosomal recessive disorder caused by mutations in the ENPP1 gene, manifests with extensive mineralization of the cardiovascular system. The affected individuals in most cases die within the first year of life, and there is currently no effective treatment for this disorder. In this study, we characterized a spontaneous mutant mouse, asj-2J, as a model for GACI. These mice were identified as part of a phenotypic deviant search in a large-scale production colony of BALB/cJ mice at The Jackson Laboratory. They demonstrated a characteristic gait due to stiffening of the joints, with phenotypic similarity …

Toward An Improved Understanding Of The Ionizing Radiation Induced Dna Damage/Response Networks In Human Malignancies., Daphne A Haas-Kogan, David R Raleigh, Adam Paul Dicker

Department of Radiation Oncology Faculty Papers

No abstract provided.

Alternative Approaches To Lung Insults, Melpo Christofidou-Solomidou, Ph.D.

Division of Pulmonary, Allergy, and Critical Care Medicine Presentations and Grand Rounds

Objectives:

• Provide an understanding of current available botanical agents and their usefulness in lung disease;

• Provide an overview of current complementary approaches to lung disease and active areas of research in pre-clinical testing;

Overall Goals and Objectives:

Following this activity, a participant should be able to:

1. Recognize recent advances and developments in Pulmonary Medicine & Critical Care and translate into clinical practice

2. Integrate perspectives of multiple disciplines into decision-making on behalf of patients through structured plans for patient care.

3. Develop areas for future research and discuss appropriate methods to address these needs.

4. Summarize and continually …

Increasing The Degree To Which Evidence-Based Practice Is Carried Out By Ots At Magee Rehabilitation, Debra Zelnick, Otd, Otr/L

Department of Occupational Therapy Posters and Presentations

PICO Question:

Does in-service education on evidence-based practice provided to occupational therapists increase knowledge of the tools and resources necessary to become evidence-based practitioners?

Suppression Of Invasion And Metastasis Of Triple-Negative Breast Cancer Lines By Pharmacological Or Genetic Inhibition Of Slug Activity., Giovanna Ferrari-Amorotti, Claudia Chiodoni, Fei Shen, Sara Cattelani, Angela Rachele Soliera, Gloria Manzotti, Giulia Grisendi, Massimo Dominici, Francesco Rivasi, Mario Paolo Colombo, Alessandro Fatatis, Bruno Calabretta

Department of Cancer Biology Faculty Papers

Most triple-negative breast cancers (TNBCs) exhibit gene expression patterns associated with epithelial-to-mesenchymal transition (EMT), a feature that correlates with a propensity for metastatic spread. Overexpression of the EMT regulator Slug is detected in basal and mesenchymal-type TNBCs and is associated with reduced E-cadherin expression and aggressive disease. The effects of Slug depend, in part, on the interaction of its N-terminal SNAG repressor domain with the chromatin-modifying protein lysine demethylase 1 (LSD1); thus, we investigated whether tranylcypromine [also known as trans-2-phenylcyclopropylamine hydrochloride (PCPA) or Parnate], an inhibitor of LSD1 that blocks its interaction with Slug, suppresses the migration, invasion, and metastatic …

The New Oral Anticoagulants For The Treatment Of Venous Thromboembolism: A New Paradigm Shift In Antithrombotic Therapy., Taki Galanis, Gina Keiffer, Geno J Merli

Department of Medicine Faculty Papers

BACKGROUND: Several novel oral anticoagulants have been studied for the prevention and treatment of venous thromboembolism (VTE) in different patient populations. Clinicians will increasingly encounter scenarios in which they must choose among these and conventional anticoagulants for the treatment of this potentially fatal condition.

OBJECTIVE: To review the results of Phase III clinical trials that investigated the novel oral anticoagulants for the treatment of deep vein thrombosis and pulmonary embolism. Potential advantages and disadvantages of these anticoagulant agents with respect to each other and conventional therapy will also be explored through a case-based approach.

METHODS: A literature search in PubMed …

Pediatric Emergency Medical Care In Yerevan, Armenia: A Knowledge And Attitudes Survey Of Out-Of-Hospital Emergency Physicians., Aline A. Baghdassarian, Ross I. Donaldson, Andrew D Depiero, Nancy L Chernett, Harsh P. Sule Md

Department of Emergency Medicine Faculty Papers

BACKGROUND: Out-of-hospital emergency care is at an early stage of development in Armenia, with the current emergency medical services (EMS) system having emergency physicians (EPs) work on ambulances along with nurses. While efforts are underway by the Ministry of Health and other organizations to reform the EMS system, little data exists on the status of pediatric emergency care (PEC) in the country. We designed this study to evaluate the knowledge and attitudes of out-of-hospital emergency physicians in pediatric rapid assessment and resuscitation, and identify areas for PEC improvement.

METHODS: We distributed an anonymous, self-administered Knowledge and Attitudes survey to a …

Comprehensive Management Of The Paranasal Sinuses In Patients Undergoing Endoscopic Endonasal Skull Base Surgery., Gurston G Nyquist, Md, Marc R Rosen, Md, Mark E. Friedel, Md, D David Beahm, Md, Christopher J Farrell, Md, James J. Evans, Md

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

OBJECTIVE: The endonasal route often provides the most direct and safe approach to skull base pathology. In this article we review the literature with regard to management of the paranasal sinuses in the setting of skull base surgery.

METHODS: We describe our institutional experience and review the literature of concurrent management of the sinusitis in patients undergoing endoscopic skull base surgery.

RESULTS: Patients should be optimized preoperatively to ensure the endonasal route is a safe corridor to enter the intracranial cavity. Often the paranasal sinuses can be surgically addressed at the same time as endoscopic skull base surgery. We describe …

Current Therapeutic Research Is Now Indexed On Pubmed., John N Van Den Anker, Karel Allegaert, Walter K. Kraft

Department of Pharmacology and Experimental Therapeutics Faculty Papers

No abstract provided.

Plumbing And Wiring: Atherosclerosis In Epilepsy., Scott Mintzer, Md

Department of Neurology Faculty Papers

Over the long term, epilepsy is clearly associated with cognitive impairment. This has been demonstrated functionally, using neuropsychological testing, and reinforced by structural studies showing progressive atrophy in patients with chronic epilepsy ^1-3. The prevailing explanation for this, of course, has been the direct and cumulative effects of seizures on the brain. The basic science literature is chock full of studies showing impairment of neuronal function after seizures, both acutely and chronically. And for those of us who see patients, the progressive memory complaints and clear-cut decline in function seen in those with drug-resistant epilepsy — particularly temporal lobe …

Hyperthermia, Radiation And Chemotherapy: The Role Of Heat In Multidisciplinary Cancer Care., Mark Hurwitz, Md, Paul R. Stauffer

Department of Radiation Oncology Faculty Papers

The compelling biologic basis for combining hyperthermia with modern cancer therapies including radiation and chemotherapy was first appreciated nearly half a century ago. Hyperthermia complements radiation as conditions contributing to radio-resistance generally enhance sensitivity to heat and sensitizing effects occur through increased perfusion/tumor oxygenation and alteration of cellular death pathways. Chemosensitization with hyperthermia is dependent on the particular mechanism of effect for each agent with synergistic effects noted for several commonly used agents. Clinically, randomized trials have demonstrated benefit including survival with the addition of hyperthermia to radiation or chemotherapy in treatment of a wide range of malignancies. Improvements in …

2014 Jcipe Conference, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

The internationally-renowned Jefferson Center for Interprofessional Education (JCIPE) hosted a conference, Interprofessional Care for the 21st Century: Redefining Education and Practice, in Philadelphia on October 10-12, 2014. Conference presentations and posters have been loaded in the Jefferson Digital Commons.

The Emerging Roles Of Gprc5a In Diseases., Honglei Zhou, Isidore Rigoutsos

Computational Medicine Center Faculty Papers

The 'Retinoic Acid-Inducible G-protein-coupled receptors' or RAIG are a group comprising the four orphan receptors GPRC5A, GPRC5B, GPRC5C and GPRC5D. As the name implies, their expression is induced by retinoic acid but beyond that very little is known about their function. In recent years, one member, GPRC5A, has been receiving increasing attention as it was shown to play important roles in human cancers. As a matter of fact, dysregulation of GPRC5A has been associated with several cancers including lung cancer, breast cancer, colorectal cancer, and pancreatic cancer. Here we review the current state of knowledge about the heterogeneity and evolution …

Exploring Attitudes Toward Physician-Nurse Collaboration Within A Team-Based Primary Care Environment, Tom Karagiannis Pharmd, C. Coschignano, Sarah E. Hegarty Mphil, L. Polenzani, E. Messina, R. Zoli, Mohammadreza Hojat Phd, Vittorio Maio Pharmd,Msph

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Pharmacists On The Front Lines Of Community Health: The Pneumonia Prevention Project, Joseph Fulginiti, Jason Schafer Pharmd, Mph, Marie-Monique Marthol-Clark, Lynn Fields Harris Mpa, Joseph Desimone Jr, Md, Laura T. Pizzi Pharmd, Mph

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

My Shark Tank Experience: Inventing Tools For Population Health, Robert Lieberthal Phd

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

The Long Non-Coding Rna Pcat-1 Promotes Prostate Cancer Cell Proliferation Through Cmyc., John R. Prensner, Wei Chen, Sumin Han, Matthew K. Iyer, Qi Cao, Vishal Kothari, Joseph R. Evans, Karen E. Knudsen, Michelle T. Paulsen, Mats Ljungman, Theodore S. Lawrence, Arul M. Chinnaiyan, Felix Y. Feng

Department of Cancer Biology Faculty Papers

Long non-coding RNAs (lncRNAs) represent an emerging layer of cancer biology, contributing to tumor proliferation, invasion, and metastasis. Here, we describe a role for the oncogenic lncRNA PCAT-1 in prostate cancer proliferation through cMyc. We find that PCAT-1-mediated proliferation is dependent on cMyc protein stabilization, and using expression profiling, we observed that cMyc is required for a subset of PCAT-1-induced expression changes. The PCAT-1-cMyc relationship is mediated through the post-transcriptional activity of the MYC 3' untranslated region, and we characterize a role for PCAT-1 in the disruption of MYC-targeting microRNAs. To further elucidate a role for post-transcriptional regulation, we demonstrate …