Medicine and Health Sciences Commons^™

Conference Poster Season, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

The Jefferson Digital Commons (JDC) has nearly 500 archived conference posters. Don’t let your conference posters collect dust and sit in hallways where only your colleagues view them on a daily basis. Send them to the JDC to reach a global audience.

Inflammatory Muscle Diseases., Marinos C Dalakas

Department of Neurology Faculty Papers

No abstract provided.

Inside Out, Spring 2015

Inside Out

Contents:

Checkmate, Joshua Cannon, 1

Contort, Michael Natter, 2

For Vastness’ Sake, Marc McShane, 3

Old Country Road, Jonathan Elias, 4

Dippers, Ethan Sellers, 5

A Liberated Caravan, Tanziyah Muqeem, 6

To be, or Not to be, Danylo I. Holubnyk, 7

San Francisco, 2009, Sina Vahedi, 8

Tranquil Days, David Chou, 9

Living, Marc McShane, 10

Never Too Early for a Nap, Tuc To, 11

Reclining Nude, Chen Zhou,12

Peace Crane, Lauren Burgoon, 13

Untitled Hand, Amanda Joseph, 14

Japan Memorial, Lauren Burgoon, 15

The Clearing Storm, Eric W. Kostuk, 16

Wild Flowers, Amanda Joseph, 17

Female Nudes, Elise Campbell, …

Inside Out, Spring 2014

Inside Out

Contents

Angkor Thom: City of a Thousand Smiling Faces, Miranda G. Law, 1

Exposed Jade, Kami L. McManus, 2

Cheerleader Graffiti, Ethan Sellers, 3

Inca Beauty, Amy Tressan, 4

Ethereal, David Chou, 5

A Reflection, Sepehr Sedigh, 6

Mediumship, Michael Joseph Kolachny, Jr., RN 7

The Native Inspiration, Sepehr Sedigh, 8

Elephant, Julia Huntington, 9

Unrequited Love, Amy Tressan, 10

Wait, Nona Lu, 11

Clouds with Secrets, Amy Tressan, 12

Thunderstrike in Camden, Yuhang Zhou, 13

Crash, Diway Bermudez, 14

At Dusk I Carry Stones..., Ethan Sellers, 15

Docks at Jaffa, Kami L. McManus, 16

The Pier, David Chou, 17 …

Inside Out, Spring 2013

Inside Out

Contents:

Imp of the Perverse, Evan J. Slagle

Mom, Ethan Sellers

Curves of the Albatross, Christina Nguyen

Colors, Sarah Drejet

Rajasthan, India, Nishi Dedania

Heights that I Remember, Daniel Gealy

Girl in Transit, Michela Mickler

Chemo, Emily Fay

Energy, Dierdre Axell-House

African Dreaming, Michela Mickler

Flight, Michela Mickler Rittenhouse

Reflections, Kami L. McManus

Lovers in Washington Square, Wendy Diao

No Agenda, Laura Steel

I’ve Come to Know Sepia, Ethan Sellers

Re-imagine-d, Jonathan Elias

Glee, Rebecca Julian

A Creature Void of Form, Daniel Gealy

The Column, Emily Fay

Bold, Bald, Black & White, Dierdre Axell-House

Salar de Uyuni, Bolivia Nicholas Bishop …

Inside Out, Spring 2012

Inside Out

Contents

Limbless, Desmond Wilson, Cover

The Daily Grind, Dave Miller, Inside Cover

The Sea Conqueror, Jonathan Elias, 5

Fear, Yuliya Baratt, 5

Dreamer Mosaic, Huong Le, 6

The Colored White Desert of Egypt, MIranda Law, 6

The Hands of My First Autopsy, Nathan Fried, 7

Esperar, Neil Flannery Haidorfer, 8

Retrograde Frequency, Evan Slagle, 9

Childhood, Yuliya Baratt, 9

Flying South for the Winter, Nishi Dedania, 10

Barn in Winter, Michael Minckler, 10

Mountain Goat, Alissa Herman, 11

Tree Burr, Nate Jordan, 11

Wake, Andrea Frankenburger, 12

Mt. Rainier Viewed from Seattle, WA, Michael Minckler, 12

Sisterhood, Sharon Li, 13 …

Inside Out, Spring 2011

Inside Out

Contents:

Winter Boardwalk, Heather Tattersall, 1

Boundaries, Kanani Titchen, 2

Nightline, To Dung Nguyen, 4

Blue Jeans, Bonnie Bennet, 5

After the Genocide, Rwanda, Christine Chen, 6

Trails, Matt Richards, 7

Various Facades, Subhasree Basu, 8

On Our Mistakes, and Physics, Khalid Mohamood, 9

Valle Sagrado, Lara Murphy, 11

Pink Study, Han Koon Ooi, 12

Passage, Rites, Jennifer Lewis, 13

Layers, Mara Modest, 15

Heather Tattersall, Aivi Nguyen, 16

Pulse, Christina Furia, 17

Penmanship, Christina Nguyen, 18

Small Jeffersonians, Francina Girard, 19

Growing Up In Guatemala, Christine Chen, Front Cover

Lady Watering, Aimee J. Lee, Inside Front Cover

Singed, Matt …

Eleven Years Of Data On The Jefferson Scale Of Empathy-Medical Student Version (Jse-S): Proxy Norm Data And Tentative Cutoff Scores., Mohammadreza Hojat, Joseph S. Gonnella

Department of Psychiatry and Human Behavior Faculty Papers

OBJECTIVE: This study was designed to provide typical descriptive statistics, score distributions and percentile ranks of the Jefferson Scale of Empathy-Medical Student version (JSE-S) of male and female medical school matriculants to serve as proxy norm data and tentative cutoff scores.

SUBJECTS AND METHODS: The participants were 2,637 students (1,336 women and 1,301 men) who matriculated at Sidney Kimmel (formerly Jefferson) Medical College between 2002 and 2012, and completed the JSE at the beginning of medical school. Information extracted from descriptive statistics, score distributions and percentile ranks for male and female matriculants were used to develop proxy norm data and …

Latest School Of Population Health Capstones In The Jdc, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

The latest round of capstone presentations by students in the TJU School of Population Health have been loaded in the Jefferson Digital Commons.

Relationship Between Motor Symptoms, Cognition, And Demographic Characteristics In Treated Mild/Moderate Parkinson's Disease., Jay S Schneider, Stephanie Sendek, Chengwu Yang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Although Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized primarily by motor symptoms, PD patients, at all stages of the disease, can experience cognitive dysfunction. However, the relationships between cognitive and motor symptoms and specific demographic characteristics are not well defined, particularly for patients who have progressed to requiring dopaminergic medication.

OBJECTIVE: To examine relationships between motor and cognitive symptoms and various demographic factors in mild to moderate, PD patients requiring anti-PD medication.

METHODS: Cognitive function was assessed in 94 subjects with a variety of neuropsychological tests during baseline evaluations as part of an experimental treatment study. Data …

Cross-Cultural And Inter-Professional Knowledge Translation Of Developmentally Supportive Care In An Indian Nicu, Amy Carroll, Otd, Otr/L, Susan Toth-Cohen, Phd, Otr/L

Department of Occupational Therapy Posters and Presentations

Synopsis:

A cross-cultural, and inter-professional NICU Team, including an American OT, used knowledge translation (KT) frameworks to apply current global evidence in developmentally supportive care in ways that were useful, cost effective, and meaningful to the families and staff in their tertiary care NICU setting in Gurgaon, India. The team used Pre & Post videotaping of routine care and procedures to measure the change in practice.

Objectives

1. Increase NICU nurses’ use of DSC during routine care and procedures

2. Decrease the use of non-supportive behaviors

Embedding Mindfulness Practice In Entry-Level Occupational Therapy Education Program: Experiences And Outcomes, Mary Muhlenhaupt, Otd, Otr/L, Faota, Shelly Wallock, Dr.P.H., Otr/L

Department of Occupational Therapy Posters and Presentations

Objective:

To embed mindfulness practice into an entry-level occupational therapy curriculum and assess outcomes to reduce student stress and promote well-being.

Kinase-Independent Role Of Cyclin D1 In Chromosomal Instability And Mammary Tumorigenesis., Mathew C Casimiro, Gabriele Disante, Marco Crosariol, Emanuele Loro, William Dampier, Adam Ertel, Zuoren Yu, Elizabeth A Saria, Alexandros Papanikolaou, Z Li, Chenguang Wang, Sankar Addya, Michael P. Lisanti, Paolo Fortina, Robert D Cardiff, Aydin Tozeren, Erik S Knudsen, Andrew Arnold, Richard Pestell

Department of Cancer Biology Faculty Papers

Cyclin D1 is an important molecular driver of human breast cancer but better understanding of its oncogenic mechanisms is needed, especially to enhance efforts in targeted therapeutics. Currently, pharmaceutical initiatives to inhibit cyclin D1 are focused on the catalytic component since the transforming capacity is thought to reside in the cyclin D1/CDK activity. We initiated the following study to directly test the oncogenic potential of catalytically inactive cyclin D1 in an in vivo mouse model that is relevant to breast cancer. Herein, transduction of cyclin D1-/- mouse embryonic fibroblasts (MEFs) with the kinase dead KE mutant of cyclin D1 led …

Experiential Global Health Education For The Health Professions: Lessons Learned From Experience-Based Learning For Students And Healthcare And Population Health Professionals, Rob Simmons, Drph, Mph, Mches, Cph, James Plumb, Md, Mph, Lucille Pilling, Edd, Mph, Rn, Ellen Plumb, Md

College of Population Health Lectures, Presentations, Workshops

Purpose:

• Describe key components of developing and sustaining a global health experiential learning experience

• Global Health Education for the Health Professions
• An area for multi-disciplinary study, research, and practice that places priority on achieving equity in health for all people worldwide
• Emphasizes transnational health issues, determinants, and solutions that promote interdisciplinary collaboration providing a synthesis of population based prevention, often including individual-level education and healthcare

Assessment For Risk Factors Associated With Local Recurrence In Chordoma, John A. Abraham, Md, Wei Jiang, Md, Phd

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background

Chordoma is a rare but locally aggressive malignant neoplasm showing notochordal differentiation. The clinical differential diagnoses can be extensive, and definitive diagnosis often relies on histopathologic evaluation. Histologically, chordoma shows dual epithelial and mesenchymal differentiation, with various morphologies. Despite surgical resection and use of adjuvant radiation therapy, the local recurrence rate of chordoma remains high. We aim to establish factors associated with the increased risk of recurrence and help guide treatment decisions.

Loss Of Expression Of Swi/Snf Chromatin Remodeling Complex Components And Setd2 Are Heterogeneous, Widespread, And Co-Occur In Clear Cell Renal Cell Carcinoma, Wei Jiang, Md, Phd, Essel Dulaimi, Theodore Parsons, Qiong Wang, Karthik Devarajan, Raymond O'Neill, Charalambos C. Solomides, Md, Stephen C Peiper, Phd, Jospeh R. Testa, Robert Uzzo, Haifeng Yang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background

The subunits of the SWI/SNF chromatin remodeling complex have one of the highest mutation rate in human cancers (see Figure 1). Polybromo-1 (PBRM1), a subunit of the SWI/SNF complex, is the second most mutated gene (40%) in clear cell Renal Cell Carcinoma (ccRCC). ARID1A, another subunit that competes with PBRM1 for binding to the complex, was infrequently mutated. The protein expressions of BRG1 and BRM (two catalytic subunits of the complex), and SETD2, a histone modifier (10-15% mutation rate), are not known in ccRCC. In this study we examined their protein expressions by immunohistochemistry (IHC) in tissue microarrays (TMAs), …

Age-Related Ebv-Associated Lymphoproliferative Disorder With Widespread Gastrointestinal Involvement And Subsequent Development Of T-Cell Lymphoma, Guldeep Uppal, Md, Alaina Chodoff, Msii, Zi-Xuan Wang, Phd, Jeffrey P. Baliff Md, Jerald Z. Gong, Md

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background

Age-related EBV-associated lymphoproliferative disorder (AR-EBVLPD) has emerged as a new subset of B-cell lymphoproliferative disorders. We report a unique case of AR-EBVLPD with a widespread gastrointestinal presentation and subsequent transformation to EBV-associated T-cell lymphoma. To our knowledge, this is the first report of a generalized polymorphic extranodal AR-EBVLPD with subsequent transformation to EBV-induced T-cell lymphoma.

An Assessment Of The Reliability Of Platelet-Associated Flags Generated By The Sysmex Xe-5000 Automated Hematology Analyzer In Detecting Platelet Clumps, Jennifer M. Hawkins, Do, Gene Gulati, Ph.D, Guldeep Uppal, Md, Jerald Z. Gong, Md

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background

XE-5000 is an automated hematology analyzer utilized by clinical laboratories worldwide to perform CBC and differential leukocyte counts on EDTA-anticoagulated blood specimens. The overall reliability of the results generated by this analyzer has been assessed and found acceptable for clinical use. The CBC results generated on some of the blood specimens are, however, flagged by the analyzer for verification of the result of the flagged parameter by other means. One such parameter of clinical significance is the automated platelet count, which is often unreliable if the blood specimen contains platelet clumps.

Pathology Encountered During Cadaver Dissection Provides An Opportunity For Integrated Learning And Critical Thinking, Guiyan Zhang, Bruce Fenderson

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Abstract

Cadaver dissection engages medical students in active learning, critical thinking, and problem solving. During dissection, students at SKMC are encouraged to document pathologic findings in their cadavers and discuss the findings with their peers. Here, we describe two cases that provided opportunities for integrating anatomy with pathology and clinical medicine. The first case was a benign ovarian neoplasm. This large pelvic mass displaced the urinary bladder and uterus, and compressed the ureters and rectum. Students discussed clinical complications of this pelvic mass and reviewed pathologic findings that differentiate benign from malignant neoplasms. The second case was breast cancer with …

Phylogenetic Tree Construction And “Truncal Loss” Analysis Reveal Hidden Associations Between Loss Of Protein Expression In Swi/Snf Complex Components And Tumor Stage And Survival In Clear Cell Renal Cell Carcinoma (Ccrcc), Wei Jiang, Md, Phd, Essel Dulaimi, Karthik Devarajan, Qiong Wang, Raymond O'Neill, Charalambos C. Solomides, Md, Stephen C Peiper, Phd, Robert Uzzo, Joseph R. Testa, Haifeng Yang, Phd

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background

Polybromo-1 (PBRM1), a targeting subunit of the SWI/SNF chromatin remodeling complex, is mutated at a rate of ~40% in clear cell Renal Cell Carcinoma (ccRCC), second only to VHL. Whether its mutation is correlated with tumor stage is controversial. As other components of the SWI/SNF complex were also reported to be mutated in ccRCC, we aim to examine the protein expression patterns of PBRM1, ARID1A, BRG1, and BRM in ccRCC, and to investigate possible association between their loss of expression and tumor stage, as well as survival. We also included a histone modifier, SETD2, which is recently discovered to …

Polymorphisms In Genes Of Tricarboxylic Acid Cycle Key Enzymes Are Associated With Early Recurrence Of Hepatocellular Carcinoma., Shaogui Wan, Yousheng Wu, Xingchun Zhou, Yibing Chen, Jiaze An, Xiaohe Yu, Huiqing Zhang, Hushan Yang, Jinliang Xing

Department of Medical Oncology Faculty Papers

Alterations of activity and expression in tricarboxylic acid (TCA) cycle key enzymes have been indicated in several malignancies, including hepatocellular carcinoma (HCC). They play an important role in the progression of cancer. However, the impact of single nucleotide polymorphisms (SNPs) in genes encoding these key enzymes on the recurrence of HCC has not been investigated. In this study, we genotyped 17 SNPs in genes encoding TCA cycle key enzymes and analyzed their association with recurrence-free survival (RFS) in a cohort of 492 Chinese HCC patients by Cox proportional hazard model and survival tree analysis. We identified 7 SNPs in SDHC, …

Crosstalk Between Desmoglein 2 And Patched 1 Accelerates Chemical-Induced Skin Tumorigenesis., Donna M Brennan-Crispi, Claudia Hossain, Joya Sahu, Mary Brady, Natalia A Riobo, M G Mahoney

Department of Biochemistry and Molecular Biology Faculty Papers

Aberrant activation of Hedgehog (Hh) signaling is causative of BCCs and has been associated with a fraction of SCCs. Desmoglein 2 (Dsg2) is an adhesion protein that is upregulated in many cancers and overexpression of Dsg2 in the epidermis renders mice more susceptible to squamous-derived neoplasia. Here we examined a potential crosstalk between Dsg2 and Hh signaling in skin tumorigenesis. Our findings show that Dsg2 modulates Gli1 expression, in vitro and in vivo. Ectopic expression of Dsg2 on Ptc1+/lacZ background enhanced epidermal proliferation and interfollicular activation of the Hh pathway. Furthermore, in response to DMBA/TPA, the Dsg2/Ptc1+/lacZ mice developed squamous …

An Interprofessional, Tailored Behavioral Intervention For Sleep Problems In Autism: Use Of Sensory Data To Inform Intervention, Rebecca Sinko, Ms, Otr/L, Sarah E. Kauper, Bs, Ots, Phoi Truong, Bs, Ots, Rachel L. Dumont, Bs, Ots, Amy L. Miller, Bs, Ots, Roseann C. Schaaf, Phd, Otr/L, Faota, Margaret Souders, Phd, Crnp, Eric D. Bull, Ots, Denise G. Doria, Ots, Jamie A. Frank, Ots, Jenna R. Grady, Ots

Department of Occupational Therapy Posters and Presentations

Purpose:

The purpose of this poster is to demonstrate how Sensory Profile data informed occupational therapy sleep interventions for two participants as part of an Interprofessional Tailored Behavioral Intervention study.

Occupational Therapy And Family Caregiver Training: The Key To Successful Dementia Care, Catherine V. Piersol, Phd, Otr/L, Ann O'Sullivan, Otr/L, Lsw, Faota

Department of Occupational Therapy Posters and Presentations

Most people with Alzheimer’s disease and related disorders live in the community and are cared for by family caregivers who have not received formal training. Evidence has shown that caregiving can have profound negative effects on a caregiver’s own physical and psychological health, including increasing social isolation and decreasing quality of life and wellbeing. If the demands of care exceed the caregiver’s capacity, the person with dementia can also be negatively affected. Research supports the effectiveness of teaching caregivers approaches that match the skills and interests of the person with dementia, use appropriate cues, identify and modify behavioral triggers, and …

Parents' Goals: An Analysis Of Therapist Reasoning, Amy L. Miller, Ots, Rachel L. Dumont, Ots, Janice P. Burke, Phd, Otr/L, Faota, Ellen S. Cohn, Scd, Otr/L, Faota, Sarah E. Kauper, Ots, Roseann C. Schaaf, Phd, Otr/L, Faota, Eric D. Bull, Ots, Denise G. Doria, Ots, Jamie A. Frank, Ots, Jenna R. Grady, Ots, Phoi Truong, Ots

Department of Occupational Therapy Posters and Presentations

Purpose:

Illustrate the use of DDDM to develop parent-identified goals for occupational therapy and to identify underlying sensory integration factors hypothesized to be impacting participation.

The Ot's Role In An Interprofessional Research Team, Sara Benham, Otd, Otr/L, Atp, Susan Toth-Cohen, Phd, Otr/L

Department of Occupational Therapy Posters and Presentations

Why Interprofessional Research?

The research field receives contributions from multiple disciplines and is inclusive by nature. •Feels natural in our day to day work practices to collaborate with other professions. •A plan to build research capacity includes establishing a research culture, environment, and infrastructure as well as partnership with other disciplines (Frontera et al., 2006).

Routine Surveillance Of Patients With Hypertensive Disorders In Pregnancy, Johanna Quist-Nelson, Md, Lauren Cooper, Md, Abigail Wolf, Md

Department of Obstetrics and Gynecology Presentations and Grand Rounds

BACKGROUND

• Hypertensive disorders in pregnancy carry morbidity and mortality for mothers and infants
• Hypertensive disorders include a full spectrum from gestational hypertension and preeclampsia to eclampsia.
• In 2013 the American College of Obstetricians and Gynecologists released an executive summary with new task force recommendations for closer monitoring of patients with hypertensive disorders including:

Twice weekly blood pressure monitoring

Weekly office visits

Ultrasound surveillance of fetal growth

Weekly laboratory surveillance

Delivery at 37 weeks for patients with gestational hypertension and preeclampsia without severe features

Pt/Ot Students Experience Working At Overnight Camp For Children With Disabilities, Audrey L. Zapletal, Ms, Otr/L, David A. Lehman, Phd, Pt

Department of Occupational Therapy Posters and Presentations

Objectives:

• Describe the innovative interprofessional field experience
• Discuss how the camp program enhances the OT/PT students’ skills towards interprofessional practice and discipline specific clinical reasoning
• Examine how this opportunity has influenced OT/PT students’ educational and professional development

Perceptions Of Neonatal Nurse Practitioner Role Among Nicu Nurses, Michele K. Savin, Msn, Nnp-Bc

College of Nursing Faculty Papers & Presentations

Purpose: The purpose of this project was to examine Neonatal Intensive Care Unit (NICU) nurses’ perceptions of the NNP role and barriers to entering the role.

Background: A shortage of neonatal nurse practitioners (NNPs) exists. Hiring NNPs from outside the current NICU staff has resulted in turnover and additional cost. If current nursing staff prepared as NNPs, the organization would benefit; yet few nurses have done so. Reasons that dissuade nurses from pursuing the NNP role have not been adequately examined. Knowing how nurses perceive the NNP role may help to decrease barriers and inform plans to address the problem.

A Descriptive Study Of Non Traditional School Health Delivery; Funding Sources, Outcomes And Staff Configurations, Sherri Becker, Msn, Mba, Rn, Erin D. Maughan, Phd, Ms, Rn, Aphn-Bc, June Horowitz, Phd, Rn, Faan

College of Nursing Faculty Papers & Presentations

Background:

1) The traditional funding for school nursing has been educational dollars.

2) As school district budgets tighten, the number of students with health needs continues to rise and the Affordable Care Act (ACA) puts increased emphasis on community care, new school health delivery models are emerging.

3) There is limited study in this area. Anecdotal stories of wide variability exist.