Medicine and Health Sciences Commons^™

Developments In Neurovascular Diseases And Treatments., Robert M Starke, Stephen J Monteith, Andrew M Southerland, R Webster Crowley, Nohra Chalouhi, Dale Ding, David M Hasan, Aaron S Dumont

Department of Neurosurgery Faculty Papers

No abstract provided.

Treatment-Induced Changes In Plasma Adiponectin Do Not Reduce Urinary Albumin Excretion In The Diabetes Prevention Program Cohort., Kieren J Mather, Qing Pan, William C Knowler, Tohru Funahashi, George A Bray, Richard Arakaki, Bonita Falkner, Kumar Sharma, Barry J. Goldstein

Department of Medicine Faculty Papers

BACKGROUND AND OBJECTIVES: Molecular data suggests that adiponectin may directly regulate urinary albumin excretion. In the Diabetes Prevention Program (DPP) we measured adiponectin and albuminuria before and after intervention, and we previously reported increases in adiponectin with interventions. Here we have used the DPP dataset to test the hypothesis that treatment-related increases in adiponectin may reduce albuminuria in obesity.

DESIGN, SETTING, PARTICIPANTS AND METHODS: We evaluated cross-sectional correlations between plasma adiponectin and urinary albumin excretion at baseline, and the relationship of treatment-related changes in adiponectin and albuminuria. Baseline and follow-up urine albumin to creatinine ratios (ACR (albumin to creatinine ratio)) …

Communication Skills Training For Patients And Healthcare Providers: A Proposed Blend Of Performance Studies, Theatre, And Communication Strategies, Rachel Thomas Mph, Pamela Zubow Poe Phd

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

The 24th Annual Dr. Raymond C. Grandon Lecture: Building A Culture Of Health In America

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Honoring The University Of Delaware Medical Scholar Graduates

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

The Stephen Klein Wellness Center As A Community-Centered Health Home - A Partnership Between Jefferson And Project Home, James D. Plumb Md, Mph, Lara Weinstein Md, Mph, Monica Mccurdy Pa-C, Mhs

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

The Generation Of Transformation, Stephen Klasko Md, Mba

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Atomic Structure Of Grk5 Reveals Distinct Structural Features Novel For G Protein-Coupled Receptor Kinases, Konstantin E. Komolov, Anshul Bhardwaj, Jeffrey L. Benovic

Department of Biochemistry and Molecular Biology Faculty Papers

G protein-coupled receptor kinases (GRKs) are members of the protein kinase A, G, and C families (AGC) and play a central role in mediating G protein-coupled receptor phosphorylation and desensitization. One member of the family, GRK5, has been implicated in several human pathologies, including heart failure, hypertension, cancer, diabetes, and Alzheimer disease. To gain mechanistic insight into GRK5 function, we determined a crystal structure of full-length human GRK5 at 1.8 Å resolution. GRK5 in complex with the ATP analog 5'-adenylyl β,γ-imidodiphosphate or the nucleoside sangivamycin crystallized as a monomer. The C-terminal tail (C-tail) of AGC kinase domains is a highly …

Differential Host Immune Responses After Infection With Wild-Type Or Lab-Attenuated Rabies Viruses In Dogs., Clement W Gnanadurai, Yang Yang, Ying Huang, Zhenguang Li, Christina M Leyson, Tanya L Cooper, Simon R Platt, Stephen B Harvey, D Craig Hooper, Milosz Faber, Zhen F Fu

Department of Medical Genetics Faculty Papers

METHODOLOGY/PRINCIPAL FINDINGS: The experimental infection of dogs with TriGAS induced high levels of VNA in the serum, whereas wt RABV infection did not. Dogs infected with TriGAS developed antibodies against the virus including its glycoprotein, whereas dogs infected with DRV-NG11 only developed rabies antibodies that are presumably specific for the nucleoprotein, (N) and not the glycoprotein (G). We show that infection with TriGAS induces early activation of B cells in the draining lymph nodes and persistent activation of DCs and B cells in the blood. On the other hand, infection with DRV-NG11 fails to induce the activation of DCs and …

Locomotor Adaptation Is Influenced By The Interaction Between Perturbation And Baseline Asymmetry After Stroke., Christine M. Tyrell, Erin Helm, Darcy S. Reisman

Department of Physical Therapy Faculty Papers

Stroke survivors without cerebellar involvement retain the ability to adapt to the split-belt treadmill; however it has been suggested that their rate of adaptation may be slowed compared to those who are neurologically intact. Depending on limb placement, the split-belt treadmill can be configured to either exaggerate baseline asymmetry, or reduce it, which may affect the behavior of adaptation or de-adaptation. The objectives of this study were to characterize the rate and magnitude of locomotor (de)adaptation in chronic stroke survivors compared to healthy matched subjects, and to evaluate whether exaggeration or reduction of baseline asymmetry impact the responses. Seventeen stroke …

Using Interprofessional Education & Simulation-Based Learning In Health Profession Curricula To Improve Competence & Confidence: A Systematic Review, Danielle Elfand, Ots, Briana Elson, Ots, Courtney Hudson, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Objectives of Presentation:

● Describe the types of interprofessional education (IPE) simulation-based learning experiences in current health professions curricula.

● Discuss benefits for implementation of IP simulation into pre-licensure health profession programs.

● Explain how IP simulation-based learning improves workforce competency and confidence in entry-level health

● professionals.

PICO: What is the impact of interprofessional education simulation activities in improving workforce competency and confidence in entry level health professionals?

Presentation: 44 minutes

I Think Therefore I Can. A Systematic Review Of Metacognitive Strategies And Their Impact On Occupational Performance In Adults Following Stroke, Kerry Canton, Ots, Chelsea Difrancesco, Ots, Christy Geaney, Ots, Sarah Jamieson, Ots, Jessica Talarico, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Objectives of Presentation:

1. Explain the role of metacognition in everyday activities

2. Discern the quality of evidence regarding metacognitive strategies in adults who have sustained a stroke.

3. Conceptualize a metacognitive intervention to utilize within stroke rehabilitation based on the evidence

presented in this session.

PICO: What is the evidence for the impact of metacognitive interventions on occupational performance in adults who have sustained a stroke?

Presentation: 43 minutes

Reach For The Stars: Improving Upper Extremity Function After Spinal Cord Injury, Carlisle Bland, Ots, Molly Bucciero, Ots, Shelby Hankins, Ots, Blair Krevitz, Ots, Nicole Matyas, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Objectives of Presentation:

1.) Describe how cervical spinal cord injury affects UE functioning necessary for activities of daily living.

2.) Describe occupational therapy interventions used to increase UE functioning in cervical SCI.

3.) Discuss how current evidence supports implementing occupational therapy interventions into clinical practice for individuals with cervical SCI, in order to maximize independence in activities of daily living.

PICO: What is the evidence supporting occupational therapy interventions to increase upper extremity function in order to improve ADL performance following Cervical Spinal Cord Injury?

Presentation: 42 minutes

Promoting Quality Of Life For Individuals With Huntington’S Disease, Lyndsay Gentile, Ots, Mallory Koch, Ots, Elyse Mccabe, Ots, Jessica Royal, Ots, Sarah Sadofsky, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Objectives of Presentation:

 Describe the symptoms of Huntington’s disease and their impact on functional performance.

 Recognize the role of occupational therapy in improving quality of life for individuals with Huntington’s disease.

 Discuss how occupational therapy interventions for individuals with Huntington’s disease can be applied in a variety of settings.

Clinical Question:

What is the effectiveness of occupational therapy interventions in improving quality of life for individuals with Huntington’s disease?

Presentation: 46 minutes

Early Mobilization In The Intensive Care Unit (Icu): A Systematic Review, Lara Belasco, Ots, Shannon Dixon, Ots, Nina Pesce, Ots, Jennifer Wong, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Learning Objectives:

At the conclusion of the session, the learner will be able to:

1. Explain early mobilization techniques in the Intensive Care Unit (ICU)

2. Identify the role of occupational therapy in the ICU

3. Discuss the implications of early mobilization interventions for adults in the ICU

Clinical Question:

What are the effects of early mobilization on ADL performance for adults in the ICU?

Presentation: 42 minutes

A World Of Opportunities: Community Reintegration For Individuals With Brain Injury, Francine Gebbia, Ots, Amy Miller, Ots, Marianella Sanchez, Ots, Erica Serviolo, Ots, David Turoff, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Objectives of Presentation:

● Define community reintegration within the scope of occupational therapy

● Explain the importance of community reintegration for adults with a brain injury

● Discuss the effectiveness of occupational therapy interventions used to promote community reintegration

for adults with a brain injury

PICO:

What is the effectiveness of occupational therapy interventions in community reintegration for individuals with brain injury?

Presentation: 53 minutes

Back In The Saddle: A Systematic Review Of Occupational Therapy Interventions That Facilitate Return-To-Work, Preston W. Lockwood, Ots, Julie Luu, Ots, Brady Mcguire, Ots, Jay Skaria, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Objectives of Presentation:

1. Recognize the opportunity for injured workers, organizations, and society to benefit from occupational therapy interventions that improve return to work (RTW) outcomes.

2. Classify RTW occupational therapy interventions based on effectiveness.

3. Describe strategies to apply evidence-based interventions in current clinical practice.

PICO: What interventions within the scope of occupational therapy best facilitate return-to-work for adults with musculoskeletal disorders on workers compensation?

Presentation: 50 minutes

Interventions For Improving Occupational Performance Post-Concussion In Children And Adolescents: A Scoping Review, Abigail Gilmore, Ots, Amy Gottesman, Ots, Sarah Kauper, Ots, Michelle Malon, Ots, Brianna Schwoyer, Ots, Alisha Unternahrer, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Objectives of Presentation:

● Recognize the significant impact of concussion on immediate and long-term mental and physical well being in the pediatric population.

● Identify the need for novel and effective interventions that address the impact of pediatric concussions.

● Describe current concussion interventions and management practices and the gap that exists in the literature.

● Discuss interventions within the scope of OT practice to address occupational performance in children and adolescents post-concussion.

Clinical Question: What interventions within the scope of occupational therapy practice are indicated in the current literature to improve occupational performance in children and adolescents who have …

Making It Work: Individuals With Autism Spectrum Disorder And Adaptations For Successful Employment, Kelsey Curran, Julia Huntington, Amanda Siefert, Kristina Slog, Meagan Stromer, Kristina Toussaint

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Objectives of Presentation:

1. Discuss barriers to achieving successful postsecondary employment outcomes for individuals with Autism Spectrum Disorder.

2. Identify and describe evidence for adaptations that support individuals in post-secondary employment.

3. Interpret the clinical implications of the presented findings for occupational therapists, clinicians, educators, and researchers.

PICO: For individuals with Autism Spectrum Disorder (ASD), what adaptations effectively support postsecondary employment and/or job specific skills?

Methods:

• Developed a PICO question, identified databases, search terms, and inclusion and exclusion criteria

• Systematically searched databases using Scopus, ERIC (Ovid), & CINAHL and screened articles by title, abstract and full-text

•23 final …

Jefferson Digital Commons Redesign, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

The Jefferson Digital Commons has a new look. The site includes a new banner and layout to help researchers navigate the site.

10 New Jmc Yearbooks Added To The Jdc, Kelsey Duinkerken, Msi

Jefferson Digital Commons News

Jefferson Medical College yearbooks (published under various titles) are a rich source of Jefferson history. Scott Memorial Library and University Archives and Special Collections have been preserving the yearbooks by digitizing and uploading them to the Jefferson Digital Commons. Yearbooks from 1899 to 1960 were digitized previously and ten more years have been completed and added to the JDC in the latest phase of the project.

Disseminated Histiocytoses Biomarkers Beyond Brafv600e: Frequent Expression Of Pd-L1., Nurija Bilalovic, Juan P. Palazzo, Ryan P Bender, Jeffrey Swensen, Sherri Z Millis, Semir Vranic, Daniel Von Hoff, Robert J Arceci, Zoran Gatalica

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The histiocytoses are rare tumors characterized by the primary accumulation and tissue infiltration of histiocytes and dendritic cells. Identification of the activating BRAFV600E mutation in Erdheim-Chester disease (ECD) and Langerhans cell histiocytosis (LCH) cases provided the basis for the treatment with BRAF and/or MEK inhibitors, but additional treatment options are needed. Twenty-four cases of neoplastic histiocytic diseases [11 extrapulmonary LCH, 4 ECD, 4 extranodal Rosai-Dorfman disease (RDD), 3 follicular dendritic cell sarcoma (FDCS), 1 histiocytic sarcoma (HS) and 1 blastic plasmacytoid dendritic cell neoplasm (BPDCN)] were analyzed using immunohistochemical and mutational analysis in search of biomarkers for targeted therapy. BRAF …

Medical Library Association Historical Marker To Be Installed In Philadelphia, June H. Fulton, Fmla, Daniel G. Kipnis, Msi

Academic Commons and Scott Memorial Library Staff Papers and Presentations

During 2015, its 117th anniversary year, MLA will celebrate a novel and permanent way of informing both residents and visitors to Philadelphia about the association. Several months ago, the Pennsylvania Historical and Museum Commission voted to approve the nomination of an official State Historical Marker to commemorate MLA's founding in Philadelphia in 1898. The text of the marker will not be revealed until the marker's dedication ceremony in keeping with the commission's guidelines.

Skmc Student Handbook 2015-2016, Thomas Jefferson University

Jefferson Medical College Administrative Documents and Reports

71 page student handout

Structure-Based Screen Identifies A Potent Small Molecule Inhibitor Of Stat5a/B With Therapeutic Potential For Prostate Cancer And Chronic Myeloid Leukemia., Zhiyong Liao, Lei Gu, Jenny Vergalli, Samanta A. Mariani, Marco De Dominici, Ravi K. Lokareddy, Ayush Dagvadorj, Puranik Purushottamachar, Peter A. Mccue, Edouard J. Trabulsi, Costas D. Lallas, Shilpa Gupta, Elyse Ellsworth, Shauna Blackmon, Adam Ertel, Paolo Fortina, Benjamin E. Leiby, Guanjun Xia, Hallgeir Rui, David T. Hoang, Leonard G Gomella, Gino Cingolani, Vincent Njar, Nagarajan Pattabiraman, Bruno Calabretta, Marja T. Nevalainen

Department of Cancer Biology Faculty Papers

Bypassing tyrosine kinases responsible for Stat5a/b phosphorylation would be advantageous for therapy development for Stat5a/b-regulated cancers. Here, we sought to identify small molecule inhibitors of Stat5a/b for lead optimization and therapy development for prostate cancer and Bcr-Abl-driven leukemias. In silico screening of chemical structure databases combined with medicinal chemistry was used for identification of a panel of small molecule inhibitors to block SH2 domain-mediated docking of Stat5a/b to the receptor-kinase complex and subsequent phosphorylation and dimerization. We tested the efficacy of the lead compound IST5-002 in experimental models and patient samples of two known Stat5a/b-driven cancers, prostate cancer and chronic …

Triceps Tendon Ruptures Requiring Surgical Repair In National Football League Players., Joseph L Finstein, Steven B. Cohen, Christopher C Dodson, Michael G Ciccotti, Paul Marchetto, Matthew Pepe, Md, Peter F Deluca

Rothman Institute Papers

BACKGROUND: Complete triceps tendon ruptures are relatively rare in the general population but slightly more prevalent in professional football. One prior study found 11 complete ruptures over a 6-season period.

HYPOTHESIS: Triceps ruptures occur more commonly in football linemen due to forced elbow flexion during an eccentric contraction and may occur more commonly with the increasing size and speed of professional players. Surgical repair allows full return to sports, but with a lengthy recovery time.

STUDY DESIGN: Case series; Level of evidence, 4.

METHODS: A search of the National Football League Injury Surveillance System (NFLISS) found a total of 37 …

J-Wave Syndromes: Brugada And Early Repolarization Syndromes., Charles Antzelevitch, Gan-Xin Yan

Department of Medicine Faculty Papers

A prominent J wave is encountered in a number of life-threatening cardiac arrhythmia syndromes, including the Brugada syndrome and early repolarization syndromes. Brugada syndrome and early repolarization syndromes differ with respect to the magnitude and lead location of abnormal J waves and are thought to represent a continuous spectrum of phenotypic expression termed J-wave syndromes. Despite two decades of intensive research, risk stratification and the approach to therapy of these 2 inherited cardiac arrhythmia syndromes are still undergoing rapid evolution. Our objective in this review is to provide an integrated synopsis of the clinical characteristics, risk stratifiers, and molecular, ionic, …

Sex And Race And/Or Ethnicity Differences In Patients Undergoing Radiofrequency Ablation For Barrett's Esophagus: Results From The U.S. Rfa Registry., Sarina Pasricha, Nan Li, William J. Bulsiewicz, Richard I. Rothstein, Anthony Infantolino, Atilla Ertan, Daniel S. Camara, Evan S. Dellon, George Triadafilopoulos, Charles J. Lightdale, Ryan D. Madanick, William D. Lyday, Raman V. Muthusamy, Bergein F. Overholt, Nicholas J. Shaheen

Department of Medicine Faculty Papers

BACKGROUND: Little is known about differences in Barrett's esophagus (BE) characteristics by sex and race and/or ethnicity or these differences in response to radiofrequency ablation (RFA).

OBJECTIVE: We compared disease-specific characteristics, treatment efficacy, and safety outcomes by sex and race and/or ethnicity in patients treated with RFA for BE.

DESIGN: The U.S. RFA patient registry is a multicenter collaboration reporting processes and outcomes of care for patients treated with RFA for BE.

PATIENTS: Patients enrolled with BE.

INTERVENTIONS: RFA.

MAIN OUTCOME MEASUREMENTS: We assessed safety (stricture, bleeding, perforation, hospitalization), efficacy (complete eradication of intestinal metaplasia [CEIM]), complete eradication of dysplasia, …

Age At Onset In Patients With Medically Refractory Temporal Lobe Epilepsy And Mesial Temporal Sclerosis: Impact On Clinical Manifestations And Postsurgical Outcome., Ali Akbar Asadi-Pooya, Michael R. Sperling

Department of Neurology Faculty Papers

PURPOSE: To evaluate the demographic and clinical manifestations and postsurgical outcome of childhood-onset mesial temporal sclerosis and temporal lobe epilepsy (MTS-TLE) and establishing the potential differences as compared to the patients with adult-onset MTS-TLE.

METHOD: In this retrospective study all patients with a clinical diagnosis of medically refractory TLE due to mesial temporal sclerosis, who underwent epilepsy surgery at Jefferson comprehensive epilepsy center, were recruited. Patients were prospectively registered in a database from 1986 through 2014. Postsurgical outcome was classified into two groups; seizure-free or relapsed. Clinical manifestations and outcome were compared between patients with childhood-onset MTS-TLE (i.e., age at …

Mechanisms Of Immunological Tolerance In Central Nervous System Inflammatory Demyelination., Elisabeth R. Mari, Jason N. Moore, Guang-Xian Zhang, A. M. Rostami

Department of Neurology Faculty Papers

Multiple sclerosis is a complex autoimmune disease of the central nervous system that results in a disruption of the balance between pro-inflammatory and anti-inflammatory signals in the immune system. Given that central nervous system inflammation can be suppressed by various immunological tolerance mechanisms, immune tolerance has become a focus of research in the attempt to induce long-lasting immune suppression of pathogenic T cells. Mechanisms underlying this tolerance induction include induction of regulatory T cell populations, anergy and the induction of tolerogenic antigen-presenting cells. The intravenous administration of encephalitogenic peptides has been shown to suppress experimental autoimmune encephalomyelitis and induce tolerance …