Medicine and Health Sciences Commons^™

Metabolic Patterns In Cancer Cells And Tumor Micro-Environment In Diffuse Large B¬Cell Lymphoma: Tumor–Stromal Metabolic Coupling, Mahasweta Gooptu, Md, Alina E. Dulau Florea, Md, Benjamin E. Leiby, Phd, Barbara Pro, Md, John David Sprandio, Jr. Md, Diana Whitaker-Menezes, Phd, Paolo Cotzia, Md, Guldeep Uppal, Md, Jaime Caro, Md, Jerald Z. Gong, Md, Ubaldo E. Martinez-Outshoorn, Md

Department of Medical Oncology Posters

It has previously been suggested that the tumor microenvironment in diffuse large B-cell lymphoma (DLBCL) has prognostic significance. Furthermore, gene expression profiling in DLBCL patients has identified separate subsets with glycolytic and mitochondrial (oxidative phosphorylative) metabolic signatures.

Glycolytic metabolism forms the basis for FDG PET scans, widely used in staging and response assessment in DLBCL. While many assume that the tumor as a whole is primarily glycolytic, the metabolic patterns of cancer cells (C) and surrounding cancer-associated stromal cells (CAS) remain relatively unknown. We investigated the in situ metabolic patterns of C and CAS cells as well as tumor-associated macrophages …

Physician Executive Leadership: Student-Led Curriculum To Fill Gaps In Traditional Medical Education, Anuj Shah, Ronuk Modi, Jessica Downing, Angela Ugorets, Kathryn Linder, Michael Jacobs, Graham Hale, Jeffrey Fitch, Nicholas Kurtzman, Paul Rosen, Md

Physician Executive Leadership

Students at Sidney Kimmel Medical College (SKMC) have identified a gap in the traditional medical curriculum surrounding topics such as telehealth, the patient experience, health policy, medical malpractice, and health care entrepreneurship and innovation, and in response have initiated a student-centered, student-led, student-driven program called Physician Executive Leadership (PEL). PEL provides students with a variety of avenues to engage with these topics, such as lectures from leaders in each of these fields, easy access to weekly news articles on current events in health care, targeted review sessions on the US health care system, and the opportunity to voice and develop …

Functional Integrity Of Resting-State Networks Predicts Seizure Outcome After Anterior Temporal Lobectomy, Gaelle Doucet, Xiaosong He, Michael R. Sperling, Ashwini Sharan Md, Joseph I. Tracy

Department of Neurosurgery Posters

Rationale

Predicting seizure outcome (SO) after anterior temporal lobectomy (ATL) is a major clinical goal. With clear evidence that even focal epilepsies disrupt large scale brain networks, resting-state functional connectivity (FC) methods have been increasingly used on a pre-surgical basis to characterize the impact of seizures on brain activity. In this project, we sought to determine whether the functional integrity of resting-state networks (RSNs) prior to surgery can discriminate between patients who obtain good versus poor seizure control after ATL.

Daptomycin Non-Susceptible Mrsa Bacteremia: A Case Report, Jaclyn Cusumano, Pharmd, Anna Marie Morlino, Pharmd, Andrew Moyer, Pharmd

College of Pharmacy Posters

Background

Staphylococcus aureus^{1, 2, 3}

• One of the most common pathogens causing community-acquired and nosocomial infections
• Has rapidly developed resistance to many antibiotics:

Daptomycin ²

• Bactericidal cyclic lipopeptide antibiotic
• Possesses negative charge which attracts calcium to form cationic complex
• Interacts with negatively charged phospholipid heads on bacterial cell membranes, leading to membrane depolarization and cell death

Daptomycin non-susceptible (DNS) S. aureus ^{2, 4, 5}

• Extremely rare - About 60 clinical cases reported
• Defined by an MIC greater than 1 mcg/mL
• Potential mechanisms include:

– Changes in cell membrane and cell wall structure alter daptomycin’s permeability²

• Overexpression and dysregulation …

Mary Woltemate Stec, Mary Woltemate Stec, Kelsey Duinkerken

Jefferson Nursing Oral Histories

Dr. Stec began her nursing career in 1973 as a graduate of Jefferson’s Nursing Diploma School. She would go on to receive her BS in Nursing from the University of Pennsylvania, her MSN from Gwynedd Mercy College, and her PhD in Nursing from Widener University. Dr. Stec has spent the majority of her career as a nursing educator, including as an instructor at Thomas Jefferson University Hospital School of Nursing, Gwynedd Mercy College, and Abington Memorial Hospital Dixon School of Nursing. She is now an Assistant Professor at Temple University. She is also a Certified Nurse Educator, an Evaluator for …

Bepress Notes Jdc Feedback Feature, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

In October we posted What People are Saying About the JDC to highlight the new Jefferson Digital Commons feedback feature (how to submit it and how to view what others have said).

Katherine Kingsley Kinsey, Katherine Kingsley Kinsey, Kelsey Duinkerken

Jefferson Nursing Oral Histories

Dr. Kinsey received her nursing diploma from the Jefferson Hospital School of Nursing in 1963 and later a BS in Education and School Health from Millersville University. She also has a BS in Nursing, Magna Cum Laude, a MS in Nursing in Community Health, and a PhD in Education, all from the University of Pennsylvania. She currently serves as the Nurse Administrator and Principal Investigator for the Philadelphia Nurse-Family Partnership (NFP), the Mabel Morris Family Home Visit Program (MM), and other early childhood initiatives. Previously, Dr. Kinsey was a tenured professor at La Salle University School of Nursing where she …

Dr. John H. Gibbon, Jr. And Jefferson's Heart-Lung Machine: Commemoration Of The World's First Successful Bypass Surgery, F. Michael Angelo

Posters: Jefferson History

On May 6, 1953 at Jefferson Medical College Hospital, Dr. John Heysham Gibbon, Jr., his staff, and with the help of his latest-designed heart-lung machine, “Model II,” closed a very serious septal defect between the upper chambers of the heart of eighteen-year-old Cecelia Bavolek. This was the first successful intercardiac surgery of its kind performed on a human patient. Ms. Bavolek was connected to the device for three-quarters of an hour and for 26 crucial minutes, the patient totally depended upon the machine’s artificial cardiac and respiratory functions. “Jack” Gibbon did not follow this epoch-making event by holding an international …

African American Graduates Of Jefferson Medical College: The First Hundred Years, F. Michael Angelo

Posters: Jefferson History

Beginnings…

The story of early African American physicians begins in 18th century Philadelphia with James Derham who is recognized as the first black allopathic (regular, non-sectarian) medical doctor. The first medical school in the U.S. to admit an African American was Rush Medical College in Chicago that awarded, in 1847, David J. Peck his degree. Dr. Peck came to the “Quaker City” to set up his practice the same year that the A.M.A. was formed, also here in Philadelphia. In 1877, Jefferson doctors protested the seating of the delegates from Howard University, the nation’s most important black medical school, in …

Latin Heritage Month. Carlos Juan Finlay: Outrageous, Courageous And Correct, Dorothy E. Berenbrok

Posters: Jefferson History

In 1855, a modest Cuban physician named Carlos Juan Finlay graduated from Jefferson Medical College. He was among JMC’s first dozen Hispanic graduates, initially signing the registrar’s log as “Charles”. He left Philadelphia at the age of 22 to begin private practice. Preceptor and close friend S. Weir Mitchell, among others, urged Finlay to work among the burgeoning Spanishspeaking population in New York City, but he returned to Cuba and set up practice in Matanzas, a town near Havana. He took a binocular microscope with him, similar to one used byMitchell, which would serve him well for many years.

During …

United States Medicine, Women And Jefferson Medical College, F. Michael Angelo

Posters: Jefferson History

Timeline of women at Jefferson Medical College.

A Delphi Method Analysis To Create An Emergency Medicine Educational Patient Satisfaction Survey., Kory S London, Bonita Singal, Jennifer Fowler, Rebecca Prepejchal, Stefanie Simmons, Douglas Finefrock

Department of Emergency Medicine Faculty Papers

INTRODUCTION: Feedback on patient satisfaction (PS) as a means to monitor and improve performance in patient communication is lacking in residency training. A physician's promotion, compensation and job satisfaction may be impacted by his individual PS scores, once he is in practice. Many communication and satisfaction surveys exist but none focus on the emergency department setting for educational purposes. The goal of this project was to create an emergency medicine-based educational PS survey with strong evidence for content validity.

METHODS: We used the Delphi Method (DM) to obtain expert opinion via an iterative process of surveying. Questions were mined from …

Low-Dose Versus Standard-Dose Tissue Plasminogen Activator In Acute Ischemic Stroke In Asian Populations: A Meta-Analysis., Meng-Dong Liu, Wei-Dong Ning, Ren-Cong Wang, Wei Chen, Yang Yang, Yan Lin, Da-Hai Hu, Wayne Bond Lau, Yan Qu

Department of Emergency Medicine Faculty Papers

Recent studies have investigated the most efficacious dose of intravenous tissue plasminogen activator (IV-tPA) for acute ischemic stroke (AIS) patients. There remains no definitive consensus concerning the superior efficacious IV-tPA dose (standard- vs. low-dose), prompting us to perform a meta-analysis comparing the efficacy and safety profile of standard- versus low-dose IV-tPA.We identified relevant studies pertaining to the specific aim of our meta-analysis by searching PubMed and EMBASE (January 1990-September 2015) Either a fixed- or random-effects model was employed (dependent upon data heterogeneity) to analyze the efficacy and safety outcome.Ten cohort studies involving 4389 sum patients were included in the meta-analysis. …

A Synthetic Lethality Screen Using A Focused Sirna Library To Identify Sensitizers To Dasatinib Therapy For The Treatment Of Epithelial Ovarian Cancer., Harsh B Pathak, Yan Zhou, Geetika Sethi, Jeff Hirst, Russell J Schilder, Erica A Golemis, Andrew K Godwin

Department of Medicine Faculty Papers

Molecular targeted therapies have been the focus of recent clinical trials for the treatment of patients with recurrent epithelial ovarian cancer (EOC). The majority have not fared well as monotherapies for improving survival of these patients. Poor bioavailability, lack of predictive biomarkers, and the presence of multiple survival pathways can all diminish the success of a targeted agent. Dasatinib is a tyrosine kinase inhibitor of the Src-family kinases (SFK) and in preclinical studies shown to have substantial activity in EOC. However, when evaluated in a phase 2 clinical trial for patients with recurrent or persistent EOC, it was found to …

Intraventricular Sialidase Administration Enhances Gm1 Ganglioside Expression And Is Partially Neuroprotective In A Mouse Model Of Parkinson's Disease., Jay S Schneider, Thomas N Seyfried, Hyo-S Choi, Sarah Kidd

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Preclinical and clinical studies have previously shown that systemic administration of GM1 ganglioside has neuroprotective and neurorestorative properties in Parkinson's disease (PD) models and in PD patients. However, the clinical development of GM1 for PD has been hampered by its animal origin (GM1 used in previous studies was extracted from bovine brains), limited bioavailability, and limited blood brain barrier penetrance following systemic administration.

OBJECTIVE: To assess an alternative therapeutic approach to systemic administration of brain-derived GM1 to enhance GM1 levels in the brain via enzymatic conversion of polysialogangliosides into GM1 and to assess the neuroprotective potential of this approach. …

Non-Specific Blocking Of Mir-17-5p Guide Strand In Triple Negative Breast Cancer Cells By Amplifying Passenger Strand Activity., Yuan-Yuan Jin, Jade Andrade, Eric Wickstrom

Department of Biochemistry and Molecular Biology Faculty Papers

Conventional wisdom holds that only one of the two strands in a micro ribonucleic acid (miRNA) precursor duplex is selected as the active miRNA guide strand. The complementary miRNA passenger strand, however, is thought to be inactive. High levels of the oncogenic miRNA (oncomiR) guide strand called miR-17-5p is overexpressed in triple negative breast cancer (TNBC) and can inhibit ribosomal translation of tumor suppressor gene mRNAs, such as programmed cell death 4 (PDCD4) or phosphatase and tensin homolog (PTEN). We hypothesized that knocking down the oncogenic microRNA (oncomiR) miR-17-5p might restore the expression levels of PDCD4 and PTEN tumor suppressor …

Prevalence And Antimicrobial Susceptibility Pattern Of Coagulase-Negative Staphylococci (Cons) Isolated From Clinical Specimens In Northern Of Jordan, Ibrahim Ali Al Tayyar, Mazhar Salim Al-Zoubi, Emad Hussein, Salih Khudairat, Konrad Sarosiek

Department of Surgery Faculty Papers

No abstract provided.

Patricia Maro Dehart, Patricia Maro Dehart, Kelsey Duinkerken

Jefferson Nursing Oral Histories

Patricia Maro DeHart first became interested in nursing in high school when she first volunteered, and later worked, as a nurses’ aide in a local nursing home. She decided to attend Jefferson’s Diploma Nursing program and graduated in 1977. After starting her career in medical surgery at West Jersey Hospital she then worked as an OB-GYN nurse at Thomas Jefferson University Hospital for eleven years. As her career progressed she moved to Bristol-Myers Squibb, where she held a number of varied positions that allowed her to combine both her degrees in nursing and business, including as account executive and government …

New College Within The College Posters, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

College within the College(CwiC) is a four year academic area of concentration designed to enrich the Medical College curriculum for those students who seek additional training in Population Health. This program aims to step beyond the individual-level focus of mainstream medicine by addressing a broad range of factors that impact health, such as: environment, literacy, ethnicity, social structure, resource distribution, health systems, and health education/promotion. This collection consists of posters and presentations developed by Jefferson CwiC-PH medical students in their exploration of service, research/evaluation, and policy analysis in local, regional, and international settings.

Detection Of Sleep Disordered Breathing In Patients Hospitalized With Congestive Heart Failure, Sunil Sharma, Paul Mather

Department of Sleep Medicine Faculty Papers

OBJECTIVES: The purpose of this study was to evaluate the plethysmographic signal-derived oxygen desaturation index (ODI) as an inpatient screening strategy to identify sleep-disordered breathing (SDB) in patients with congestive heart failure (CHF).

BACKGROUND: SDB is highly prevalent among patients hospitalized with CHF but is widely underdiagnosed. We evaluated overnight photoplethysmography as a possible screening strategy for hospitalized patients with CHF.

METHODS: Consecutively admitted heart failure patients with high clinical suspicion of SDB and ODI ≥5 were offered outpatient polysomnography (PSG), which was completed within 4 weeks of discharge. PSG was considered positive if the apnea hypoxia index (AHI) was …

Antibiotic Resistance And The White House Forum On Antibiotic Stewardship, Mary Lou Manning Phd, Crnp, Cic, Faan

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Pharmacists On The Front Lines Of Polypharmacy: The Individualized Medication Assessment And Planning (Imap) Project To Improve Medication Use In Senior Adults With Cancer, Ginah Nightingale Pharmd, Bcop, Laura T. Pizzi Pharmd, Mph, Emily Hajjar Pharmd, Bcps, Bcacp, Cgp, Elizabeth Pigott, Margaret Wang, Shannon Doherty, Kristine Swartz Md, Andrew Chapman Do, Facp

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Jefferson Interprofessional Education Center Teamstepps Workshops For Staff, Alan Forstater Md, Facep, Dimitri Papanagnou Md, Mph, Kevin Lyons Phd, Shoshana Sicks Med, Elizabeth Speakman Edd, Rn, Cde, Anef

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Smoking It Out; Vaping Is In. The Rise Of E-Cigarettes Amoung U.S. Youth, Russell K. Mcintire Phd, Mph, Brianna Ludwig

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Care With Dignity: A Patient-Centered Focus For Treatment Of Vulnerable Populations, Marlee Madora, Molly Klores

CwiC Posters

Summary:

Philadelphia FIGHT is a comprehensive HIV/AIDS service organization providing primary care, consumer education, advocacy, and research on potential treatments and vaccines. FIGHT was formed as a partnership of individuals living with HIV/ AIDS and clinicians, who joined together to improve the lives of people living with the disease. Today, FIGHT serves an even broader patient population and recently received designation as a Federally Qualified Health Center. FIGHT strives to address not only HIV-infected patients, but all at-risk populations through education, outreach, and preventative medicine.

The annual Bridging the Gaps interns are responsible for several projects, including a client satisfaction …

Thomas Jefferson University's Reader Survey Captures Ir's Value, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

Dan Kipnis, Education Services Librarian at Thomas Jefferson University, has come up with an ingenious way to capture hard-to-find reader feedback on publications in their IR, The Jefferson Digital Commons. Dan explains that the results “will be used in quarterly reports and for demonstrating value to administrators and the entire community at Thomas Jefferson University.”

Confirmatory Factor Analysis And Invariance Testing Between Blacks And Whites Of The Multidimensional Health Locus Of Control Scale., Marianna Lanoue, Abby Harvey, Dawn B. Mautner, Bon Ku, Kevin Scott

Department of Family & Community Medicine Faculty Papers

The factor structure of the Multidimensional Health Locus of Control scale remains in question. Additionally, research on health belief differences between Black and White respondents suggests that the Multidimensional Health Locus of Control scale may not be invariant. We reviewed the literature regarding the latent variable structure of the Multidimensional Health Locus of Control scale, used confirmatory factor analysis to confirm the three-factor structure of the Multidimensional Health Locus of Control, and analyzed between-group differences in the Multidimensional Health Locus of Control structure and means across Black and White respondents. Our results indicate differences in means and structure, indicating more …

Fibronectin Signals Through Integrin Α5Β1 To Regulate Cardiovascular Development In A Cell Type-Specific Manner., Dongying Chen, Xia Wang, Dong Liang, Julie Gordon, Ashok Mittal, Nancy Manley, Karl Degenhardt, Sophie Astrof

Department of Medicine Faculty Papers

Fibronectin (Fn1) is an evolutionarily conserved extracellular matrix glycoprotein essential for embryonic development. Global deletion of Fn1 leads to mid-gestation lethality from cardiovascular defects. However, severe morphogenetic defects that occur early in embryogenesis in these embryos precluded assigning a direct role for Fn1 in cardiovascular development. We noticed that Fn1 is expressed in strikingly non-uniform patterns during mouse embryogenesis, and that its expression is particularly enriched in the pharyngeal region corresponding with the pharyngeal arches 3, 4, and 6. This region bears a special importance for the developing cardiovascular system, and we hypothesized that the localized enrichment of Fn1 in …

Emerging Immunopharmacological Targets In Multiple Sclerosis., Mojtaba Farjam, Guang-Xian Zhang, Bogoljub Ciric, Abdolmohamad Rostami

Department of Neurology Faculty Papers

Inflammatory demyelination of the central nervous system (CNS) is the hallmark of multiple sclerosis (MS), a chronic debilitating disease that affects more than 2.5 million individuals worldwide. It has been widely accepted, although not proven, that the major pathogenic mechanism of MS involves myelin-reactive T cell activation in the periphery and migration into the CNS, which subsequently triggers an inflammatory cascade that leads to demyelination and axonal damage. Virtually all MS medications now in use target the immune system and prevent tissue damage by modulating neuroinflammatory processes. Although current therapies such as commonly prescribed disease-modifying medications decrease the relapse rate …

Road To Recovery: Dysphagia Treatment With An Adult With Sma Type Ii, Kara Maharay, M.S., Ccc-Slp, Bcs-S, Kelly Salmon, M.A., Ccc-Slp, Bcs-S, Clt-Lana, Ronald S. Kaiser, Ph.D

Department of Rehabilitation Medicine Posters

Objective: Spinal Muscular Atrophy (SMA) is a genetic and degenerative motor neuron disease that affects muscle control including the muscles responsible for head and neck control and swallowing (Kesting, n. d.). There is limited research on the benefits of exercise as a therapeutic modality for people with Spinal Muscular Atrophy (SMA) (Swoboda et al., 2007) and no existing research specifically targeting pharyngeal or laryngeal strengthening to improve swallow function. As demonstrated by the positive outcome in this case study, speech-language pathologists should be aware that various modalities for dysphagia treatment such as biofeedback, neuromuscular electrical stimulation (NMES), and an exercise …