Medicine and Health Sciences Commons^™

Microrna Dysregulation And Esophageal Cancer Development Depend On The Extent Of Zinc Dietary Deficiency., Louise Fong, Cristian Taccioli, Ruiyan Jing, Karl Smalley, Hansjuerg Alder, Yubao Jiang, Paolo Fadda, John Farber, Carlo M Croce

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Zinc deficiency (ZD) increases the risk of esophageal squamous cell carcinoma (ESCC), and marginal ZD is prevalent in humans. In rats, marked-ZD (3 mg Zn/kg diet) induces a proliferative esophagus with a 5-microRNA signature (miR-31, -223, -21, -146b, -146a) and promotes ESCC. Here we report that moderate and mild-ZD (6 and 12 mg Zn/kg diet) also induced esophageal hyperplasia, albeit less pronounced than induced by marked-ZD, with a 2-microRNA signature (miR-31, -146a). On exposure to an environmental carcinogen, ~16% of moderate/mild-ZD rats developed ESCC, a cancer incidence significantly greater than for Zn-sufficient rats (0%) (P ≤ 0.05), but lower than …

Acute Rehabilitation Of Spinal Epidural Abscess Following Triple Laminectomy: A Case Report, B. A. Dahlben, Ms, D. Fleischmann, Md

Department of Rehabilitation Medicine Posters

Case Description:

• A 36-year-old man presented with a large epidural collection, shown on MRI to extend from C1-S5 and resulting in spinal canal narrowing (Figures 1-3). The patient was admitted for acute inpatient rehabilitation after neurosurgical treatment and stabilization s/p C7-T1, T7-8, L4-5 laminectomies.
• He presented with impaired mobility and activities of daily living, and reported moderate pain in the back and lower extremities, but without specific distribution, during PT/OT therapies.
• Throughout his 7-day length of stay, the patient was closely monitored for methicillin-susceptible S. aureus bacteremia, and he received IV oxacillin and oral rifampin. Active medical problems …

Design Of Barrier Coatings On Kink-Resistant Peripheral Nerve Conduits., Basak Acan Clements, Jared Bushman, N. Sanjeeva Murthy, Mindy Ezra, Christopher M. Pastore, Joachim Kohn

Kanbar College Faculty Papers

Here, we report on the design of braided peripheral nerve conduits with barrier coatings. Braiding of extruded polymer fibers generates nerve conduits with excellent mechanical properties, high flexibility, and significant kink-resistance. However, braiding also results in variable levels of porosity in the conduit wall, which can lead to the infiltration of fibrous tissue into the interior of the conduit. This problem can be controlled by the application of secondary barrier coatings. Using a critical size defect in a rat sciatic nerve model, the importance of controlling the porosity of the nerve conduit walls was explored. Braided conduits without barrier coatings …

Conjugate Haemophilus Influenzae Type B Vaccines For Sickle Cell Disease., Slimane Allali, Martin Chalumeau, Odile Launay, Samir K. Ballas, Mariane De Montalembert

Cardeza Foundation for Hematologic Research

BACKGROUND: People affected with sickle cell disease are at high risk of infection from Haemophilus influenzae type b. Before the implementation of Haemophilus influenzae type b conjugate vaccination in high-income countries, this was responsible for a high mortality rate in children under five years of age. In African countries, where coverage of this vaccination is still extremely low, Haemophilus influenzae type b remains one of the most common cause of bacteraemias in children with sickle cell disease. The increased uptake of this conjugate vaccination may substantially improve the survival of children with sickle cell disease.

OBJECTIVES: The primary objective was …

Does Yoga Practice Improve Balance In Older Adults?, Joanna Alfieri, Spt, Andrea Barberio, Spt, Ryt-500, Rebecca Mccammitt, Spt, Kevin Reeder, Spt, Susan Duff, Pt, Edd, Cht, Ryt-200

Department of Physical Therapy Capstone Posters

Purpose and Hypothesis:

The purpose of this systematic review was to determine the effects of a regular yoga program on balance in older adults. We hypothesized that a regular yoga program would improve balance and consequently reduce fall risk in the older adult population.

The Relationship Between Body Positioning, Muscle Activity, And Spinal Kinematics In Cyclists With And Without Low Back Pain, Gabriel Streisfeld, Spt, Caitlin E. Bartoszek, Spt, Emily F. Creran, Spt, Brianna A. Inge, Spt, Marc D. Mcshane, Spt, Therese E. Johnston, Pt, Phd, Mba

Department of Physical Therapy Capstone Posters

Objectives:

• To determine if relationships exist between body positioning, spinal kinematics, and muscle activity in active cyclists with non-traumatic LBP.
• To explore variations in optimal positioning and bike set up in order to address variables associated with LBP in the physical therapy clinic.

Locomotor Training In The Pediatric Spinal Cord Injury Population: A Systematic Review Of The Literature, Katelin Gorski, Spt, Kelsey Harbold, Spt, Katelyn Haverstick, Spt, Emily Schultz, Spt, Stephanie E. Shealy, Ms, Spt, Laura Krisa, Phd

Department of Physical Therapy Capstone Posters

Purpose:

The aim of this review was to investigate the effects of locomotor training on pediatric SCI and develop recommendations for pediatric LT guidelines.

Lois Whaley Highsmith, Lois Whaley Highsmith, Kelsey Duinkerken

Jefferson Nursing Oral Histories

After originally studying chemical engineering at Penn State, Lois Highsmith decided to instead pursue nursing. At Jefferson she found a passion for community health nursing, specifically related to obstetrics, gynecology, and maternal child health. Ms. Highsmith graduated in 1986 and over the years worked mostly in maternal care but also in psychology. Among other positions, she worked for ten years at Pennsylvania Hospital where she founded STEPS, Strategies to Encourage Parental Self-Sufficiency, a teen pregnancy clinic, and worked as a home visitor for Mercy Home Health educating new moms about postpartum care. Since 2002 she has worked for Nurse Family …

Effects Of High Intensity Exercise On Central Neural Drive In Healthy Populations, Nicholas Legrand, Spt, Kyra Robb, Spt, Emily Slobodian, Spt, Nicole Weaknecht, Spt, Megan Wood, Spt, Stephanie Muth, Pt, Phd

Department of Physical Therapy Capstone Posters

Background:

Current research suggests that strength gains related to central neural adaptation occur more rapidly than peripheral mechanisms5. Central neural drive (CND) is the measure of cortical output that coordinates up-regulation of agonist contraction and inhibition of antagonist musculature in voluntary muscle contractions2. Two common techniques for measuring CND are twitch interpolation and motor evoked potential from transcranial magnetic stimulation.

Biomechanical Factors Associated With Knee Pain In Cyclists: A Systematic Review Of The Literature, Tiara Baskins, Spt, Rachael Koppel, Spt, Sam Oliver, Spt, Dj Stieber, Spt, Therese E. Johnston, Pt, Phd, Mba

Department of Physical Therapy Capstone Posters

Purpose:

This systematic review will focus on literature related to positioning on, and configuration of the bicycle that can influence forces acting on the knee and their potential effects on injury. This review also serves to present recommendations for rehabilitation and injury prevention based on the findings in current literature. The goal of this research was to develop an algorithm that can be used in guiding decision making for the sports medicine practitioner.

High Intensity Interval Training In High Risk Individuals: A Systematic Review Of The Literature, Claire Marine, Spt, Stephanie Nagy, Spt, Chelsea Payne, Spt, Carolyn Wise, Spt, Christine K. Wade, Pt, Edd, Rn

Department of Physical Therapy Capstone Posters

Purpose: This systematic review of the literature (SRL) aims to demonstrate that high intensity interval training is an effective, safe, and more efficient training protocol as compared to continuous moderate intensity exercise in patients with COPD or HF

The Effect Of Night Splints In The Treatment Of Plantar Fasciitis: A Systematic Literature Review, Kelly Boatwright, Spt, Thomas Hutchinson, Spt, Alyssa Saurman, Spt, Ernesto Méndez, Spt, Christopher Wanyo, Spt, Paul Howard, Pt, Dpt, Phd, Ocs, Faaompt

Department of Physical Therapy Capstone Posters

Objective:

To investigate the use of night splints for the treatment of plantar fasciitis and the current evidence regarding their ability to affect symptoms associated with plantar fasciitis.

Self-Selected Foot Strike Patterns In Runners When Transitioning From The Shod To Barefoot Condition: A Systematic Review Of The Literature, Jarett Fisher, Spt, Thomas Fraind, Spt, David A. Girardot, Spt, Erin James, Spt, Mary Mccoy, Spt, Carl Pitts, Pt, Dpt

Department of Physical Therapy Capstone Posters

Purpose and Background:

Recent research has begun to focus on foot strike patterns as they relate to injuries in runners. Runners who employ a rear-foot strike (RFS) pattern (in which the heel lands before the ball of the foot) are more likely to experience repetitive stress injuries such as tibial stress fractures, patellofemoral pain syndrome (PFPS), and plantar fasciitis. Conversely, runners demonstrating a forefoot strike (FFS) pattern (defined as the ball of the foot-usually the 4th and 5th metatarsal heads-landing before the heel) are more susceptible to Achilles tendon, plantarflexor, and metatarsal injuries. Several systematic studies have concluded that barefoot …

The Most Effective And Efficient Bedside Exam For The Dizzy Patient In The Acute Care Setting: A Systematic Review Of The Literature, Alexandra Davis, Spt, Katierae Hunsicker, Spt, Cathy Lee, Spt, Megan Shultz, Spt, Janette Scardillo, Pt, Dpt, Cbis

Department of Physical Therapy Capstone Posters

Purpose:

The purpose of this systematic review of the literature (SRL) is to evaluate the effectiveness and efficiency of vestibular bedside tests for patients with complaints of dizziness and vertigo in the acute care setting. This includes differentiating between a central and peripheral disorder, as well as diagnosing peripheral disorders within the scope of physical therapy practice

Does High-Intensity Exercise Better Improve Ambulation In The Population With Chronic Stroke, As Compared To Standard Care?: A Systematic Review Of The Literature, Caitlin Caruso, Spt, Courtney Comstock, Spt, Ashley Mckenna, Spt, Samantha Nixon, Spt, Ashley Wonneberger, Spt, Christine M. Tyrell, Pt, Phd, Ncs

Department of Physical Therapy Capstone Posters

Purpose:

To assess the effectiveness of high-intensity exercise on the improvement of gait deficits in survivors of chronic stroke as compared to standard care.

Application Of Dual Task Performance In Pediatrics And Adults With Traumatic Brain Injury: A Systematic Review, Lauren Bilski, Kathleen Clancy, Victoria Dean, Danielle Melfi, Kristin Reardon, Louis N. Hunter, Pt, Dpt

Department of Physical Therapy Capstone Posters

Purpose:

The aim of this systematic review of the literature is to investigate the application of cognitive and motor dual task paradigms in the physical therapy management of moderate to severe TBI population across the lifespan in physical therapy practice.

Corticosteroid Implants For Chronic Non-Infectious Uveitis., Christopher J Brady, Andrea C Villanti, Hua Andrew Law, Ehsan Rahimy, Rahul Reddy, Pamela C. Sieving, Sunir J. Garg, Johnny Tang

Wills Eye Hospital Papers

BACKGROUND: Uveitis is a term used to describe a heterogeneous group of intraocular inflammatory diseases of the anterior, intermediate, and posterior uveal tract (iris, ciliary body, choroid). Uveitis is the fifth most common cause of vision loss in high-income countries, accounting for 5% to 20% of legal blindness, with the highest incidence of disease in the working-age population.Corticosteroids are the mainstay of acute treatment for all anatomical subtypes of non-infectious uveitis and can be administered orally, topically with drops or ointments, by periocular (around the eye) or intravitreal (inside the eye) injection, or by surgical implantation.

OBJECTIVES: To determine the …

Vera Paoletti, Vera Paoletti, Kelsey Duinkerken

Jefferson Nursing Oral Histories

Vera Paoletti became interested in nursing as a teenager after watching a close family member succumb to leukemia. This experience led her to work as a candy striper at Jefferson Hospital through her high school years and then enroll in the Jefferson Hospital School of Nursing in 1966. Once she graduated in 1969 Ms. Paoletti began her career as a nurse at Jefferson, first in surgery on Ninth Pavilion and then in oncology on Eleventh Pavilion before becoming head nurse first of a nineteen-bed unit reserved for VIPs and then two years later of Sixth Main. In 1975 she left …

Plan Quality And Treatment Efficiency For Radiosurgery To Multiple Brain Metastases: Non-Coplanar Rapidarc Vs. Gamma Knife., Haisong Lui Phd, David W. Andrews Md, James J. Evans, Maria Werner-Wasik, Yan Yu, Adam Dicker Md, Phd, Wenyin Shi

Department of Radiation Oncology Faculty Papers

OBJECTIVES: This study compares the dosimetry and efficiency of two modern radiosurgery [stereotactic radiosurgery (SRS)] modalities for multiple brain metastases [Gamma Knife (GK) and LINAC-based RapidArc/volumetric modulated arc therapy], with a special focus on the comparison of low-dose spread.

METHODS: Six patients with three or four small brain metastases were used in this study. The size of targets varied from 0.1 to 10.5 cc. SRS doses were prescribed according to the size of lesions. SRS plans were made using both Gamma Knife(®) Perfexion and a single-isocenter, multiple non-coplanar RapidArc(®). Dosimetric parameters analyzed included RTOG conformity index (CI), gradient index (GI), …

Mesial Temporal Lobe Epilepsy With Childhood Febrile Seizure., Ali Akbar Asadi-Pooya, Maromi Nei, Cyrus Rostami, Michael R. Sperling

Department of Neurology Faculty Papers

OBJECTIVES: To evaluate the demographic and clinical manifestations of patients with mesial temporal sclerosis and temporal lobe epilepsy (MTS-TLE) with childhood febrile seizure (FS) and establishing the potential differences as compared to those without FS. We also investigated the surgery outcome in these two groups of patients.

MATERIALS AND METHODS: In this retrospective study, all patients with a clinical diagnosis of drug-resistant TLE due to mesial temporal sclerosis, who underwent epilepsy surgery at Jefferson Comprehensive Epilepsy Center, were recruited. Patients were prospectively registered in a database from 1986 through 2014. Postsurgical outcome was classified into two groups; seizure-free or relapsed. …

Dual Kidney Allocation Score: A Novel Algorithm Utilizing Expanded Donor Criteria For The Allocation Of Dual Kidneys In Adults, Adam P. Johnson, Md, Mph, Thea P. Price, Md, Benjamin E Leiby, Phd, Cataldo Doria, Md, Phd, Facs

Department of Surgery Posters

Background:

Dual kidney transplantation (DKT) of expanded criteria donors is a cost intensive procedure to help increase the pool of available deceased organ donors. In studies to day, expanded criteria single kidney (eSKT) or dual kidney transplantation (DKT) have demonstrated equivalence, but a more rigorous allocation system is needed to optimize limited resources for improved operative outcomes.

Joan Walker Randolph, Joan Walker Randolph, Kelsey Duinkerken

Jefferson Nursing Oral Histories

Joan Randolph is a 1956 graduate of the Jefferson School of Nursing’s Diploma Program. Though she enjoyed all of her nursing rotations as a student, upon graduation she decided to go into medical-surgical nursing, starting her career at Jefferson Hospital working with, among others, Dr. John Gibbon. After leaving Jefferson, Ms. Randolph spent the bulk of her career at Jeanes Hospital, where she worked her way up from staff nurse to head nurse and eventually on to Vice President of Patient Care Services. Though now retired Ms. Randolph continues to be involved with the field of nursing by serving on …

Consecutive Bilateral Decompression Retinopathy After Mitomycin C Trabeculectomy: A Case Report., Ana Raquel Marcos Figueiredo, Isabel Coutinho Sampaio, Maria João Fernandes Dos Santos Menéres, George L. Spaeth

Wills Eye Hospital Papers

BACKGROUND: After a successful trabeculectomy, a sudden intraocular pressure decrease may alter the intracranial to intraocular pressure ratio and cause decompression retinopathy. Frequent Valsalva maneuvers may also play a role in its pathogenesis. This condition may manifest as multiple retinal hemorrhages, edema of the optic disc, macular edema, or a sudden decrease in visual acuity postoperatively. Outcomes for patients are usually good, with spontaneous resolution occurring within a matter of weeks. It has been rarely reported in the literature as a bilateral condition.

CASE PRESENTATION: We present a case of consecutive bilateral decompression retinopathy in a 54-year-old severely obese Caucasian …

Lambda Red-Mediated Recombineering In The Attaching And Effacing Pathogen Escherichia Albertii., Marisa Egan, Jasmine Ramirez, Christian Xander, Chirag Upreti, Shantanu Bhatt

Department of Medicine Faculty Papers

BACKGROUND: The ability to introduce site-specific mutations in bacterial pathogens is essential towards understanding their molecular mechanisms of pathogenicity. This has been greatly facilitated by the genetic engineering technique of recombineering. In recombineering, linear double- or single-stranded DNA molecules with two terminal homology arms are electroporated into hyperrecombinogenic bacteria that express a phage-encoded recombinase. The recombinase catalyzes the replacement of the endogenous allele with the exogenous allele to generate selectable or screenable recombinants. In particular, lambda red recombinase has been instrumental in engineering mutations to characterize the virulence arsenal of the attaching and effacing (A/E) pathogens enteropathogenic Escherichia coli (EPEC), …

Colleen Young Elwood, Colleen Young Elwood, Kelsey Duinkerken

Jefferson Nursing Oral Histories

Colleen Young Elwood discovered her interest in nursing after finishing a Bachelor’s of Science in psychology and starting her career at Juvenile Diabetes Research Foundation. Learning about diabetes and working with diabetics sparked an interest in public and community health so she enrolled in Thomas Jefferson University’s two-year BSN program, which she graduated from in 2013. While at Jefferson her clinical experiences confirmed she was not interested in hospital nursing but instead in community nursing. After graduating she started working at Nurse Family Partnership, first as an intern and then as a Nurse-Home Visitor, where she helps new mothers during …

Spatially Selective 2d Rf Inner Field Of View (Ifov) Diffusion Kurtosis Imaging (Dki) Of The Pediatric Spinal Cord, Chris J. Conklin, Devon M. Middleton, Mehdi Alizadeh, Jürgen Finsterbusch, David L. Raunig, Scott H. Faro, Pallav N. Shah, Laura Krisa, Rebecca Sinko, Ms, Otr/L, Joan Z. Delalic, M. J. Mulcahey, Feroze B. Mohamed

Department of Physical Therapy Faculty Papers

No abstract provided.

Variables Prognostic For Delayed Union And Nonunion Following Ulnar Shortening Fixed With A Dedicated Osteotomy Plate., Michael P. Gaspar, Patrick M. Kane, Ralph C Zohn, Taylor Buckley, Sidney M. Jacoby, Eon K. Shin

Department of Orthopaedic Surgery Faculty Papers

PURPOSE: To examine potential risk factors for the development of delayed or nonunion following elective ulnar shortening osteotomy using a dedicated osteotomy plating system.

METHODS: We performed a retrospective review of all patients who underwent elective ulnar shortening using the TriMed single osteotomy dynamic compression plating system by 1 of 2 fellowship-trained hand surgeons over a 5-year period. Demographic data and medical, surgical, and social histories were reviewed. Time to bony union was determined radiographically by a blinded reviewer. Bivariate statistical analysis was performed to examine the effect of explanatory variables on the time to union and the incidence of …

Optimal Unified Combination Rule In Application Of Dempster-Shafer Theory To Lung Cancer Radiotherapy Dose Response Outcome Analysis, Yanyan He, M. Yousuff Hussaini, Yutao U T Gong, Ying Xiao

Department of Radiation Oncology Faculty Papers

No abstract provided.

Safety And Efficacy Of Blood Exchange Transfusion For Priapism Complicating Sickle Cell Disease., Samir K. Ballas, David Lyon

Cardeza Foundation for Hematologic Research

BACKGROUND: Priapism is unwanted painful penile erection that affects about 36% of boys and men with sickle cell disease (SCD) most of whom have sickle cell anemia. Clinically, priapism could be stuttering, minor, or major. The first two types are mild, last < 4 h, are usually treated at home, have good prognosis with normal sexual function. The major type of priapism lasts >4 h, associated with severe pain, requires hospitalization; often does not respond to medical treatment and may require shunt surgery. Untreated major priapism and surgical intervention often cause impotence. In this study, we report our 15-year experience in treating adult patients with SCD and major priapism with blood exchange transfusion after being refractory to other medical therapies.

METHODS: …

Cells Activated For Wound Repair Have The Potential To Direct Collective Invasion Of An Epithelium., Brigid M Bleaken, A Sue Menko, Janice Walker

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Mechanisms regulating how groups of cells are signaled to move collectively from their original site and invade surrounding matrix are poorly understood. Here we develop a clinically relevant ex vivo injury invasion model to determine whether cells involved in directing wound healing have invasive function and whether they can act as leader cells to direct movement of a wounded epithelium through a three-dimensional (3D) extracellular matrix (ECM) environment. Similar to cancer invasion, we found that the injured cells invade into the ECM as cords, involving heterotypical cell-cell interactions. Mesenchymal cells with properties of activated repair cells that typically locate to …