Medicine and Health Sciences Commons^™

Thermal Dosimetry For Bladder Hyperthermia Treatment. An Overview., Gerben Schooneveldt, Akke Bakker, Edmond Balidemaj, Rajiv Chopra, Johannes Crezee, Elisabeth D. Geijsen, Josefin Hartmann, Maarten C.C.M. Hulshof, H. Petra Kok, Margarethus M. Paulides, Alejandro Sousa-Escandon, Paul R. Stauffer, Paolo F. Maccarini

Department of Radiation Oncology Faculty Papers

The urinary bladder is a fluid-filled organ. This makes, on the one hand, the internal surface of the bladder wall relatively easy to heat and ensures in most cases a relatively homogeneous temperature distribution; on the other hand the variable volume, organ motion, and moving fluid cause artefacts for most non-invasive thermometry methods, and require additional efforts in planning accurate thermal treatment of bladder cancer. We give an overview of the thermometry methods currently used and investigated for hyperthermia treatments of bladder cancer, and discuss their advantages and disadvantages within the context of the specific disease (muscle-invasive or non-muscle-invasive bladder …

An Atrophic Plaque On The Breast Six Years After Breast Reconstruction Surgery, Michelle Khurana, Richard Torbeck, Young C. Kauh

Department of Dermatology and Cutaneous Biology Faculty Papers

No abstract provided.

Surgical Apgar Score (Sas) Predicts Perioperative Morbidity And Length Of Stay In Patients Undergoing Esophagectomy At A High-Volume Center, Danica Giugliano, Md, Andrew Morgan, Francesco Palazzo, Md, Nathaniel R. Evans Iii, M.D., Ernest L Rosato, Md, Adam C. Berger, Md, Benjamin E Leiby, Phd

Department of Surgery Posters

Background:

Esophagectomy is a procedure that carries considerable morbidity. Many studies have evaluated factors to predict patients at risk and improve clinical outcomes. The aim of this study was to determine whether the SAS predicts complications, length of stay, and anastomotic leak for patients undergoing esophagectomy at a high-volume institution.

Rare Case Of Metastatic Pituitary Disease, Anitha Somasundaram, Md, Kevin D. Judy, Md, Kevin Furlong, Do

Department of Neurosurgery Posters

Background:

Metastatic involvement of the pituitary gland is extremely rare. We present a case of metastatic pituitary disease with panhypopituitarism and diabetes insipidus.

Use Of Propensity Score Matching To Identify A Strong Association Between Health Care Provider Advice Not To Smoke And Quit Attempts Among Mid-Adolescent Smokers, Russell K. Mcintire, Phd, Mph

College of Population Health Posters

Background:

• Nearly 1 out of 7 U.S. adolescents is a current cigarette smoker by the time they leave high school. ¹
• Although almost one third of adolescents who saw a healthcare provider in the past month were advised to quit or avoid tobacco,² research on the influence of provider advice on quit attempts among adolescent smokers has shown mixed results. ³
• These results may be due to selection bias—adolescent smokers who get advice may be different from those who do not on a range of factors including age of initiation, smoking frequency, attitudes toward smoking, exposure to other anti-tobacco …

Literature Review On Hospital Costs For Patients Undergoing Colectomy, Brian P.H. Chen, Scm, Hang Cheng, Martha Romney, Rn, Ms, Jd, Mph, Carine Chia-Wen Hsiao

College of Population Health Posters

Objective:

This study aims to identify the range of direct hospital costs associated with a minimally invasive or open colectomy procedure across different countries.

Poster presented at 2016 ISPOR conference in Washington DC.

Management Considerations Of Massive Hemoptysis While On Extracorporeal Membrane Oxygenation., Harrsion T. Pitcher, Meredith A. Harrison, Colette Shaw, Scott W. Cowan, Hitoshi Hirose, Nicholas C. Cavarocchi

Department of Surgery Faculty Papers

BACKGROUND: Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is a life-saving procedure in patients with both respiratory and cardiac failure. Bleeding complications are common since patients must be maintained on anticoagulation. Massive hemoptysis is a rare complication of ECMO; however, it may result in death if not managed thoughtfully and expeditiously.

METHODS: A retrospective chart review was performed of consecutive ECMO patients from 7/2010-8/2014 to identify episodes of massive hemoptysis. The management of and the outcomes in these patients were studied. Massive hemoptysis was defined as an inability to control bleeding (>300 mL/day) from the endotracheal tube with conventional maneuvers, …

Dual Kidney Allocation Score: A Novel Algorithm Utilizing Expanded Donor Criteria For The Allocation Of Dual Kidneys In Adults, Jill N. D'Souza, Md, Katherine Mckee-Cole, Md, Abigail Strang, Md, Patrick Barth, Md, Aaron Chidekel, Md, Udayan Shah, Md

Department of Otolaryngology - Head and Neck Surgery Posters

Abstract:

Objective The recognition of wound-related complications following pediatric tracheotomy is on the rise. These complications can have a significant impact on clinical course as well as on hospital healthcare costs to the tracheotomy dependent child and family

Methods A tracheotomy database was created in 2000 and reviewed for incidence of major and minor complications.

Setting Tertiary Care Pediatric Referral Center

Results We identified a post-tracheotomy complication rate of 19.9%, of which the most common complication was wound breakdown (65% of complications).

Conclusion Rate of post-tracheotomy wound-care complications is 12.9%. Wound description is subjective and prone to inter-observer variability. A …

Factors Influencing Resection In Locoregional Pancreatic Cancer Patients, Amy Cunningham, Mph, Phd(C), Brian P.H. Chen, Scm, Pharmd, David Delgado, Phd

College of Population Health Posters

Objective:

Identify factors associated with resection in a national sample of locoregional pancreatic cancer patients.

Poster presented at ISPOR conference in Washington DC.

Did A Physician-Targeted Intervention That Reduced Potentially Inappropriate Prescribing To Elderly Patients Also Reduce Related Hospitalizations?, Jacquelyn Mcrae, Pharmd, Sarah E. Hegarty, Pharmd, M. Alcusky, A. Vegesna, S. Varga, S. W. Keith, S. Del Canale, M. Lombardi, Vittorio Maio, Pharmd, Msph

College of Population Health Posters

Objectives:

To determine whether a general practitioner focused intervention aimed at decreasing PIM prescribing in the elderly can decrease the risk of PIM-related hospitalizations.

Poster presented at 2016 ISPOR conference in Washington DC.

Literature Review On Hospital Costs For Patients Undergoing Hysterectomy, Brian P.H. Chen, Scm, Pharmd, Hang Cheng, Martha Romney, Rn, Ms, Jd, Mph, Carine Chia-Wen Hsiao

College of Population Health Posters

Objective:

This study aims to identify the range of direct hospital costs associated with a minimally invasive or abdonimal hysterectomy procedure across different countries.

Poster presented at 2016 ISPOR conference in Washington DC.

Cancer Stem Cell Metabolism., Maria Peiris-Pagès, Ubaldo E. Martinez-Outshoorn, Richard G. Pestell, Federica Sotgia, Michael P Lisanti

Kimmel Cancer Center Papers, Presentations, and Grand Rounds

Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cells also seem to adapt their metabolism to microenvironmental changes by conveniently shifting energy production from one pathway to another, or by acquiring intermediate metabolic phenotypes. Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets.

People In The News

Office of Diversity & Inclusion Initiatives Newsletter

• Edith Mitchell, MD
• Jerry McCauley, MD
• Elizabeth Sophy
• Salam Beah

Thomas Jefferson University Chief Diversity Officer Mr. Joseph Hill

Office of Diversity & Inclusion Initiatives Newsletter

In 2013, Dr. Steve Klasko became President and CEO of Thomas Jefferson University. Amongst the many ideas that he brought with him, he demanded that diversity and inclusion become a part of our daily lives. Diversity is part of the Blueprint for Strategic Action, Jefferson’s strategic plan. One month after his arrival at Jefferson, a communication went out to the Jefferson community that described the importance of an inclusive and diverse environments well as the importance of it being woven into our culture.

Skmc Council On Diversity And Inclusion

Office of Diversity & Inclusion Initiatives Newsletter

The SKMC Council for Diversity and Inclusion (D & I) is charged with enhancing the diversity and inclusiveness of the medical college community to allow us to best achieve our mission in patient care, education and research, and to the ability of our graduates to best serve the heath and health care needs of the public. The Council reviews and assesses the status and effectiveness of diversity and inclusion initiatives within the student, resident and faculty communities of SKMC and make recommendations regarding initiatives, policies, and resources needed to achieve desired outcomes. Headed by Mark L. Tykocinski, MD, the Anthony …

Student Group Activity

Office of Diversity & Inclusion Initiatives Newsletter

Descriptions of the following Student Groups:

• Student National Medical Association
• JeffLGBTQ
• Jewish Student Association
• Jefferson Muslim Society
• Latino Medical Students Association
• Medical Spanish Translator Program
• Diversity Council
• Asian Pacific American Medical Students Association
• Diversity and Inclusion Student Advisory Board

Recruitment

Office of Diversity & Inclusion Initiatives Newsletter

In 2015, SKMC took a team approach to recruitment. A team comprised of students, residents, and faculty, along with the diversity deans staffed recruiting tables at a variety of national venues. SKMC regularly recruits at the AAMC Minority Career Fair, the Student National Medical Association, and the Latino Medical Student Association. At the National Medical Association (the oldest and largest medical association for black physicians) in August 2015, the team included Mr. Joseph Hill, Chief Diversity Officer for Thomas Jefferson University.

Graduate Medical Education

Office of Diversity & Inclusion Initiatives Newsletter

To expand and enhance diversity and inclusion for our resident physicians, three initiatives targeting Graduate Medical Education are underway.

Faculty Initiatives

Office of Diversity & Inclusion Initiatives Newsletter

New URM faculty welcome meeting

Faculty Development-Unconscious Bias Workshop

Support for Minority and women faculty development

Formal Diversity Training

SKMC Search and Hiring Policy

Pipeline Programs

Office of Diversity & Inclusion Initiatives Newsletter

Asstated by the American Association of Medical Colleges, “a medical education program must develop programs or partnerships aimed at broadening diversity among qualified applicants for medical school admission”. Minority doctors comprise about 6 percent of the total U.S. physician population, a number that has not changed since the 1960s, says Traci R. Trice, MD, assistant dean for diversity and student diversity programs. “If you look more specifically at certain populations, particularly black males, the numbers have even gone down,” she notes. Yet African Americans comprise about 15 percent of the general U.S. population and Hispanics or Latinos make up about …

A Message From The Diversity Dean, Dr. Bernard Lopez, Bernard Lopez, Md

Office of Diversity & Inclusion Initiatives Newsletter

Welcome to the first newsletter from the Office of Diversity & Inclusion, intended to reach our students, residents, and faculty and spread awareness about diversity initiatives at the Sidney Kimmel Medical College at Thomas Jefferson University!

25th Annual Grandon Lecture Now In The Jdc, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

The Impact of HealthCare on the 2016 Election by Gail R. Wilensky, PhD, the 25th Annual Dr. Raymond C. Grandon Lecture, is now available in the Jefferson Digital Commons.

Erosion Of Empathy In Primary Care Trainees, Jacquelyn Mcrae, Pharmd, G. Calusi, Mengdan Liu, V. Scognamiglio, E. Messina, L. Polenzani, Vittorio Maio, Pharmd, Msph

College of Population Health Posters

Objective:

To evaluate if empathy among physician residents (trainees) differs dependent on training year and to assess trainees' characteristics associated with higher empathy scores.

Poster presented at 2016 ISPOR conference in Washington DC.

A Review Of Current Quality Metrics For Evaluating Patient-Centered Medical Homes, Stefan Varga, M. Lombardi, Vittorio Maio, Pharmd, Msph

College of Population Health Posters

Objectives:

This review sought to explore the quality metrics that are currently utilized to assess PCMHs

Poster presented at 2016 ISPOR conference in Washington DC.

Adiponectin Ameliorates The Apoptotic Effects Of Paraquat On Alveolar Type Ⅱ Cells Via Improvements In Mitochondrial Function., Yarong He, Liqun Zou, Yaxiong Zhou, Hai Hu, Rong Yao, Yaowen Jiang, Wayne Bond Lau, Tun Yuan, Wen Huang, Zhi Zeng, Yu Cao

Department of Emergency Medicine Faculty Papers

Previous studies have demonstrated that excessive reactive oxygen/nitrogen species (ROS/RNS)‑induced apoptosis is an important feature of the injury to the lung epithelium in paraquat (PQ) poisoning. However the precise mechanisms of PQ‑induced dysfunction of the mitochondria, where ROS/RNS are predominantly produced, remain to be fully elucidated. Whether globular adiponectin (gAd), a potent molecule protective to mitochondria, regulates the mitochondrial function of alveolar type II cells to reduce PQ‑induced ROS/RNS production remains to be investigated. The current study aimed to investigate the precise mechanisms of PQ poisoning in the mitochondria of alveolar type II cells, and to elucidate the role of …

The Structure And Regulation Of Cullin 2 Based E3 Ubiquitin Ligases And Their Biological Functions., Weijia Cai, Haifeng Yang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Cullin-RING E3 ubiquitin ligase complexes play a central role in targeting cellular proteins for ubiquitination-dependent protein turnover through 26S proteasome. Cullin-2 is a member of the Cullin family, and it serves as a scaffold protein for Elongin B and C, Rbx1 and various substrate recognition receptors to form E3 ubiquitin ligases.

MAIN BODY OF THE ABSTRACT: First, the composition, structure and the regulation of Cullin-2 based E3 ubiquitin ligases were introduced. Then the targets, the biological functions of complexes that use VHL, Lrr-1, Fem1b, Prame, Zyg-11, BAF250, Rack1 as substrate targeting subunits were described, and their involvement in diseases …

Suppression Of Progranulin Expression Inhibits Bladder Cancer Growth And Sensitizes Cancer Cells To Cisplatin., Simone Buraschi, Shi-Qiong Xu, Manuela Stefanello, Igor Moskalev, Alaide Morcavallo, Marco Genua, Ryuta Tanimoto, Ruth Birbe, Stephen C. Peiper, Leonard G. Gomella, Antonino Belfiore, Peter C. Black, Renato V. Iozzo, Andrea Morrione

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

We have recently demonstrated a critical role for progranulin in bladder cancer. Progranulin contributes, as an autocrine growth factor, to the transformed phenotype by modulating Akt-and MAPK-driven motility, invasion and anchorage-independent growth. Progranulin also induces F-actin remodeling by interacting with the F-actin binding protein drebrin. In addition, progranulin is overexpressed in invasive bladder cancer compared to normal tissue controls, suggesting that progranulin might play a key role in driving the transition to the invasive phenotype of urothelial cancer. However, it is not established whether targeting progranulin could have therapeutic effects on bladder cancer. In this study, we stably depleted urothelial …

Utilization Of Exercise Prescriptions For Older Adults, David Jeong, Md, Caqsm, Cep, Rmsk, Brooke Salzman, Md, Jeremy Close, Md

Department of Family & Community Medicine Posters

Objective

This study was conducted to investigate

1) Providers` knowledge and physician attitude about Exercise and Physical activity (PA) recommendations for Older Adults (OA)

2) Frequency of utilizing written exercise prescriptions

3) Barriers to using exercise prescriptions in primary care practice

4) Providers’ interest in learning about and utilizing exercise prescriptions

Recurrent Siadh After Switching Citalopram To Very Low Dose Duloxetine In The Elderly, David Jeong, Md, Caqsm, Cep, Rmsk, Patrick Doggett, Md, Kristine Swartz, Md, Lauren Hersh, Md, Brooke Salzman, Md

Department of Family & Community Medicine Posters

Objective

• Duloxetine-induced SIADH has been seldom reported
• This case study emphasizes the importance of suspecting rare adverse effects of recurrent SIADH after switching an SSRI to duloxetine in older adults

The Pennsylvania Emergency Department Geriatric Readiness Project, Adam Perry, Md, Alyssa Sipes, Bs

College of Population Health Posters

BE THE ED DOC – Illustrating Geriatric Readiness

An independent, right handed 81 year old who lives alone trips and falls while walking with her walker. A thorough evaluation at her local ED reveals only a nonoperative right proximal humeral fracture. Her pain is well controlled with immobilization and oral analgesics.

What is her disposition?

• Discharge home with shoulder immobilizer and instructions to call orthopedics in the morning.
• Admit to Telemetry Bed for “Syncope” with orthopedics and cardiology consultations, with subsequent SubAcute Rehabilitation stay.
• Admit to Observation Status for “Ambulatory Dysfunction”.
• Discharge home with her daughter, who lives locally, with …