Medicine and Health Sciences Commons^™

A Narrative Review Of Targeted Therapy In Meningioma, Pituitary Adenoma, And Craniopharyngioma Of The Skull Base., Nina L. Martinez, Omaditya Khanna, Christopher J. Farrell

Department of Neurosurgery Faculty Papers

Management of solid tumors involving the skull base are primarily managed with surgery and radiation, though proximity to important vascular and neuroanatomic structures often limit the extent of resection and permissible radiation dose. Meningiomas are the most common primary brain tumor in adults, and although the majority of skull base meningiomas are low-grade, their location in proximity to critical anatomical structures precludes aggressive surgical resection, and larger tumors are often resistant to radiation treatment. In patients with clinically aggressive, unresectable meningiomas, several molecular biomarkers of angiogenesis, as well as genetic mutations (SMO, AKT1, PIK3CA, KLF4, POLR2, SMARCE1, and TRAF7), have …

A Phase Ii Study Of The Insulin-Like Growth Factor Type I Receptor Inhibitor Imc-A12 In Patients With Metastatic Uveal Melanoma., Jane Mattei, Alexej Ballhausen, Roland Bassett, Michael Shephard, Chandrani Chattopadhyay, Courtney Hudgens, Michael Tetzlaff, Scott Woodman, Takami Sato, Sapna P Patel

Department of Medical Oncology Faculty Papers

Uveal melanoma is a rare and aggressive malignancy and up to half of all patients will develop metastatic disease despite the effective treatment of the primary tumor. Insulin-like growth factors I/II play a fundamental role in the cell migration, proliferation, and apoptosis. IMC-A12, a mAb specifically targets insulin-like growth factor type I receptor, has shown promise in preclinical studies. We performed a multicenter phase II study for patients with metastatic uveal melanoma administered IMC-A12 10 mg/kg IV every two weeks until disease progression or unacceptable toxicity. The primary endpoint was objective response (proportion of patients with complete or partial response), …

A Systematic Review Of Home-Based Dietary Interventions During Radiation Therapy For Cancer., Taylor H Allenby, Megan L Crenshaw, Katlynn Mathis, Colin E Champ, Nicole L Simone, Kathryn H Schmitz, Leila T Tchelebi, Nicholas G Zaorsky

Department of Radiation Oncology Faculty Papers

Purpose: Our objectives are to assess (1) the acceptability and feasibility of dietary interventions for patients undergoing radiation therapy (RT), and (2) the impact of dietary interventions on patient reported outcomes, toxicities, and survival.

Methods: A PICOS/PRISMA/MOOSE selection protocol was used to include articles that evaluate adding dietary interventions to patients receiving RT. Acceptability was defined as (# accepting/# approached); feasibility was (# completing/# approached). Patient-reported outcomes were reported based on questionnaires used in each study and survival was measured from the date of diagnosis until death in each study. Level of evidence was assessed with Center for Evidence-Based Medicine …

Lessons To Be Learned: Case Reports And Complications, John Lawrence, Md, David L. Fischman

Division of Cardiology Faculty Papers

No abstract provided.

Bullous Hemorrhagic Sweet Syndrome With Cryptococcoid Neutrophils In Patients Positive For Antineutrophil Cytoplasmic Antibody Without Primary Vasculitis., Alex Sherban, Collin Fuller, Mansha Sethi, Eleni Mcgeehin, Dawn Hirokawa, Courtney Guerrieri, Jason B. Lee, Md, Sherry Yang

Department of Dermatology and Cutaneous Biology Faculty Papers

No abstract provided.

Looking Beyond The Numbers: Quality Assurance Procedures In The Global Network For Women's And Children's Health Research Maternal Newborn Health Registry., Ana Garces, Emily Macguire, Holly L Franklin, Norma Alfaro, Gustavo Arroyo, Lester Figueroa, Shivaprasad S Goudar, Sarah Saleem, Fabian Esamai, Archana Patel, Elwyn Chomba, Antoinette Tshefu, Rashidul Haque, Jacquelyn K Patterson, Edward A Liechty, Richard J Derman, Waldemar A Carlo, William Petri, Marion Elizabeth M Koso-Thomasmcclure, Robert L Goldenberg, Patricia Hibberd, Nancy F Krebs

Global Health Articles

BACKGROUND: Quality assurance (QA) is a process that should be an integral part of research to protect the rights and safety of study participants and to reduce the likelihood that the results are affected by bias in data collection. Most QA plans include processes related to study preparation and regulatory compliance, data collection, data analysis and publication of study results. However, little detailed information is available on the specific procedures associated with QA processes to ensure high-quality data in multi-site studies.

METHODS: The Global Network for Women's and Children's Health Maternal Newborn Health Registy (MNHR) is a prospective population-based registry …

Diagnostic Journey And Impact Of Enzyme Replacement Therapy For Mucopolysaccharidosis Iva: A Sibling Control Study., Can Ficicioglu, Dena R Matalon, Nicole Luongo, Caitlin Menello, Tracy Kornafel, Andrew J Degnan

Abington Jefferson Health Papers

BACKGROUND: Mucopolysaccharidosis (MPS) IVA, also known as Morquio A syndrome, is a rare autosomal recessive lysosomal storage disorder caused by a deficiency in the enzyme N-acetylgalactosamine-6-sulfatase. Early recognition, diagnosis, and treatment of this progressive, multisystem disease by enzyme replacement therapy (ERT) can lead to improved outcomes and reduced mortality.

METHODS: This report documents the diagnostic journey and treatment with ERT of three siblings with MPS IVA. Clinical outcome measures included growth, endurance, imaging, cardiac, respiratory, ophthalmology, and laboratory evaluations.

RESULTS: Three siblings, diagnosed at 14.7, 10.1, and 3.2 years of age, demonstrated clinical improvement with weekly infusions of 2.0 mg/kg …

Hemoglobin Concentrations And Adverse Birth Outcomes In South Asian Pregnant Women: Findings From A Prospective Maternal And Neonatal Health Registry, Sumera Aziz Ali, Shiyam Sunder Tikmani, Sarah Saleem, Archana B Patel, Patricia L Hibberd, Shivaprasad S Goudar, Sangappa Dhaded, Richard J Derman, Janet L Moore, Elizabeth M Mcclure, Robert L Goldenberg

Global Health Articles

BACKGROUND: While the relationship between hemoglobin (Hb) concentrations and pregnancy outcomes has been studied often, most reports have focused on a specific Hb cutoff used to define anemia. Fewer studies have evaluated pregnancy outcomes across the entire range of Hb values. Moreover, to date, most studies of the relationship of Hb concentrations to pregnancy outcomes have been done in high-income countries. Thus, we have sought to determine the relationship between the range of maternal Hb concentrations and adverse birth outcomes among South Asian pregnant women.

METHODS: For this study, we used data collected from two South Asian countries (Pakistan - …

Neonatal Deaths In Rural Karnataka, India 2014-2018: A Prospective Population-Based Observational Study In A Low-Resource Setting., Sangappa M Dhaded, Manjunath S Somannavar, Janet L Moore, Elizabeth M Mcclure, Sunil S Vernekar, S Yogeshkumar, Avinash Kavi, Umesh Y Ramadurg, Tracy L Nolen, Robert L Goldenberg, Richard J Derman, Shivaprasad S Goudar

Global Health Articles

BACKGROUND: Neonatal mortality causes a substantial proportion of the under-5 mortality in low and middle-income countries (LMIC).

METHODS: We undertook a prospective, population-based research study of pregnant women residing in defined geographic areas in the Karnataka State of India, a research site of the Global Network for Women's and Children's Health Research. Study staff collected demographic and health care characteristics on eligible women enrolled with neonatal outcomes obtained at delivery and day 28. Cause of neonatal mortality at day 28 was assigned by algorithm using prospectively defined variables.

RESULTS: From 2014 to 2018, the neonatal mortality rate was 24.5 per …

The Global Network Maternal Newborn Health Registry: A Multi-Country, Community-Based Registry Of Pregnancy Outcomes., Elizabeth M. Mcclure, Ana L. Garces, Patricia L. Hibberd, Janet L. Moore, Shivaprasad S. Goudar, Sarah Saleem, Fabian Esamai, Archana Patel, Elwyn Chomba, Adrien Lokangaka, Antoinette Tshefu, Rashidul Haque, Carl L. Bose, Edward A. Liechty, Nancy F. Krebs, Richard J. Derman, Waldemar A. Carlo, William Petri, Marion Koso-Thomas, Robert L Goldenberg

Global Health Articles

BACKGROUND: The Global Network for Women's and Children's Health Research (Global Network) conducts clinical trials in resource-limited countries through partnerships among U.S. investigators, international investigators based in in low and middle-income countries (LMICs) and a central data coordinating center. The Global Network's objectives include evaluating low-cost, sustainable interventions to improve women's and children's health in LMICs. Accurate reporting of births, stillbirths, neonatal deaths, maternal mortality, and measures of obstetric and neonatal care is critical to determine strategies for improving pregnancy outcomes. In response to this need, the Global Network developed the Maternal Newborn Health Registry (MNHR), a prospective, population-based registry …

Neonatal Deaths In Infants Born Weighing ≥ 2500 G In Low And Middle-Income Countries., Sarah Saleem, Farnaz Naqvi, Elizabeth M. Mcclure, Kayla J. Nowak, Shiyam Sunder Tikmani, Ana L. Garces, Patricia L. Hibberd, Janet L. Moore, Tracy L. Nolen, Shivaprasad S. Goudar, Yogesh Kumar, Fabian Esamai, Irene Marete, Archana B. Patel, Elwyn Chomba, Musaku Mwenechanya, Carl L. Bose, Edward A. Liechty, Nancy F. Krebs, Richard Derman, Waldemar A. Carlo, Antoinette Tshefu, Marion Koso-Thomas, Sameen Siddiqi, Robert L. Goldenberg

Global Health Articles

BACKGROUND: Babies born weighing ≥ 2500 g account for more than 80% of the births in most resource-limited locations and for nearly 50% of the 28-day neonatal deaths. In contrast, in high-resource settings, 28-day neonatal mortality among this group represents only a small fraction of the neonatal deaths. Yet mortality risks for birth weight of ≥ 2500 g is limited. Knowledge regarding the factors associated with mortality in these babies will help in identifying interventions that can reduce mortality.

METHODS: The Global Network's Maternal Newborn Health Registry (MNHR) is a prospective, population-based observational study that includes all pregnant women and …

Evaluating The Effect Of Care Around Labor And Delivery Practices On Early Neonatal Mortality In The Global Network's Maternal And Newborn Health Registry., Archana B. Patel, Elizabeth M. Simmons, Sowmya R. Rao, Janet Moore, Tracy L. Nolen, Robert L Goldenberg, Shivaprasad S. Goudar, Manjunath S. Somannavar, Fabian Esamai, Paul Nyongesa, Ana L. Garces, Elwyn Chomba, Musaku Mwenechanya, Sarah Saleem, Farnaz Naqvi, Melissa Bauserman, Sherri Bucher, Nancy F. Krebs, Richard J. Derman, Waldemar A. Carlo, Marion Koso-Thomas, Elizabeth M. Mcclure, Patricia L. Hibberd

Global Health Articles

BACKGROUND: Neonatal deaths in first 28-days of life represent 47% of all deaths under the age of five years globally and are a focus of the United Nation's (UN's) Sustainable Development Goals. Pregnant women are delivering in facilities but that does not indicate quality of care during delivery and the postpartum period. The World Health Organization's Essential Newborn Care (ENC) package reduces neonatal mortality, but lacks a simple and valid composite index that measures its effectiveness.

METHODS: Data on 5 intra-partum and 3 post-partum practices (indicators) recommended as part of ENC, routinely collected in NICHD's Global Network's (GN) Maternal Newborn …

Maternal Mortality Following Thromboembolism; Incidences And Prophylaxis Strategies., Mahboobeh Shirazi, Behrokh Sahebdel, Mehnoosh Torkzaban, Elham Feizabad, Marjan Ghaemi

Department of Radiology Faculty Papers

BACKGROUND: Thromboembolism is one of the main causes of maternal mortality, which can be prevented in many cases. The present study was designed to investigate the incidence and prophylaxis strategies for maternal mortality following thromboembolism in postnatal.

METHODS: In this case series study, the data of the mortality cases were extracted according to the ethical and security standards of the Ministry of Health of the country and compared with a healthy control group. The thromboembolism risk factors measured and scored using a questionnaire entitled "the evaluation of risk factors for maternal mortality following thromboembolism during pregnancy, labor, or post-partum".

RESULTS: …

Author Reply., Selin Isguven, Paul H. Chung, Priscilla Machado, Lauren J. Delaney, Antonia F. Chen, Flemming Forsberg, Noreen J. Hickok

Department of Radiology Faculty Papers

No abstract provided.

The Relationship Between Birth Intervals And Adverse Maternal And Neonatal Outcomes In Six Low And Lower-Middle Income Countries., Melissa Bauserman, Kayla Nowak, Tracy L Nolen, Jackie Patterson, Adrien Lokangaka, Antoinette Tshefu, Archana B Patel, Patricia L Hibberd, Ana L Garces, Lester Figueroa, Nancy F Krebs, Fabian Esamai, Edward A Liechty, Waldemar A Carlo, Elwyn Chomba, Musaku Mwenechanya, Shivaprasad S Goudar, Umesh Ramadurg, Richard J Derman, Sarah Saleem, Saleem Jessani, Marion Koso-Thomas, Elizabeth M Mcclure, Robert L Goldenberg, Carl Bose

Global Health Articles

BACKGROUND: Due to high fertility rates in some low and lower-middle income countries, the interval between pregnancies can be short, which may lead to adverse maternal and neonatal outcomes.

METHODS: We analyzed data from women enrolled in the NICHD Global Network Maternal Newborn Health Registry (MNHR) from 2013 through 2018. We report maternal characteristics and outcomes in relationship to the inter-delivery interval (IDI, time from previous delivery [live or stillborn] to the delivery of the index birth), by category of 6-17 months (short), 18-36 months (reference), 37-60 months, and 61-180 months (long). We used non-parametric tests for maternal characteristics, and …

Stillbirth 2010-2018: A Prospective, Population-Based, Multi-Country Study From The Global Network., Elizabeth M. Mcclure, Sarah Saleem, Shivaprasad S. Goudar, Ana Garces, Ryan Whitworth, Fabian Esamai, Archana B. Patel, Shiyam Sunder Tikmani, Musaku Mwenechanya, Elwyn Chomba, Adrien Lokangaka, Carl L. Bose, Sherri Bucher, Edward A. Liechty, Nancy F. Krebs, S Yogesh Kumar, Richard J. Derman, Patricia L. Hibberd, Waldemar A. Carlo, Janet L. Moore, Tracy L. Nolen, Marion Koso-Thomas, Robert L. Goldenberg

Global Health Articles

BACKGROUND: Stillbirth rates are high and represent a substantial proportion of the under-5 mortality in low and middle-income countries (LMIC). In LMIC, where nearly 98% of stillbirths worldwide occur, few population-based studies have documented cause of stillbirths or the trends in rate of stillbirth over time.

METHODS: We undertook a prospective, population-based multi-country research study of all pregnant women in defined geographic areas across 7 sites in low-resource settings (Kenya, Zambia, Democratic Republic of Congo, India, Pakistan, and Guatemala). Staff collected demographic and health care characteristics with outcomes obtained at delivery. Cause of stillbirth was assigned by algorithm.

RESULTS: From …

Innovator - Spring 2020

Innovator

05 - Message from the President

08 - The Past is a Prologue

15 - Shrinking World/Expanding Horizons

16 - The Nexus: News at Jefferson

20 - Jefferson Hits the Runway at NYFW

22 - A Game Changer

26 - Binge Swatching

30 - Breaking Down the Walls

38 - Coming Full Circle

44 - Question and Innovate

46 - Designer Health

50 - The Site is the Star

54 - Transcend and Include

60 - Reimagine

64 - Ram Roundup

68 - Class Notes

74 - In Memory

78 - Triva

Innovator - Winter 2020

Innovator

8 - A MESSAGE FROM THE PRESIDENT

10 - WHAT’S HAPPENING AT JEFFERSON

16 - DEFINING THE FUTURE OF LEARNING AND WORK
How well are institutions of higher education preparing their graduates for the realities of work in the 21st century?

26 - IT’S IN OUR DNA
Innovative partnership leads to Jefferson Institute for Bioprocessing.

32 - JEFFERSON IS GLOBAL
Jefferson’s study away program provides life-changing experiences for students.

36 - PURSUING KNOWLEDGE AND IMPACT
Provost Mark L. Tykocinski, MD, explores the different research initiatives happening across Jefferson.

38 - LIVING THE DREAM
Jefferson grad orbits among the stars like …

Innovator - Fall 2016

Innovator

4 - What’s Now: Impact Edition

6 - Building the Futures Center

9 - Snapshots of Impact

12 - The Six Steps to Success

16 - On Common Ground

18 - Opening the Door of Opportunity

20 - A Team Effort

24 - The Clash of Tradition and Technology

26 - Enriching the Student Experience

27 - Who Named the Rams?

27 - Financial Information

Innovator - Winter 2015

Innovator

4 - What’s Now: Impact Edition

6 - Athletics

8 - W. W. Smith Scholarship

12 - A Full Embrace

18 - Donor Honor Roll

23 - Financial Information

Innovator - Fall 2014

Innovator

4 - What’s Now: Impact Edition

6 - Scholarships

8 - Term Chairs

10 - Power to Innovate Campaign

20 - Donor Profile: Handsel Minyard

23 - Financial Information

Innovator - Fall/Winter 2013

Innovator

1 - THE BIG PICTURE

8 - WHAT’S NOW

16 - PINBOARD

17 - MIKE MADE THAT
Mike Leonard, academic dean of the School of Design and Engineering, gives us the inside story about his role in the invention of just about everything.

20 - MEET THE NEW BOARD CHAIR
Entrepreneur and education advocate, Eileen Martinson ’86, brings her passion and expertise for smart technology and education to her new role as Board Chair.

24 - THE DEC CENTER
Built to evolve as curricula changes, the DEC Center has quickly become the campus’ new academic hub.

26 - CHARTING THE …

Innovator - Fall 2012

Innovator

02 - A TRANSFORMATIVE GIFT
With his donation of $15 million, the largest single gift in University history, in support of the Kanbar College of Design, Engineering and Commerce, Maurice Kanbar ’52, H’03 continues his unwavering support of his alma mater.

06 - PRESIDENT SPINEELI COMMENTARY
President Spinelli, a leading authority in entrepreneurship, describes the experience of teaching innovation to freshmen.

08 - WHAT'S THE PROBLEM?
Freshmen in the Kanbar College of Design, Engineering and Commerce become professionals and learn how to turn problems into opportunities by working in real-world settings right from the start of their college careers.

12 …

Innovator - Summer 2011

Innovator

02 - LIVING IN YOUR GENES
Through its nationally ranked physician assistant studies program — led by insightful faculty and an award-winning champion of genetic literacy education — PhilaU is transforming a generation to “think genetically.”

06 - PRESIDENT SPINELLI COMMENTARY
New College structure maximizes students’ experiences

08 - QUIET ON THE SET
Emmy-nominated alumna Kim Wannop ’99 dresses six or more sets each week for Fox’s hit TV show Bones.

12 - MEET RON KANDER, PH.D.
The executive dean of the College of Design, Engineering and Commerce leads a revolutionary, transdisciplinary curriculum.

18 - NEWS

22 - PROFILES

24 …

Innovator - Fall 2010

Innovator

2 - TEXTILE LEGACY LEADING TO BIOMEDICAL BREAKTHROUGHS
PhilaU researchers developing a cardiac patch

6 - PRESIDENT SPINELLI COMMENTARY
A Great Return on Investment

8 - THE BUSINESS OF FASHION
Fashion thinking zeros in on bottom line

14 - MEN IN FLIGHT
Guggenheim Fellow chronicles history of male flight attendants

18 - PHILAU NEWS

22 - Q&A WITH NATHAN VANHOOK ’03
Alumnus designs new Nike shoe “Aina Chukka”

24 - PROFILES

28 - PHILAU AROUND THE WORLD
Alumni, faculty and students’ global impact

33 - AWARDS AND HONORS

34 - A THIRD DIMENSION TO THE INTERNATIONAL BUSINESS EXPERIENCE
Faculty commentary …

Innovator - Winter 2010

Innovator

2 - STEPPING FORWARD AS A NATIONAL MODEL
PhilaU takes a leadership role in green education

6 - 125 THINGS THAT MAKE PHILAU GREAT
Celebrating our 125th Anniversary

12 - PRESIDENT SPINELLI COMMENTARY
A Solid Foundation for the 21st Century

14 - NEW VISION FOR THE ACADEMY
A day in the life of Provost Randy Swearer

18 - STRATEGIC INITIATIVES
Developing the model for professional education in the 21st century

22 - PROFILES

24 - TRUSTEE UPDATE

26 - PHILAU NEWS

31 - AWARDS AND HONORS

32 - EMBRACING THE NEW WORLD OF PERSONALIZED MEDICINE
Faculty commentary by Michael A. …

Cancer-Associated Fibroblast Density, Prognostic Characteristics, And Recurrence In Head And Neck Squamous Cell Carcinoma: A Meta-Analysis., Alexander M Knops, Andrew South, Ulrich Rodeck, Ubaldo Martinez-Outschoorn, Larry A Harshyne, Jennifer Johnson, Adam J Luginbuhl, Joseph M Curry

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Introduction: The progression and clinical course of head and neck squamous cell carcinoma (HNSCC) relies on complex interactions between cancer and stromal cells in the tumor microenvironment (TME). Among the most abundant of these stromal cells are cancer-associated fibroblasts (CAFs). While their contribution to tumor progression is widely acknowledged, and various CAF-targeted treatments are under development, the relationship between CAF density and the clinicopathologic course of HNSCC has not been clearly defined. Here we examine the published evidence investigating the relationship of cancer-associated fibroblasts to local recurrence and indicators of prognostic significance in HNSCC.

Methods: We conducted a meta-analysis of …

Cancer-Associated Fibroblast Density, Prognostic Characteristics, And Recurrence In Head And Neck Squamous Cell Carcinoma: A Meta-Analysis., Alexander M Knops, Andrew South, Ulrich Rodeck, Ubaldo Martinez-Outschoorn, Larry Harshyne, Phd, Jennifer Johnson, Md, Adam J Luginbuhl, Joseph M Curry

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Introduction: The progression and clinical course of head and neck squamous cell carcinoma (HNSCC) relies on complex interactions between cancer and stromal cells in the tumor microenvironment (TME). Among the most abundant of these stromal cells are cancer-associated fibroblasts (CAFs). While their contribution to tumor progression is widely acknowledged, and various CAF-targeted treatments are under development, the relationship between CAF density and the clinicopathologic course of HNSCC has not been clearly defined. Here we examine the published evidence investigating the relationship of cancer-associated fibroblasts to local recurrence and indicators of prognostic significance in HNSCC.

Methods: We conducted a meta-analysis of …

What Is Population Health? Ten Years On…., Mitchell Kaminski

College of Population Health Faculty Papers

No abstract provided.

Medical Therapy Vs Early Revascularization In Diabetics With Chronic Total Occlusions: A Meta-Analysis And Systematic Review, Muhammad Shayan Khan, Farhad Sami, Hemindermeet Singh, Waqas Ullah, Ma'en Al-Dabbas, Khalid Hamid Changal, Tanveer Mir, Zain Ali, Ameer Kabour

Abington Jefferson Health Papers

BACKGROUND: Management of chronic total occlusions (CTO) in diabetics is challenging, with a recent trend towards early revascularization [ER: Percutaneous coronary intervention (PCI) and bypass grafting] instead of optimal medical therapy (OMT). We hypothesize that ER improves morbidity and mortality outcomes in diabetic patients with CTOs as compared to OMT.

AIM: To determine the long term clinical outcomes and to compare morbidity and mortality between OMT and ER in diabetic patients with CTOs.

METHODS: Potentially relevant published clinical trials were identified in Medline, Embase, chemical abstracts and Biosis (from start of the databases till date) and pooled hazard ratios (HR) …