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Articles 5101 - 5130 of 14928

Full-Text Articles in Medicine and Health Sciences

Postoperative Aspiration Pneumonia (Popna) Prevention Protocol, R. Lamm, Md, D. Pace, Md, B. Till, Md, B. Creisher, J. Curran, E. Foecke Munden, J. Williamson, Iii, S. Cowan, Md, C. Costanzo, Md, Harish Lavu, Md May 2021

Postoperative Aspiration Pneumonia (Popna) Prevention Protocol, R. Lamm, Md, D. Pace, Md, B. Till, Md, B. Creisher, J. Curran, E. Foecke Munden, J. Williamson, Iii, S. Cowan, Md, C. Costanzo, Md, Harish Lavu, Md

Health Equity and Quality Improvement (HEQI) Summit

  • Postoperative pneumonia increases morbidity, mortality, length of stay, and hospital costs up to $12,000-$40,000 per patient
  • TJUH Center City ranked in the top 3rd - 4th quartile of pulmonary complications on the 2020 National Surgical Quality Improvement Program perioperative review
  • ICOUGH protocol: widely accepted, standardized set of post-operative interventions to reduce pneumonia incidence
  • Survey design: measure ICOUGH compliance before and after implementation of resident note checklist in EPIC


Improving Advanced Care Planning Discussion And Documentation, Justin Robbins, Md, Bharaniabirami Rajaram, Md, Patrick Kukulich, Md, Danielle Verghese, Md, Dianna Cheney-Peters, Md May 2021

Improving Advanced Care Planning Discussion And Documentation, Justin Robbins, Md, Bharaniabirami Rajaram, Md, Patrick Kukulich, Md, Danielle Verghese, Md, Dianna Cheney-Peters, Md

Health Equity and Quality Improvement (HEQI) Summit

Our goal is to improve ACP discussion and documentation in patients above the age of 65 in our Jefferson Hospital Ambulatory Practice (JHAP) resident clinic. By instituting procedural changes within the EMR and the clinic, as well as improving provider education, we hope that residents can carry out a comprehensive and streamlined discussion regarding advanced care planning. We will institute these changes over the next 3 months, and we predict that there will be an increase in ACP discussion and uploading of appropriate documentation to 50% and 25%, respectively.


Improving Colon Cancer Screening Rates In An Ambulatory Resident Clinic, Ashima Oza, Md, Tina Boortalary, Md, Elizabeth Chin, Md, Tudor Sturzoiu, Md, John Wallis, Md, Sonia Bharel, Md May 2021

Improving Colon Cancer Screening Rates In An Ambulatory Resident Clinic, Ashima Oza, Md, Tina Boortalary, Md, Elizabeth Chin, Md, Tudor Sturzoiu, Md, John Wallis, Md, Sonia Bharel, Md

Health Equity and Quality Improvement (HEQI) Summit

In the US, colorectal cancer (CRC) is the third leading cause of cancer-related deaths. According to the 2018 CDC Behavioral Risk Factor Surveillance System survey, 68.8% of US adults between 50 and 75 were up to date on colorectal screening (CRCS) across all screening modalities. In light of the COVID-19 pandemic, screening has dropped even further and is still 50% below pre-pandemic levels. At Jefferson, our CRCS rate is below the national average at 55.4%. Given the importance of regular screening for CRC prevention, this is clearly inadequate. There are several barriers to completing an invasive screening modality like a …


A Safety Assessment Of The Re-Opening Of An Academic Medical Center Outpatient Endoscopy Unit During The Covid-19 Pandemic, Scott Manski, Christopher Schmoyer, Alice Pang, Richard Denicola, Amy Javia, Melissa Vitolo, Linda Yan, Christopher Cao, Brianna Shinn, Divya Chalikonda, Giselle Mahoro, Ritu Nahar, Joshua Lieberman, Micaela Gernhardt, Neveda Murugesan, Alexandra Leto, Ryan Erwin, Taylor Kavanagh, Stephanie Moleski, Robert Coben, Mitchell Conn May 2021

A Safety Assessment Of The Re-Opening Of An Academic Medical Center Outpatient Endoscopy Unit During The Covid-19 Pandemic, Scott Manski, Christopher Schmoyer, Alice Pang, Richard Denicola, Amy Javia, Melissa Vitolo, Linda Yan, Christopher Cao, Brianna Shinn, Divya Chalikonda, Giselle Mahoro, Ritu Nahar, Joshua Lieberman, Micaela Gernhardt, Neveda Murugesan, Alexandra Leto, Ryan Erwin, Taylor Kavanagh, Stephanie Moleski, Robert Coben, Mitchell Conn

Health Equity and Quality Improvement (HEQI) Summit

  • This study aimed to assess outcomes and satisfaction among patients undergoing outpatient endoscopic procedures during the COVID-19 pandemic
  • Identifying the rates of COVID-19 symptom development and post procedure testing would provide critical information on patient safety
  • Assessment of patient experiences would serve as a guide for potential areas of improvement
  • We predicted that with proper protocols in place, outpatient endoscopy was a safe and positive experience


Improving The Virtual Neurosurgery Residency Interview Experience, Ellina Hattar, Md, Omaditya Khanna, Md, Ritam Ghosh, Md, Nikolaos Mouchtouris, Md, Kevin Hines, Md, Daniel Franco, Md, Michelle Hoffman, James S. Harrop, Md, Ashwini D. Sharan, Md May 2021

Improving The Virtual Neurosurgery Residency Interview Experience, Ellina Hattar, Md, Omaditya Khanna, Md, Ritam Ghosh, Md, Nikolaos Mouchtouris, Md, Kevin Hines, Md, Daniel Franco, Md, Michelle Hoffman, James S. Harrop, Md, Ashwini D. Sharan, Md

Health Equity and Quality Improvement (HEQI) Summit

The residency selection process has proven a challenge in the face of the Covid-19 pandemic. In the neurosurgery match, residents are chosen based on objective metrics as well as their ability to effectively work as part of a team tasked with caring for medically complex patients faced with neurosurgical conditions. As there remain limitations on the number of externships students could participate in and the Step 1 examination is expected to be reported as either pass or fail in years to come, we will have fewer objective metrics to review in the student application. We conducted a study to best …


Introduction Of Gi Wellness Committee To Reduce Gi Fellow Burnout And Improve Wellness., Richard P. Denicola, Md, Melissa A. Vitolo, Md, Ritu Nahar, Md, Jorge Prieto, Md, Stephanie Moleski, Md May 2021

Introduction Of Gi Wellness Committee To Reduce Gi Fellow Burnout And Improve Wellness., Richard P. Denicola, Md, Melissa A. Vitolo, Md, Ritu Nahar, Md, Jorge Prieto, Md, Stephanie Moleski, Md

Health Equity and Quality Improvement (HEQI) Summit

Gastroenterology (GI) fellowship is an arduous process which predisposes fellows to fatigue and burnout.

Our baseline survey showed a large number of our fellows to be in danger of burnout.

Aims for Improvement

  • To improve the overall wellness of GI fellows, identify stressors and reduce incidence of burnout.
  • The goal for the first 6 months of operation is to demonstrate improvement in Mini ReZ survey scores by 25% at starting from Sept 1st, 2020.


Improving Follow Up Compliance For Patients With Sleep Disordered Breathing At Jefferson Sleep Center, E. Fares, Md, A. Ananth, Md, Z. Fast, Md May 2021

Improving Follow Up Compliance For Patients With Sleep Disordered Breathing At Jefferson Sleep Center, E. Fares, Md, A. Ananth, Md, Z. Fast, Md

Health Equity and Quality Improvement (HEQI) Summit

Despite the high effectiveness of CPAP therapy, patient adherence remains variable and a hurdle towards appropriate treatment of their sleep-disordered breathing.

Patients often stop using their CPAP and are then lost to follow-up, which increases their risk of previously mentioned complications that are associated with OSA.

Goals for Improvement

To increase the follow-up rate for patients with OSA.


Improving Sensitivity To And Inclusivity Of Lgbt Older Adults In An Urban Geriatric Practice, Elizabeth Spina, Do, Brooke Salzman, Md, Michael Danielewicz, Md, David Grifith, John Liantonio, Md, Mba, Hmdc May 2021

Improving Sensitivity To And Inclusivity Of Lgbt Older Adults In An Urban Geriatric Practice, Elizabeth Spina, Do, Brooke Salzman, Md, Michael Danielewicz, Md, David Grifith, John Liantonio, Md, Mba, Hmdc

Health Equity and Quality Improvement (HEQI) Summit

CHA’s overall goal is to improve the care delivered to LGBT older adults.

Step 1: Needs assessment with provider and staff survey (Fall 2020)
Step 2:
Implementation of SAGE training and provider education (Fall/Winter 2020) Step 3 (this study): Needs assessment with community-dwelling LGBT older adults (Spring 2021)


Improving Rates Of Nephrology Referral For Patients With Chronic Kidney Disease In Resident Clinic, Akanksha Arya, Md, Rabia Iqbal, Md, Rahed Mohammed, Md, Neveda Murugesan, Md, Jillian Zavodnick, Md May 2021

Improving Rates Of Nephrology Referral For Patients With Chronic Kidney Disease In Resident Clinic, Akanksha Arya, Md, Rabia Iqbal, Md, Rahed Mohammed, Md, Neveda Murugesan, Md, Jillian Zavodnick, Md

Health Equity and Quality Improvement (HEQI) Summit

  • According to the KDIGO (Kidney Disease Improving Global Outcomes), evaluation by a nephrologist is recommended for patients with CKD stage 4 or higher (corresponding to a GFR of 30 or lower).
  • Studies have shown that patients who are not referred to a nephrologist or referred later suffer from increased complications of renal disease, accelerated progression to ESRD, and have an increased overall mortality rate.
  • At Jefferson Hospital Ambulatory Practice (JHAP), we noted decreased rates of nephrology follow-up in our patients with chronic kidney disease stage 4 and 5.
  • We identified that the most prevalent reason for the decreased referral rates …


Plasma Adenosine Deaminase (Ada)-1 And -2 Demonstrate Robust Ontogeny Across The First Four Months Of Human Life., Oludare A. Odumade, Alec L. Plotkin, Jensen Pak, Olubukola T. Idoko, Matthew A. Pettengill, Tobias R. Kollmann, Al Ozonoff, Beate Kampmann, Ofer Levy, Kinga K. Smolen May 2021

Plasma Adenosine Deaminase (Ada)-1 And -2 Demonstrate Robust Ontogeny Across The First Four Months Of Human Life., Oludare A. Odumade, Alec L. Plotkin, Jensen Pak, Olubukola T. Idoko, Matthew A. Pettengill, Tobias R. Kollmann, Al Ozonoff, Beate Kampmann, Ofer Levy, Kinga K. Smolen

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Background: Human adenosine deaminases (ADAs) modulate the immune response: ADA1

Methods: In a subgroup of the EPIC002-study, clinical data and plasma samples were collected from 540 Gambian infants at four time-points: day of birth; first week of life; one month of age; and four months of age. Concentrations of total extracellular ADA, ADA1, and ADA2 were measured by chromogenic assay and evaluated in relation to clinical data. Plasma cytokines/chemokine were measured across the first week of life and correlated to ADA concentrations.

Results: ADA2 demonstrated a steady rise across the first months of life, while ADA1 concentration significantly decreased 0.79-fold …


Sepsis In Two Hospitals In Rwanda: A Retrospective Cohort Study Of Presentation, Management, Outcomes, And Predictors Of Mortality., Dennis A Hopkinson, Jean Paul Mvukiyehe, Sudha P Jayaraman, Aamer A Syed, Myles Dworkin, Willy Mucyo, Thierry Cyuzuzo, Anne Tuyizere, Christian Mukwesi, Gaston Nyirigira, Paulin R Banguti, Elisabeth D Riviello May 2021

Sepsis In Two Hospitals In Rwanda: A Retrospective Cohort Study Of Presentation, Management, Outcomes, And Predictors Of Mortality., Dennis A Hopkinson, Jean Paul Mvukiyehe, Sudha P Jayaraman, Aamer A Syed, Myles Dworkin, Willy Mucyo, Thierry Cyuzuzo, Anne Tuyizere, Christian Mukwesi, Gaston Nyirigira, Paulin R Banguti, Elisabeth D Riviello

Student Papers, Posters & Projects

PURPOSE: Few studies have assessed the presentation, management, and outcomes of sepsis in low-income countries (LICs). We sought to characterize these aspects of sepsis and to assess mortality predictors in sepsis in two referral hospitals in Rwanda.

MATERIALS AND METHODS: This was a retrospective cohort study in two public academic referral hospitals in Rwanda. Data was abstracted from paper medical records of adult patients who met our criteria for sepsis.

RESULTS: Of the 181 subjects who met eligibility criteria, 111 (61.3%) met our criteria for sepsis without shock and 70 (38.7%) met our criteria for septic shock. Thirty-five subjects (19.3%) …


Female With Intermittently Bleeding Abdominal Wall Mass., Evan Osterman, Rebecca Lisowski, Arthur Au May 2021

Female With Intermittently Bleeding Abdominal Wall Mass., Evan Osterman, Rebecca Lisowski, Arthur Au

Department of Emergency Medicine Faculty Papers

No abstract provided.


Timing Of Home Health Care Initiation And 30-Day Rehospitalizations Among Medicare Beneficiaries With Diabetes By Race And Ethnicity., Jamie M Smith, Haiqun Lin, Charlotte Thomas-Hawkins, Jennifer Tsui, Olga F Jarrín May 2021

Timing Of Home Health Care Initiation And 30-Day Rehospitalizations Among Medicare Beneficiaries With Diabetes By Race And Ethnicity., Jamie M Smith, Haiqun Lin, Charlotte Thomas-Hawkins, Jennifer Tsui, Olga F Jarrín

College of Nursing Faculty Papers & Presentations

Older adults with diabetes are at elevated risk of complications following hospitalization. Home health care services mitigate the risk of adverse events and facilitate a safe transition home. In the United States, when home health care services are prescribed, federal guidelines require they begin within two days of hospital discharge. This study examined the association between timing of home health care initiation and 30-day rehospitalization outcomes in a cohort of 786,734 Medicare beneficiaries following a diabetes-related index hospitalization admission during 2015. Of these patients, 26.6% were discharged to home health care. To evaluate the association between timing of home health …


Intravitreal Gene Therapy Vs. Natural History In Patients With Leber Hereditary Optic Neuropathy Carrying The M.11778g>A Nd4 Mutation: Systematic Review And Indirect Comparison, Nancy J. Newman, Patrick Yu-Wai-Man, Valerio Carelli, Valerie Biousse, Mark Moster, Catherine Vignal-Clermont, Robert C. Sergott, Thomas Klopstock, Alfredo A. Sadun, Jean-François Girmens, Chiara La Morgia, Adam A. Debusk, Neringa Jurkute, Claudia Priglinger, Rustum Karanjia, Constant Josse, Julie Salzmann, François Montestruc, Michel Roux, Magali Taiel, José-Alain Sahel May 2021

Intravitreal Gene Therapy Vs. Natural History In Patients With Leber Hereditary Optic Neuropathy Carrying The M.11778g>A Nd4 Mutation: Systematic Review And Indirect Comparison, Nancy J. Newman, Patrick Yu-Wai-Man, Valerio Carelli, Valerie Biousse, Mark Moster, Catherine Vignal-Clermont, Robert C. Sergott, Thomas Klopstock, Alfredo A. Sadun, Jean-François Girmens, Chiara La Morgia, Adam A. Debusk, Neringa Jurkute, Claudia Priglinger, Rustum Karanjia, Constant Josse, Julie Salzmann, François Montestruc, Michel Roux, Magali Taiel, José-Alain Sahel

Wills Eye Hospital Papers

Objective: This work aimed to compare the evolution of visual outcomes in Leber hereditary optic neuropathy (LHON) patients treated with intravitreal gene therapy to the spontaneous evolution in prior natural history (NH) studies.

Design: A combined analysis of two phase three randomized, double-masked, sham-controlled studies (REVERSE and RESCUE) and their joint long-term extension trial (CLIN06) evaluated the efficacy of rAAV2/2-ND4 vs. 11 pooled NH studies used as an external control.

Subjects: The LHON subjects carried the m.11778G>A ND4 mutation and were aged ≥15 years at onset of vision loss.

Methods: A total of 76 subjects received a single …


Preparing Historically Underrepresented Trainees For Biomedical Cancer Research Careers At Huntsman Cancer Institute/University Of Utah Health., Ana Maria Lopez, Md, Mph, Macp, José E Rodríguez, Kathryn Browning Hawes, Anna Marsden, Don Ayer, Donna Harp Ziegenfuss, Kola Okuyemi May 2021

Preparing Historically Underrepresented Trainees For Biomedical Cancer Research Careers At Huntsman Cancer Institute/University Of Utah Health., Ana Maria Lopez, Md, Mph, Macp, José E Rodríguez, Kathryn Browning Hawes, Anna Marsden, Don Ayer, Donna Harp Ziegenfuss, Kola Okuyemi

Department of Medical Oncology Faculty Papers

Given the well-documented inequities in health care outcomes by race, ethnicity, and gender, many health career pipeline programs have focused on supporting the development of a diverse and inclusive workforce. The State of Utah, is vast, but sparsely populated outside the Salt Lake City metropolitan area. More than 96% of our nearly 85,000 square miles is designated rural (<100 people/square mile) or frontier (<7 people/square mile). The Salt Lake City area is home to the Hunsman Cancer Institute, the only NCI-designated Comprehensive Cancer Center in the region, also noted the limited diversity in the biomedical cancer research workforce. Our primary objective was to increase the number of underrepresented trainees who pursue higher education with the goal of a career in cancer research. PathMaker is a regional, competitive pipeline program that nurtures high school or undergraduate trainees from historically underrepresented backgrounds towards a career in cancer research. Our faculty and staff team collaboratively developed a cohort model curriculum that increased student awareness of research …


Reporting And Analyzing Race And Ethnicity In Orthopaedic Clinical Trials: A Systematic Review., Ryan W. Paul, Donghoon Lee, Joseph Brutico, Fotios P. Tjoumakaris, Michael G. Ciccotti, Kevin B, Freedman May 2021

Reporting And Analyzing Race And Ethnicity In Orthopaedic Clinical Trials: A Systematic Review., Ryan W. Paul, Donghoon Lee, Joseph Brutico, Fotios P. Tjoumakaris, Michael G. Ciccotti, Kevin B, Freedman

Rothman Institute Papers

BACKGROUND: The distinction between race and ethnicity should be carefully understood and described for demographic data collection. Racial healthcare differences have been observed across many orthopaedic subspecialties. However, the frequency of reporting and analyzing race and ethnicity in orthopaedic clinical trials has not been determined. Therefore, the primary purpose of this systematic review was to determine how frequently race and ethnicity are reported and analyzed in orthopaedic clinical trials.

METHODS: The top 10 journals by impact factor in the field of orthopaedics were manually screened from 2015 to 2019. All randomized controlled trials related to orthopaedics and assessing clinical outcomes …


Mapping The Little Brain At The Heart By An Interdisciplinary Systems Biology Team., Rajanikanth Vadigepalli, James S. Schwaber May 2021

Mapping The Little Brain At The Heart By An Interdisciplinary Systems Biology Team., Rajanikanth Vadigepalli, James S. Schwaber

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

No abstract provided.


Biomarkers Of Thrombo-Inflammatory Responses In Pulmonary Embolism Patients With Pre-Existing Versus New-Onset Atrial Fibrillation., Dimpi Patel, Amir Darki, Debra Hoppensteadt, Iman Darwish, Mushabbar Syed, Yevgeniy Brailovsky, Jawed Fareed May 2021

Biomarkers Of Thrombo-Inflammatory Responses In Pulmonary Embolism Patients With Pre-Existing Versus New-Onset Atrial Fibrillation., Dimpi Patel, Amir Darki, Debra Hoppensteadt, Iman Darwish, Mushabbar Syed, Yevgeniy Brailovsky, Jawed Fareed

Division of Cardiology Faculty Papers

Pulmonary embolism (PE) patients have an increased prevalence and incidence of atrial fibrillation (AF). Because comorbid AF increases risk of morbidity and mortality, we sought to investigate the role of thrombo-inflammatory biomarkers in risk stratifying patients who experience an acute PE episode. Study participants were enrolled from a Pulmonary Embolism Response Team (PERT) registry between March 2016 and March 2019 at Loyola University Medical Center and Gottlieb Memorial Hospital. This cohort was divided into 3 groups: PE patients with a prior diagnosis of AF (n = 8), PE patients with a subsequent diagnosis of AF (n = 11), and PE …


Radiologic Measurements In The Assessment Of Patellar Instability: A Systematic Review And Meta-Analysis., Alex E White, Peters T Otlans, Dylan P. Horan, Daniel Calem, William Emper, Kevin Freedman, Fotios Tjoumakaris, Md May 2021

Radiologic Measurements In The Assessment Of Patellar Instability: A Systematic Review And Meta-Analysis., Alex E White, Peters T Otlans, Dylan P. Horan, Daniel Calem, William Emper, Kevin Freedman, Fotios Tjoumakaris, Md

Rothman Institute Papers

Background: Numerous diagnostic imaging measurements related to patellar instability have been evaluated in the literature; however, little has been done to compare these findings across multiple studies.

Purpose: To review the different imaging measurements used to evaluate patellar instability and to assess the prevalence of each measure and its utility in predicting instability. We focused on reliability across imaging modalities and between patients with and without patellar instability.

Study Design: Systematic review; Level of evidence, 4.

Methods: We performed a systematic review of the literature using the PubMed, SCOPUS, and Cochrane databases. Each database was searched for variations of the …


A Randomized Trial To Improve Adherence To Follow-Up Eye Examinations Among People With Glaucoma, Benjamin E Leiby, Sarah E. Hegarty, Tingting Zhan, Jonathan S Myers, L Jay Katz, Julia A Haller, Michael Waisbourd, Christine Burns, Meskerem Divers, Jeanne Molineaux, Jeffrey Henderer, Charles Brodowski, Lisa A Hark May 2021

A Randomized Trial To Improve Adherence To Follow-Up Eye Examinations Among People With Glaucoma, Benjamin E Leiby, Sarah E. Hegarty, Tingting Zhan, Jonathan S Myers, L Jay Katz, Julia A Haller, Michael Waisbourd, Christine Burns, Meskerem Divers, Jeanne Molineaux, Jeffrey Henderer, Charles Brodowski, Lisa A Hark

Department of Pharmacology and Experimental Therapeutics Faculty Papers

INTRODUCTION: Appointment nonadherence is common among people with glaucoma, making it difficult for eye care providers to monitor glaucoma progression. Our objective was to determine whether the use of patient navigators, in conjunction with social worker support, could increase adherence to recommended follow-up eye appointments.

METHODS: A randomized, controlled trial evaluated the effectiveness of an intervention that used patient navigators and social workers to improve patient adherence to follow-up eye care compared with usual care. Participants with glaucoma and other eye diseases (N = 344) were identified at primary care clinics in community settings through telemedicine screening of imaging and …


Resistance To Lethal Ectromelia Virus Infection Requires Type I Interferon Receptor In Natural Killer Cells And Monocytes But Not In Adaptive Immune Or Parenchymal Cells., Carolina R Melo-Silva, Pedro Alves-Peixoto, Natasha Heath, Lingjuan Tang, Brian Montoya, Cory J Knudson, Colby Stotesbury, Maria Ferez, Eric B. Wong, Luis J. Sigal May 2021

Resistance To Lethal Ectromelia Virus Infection Requires Type I Interferon Receptor In Natural Killer Cells And Monocytes But Not In Adaptive Immune Or Parenchymal Cells., Carolina R Melo-Silva, Pedro Alves-Peixoto, Natasha Heath, Lingjuan Tang, Brian Montoya, Cory J Knudson, Colby Stotesbury, Maria Ferez, Eric B. Wong, Luis J. Sigal

Department of Microbiology and Immunology Faculty Papers

Type I interferons (IFN-I) are antiviral cytokines that signal through the ubiquitous IFN-I receptor (IFNAR). Following footpad infection with ectromelia virus (ECTV), a mouse-specific pathogen, C57BL/6 (B6) mice survive without disease, while B6 mice broadly deficient in IFNAR succumb rapidly. We now show that for survival to ECTV, only hematopoietic cells require IFNAR expression. Survival to ECTV specifically requires IFNAR in both natural killer (NK) cells and monocytes. However, intrinsic IFNAR signaling is not essential for adaptive immune cell responses or to directly protect non-hematopoietic cells such as hepatocytes, which are principal ECTV targets. Mechanistically, IFNAR-deficient NK cells have reduced …


Mircorrnet: Machine Learning-Based Integration Of Mirna And Mrna Expression Profiles, Combined With Feature Grouping And Ranking., Malik Yousef, Gokhan Goy, Ramkrishna Mitra, Christine M. Eischen, Amhar Jabeer, Burcu Bakir-Gungor May 2021

Mircorrnet: Machine Learning-Based Integration Of Mirna And Mrna Expression Profiles, Combined With Feature Grouping And Ranking., Malik Yousef, Gokhan Goy, Ramkrishna Mitra, Christine M. Eischen, Amhar Jabeer, Burcu Bakir-Gungor

Department of Cancer Biology Faculty Papers

A better understanding of disease development and progression mechanisms at the molecular level is critical both for the diagnosis of a disease and for the development of therapeutic approaches. The advancements in high throughput technologies allowed to generate mRNA and microRNA (miRNA) expression profiles; and the integrative analysis of these profiles allowed to uncover the functional effects of RNA expression in complex diseases, such as cancer. Several researches attempt to integrate miRNA and mRNA expression profiles using statistical methods such as Pearson correlation, and then combine it with enrichment analysis. In this study, we developed a novel tool called miRcorrNet, …


Nicotine Aggravates Vascular Adiponectin Resistance Via Ubiquitin-Mediated Adiponectin Receptor Degradation In Diabetic Apolipoprotein E Knockout Mouse, Jia Gao, Jianghong Fan, Zhijun Meng, Rui Wang, Caihong Liu, Jing Liu, Bin Liang, Jing Wang, Yaoli Xie, Jing Zhao, Rui Guo, Jianli Zhao, Xin-Liang Ma, Xiangying Jiao, Jimin Cao, Yajing Wang May 2021

Nicotine Aggravates Vascular Adiponectin Resistance Via Ubiquitin-Mediated Adiponectin Receptor Degradation In Diabetic Apolipoprotein E Knockout Mouse, Jia Gao, Jianghong Fan, Zhijun Meng, Rui Wang, Caihong Liu, Jing Liu, Bin Liang, Jing Wang, Yaoli Xie, Jing Zhao, Rui Guo, Jianli Zhao, Xin-Liang Ma, Xiangying Jiao, Jimin Cao, Yajing Wang

Department of Emergency Medicine Faculty Papers

There is limited and discordant evidence on the role of nicotine in diabetic vascular disease. Exacerbated endothelial cell dysregulation in smokers with diabetes is associated with the disrupted adipose function. Adipokines possess vascular protective, anti-inflammatory, and anti-diabetic properties. However, whether and how nicotine primes and aggravates diabetic vascular disorders remain uncertain. In this study, we evaluated the alteration of adiponectin (APN) level in high-fat diet (HFD) mice with nicotine (NIC) administration. The vascular pathophysiological response was evaluated with vascular ring assay. Confocal and co-immunoprecipitation analysis were applied to identify the signal interaction and transduction. These results indicated that the circulating …


Differences In Nt-Probnp Response And Prognosis In Men And Women With Heart Failure With Reduced Ejection Fraction., Melissa A Daubert, Eric Yow, Huiman X Barnhart, Ileana L Piña, Tariq Ahmad, Eric Leifer, Lawton Cooper, Patrice Desvigne-Nickens, Mona Fiuzat, Kirkwood Adams, Justin Ezekowitz, David J Whellan, James L Januzzi, Christopher M O'Connor, G Michael Felker May 2021

Differences In Nt-Probnp Response And Prognosis In Men And Women With Heart Failure With Reduced Ejection Fraction., Melissa A Daubert, Eric Yow, Huiman X Barnhart, Ileana L Piña, Tariq Ahmad, Eric Leifer, Lawton Cooper, Patrice Desvigne-Nickens, Mona Fiuzat, Kirkwood Adams, Justin Ezekowitz, David J Whellan, James L Januzzi, Christopher M O'Connor, G Michael Felker

Division of Cardiology Faculty Papers

Background NT-proBNP (N-terminal pro-B-type natriuretic peptide) is a prognostic biomarker in heart failure (HF) with reduced ejection fraction. However, it is unclear whether there is a sex difference in NT-proBNP response and whether the therapeutic goal of NT-proBNP ≤1000 pg/mL has equivalent prognostic value in men and women with HF with reduced ejection fraction. Methods and Results In a secondary analysis of the GUIDE-IT (Guiding Evidence Based Therapy Using Biomarker Intensified Treatment) trial we analyzed trends in NT-proBNP and goal attainment by sex. Differences in clinical characteristics, HF treatment, and time to all-cause death or HF hospitalization were compared. Landmark …


Efficacy Of Half-Day Workshops For Internal Medicine Interns In Educating Breaking-Bad-News Discussions, Colin Thomas, Christine Kurian, Sarah Houtmann, Neil D. Palmisiano May 2021

Efficacy Of Half-Day Workshops For Internal Medicine Interns In Educating Breaking-Bad-News Discussions, Colin Thomas, Christine Kurian, Sarah Houtmann, Neil D. Palmisiano

Division of Internal Medicine Faculty Papers & Presentations

Background: Adequate end-of-life (EOL) care/breaking-bad-news (BBN) discussions with patients are becoming increasingly essential to adequate patient care. Purpose: Whether a half-day workshop would lead to improved confidence in EOL/BBN care discussions for internal medicine interns. Methods: Internal medicine interns (n = 43) were assigned to participate in a half-day workshop at Thomas Jefferson University Hospital. The workshop involved two standardized patient (SP) interactions involving delivering news of a terminal illness/initiating goals of care discussion with the intervention of SP feedback, a didactic and lecture on proper EOL/BBN discussion. Voluntary anonymous surveys before and after the workshop were utilized to …


Long Term Safety, Tolerability, And Efficacy Of Intracutaneous Zolmitriptan (M207) In The Acute Treatment Of Migraine., Stephanie J. Nahas, Nada Hindiyeh, Deborah I. Friedman, Nada Elbuluk, Donald J. Kellerman, Pamela K. Foreman, Peter Schmidt May 2021

Long Term Safety, Tolerability, And Efficacy Of Intracutaneous Zolmitriptan (M207) In The Acute Treatment Of Migraine., Stephanie J. Nahas, Nada Hindiyeh, Deborah I. Friedman, Nada Elbuluk, Donald J. Kellerman, Pamela K. Foreman, Peter Schmidt

Department of Neurology Faculty Papers

OBJECTIVE: To determine the long-term safety and tolerability profile of M207 in the acute treatment of migraine.

BACKGROUND: M207 is an investigational microneedle-based system for intracutaneous delivery of zolmitriptan for the treatment of migraine attacks. Following on the positive results of a Phase 2/3 placebo-controlled efficacy study (ZOTRIP), this study was designed to evaluate the safety of this novel product during repeated use for the treatment of migraine attacks.

METHODS: In this 6-12 month open-label, multicenter observational study, participants used an eDiary to record headache symptoms and adverse events at specified intervals up to 48 h following treatment of a …


Seeking Truer Measures Of Success: Moving Toward More Rigorous Evaluations Of Industry-Led Access To Medicines Programs., Cherie Lynn Ramirez, Ashveena Gajeelee, Brianna Desharnais, Jenna Sherman, Dexter Waters May 2021

Seeking Truer Measures Of Success: Moving Toward More Rigorous Evaluations Of Industry-Led Access To Medicines Programs., Cherie Lynn Ramirez, Ashveena Gajeelee, Brianna Desharnais, Jenna Sherman, Dexter Waters

Student Papers, Posters & Projects

No abstract provided.


Automated Assessment Of Thoracic-Abdominal Asynchrony In Patients With Morquio Syndrome., Madhavi V Ratnagiri, Yan Zhu, Tariq Rahman, Mary Theroux, Shunji Tomatsu, Thomas H Shaffer May 2021

Automated Assessment Of Thoracic-Abdominal Asynchrony In Patients With Morquio Syndrome., Madhavi V Ratnagiri, Yan Zhu, Tariq Rahman, Mary Theroux, Shunji Tomatsu, Thomas H Shaffer

Department of Pediatrics Faculty Papers

Morquio syndrome is a rare disease caused by a disorder in the storage of mucopolysaccharides that affects multiple organs, including musculoskeletal, respiratory, cardiovascular, and digestive systems. Respiratory failure is one of the leading causes of mortality in Morquio patients; thus, respiratory function testing is vital to the management of the disease. An automated respiratory assessment methodology using the pneuRIP device and a machine-learning algorithm was developed. pneuRIP is a noninvasive approach that uses differences between thoracic and abdominal movements (thoracic-abdominal asynchrony) during respiration to assess respiratory status. The technique was evaluated on 17 patients with Morquio (9 females and 8 …


Mindset, Medicine And You, Gregory A. Jaffe, Md, Msed May 2021

Mindset, Medicine And You, Gregory A. Jaffe, Md, Msed

Department of Family & Community Medicine Presentations and Grand Rounds

Objectives

  • Describe the differences between a fixed and growth mindset
  • State phrases that encourage growth mindset
  • Apply growth mindset techniques to medical education


When Total Joint Arthroplasty After Septic Arthritis Can Be Safely Performed, Timothy L. Tan, Chi Xu, Feng-Chih Kuo, Elie Ghanem, Jaiben George, Noam Shohat, Ji-Ying Chen, Mel S Lee, Carlos Higuera, Javad Parvizi May 2021

When Total Joint Arthroplasty After Septic Arthritis Can Be Safely Performed, Timothy L. Tan, Chi Xu, Feng-Chih Kuo, Elie Ghanem, Jaiben George, Noam Shohat, Ji-Ying Chen, Mel S Lee, Carlos Higuera, Javad Parvizi

Rothman Institute Papers

Background: Patients undergoing total joint arthroplasty (TJA) following septic arthritis are at higher risk for developing periprosthetic joint infection (PJI). Minimal literature is available to guide surgeons on the optimal timing of TJA after completing treatment for prior native joint septic arthritis. This multicenter study aimed to determine the optimal timing of TJA after prior septic arthritis and to examine the role of preoperative serology in predicting patients at risk for developing PJI.

Methods: A total of 207 TJAs were performed after prior septic arthritis from 2000 to 2017 at 5 institutions. Laboratory values, prior treatment, time from the initial …