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Articles 13381 - 13410 of 14899
Full-Text Articles in Medicine and Health Sciences
Botulinum Toxin Type A In The Prophylactic Treatment Of Chronic Tension-Type Headache: A Multicentre, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study, Stephen D. Silberstein, H. Göbel, R. Jensen, A. H. Elkind, R. Degryse, J. M.C.M. Walcott, C. Turkel
Botulinum Toxin Type A In The Prophylactic Treatment Of Chronic Tension-Type Headache: A Multicentre, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study, Stephen D. Silberstein, H. Göbel, R. Jensen, A. H. Elkind, R. Degryse, J. M.C.M. Walcott, C. Turkel
Department of Neurology Faculty Papers
We studied the safety and efficacy of 0 U, 50 U, 100 U, 150 U (five sites), 86 Usub and 100 Usub (three sites) botulinum toxin type A (BoNTA; BOTOX); Allergan, Inc., Irvine, CA, USA) for the prophylaxis of chronic tension-type headache (CTTH). Three hundred patients (62.3% female; mean age 42.6 years) enrolled. For the primary endpoint, the mean change from baseline in the number of TTH-free days per month, there was no statistically significant difference between placebo and four BoNTA groups, but a significant difference favouring placebo vs. BoNTA 150 was observed (4.5 vs. 2.8 tension headache-free days/month; P …
Jefferson Alumni Bulletin – Volume 55, Number 2, Summer 2006
Jefferson Alumni Bulletin – Volume 55, Number 2, Summer 2006
The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)
Jefferson Alumni Bulletin – Volume 55, Number 2, Summer 2006 Dean’s Column: A Complex Undertaking; Page 3 Construction Begins on Innovative Breast Care Center; Page 4 Clues to How Molecular Gatekeepers Work; Page 5 A Tie Between Obesity and Alzheimer’s Disease; Page 6 Fighting Artificial Implant Infections; Page 7 Reducing Radiation’s Side Effects; Page 8 Developing a New Vascular Bypass Graft; Page 8 On Campus: Dicker to Direct Translational Research Program; Page 9 Parents Day; Page 12 Class Notes; Page 13 Swatl Shah, MD’95 Rebuilds After Katrina; Page 19 Match Day 2006; Page 23 Special Center Section: Alumni Weekend
Antioxidant Enzyme Gene Delivery To Protect From Hiv-1 Gp120-Induced Neuronal Apoptosis, Lokesh Agrawal, Jean-Pierre Louboutin, Beverly A.S. Reyes, Elisabeth J. Van Bockstaele, David S. Strayer
Antioxidant Enzyme Gene Delivery To Protect From Hiv-1 Gp120-Induced Neuronal Apoptosis, Lokesh Agrawal, Jean-Pierre Louboutin, Beverly A.S. Reyes, Elisabeth J. Van Bockstaele, David S. Strayer
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Human immunodeficiency virus-1 (HIV-1) infection in the central nervous system (CNS) may lead to neuronal loss and progressively deteriorating CNS function: HIV-1 gene products, especially gp120, induce free radical-mediated apoptosis. Reactive oxygen species (ROS), are among the potential mediators of these effects. Neurons readily form ROS after gp120 exposure, and so might be protected from ROS-mediated injury by antioxidant enzymes such as Cu/Zn-superoxide dismutase (SOD1) and/or glutathione peroxidase (GPx1). Both enzymes detoxify oxygen free radicals. Because they are highly efficient gene delivery vehicles for neurons, recombinant SV40-derived vectors were used for these studies. Cultured mature neurons derived from NT2 cells …
Quantifying Gene Network Connectivity In Silico: Scalability And Accuracy Of A Modular Approach, Nirupama Yalamanchili, Daniel E. Zak, Babatunde A. Ogunnaike, James S. Schwaber, Andres Kriete, Boris N. Kholodenko
Quantifying Gene Network Connectivity In Silico: Scalability And Accuracy Of A Modular Approach, Nirupama Yalamanchili, Daniel E. Zak, Babatunde A. Ogunnaike, James S. Schwaber, Andres Kriete, Boris N. Kholodenko
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Large, complex data sets that are generated from microarray experiments, create a need for systematic analysis techniques to unravel the underlying connectivity of gene regulatory networks. A modular approach, previously proposed by Kholodenko and co-workers, helps to scale down the network complexity into more computationally manageable entities called modules. A functional module includes a gene's mRNA, promoter and resulting products, thus encompassing a large set of interacting states. The essential elements of this approach are described in detail for a three-gene model network and later extended to a ten-gene model network, demonstrating scalability. The network architecture is identified by analysing …
Comparison Of Dynamic (Brush) And Static (Pressure) Mechanical Allodynia In Migraine, C. Lopinto, W. B. Young, Avi Ashkenazi
Comparison Of Dynamic (Brush) And Static (Pressure) Mechanical Allodynia In Migraine, C. Lopinto, W. B. Young, Avi Ashkenazi
Department of Neurology Faculty Papers
Allodynia has been described in migraine but has not been fully investigated for the different sensory modalities. The aim of this study was to compare the prevalence of dynamic (brush) and static (pressure) mechanical allodynia in migraine patients and to suggest a practical method of testing them in a clinical setting. Patients with International Headache Society-defined episodic migraine (EM) or with transformed migraine (TM) as defined by Silberstein and Lipton were prospectively recruited from the Jefferson Headache Center out-patient clinic. A questionnaire of migraine features and symptoms of allodynia was administered. Brush allodynia (BA) was tested by cutaneous stimulation with …
Ahrq Action
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
New Senior Scholars
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
Department Publications And Presentations
Department Publications And Presentations
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
Health Policy Forum: Fall 2006
Health Policy Forum: Fall 2006
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
The 15th Annual Grandon Lecture: Improving Ambulatory Care, Joshua Gagne
The 15th Annual Grandon Lecture: Improving Ambulatory Care, Joshua Gagne
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
Considering "Faculty Priorities Reconsidered", Sara L. Thier, Kenneth D, Smith
Considering "Faculty Priorities Reconsidered", Sara L. Thier, Kenneth D, Smith
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
Whyy Seeks Guidance From Healthcare And Community Leaders, Sara L. Thier
Whyy Seeks Guidance From Healthcare And Community Leaders, Sara L. Thier
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
The Einstein-La Salle Nursing Careers Partnership Program, Mary Beth Kingston, Etienne Phipps
The Einstein-La Salle Nursing Careers Partnership Program, Mary Beth Kingston, Etienne Phipps
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
Letters To The Editor
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
Cms Rehabilitation Policy: Expediency Vs. Rationality, Douglas M. Elwood, Jonathon S. Kirschner, John L. Melvin
Cms Rehabilitation Policy: Expediency Vs. Rationality, Douglas M. Elwood, Jonathon S. Kirschner, John L. Melvin
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
Medicare's Roadmap, David B. Nash
Medicare's Roadmap, David B. Nash
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
Systems Analysis Of Circadian Time-Dependent Neuronal Epidermal Growth Factor Receptor Signaling, Daniel E. Zak, Haiping Hao, Rajanikanth Vadigepalli, Gregory M. Miller, Babatunde A. Ogunnaike, James S. Schwaber
Systems Analysis Of Circadian Time-Dependent Neuronal Epidermal Growth Factor Receptor Signaling, Daniel E. Zak, Haiping Hao, Rajanikanth Vadigepalli, Gregory M. Miller, Babatunde A. Ogunnaike, James S. Schwaber
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Background
Identifying the gene regulatory networks governing physiological signal integration remains an important challenge in circadian biology. Epidermal growth factor receptor (EGFR) has been implicated in circadian function and is expressed in the suprachiasmatic nuclei (SCN), the core circadian pacemaker. The transcription networks downstream of EGFR in the SCN are unknown but, by analogy to other SCN inputs, we expect the response to EGFR activation to depend on circadian timing.
Results
We have undertaken a systems-level analysis of EGFR circadian time-dependent signaling in the SCN. We collected gene-expression profiles to study how the SCN response to EGFR activation depends on …
Systems Analysis Of Circadian Time-Dependent Neuronal Epidermal Growth Factor Receptor Signaling, Daniel E. Zak, Haiping Hao, Rajanikanth Vadigepalli, Gregory M. Miller, Babatunde A. Ogunnaike, James S. Schwaber
Systems Analysis Of Circadian Time-Dependent Neuronal Epidermal Growth Factor Receptor Signaling, Daniel E. Zak, Haiping Hao, Rajanikanth Vadigepalli, Gregory M. Miller, Babatunde A. Ogunnaike, James S. Schwaber
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Background
Identifying the gene regulatory networks governing physiological signal integration remains an important challenge in circadian biology. Epidermal growth factor receptor (EGFR) has been implicated in circadian function and is expressed in the suprachiasmatic nuclei (SCN), the core circadian pacemaker. The transcription networks downstream of EGFR in the SCN are unknown but, by analogy to other SCN inputs, we expect the response to EGFR activation to depend on circadian timing.
Results
We have undertaken a systems-level analysis of EGFR circadian time-dependent signaling in the SCN. We collected gene-expression profiles to study how the SCN response to EGFR activation depends on …
Health Policy Forum Speakers
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
Welcome To Alexis Skoufalos, Edd
Welcome To Alexis Skoufalos, Edd
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
Two New Department Books Published
Two New Department Books Published
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
New Senior Scholars
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
Disease Management Colloquium
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
Navigating Medicare Part D:A Personal Experience With The New Medicare Prescription Drug Benefit, Daniel Z. Louis
Navigating Medicare Part D:A Personal Experience With The New Medicare Prescription Drug Benefit, Daniel Z. Louis
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
New Publications From The Department Of Health Policy
New Publications From The Department Of Health Policy
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
Interclerkship Day 2006: Improving Patient Safety: Paul Barach, Paul Barach
Interclerkship Day 2006: Improving Patient Safety: Paul Barach, Paul Barach
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
Interclerkship Day 2006: Improving Patient Safety: John J. Nance, John J. Nance
Interclerkship Day 2006: Improving Patient Safety: John J. Nance, John J. Nance
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
Interclerkship Day 2006: Improving Patient Safety: Judith Owens, Judith Owens
Interclerkship Day 2006: Improving Patient Safety: Judith Owens, Judith Owens
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
The Institute For Healthcare Improvement’S 100,000 Lives Campaign , Kristy Alvarez, Christopher N. Sciamanna
The Institute For Healthcare Improvement’S 100,000 Lives Campaign , Kristy Alvarez, Christopher N. Sciamanna
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.
Letters To The Editor
Population Health Matters (Formerly Health Policy Newsletter)
No abstract provided.