Medicine and Health Sciences Commons^™

Redefining Healthcare Education: Perspectives And Accomplishments, Brian G. Harrison, Robert L. Barchi

Thomas Jefferson University Administrative Documents and Reports

2007 Annual report of Thomas Jefferson University.

Download Full Pdf Issue Of Thomas Jefferson University Mph Public Health Link Newsletter, Vol. 3, Iss. 6, July 2007

Public Health Link

This issue includes an article written by Dr. James Plumb on "Public Health Perspective: Linking Public Health and Medical Education at Jefferson" along with thesis presenters and other program announcements.

Autocrine Prolactin Promotes Prostate Cancer Cell Growth Via Janus Kinase-2-Signal Transducer And Activator Of Transcription-5a/B Signaling Pathway., Ayush Dagvadorj, Sean Collins, Jean-Baptiste Jomain, Junaid Abdulghani, James Karras, Tobias Zellweger, Hongzhen Li, Martti Nurmi, Kalle Alanen, Tuomas Mirtti, Tapio Visakorpi, Lukas Bubendorf, Vincent Goffin, Marja T Nevalainen

Department of Cancer Biology Faculty Papers

The molecular mechanisms that promote progression of localized prostate cancer to hormone-refractory and disseminated disease are poorly understood. Prolactin (Prl) is a local growth factor produced in high-grade prostate cancer, and exogenously added Prl in tissue or explant cultures of normal and malignant prostate is a strong mitogen and survival factor for prostate epithelium. The key signaling proteins that mediate the biological effects of Prl in prostate cancer are Signal Transducer and Activator of Transcription (Stat)-5a/5b via activation of Janus kinase-2. Importantly, inhibition of Stat5a/b in prostate cancer cells induces apoptotic death. Using a specific Prl receptor antagonist (Delta1-9G129R-hPRL), we …

Jefferson Alumni Bulletin – Volume 56, Number 3, Summer 2007

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume 56, Number 3, Summer 2007

Dean’s Column: Estrangement; Page 2

Findings: Targeting Adrenal Gland Could Be Key Strategy Against Heart Failure, Rabies-based Vaccine Could Be Effective Against HIV; Page 6

On Campus; Page 8

Tackling the Tough Questions; Page 11

How Microscopic is Microscopic Anatomy? Page 20

Class Notes; Page 22

In Memoriam; Page 24

Match Day; Page 26

By The Numbers; Match Day; Page 29

Resected Serous Cystic Neoplasms Of The Pancreas: Locally Aggressive Behavior As A Predictor Of Malignant Disease? A Review Of 158 Patients With Recommendations For Treatment., Charles Galanis, Amir Zamani, John L. Cameron, Kurtis A. Campbell, Keith D. Lillemoe, David Caparrelli, David Chang, Ralph H. Hruban, Charles Yeo

Department of Surgery Faculty Papers

Background: Serous cystic neoplasms of the pancreas are regarded as a benign entity with rare malignant potential. Surgical resection is generally considered curative. Objective: To perform the largest single institution review of patients who underwent surgical resection for serous cystic neoplasms of the pancreas in the hopes of guiding future management. Methods: Between June 1988 and January 2005, 158 patients with serous cystic neoplasms of the pancreas underwent surgical resection. A retrospective analysis was performed. Univariate and multivariate models were used to determine factors influencing perioperative morbidity and mortality. Major complications were defined as pancreatic fistula or anastomotic leak, postoperative …

Gangliocytic Paraganglioma: Case Report And Review Of The Literature, Agnes Witkiewicz, Avi Galler, Charles Yeo

Department of Surgery Faculty Papers

Gangliocytic paraganglioma is a rare tumor, which occurs nearly exclusively in the second portion of the duodenum. Generally, this tumor has a benign clinical course, although rarely, it may recur or metastasize to regional lymph nodes. Only one case with distant metastasis has been reported. We present a case of duodenal gangliocytic paraganglioma treated first by local resection followed by pylorus-preserving pancreaticoduodenectomy. Examination of the first specimen revealed focal nuclear pleomorphism and mitotic activity, in addition to the presence of three characteristic histologic components: epithelioid, ganglion, and spindle cell. In the subsequent pancreaticoduodenectomy specimen, there was no residual tumor identified …

Relationships Between Scores On The Jefferson Scale Of Physician Empathy, Patient Perceptions Of Physician Empathy, And Humanistic Approaches To Patient Care: A Validity Study., Karen M. Glaser, Fred W. Markham, Herbert M. Adler, Patrick R. Mcmanus, Mohammadreza Hojat

Department of Psychiatry and Human Behavior Faculty Papers

BACKGROUND: Empathy is the backbone of a positive physician-patient relationship. Physician empathy and the patient's awareness of the physician's empathic concern can lead to a more positive clinical outcome.

MATERIAL/METHODS: The Jefferson Scale of Physician Empathy (JSPE) was completed by 36 physicians in the Family Medicine residency program at Thomas Jefferson University Hospital, and 90 patients evaluated these physicians by completing the Jefferson Scale of Patient Perceptions of Physician Empathy (JSPPPE), and a survey about physicians' humanistic approaches to patient care.

RESULTS: A statistically significant correlation was found between scores of the JSPE and JSPPPE (r=0.48, p

CONCLUSIONS: These findings …

Allergic Contact Dermatitis From Tea Tree Oil

Department of Family & Community Medicine Faculty Papers

The sudden appearance of a pruritic confluent erythematous rash on the anterior neck and upper back prompted a 30-year-old woman to seek medical attention. She had recently started applying 5% tea tree oil to the area to treat chronic, recurrent tinea versicolor. An herbal specialist had recommended this therapy.

Benefits College Update

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

New Publications And Presentations From The Department Of Health Policy

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Transforming Healthcare: Themes From The 5th Annual National Md/Mba Conference, Jeff Clough '08, Eric Moskowitz '09

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Thomas Jefferson And Widener Universities Announce Joint Degree Program In Law And Public Health

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Rx For Pennsylvania July 17, 2007

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Potential Impact Of Advance Directive Law Act 169 On Decisions And Care For Patients At End Of Life: Reflections Of Ethics Consultants, Etienne Phipps, Phd, Richard Allman, Md

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Patient Safety: The Impact Of Facilty Design

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Domestic Violence In Same-Sex Couples, Robert J. Winn, Md, Katie Kupfer Lockwood '08, Ralph Riviello, Md

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

A Study Of Colorectal Cancer Screening In Pennsylvania, Ronald E. Myers, Phd, Mona Sarfaty, Md

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Update On Screening For Colorectal Cancer, Mona Sarfaty, Md

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Welcome The 2007-2008 Delaware Valley Schweitzer Fellows

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Letters To The Editor

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Welcome To Our Newest Senior Scholars!

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Activating Patient Involvement, Kevin Bowman, Md, David B. Nash, Md, Mba

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Treatment Of Kawasaki Disease, Andrea Taddio, Carlos D. Rosé

Department of Pediatrics Faculty Papers

No abstract provided.

Quality Of Care Measures For Migraine: A Comprehensive Review, Joshua J. Gagne, Brian Leas, Jennifer H. Lofland, Neil Goldfarb, Frederick Freitag, Stephen Silberstein

College of Population Health Faculty Papers

Migraine headache is a highly prevalent, chronic, episodic disorder that is associated with high direct and indirect costs. Migraine headache impacts not only patients, but also their employers due to substantial decreases in workplace productivity. Despite the prevalence and clinical and economic burdens of migraine, no national efforts to develop and implement standardized measures of quality of care have been made. The objective of this study was to collect and report on existing quality of care measures for migraine that could be suitable for quality measurement at the health-plan level. Published literature, the Agency for Healthcare Research and Quality's National …

Meeting Report: The Role Of Environmental Lighting And Circadian Disruption In Cancer And Other Diseases, Richard G. Stevens, David E. Blask, George C. Brainard, Johnni Hansen, Steven W. Lockley, Ignacio Provencio, Mark S. Rea, Leslie Reinlib

Department of Neurology Faculty Papers

Light, including artificial light, has a range of effects on human physiology and behavior and can therefore alter human physiology when inappropriately timed. One example of potential light-induced disruption is the effect of light on circadian organization, including the production of several hormone rhythms. Changes in light-dark exposure (e.g., by nonday occupation or transmeridian travel) shift the timing of the circadian system such that internal rhythms can become desynchronized from both the external environment and internally with each other, impairing our ability to sleep and wake at the appropriate times and compromising physiologic and metabolic processes. Light can also have …

Comparison Of Contrast Enhanced Color Doppler Targeted Biopsy To Conventional Systematic Biology: Impact On Gleason Score, M. Mitterberger, G. M. Pinggera, W. Horninger, G. Bartsch, H. Strasser, G. Schafer, A. Brunner, Ethan J. Halpern, J. Gradl, L. Pallwein, F. Frauscher

Department of Radiology Faculty Papers

Purpose: Prostate cancer grading with Gleason score is an important prognostic factor. This prospective randomized study compares ultrasound systematic biopsy vs contrast enhanced color Doppler targeted biopsy for the impact on Gleason score findings.

Materials and Methods: We examined 690 men (mean age 56 years, range 41 to 77) with a serum total prostate specific antigen of 1.25 ng/ml or greater, a free-to-total prostate specific antigen ratio less than 18% and/or a suspicious digital rectal examination. Contrast enhanced color Doppler targeted biopsies with a limited number of cores (5 or less) were performed in hypervascular areas of the peripheral zone …

Download Full Pdf Issue Of Thomas Jefferson University Mph Public Health Link Newsletter, Vol. 3, Iss. 5, June 2007

Public Health Link

This issue highlights the newly created joint public health and law programs between Thomas Jefferson University and Widener University as well as an article written by Dr. James Plumb on poverty reduction and health.

Acute Myocardial Infarction In Systemic Sclerosis Patients: A Case Series, Chris T. Derk, Sergio A. Jimenez

Department of Medicine Faculty Papers

To characterize the clinical manifestations of patients with systemic sclerosis who develop a myocardial infarction (MI), a retrospective review of the medical records of all patients who were admitted to our institution between 1982 and 2002 and had the dual diagnosis of systemic sclerosis and an acute MI was done. From 1,009 systemic sclerosis hospital admissions, 11 (1.09%) were for an acute MI. Three of these patients had normal coronaries, and instead of wall motion abnormalities, left ventricular hypertrophy was the predominant finding of an echocardiography. The odds ratio of finding normal coronaries in systemic sclerosis vs the general population …

The Pharmacokinetics Of Taurolidine Metabolites In Healthy Volunteers., Li Gong, Howard E Greenberg, James L Perhach, Scott A Waldman, Walter K. Kraft

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Taurolidine is an experimental antibacterial and antiendotoxic compound whose clinical utility as an antitumor agent is being investigated in human clinical trials. Taurolidine in aqueous solution exists in equilibrium with taurultam. Taurultam is subsequently transformed to taurinamide. The pharmacokinetic profiles of these metabolites are not well established. In this study, 18 healthy volunteers were administered 5.0 g of taurolidine in 250 mL of 5% polyvinylpyrrolidone in water over 2, 1, or 0.5 hours by intravenous infusion in a parallel-group design. All subjects noted discomfort at the infusion site, although there were no serious adverse events. t(max) generally occurred at the …

Adiponectin Deficiency Increases Leukocyte-Endothelium Interactions Via Upregulation Of Endothelial Cell Adhesion Molecules In Vivo, Raogo Ouedraogo, Yulan Gong, Brett Berzins, Xiandong Wu, Kalyankar Mahadev, Kelly Hough, Lawrence Chan, Barry J. Goldstein, Rosario Scalia

Department of Medicine Faculty Papers

This study reports on what we believe are novel mechanism(s) of the vascular protective action of adiponectin. We used intravital microscopy to measure leukocyte-endothelium interactions in adiponectin-deficient (Ad^–/–) mice and found that adiponectin deficiency was associated with a 2-fold increase in leukocyte rolling and a 5-fold increase in leukocyte adhesion in the microcirculation. Measurement of endothelial NO (eNO) revealed that adiponectin deficiency drastically reduced levels of eNO in the vascular wall. Immunohistochemistry demonstrated increased expression of E-selectin and VCAM-1 in the vascular endothelium of Ad^–/– mice. Systemic administration of the recombinant globular adiponectin domain (gAd) to Ad …