Medicine and Health Sciences Commons^™

Optimal Technical Management Of Stump Closure Following Distal Pancreatectomy: A Retrospective Review Of 215 Cases., Lisa J. Harris, Hamid Abdollahi, Timothy Newhook, Patricia K. Sauter, Albert G. Crawford, Karen A. Chojnacki, Ernest L. Rosato, Eugene P. Kennedy, Charles J. Yeo, Adam C. Berger

Department of Surgery Faculty Papers

BACKGROUND: Pancreatic fistula (PF) is a major source of morbidity following distal pancreatectomy (DP). Our aim was to identify risk factors related to PF following DP and to determine the impact of technique of transection and stump closure.

METHODS: We performed a retrospective review of 215 consecutive patients who underwent DP. Perioperative and postoperative data were collected and analyzed with attention to PF as defined by the International Study Group of Pancreatic Fistula.

RESULTS: PF developed in 36 patients (16.7%); fistulas were classified as Grade A (44.4%), B (44.4%), or C (11.1%). The pancreas was transected with stapler (n = …

Comparison Of Ge Centricity Electronic Medical Record Database And National Ambulatory Medical Care Survey Findings On The Prevalence Of Major Conditions In The United States., Albert G. Crawford, Christine Cote, Joseph Couto, Mehmet Daskiran, Candace Gunnarsson, Kara Haas, Sara Haas, Somesh C Nigam, Rob Schuette, Joseph Yaskin

College of Population Health Faculty Papers

The study objective was to facilitate investigations by assessing the external validity and generalizability of the Centricity Electronic Medical Record (EMR) database and analytical results to the US population using the National Ambulatory Medical Care Survey (NAMCS) data and results as an appropriate validation resource. Demographic and diagnostic data from the NAMCS were compared to similar data from the Centricity EMR database, and the impact of the different methods of data collection was analyzed. Compared to NAMCS survey data on visits, Centricity EMR data shows higher proportions of visits by younger patients and by females. Other comparisons suggest more acute …

Defining And Measuring The Patient-Centered Medical Home., Kurt C Stange, Paul A Nutting, William L Miller, Carlos R Jaén, Benjamin F Crabtree, Susan A Flocke, James M Gill

Department of Family & Community Medicine Faculty Papers

The patient-centered medical home (PCMH) is four things: 1) the fundamental tenets of primary care: first contact access, comprehensiveness, integration/coordination, and relationships involving sustained partnership; 2) new ways of organizing practice; 3) development of practices' internal capabilities, and 4) related health care system and reimbursement changes. All of these are focused on improving the health of whole people, families, communities and populations, and on increasing the value of healthcare. The value of the fundamental tenets of primary care is well established. This value includes higher health care quality, better whole-person and population health, lower cost and reduced inequalities compared to …

Multiport Minimally Invasive Skull Base Surgery: How Many Ports Are Too Many?, Yaron A. Moshel, Theodore H. Schwartz

Department of Neurosurgery Faculty Papers

Surgical access to the ventral skull base has evolved considerably over the past several years with the introduction of minimally invasive endoscopic and endoscope-assisted approaches. The accompanying manuscript by Ciporen et al. demonstrates an addition to this growing body of literature in their description of the feasibility of multiportal endoscopic approaches to the skull base, particularly the precaruncular transorbital approach, in a series of cadaver dissections. Similar to laparoscopic abdominal surgery, which utilizes multiple small ports to improve visualization and manipulation, they envision a modular combination of approaches that allows an endoscope to be placed in one port and surgery …

Physiologically Based Pharmacokinetics Of Molecular Imaging Nanoparticles For Mrna Detection Determined In Tumor-Bearing Mice., Armin W Opitz, Eric Wickstrom, Mathew L Thakur, Norman J Wagner

Kimmel Cancer Center Faculty Papers

Disease detection and management might benefit from external imaging of disease gene mRNAs. Previously we designed molecular imaging nanoparticles (MINs) based on peptide nucleic acids complementary to cancer gene mRNAs. The MINs included contrast agents and analogs of insulin-like growth factor 1 (IGF-1). Analysis of MIN tumor uptake data showed stronger binding in tumors than in surrounding tissues. We hypothesized that MINs with an IGF-1 analog stay in circulation by binding to IGF-binding proteins. To test that hypothesis, we fit the tissue distribution results of several MINs in xenograft-bearing mice to a physiological pharmacokinetics model. Fitting experimental tissue distribution data …

Splenic Infarction: An Update On William Osler's Observations., Yaacov R Lawrence, Ma Mbbs Mrcp, Russell Pokroy, Mb Bch, Daniel Berlowitz, Mb Bch, Dvora Aharoni, Md, Daniel Hain, Md, Gabriel S Breuer, Md

Department of Radiation Oncology Faculty Papers

BACKGROUND: Osler taught that splenic infarction presents with left upper abdominal quadrant pain, tenderness and swelling accompanied by a peritoneal friction rub. Splenic infarction is classically associated with bacterial endocarditis and sickle cell disease.

OBJECTIVES: To describe the contemporary experience of splenic infarction.

METHODS: We conducted a chart review of inpatients diagnosed with splenic infarction in a Jerusalem hospital between 1990 and 2003.

RESULTS: We identified 26 cases with a mean age of 52 years. Common causes were hematologic malignancy (six cases) and intracardiac thrombus (five cases). Only three cases were associated with bacterial endocarditis. In 21 cases the splenic …

Current Concepts: Neonatal Brachial Plexus Pals, Joshua M. Abzug, Md, Scott H. Kozin, Md

Department of Orthopaedic Surgery Faculty Papers

Neonatal brachial plexus palsy may be decreasing in incidence; however, conflicting reports exist. Regardless, neonatal brachial plexus palsy has an incidence of 1 to 2 per 1000 live births making this a frequent occurrence. The majority of infants with brachial plexus palsy spontaneously recover in the first 2 months of life and subsequently progress to near complete recovery of motion and strength. However, those infants who do not have substantial recovery by age 3 months will have permanent limited range of motion, less strength, and a decrease in size and girth of the involved extremity. Currently, debate continues about the …

Assessment Of Epidermal Growth Factor Receptor (Egfr) Expression In Human Meningioma., A Gabriella Wernicke, Adam P Dicker, Michal Whiton, Jana Ivanidze, Terry Hyslop, Elizabeth H Hammond, Arie Perry, David W Andrews, Lawrence Kenyon

Kimmel Cancer Center Faculty Papers

PURPOSE: This study explores whether meningioma expresses epidermal growth factor receptor (EGFR) and determines if there is a correlation between the WHO grade of this tumor and the degree of EGFR expression.

METHODS: Following institutional review board approval, 113 meningioma specimens from 89 patients were chosen. Of these, 85 were used for final analysis. After a blinded review, immunohistochemical stains for EGFR were performed. Staining intensity (SI) was scored on a scale 0-3 (from no staining to strong staining). Staining percentage of immunoreactive cells (SP) was scored 1-5 (from the least to the maximum percent of the specimen staining). Immunohistochemical …

Reducing The Effects Of Intracellular Accumulation Of Thermolabile Collagen Ii Mutants By Increasing Their Thermostability In Cell Culture Conditions., Katarzyna Gawron, Deborah A. Jensen, Andrzej Steplewski, Andrzej Fertala

Department of Dermatology and Cutaneous Biology Faculty Papers

Mutations in collagen II are associated with spondyloepiphyseal dysplasia, a group of heritable diseases whose common features include aberrations of skeletal growth. The mechanisms through which mutations in collagen II affect the cartilaginous tissues are complex and include both intracellular and extracellular processes. One of those mechanisms involves cellular stress caused by excessive accumulation of misfolded collagen II mutants. We investigated whether stabilizing the structure of thermolabile R789C and R992C collagen II mutants would improve their secretion from cells, thereby reducing cellular stress and apoptosis. Employing glycerol and trimethylamine N-oxide (TMAO), chemicals that increase the thermostability of collagen triple helices, …

4 Wikis + 4 Blogs + 70 Third Year Medical School Students = Improved Students’ Confidence In Practicing Ebm. A Pilot Project Using Blogs And Wikis For A Collaborative Ebm Assignment In A 3rd Year Internal Medicine Clerkship., Jessica Salt, Md Facp, Anthony J. Frisby, Phd, Margy Grasberger, Ms, Gary Kaplan, Ms, Daniel G. Kipnis, Msi, Karen Krasznavolgyi, Mls, Jon Veloski, Ms

Academic Commons and Scott Memorial Library Staff Papers and Presentations

PowerPoint presented at national Medical Library Association conference in Washington DC on May 25, 2010, 2:00 PM - 3:30 PM Section Program: Beyond Cool: Reflecting on Web 2.0 Adventures and Misadventures.

Good Publication Practice: Maintaining The Integrity Of Scientific Communications, Jackie Mayne Msc

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

7th Annual Interclerkship Day: Improving Patient Safety

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Young Journalists Deliver Public Health Message, Marian Uhlman, Moriah Zimmerman Mph

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Health Policy Forum: Future Implications And The Role Of The Physician Advocate

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Health Policy Forum: Achieving Cultural Competency: Using A Case-Based Approach For Teaching And Learning

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Creating Our Future Leaders: Amsa 2nd Annual Patient Safety And Quality Leadership Institute, Justin Abraham

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Partnerships For Health In Rwandan Genocide Survivers Village: The Rwanda Health And Healing Project And Barefoot Artists, James Plumb Md, Mph

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

The Adventure Of Helping Abroad: Experiences Providing Health Care In Ethiopia. Interview With Jeffrey Panzer, Md, And Erin Mc Carville, Mph

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Moving Forward: Jsph To Launch Online Courses

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

American Medical Association - Medical Student Section Region Vi Conference, Zein Nakhoda

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Wii-Hab: Using The Wii Video Game System As An Occupational Therapy Intervention With Patients In The Hospital Setting, Kimberly Gargin Otr/L, Lauren Pizzi Otr/L

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

The Future Health Care Workforce Of Older Americans, Richard G. Stefanacci Do, Mgh, Mba, Christine A. Arenson Md, Barney S. Spivack Md, Facp, Agsf, Cmd

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

One Book, One School, Kathyrn Kash Phd, David B. Nash Md, Mba

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Hp Newsletter March 2010 Dowload Full Pdf

Population Health Matters (Formerly Health Policy Newsletter)

No abstract provided.

Reduction Of Sympathetic Activity Via Adrenal-Targeted Grk2 Gene Deletion Attenuates Heart Failure Progression And Improves Cardiac Function After Myocardial Infarction., Anastasios Lymperopoulos, Giuseppe Rengo, Erhe Gao, Steven N. Ebert, Gerald W. Dorn, Walter J. Koch

Department of Medicine Faculty Papers

Chronic heart failure (HF) is characterized by sympathetic overactivity and enhanced circulating catecholamines (CAs), which significantly increase HF morbidity and mortality. We recently reported that adrenal G protein-coupled receptor kinase 2 (GRK2) is up-regulated in chronic HF, leading to enhanced CA release via desensitization/down-regulation of the chromaffin cell alpha(2)-adrenergic receptors that normally inhibit CA secretion. We also showed that adrenal GRK2 inhibition decreases circulating CAs and improves cardiac inotropic reserve and function. Herein, we hypothesized that adrenal-targeted GRK2 gene deletion before the onset of HF might be beneficial by reducing sympathetic activation. To specifically delete GRK2 in the chromaffin cells …

Correlation Of C2 Fractures And Vertebral Artery Injury., Tao Ding, Mitchell Maltenfort, Huilin Yang, Harvey Smith, John Ratliff, Alexander Vaccaro, D Greg Anderson, James Harrop

Department of Orthopaedic Surgery Faculty Papers

STUDY DESIGN: Retrospective review of prospectively collected data.

SUMMARY OF BACKGROUND DATA: Vertebral artery injuries (VAI) occur commonly after cervical spine trauma. No study has yet examined the association between VAI and specific variants of C2 fractures.

OBJECTIVE: To evaluate the incidence of VAI (as defined by magnetic resonance imaging/angiography [MRI/A]) in subtypes of C2 fractures. To define the association between the incidence, morphology, and severity of C2 fractures, based on fracture angulation and comminution, and the occurrence of VAI.

METHODS: Patients admitted to the hospital with C2 fractures between October 2006 and December 2008 to a tertiary care referral …

Panel: Access To Healthy Food And Physical Activity-The Philadelphia Urban Food And Fitness Alliance (Puffa), Diane-Louise (D-L) Wormley

Moving Philadelphia! Creating Healthier Communities

Diane-Louise (D-L) Wormley is the Project Director for PUFFA (Philadelphia Urban Food and Fitness Alliance), which centers on developing a grassroots collaborative devoted to bringing about systems change through education and advocacy by community residents and youth in partnership with experts. She has experience in working with community residents, developing and implementing community development programs, facilitating groups, designing training and bridging community differences. She designed Penn’s community housing program which included the rehab of long-term vacant homes and a special mortgage program for employees.

D-L received her BA in Comparative Literature from William Smith College and has completed the Institute …

Panel: Cycling Intiatives Impacting On Policy And Programs, Ryan Oelkers, Kristin Gavin

Moving Philadelphia! Creating Healthier Communities

Ryan Oelkers

Ryan is the Executive Director of Cadence Cycling Foundation (CCF), which was founded in 2007, with the support of Jay Snider, Cadence Cycling & Multisport owner and former President of the Philadelphia Flyers. CCF is a non-profit organization with a mission to Help Kids Create Opportunities through Cycling. CCF helps Philadelphia youth between the ages of 9 and 18 discover the possibilities that the sport of cycling has to offer and helps develop life skills, goal setting, self-esteem, teamwork and commitment.

The Cadence Cycling Foundation has also developed the Cadence College ConneXion (CCC) to help kids transfer all …

Overview Of The National Physical Activity Plan, Allison Topper-Kleinfelter, Ms

Moving Philadelphia! Creating Healthier Communities

Allison Topper-Kleinfelter is a national leader in health promotion planning and marketing. Her specific area of expertise lies in social marketing, culture change, obesity prevention, public health planning, and development of public-private partnerships. Allison has helped to mobilize policy and practice changes to improve nutrition and physical activity behaviors.

Allison is a national planning team contributor for the National Activity Plan, Comprehensive School Physical Activity Plan, Cardiovascular Disease Prevention Plan, and Children and Nature Strategies for Recreation and Healthcare.

She is also Founder and CEO of achievABILITY where she provides consultation to public and private organizations working to improve nutrition …

The Role Of The Built Environment, Richard Killingsworth, Mph

Moving Philadelphia! Creating Healthier Communities

Mr. Killingsworth is nationally recognized for his pioneering efforts in cultivating the emerging domains of active living and placemaking – an applied science that considers the impact of the built environment on health. He has provided technical assistance to numerous federal agencies, national organizations, municipalities, and elected officials. He has consulted in over 300 communities; presented at over 100 national conferences; authored over 30 different peer reviewed publications; provided Congressional testimony; served on research and policy projects with the Centers for Disease Control, National Institutes of Health, National Academy of Sciences, and the World Health Organization; advised Health Canada and …