Medicine and Health Sciences Commons^™

Individual Agency, Community Capacity Building, And Chronic Illness Care: Using Participatory Methods To Implement The Stanford Chronic Disease Self Management Program In A Housing First Program, Lara Carson Weinstein, Md, Mph, Abbie Santana, Msph, Carolyn Armour, Cornelius Crossan, James Lawson, Karen Webb

Department of Family & Community Medicine Presentations and Grand Rounds

Research questions:

Is a standardized chronic disease self management program (CDSMP) experienced as a valuable intervention by Pathways' consumers?

What is the impact of collaborative inquiry into health program development on participant's critical agency?

Expression Of Cancer Stem Cell Biomarkers In Male Breast Cancer, Ping Gong, Md, Juan P. Palazzo, Md

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Male breast cancer is an uncommon disease, representing <1% of all breast cancer diagnoses. The prognostic factors and expression of molecular markers in male breast carcinomas are similar to female cancer. Cancer stem cell (CSC)s have been associated with tumor aggressiveness and drug resistance. CSCs are characterized by CD44 and/or ALDH1 expression. We investigated their expression in male breast cancer.

Childhood Obesity And Blood Pressure: Back To The Future?, Bonita Falkner, Samuel Gidding

Department of Pediatrics Faculty Papers

The prevalence of childhood hypertension is increasing.^{1, 2} Studies that apply the 95^th percentile definition and repeat measurements on three separate visits, report a pediatric hypertension prevalence of approximately 3.5%^{3, 4}, and among obese children and adolescents the prevalence of both hypertension and prehypertension is even greater. The recently documented increase in hypertension among the young is due largely to the childhood obesity epidemic and possibly other secular changes in lifestyles. These publications and others confirm that hypertension is a prevalent child health condition, especially among overweight and obese children. A consistent positive association between body …

Abca12-Mediated Lipid Transport And Snap29-Dependent Trafficking Of Lamellar Granules Are Crucial For Epidermal Morphogenesis In A Zebrafish Model Of Ichthyosis., Qiaoli Li, Michael Frank, Masashi Akiyama, Shiu-Ying Ho, Hiroshi Shimizu, Christine Thisse, Bernard Thisse, Eli Sprecher, Jouni Uitto

Department of Dermatology and Cutaneous Biology Faculty Papers

Zebrafish (Danio rerio) can serve as a model system to study heritable skin diseases. The skin is rapidly developed during the first 5-6 days of embryonic growth, accompanied by expression of skin-specific genes. Transmission electron microscopy (TEM) of wild-type zebrafish at day 5 reveals a two-cell-layer epidermis separated from the underlying collagenous stroma by a basement membrane with fully developed hemidesmosomes. Scanning electron microscopy (SEM) reveals an ordered surface contour of keratinocytes with discrete microridges. To gain insight into epidermal morphogenesis, we have employed morpholino-mediated knockdown of the abca12 and snap29 genes, which are crucial for secretion of lipids and …

About The Authors

Jefferson Journal of Psychiatry

List of authors for Jefferson Journal of Psychiatry, Volume 8, Number 1, 1990.

Letters To The Editor

Jefferson Journal of Psychiatry

Letters to the Editor for Jefferson Journal of Psychiatry, Volume 8, Number 1, 1990.

Book Review: Biologic Psychiatry For The Biologist, John P. Seibyl, M.D.

Jefferson Journal of Psychiatry

PSYCHOPHARMACOLOGY: THE THIRD GENERATION OF PROGRESS

Edited by Herbert Y. Meltzer, M.D .New York, Raven Press, 1987

1824 pages, $160.00

Book Review: Illness Or Person?, Beth Z. Mark, M.D.

Jefferson Journal of Psychiatry

Book Review of:

PSYCHOTHERAPY OF NEUROTIC CHARACTER

Dana Shapiro

New York, Basic Books, 1989

In Response: A Practical Approach To The Assessment And Management Of Psychiatric Emergencies, William R. Dubin, M.D.

Jefferson Journal of Psychiatry

I would like to respond to the article entitled "A Practical Approach to the Assessment and Management of Psychiatric Emergencies" (Jefferson Journal of Psychiatry, Vol. 7:8 I-9 1, 1989). The authors are to be congratulated for their concise distillation of the major clinical problems encountered in emergency psychiatry. However, there are several aspects of this review which require further amplification and clarification.

Psychiatrists' Knowledge And Attitudes About The Acquired Immune Deficiency Syndrome, Carol L. Alter, M.D., Ellen S. Dickinson, M.D., Greg Miller, M.D.

Jefferson Journal of Psychiatry

Since 1981 the Acquired Immune Deficiency Syndrome (AIDS) has become the primary health care issue in this nation. Psychiatrists have had a central role in caring for AIDS patients: they have been asked to evaluate and treat patients with neuropsychiatric manifestations of AIDS and emotional reactions to the illness itself, as well as to treat those who are fearful of acquiring AIDS. Numerous studies in the literature have explored the physician and lay population's knowledge and attitudes about AIDS. To date no study has addressed these issues in psychiatrists in specific (1- 9).

Most studies suggest that individuals who have …

The Homicide Witness And Victimization; Ptsd In Civilian Populations: A Literature Review, Gerald M. Streets, M.D.

Jefferson Journal of Psychiatry

People who witness the murder of an individual, whether a family member or acquaintance, often experience their loss as a psychic trauma. This described trauma is revealed by the symptom complex defined in the DSM-III-R as post -traumatic stress disorder (PTSD). Children, in particular, frequently suffer from debilitating grief, which hinders their emotional and cognitive development. This grief may masquerade as a learning disability, hyperactivity, or an attention deficit disorder. Witnessing murder and being victimized (i.e, rape, incest, and physical abuse) are equivalent experiences in their potential for generating massive intrapsychic conflict. Being poor is a predisposing factor which puts …

Exploring Frontal Lobe Dysfunction In Schizophrenia With Positron Emission Tomography, Donald P. Hall, Jr., M.D.

Jefferson Journal of Psychiatry

Frontal lobe dysfunction in schizophrenic pa tients has been highly suspected for many years. Many psychiatrists and patients, however, are awaiting solid proof of a biological manifestation of this disease. While positron emission tomography does not uniformly demonstrate such a manifestation, it does demonstrate a prefrontal cortex deficit in most reported studies. Further, a localization of the attention deficit of schizophrenia, in the prefrontal cortex, is strongly suggested by some studies.

INTRODUCTION

Positron emission tomography (PET) has enabled investigators in modern clinical psychiatry to demonstrate that schizophrenia is, at least in part, a frontal lobe disorder. PET studies of many …

A Case Of Conversion Catatonia Misdiagnosed For 24 Years, Pauline K. Wiener, M.D.

Jefferson Journal of Psychiatry

Catatonia is a syndrome whose etiology may be both diverse and difficult to substantiate. Ms. H. is a 45-year-old black female with 18 previous psychiatric hospitalizations beginning at age 21. A common characteristic to all hospitalizations was a catatonic presentation (i.e ., the patient was mute with marked muscular rigidity; she would refuse to eat or follow orders). In each of her previous 18 hospitalizations, the patient was thought to be psychotic.

It was found that each catatonic episode could be related to a severe psychological stressor. The patient's illness never involved delusions, hallucinations or disturbances in thought form. Upon …

Enhancing The Utility Of The Dexamethasone Suppression Test: A Chart Review And Application Of Bayes' Theorem, Scott B. Patten, M.D.

Jefferson Journal of Psychiatry

The dexamethasone suppression test (DST) is the most extensively studied biological test in psychiatry. Despite this, its role in the diagnostic assessment of psychiatric patients remains controversial. Shortcomings of the test include limited sensitivity (45%) and limited specificity (75-80%) (1). The DST has many proposed uses, including the differentiation of endogenous from non-endogenous depressions, helping to decide when maintenance medications may be withdrawn, and as a diagnostic test for major depression. This paper is concerned with the latter use only, that is, the ability of the DST to function as a useful diagnostic test for major depression.

The significance of …

Reliability Of Trainees' Endorsements On Standardized Psychiatric Interviews, Thomas E. Uttley, M.D.

Jefferson Journal of Psychiatry

This study investigated the utilization of standardized psychiatric interviews (SPI's) in psychiatric training programs. As the field of psychiatry, and the training of its' new members moves to conformits' principles to scientific models, the reliable use of SPI's is use ful in reaching that goal, in both research and diagnostic applications. This investigation contains two studies. In Study 1, a random survey of 20 percent of all psychiatric residency training programs was conducted to determine the prevailing level of training devoted to SPI's. The resulting findings are referred to as "training as usual" (TAU). Study 1 shows that residents are …

Imipramine In The Treatment Of Obsessive-Compulsive Symptoms In Schizophrenic Spectrum Illnesses: Three Case Reports, Ileana Zaharovits, M.D., Marvin H. Lipkowitz, M.D.

Jefferson Journal of Psychiatry

It has long been known that obsessions and compulsions occur during the course of a schizophrenic illness (1- 7). It is, therefore, of interest that there has been little systematic research into the treatment of these symptoms in patients suffering from schizophrenia.

It is possible that the meager research in this area is related both to the difficulty at times in differentiating signs of a psychotic decompensation in severe obsessive-compulsive disorder (OeD) from those of schizophrenia; and to the significant amount of controversy regarding the function of obsessive compulsive symptoms in patients suffering from schizophrenia and related diseases. For example, …

Postpartum Depression In A Caretaking Grandmother: Case Report, Valerie D. Raskin, M.D.

Jefferson Journal of Psychiatry

Postpartum depression has only recently been understood to affect individuals other than the biological mother (1). In such cases, postpartum depression has been attributed to the enormous psychological and social stress of the caretaking role, with its demands to nurture in the face of what may be the sense of having been insufficiently nurtured oneself (2). A growing number of grandparents, especially maternal grandmothers, are being asked to serve as primary caretakers for their grandchildren, due to circumstances which include adolescent childbearing, single parent families and substance abuse. A case report of a new grandmother with significant caretaking functions who …

Treating Dual Diagnosis Patients: Challenges And Opportunities, Robert H. Howland, M.D.

Jefferson Journal of Psychiatry

The use and abuse of drugs and alcohol have recently gained greater attention both from the public and the medical profession. Despite increasing cognizance of its unfortunate consequences, substance use has become a more pervasive element of contemporary society. As substance abuse has come to affect more segments of the population, it is not surprising that this problem also has affected the mentally ill. Awareness of the mentally ill substance abuser has grown, although this population has not been well studied or well served by the mental health system. These dually diagnosed patients often are depicted as the square pegs …

Special Article: One Resident's Perspective On A Different Style Of Psychopharmacological Practice, Michael Amiel, M.D., Docteur J.P. Blayac

Jefferson Journal of Psychiatry

This article provides a comparison of psychopharmacological practices in the U.S. and France. The prescription as well as proscription of various classes of psychotropic drugs are considered. Even though the general guidelines of psychopharmacological practice remain the same, the details vary considerably and are determined especially by commercial factors.

INTRODUCTION

Though a comparison of current clinical psychopharmacological practices in France and the U.S. is an unaddressed topic, these contrasts may be quite striking to an American-trained psychiatrist. The following observations are based on my two month inpatient experience as a fourth-year psychiatric resident at a public psychiatric institution located in …

Mead Johnson Award

Jefferson Journal of Psychiatry

The Mead Johnson Award has been established to honor the best paper submitted to The Jefferson Journal of Psychiatry: A Resident Publication during each calendar year. An award of one thousand dollars is given to the chosen author, with an additional one thousand dollars to be given to the residency program or fellowship in which the author is enrolled. The winning submission will be selected by the Journal's editorial board from manuscripts submitted on any subject related to psychiatric practice and/or research. We invite authors to review the Information for Contributors section of this issue. The board will announce …

Editor's Column, Elizabeth Trefzger, Md

Jefferson Journal of Psychiatry

In selecting articles for, and preparing this latest issue of the Jefferson Journal, I am impressed by the ongoing trend towards refinement that is present in the submissions which we receive. This has been both encouraging and exciting for everyone concerned with the production of the Journal. Much as any other piece of scientific literature, the value of criticism in the production of the work cannot be forgotten . While reflecting on the need for refined and worthwhile criticism I have been reminded of the value of criticism in education. It is through criticism, our own self evaluation, and that …

Resident Editorial Board

Jefferson Journal of Psychiatry

List of Resident Editorial Board for Jefferson Journal of Psychiatry, Volume 8, Number 1, 1990.

Trick Or Truth? Accessing Accurate Health Information On The Web, Gary Kaplan, Mslis, Ingrid Hilghman, Msn, Rn

Academic Commons and Scott Memorial Library Staff Papers and Presentations

Learning objectives:

* Identify 2 locations to access the internet

* Identify website resources that can be searched to locate reliable health information

* Describe 2 items that can be found on a website to analyze content

* Describe the purpose of a Personal Health Record

A 2-Step Approach To Myeloablative Haploidentical Stem Cell Transplantation: A Phase 1/2 Trial Performed With Optimized T-Cell Dosing., Dolores Gross, Matthew Carabasi, Joanne Filicko-O'Hara, Margaret Kasner, John L Wagner, Beth Colombe, Patricia Cornett Farley, William O'Hara, Phyllis Flomenberg, Maria Werner-Wasik, Janet Brunner, Bijoyesh Mookerjee, Terry Hyslop, Mark Weiss, Neal Flomenberg

Department of Medical Oncology Faculty Papers

Studies of haploidentical hematopoietic stem cell transplantation (HSCT) have identified threshold doses of T cells below which severe GVHD is usually absent. However, little is known regarding optimal T-cell dosing as it relates to engraftment, immune reconstitution, and relapse. To begin to address this question, we developed a 2-step myeloablative approach to haploidentical HSCT in which 27 patients conditioned with total body irradiation (TBI) were given a fixed dose of donor T cells (HSCT step 1), followed by cyclophosphamide (CY) for T-cell tolerization. A CD34-selected HSC product (HSCT step 2) was infused after CY. A dose of 2 × 10(8)/kg …

About The Authors

Jefferson Journal of Psychiatry

About the authors in the Jefferson Journal of Psychiatry, Volume 7, Number 2, 1989.

Letters To The Editor

Jefferson Journal of Psychiatry

Letters to the Editor to Jefferson Journal of Psychiatry, Volume 7, Number 2, 1989.

Book Review: Humanizing Freud, Edward Kim, M.D.

Jefferson Journal of Psychiatry

FREUD: A LIFE FOR OUR TIME

Peter Gay, Ph.D.

W.W. Norton & Company

New York, 1988 651 pages

$25.00

Book Reviews: Clinical Experiences, Indoctrination And Education In Alcoholism, Marguerite M. Blythe, M.D.

Jefferson Journal of Psychiatry

HEAVY DRINKING: THE MYTH OF ALCOHOLISM AS A DISEASE

Herbert Fingarette

Berkeley, University of California Press 1988, 166 pages

In Response: The Place Of Psychotherapy Training In Residency Programs, Homer C. Curtis, M.D.

Jefferson Journal of Psychiatry

As a belated response to the debate about the value of teaching psychotherapy in psychiatric residency training, (Jefferson Journal of Psychiatry, Vol. 5(I):54-66, 1987) I would like to add my voice to the affirmative side. That there is such a debate seems symptomatic of an unfortunate and unnecessary misuse of important advances in neurobiology to justify the sidelining of psychodynamic psychotherapy. A search of the psychiatric literature of recent years reveals an emphasis on biological psychiatry and a relative neglect of psychotherapy. A similar trend has been noted in some residency programs and in the annual meetings of the American …

A Practical Approach To The Assessment And Management Of Psychiatric Emergencies, J. Gregory Kyser, M.D., Bradley C. Diner, M.D., Gilbert W. Raulston, M.D.

Jefferson Journal of Psychiatry

Patients present to the psychiatric emergency room manifesting a wide variety of symptoms ranging from mild anxiety to violent, uncontrollable behavior. The emergency room psychiatrist must recognize these various presentations and provide appropriate interventions for such patients. It may not be of the utmost importance to distinguish between the subtypes of schizophrenia or endogenous vs. exogenous depression, just as it is not crucial to decide immediately the cause of an acute abdomen, primarily to recognize its presence. However, it is critical to recognize the presence of a psychosis, suicidal intent or the presence of an organically caused alteration in mental …