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Articles 7321 - 7350 of 8080
Full-Text Articles in Medicine and Health Sciences
Effect Of Melatonin On Hepatic Fibrogenesis, Vitamin C And Hydroxyproline Levels In Liver Of Ethanol-Fed Rats, Bi̇lal Üstündağ, Nadi̇re Çi̇nkilinç, İhsan Hali̇feoğlu, Hali̇t Canatan, İbrahi̇m Hani̇fi̇ Özercan
Effect Of Melatonin On Hepatic Fibrogenesis, Vitamin C And Hydroxyproline Levels In Liver Of Ethanol-Fed Rats, Bi̇lal Üstündağ, Nadi̇re Çi̇nkilinç, İhsan Hali̇feoğlu, Hali̇t Canatan, İbrahi̇m Hani̇fi̇ Özercan
Turkish Journal of Medical Sciences
Pineal-gland-derived melatonin (N- Acetyl 5-Methoxytryptamine), which is a known antioxidant hormone, is known to have inhibitory effects on cell growth and proliferation. Ethanol causes increases in lipid peroxidation, superoxide formation and collagen synthesis resulting in fibrosis in the liver due to alcohol intake. The aim of this study was to examine the effect of exogenously administered melatonin on liver tissue damage resulting from alcohol intake. A total of 30 male wistar albino rats were divided into three groups; Group 1 (control), Group 2 (ethanol-administration), and Group 3 (ethanol +melatonin administration). All the rats were fed with a specially modified diet …
Electrochemical Biosensor Based On Horseradish Peroxidase For The Determination Of Oxidizable Drugs, Arzum Erdem, Aysun Pabuccuoğlu, Burcu Meric, Kagan Kerman, Mehmet Özsöz
Electrochemical Biosensor Based On Horseradish Peroxidase For The Determination Of Oxidizable Drugs, Arzum Erdem, Aysun Pabuccuoğlu, Burcu Meric, Kagan Kerman, Mehmet Özsöz
Turkish Journal of Medical Sciences
An amperometric biosensor based on a carbon paste electrode modified with horseradish peroxidase (HRP) is defined as a device for the quantitative and qualitative detection of oxidizable drugs. This paper demonstrates the advantages of using HRP as the biocatalyst in the in vitro detection of oxidizable drugs in the presence of hydrogen peroxide. Amperometric analysis and batch experiments were carried out in acetate buffer (pH 4.8) in the presence of hydrogen peroxide. Amperometry was performed by applying a potential of -0.1 V (vs. Ag/AgCl), in the presence of hydrogen peroxide and adding a drug which has an oxidizable group (OxG; …
Sertoli Cell Tumor In Two Sibs With Testicular Ferminization Syndrome, İnanç Eli̇f Gürer, Ahmet Ender Demi̇rkiran, Mustafa Şare
Sertoli Cell Tumor In Two Sibs With Testicular Ferminization Syndrome, İnanç Eli̇f Gürer, Ahmet Ender Demi̇rkiran, Mustafa Şare
Turkish Journal of Medical Sciences
No abstract provided.
Disseminated Mycobacterium Fortuitum- Chelonae Complex Infection In A Child With Il-12 Receptor Deficiency, Sadik Akşi̇t, Deni̇z Yilmaz, Şükran Darcan, Sali̇ha Soydan, Cengi̇z Çavuşoğlu, Erol Balik, Jean Laurent Casanova, Neci̇l Kütükçüler
Disseminated Mycobacterium Fortuitum- Chelonae Complex Infection In A Child With Il-12 Receptor Deficiency, Sadik Akşi̇t, Deni̇z Yilmaz, Şükran Darcan, Sali̇ha Soydan, Cengi̇z Çavuşoğlu, Erol Balik, Jean Laurent Casanova, Neci̇l Kütükçüler
Turkish Journal of Medical Sciences
No abstract provided.
Colchicine Toxicity: A Patient With Pneumopericardium, Yüksel Gökel, Abdullah Canataroğlu, Sali̇m Satar, Zi̇kret Köseoğlu
Colchicine Toxicity: A Patient With Pneumopericardium, Yüksel Gökel, Abdullah Canataroğlu, Sali̇m Satar, Zi̇kret Köseoğlu
Turkish Journal of Medical Sciences
No abstract provided.
Cholesterol Granuloma Mass In The Middle Ear Cavity, Murat Ünal, İsmai̇l Çölhan, Yusufhan Süoğlu, Ekrem Yavuz, Tayfun Sunay
Cholesterol Granuloma Mass In The Middle Ear Cavity, Murat Ünal, İsmai̇l Çölhan, Yusufhan Süoğlu, Ekrem Yavuz, Tayfun Sunay
Turkish Journal of Medical Sciences
No abstract provided.
Nitric Oxide In Chronic Liver Disease, Güldal Kirkali, Semra Gezer, Nurcan Umur, Mehmet Ali̇ Özcan, Ethem Tankurt
Nitric Oxide In Chronic Liver Disease, Güldal Kirkali, Semra Gezer, Nurcan Umur, Mehmet Ali̇ Özcan, Ethem Tankurt
Turkish Journal of Medical Sciences
The formation of nitric oxide (NO), a free radical, increases in liver disease, where the L-arginine-nitric oxide (L- arg-NO) pathway is activated by the increased levels of cytokines and endotoxins. In this study, we investigated the relationship between the L-arg-NO pathway and chronic active hepatitis and cirrhosis, which are classified as chronic liver disease. We determined the serum levels of nitrite and nitrate, the end products of the L-arg-NO pathway, in patients with chronic liver disease and compared them with the control group levels. Total nitrite produced by the reduction of nitrate to nitrite in the presence of nitrate reductase …
Effect Of The Combination Of Glibenclamide, An Atp-Dependent Potassium Channel Blocker, And Metoprolol, A Cardioselective B-Adrenoceptor Blocker, During Myocardial Infarction In Conscious Rats, Ömer Bozdoğan, Istvan Lepran, Julğus Gy. Papp
Effect Of The Combination Of Glibenclamide, An Atp-Dependent Potassium Channel Blocker, And Metoprolol, A Cardioselective B-Adrenoceptor Blocker, During Myocardial Infarction In Conscious Rats, Ömer Bozdoğan, Istvan Lepran, Julğus Gy. Papp
Turkish Journal of Medical Sciences
We investigated the possible interaction of glibenclamide and metoprolol on the occurrence of life threatening arrhythmias during the acute phase of experimental myocardial infarction. Coronary artery ligation was performed in conscious rats and ECG was recorded for 15 min following ligation. Neither metoprolol (2 mg/kg i.p., 20 min before coronary artery ligation), nor glibenclamide (5 mg/kg i.p., 30 min before ligation) pretreatment increased significantly the survival rate during the acute phase of myocardial infarction (10 % and 22 %, respectively vs. 9 % in controls). Combination of glibenclamide with metoprolol, however, significantly improved the survival rate (62 %, P < 0.05). These results suggest that the combination of a cardioselective b-blocking agent with an ATP- dependent potassium channel inhibitor may result in an enhanced antiarrhythmic effect during the acute phase of myocardial infarction.
Effects Of Growth Hormone On Hepatic Regeneration, Mahmut Başoğlu, Ahmet A. Balik, İbrahi̇m Kavak, Cemal Gündoğdu, Zekai̇ Erman, İlhan Yildirgan, Durkaya Ören
Effects Of Growth Hormone On Hepatic Regeneration, Mahmut Başoğlu, Ahmet A. Balik, İbrahi̇m Kavak, Cemal Gündoğdu, Zekai̇ Erman, İlhan Yildirgan, Durkaya Ören
Turkish Journal of Medical Sciences
The aim of this experimental study was to determine the effects of growth hormone on hepatic regeneration after partial hepatectomy. Thirty pathogen free Sprague-Dawley rats were divided into three groups, each containing 10 rats. The animals were subjected to a sham operation in Group 1, and to left hepatic lobectomy in Groups 2 and 3. The animals in Groups 1 and 2 received saline solution (0.2 mg/kg/day), while growth hormone (Lilly Humotrope, Lilly France Usine de Fegersheim, France) (0.2 mg/kg/day) was given to the animals in Group 3 for seven days. On the seventh postoperative day, the animals were sacrificed …
Mechanical And Thermal Properties Of Hydroxyapatite-Impregnated Bone Cement, Kemal Şerbetçi̇, Feza Korkusuz, Nesri̇n Hasirci
Mechanical And Thermal Properties Of Hydroxyapatite-Impregnated Bone Cement, Kemal Şerbetçi̇, Feza Korkusuz, Nesri̇n Hasirci
Turkish Journal of Medical Sciences
Self-curing acrylic cements, consisting mainly of polymethylmethacrylate (PMMA), are widely used in dentistry and orthopedic surgery. One of the major side effects of the standard PMMA application is tissue necrosis at the bone-cement interface due to the rise of temperature during the polymerization reaction. This may also lead to aseptic loosening over time. Therefore, intense research is being carried out in the development of bone cements with new compositions. In this study, the aim was to develop new bone cement compositions that would have low setting temperature and high mechanical strength and be comparable with the commercially available ones. For …
Histopathological Effects Of Cholesterol And Protective Effects Of Vitamin E And Selenium On The Morphology Of Liver, Süheyla Gonca, Süreyya Ceylan, Melda Yardimoğlu, Hakki Dalçik, Si̇bel Köktürk, Serdar Fi̇li̇z, Zuhal Yumbul
Histopathological Effects Of Cholesterol And Protective Effects Of Vitamin E And Selenium On The Morphology Of Liver, Süheyla Gonca, Süreyya Ceylan, Melda Yardimoğlu, Hakki Dalçik, Si̇bel Köktürk, Serdar Fi̇li̇z, Zuhal Yumbul
Turkish Journal of Medical Sciences
In this study, effects of cholesterol and protective effects of vitamin E (vit E) and Selenium (Se) on the morphology of the liver in rats were observed. Cholesterol (Chol) supplemented diet, Chol + vit E, Chol + Se and Chol + vit E + Se were applied to the rats. Portal fibrosis with bile ductal proliferation and an increased inflammatory infiltration were seen in Chol group. In this group, ultrastructurally, granular endoplasmic reticulum (GER) arrangement was seen in irregular shape in hepatocyte cytoplasm. The membranes of GER and mitochondria were not seen clearly. A morphological improvement was seen in the …
Effects Of Garlic On Aerobic Performance, Deni̇z İnal İnce, Gül Ti̇ryaki̇ Sönmez, Mustafa Levent İnce
Effects Of Garlic On Aerobic Performance, Deni̇z İnal İnce, Gül Ti̇ryaki̇ Sönmez, Mustafa Levent İnce
Turkish Journal of Medical Sciences
The effects of the administration of a single dose of garlic on the aerobic performance of college endurance athletes were investigated in this study. Ten trained male athletes participated voluntarily in this study. A 900-mg dose of dried garlic powder or placebo was administered randomly in a double-blind cross-over fashion. Five hours after ingestion of the tablets, the subjects underwent an incremental treadmill running test according to the Bruce protocol until subjective exhaustion. During the test, blood pressure and heart rate were monitored at 3 min intervals. After a one-week wash out period, the subjects were crossed over and the …
Antiphospholipid Autoantibodies In Depressive Disorders, Nazan Aydin, Esi̇n Aktaş, Ali̇ Çayköylü, İsmet Kirpinar, R. Ali̇ Sari
Antiphospholipid Autoantibodies In Depressive Disorders, Nazan Aydin, Esi̇n Aktaş, Ali̇ Çayköylü, İsmet Kirpinar, R. Ali̇ Sari
Turkish Journal of Medical Sciences
Higher titers of autoantibodies have been reported in recent studies of depressed patients. In an attempt to investigate the presence of antiphospholipid autoantibodies in patients with depression, sera from both patients and healthy controls were tested for immunoglobulin G and M anticardiolipin and antiphosphatidylserine autoantibodies. We tested positive sera for antiphosphatidylserine (APSA) and anticardi- olipin autoantibody (ACA) in 10 dysthymic, 19 major depressive, and 20 healthy subjects. Tests for ACA-IgM were found to be positive in 1 of the dysthymic patients, in 1 of the major depressives and 1 member of the control group. Positive ACA-IgG was found in 1 …
The Importance Of Anticardiolipin Antibody And Antiplatelet Antibody In The Development Of Thrombocytopenia In Cirrhosis, Hasan Yavuz, Tülay Saricam, Zafer Gülbaş, Ayşegül Özakyol, Eser Vardareli̇, Esat Erenoğlu
The Importance Of Anticardiolipin Antibody And Antiplatelet Antibody In The Development Of Thrombocytopenia In Cirrhosis, Hasan Yavuz, Tülay Saricam, Zafer Gülbaş, Ayşegül Özakyol, Eser Vardareli̇, Esat Erenoğlu
Turkish Journal of Medical Sciences
Objective: The purpose of the present study was to investigate the effects of the presence of hypersplenism, antiplatelet antibody and anticardiolipin antibody, which are thought to be important factors, on the development of thrombocytopenia in patients with cirrhosis with viral etiology. Methods: This study includes 44 patients with cirrhosis related to HBV and HCV, and 12 healthy control subjects. Spleen size was evaluated by ultrasonography, the presence of antiplatelet antibody by flow cytometry, and IgG and IgM isotypes of anticardiolipin anti- body by enzyme immunoassay. Results: There was a significant difference in ultrasonographic spleen size between the patients with and …
Invasiveness Of Radiological Procedures: State-Trait Anxiety In Women Undergoing 3 Different Investigations And 3 Months Follow-Up, Fatma Gül Aksoy, Ayşegül Özdemi̇r, Yasemi̇n Genç
Invasiveness Of Radiological Procedures: State-Trait Anxiety In Women Undergoing 3 Different Investigations And 3 Months Follow-Up, Fatma Gül Aksoy, Ayşegül Özdemi̇r, Yasemi̇n Genç
Turkish Journal of Medical Sciences
Over the past decade, there has been considerable growth in interest in the application of stress management techniques for the preparation of patients needing to undergo noxious medical procedures. Here, we studied state-trait anxiety in women awaiting three different radiological examinations; abdominal ultrasonography, mammography, and hysterosalpingography, which involved various degrees of intrusiveness, and low, intermediate, and high levels of pain and physical/emotional discomfort respectively. We aimed to investigate whether the degree of anxiety corresponded to the level of invasiveness. In addition, we examined the impact of demographic variables on the degree of anxiety and conducted three months of follow-up measurements. …
Possible Microbial Contamination During The Development Of Intra-Oral Films, Rengi̇n Eltem, Hülya Çankaya, Mustafa Ateş, Yasemi̇n Bi̇r
Possible Microbial Contamination During The Development Of Intra-Oral Films, Rengi̇n Eltem, Hülya Çankaya, Mustafa Ateş, Yasemi̇n Bi̇r
Turkish Journal of Medical Sciences
The level of possible microbial cross-contamination in an automatic dental radiograph processor was investigated. Pure cultures of Staphylococcus aureusATCC 6538 P, Escherichia coli ATCC 1103 and Candida utilis ATCC 18804 and a mixed culture of these three microorganisms were prepared. In the first five days of the week, 90 films contaminated with one of these pure cultures were developed. This was followed by the processing of 36 uncontaminated films that were developed in the last two days of the week. The same procedure was repeated for the remaining two pure and mixed microbial cultures. During the study, microbial samples were …
Detection Of Cystic Fibrosis \Deltaf508 Mutation In The Çukurova Region, T. Cevat İnal, Güneş Yüregi̇r, Güler Özer, Bi̇lgi̇n Yüksel
Detection Of Cystic Fibrosis \Deltaf508 Mutation In The Çukurova Region, T. Cevat İnal, Güneş Yüregi̇r, Güler Özer, Bi̇lgi̇n Yüksel
Turkish Journal of Medical Sciences
No abstract provided.
Breast Carcinoma Showing Neuroendocrine Differentiation Characterized With Ectopic Hormone Production (2 Case Reports), Gülay Özbi̇li̇m, Bahar Kiliçarslan, Ekmel Tezer, Ayla Büyükkeçe, Melek Üstün, Şeyda Karaveli̇, Nezi̇hi̇ Oygür
Breast Carcinoma Showing Neuroendocrine Differentiation Characterized With Ectopic Hormone Production (2 Case Reports), Gülay Özbi̇li̇m, Bahar Kiliçarslan, Ekmel Tezer, Ayla Büyükkeçe, Melek Üstün, Şeyda Karaveli̇, Nezi̇hi̇ Oygür
Turkish Journal of Medical Sciences
No abstract provided.
Angiomyolipoma In The Breast And Review Of Literature, Murat Alper, Nusret Akyürek, Süleyman Balkanli, Osman Yüksel
Angiomyolipoma In The Breast And Review Of Literature, Murat Alper, Nusret Akyürek, Süleyman Balkanli, Osman Yüksel
Turkish Journal of Medical Sciences
No abstract provided.
Preparation Of Phbv Foams And Investigation Oftheir Potential For Drug Release, Di̇lek Şendi̇l, İhsan Gürsel, Vasif Hasirci
Preparation Of Phbv Foams And Investigation Oftheir Potential For Drug Release, Di̇lek Şendi̇l, İhsan Gürsel, Vasif Hasirci
Turkish Journal of Medical Sciences
Polymeric foams seem to have potential for use in many research areas such as cell seeding and macromolecule or drug loading. Three factors were studied to evaluate the efficiency of foams as drug carrier and releasing agents. Effect of polymeric properties was examined by using two types of polymers (PHBV 7 and PHBV 22) differing only in their valerate (copolymer) content. The other factor studied was the effect of loading extent on release kinetics and rate. The results showed an unexpected inverse proportionality between drug loading and release rate. They, however, were in accordance with foam physical properties such as …
The Role Of Pr Otein Synthesis In The Adhesion Ofchinese Hamster Lung Cells, Ali̇ Yildirim
The Role Of Pr Otein Synthesis In The Adhesion Ofchinese Hamster Lung Cells, Ali̇ Yildirim
Turkish Journal of Medical Sciences
In order to determine the effect of endogenous protein synthesis on CHL cell adhesion, the initial attachment of these cells to tissue culture dishes was measur ed in the pr esence of 1µgml -1 emetine, in which protein synthesis was inhibited by 97% as determined by labeling the cells with [ 3 5 S]-methio-nine. In the pr esence of this drug, 80% of cells were able to adhere after 2 hours of incubation at 37 o C, while, during the same period, 97% of the contr ol cells became attached. Cells str engthen their adhesion foll owinginitial attachment, spreading and …
Effects Of Acute Grayanotoxin-I Administrationon Hepatic And Renal Functions In Rats, Meral Aşçioğlu, Çi̇ğdem Özesmi̇, Paki̇ze Doğan, Fi̇ngen Öztürk
Effects Of Acute Grayanotoxin-I Administrationon Hepatic And Renal Functions In Rats, Meral Aşçioğlu, Çi̇ğdem Özesmi̇, Paki̇ze Doğan, Fi̇ngen Öztürk
Turkish Journal of Medical Sciences
The effects of acute Grayanotoxin-I (GTX-I) administration on hepatic and renal functions in rats were investigated. GTX-I was administrated to the animals of groups 1, 2 and 3 at a single i.p. dose of 1 mg/kg, 0.5 mg/kg and 0.25 mg/kg respectively, and group 4 (control) received i.p. saline (0.9 %) solution only. One hour following the administration of GTX-I or saline, urine analysis (leukocytes, urobilinogen, protein, pH, blood, ketone, glucose, nitrites) was performed and serum was evaluated for activities of glutamic pyruvic transaminase (GPT), \gamma-glutamyl transferase (\gamma-GT) and isoenzymes of lactate dehydrogenase (LDH) (as a percentage of total LDH …
The Effect Of Iron Bound Transferrin Onmegakaryocytopoiesis In Bone Marrow Culture, Selda Deli̇orman, Ruhi̇ Uyar, Yilmaz Altuner
The Effect Of Iron Bound Transferrin Onmegakaryocytopoiesis In Bone Marrow Culture, Selda Deli̇orman, Ruhi̇ Uyar, Yilmaz Altuner
Turkish Journal of Medical Sciences
Megakaryocytopoiesis is a complicated phenomenon which involves the proliferation of progenitor cells, formation of a polyploid nucleus, cytoplasmic changes and formation of thrombocytes. It has been suggested that megakaryocytopoiesis resembles erythropoiesis. It is well known that iron is a required element for the proliferation of erythrocytes, lymphocytes and cancer cells but no consensus has yet been reached about its role in thrombocytopoiesis. Although thrombocytosis is generally found in patients with iron deficiency anemia, thrombocytopenia is also observed. Cell surface receptors for transferrin were initially characterized on cells with high iron requirements including hemoglobin producing cells and placental cells. More recently, …
Determinants Of Birth Weight: Does Air Pollutionhave An Influential Effect?, Selda Hizel, Turgay Coşkun
Determinants Of Birth Weight: Does Air Pollutionhave An Influential Effect?, Selda Hizel, Turgay Coşkun
Turkish Journal of Medical Sciences
To investigate the influence of air pollution on birth weight, information on maternal and infant characteristics was collected from 458 mothers of infants less than one year of age born in 1995 and under observation at a mother and child health center in Ankara. In addition, the obstetrical histories of 520 infants born in 1990 were collected from the delivery room records of a maternity hospital. Daily air pollution data were obtained and mean monthly values were used for statistical analysis. Among the possible risk factors, sex, maternal age, maternal employment, paternal employment and parity were found to be influential …
Autoimmune Hepatitis In Children: A Report Often Cases, Aydan Kansu, Ayhan Gazi̇ Kalayci, Buket Altuntaş, Tümay Doğanci, Nurten Gi̇rgi̇n
Autoimmune Hepatitis In Children: A Report Often Cases, Aydan Kansu, Ayhan Gazi̇ Kalayci, Buket Altuntaş, Tümay Doğanci, Nurten Gi̇rgi̇n
Turkish Journal of Medical Sciences
Clinical and laboratory features and the outcome of ten cases (nine female, one male) (age range 7-14 years, mean 10.7±2.2 years) with autoimmune hepatitis are described. The diagnosis was established by the laboratory features of elevated serum transferases, hypergammaglobulinemia, presence of autoantibodies, liver histology, excluding viral and metabolic etiologies and by a prompt response to corticosteroid therapy. One patient was associated with celiac disease. Chronic active hepatitis was present histologically in seven children while in three, cirrhosis with portal hypertension had already been established. All patients received steroids. Azathioprine was instituted in three patients in addition to steroid therapy. The …
Small-Dose Fentanyl In Intravenous Versusepidural Preemptive Analgesia, Si̇bel Bariş, Bi̇nnur Sarihasan, Deni̇z Karakaya, Fuat Güldoğuş, Ayla Tür
Small-Dose Fentanyl In Intravenous Versusepidural Preemptive Analgesia, Si̇bel Bariş, Bi̇nnur Sarihasan, Deni̇z Karakaya, Fuat Güldoğuş, Ayla Tür
Turkish Journal of Medical Sciences
In this randomized, double-blinded study, the preemptive effects of intravenous and epidural fentanyl analgesia were compared with post-incisional analgesia in 40 patients undergoing orthophedic surgery of the lower extremities. Patients were randomly allocated to one of two groups; intravenous or epidural analgesia, with twenty patients in each group. General anesthesia was induced with thiopentone 5-6 mgkg -1 and maintained with 0.8-1.0% isoflurane and 66% nitrous oxide in 33% O 2 . The trachea was intubated after administration of vecuronium 0.1 mgkg -1 . Patients in the epidural analgesia groups then received, by random allocation, 2 µgkg -1 fentanyl with 0.9% …
Hydatid Disease Of The Liver: Spontaneousrupture Of The Portal Vein Into The Cyst Wall (Arare Complication), Nusret Akyürek, Erdal Kayhan, Mustafa Kerek
Hydatid Disease Of The Liver: Spontaneousrupture Of The Portal Vein Into The Cyst Wall (Arare Complication), Nusret Akyürek, Erdal Kayhan, Mustafa Kerek
Turkish Journal of Medical Sciences
No abstract provided.
The Role Of Renin-Angiotensin System Inregulating Fibrinolytic Balance: Potentialmechanism In Prevention Of Myocardialinfarction, Mehmet Ağirbasli, Douglas E. Vaughan
The Role Of Renin-Angiotensin System Inregulating Fibrinolytic Balance: Potentialmechanism In Prevention Of Myocardialinfarction, Mehmet Ağirbasli, Douglas E. Vaughan
Turkish Journal of Medical Sciences
No abstract provided.
Preparation Of Bovine Serum Albuminmicrospheres Containing Dexamethasone Sodiumphosphate And The In Vitro Evaluation, Hakan Eroğlu, H. Süheyla Kaş, Levent Öner, Mustafa Sargon, A. Ati̇lla Hincal
Preparation Of Bovine Serum Albuminmicrospheres Containing Dexamethasone Sodiumphosphate And The In Vitro Evaluation, Hakan Eroğlu, H. Süheyla Kaş, Levent Öner, Mustafa Sargon, A. Ati̇lla Hincal
Turkish Journal of Medical Sciences
Dexamethasone sodium phosphate (DSP) is the most common corticosteroid used in the treatment of edema paired with brain tumors (1, 2). As with other corticosteroids, DSP has some adverse effects on the cardiovascular, immune and nervous systems. The objective of this study was to minimize the adverse effects of DSP and to extend the release time of the drug from microspheres by encapsulating with Bovine Serum Albumin (BSA). The microspheres were prepared by emulsion polymerization. An aqueous solution of glutaraldehyde (25% w/v) was used as the crosslinking agent in two different amounts. The release time DSP was found to be …
Analysis Of K-Ras Oncogene Codon 12 Mutationsin A Series Of Human Lung Cancers, Fahri̇ye Demi̇rağ, Erol Atalay, Wayne E. Criss
Analysis Of K-Ras Oncogene Codon 12 Mutationsin A Series Of Human Lung Cancers, Fahri̇ye Demi̇rağ, Erol Atalay, Wayne E. Criss
Turkish Journal of Medical Sciences
Lung cancer is the major cancer in Turkey; 45% of the deaths due to cancer in Turkish males are from lung cancer. There are 8 histopathological types of lung cancer, and most types have several genomic/genetic alterations, including amplification of oncogenes. The current study evaluated the ras oncogene in human lung cancers from Turkish patients. Thirty-six normal and pathological lung tissue specimens were obtained from patients with chest disease during surgery, frozen at -86°C, and processed within 2-3 months. Mutations in K-ras, codon 12 were analyzed using a series of DNA purification proceedures, polymerase chain reaction amplification, and dot-blotting techniques. …