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Articles 421 - 450 of 8080
Full-Text Articles in Medicine and Health Sciences
Preoperative Parent Education And Postoperative Nurse-Led Care For Boys Versus Routine Hospital Care For Urethroplasty For Hypospadias In Western China: A Retrospective Study, Lisi Wang, Zhengdong Wang, Xiaohui Mao, Yingjun Fu, Qian Lei, Qin Liao
Preoperative Parent Education And Postoperative Nurse-Led Care For Boys Versus Routine Hospital Care For Urethroplasty For Hypospadias In Western China: A Retrospective Study, Lisi Wang, Zhengdong Wang, Xiaohui Mao, Yingjun Fu, Qian Lei, Qin Liao
Turkish Journal of Medical Sciences
Background/aim: Urethroplasty is the preferred treatment for hypospadias but is affected by the severity of anomalies, making it a complex procedure with potential postoperative complications. Following surgery, parents receive instructions and recommendations, whether from nurses or physicians, regardless of complication rates. However, nurses play a crucial role in educating caregivers before surgery and providing postoperative care during follow-up. The study aims to assess parents’ knowledge and practices, as well as the frequency of complications in boys who underwent urethroplasty for hypospadias and received postoperative nurse-led care and whose parents received preoperative education against those of boys who underwent urethroplasty under …
The Effect Of Human Recombinant Epidermal Growth Factor On Neovascularization And Pedicle Division Time In A Rat Interpolation Flap Model, Aziz Parspanci, Yavuz Keçeci̇, Peyker Temi̇z
The Effect Of Human Recombinant Epidermal Growth Factor On Neovascularization And Pedicle Division Time In A Rat Interpolation Flap Model, Aziz Parspanci, Yavuz Keçeci̇, Peyker Temi̇z
Turkish Journal of Medical Sciences
Background/aim: In practice, waiting 2–3 weeks for interpolation flaps pedicle division result in certain morbidities and discomfort for patient. The division time of flap pedicle depends on neovascularization from the recipient bed and includes wound healing stages. We aimed to investigate the effect of recombinant human epidermal growth factor (rhEGF) on the flap viability during early pedicle division.Materials and methods: Thirty-six rats were allocated to two main groups as control and study. A cranial based flap measuring 5 × 5 cm was elevated from the back, including all layers of the skin. While the cranial half of the defect was …
Evaluation Of Smoking Cessation Counseling Practices Of Physicians Working In Primary Health Care Institutions, Fatma Nur Karaçorlu, Edibe Pi̇ri̇nçci̇
Evaluation Of Smoking Cessation Counseling Practices Of Physicians Working In Primary Health Care Institutions, Fatma Nur Karaçorlu, Edibe Pi̇ri̇nçci̇
Turkish Journal of Medical Sciences
Background/aim: In this study, we aimed to evaluate the self-reported practice of physicians working in primary health care institutions in Elazığ Province about smoking cessation counseling.Materials and methods: The population of this cross-sectional study consisted of 262 physicians working in primary health care institutions in Elazığ. We aimed to reach the entire population without using the sample selection method and we successfully reached 95.42% (250 people) of the population. A questionnaire form was used for data collection. The data obtained were evaluated by frequency, percentage, mean ± standard deviation, median and minimum–maximum, and binary logistic regression analysis.Results: The mean age …
Internal Mucosal Resection And Llc Suspension: A New Method To Establish A Stable Tip Rotation Angle And Reduce The Nasal Bridge Length, Mehmet Dadaci, Moath Zuhour, Bilsev İnce, Zeynep Altuntaş
Internal Mucosal Resection And Llc Suspension: A New Method To Establish A Stable Tip Rotation Angle And Reduce The Nasal Bridge Length, Mehmet Dadaci, Moath Zuhour, Bilsev İnce, Zeynep Altuntaş
Turkish Journal of Medical Sciences
Background/aim: Herein, we describe a new technique to obtain both the appropriate degree of rotation angle and the ideal nasal bridge length. The aim of this study is to investigate the long-term results of this new technique with regard to these two variables.Materials and methods: A total of 76 (27 males, 49 females) patients were operated in accordance with the presented technique. Internal caudal mucosal excision and lower lateral cartilage (LLC) suspension were applied to all the patients included in this prospective study. Preoperative, immediate postoperative, and postoperative 1st-year photographs were taken. NOSE scores were obtained in the postoperative 1st …
Small Airway Resistance In Obese And Nonobese Patients With Obstructive Sleep Apnea Syndrome Using Impulse Oscillometry, Nejdiye Güngördü, Aytan İsmayi̇lova, Nigar Ali̇yeva, Tamer A M Alhelou, Ayşenur Özdi̇l Eser, Ilgım Vardaloğlu Koyuncu, Nihal Enşen, Ersan Atahan, Şermin Börekçi̇, Bilun Gemi̇ci̇oğlu
Small Airway Resistance In Obese And Nonobese Patients With Obstructive Sleep Apnea Syndrome Using Impulse Oscillometry, Nejdiye Güngördü, Aytan İsmayi̇lova, Nigar Ali̇yeva, Tamer A M Alhelou, Ayşenur Özdi̇l Eser, Ilgım Vardaloğlu Koyuncu, Nihal Enşen, Ersan Atahan, Şermin Börekçi̇, Bilun Gemi̇ci̇oğlu
Turkish Journal of Medical Sciences
Background/aim: There is limited information on the pathologic changes in the small airways among obese and nonobese patients with obstructive sleep apnea syndrome (OSAS). Impulse oscillometry (IOS) measures airway resistance and reactance independently of patient effort. This study aimed to compare airway resistance in small airways using IOS between obese and nonobese patients with OSAS.Materials and methods: In this real-life cross-sectional study, demographic information was collected from obese and nonobese subjects diagnosed with moderate and severe OSAS without any other underlying diseases. Spirometry and IOS measurements were conducted, and the values of both groups were statistically analyzed.Results: The nonobese group …
Alterations In Serum Thiol-Disulfide Homeostasis And Ischemia-Modified Albumin Concentrations In Clinical Canine Parvoviral Enteritis, Yasi̇n Şenel, Osman Safa Terzi̇, Erdal Kara, Özcan Erel, Sali̇m Neşeli̇oğlu, Ebubeki̇r Ceylan
Alterations In Serum Thiol-Disulfide Homeostasis And Ischemia-Modified Albumin Concentrations In Clinical Canine Parvoviral Enteritis, Yasi̇n Şenel, Osman Safa Terzi̇, Erdal Kara, Özcan Erel, Sali̇m Neşeli̇oğlu, Ebubeki̇r Ceylan
Turkish Journal of Veterinary & Animal Sciences
Monitoring biomarkers related to inflammation and oxidative stress is critical in dogs because parvovirus causes both inflammatory and antioxidant alterations. The aim of this study was to investigate inflammatory and antioxidant changes caused by canine parvoviral enteritis to better understand the oxidative stress process related to this disease. Thus, the total thiol, native thiol, disulfide, and ischemia-modified albumin levels of Canine parvovirus infected symptomatic puppies and healthy puppies were examined. Using the results of complete blood counts, the blood serum thiol-disulfide homeostasis and ischemia modified albumin levels of the puppies with Canine parvoviral enteritis (n = 65) and the healthy …
Determination Of Antibiotic Resistance In Salmonella Typhimurium And Salmonella Kentucky Serotypes Of Animal Origin Using Conventional And Molecular Methods, Zeynep Şik, Mehmet Akan
Determination Of Antibiotic Resistance In Salmonella Typhimurium And Salmonella Kentucky Serotypes Of Animal Origin Using Conventional And Molecular Methods, Zeynep Şik, Mehmet Akan
Turkish Journal of Veterinary & Animal Sciences
The high incidence of multidrug-resistant Salmonella Typhimurium and Salmonella Kentucky isolates is a concern for human and animal health. This study aimed to investigate the antibiotic resistance determinants of a total of 150 S. Typhimurium and S. Kentucky isolates obtained from cows, calves, lambs, and poultry. Salmonella isolates were tested against 13 different antimicrobials using the Kirby-Bauer disc diffusion method, and genotypic antimicrobial resistance determinants were investigated by polymerase chain reaction. Significant differences were detected among serovars for gentamicin, streptomycin, ampicillin, sulfonamide, nalidixic acid, ciprofloxacin, and tetracycline resistance, with the rates of resistance to these antibiotics being determined to be …
The Effect Of Artificial Insemination Catheters Covered With Protective Sheaths On Conception Rates In Heifers, Berrak Işık Soytürk, Hüseyin Erdem
The Effect Of Artificial Insemination Catheters Covered With Protective Sheaths On Conception Rates In Heifers, Berrak Işık Soytürk, Hüseyin Erdem
Turkish Journal of Veterinary & Animal Sciences
Artificial insemination is a biotechnological method widely practiced in cattle, first introduced in 1912. The present study investigated the effect of pierceable plastic sheaths used during artificial insemination of Holstein heifers on conception rates. A total of 110 heifers aged 15–18 months, detected to be in estrus based on observation, were included in the study. These heifers were randomly divided into two equal groups. The experimental group (n = 55) underwent insemination using an insemination catheter covered with a disposable, pierceable plastic sheath on day 0. Conversely, the control group (n = 55) underwent insemination using the standard conventional technique. …
Comparison Of Milk Microbiota Between Healthy And Mastitic Cows, Sibel Kizil, Fatma Esin Aydin, Cansu Önlen Güneri̇, Ufuk Ülker, Gürol Emekdaş, İbrahim Basmaci, Serkan Erat, Rıza Durmaz, Efsun Melike Çeçen, Asya Kazan
Comparison Of Milk Microbiota Between Healthy And Mastitic Cows, Sibel Kizil, Fatma Esin Aydin, Cansu Önlen Güneri̇, Ufuk Ülker, Gürol Emekdaş, İbrahim Basmaci, Serkan Erat, Rıza Durmaz, Efsun Melike Çeçen, Asya Kazan
Turkish Journal of Veterinary & Animal Sciences
Mammary gland infections occur due to bacterial changes in the mammary tissue. Studies conducted in recent years have reported variations in the most common bacteria differ according to geographical locations. California mastitis test (CMT), somatic cell count (SCC), and aerobic colony count (ACC) analyses were performed on approximately 50 mL of hygienically collected raw milk samples. Raw milk was also subjected to conventional bacteriological isolation and identification. Bacterial diversity and rates in raw milk were compared through metagenome analysis. Two samples, one from healthy milk and another from subclinical milk with mastitis, were independently tested to determine whether there were …
Determination Of Some Environmental Factors On Milk Yield Traits And Milk Components In Simmental Cows, Onur Şahi̇n, Mehmet İhsan Soysal, Eser Kemal Gürcan
Determination Of Some Environmental Factors On Milk Yield Traits And Milk Components In Simmental Cows, Onur Şahi̇n, Mehmet İhsan Soysal, Eser Kemal Gürcan
Turkish Journal of Veterinary & Animal Sciences
The aim of the study was to determine the effects of various environmental factors on milk yield and milk components in Simmental cows. In the present study, 33,813 milk yield records from 1631 cows and milk samples from 233 cows were used for milk component analysis. Lactation milk yield (LMY) and 305-day yield (305-DMY) were the milk yield characteristics studied. Environmental factors considered for milk yield characteristics included province, calving year, calving month, parity, age, and lactation length. Milk components analyzed were fat percentage (FP), protein percentage (PP), lactose percentage (LP), somatic cell count (Log10SCC), and dry matter (DM). Environmental …
Investigation Of Molecular Detection Rate And Associated Risk Factors Of Psittacine Beak And Feather Disease Virus In Psittaciformes In Iran, Mojtaba Khosravi, Shoreh Alian Samakkhah, Rahem Khoshbakht
Investigation Of Molecular Detection Rate And Associated Risk Factors Of Psittacine Beak And Feather Disease Virus In Psittaciformes In Iran, Mojtaba Khosravi, Shoreh Alian Samakkhah, Rahem Khoshbakht
Turkish Journal of Veterinary & Animal Sciences
Psittacine beak and feather disease virus (PBFDV) is a significant viral pathogen affecting the development of beak and feather cells, leading to feather abnormalities in avian species. This study aimed to investigate the molecular detection rate of PBFDV among Psittaciformes in Iran and to evaluate the influence of factors such as sex, species, season, and bird origin on PBFDV prevalence. Feather samples were collected from 1335 Psittaciformes, including Agapornis roseicollis, Pyrrhura molinae, Myiopsitta monachus, Aratinga solstitialis, Nymphicus hollandicus, Psittacula krameri, Psittacus erithacus, Poicephalus senegalus, Eos bornea, and Agapornis fischeri, and subjected to polymerase chain reaction (PCR) for PBFDV detection. The …
The Effect Of Housing Environment (Deep Litter With Or Without Access To Different Plant Species Outdoor) On Welfare And Behavior Across Two Strains Of Laying Hens, Brian Tainika, Ahmet Şekeroğlu, Ahmet Akyol, Samet Hasan Abaci, Fatih Mehmet Gür
The Effect Of Housing Environment (Deep Litter With Or Without Access To Different Plant Species Outdoor) On Welfare And Behavior Across Two Strains Of Laying Hens, Brian Tainika, Ahmet Şekeroğlu, Ahmet Akyol, Samet Hasan Abaci, Fatih Mehmet Gür
Turkish Journal of Veterinary & Animal Sciences
The impact of housing environment and strain on welfare and behavior of laying hens was the focus of this study. Lohmann LSL Classic (W) and Lohmann Sandy (S) were assessed under deep litter without outdoor access (DL), deep litter with access to outdoor pens covered with either Mentha piperita (MP), Petroselinum crispum (PC) or Medicago sativa (MS). Duration of tonic immobility, feather condition, footpad dermatitis, and temperatures (comb, breast region, footpad surface, and rectal) were determined at 31, 42, and 52 weeks of age. Hen`s behaviors were observed at 32, 42, and 52 weeks of age. Blood parameters were assessed …
Comparison Of Nonlinear Models For Predicting Live Weight Growth Curves In Lambproduction Of Kıvırcık And Karacabey Merino, Vasfi̇ye Kader Esen, Orhan Karadağ, Cengi̇z Elmaci, Seli̇m Esen
Comparison Of Nonlinear Models For Predicting Live Weight Growth Curves In Lambproduction Of Kıvırcık And Karacabey Merino, Vasfi̇ye Kader Esen, Orhan Karadağ, Cengi̇z Elmaci, Seli̇m Esen
Turkish Journal of Veterinary & Animal Sciences
To achieve sustainable lamb production, it is crucial to determine the optimal slaughter age for maximum economic efficiencyand have a comprehensive understanding of breed characteristics. This study focuses on evaluating different nonlinear models todetermine the optimal slaughter age for Karacabey Merino and Kıvırcık lambs, renowned for their early development and superiormeat quality, respectively. The dataset comprised age-related live weight data from 98 lambs, including 36 female and 15 male Kıvırcıklambs, as well as 33 female and 14 male Karacabey Merino lambs. Six models, namely, negative exponential, Brody, Gompertz, logistic,Bertalanffy, and Richards were utilized to analyze the data. The model parameters …
Minimally Invasive Sacroiliac Fusion; Current Insights And A Comprehensive Literature Review, Aydin Apaydin, Mehmet Yurtluk, Khoi̇ Than
Minimally Invasive Sacroiliac Fusion; Current Insights And A Comprehensive Literature Review, Aydin Apaydin, Mehmet Yurtluk, Khoi̇ Than
Turkish Journal of Medical Sciences
The sacroiliac joint (SIJ) is an easily dismissable cause of lower back pain (LBP). Recently has gained attention as the source of pain and surgeries addressing this issue have gained attention among surgeons. Classically open fusion surgery was used for the pelvic and sacral fractures to stabilize the structure and then open SIJ fusion surgery started to be used for pain management until the discovery of minimally invasive surgery (MIS). MIS offered fast and effective pain relief with significantly less risk of adverse events following the surgery. Therefore gaining more and more attention each day among surgeons. Our literature review …
Evaluating The Performance Of The Mskcc Gastric Cancer Survıval Calculator In The Turkısh Population, İlknur Deli̇ktaş Onur, Tuğba Başoğlu Tüylü, Nazim Demi̇rcan, Tuğba Akin Telli̇, Ruki̇ye Arikan, Özlem Ercelep, Serdar Turhal, Mehmet Öztürk, Perran Yumuk, Faysal Dane
Evaluating The Performance Of The Mskcc Gastric Cancer Survıval Calculator In The Turkısh Population, İlknur Deli̇ktaş Onur, Tuğba Başoğlu Tüylü, Nazim Demi̇rcan, Tuğba Akin Telli̇, Ruki̇ye Arikan, Özlem Ercelep, Serdar Turhal, Mehmet Öztürk, Perran Yumuk, Faysal Dane
Turkish Journal of Medical Sciences
Bacground/Aim: The MSKCC(Memorial Sloan Kettering Cancer Center) nomogram was developed to predict survivorship in gastric cancer patients undergoing R0 resection. This study aimed to evaluate the predictive power of this nomogram in the Turkish patient population. Materials and Methods: Gastric cancer patients over 18 years of age who were admitted to our clinic between 2000 and 2019 and underwent primary curative surgery and R0 resection were included in the study. The 5-year and 9-year overall survival rates of 489 patients were analyzed. Real-life survival rates and those calculated with the MSKCC tool were compared in all patients and subgroups. The …
Association Between Papillary Thyroid Cancer And Xrcc6 Gene Polymorphisms In The Turkish Population, Egemen Akgün, Fadi̇me Mutlu İçduygu, Demet Şengül, Ebru Alp, Mehmet Alkanat, Aysegül Cebi̇, Tuncer Ozturk
Association Between Papillary Thyroid Cancer And Xrcc6 Gene Polymorphisms In The Turkish Population, Egemen Akgün, Fadi̇me Mutlu İçduygu, Demet Şengül, Ebru Alp, Mehmet Alkanat, Aysegül Cebi̇, Tuncer Ozturk
Turkish Journal of Medical Sciences
Background/aim: This study aims to investigate the association between rs2267437, rs5751129 and rs132770 polymorphisms of the XRCC6 gene, which plays a role in repairing DNA double strand breaks, and the risk of Papillary Thyroid Cancer (PTC).Methods: The study included 150 patients who had been diagnosed with PTC and 204 healthy control subjects. Genotyping of SNPs was performed by Polymerase Chain Reaction - Restriction Fragment Length Polymorphism method (PCR - RFLP).Results: In rs2267437 polymorphism, individuals with GG genotype had lower risk of PTC than wild-type CC genotype (p=0.037, 95% CI=0.19-0.96, OR=0.67). The combined genotypes CG+GG were found to be related to …
Reliability And Validity Of The Turkish Version Of The Infant Motor Activity Log In Infants With Upper Extremity Functional Asymmetry: How Often And How Well?, Kübra Seyhan Biyik, Cemi̇l Özal, Kivanç Deli̇oğlu, Mi̇ntaza Kerem Günel
Reliability And Validity Of The Turkish Version Of The Infant Motor Activity Log In Infants With Upper Extremity Functional Asymmetry: How Often And How Well?, Kübra Seyhan Biyik, Cemi̇l Özal, Kivanç Deli̇oğlu, Mi̇ntaza Kerem Günel
Turkish Journal of Medical Sciences
Background/aim: Functional asymmetry in the upper extremities may occur in infants with neuromotor problems due to neurodevelopmental or musculoskeletal disorders. The aim of this study was to investigate the validity and reliability of the Turkish version of the Infant Motor Activity Log Scale (IMAL-T), which asks about the frequency (how often) and quality (how well) of the affected arm usage during activities in infants with functional asymmetry in the upper extremities.Materials and methods: The IMAL-T was administered face-to-face to parents of 102 infants (60 infants at high risk of cerebral palsy (CP) and 42 infants with brachial plexus birth injury …
Evaluation Of The Association Of Mucosa-Associated Invariant T (Mait) Cells With Childhood Asthma, Meral Ekşi̇, Huri̇ Bulut, Erdem Akalin, Feyza Ustabaş Kahraman, Hakan Yazan, Mebrure Yazici, Mustafa Nursoy, Emi̇n Özkaya, Abdürrahi̇m Koçyi̇ği̇t, Erkan Çakir
Evaluation Of The Association Of Mucosa-Associated Invariant T (Mait) Cells With Childhood Asthma, Meral Ekşi̇, Huri̇ Bulut, Erdem Akalin, Feyza Ustabaş Kahraman, Hakan Yazan, Mebrure Yazici, Mustafa Nursoy, Emi̇n Özkaya, Abdürrahi̇m Koçyi̇ği̇t, Erkan Çakir
Turkish Journal of Medical Sciences
Background/aim: Innate-like T lymphocytes are a recently defined group of T cells comprising mainly mucosa-associated invariant T (MAIT) cells. The relationship between MAIT cells and childhood asthma is controversial. In this study, we aimed to determine the role of MAIT cells in patients with allergic asthma (AA) and nonallergic asthma (NAA). This is the first study to compare the ratios of these cells in patients with AA and NAA.Materials and methods: The study included children aged 6–18 years with AA (n = 41) or NAA (n = 30) and healthy control subjects (n = 36). The control group consisted of …
Clinicopathological Features For The Prediction Of Immunosuppressive Treatment Responses In Sarcoidosis-Related Kidney Involvement: A Single-Center Retrospective Study, Ahmet Burak Di̇ri̇m, Vafa Suleymanova, Ozge Hurdogan, Özgür Oto, Ayşe Artan, Savas Ozturk, Yasemi̇n Ozluk, Isi̇n Ki̇li̇caslan, Hali̇l Yazi̇ci̇
Clinicopathological Features For The Prediction Of Immunosuppressive Treatment Responses In Sarcoidosis-Related Kidney Involvement: A Single-Center Retrospective Study, Ahmet Burak Di̇ri̇m, Vafa Suleymanova, Ozge Hurdogan, Özgür Oto, Ayşe Artan, Savas Ozturk, Yasemi̇n Ozluk, Isi̇n Ki̇li̇caslan, Hali̇l Yazi̇ci̇
Turkish Journal of Medical Sciences
Background/aim: Sarcoidosis is a multisystem disorder that affects many organs, including the kidneys. This single-center retrospective study investigated the clinical, pathological, and laboratory findings of patients with kidney sarcoidosis who were treated with immunosuppressives.Materials and Methods: Twenty-three patients with biopsy-confirmed kidney sarcoidosis were included. Demographics, clinical, pathological, and laboratory findings, in addition to treatments, and outcomes of twenty patients with at least one month of follow-up were evaluated.Results: Median age at the time of biopsy was 47 years(60.9 % female). Median baseline eGFR and proteinuria were 21.5 ml/min and 1 g/g or g/day, respectively. Nineteen of the 23 patients were …
Comparison Of Classical Methods For Bone Age Determination With Capitohamate Planimetry On Wrist X-Rays, Hasan Yildiz, Nadi̇re Ünver Doğan, Mehmet Öztürk, Zeli̇ha Fazlioğullari, Muslu Körez, Ahmet Karabulut
Comparison Of Classical Methods For Bone Age Determination With Capitohamate Planimetry On Wrist X-Rays, Hasan Yildiz, Nadi̇re Ünver Doğan, Mehmet Öztürk, Zeli̇ha Fazlioğullari, Muslu Körez, Ahmet Karabulut
Turkish Journal of Medical Sciences
Background/aim: This study aims to compare the Greulich–Pyle (GP) and Tanner–Whitehouse 2 (TW2) methods, both used in left wrist radiography for bone age determination in the pediatric age group, with the Capitohamatum method (CH) due to the importance of determining bone age in the pediatric period.Materials and methods: Direct radiographs of 210 female and 291 male individuals between the ages of 0–15 without any pathology in the left wrist bones were obtained; 501 os capitatum and os hamatum on anterior-to-posterior direct graphic images were measured using the GP, TW2, and CH planimetry methods. The estimated age of each measurement was …
Effect Of Δnp63Β On Cell Cycle And Apoptosis In T98g Cells, Buse Turegun Atasoy, Fi̇kret Sahin
Effect Of Δnp63Β On Cell Cycle And Apoptosis In T98g Cells, Buse Turegun Atasoy, Fi̇kret Sahin
Turkish Journal of Medical Sciences
Background/aim: The p53 protein, a crucial tumor suppressor, governs cell cycle regulation and apoptosis. Similarly, p63, a member of the p53 family, exhibits traits of both tumor suppression and oncogenic behavior through its isoforms. However, the functional impact of ΔNp63β, an isoform of the p63 protein, on human glioma cancer cells like T98G cells remains poorly understood, representing the novelty of this study in the current literature.Materials, methods: Employing the pRetroX-Tet-On vector system, we investigated ΔNp63β's apoptotic effects on T98G cell lines and assessed its influence on the cell cycle. Initially, we established a rtTA-expressing vector, a component of the …
Investigating The Biomarker Potential And Molecular Targets Of Tigd1 In Lung Cancer Using Bioinformatics, Merve Gulsen Bal Albayrak, Tuğcan Korak, Murat Kasap, Gurler Akpinar
Investigating The Biomarker Potential And Molecular Targets Of Tigd1 In Lung Cancer Using Bioinformatics, Merve Gulsen Bal Albayrak, Tuğcan Korak, Murat Kasap, Gurler Akpinar
Turkish Journal of Medical Sciences
Background/aimLung cancer, a predominant contributor to cancer mortality, is characterized by diverse etiological factors, including tobacco smoking and genetic susceptibilities. Despite advancements, particularly in non-small cell carcinoma (NSCC), therapeutic options for squamous cell carcinoma (LUSC) are limited. Transposable elements (TE) and their regulatory proteins, such as Transposable element derived (TIGD) family proteins, have been implicated in cancer development. TIGD1, upregulated in various cancers, including LUSC, lacks a defined function. This study aimed to elucidate the biological functions, associated pathways, and interacting proteins of TIGD1.Materials and methodsThe GSE229260 microarray dataset were investigated using GEO2R tool to identify the differentially expressed genes …
Severe Degranulation Of Mesenteric Mast Cells In An Experimental Rat Mammary Tumor Model, Senem Yavaş, Özkan Yavaş, Semi̇ha Ersoy, Gürsel Sönmez
Severe Degranulation Of Mesenteric Mast Cells In An Experimental Rat Mammary Tumor Model, Senem Yavaş, Özkan Yavaş, Semi̇ha Ersoy, Gürsel Sönmez
Turkish Journal of Medical Sciences
Background/aim: Breast cancers are one of the most common cancers in women and are responsible for many deaths worldwide. Mast cells are inflammatory cells. Their role in cancers is controversial, and there is limited data on systemic mast cell activation in cancer cases. This study aimed to evaluate systemic mast cell activation in an experimentally induced rat model of breast cancer. Materials and methods: Sprague Dawley female rats were divided into control (n=6) and mammary tumor (n=12) groups. In the tumor group, 20 mg 12-dimethylbenz[a]anthracene (DMBA) dissolved in 1 ml cottonseed oil was administered intragastrically by gavage, and the rats …
In Silico Study Of Bioactive Compounds Derived From Indonesian Marine Invertebrates As Novel Antituberculosis Agent, Ayu Masyita, Eri̇s Septiana, Asep Bayu, Bustanussalam Bustanussalam, Jonathan A. Panggabean, Fi̇rdayani̇ Firdayani, Tuti̇k Murniasih
In Silico Study Of Bioactive Compounds Derived From Indonesian Marine Invertebrates As Novel Antituberculosis Agent, Ayu Masyita, Eri̇s Septiana, Asep Bayu, Bustanussalam Bustanussalam, Jonathan A. Panggabean, Fi̇rdayani̇ Firdayani, Tuti̇k Murniasih
Turkish Journal of Medical Sciences
Background/aim: Tuberculosis has still become the most deadly disease globally. The problem of finding an effective therapeutic is one of the obstacles in the treatment of patients. Marine invertebrates were a treasure since they produced many active compounds. Following up on this issue, screening active compounds is very important. This study will explain the result of anti-tuberculosis screening of compounds derived from marine invertebrates using in silico and confirmed to the in vitro-data.Materials and methods: Three-dimensional (3D) structures of pantothenate kinase (MtPanK type 1, PDB ID: 4BFT), Mycobacterium tuberculosis InhA (MtInhA, PDB ID: 2X23), protein kinase B (PDB ID: 5U94), …
The Role Of Circadian Rhythm Proteins Rev-Erb Α/ And Β In The Development Of Neuronal Injury After Taumatic Brain Injury, Mahmud Pençe, Enes Dogan, Hali̇l Koç, Ci̇gdem Bayraktaroglu, Serdar Altunay, Zeynep Balçikanli, Ertugrul Kiliç, Mustafa Beker
The Role Of Circadian Rhythm Proteins Rev-Erb Α/ And Β In The Development Of Neuronal Injury After Taumatic Brain Injury, Mahmud Pençe, Enes Dogan, Hali̇l Koç, Ci̇gdem Bayraktaroglu, Serdar Altunay, Zeynep Balçikanli, Ertugrul Kiliç, Mustafa Beker
Turkish Journal of Medical Sciences
Background/Aim:Circadian rhythm proteins (CRP) play critical roles in both physiological and pathophysiological conditions, including neurodegenerative disorders. As member of CRP, the nuclear receptors REV-ERBα/β regulates circadian rhythm particularly by inhibiting Bmal1 protein and involved in the neuroinflammation- and cell death processes. However, their roles in the development of neuronal injury after traumatic brain injury (TBI) were largely unexplored, which were investigated in the present study.Materials and Methods: For the induction of TBI, animals were submitted to the cryogenic model of TBI, which is a commonly used animal model and shares essential similarities with cerebral ischemia in terms of pathophysiological cascades. …
Epidemiology Of Heart Failure In Türkiye, Nai̇m Ata, İnci̇ Tuğçe Çöllüoğlu, Anil Şahi̇n, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Şuayi̇p Bi̇ri̇nci̇, Mustafa Mahi̇r Ülgü, Emi̇ne Arzu Kanik, Di̇lek Ural, Lale Di̇nç Asarcikli, Emre Demi̇r, Yüksel Çavuşoğlu, Selda Murat, Ahmet Çeli̇k
Epidemiology Of Heart Failure In Türkiye, Nai̇m Ata, İnci̇ Tuğçe Çöllüoğlu, Anil Şahi̇n, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Şuayi̇p Bi̇ri̇nci̇, Mustafa Mahi̇r Ülgü, Emi̇ne Arzu Kanik, Di̇lek Ural, Lale Di̇nç Asarcikli, Emre Demi̇r, Yüksel Çavuşoğlu, Selda Murat, Ahmet Çeli̇k
Turkish Journal of Medical Sciences
Background/aim:The epidemiological data on heart failure (HF) vary between regions within the same country.We aimed to investigate the epidemiological data on HF in Turkiye across all age groups regarding seven geographical regions.Materials and methods:We included all patients in the Turkish population with a first diagnosis of HF between January 1, 2016 and December, 31 2022, with the use of ICD-10 codes from the National Electronic Healthcare Database.The data were categorized by seven geographical regions of Turkiye.Results:The median age of index diagnosis of HF was 70(60-78) years in all age groups and 4(1-12) years in pediatric population.Prevalence rate of HF was …
Approaching A Nationwide Registry: Analyzing Big Data In Patients With Heart Failure, Tuğçe Çöllüoğlu, Anil Şahi̇n, Ahmet Çeli̇k, Emi̇ne Arzu Kanik
Approaching A Nationwide Registry: Analyzing Big Data In Patients With Heart Failure, Tuğçe Çöllüoğlu, Anil Şahi̇n, Ahmet Çeli̇k, Emi̇ne Arzu Kanik
Turkish Journal of Medical Sciences
Background/aim:Randomized controlled trials usually lack generabilizity to real-world context.Real-world data, enabled by the use of big data analysis, serve as a connection between the results of trials and the implementation of findings in clinical practice.Nevertheless, using big data in the healthcare has difficulties such as ensuring data quality and consistency.This article aimed to examine the challenges in accessing and utilizing healthcare big data for heart failure (HF) research, drawing from experiences in creating a nationwide HF registry in Turkiye.Materials and methods:We established a team including cardiologists, HF specialists, biostatistics experts, and data analysts. We searched certain key words related to …
Diagnostic Approach To Heart Failure In Türkiye, Di̇lek Ural, Lale Di̇nç Asarcikli, İnci̇ Tuğçe Çöllüoğlu, Anil Şahi̇n, Yüksel Çavuşoğlu, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Nai̇m Ata, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇, Selda Murat, Emre Demi̇r, Emi̇ne Arzu Kanik, Ahmet Çeli̇k
Diagnostic Approach To Heart Failure In Türkiye, Di̇lek Ural, Lale Di̇nç Asarcikli, İnci̇ Tuğçe Çöllüoğlu, Anil Şahi̇n, Yüksel Çavuşoğlu, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Nai̇m Ata, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇, Selda Murat, Emre Demi̇r, Emi̇ne Arzu Kanik, Ahmet Çeli̇k
Turkish Journal of Medical Sciences
Background/aim:Final diagnosis of heart failure (HF) relies on a combination clinical findings, laboratory and imaging tests.The aim of this study was to review the diagnostic approach to HF in Turkiye.Materials and methods:This study is a subanalysis of the nationwide TRends-HF study based on anonymized data of National Electronic Database between January 1, 2016, and December 31, 2022.Variables including date of birth, sex, socioeconomic development index, place of initial HF diagnosis, comorbidities, investigations, and diagnostic procedures were reported.Laboratory variables, including complete blood count, natriuretic peptides (NP), estimated glomerular filtration rate, uric acid, electrolytes, albumin, lipid profile, ferritin and hemoglobin A1c levels …
Burden Of Comorbidities In Heart Failure Patients In Türkiye, Yüksel Çavuşoğlu, Selda Murat, Anil Şahi̇n, İnci̇ Tuğçe Çöllüoğlu, Di̇lek Ural, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Nai̇m Ata, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇, Emre Demi̇r, Emi̇ne Arzu Kanik, Lale Di̇nç Asarcikli, Ahmet Çeli̇k
Burden Of Comorbidities In Heart Failure Patients In Türkiye, Yüksel Çavuşoğlu, Selda Murat, Anil Şahi̇n, İnci̇ Tuğçe Çöllüoğlu, Di̇lek Ural, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Nai̇m Ata, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇, Emre Demi̇r, Emi̇ne Arzu Kanik, Lale Di̇nç Asarcikli, Ahmet Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: Heart Failure (HF) is associated with a wide range of comorbidities that negatively impact on clinical outcomes and cause to high economic burden. We aimed to evaluate frequency and burden of comorbidities in HF patients in Türkiye and their relationship with the patient's demographic characteristics.Materials and methods: Based on ICD-10 codes in National Electronic Database of the Turkish Ministry of Health, covering the entire population of Türkiye (n=85,279,553), from January 1, 2016, to December 31, 2022, prevalence of comorbidities in HF patients were obtained. Frequency and burden of comorbidities were analyzed separately by age groups, gender and socioeconomic status …