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Articles 4021 - 4050 of 8080
Full-Text Articles in Medicine and Health Sciences
Tc-99m Mdp Bone Scintigraphy In The Evaluation Of The Joint Damage In Asymptomatic Alpine Ski Racers, Erhan Varoğlu, Mustafa Yildirim, Recep Gürsoy, Bedri̇ Seven, Hati̇ce Uslu, Şi̇rzat Çoğalgi̇l, Fati̇h Kiyici
Tc-99m Mdp Bone Scintigraphy In The Evaluation Of The Joint Damage In Asymptomatic Alpine Ski Racers, Erhan Varoğlu, Mustafa Yildirim, Recep Gürsoy, Bedri̇ Seven, Hati̇ce Uslu, Şi̇rzat Çoğalgi̇l, Fati̇h Kiyici
Turkish Journal of Medical Sciences
To evaluate the role of 99m-technetium methylene diphosphonate (Tc-99m MDP) bone scintigraphy on the detection of joint damage in asymptomatic alpine ski racers. Materials and methods: This study included 20 male asymptomatic alpine ski racers (age range: 18-21 years). None of the skiers had a history of ski crashes. Bone scan findings of the racers were examined with Tc-99m MDP bone scintigraphy during the active racing season and the inactive training season. Planar anterior and posterior images of hip, knee, and ankle joints were obtained 4 h after intravenous injection of 20 mCi Tc-99m MDP. All images were interpreted visually …
Clinical And Prognostic Importance Of Chromosomal Abnormalities, Y Chromosome Microdeletions, And Cftr Gene Mutations In Individuals With Azoospermia Or Severe Oligospermia, Zeynep Ocak, Uğur Üyetürk, Muhammet Murat Di̇nçer
Clinical And Prognostic Importance Of Chromosomal Abnormalities, Y Chromosome Microdeletions, And Cftr Gene Mutations In Individuals With Azoospermia Or Severe Oligospermia, Zeynep Ocak, Uğur Üyetürk, Muhammet Murat Di̇nçer
Turkish Journal of Medical Sciences
To illustrate the importance of genetic screening in the assessment of fertility and the correct diagnosis in patients with azoospermia or severe oligospermia. Materials and methods: This study examined 500 patients with reproductive failure, having fewer than 5 million sperm/mL detected in at least 2 consecutive spermiograms, who presented at a medical genetics polyclinic between 2008 and 2012. Metaphase preparations obtained from cell cultures were stained by trypsin-Giemsa banding. After DNA isolation, Y chromosome loci, including AZFa (SY84, SY86), AZFb (SY127, SY134), AZFc (SY254 SY255), and AZFd, were amplified by polymerase chain reaction using specific primers. Thirty-five patients with congenital …
Effects Of The Medial Or Basolateral Amygdala Upon Social Anxiety And Social Recognition In Mice, Yu Wang, Shanshan Zhao, Xu Liu, Qunying Fu
Effects Of The Medial Or Basolateral Amygdala Upon Social Anxiety And Social Recognition In Mice, Yu Wang, Shanshan Zhao, Xu Liu, Qunying Fu
Turkish Journal of Medical Sciences
Though social anxiety and social recognition have been studied extensively, the roles of the medial or basolateral amygdala in the control of social anxiety and social recognition remain to be determined. This study investigated the effects of excitotoxic bilateral medial or basolateral amygdala lesions upon social anxiety and social recognition in mice. Materials and methods: Animals at 9 weeks of age were given bilateral medial or basolateral amygdala lesions via infusion of N-methyl-D-aspartate and then were used for behavioral tests: anxiety-related tests (including open-field test, light-dark test, and elevated-plus maze test), social behavior test in a novel environment, social recognition …
Neutrophil-Lymphocyte Ratio As A Predictive Factor For Tumor Staging In Colorectal Cancer, Gülay Özgehan, Şahi̇n Kahramanca, İsmai̇l Oskay Kaya, Köksal Bi̇lgen, Hasan Bostanci, Hakan Güzel, Tevfi̇k Hadi̇ Küçükpinar, Hülagü Kargici
Neutrophil-Lymphocyte Ratio As A Predictive Factor For Tumor Staging In Colorectal Cancer, Gülay Özgehan, Şahi̇n Kahramanca, İsmai̇l Oskay Kaya, Köksal Bi̇lgen, Hasan Bostanci, Hakan Güzel, Tevfi̇k Hadi̇ Küçükpinar, Hülagü Kargici
Turkish Journal of Medical Sciences
In the preoperative period, simple methods to identify the tumor stage of colorectal cancer patients are needed. In recent years, the neutrophil-lymphocyte ratio (NLR) has been used as a predictive parameter for systemic inflammatory response in many different clinical entities. This study aims to determine if the NLR predicts the tumor stage in colorectal cancer patients in the preoperative period. Materials and methods: A total of 206 patients diagnosed with colorectal cancer and admitted for surgical treatment over a 6-year period were identified from a retrospectively maintained database. NLR was calculated from preoperative full blood counts. NLRs were compared with …
Chronic Moderate Alcohol Consumption Induces Inos Expression In The Penis: An Immunohistochemical Study, Süheyla Gonca, Yusufhan Yazir, Semi̇l Selcen Göçmez, Eki̇m Nur Dalçik, Ti̇jen Utkan, Hakki Dalçik
Chronic Moderate Alcohol Consumption Induces Inos Expression In The Penis: An Immunohistochemical Study, Süheyla Gonca, Yusufhan Yazir, Semi̇l Selcen Göçmez, Eki̇m Nur Dalçik, Ti̇jen Utkan, Hakki Dalçik
Turkish Journal of Medical Sciences
To investigate the effect of moderate alcohol consumption on metabolic alterations, inducible nitric oxide synthase (iNOS), immunohistochemical distribution, and morphological damage to penile erectile tissue in rats. Materials and methods: Male Wistar albino rats were divided into 2 groups. Group 1 rats (control group, n = 8) received tap water ad libitum, and group 2 rats (n = 8) were fed with 20% ethanol. Increasing levels of alcohol were given to the rats over 12 weeks. Immunohistochemistry was then performed using the avidin-biotin-peroxidase technique on 5-um thickness tissue sections. Stained sections were examined by imaging microscope. Results: Alcohol consumption resulted …
Protective Effects Of Montelukast And Hypericum Perforatum Against Intestinal Ischemia-Reperfusion Injury In Hamsters, Tarik Ocak, Ari̇f Duran, Gülzade Özyalvaçli, Zeynep Ocak, Elçi̇n Hakan Terzi̇, Mehmet Tosun, Kemaletti̇n Erdem
Protective Effects Of Montelukast And Hypericum Perforatum Against Intestinal Ischemia-Reperfusion Injury In Hamsters, Tarik Ocak, Ari̇f Duran, Gülzade Özyalvaçli, Zeynep Ocak, Elçi̇n Hakan Terzi̇, Mehmet Tosun, Kemaletti̇n Erdem
Turkish Journal of Medical Sciences
To evaluate the effects of montelukast and Hypericum perforatum against ischemia/reperfusion (I/R)-induced intestinal damage. Materials and methods: Twenty-eight hamsters were divided into 4 groups following midline abdominal laparotomy: control group (n = 7), I/R group (n = 7), montelukast and I/R (MIR) group (n = 7), and Hypericum perforatum and I/R (HPIR) group (n = 7). After 60 min of ischemia through obstruction of the superior mesenteric artery, 24 h of reperfusion was maintained. Ten minutes prior to the reperfusion period, the MIR group received 7 mg/kg of intraperitoneal montelukast and the HPIR group received 7 mg/kg of intraperitoneal Hypericum …
Gleason Score At The Margin Can Predict Biochemical Recurrence After Radical Prostatectomy, In Addition To Preoperative Psa And Surgical Margin Status, Sidika Şeyma Özkanli, Itir Ebru Zemheri̇, Asif Yildirim, Hati̇ce Deni̇z Gür, Mevlana Derya Balbay, Serkan Şenol, Ahmet Oğuz Özkanli, Erdal Alkan, Tülay Zengi̇nki̇net, Abdullah Aydin, Turhan Çaşkurlu
Gleason Score At The Margin Can Predict Biochemical Recurrence After Radical Prostatectomy, In Addition To Preoperative Psa And Surgical Margin Status, Sidika Şeyma Özkanli, Itir Ebru Zemheri̇, Asif Yildirim, Hati̇ce Deni̇z Gür, Mevlana Derya Balbay, Serkan Şenol, Ahmet Oğuz Özkanli, Erdal Alkan, Tülay Zengi̇nki̇net, Abdullah Aydin, Turhan Çaşkurlu
Turkish Journal of Medical Sciences
To evaluate the relation between biochemical recurrence (BCR) of prostate cancer and the extent of positive surgical margins (PSMs), Gleason score (GS) of the tumor at the margins, and preoperative prostate-specific antigen (PSA) levels. Materials and methods: A total of 94 patients who underwent radical prostatectomy were recruited for this study and received postoperative follow-up care for 2 years. All specimens were evaluated for surgical margin status, PSM length, GS at positive margin, size of tumor, multifocality, invasion of seminal vesicle, lymphovascular invasion, and perineural invasion. PSM was defined as a prostate tumor. Results: Out of 94 patients, 34 patients …
Effects Of Whole-Body Vibration On Plasma Sclerostin Level In Healthy Women, Muharrem Çi̇dem, Yunus Karakoç, Hakan Ekmekçi̇, Suat Hayri̇ Küçük, Murat Uludağ, Kerem Gün, Şafak Sahi̇r Karamehmetoğlu, İlhan Karacan
Effects Of Whole-Body Vibration On Plasma Sclerostin Level In Healthy Women, Muharrem Çi̇dem, Yunus Karakoç, Hakan Ekmekçi̇, Suat Hayri̇ Küçük, Murat Uludağ, Kerem Gün, Şafak Sahi̇r Karamehmetoğlu, İlhan Karacan
Turkish Journal of Medical Sciences
To determine whether plasma sclerostin levels are affected by applying whole-body vibration treatments. Materials and methods: Following a pilot study, the present prospective, randomized, controlled single-blind study was performed on 16 healthy volunteer women (ages 20 to 40 years). Subjects were randomly divided into 2 groups, and whole-body vibration was applied to the treatment group but not to the controls. The plasma sclerostin levels were measured before the treatment and at the 10th minute after whole-body vibration on the 1st, 2nd, and 5th days of application. Results: The plasma sclerostin level measured at 10 min after the whole-body vibration treatment …
Relation Of Age And Sex With Carotid Intima Media Thickness In Healthy Children, Ali̇ Koçyi̇ği̇t, Mustafa Doğan, İsmai̇l Yilmaz, Murat Çağlar, Celi̇le Hati̇poğlu, Fi̇gen Koçyi̇ği̇t, Duygu Herek, Nevzat Karabulut
Relation Of Age And Sex With Carotid Intima Media Thickness In Healthy Children, Ali̇ Koçyi̇ği̇t, Mustafa Doğan, İsmai̇l Yilmaz, Murat Çağlar, Celi̇le Hati̇poğlu, Fi̇gen Koçyi̇ği̇t, Duygu Herek, Nevzat Karabulut
Turkish Journal of Medical Sciences
To investigate the age- and sex-associated carotid intima media thickness (cIMT) changes in healthy children to determine the age- and sex-specific normal range of values for childhood. Materials and methods: This study examined 91 healthy school-age children aged 7-15 years prospectively. Standardized sonographic cIMT measurements and analyses were performed. Body mass index and blood pressure were obtained, and atherosclerotic risk factors were investigated. Age-and sex-specific cIMT measurements for different age groups were calculated and the relation with sex was investigated. Results: Regarding the total study group, mean cIMT measurements for age groups 7-9, 10-12, and 13-15 years were 4.1 ± …
Is Trichoscan A New Diagnostic Method For Diffuse Hair Loss?, Hati̇ce Uce Özkol, Ömer Çalka, Necmetti̇n Akdeni̇z
Is Trichoscan A New Diagnostic Method For Diffuse Hair Loss?, Hati̇ce Uce Özkol, Ömer Çalka, Necmetti̇n Akdeni̇z
Turkish Journal of Medical Sciences
In this study, we investigated the sensitivity of TrichoScan, a computer-based phototrichogram, in the evaluation of diffuse hair loss in women and the relationship between iron deficiency anemia and hair loss. Materials and methods: We recruited 100 female patients with diffuse hair loss. In all of the patients, a 1-cm2 area of hair located in a temporoparietal region was shortened to 0.5 mm. The shaved scalp regions were stained with black dye. The subject then waited for 12 min. Subsequently, pictures of these regions were taken with a videodermoscope and analyzed with the TrichoScan software program. Results: The ferritin levels …
Neuropharmacological Effects Of Methanolic Extracts Of Rubus Fruticosus L., Muhammad Riaz, Muhammad Zia-Ul-Haq, Najm Ur-Rahman, Mansoor Ahmad
Neuropharmacological Effects Of Methanolic Extracts Of Rubus Fruticosus L., Muhammad Riaz, Muhammad Zia-Ul-Haq, Najm Ur-Rahman, Mansoor Ahmad
Turkish Journal of Medical Sciences
To investigate methanol extracts of various parts of Rubus fruticosus L. (Rosaceae) for various neuropharmacological activities, such as anxiolytic, muscle relaxant, antidepressant, and sedative activities. Materials and methods: The extracts were administered to albino mice orally at doses of 100, 300, and 500 mg/kg. The antidepressant activity was determined by using the forced swimming test, while line crossing in a special box was used for assessment of locomotor activity. Results: All extracts were found to be anxiolytic in nature, while no muscle relaxing activity or sedative effect was observed. The order of central nervous system (CNS) depressant effect for various …
Detection Of Kinase Amplifications In Gastric Adenocarcinomas, Muhsi̇n Özdemi̇r, Murat Öznur, Evri̇m Çi̇ftçi̇, Beyhan Durak Aras, Hüseyi̇n Aslan, Hande Saygili, Kevser Setenay Öner, Serdar Mustafa Erkasap, Ayşegül Özakyol, Özgül Paşaoğlu, Oğuz Çi̇li̇ngi̇r, Sevi̇lhan Artan
Detection Of Kinase Amplifications In Gastric Adenocarcinomas, Muhsi̇n Özdemi̇r, Murat Öznur, Evri̇m Çi̇ftçi̇, Beyhan Durak Aras, Hüseyi̇n Aslan, Hande Saygili, Kevser Setenay Öner, Serdar Mustafa Erkasap, Ayşegül Özakyol, Özgül Paşaoğlu, Oğuz Çi̇li̇ngi̇r, Sevi̇lhan Artan
Turkish Journal of Medical Sciences
To determine the incidences of copy number aberrations of receptor kinases and their relations in Turkish patients with gastric adenocarcinoma. Materials and methods: The prevalence of genomic copy number aberrations of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2)/topoisomerase IIa (TOP2A), centrosome-associated kinase aurora A (AURK A), centrosome-associated kinase aurora B (AURK B), and mesenchymal-epithelial transition factor (MET) genes and polysomies of related chromosomes were analyzed by fluorescent in situ hybridization (FISH) in tumor samples from 35 patients with gastric cancer. Results: There were 28.6%, 65.7%, 20.0%, 17.1%, 60.0%, and 45.7% cases considered FISH-positive for EGFR, …
Evaluation Of Patients With Zygomycosis, Onur Kaya, Sema Alp Çavuş, Özge Turhan, Meltem Işikgöz Taşbakan, Hüsnü Pullukçu, Mustafa Bülent Ertuğrul, Şebnem Şenol, Çi̇ğdem Banu Çeti̇n, Beti̇l Özhak Baysan, Selda Sayin Kutlu, Di̇lek Yeşi̇m Meti̇n, Meltem Avci, Gülşen Mermut, Vi̇ldan Avkan Oğuz, Nur Yapar
Evaluation Of Patients With Zygomycosis, Onur Kaya, Sema Alp Çavuş, Özge Turhan, Meltem Işikgöz Taşbakan, Hüsnü Pullukçu, Mustafa Bülent Ertuğrul, Şebnem Şenol, Çi̇ğdem Banu Çeti̇n, Beti̇l Özhak Baysan, Selda Sayin Kutlu, Di̇lek Yeşi̇m Meti̇n, Meltem Avci, Gülşen Mermut, Vi̇ldan Avkan Oğuz, Nur Yapar
Turkish Journal of Medical Sciences
Zygomycosis is a severe angioinvasive infection caused by Zygomycetes. We retrospectively investigated 16 cases of zygomycosis. Materials and methods: The data of patients, who had been followed between 2004 and 2010 in 8 tertiary-care teaching hospitals, were reviewed. Demographic characteristics, underlying diseases, and clinical signs and symptoms of the patients, as well as diagnostic methods, data obtained by radiological imaging methods, and the therapies, were recorded. Therapeutic approaches, antifungal agents and duration of use, and the characteristics of the cases were identified. Results: The study included 11 female and 5 male subjects. The most common symptoms and clinical signs were …
An Anatomical Study On The Facial Nerve Trunk In Fetus Cadavers, Ahmet Kalaycioğlu, Gülay Yegi̇noğlu, Canan Ertemoğlu Öksüz, Özlem Uzun, Şahi̇ Nur Kalkişim
An Anatomical Study On The Facial Nerve Trunk In Fetus Cadavers, Ahmet Kalaycioğlu, Gülay Yegi̇noğlu, Canan Ertemoğlu Öksüz, Özlem Uzun, Şahi̇ Nur Kalkişim
Turkish Journal of Medical Sciences
Facial nerve paralysis is the most worrying parotid surgery complication. Little attention has been paid to the facial nerve trunk, especially in children. Pathological variations, tumors, and anatomic variations of the facial nerve may cause parotid and facial nerve surgery difficulties. This study describes the facial nerve trunk. Materials and methods: We measured the facial nerve trunk from 8 female and 8 male fetus cadavers aged 21.0 to 35.5 gestational weeks. The locations and positions of the trunks were described. The length of the facial nerve trunk (K) was measured and bifurcation and trifurcation of the trunk was examined. Values …
Resistin Predicts Ischemia In Myocardial Perfusion Scintigraphy, Mustafa Yildirim, Meli̇h Engi̇n Erkan, Muhammet Aşik, Taner Uçgun, Ayşe Yilmaz, Huri̇ Ti̇lla İlçe, Yusuf Aslantaş, Ramazan Memi̇şoğullari, Serkan Bulur, Ahmet Semi̇h Doğan
Resistin Predicts Ischemia In Myocardial Perfusion Scintigraphy, Mustafa Yildirim, Meli̇h Engi̇n Erkan, Muhammet Aşik, Taner Uçgun, Ayşe Yilmaz, Huri̇ Ti̇lla İlçe, Yusuf Aslantaş, Ramazan Memi̇şoğullari, Serkan Bulur, Ahmet Semi̇h Doğan
Turkish Journal of Medical Sciences
Resistin plays a role in the pathogenesis of coronary artery disease and is related to mortality and morbidity through a number of mechanisms. We hypothesize that plasma resistin levels are increased in the presence of ischemia, as measured by GATED single-photon emission computed tomography myocardial perfusion scintigraphy (SPECT MPS), in comparison with nonischemic subjects. Materials and methods: Fasting intravenous blood samples of patients were drawn before a stress test. An ELISA kit was used for the assays. All patients underwent a technetium 99m-sestamibi GATED SPECT MPS study with a 1-day stress-rest protocol. Images were analyzed visually and patients were assessed …
Prevalence Of Blabstractp And Blavim Gene Carriage In Metallo-\Beta-Lactamase-Producing Burn Isolates Of Pseudomonas Aeruginosa In Tehran, Fatemeh Salimi, Fereshteh Eftekhar
Prevalence Of Blabstractp And Blavim Gene Carriage In Metallo-\Beta-Lactamase-Producing Burn Isolates Of Pseudomonas Aeruginosa In Tehran, Fatemeh Salimi, Fereshteh Eftekhar
Turkish Journal of Medical Sciences
To study the prevalence of bla_{VIM} and bla_{IMP} genes in metallo-\beta-lactamase (MBL)-producing burn isolates of Pseudomonas aeruginosa in relation with AmpC and extended-spectrum \beta-lactamase (ESBL) production. Materials and methods: Thirty-two carbapenem-resistant MBL-producing P. aeruginosa burn isolates from Shahid Motahari Burn Hospital in Tehran were employed. Antibiotic susceptibility was determined to 13 antibiotics including imipenem and meropenem by disk diffusion. AmpC and ESBL production was detected by the AmpC disk test and combined disk diffusion assay, respectively. bla_{IMP} and bla_{VIM} gene carriage was shown by polymerase chain reaction and type-specific primers. Results: AmpC production was observed in 81% and ESBL production …
What Is The Effect Of Radioiodine Therapy On Helicobacter Pylori Infection?, Celi̇l Alper Usluoğullari, Eda Demi̇r Önal, Eli̇f Özdemi̇r, Sedat Caner, Osman Ersoy, Reyhan Ersoy, Beki̇r Çakir
What Is The Effect Of Radioiodine Therapy On Helicobacter Pylori Infection?, Celi̇l Alper Usluoğullari, Eda Demi̇r Önal, Eli̇f Özdemi̇r, Sedat Caner, Osman Ersoy, Reyhan Ersoy, Beki̇r Çakir
Turkish Journal of Medical Sciences
Helicobacter pylori is an important human pathogen associated with gastric and duodenal ulcers, gastric mucosa-associated lymphoid tissue lymphoma, and adenocarcinoma. Radioiodine (RAI) treatment plays an important role in the management of differentiated thyroid cancer and primary hyperthyroidism. It is known that during RAI treatment, a considerable amount is absorbed by the stomach as well. In this study we aimed to reveal any therapeutic impact of RAI on H. pylori infections. Materials and methods: Eighty-seven patients who were hospitalized for RAI treatment were consecutively included in this study. Of those, 76 patients had differentiated thyroid cancer and 11 had primary hyperthyroidism. …
Pulsatile Ocular Blood Flow Changes After Panretinal Photocoagulation Treatment In Patients With Proliferative Diabetic Retinopathy, Adem Türk, Cenap Mahmut Esenülkü, Nuretti̇n Akyol, Mehmet Kola, Hi̇dayet Erdöl, Hali̇l İbrahi̇m İmamoğlu
Pulsatile Ocular Blood Flow Changes After Panretinal Photocoagulation Treatment In Patients With Proliferative Diabetic Retinopathy, Adem Türk, Cenap Mahmut Esenülkü, Nuretti̇n Akyol, Mehmet Kola, Hi̇dayet Erdöl, Hali̇l İbrahi̇m İmamoğlu
Turkish Journal of Medical Sciences
To prospectively assess the effects of panretinal photocoagulation (PRP) treatment on pulsatile ocular blood flow (POBF) in patients with proliferative diabetic retinopathy (PDRP). Materials and methods: The study included 40 eyes with PDRP in 27 patients. The PRP treatments were completed in 3 sessions with 3-week intervals. The intraocular pressure (IOP), pulse amplitude (PA), pulse volume (PV), and POBF changes that arose during the sessions were recorded using a blood flow analyzer. Results: The average age of the patients was 57.37 ± 11.14 years. The pre-PRP basal IOP, PA, PV, and POBF values were 20.44 ± 4.13 mmHg, 4.23 ± …
An Unusual Case Of Sclerosing Angiomatoid Nodular Transformation: Radiological And Histopathological Analyses, Meli̇ke Ruşen Meti̇n, Şehnaz Evri̇mler, Nurdan Çay, Hüseyi̇n Çeti̇n
An Unusual Case Of Sclerosing Angiomatoid Nodular Transformation: Radiological And Histopathological Analyses, Meli̇ke Ruşen Meti̇n, Şehnaz Evri̇mler, Nurdan Çay, Hüseyi̇n Çeti̇n
Turkish Journal of Medical Sciences
Sclerosing angiomatoid nodular transformation (SANT) is a rare benign primary vascular lesion of the spleen. Its etiology is still debated. Radiological characteristics are less known, although there are some reports regarding histopathological features of SANT. A 21-year-old male patient was admitted to our hospital with fatigue, weight loss, and abdominal pain for 4 months. Physical examination, complete blood count, and biochemical parameters were unremarkable. Dynamic contrast-enhanced computed tomography (CT) of the abdomen was performed. A heterogeneous well-defined hyperdense nodular lesion 3 cm in diameter was detected during the arterial phase. The detected lesion was seen as isodense with the spleen …
Liver Enzymes, Mean Platelet Volume, And Red Cell Distribution Width In Gestational Diabetes, Serpi̇l Erdoğan, Özhan Özdemi̇r, Halef Okan Doğan, Sevi̇lay Sezer, Cemal Reşat Atalay, Fatma Meri̇ç Yilmaz, Yüksel Koca
Liver Enzymes, Mean Platelet Volume, And Red Cell Distribution Width In Gestational Diabetes, Serpi̇l Erdoğan, Özhan Özdemi̇r, Halef Okan Doğan, Sevi̇lay Sezer, Cemal Reşat Atalay, Fatma Meri̇ç Yilmaz, Yüksel Koca
Turkish Journal of Medical Sciences
To investigate the value of measuring liver enzymes, red cell distribution width (RDW), and mean platelet volume (MPV) in predicting the development of gestational diabetes mellitus (GDM). Materials and methods: The medical records of all pregnant women followed by the obstetrics clinic between January 2010 and November 2012 were systematically evaluated, and patients with a diagnosis of GDM were identified. A total of 68 patients with GDM and 61 healthy controls were included in the study. Results of relevant laboratory parameters were recorded. Results: Out of all the parameters evaluated, mean values for platelet distribution width (PDW) and mean activities …
Detection Of Caga And Vaca Genotypes Of Helicobacter Pylori Isolates From A University Hospital In Ankara Region, Turkey, Ceren Erdoğdu, Zeynep Saribaş, Yakut Akyön Yilmaz
Detection Of Caga And Vaca Genotypes Of Helicobacter Pylori Isolates From A University Hospital In Ankara Region, Turkey, Ceren Erdoğdu, Zeynep Saribaş, Yakut Akyön Yilmaz
Turkish Journal of Medical Sciences
The cagA and vacA profiles and their association with clinical findings show a distinct geographical distribution. In the present study, we aimed to determine the cagA status and vacA allelic subtypes in strains isolated from a university hospital in Ankara and to evaluate their associations with histopathological and endoscopic findings. Materials and methods: A total of 120 H. pylori strains from stock cultures positive for the ureA gene were randomly included in the present study. Of these strains, cagA and vacA allelic subtypes (s1a, s1b, s2, m1, m2) were examined by polymerase chain reaction. Results: Of the 120 strains, 64 …
Diastolic Function Of The Right Ventricle Is Impaired In Experimental Type 2 Diabetic Rat Models, Ya Miao, Wei Zhang, Yuan Zhong, Ming Zhong, Xiao Ma
Diastolic Function Of The Right Ventricle Is Impaired In Experimental Type 2 Diabetic Rat Models, Ya Miao, Wei Zhang, Yuan Zhong, Ming Zhong, Xiao Ma
Turkish Journal of Medical Sciences
To evaluate diastolic function alterations of the right ventricle (RV) by echocardiography in type 2 diabetic rat models. Materials and methods: Male Wistar rats were divided into 2 groups: a control group (n = 8) and a diabetic group (n = 16, with 11 remaining at the end of the experiment), which was fed a high-fat and high-calorie diet and injected with streptozotocin (STZ). RV diastolic functional alteration of rat models was studied by the tricuspid flow Doppler (Ep, Ap, and Ep/Ap) and tissue Doppler imaging (TDI) (Em, Am, and Em/Am) of the lateral tricuspid annulus. RV structural alteration of …
Vitamin C As An Antioxidant: Evaluation Of Its Role On Pulmonary Contusion Experimental Model, Rana Sirmali, Zeynep Gi̇ni̇ş, Mehmet Sirmali, Okan Solak, Bengü Şeli̇man, Yetki̇n Ağaçkiran, Namik Deli̇baş
Vitamin C As An Antioxidant: Evaluation Of Its Role On Pulmonary Contusion Experimental Model, Rana Sirmali, Zeynep Gi̇ni̇ş, Mehmet Sirmali, Okan Solak, Bengü Şeli̇man, Yetki̇n Ağaçkiran, Namik Deli̇baş
Turkish Journal of Medical Sciences
To analyze the protective activity of vitamin C on the lungs by assessing biochemical and histopathological analysis after performing an experimental isolated lung contusion model. Materials and methods: Fifty-four male Sprague-Dawley male rats were used. The rats were randomly separated into 4 groups. Vitamin C (200 mg/kg) was injected intraperitoneally 30 min after trauma. Blood samples were obtained for myeloperoxidase (MPO), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT) activities and malondialdehyde (MDA) levels. Blood gas analysis and bronchoalveolar lavage was performed. The lung tissue was also extracted for histopathological examination. Results: The lung contusion enhanced MDA, SOD, CAT, …
Evaluation Of 4 Methods For The Serological Diagnosis Of EpsteinBarr Virus Infection Using An Immunofluorescence Assay As The Reference Method, Mücahi̇de Esra Koçoğlu, Teki̇n Taş, Firat Zafer Mengeloğlu, Şeyda Özsoy, Özlem Bucak
Evaluation Of 4 Methods For The Serological Diagnosis Of EpsteinBarr Virus Infection Using An Immunofluorescence Assay As The Reference Method, Mücahi̇de Esra Koçoğlu, Teki̇n Taş, Firat Zafer Mengeloğlu, Şeyda Özsoy, Özlem Bucak
Turkish Journal of Medical Sciences
Tests specific for VCA IgM, VCA IgG, and EBNA IgG are used to diagnose Epstein-Barr virus (EBV) infections and interpret disease status. The immunofluorescence assay (IFA) is accepted as the gold standard test. The purpose of this study was to evaluate the performance of 4 methods in comparison with IFA. Materials and methods: In total, 101 serum samples were obtained from clinically suspected cases of EBV infection between May 2010 and May 2012 and evaluated by IFA. All serum samples were analyzed by an immunoblot assay, enzyme-linked fluorescent assay (ELFA), enzyme immunoassay (EIA), and immunochromatographic assay (ICA). Results: ELFA and …
Cell Apoptosis And Proliferation In Rat Brains After Intracerebral Hemorrhage: Role Of Wnt/\Beta-Catenin Signaling Pathway, Ling Zhou, Li Deng, Neng Bin Chang, Ling Dou, Chao Xian Yang
Cell Apoptosis And Proliferation In Rat Brains After Intracerebral Hemorrhage: Role Of Wnt/\Beta-Catenin Signaling Pathway, Ling Zhou, Li Deng, Neng Bin Chang, Ling Dou, Chao Xian Yang
Turkish Journal of Medical Sciences
To investigate the role of Wnt/\beta-catenin signaling pathway in cell apoptosis and proliferation in intracerebral hemorrhage (ICH) in rats. Materials and methods: The ICH rats were established by stereotaxic infusion of 50 µL autologous arterial blood into the right striatum. Pathological characteristics of brain tissue was assessed by hematoxylin and eosin and TUNEL staining, and the expressions of proliferating cell nuclear antigen (PCNA) and Wnt3a/\beta-catenin/cyclin D1 were investigated by immunohistochemistry or reverse-transcription polymerase chain reaction. Results: The number of apoptotic cells and PCNA-positive cells kept increasing from the day following the ICH induction and reached a peak on the 3rd …
Investigation Of Serum Macrophage Migration Inhibitor Factor And Monocyte Chemotactic Protein-1 Levels In Irritable Bowel Syndrome, Feti̇ Tülübaş, Mustafa Oran, Rafet Mete, Fi̇li̇z Turan, Ahsen Yilmaz, Zeynep Deni̇z Yildiz, Ahmet Gürel
Investigation Of Serum Macrophage Migration Inhibitor Factor And Monocyte Chemotactic Protein-1 Levels In Irritable Bowel Syndrome, Feti̇ Tülübaş, Mustafa Oran, Rafet Mete, Fi̇li̇z Turan, Ahsen Yilmaz, Zeynep Deni̇z Yildiz, Ahmet Gürel
Turkish Journal of Medical Sciences
Irritable bowel syndrome (IBS), a functional disorder of the bowel, has been thought to result from immune activation. The aim of this study was to evaluate macrophage migration inhibitory factor (MMIF) and monocyte chemotactic protein-1 (MCP-1) levels in IBS patients. Materials and methods: We enrolled 30 IBS patients and 30 healthy controls. The MMIF and MCP-1 levels of all patients and controls were detected using commercial enzyme-linked immunosorbent assay kits. Results: Serum MMIF and MCP-1 levels were markedly higher in IBS patients than in controls. White blood cell, neutrophil, lymphocyte, monocyte, eosinophil, and basophil counts did not differ significantly between …
Association Analyses Of Oxidative Stress, Aerobic Capacity, Daily Physical Activity, And Body Composition Parameters In Patients With Mild To Moderate Copd, Abdurrahman Genç, Kağan Üçok, Ümi̇t Şener, Tülay Koyuncu, Olcay Akar, Sefa Çeli̇k, Mehmet Ünlü
Association Analyses Of Oxidative Stress, Aerobic Capacity, Daily Physical Activity, And Body Composition Parameters In Patients With Mild To Moderate Copd, Abdurrahman Genç, Kağan Üçok, Ümi̇t Şener, Tülay Koyuncu, Olcay Akar, Sefa Çeli̇k, Mehmet Ünlü
Turkish Journal of Medical Sciences
To investigate total oxidant and antioxidant status, maximal aerobic capacity, daily physical activity, pulmonary functions, and body composition changes, as well as the associations among these parameters, in patients with mild to moderate chronic obstructive pulmonary disease (COPD) versus healthy controls. Materials and methods: The study included 30 male patients newly diagnosed with COPD and 30 body mass index-matched, nonsmoker male controls. Maximal aerobic capacity, daily physical activity, total oxidant and antioxidant status, pulmonary function tests, body composition, and anthropometric parameters were measured. Results: Maximal aerobic capacity and total antioxidant values were lower in patients with COPD compared to the …
Effects Of Oral Hormone Replacement Therapy On Mean Platelet Volume In Postmenopausal Women, İkbal Kaygusuz, Serap Aynur Si̇mavli, Ayla Eser, İlknur İnegöl Gümüş, Selcen Yüksel, Zehra Candan İltemi̇r Duvan, Hasan Kafali
Effects Of Oral Hormone Replacement Therapy On Mean Platelet Volume In Postmenopausal Women, İkbal Kaygusuz, Serap Aynur Si̇mavli, Ayla Eser, İlknur İnegöl Gümüş, Selcen Yüksel, Zehra Candan İltemi̇r Duvan, Hasan Kafali
Turkish Journal of Medical Sciences
To examine the effects of hormone replacement therapy (HRT) on mean platelet volume (MPV), lipid profile, and C-reactive protein (CRP) levels in postmenopausal women who have a high risk and incidence of cardiovascular disease. Materials and methods: This study was performed retrospectively. Twenty-seven healthy postmenopausal women received 1 mg estradiol and 2 mg drospirenone orally for 6 months. Twenty-eight healthy postmenopausal women not taking any HRT were admitted to the study as the control population. Results: Time effect (independent from group effect) was statistically significant for the MPV variable (P = 0.025), but there was no significant change in MPV …
Endobronchial Ultrasound-Guided Transbronchial Needle Biopsy For The Diagnosis Of Mediastinal Lymphadenopathy In Patients With Extrathoracic Malignancies, Ayşegül Şentürk, Hati̇ce Kiliç, Habi̇be Hezer, Funda Karaduman Yalçin, Hati̇ce Canan Hasanoğlu
Endobronchial Ultrasound-Guided Transbronchial Needle Biopsy For The Diagnosis Of Mediastinal Lymphadenopathy In Patients With Extrathoracic Malignancies, Ayşegül Şentürk, Hati̇ce Kiliç, Habi̇be Hezer, Funda Karaduman Yalçin, Hati̇ce Canan Hasanoğlu
Turkish Journal of Medical Sciences
Mediastinal lymphadenopathy is common in extrathoracic malignancies and should not always be considered a metastatic lesion. The purpose of this study is to determine the diagnostic value of endobronchial ultrasound-guided transbronchial needle biopsy (EBUS-TBNA) in patients with extrathoracic malignancies. Materials and methods: This study included 54 consecutive patients with extrathoracic malignancies who had suspected mediastinal metastases and had undergone EBUS-TBNA for diagnosis. Results: Using EBUS-TBNA, 27 of 54 patients (50%) were diagnosed with mediastinal metastases. Among patients with mediastinal metastases, 2 (3.7%) had a sarcoid-like reaction, 5 (9.3%) had tuberculosis, and 17 (31.5%) had reactive lymph nodes. In 3 cases …
Effect Of Nodule Size On The Reliability Of Fine-Needle Aspiration Biopsy In Thyroid Nodules, Ali̇ Erkan Uçar, Seyyi̇t Muhsi̇n Sarikaya, Ömer Parlak, Abdussamed Yalçin
Effect Of Nodule Size On The Reliability Of Fine-Needle Aspiration Biopsy In Thyroid Nodules, Ali̇ Erkan Uçar, Seyyi̇t Muhsi̇n Sarikaya, Ömer Parlak, Abdussamed Yalçin
Turkish Journal of Medical Sciences
To investigate the reliability of fine-needle aspiration biopsy (FNAB) in thyroid nodules and benign/malignant discrimination, particularly in large nodules. Materials and methods: A retrospective analysis of 1466 nodules in 402 patients with thyroid nodules who underwent thyroid surgery was made. The pathologic results of the thyroid nodules from preoperative FNAB and postoperative surgical pathology results were compared. Results: FNAB was found to be in accordance with the postoperative pathologic results. A concordance between the FNAB and postoperative pathologic results, particularly in nodules less than 3 cm in size, was detected. However, a similar finding was not detected in nodules larger …