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Association Of Certain Biochemical Parameters Related To Bone Cycle With Genotype In Mps Iii-B Patients, Seda Gökkurt, İrem Peker Eyüboğlu, Banu Nur Güzel, Ercan Mihçi, Ayşe Özer, Mustafa Akki̇pri̇k Feb 2025

Association Of Certain Biochemical Parameters Related To Bone Cycle With Genotype In Mps Iii-B Patients, Seda Gökkurt, İrem Peker Eyüboğlu, Banu Nur Güzel, Ercan Mihçi, Ayşe Özer, Mustafa Akki̇pri̇k

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to investigate the genotype-phenotype correlation in Sanfilippo type B patients in terms of bone formation/resorption parameters, and to determine the release/inhibition of biomarkers accompanying osteoporosis.Materials and Methods: Plasma levels of Osteoprotegerin, Matrix metalloproteinases (MMP2, MMP9), TIMP-1, TIMP-2, BALP, Cathepsin K, and TRACP-5b were examined by ELISA method in MPS IIIB patients. At the same time, mutations in the NAGLU gene causing this disease were detected by whole exome sequencing, and their correlation with biochemical parameters was investigated.Results: Based on the enzyme analysis results, MMP-9, TIMP1, TIMP-2, and MMP-2 were significantly high, while Cathepsin-K …


Ascorbic Acid Exhibits More Of A Protective Effect Than Estradiol Against Nephrotoxicity Induced By Malathion In Rats: A Histopathological And Molecular Docking Study, Mohammad Alhilal, Mahmoud Salem, Ahmed Albakoush, Suzan Alhilal, Basant Farag, Sobhi M. Gomha Feb 2025

Ascorbic Acid Exhibits More Of A Protective Effect Than Estradiol Against Nephrotoxicity Induced By Malathion In Rats: A Histopathological And Molecular Docking Study, Mohammad Alhilal, Mahmoud Salem, Ahmed Albakoush, Suzan Alhilal, Basant Farag, Sobhi M. Gomha

Turkish Journal of Medical Sciences

Background/Aim: Despite the known harmful effects associated with malathion toxicity in various organs, it continues to be widely used for plant protection and insect control. This study is the first to compare the protective effects of estradiol and ascorbic acid against malathion-induced nephrotoxicity through histopathological assessment and molecular docking analyses.

Materials and Methods: This study was conducted using 20 female albino rats that were distributed into sham, malathion, malathion + estradiol, and malathion + ascorbic acid groups. Nephrotoxicity was induced by daily treatment with malathion, and the effects of estradiol and ascorbic acid on nephrotoxicity were evaluated. After 4 weeks …


Could Eras Protocols Be Integrated Into The National Standards For Quality In Healthcare In Türkiye?, Mi̇ne Gürsaç Çeli̇k, Adem Az, Mehmet Çeti̇n, Nesli̇han Alkiş Feb 2025

Could Eras Protocols Be Integrated Into The National Standards For Quality In Healthcare In Türkiye?, Mi̇ne Gürsaç Çeli̇k, Adem Az, Mehmet Çeti̇n, Nesli̇han Alkiş

Turkish Journal of Medical Sciences

No abstract provided.


Erratum To “ Telemedicine In Pediatric Rheumatology: The Video Pediatric Gait, Arms, Legs, And Spine (V-Pgals) Examination” [Turkish Journal Of Medical Sciences 54 (5) 2024 963-969 ], Zeynep Balik, Seher Şener, Yağmur Bayindir, Müşerref Kasap Cüceoğlu, Emi̇l Ali̇yev, Özge Başaran, Yelda Bi̇lgi̇ner, Seza Özen, Ezgi̇ Deni̇z Batu Feb 2025

Erratum To “ Telemedicine In Pediatric Rheumatology: The Video Pediatric Gait, Arms, Legs, And Spine (V-Pgals) Examination” [Turkish Journal Of Medical Sciences 54 (5) 2024 963-969 ], Zeynep Balik, Seher Şener, Yağmur Bayindir, Müşerref Kasap Cüceoğlu, Emi̇l Ali̇yev, Özge Başaran, Yelda Bi̇lgi̇ner, Seza Özen, Ezgi̇ Deni̇z Batu

Turkish Journal of Medical Sciences

This erratum is written to correct an error in our previous publication. Supplement Figure 2 was published incorrectly as one page instead of six.
DOI of original article: https://doi.org/10.55730/1300-0144.5874


A Comparison Study Of Sensory Processing In Older Adults With And Without Dementia, Medi̇ne Nur Özata Değerli̇, Di̇dem Karaduman, Burcu Balam Doğu, Onur Altuntaş Feb 2025

A Comparison Study Of Sensory Processing In Older Adults With And Without Dementia, Medi̇ne Nur Özata Değerli̇, Di̇dem Karaduman, Burcu Balam Doğu, Onur Altuntaş

Turkish Journal of Medical Sciences

Background/aim: Sensory processing is affected by aging, and dementia may lead to changes in sensory processing. This study aimed to examine the differences in sensory processing and sensory modulation between older adults with and without dementia.Materials and methods: This study was designed as a comparative study of community-dwelling older adults aged 65 years and older with and without dementia. Participants and their caregivers were recruited at the occupational therapy clinic of a public hospital. They completed a sociodemographic information form and the Adolescent/Adult Sensory Profile to assess sensory processing and sensory modulation.Results: The study included 120 older adults (60 with …


Pharmacokinetics Of Liposomal Levamisole After Oral, Intramuscular, And Subcutaneousadministration In Sheep, Hasan Susar, İzzet Karahan Feb 2025

Pharmacokinetics Of Liposomal Levamisole After Oral, Intramuscular, And Subcutaneousadministration In Sheep, Hasan Susar, İzzet Karahan

Turkish Journal of Veterinary & Animal Sciences

This study aimed to determine the pharmacokinetics of free and liposomal levamisole in sheep following single oral (O),intramuscular (IM), and subcutaneous (SC) administrations at a dose of 7.5 mg/kg. The study developed a levamisole liposome andinvestigated relevant parameters: particle size, zeta potential, polydispersity index, encapsulation efficiency, pH, and morphology. TheBangham method, a thin-film hydration technique, was employed to prepare the liposomal levamisole. Blood samples were collectedby jugular venipuncture in heparinized tubes immediately before each free and liposomal levamisole treatment and at 2.5, 5, 10, 15,30, 60, 90, 120, 240, 360, and 480 min and 12, 16, and 24 h after …


Effects Of Ionophore And Yeast Addition To The Diet On Starch Digestion And Rumen Andblood Parameters In Sheep With Subacute Rumen Acidosis, Şevket Evci̇, Mehmet Aki̇f Karsli, Mehmet Demi̇rci̇, Gökhan Şen Jan 2025

Effects Of Ionophore And Yeast Addition To The Diet On Starch Digestion And Rumen Andblood Parameters In Sheep With Subacute Rumen Acidosis, Şevket Evci̇, Mehmet Aki̇f Karsli, Mehmet Demi̇rci̇, Gökhan Şen

Turkish Journal of Veterinary & Animal Sciences

This study aimed to investigate the prevention of acidosis in ruminants, which causes yield and financial losses, and toevaluate the effects of feed additives on starch digestion. Four male Bafra yearling lambs with cannulated rumens were used in a 60-daystudy. Each lamb underwent 10 days of adaptation to a ration and 5 days of sampling for four different rations including a control ration(CR), monensin ration (MR), Saccharomyces cerevisiae ration (SR), and a ration with the combination of monensin and Saccharomycescerevisiae (MSR). The experiment followed a 4 × 4 Latin-square design. Dry matter intake and digestion rates were recorded as 2404 …


Effects Of A Diet Supplemented With A Blend Of Protected Organic Acids And Essential Oilson Growth Performance And Cecal Microbiota Composition In Broilers, Mehmet Akan, Kadi̇r Serdar Di̇ker, Serdar Özlü, Murat Çelebi̇, Seyyi̇de Sariçam İnce, Barişhan Doğan, Okan Eli̇bol Jan 2025

Effects Of A Diet Supplemented With A Blend Of Protected Organic Acids And Essential Oilson Growth Performance And Cecal Microbiota Composition In Broilers, Mehmet Akan, Kadi̇r Serdar Di̇ker, Serdar Özlü, Murat Çelebi̇, Seyyi̇de Sariçam İnce, Barişhan Doğan, Okan Eli̇bol

Turkish Journal of Veterinary & Animal Sciences

Organic acids (OAs) and essential oils (EOs) have several positive effects on the gut microbiota of broilers. In this study, weaimed to determine the efficacy of a blend of protected OAs and EOs [P(OA+EO)] on the growth performance and cecal microbiota ofbroiler chickens. A total of 160 Ross 308 broiler chickens, including 80 male and 80 female birds, all 1 day old, were randomly distributedbetween the control group (basal diet) and the treatment group [basal diet + 300 g/t P(OA+EO)] according to an 8-pen arrangementwith 4 replicates of 20 birds. Body weight (BW), body weight gain (BWG), feed consumption (FC), …


Characterization Of The Biofilm-Forming Ability And Certain Virulence Characters Ofaeromonas Spp. Isolates From Rainbow Trout, Türker Çelebi̇, Ertan Emek Onuk, Esra Demi̇rbaş, Gökçen Di̇nç Jan 2025

Characterization Of The Biofilm-Forming Ability And Certain Virulence Characters Ofaeromonas Spp. Isolates From Rainbow Trout, Türker Çelebi̇, Ertan Emek Onuk, Esra Demi̇rbaş, Gökçen Di̇nç

Turkish Journal of Veterinary & Animal Sciences

Aeromonas spp., commonly found in the aquatic environment, cause infections in both fish and humans. Their pathogenicitydepends on various virulence factors and ability to form biofilm. The current study aimed to determine the biofilm-forming capabilitiesand certain virulence characteristics of 25 Aeromonas spp. isolates obtained from rainbow trout in Türkiye. The biofilm-forming abilitiesof isolates were investigated comparatively using Congo red agar (CRA), the tube method (TM), and tissue culture plates (TCPs).Potential virulence factors, including hemolytic activity, gelatinase production, serine protease activity, DNase activity, and motility,were evaluated using phenotypic tests. Additionally, the distribution of four known virulence genes, namely aerA, exu, fla, …


Cardiac Effects And Comorbidities Of Neurological Diseases, Bi̇lgi̇n Öztürk Dec 2024

Cardiac Effects And Comorbidities Of Neurological Diseases, Bi̇lgi̇n Öztürk

Turkish Journal of Medical Sciences

Neurological disorders encompass a complex and heterogeneous spectrum of diseases affecting the brain, spinal cord, and peripheral nervous system, each presenting unique challenges that extend well beyond primary neurological symptoms. These disorders profoundly impact cardiovascular health, prompting an intensified exploration into the intricate interconnections between the neurological and cardiovascular systems. This review synthesizes current insights and research on cardiovascular comorbidities associated with major neurological conditions, including stroke, epilepsy, Parkinson’s disease, multiple sclerosis (MS), and Alzheimer’s disease.The cardiovascular sequelae of these neurological disorders are multifactorial. For instance, strokes not only predispose individuals to arrhythmia and heart failure but also exacerbate pre-existing …


Hematological Diseases And Heart, Ferda Can Dec 2024

Hematological Diseases And Heart, Ferda Can

Turkish Journal of Medical Sciences

The heart, main part of the circulatory system, is one of the organs that frequently affected in hematological diseases. Cardiac problems may develop during the course and treatment of benign and malign hematological diseases. Determining cardiac approaches in hematological diseases with knowledge and experience about the development of cardiac involvements with pathophysiological conditions has an important role in the diagnosis and treatment process of patients. In this section, information about hematological diseases and the heart is included, and key points that will help in the diagnosis and treatment process are mentioned.


Thyroid And Cardiovascular Diseases, Si̇nem Başak Tan Öksüz, Mustafa Şahi̇n Dec 2024

Thyroid And Cardiovascular Diseases, Si̇nem Başak Tan Öksüz, Mustafa Şahi̇n

Turkish Journal of Medical Sciences

The thyroid gland is one of the major regulator organs of hemostasis in the human body, controlling the function of numerous systems. Thyroid hormones exert a modulating effect on particularly cardiovascular system, ensuring optimal functioning within the normal range. Triiodothyronine (T3), as an active form of thyroid hormones, is mainly responsible for this effect via both genomic and non-genomic mechanisms. It has been reported that overt thyroid disorders are associated with a number of cardiovascular diseases and cardiac mortality. While hyperthyroidism appears to be related to atrial fibrillation and heart failure, the most pronounced cardiovascular complication of hypothyroidism seems to …


Coexisting Growing Teratoma Syndrome And Gliomatosis Peritonei Following Ovarian Immature Teratoma: A Case Report And Literature Review, Osman Türkmen, Serra Akar İnan, Serap Akbay, Mohammad İbrahi̇m Hali̇lzade, İnci̇ Hali̇lzade, Özlem Moraloğlu Teki̇n Dec 2024

Coexisting Growing Teratoma Syndrome And Gliomatosis Peritonei Following Ovarian Immature Teratoma: A Case Report And Literature Review, Osman Türkmen, Serra Akar İnan, Serap Akbay, Mohammad İbrahi̇m Hali̇lzade, İnci̇ Hali̇lzade, Özlem Moraloğlu Teki̇n

Turkish Journal of Medical Sciences

Background/aim: Growing teratoma syndrome (GTS) is marked by the reduction in serum tumor markers, despite the growth of a benign mature teratomatous mass after chemotherapy treatment for germ cell tumors. Gliomatosis Peritonei (GP) is often seen with ovarian teratomas, involving the spread of mature glial tissue on the peritoneum. The coexistence of GP with GTS following treatment for ovarian immature teratoma (IMT) is particularly rare with about 20 cases reported thus far.Case: A 25-year-old patient underwent surgical removal of an adnexal mass. On paraffin pathology, she was deemed to have stage III A grade 3 ovarian IMT with parametrial involvement. …


Factors Associated With Morbidity Of Totally Implantable Venous Access Device In Patients With Breast Cancer, Burak İlhan, Berkay Kiliç Dec 2024

Factors Associated With Morbidity Of Totally Implantable Venous Access Device In Patients With Breast Cancer, Burak İlhan, Berkay Kiliç

Turkish Journal of Medical Sciences

Background/aim: To investigate the possible morbidities associated with the implantation of a totally implantable venous access device (TIVAD) in breast cancer (BC) patients.Materials and methods: Clinical data and developed complications in 546 BC patients with TIVAD between 2017 and 2021 were analyzed retrospectively. Among these patients, 524 (96.0%) patients who underwent TIVAD implantation via the right subclavian vein (SCV) route were examined separately.Results: The mean patient age was 56.1±11.4 years, and the mean patient body mass index was 25.3±6.5. The incidence of early complications was 2.3% (12 cases), and late complications were 2.6% (14 cases). Among these complications, 10 (1.9%) …


Transition Of Patients With Systemic Lupus Erythematosus From Pediatric To Adult-Oriented Rheumatology Care, Seher Şener, Gözde Yardimci, Ezgi̇ Batu, Levent Kiliç, Ümmüşen Kaya Akça, Müşerref Kasap Cüceoğlu, Zeynep Balik, Özge Başaran, Yelda Bi̇lgi̇ner, Şule Apraş Bi̇lgen, Seza Özen Dec 2024

Transition Of Patients With Systemic Lupus Erythematosus From Pediatric To Adult-Oriented Rheumatology Care, Seher Şener, Gözde Yardimci, Ezgi̇ Batu, Levent Kiliç, Ümmüşen Kaya Akça, Müşerref Kasap Cüceoğlu, Zeynep Balik, Özge Başaran, Yelda Bi̇lgi̇ner, Şule Apraş Bi̇lgen, Seza Özen

Turkish Journal of Medical Sciences

Background/aim: The transition from pediatric to adult-oriented care for individuals with juvenile-onset systemic lupus erythematosus (SLE) poses significant challenges. This study aims to assess the outcomes of transitioning patients with juvenile-onset SLE from pediatric to adult-oriented care.Materials and Methods: Patients with juvenile-onset SLE were included. They were transferred in face-to-face meetings where at least one pediatric rheumatologist and one adult rheumatologist were present (the transition time: October-December 2020).Results: The median (25th-75th percentiles) age at diagnosis and the time of the first examination at an adult-oriented rheumatology department of 65 SLE patients were 14.3 (10.9-15.1) years and 19.2 (18.5-20.4) years, respectively …


A New Scoring In Differential Diagnosis: Multisystem Inflammatory Syndrome Or Adenovirus Infection?, Mustafa Gençeli̇, Talha Üstüntaş, Özge Akcan, Si̇nan Saylik, Fati̇h Ercan, Sevgi̇ Pekcan, Si̇pi̇l Gençeli̇, Sevgi̇ Durmuş, Mustafa Argun Dec 2024

A New Scoring In Differential Diagnosis: Multisystem Inflammatory Syndrome Or Adenovirus Infection?, Mustafa Gençeli̇, Talha Üstüntaş, Özge Akcan, Si̇nan Saylik, Fati̇h Ercan, Sevgi̇ Pekcan, Si̇pi̇l Gençeli̇, Sevgi̇ Durmuş, Mustafa Argun

Turkish Journal of Medical Sciences

Background/aim: Differentiating multisystem inflammatory syndrome in children (MIS-C) from adenovirus infection (AI) can be challenging due to similar clinical and laboratory findings. This study aimed to identify distinguishing characteristics and develop a scoring system to facilitate accurate diagnosis.Materials and methods: A comprehensive review of medical records was undertaken for 108 MIS-C cases and 259 patients with confirmed AI. A comparison of laboratory data and clinical findings was conducted across patient groups through appropriate statistical tests.Results: MIS-C patients were significantly older than AI patients (p<0.001). Diarrhea, rash, abdominal pain, vomiting, non-exudative conjunctivitis, lymphadenopathy tachycardia, bradycardia, hypotension, hypoxia seizures, agitation, headache, and altered consciousness symptoms were more frequently associated with MIS-C (p<0.001), while cough and runny nose were significantly more common in AI (p<0.001). Lymphopenia and thrombocytopenia were more prevalent in MIS-C patients (p<0.001). AI and MIS-C were scored by giving 1 point each to the parameters that created the difference. For AI, ≤60 months, presence of cough, runny nose and absence of diarrhea, rash, abdominal pain, vomiting, non-exudative conjunctivitis, lymphadenopathy, tachycardia, bradycardia, hypotension, hypoxia seizures, agitation, headache, and altered consciousness, lymphopenia, thrombocytopenia and CRP <124.5 mg/L were determined as each parameter plus one point. A total score above 14 could predict AI with a high degree of accuracy sensitivity values stood at around 97.5% and specificity at 92.6%.Conclusion: The proposed inpatient scoring system, when used in conjunction with polymerase chain reaction testing, may improve the early differentiation of AI and MIS-C. This approach could help reduce unnecessary testing and optimize resource allocation. Further research with larger samples should investigate this novel scoring system to establish its reliability and generalizability.


Implementation Of Written Asthma Action Plan Among Asthma Patients In Türkiye: A Multicenter, Cross-Sectional, Descriptive Study, Kurtuluş Aksu, Gürgün Tuğçe Vural Solak, Pinar Mutlu, Levent Cem Mutlu, Görkem Vayişoğlu Şahi̇n, Burcu Yormaz, Ayli̇n Çapraz, Ezgi̇ Erdem Türe, Yavuzalp Solak, Funda Aksu Dec 2024

Implementation Of Written Asthma Action Plan Among Asthma Patients In Türkiye: A Multicenter, Cross-Sectional, Descriptive Study, Kurtuluş Aksu, Gürgün Tuğçe Vural Solak, Pinar Mutlu, Levent Cem Mutlu, Görkem Vayişoğlu Şahi̇n, Burcu Yormaz, Ayli̇n Çapraz, Ezgi̇ Erdem Türe, Yavuzalp Solak, Funda Aksu

Turkish Journal of Medical Sciences

Background/aim: In our country, there is no data on whether the clinicians give an asthma action plan to implement to patients followed up with a diagnosis of asthma, and whether patients can manage their treatment according to this plan. The present study aimed to determine the use of asthma action plans in our country and the awareness levels of patients about the plan.Materials and methods: Multicenter, cross-sectional descriptive study was conducted in outpatient immunology and allergy and pulmonology clinics of secondary and tertiary health-care centers. Adults asthmatics filled out a case registration form regarding age, gender, educational status, duration of …


Evaluation Of The Update On Screening For Retinopathy Of Prematurity In A Tertiary Care Center In Türkiye With Retrospective Cohort, Emi̇ne Kaya Güner, Duygu İnci̇ Bozbiyik Dec 2024

Evaluation Of The Update On Screening For Retinopathy Of Prematurity In A Tertiary Care Center In Türkiye With Retrospective Cohort, Emi̇ne Kaya Güner, Duygu İnci̇ Bozbiyik

Turkish Journal of Medical Sciences

Background/aim: In Turkey, recommendations for screening for retinopathy of prematurity (ROP) have been updated in 2021. Herein, we aimed to present detailed data on the infants included in the screening according to the new criteria and evaluate whether these changes benefit in detecting severe ROP.Materials and Methods: Our hospital's medical records of babies screened for ROP between July 2019 - July 2021 and August 2021 - August 2023 were retrospectively examined. Gestational age (GA), birth weight (BW), gender of the babies, whether there was a multiple pregnancy, ROP examination results, the most advanced ROP level and time, and ROP treatment …


Rare Stat3 Haplotypes Cause A Predisposition To Develop Congenital Anomalies Of The Kidney And Urinary Tract Disorder, Mert Polat, Feri̇de Şahi̇n, Esra Baskin, Uğur Toprak, Kaan Gülleroğlu, Mehmet Haberal, Yunus Terzi̇ Dec 2024

Rare Stat3 Haplotypes Cause A Predisposition To Develop Congenital Anomalies Of The Kidney And Urinary Tract Disorder, Mert Polat, Feri̇de Şahi̇n, Esra Baskin, Uğur Toprak, Kaan Gülleroğlu, Mehmet Haberal, Yunus Terzi̇

Turkish Journal of Medical Sciences

Background/aimCongenital anomalies of the kidney and urinary tract (CAKUT) are characterized by renal developmental disorders in the embryonic period. STAT3 is a member of the STAT protein family. The members of this protein family play roles in various cellular mechanisms, such as the early stages of embryonic development, kidney development, and renal diseases. This study aims to determine the frequency of STAT3 rs1053004, rs744166, rs3816769, and rs4796793 polymorphisms in individuals with CAKUT disease.Materials and methodsTwo of the four polymorphisms, rs744166 (c.-1-13666T>C, NM_001369512.1) and rs4796793 ( c.-1915C>G, NM_001369512.1), were analyzed by a polymerase chain reaction and restriction fragment length …


Evaluation Of The Efficacy Of Transfer Energy Capacitive And Resistive Therapy In Patients With Knee Osteoarthritis, Özge Tezen, Emi̇ne Esra Bi̇li̇r, Öznur Uzun, Duygu Yaniktaş, Başak Şentürk, Evren Yaşar Dec 2024

Evaluation Of The Efficacy Of Transfer Energy Capacitive And Resistive Therapy In Patients With Knee Osteoarthritis, Özge Tezen, Emi̇ne Esra Bi̇li̇r, Öznur Uzun, Duygu Yaniktaş, Başak Şentürk, Evren Yaşar

Turkish Journal of Medical Sciences

Background/aim: The aim of present study was to investigate the treatment efficacy of transfer energy capacitive and resistive (TECAR) therapy, a modern application that has been increasingly used in recent years, compared to conventional physical therapy (CPT) applications in the treatment of knee osteoarthritis, according to the evaluation of clinical findings of patients.Materials and methods: A total of 54 patients, aged between 40 and 75 years, were randomly divided into two groups. Both groups received CPT. Group 2 received TECAR therapy in addition to CPT, applied three times a week for two weeks, for a total of 6 sessions. All …


High Sacral Slope, Lumbar Lordosis, And Sacral Slope-To-Pelvic Incidence Ratio Are Associated With New Bone Formation In Ankylosing Spondylitis, Aysun Aksoy, Cemal Gündoğmuş, Mehmet Kesi̇mer, Kemal Nas, İkram Duman, Gazanfer Eki̇nci̇, Murat Bezer, Pami̇r Atagündüz Dec 2024

High Sacral Slope, Lumbar Lordosis, And Sacral Slope-To-Pelvic Incidence Ratio Are Associated With New Bone Formation In Ankylosing Spondylitis, Aysun Aksoy, Cemal Gündoğmuş, Mehmet Kesi̇mer, Kemal Nas, İkram Duman, Gazanfer Eki̇nci̇, Murat Bezer, Pami̇r Atagündüz

Turkish Journal of Medical Sciences

Background/aim: Syndesmophyte formation appears to be site specific in Ankylosing spondylitis(AS),and new bone formation seems to occur in regions of micro-trauma that are prone to tensile forces.Pelvic and spinal parameters are unique for individuals. Pelvic tilt and sacral slope are important anatomical features that compensate in harmony in keeping the sagittal balance. After puberty, the sacral slope shapes the lumbar lordosis, whereas the pelvic incidence is set to an individual constant. This study aims to analyze the properties of pelvic parameters in AS patients with and without syndesmophyte formation in the spine after 15years of disease duration.Materials and methods:Whole spine …


Comparison Of Rigid And Elastic Registration Methods In Software-Based Targeted Prostate Biopsy: A Multi-Center Cohort Study, Serhat Çeti̇n, Serdar Çeli̇k, Murat Koparal, Güven Aslan, Sertaç Yazici, Bahadir Şahi̇n, Si̇nan Sözen, Levent Türkeri̇ Dec 2024

Comparison Of Rigid And Elastic Registration Methods In Software-Based Targeted Prostate Biopsy: A Multi-Center Cohort Study, Serhat Çeti̇n, Serdar Çeli̇k, Murat Koparal, Güven Aslan, Sertaç Yazici, Bahadir Şahi̇n, Si̇nan Sözen, Levent Türkeri̇

Turkish Journal of Medical Sciences

Background/Aim: This study aims to compare the success rates of rigid registration (RR) and elastic registration (ER)systems in diagnosing all cancers and clinically significant prostate cancer (csPC) in software-based targeted prostate biopsies (TPBs) by performing matching analysis.Materials and Methods: The data of 2,061 patients from six centers where software-based TPB was performed were used. All cancer and csPC detection rates of the RR and ER systems were compared following Mahalanobis distance matching within the propensity score caliper method. Logistic regression analysis was applied to identify factors predicting clinically insignificant prostate cancer (ciPC) and csPC diagnoses. Additionally, the International Society of …


Evaluation Of The Relationship Between Type Of Menopause And Cognitive Functions, Meltem Durakli Ulukök, Ufuk Atlihan, Onur Yavuz Dec 2024

Evaluation Of The Relationship Between Type Of Menopause And Cognitive Functions, Meltem Durakli Ulukök, Ufuk Atlihan, Onur Yavuz

Turkish Journal of Medical Sciences

Background/aim:Menopause is often accompanied by neurological symptoms, including cognitive difficulties, especially with memory and attention. In the present study, the purpose was to examine the relationship between the timing of menopause and the cognitive performance of menopausal patients who applied to our neurology clinic with complaints of forgetfulness.Materials and methods: The data of 538 women who applied to the neurology clinic with complaints of forgetfulness between January 2018 and January 2024and underwent neuropsychological evaluations were scanned retrospectively. A total of 96 patients who applied to neurology and menopause clinics were included in the study.Results: In the present study, attention orientation, …


Achillea Millefolium Ameliorates Doxorubicin-Induced Renal Injury Via Inhibition Of Oxidative Stress And Inflammation In Rats, Mohammed Shaiea, Yi̇mi̇ng Dong, Saleh Alomisy, Hassan Al-Mahbashi, Guozhong Zhang, Chuan Wang Dec 2024

Achillea Millefolium Ameliorates Doxorubicin-Induced Renal Injury Via Inhibition Of Oxidative Stress And Inflammation In Rats, Mohammed Shaiea, Yi̇mi̇ng Dong, Saleh Alomisy, Hassan Al-Mahbashi, Guozhong Zhang, Chuan Wang

Turkish Journal of Medical Sciences

Background/aim: Doxorubicin (Dox) is a potent anticancer medication. Nevertheless, due to nephrotoxicity, its clinical application is restricted. Achillea millefolium (AM) is a traditional medicine used against several disturbances, including kidney disorders. Therefore, this work aims to investigate the preventative properties of AM extract (AME) and their mechanisms against nephrotoxicity caused by Dox in rats. Materials and methods: The rats were assigned randomly to six groups, including a control group, Dox group (5 mg/kg/week via i.p. for 4 weeks), two groups, AME (100 or 200 mg/kg, orally for 28 days), and the last two groups, Dox+ AME (100 or 200 mg/kg, …


The Difference Between Clinical Significance And Statistical Significance: An Important Distinction For Clinical Research, Sadi̇ Elasan Dec 2024

The Difference Between Clinical Significance And Statistical Significance: An Important Distinction For Clinical Research, Sadi̇ Elasan

Turkish Journal of Medical Sciences

No abstract provided.


Response Of Mucinous Breast Carcinoma To Neoadjuvant Chemotherapy, Berkay Kiliç, Burak İlhan Dec 2024

Response Of Mucinous Breast Carcinoma To Neoadjuvant Chemotherapy, Berkay Kiliç, Burak İlhan

Turkish Journal of Medical Sciences

Background/aim: Mucinous breast carcinoma (MC) is thought to be a favorable-differentiated form of invasive breast cancer and is rarely preferred for neoadjuvant chemotherapy (NAC). The study aimed to define the response of MCs to NAC.Materials and methods: The study reviewed the demographic, clinicopathologic characteristics, management, and follow-up data of 70 patients diagnosed with MC between May 2010 to December 2020 by examining patients’ historical files and oncology records.Results: The median age, tumor size, and follow-up period of patients were respectively 52.9 (range 32 to 87) years, 25.8 (range 8 to 88) mm, and 61.5 (range 18 to 143) months. Out …


The Relationship Between Drug Induced Immunogenicity And Hypersensitivity Reactions And Skin Tests Related To Infliximab, Etanercept And Adalimumab In Patients With Rheumatoid Arthritis And Ankylosing Spondylitis, Alper Doğanci, Şebnem Ataman, Ali̇ Özdemi̇rel, Recep Seçki̇n, Ayşe Yalçin, Sevi̇m Bavbek Dec 2024

The Relationship Between Drug Induced Immunogenicity And Hypersensitivity Reactions And Skin Tests Related To Infliximab, Etanercept And Adalimumab In Patients With Rheumatoid Arthritis And Ankylosing Spondylitis, Alper Doğanci, Şebnem Ataman, Ali̇ Özdemi̇rel, Recep Seçki̇n, Ayşe Yalçin, Sevi̇m Bavbek

Turkish Journal of Medical Sciences

Background and aim: We aimed to investigate the relationship between serum anti-drug antibody (ADAb), hypersensitivity reactions (HSRs) to anti-tumor necrosis factors (anti-TNFs) drugs and to detect the role of skin tests in the diagnosis of HSRs against anti-TNFs.Material and methods: 69 ankylosing spondilitis (AS) and 46 rheumatoid artritis (RA) patients using infliximab, adalimumab, and etanercept were enrolled. Disease activity scores for AS and RA patients were assessed. Serum levels of anti-TNFs and ADAb to these agents were measured with the ELISA.These blood samples were taken 24 hours before the next drug dose.The patients with anti-TNF-associated HSRs were evaluated with a …


Oligosaccharides, Onion Peel, And Essential Oils As Feed Additives In The Diet Of Dairycattle: In Vitro Fermentation, Greenhouse Gases, Ruminal Nutrient Degradability, Andvolatile Fatty Acid Production, Kelechi A. Ike, Oludotun O. Adelusi, Joel O. Alabi, Lydia K. Olagunju, Michael Wuaku, Chika C. Anotaenwere, Deborah O. Okedoyin, Oluteru E. Orimaye, Deandrea Gray, Peter A. Dele, Kiran Subedi, Ahmed E. Kholif, Uchenna Y. Anele Dec 2024

Oligosaccharides, Onion Peel, And Essential Oils As Feed Additives In The Diet Of Dairycattle: In Vitro Fermentation, Greenhouse Gases, Ruminal Nutrient Degradability, Andvolatile Fatty Acid Production, Kelechi A. Ike, Oludotun O. Adelusi, Joel O. Alabi, Lydia K. Olagunju, Michael Wuaku, Chika C. Anotaenwere, Deborah O. Okedoyin, Oluteru E. Orimaye, Deandrea Gray, Peter A. Dele, Kiran Subedi, Ahmed E. Kholif, Uchenna Y. Anele

Turkish Journal of Veterinary & Animal Sciences

This study investigated the effect of inclusion of dietary oligosaccharides, onion peel, and an essential oil blend (EOB; containing anise, clove, oregano, cedarwood, and ginger in the ratio 4:2:2:1:1) individually and in combinations in the total mixed ration of dairy cattle on in vitro gas production (GP), dry matter disappearance (DMD), fiber fraction disappearance, and total and individual volatile fatty acid (VFA) production. EOB was used at 200 μL g–1 of feed while the other additives were administered at 3% of the feed on a dry matter basis. The in vitro batch culture technique was used for this experiment and …


Honeybee Biodiversity Based On Five Mitochondrial Genes And New Evidence For Differentsublineages In Türkiye, Meral Kekeçoğlu, Songül Bi̇r, Merve Kambur Acar, Rustem Ilyasov Dec 2024

Honeybee Biodiversity Based On Five Mitochondrial Genes And New Evidence For Differentsublineages In Türkiye, Meral Kekeçoğlu, Songül Bi̇r, Merve Kambur Acar, Rustem Ilyasov

Turkish Journal of Veterinary & Animal Sciences

In this study, the genetic structure of honey bee populations in Türkiye was analyzed using eleven restriction endonuclease enzymes targeting the COI-COII, COI, 16S rDNA, ND5, and CYT B genes. A total of 553 worker honey bee samples were collected from 43 different districts across Türkiye, as well as from Greece, Bulgaria, and Georgia, neighboring countries of Türkiye. Analysis of the COI region using the HinfI restriction enzyme revealed the presence of two mitotypes. Type 1 was the predominant type in Türkiye, while Type 2 was detected exclusively in Hatay, a province in the southern part of the country. Notably, …


Phenotypic And Molecular Characterization And Antimicrobial Susceptibility Pattern Of Pasteurella And Mannheimia Species Obtained From Cattle And Sheep With Pneumonia, Eli̇f Karadeni̇z Pütür, Fati̇h Büyük, Yaren Ersoy Dec 2024

Phenotypic And Molecular Characterization And Antimicrobial Susceptibility Pattern Of Pasteurella And Mannheimia Species Obtained From Cattle And Sheep With Pneumonia, Eli̇f Karadeni̇z Pütür, Fati̇h Büyük, Yaren Ersoy

Turkish Journal of Veterinary & Animal Sciences

Among the heterogeneous Pasteurellaceae family, Pasteurella multocida and Mannheimia haemolytica are the pathogenic species that cause enzootic pneumonia in cattle and sheep. This study aimed to characterise Pasteurella and Mannheimia species obtained from pneumonia cases in cattle and sheep. 100 cattle and 100 sheep lungs diagnosed with infectious pneumonia as a result of histopathological examination were analyzed for Pasteurellaceae members by phenotypic methods, VITEK 2 Compact system and PCR. Antibiotic susceptibilities and phylogenetic analysis of the isolates were done by VITEK 2 Compact System and 16S rRNA-PCR, respectively. Seven Pasteurella multocida and 9 Mannheimia haemolytica were identified. All strains were …