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Articles 3241 - 3270 of 8080
Full-Text Articles in Medicine and Health Sciences
Ophthalmic Pathologies In Female Subjects With Bilateralcongenital Sensorineural Hearing Loss, Mehmet Talay Köylü, Gökçen Gökçe, Güngör Sobaci, Fahretti̇n Güven Oysul, Dorukcan Akincioğlu
Ophthalmic Pathologies In Female Subjects With Bilateralcongenital Sensorineural Hearing Loss, Mehmet Talay Köylü, Gökçen Gökçe, Güngör Sobaci, Fahretti̇n Güven Oysul, Dorukcan Akincioğlu
Turkish Journal of Medical Sciences
Background/aim: The high prevalence of ophthalmologic pathologies in hearing-disabled subjects necessitates early screening of other sensory deficits, especially visual function. The aim of this study is to determine the frequency and clinical characteristics of ophthalmic pathologies in patients with congenital bilateral sensorineural hearing loss (SNHL). Materials and methods: This descriptive study is a prospective analysis of 78 young female SNHL subjects who were examined at a tertiary care university hospital with a detailed ophthalmic examination, including electroretinography (ERG) and visual field tests as needed. Results: The mean age was 19.00 ± 1.69 years (range: 15 to 24 years). A total …
Effects Of Immunosuppressive Drugs On Oral Mucosa In Patients With Behçet?S Disease: Cytomorphological And Cytopathological Assessment, Eda Di̇yarbakir, Adem Kara, Sadullah Keleş, Jale Selli̇, Handan Bi̇len, Ni̇lnur Eyerci̇, Necmetti̇n Akdeni̇z, Orhan Ateş, Hasan Doğan
Effects Of Immunosuppressive Drugs On Oral Mucosa In Patients With Behçet?S Disease: Cytomorphological And Cytopathological Assessment, Eda Di̇yarbakir, Adem Kara, Sadullah Keleş, Jale Selli̇, Handan Bi̇len, Ni̇lnur Eyerci̇, Necmetti̇n Akdeni̇z, Orhan Ateş, Hasan Doğan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate cytomorphological and cytopathological changes in oral exfoliated smears collected from immunosuppressed patients with Behçet's disease (BD) using stereological methods. Materials and methods: For cytomorphometric analysis, mucosal cell smears were obtained from the buccal mucosa and the floor of the mouths of BD patients treated with immunosuppressive drugs and from healthy volunteers. All mucosal smears from the patients and the healthy volunteers were stained using the Papanicolaou method and examined cytopathologically under light microscopy and cytomorphologically via the stereological nucleator method. Results: The cytomorphological analysis revealed 3 types of mucosal cells, with …
Intrabone Marrow Injection Enhances Placental Mesenchymal Stem Cellmediated Support Of Hematopoiesis In Mice, Ya Hong Yuan, Chun Fang Zhou, Zhi Yong Lu, Xiao Li Wang, Yan Ding, Dongsheng Li
Intrabone Marrow Injection Enhances Placental Mesenchymal Stem Cellmediated Support Of Hematopoiesis In Mice, Ya Hong Yuan, Chun Fang Zhou, Zhi Yong Lu, Xiao Li Wang, Yan Ding, Dongsheng Li
Turkish Journal of Medical Sciences
Background/aim: In order to determine the synergistic effects of human placental mesenchymal stem cells (PMSCs) on hematopoiesis in vivo, we compared the intrabone marrow injection (IBMI) with the conventional intravenous injection (IVI). Materials and methods: C57BL/6 recipient mice conditioned with lethal doses of irradiation were transplanted with bone marrow mononuclear cells (MNCs) and bone marrow-derived mesenchymal stem cells (BMSCs) from BALB/c mice by IBMI or IVI. NOD/SCID recipient mice conditioned with sublethal doses of irradiation were transplanted with human umbilical cord blood MNCs (UCB-MNCs) and PMSCs by IBMI or IVI. Results: The number of hematopoietic cells was significantly higher in …
The Effect Of Proanthocyanidin On Formaldehyde-Induced Toxicity In Rat Testes, Eni̇s Uluçam, Elvan Bakar
The Effect Of Proanthocyanidin On Formaldehyde-Induced Toxicity In Rat Testes, Eni̇s Uluçam, Elvan Bakar
Turkish Journal of Medical Sciences
Background/aim: This study investigated the effect of proanthocyanidin (PA) against formaldehyde (FA)-induced lipid peroxidation damage and morphological changes in rat testes. Materials and methods: Twenty-one Wistar albino rats were randomized into 3 groups: control, FA, and FA + PA groups. Plasma and tissue malondialdehyde (MDA) and total sialic acid (TSA) levels were measured. Testes tissues were observed by light and electron microscopy. Results: TSA (plasma and tissue) levels decreased and MDA (plasma) significantly increased (P < 0.05) in rats treated with FA compared to the controls. Tissue MDA levels were not significantly different. Several necrotic changes were observed in testes tissues by light and electron microscopy. Disordering in epithelia of seminiferous tubules, vacuolization between germinal epithelium cells, and separated basement membranes were observed by light microscope. Immunopositivity in Leydig cells decreased in the FA group (P < 0.05). In the FA + PA group there were more immune Leydig cells reacting immune-positively than in the FA group (P < 0.05). Ultrastructurally, FA also caused disorganization and loss of mitochondrial cristae, and dilatation in endoplasmic reticulum in testes. Conclusion: The results suggest that PA has a protective effect on FA toxicity in testes.
Apitherapy Products Enhance The Recovery Of Ccl4-Induced Hepatic Damages In Rats, Özlem Saral, Oktay Yildiz, Rezzan Ali̇yazicioğlu, Esi̇n Yuluğ, Si̇nan Canpolat, Ferhat Öztürk, Sevgi̇ Kolayli
Apitherapy Products Enhance The Recovery Of Ccl4-Induced Hepatic Damages In Rats, Özlem Saral, Oktay Yildiz, Rezzan Ali̇yazicioğlu, Esi̇n Yuluğ, Si̇nan Canpolat, Ferhat Öztürk, Sevgi̇ Kolayli
Turkish Journal of Medical Sciences
Background/aim: Our objective was to identify the antioxidant properties of honeybee products from Turkey, chestnut honey, pollen, propolis, and royal jelly, and their hepatoprotective activity against CCl4-induced hepatic damage in rats. Materials and methods: Animals were fed with honeybee products for 7 days following CCl4 injection. Development of liver damage and oxidative stress were monitored by measuring the activities of the enzymes alanine transaminase, aspartate transaminase, malondialdehyde, superoxide dismutase, and catalase. Antioxidant capacities of the bee products were identified using FRAP and DPPH assays, as well as by measuring total phenolic and flavonoid contents. Results: The antioxidant activities of the …
Comparison Of A Real-Time Polymerase Chain Reaction-Based System And Erlich-Ziehl-Neelsen Method With Culture In The Identification Of Mycobacterium Tuberculosis, Kemal Bi̇lgi̇n, Kerametti̇n Yanik, Adi̇l Karadağ, Hakan Odabaşi, Hakan Taş, Murat Günaydin
Comparison Of A Real-Time Polymerase Chain Reaction-Based System And Erlich-Ziehl-Neelsen Method With Culture In The Identification Of Mycobacterium Tuberculosis, Kemal Bi̇lgi̇n, Kerametti̇n Yanik, Adi̇l Karadağ, Hakan Odabaşi, Hakan Taş, Murat Günaydin
Turkish Journal of Medical Sciences
Background/aims: Ankaferd blood stopper (ABS) is a mixture of certain ratios of 5 different plant roots (Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica). The aim of this study is to evaluate the histopathological effects of ABS on articular cartilage in vitro. Materials and methods: Twenty-one albino Sprague Dawley rats were randomly allocated to 3 groups: 0.1 mL of saline was injected in the first group, 0.1 mL of ABS was injected in the second group, and 0.1 mL of blood and 0.1 mL of ABS were injected in the third group. One month later all rats …
Evaluation Of New Multiplex Pcr Primers For The Identification Ofplasmodium Species Found In Sabah, Malaysia, Cheronie Shely Stanis, Beng Kah Song, Tock Hing Chua, Yee Ling Lau, Jenarun Jelip
Evaluation Of New Multiplex Pcr Primers For The Identification Ofplasmodium Species Found In Sabah, Malaysia, Cheronie Shely Stanis, Beng Kah Song, Tock Hing Chua, Yee Ling Lau, Jenarun Jelip
Turkish Journal of Medical Sciences
Background/aim: Malaria is a major public health problem, especially in the Southeast Asia region, caused by 5 species of Plasmodium (P. falciparum, P. vivax, P. malariae, P. ovale, and P. knowlesi). The aim of this study was to compare parasite species identification methods using the new multiplex polymerase chain reaction (PCR) against nested PCR and microscopy. Materials and methods: Blood samples on filter papers were subject to conventional PCR methods using primers designed by us in multiplex PCR and previously designed primers of nested PCR. Both sets of results were compared with microscopic identification. Results: Of the 129 samples identified …
Quantitative Comparison Of Immunohistochemical And Pcr Analysis Of Midkine Expression In Breast Cancer Types And Serum Midkine Level, Hülya Çeti̇n Sorkun, Meti̇n Akbulut, Yaşar Enli̇, Emre Tepeli̇, Sevgi̇ Özkan, Ergün Erdem
Quantitative Comparison Of Immunohistochemical And Pcr Analysis Of Midkine Expression In Breast Cancer Types And Serum Midkine Level, Hülya Çeti̇n Sorkun, Meti̇n Akbulut, Yaşar Enli̇, Emre Tepeli̇, Sevgi̇ Özkan, Ergün Erdem
Turkish Journal of Medical Sciences
Background/aim: Midkine (MK), a heparin-binding growth factor, has an important role in cancer progression. The aim of this study was to determine MK expression in breast tissue and the preoperative and postoperative serum levels of patients with breast cancer. Materials and methods: Sixty-one patients with breast cancer participated in our study. The MK serum levels were measured pre- and postoperatively for these patients. We also analyzed breast tissues of the 61 patients immunohistochemically. We examined serum midkine levels in 49 healthy volunteers. Results: MK expression was observed in 44 (72.1%) of 61 breast cancer patients. In breast cancer patients the …
Evaluation Of Brainstem Auditory Evoked Potentials And Their Relationshipwith Levels Of Thyroid Autoantibodies In Patients With Vitiligo, İlhan Çeçen, Ayşe Serap Karadağ, Temel Tombul, Serap Güneş Bi̇lgi̇li̇, Ömer Çalka, Ahmet Zübeyi̇r Burakgazi̇
Evaluation Of Brainstem Auditory Evoked Potentials And Their Relationshipwith Levels Of Thyroid Autoantibodies In Patients With Vitiligo, İlhan Çeçen, Ayşe Serap Karadağ, Temel Tombul, Serap Güneş Bi̇lgi̇li̇, Ömer Çalka, Ahmet Zübeyi̇r Burakgazi̇
Turkish Journal of Medical Sciences
Background/aim: Vitiligo is a common depigmenting disorder. The damage can also occur in similar ways to melanocytes within other organs. We evaluated the brainstem and auditory pathway functions by evaluating brainstem auditory evoked potentials (BAEPs) and whether there is any relationship between auditory functions and autoimmunity. Materials and methods: Forty patients with vitiligo and 20 healthy volunteers were enrolled. Thyroid functions and autoantibodies were examined and BAEP tests were assessed by a neurologist. Results: Antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-TGA) antibody positivity was higher in the patient group (P < 0.05). A negative correlation was detected between anti-TPO and lead III, IV, and V latency and I?III interpeak latency (IPL) of the right ear together with lead IV latency and I?V IPL of the left ear in the patient group. When each BAEP parameter was compared between the two groups, more abnormalities were detected in the V latency and III?V IPL of the left ear together with IV and V latency of the right ear. Conclusion: In this study the presence of a correlation between increased anti-TGA and anti-TPO levels and BAEP parameters may be related to an autoimmune-mediated mechanism. However, further studies are needed to be performed in a large patient series.
Mefv Mutations In Iranian Azari Turkish Patients With Henoch?Schönlein Purpura, Mortaza Bonyadi, Mahdieh Younesi, Mandana Rafeey, Mahnaz Sadeghi_Shabestari, Fakhrossadat Mortazavi
Mefv Mutations In Iranian Azari Turkish Patients With Henoch?Schönlein Purpura, Mortaza Bonyadi, Mahdieh Younesi, Mandana Rafeey, Mahnaz Sadeghi_Shabestari, Fakhrossadat Mortazavi
Turkish Journal of Medical Sciences
Background/aim: The aim of the current study was to screen the rate of MEFV mutations in Henoch?Schönlein purpura (HSP) and to investigate the association of these mutations plus clinical symptoms with HSP disease in the Iranian Azari Turkish ethnic group. Materials and methods: The study groups included 40 unrelated HSP patients and 200 apparently healthy people without any kind of inflammatory diseases as a control group. Molecular screening was performed for eight main mutations, namely M694V, M694I, M680I, V726A, E148Q, R761H, P396S, and R408Q, using polymerase chain reaction (PCR), restriction fragment length polymorphism (RFLP), and sequencing. Results: Out of the …
The Relationship Between Blood Urea Nitrogen Levels And Metabolic, Biochemical, And Histopathologic Findings Of Nondiabetic, Nonhypertensive Patients With Nonalcoholic Fatty Liver Disease, Cemal Nuri̇ Erçi̇n, Teoman Doğru, Gürkan Çelebi̇, Hasan Gürel, Hali̇l Genç, Erdi̇m Sertoğlu, Sai̇t Bağci
The Relationship Between Blood Urea Nitrogen Levels And Metabolic, Biochemical, And Histopathologic Findings Of Nondiabetic, Nonhypertensive Patients With Nonalcoholic Fatty Liver Disease, Cemal Nuri̇ Erçi̇n, Teoman Doğru, Gürkan Çelebi̇, Hasan Gürel, Hali̇l Genç, Erdi̇m Sertoğlu, Sai̇t Bağci
Turkish Journal of Medical Sciences
Background/aim: Nonalcoholic fatty liver disease (NAFLD) is known as the most common cause of chronic liver disease. It is accepted that the leading cause of death in patients with NAFLD is from coronary events. Blood urea nitrogen (BUN) was used as a prognostic indicator for cardiovascular disease. We aimed to investigate the relationship between BUN levels and metabolic, biochemical, and histopathologic findings of nondiabetic patients with NAFLD. Materials and methods: A total of 195 male patients with biopsy proven NAFLD and 82 healthy controls with normal liver and renal function tests and normal abdominal ultrasonography were enrolled in the study. …
The Effects Of Conscious Sedation With Nitrous Oxide/Oxygen On Cognitive Functions, Sara Samur Ergüven, Ertan Ali̇ Deli̇lbaşi, Berri̇n Işik, Ferhunde Öktem
The Effects Of Conscious Sedation With Nitrous Oxide/Oxygen On Cognitive Functions, Sara Samur Ergüven, Ertan Ali̇ Deli̇lbaşi, Berri̇n Işik, Ferhunde Öktem
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the effects of conscious sedation with 40% nitrous oxide/oxygen (N2O/O2) on cognitive functions. Materials and methods: Forty dental patients referred to the sedation unit at Gazi University Faculty of Dentistry Department of Oral and Maxillofacial Surgery received a combination of 40% N2O/O2 inhalation for conscious sedation. Psychometric tests were applied three times: before sedation, during sedation, and at the end of the recovery, for assessing cognitive functions. Results: The results of this study showed that the 40% N2O/O2 combination impaired cognitive functions during the conscious sedation. Recovery of most of the …
Comparison Between The Use Of Saline And Seawater For Nasal Obstruction In Children Under 2 Years Of Age With Acute Upper Respiratory Infection, Tüli̇n Köksal, Mehmet Nevzat Çi̇zmeci̇, Davut Bozkaya, Mehmet Kenan Kanburoğlu, Şanliay Şahi̇n, Tuğba Taş, Çi̇ğdem Nükhet Yüksel, Mustafa Mansur Tatli
Comparison Between The Use Of Saline And Seawater For Nasal Obstruction In Children Under 2 Years Of Age With Acute Upper Respiratory Infection, Tüli̇n Köksal, Mehmet Nevzat Çi̇zmeci̇, Davut Bozkaya, Mehmet Kenan Kanburoğlu, Şanliay Şahi̇n, Tuğba Taş, Çi̇ğdem Nükhet Yüksel, Mustafa Mansur Tatli
Turkish Journal of Medical Sciences
Background/aim: The effectiveness of isotonic and hypertonic saline solutions used to open the nasal passage and improve clinical symptoms was compared in children under 2 years of age admitted with the common cold. Materials and methods: The study was performed as a randomized, prospective, and double-blind study. The study included 109 children. The children using saline (0.9%) and seawater (2.3%) as nasal drops (the patient group) and the control group (in which nasal drops were not administered) were compared. Seventy-four patients received nasal drops from package A (seawater) in single days and from package B (physiological saline) in double days. …
Varicocele: Tissue Stress In The Etiology, Ferhat Cüce, Özay Demi̇ray, Uğur Küçük, Hi̇lal Olgun Küçük
Varicocele: Tissue Stress In The Etiology, Ferhat Cüce, Özay Demi̇ray, Uğur Küçük, Hi̇lal Olgun Küçük
Turkish Journal of Medical Sciences
Background/aim: It is accepted that red blood cell distribution width (RDW) is a novel prognostic marker that reflects oxidative stress and chronic inflammation. In this study, we aimed to investigate the correlation between RDW and varicocele, the etiology of which has not fully elucidated yet. This study also aimed to study the mean platelet volume (MPV) values of the patient and control group. Materials and methods: RDW and MPV levels were measured in 50 varicocele subjects (group 1) and 48 healthy controls (group 2) from January 2012 to January 2014, retrospectively. Results: MPV levels were significantly higher in group 1 …
Comparison Of Glomerular Filtration Rate Measurements With The Two-Plasma Sample Technique Using Tc-99m Dtpa And Other Methods In Donor Candidates For Renal Transplantation, Ari̇f Kürşad Ayan, Erhan Varoğlu, Mustafa Keleş, Bedri̇ Seven, Abdullah Uyanik, Ebru Örsal
Comparison Of Glomerular Filtration Rate Measurements With The Two-Plasma Sample Technique Using Tc-99m Dtpa And Other Methods In Donor Candidates For Renal Transplantation, Ari̇f Kürşad Ayan, Erhan Varoğlu, Mustafa Keleş, Bedri̇ Seven, Abdullah Uyanik, Ebru Örsal
Turkish Journal of Medical Sciences
Background/aim: Accurate measurement of glomerular filtration rate (GFR) in the evaluation of renal functions in potential kidney donors is associated with important outcomes for both the donor and recipient. We intended to determine the efficacy of various methods while estimating GFR in potential living kidney donors. Materials and methods: Fifty-three potential kidney donors (31 females, 22 males; mean age: 50.1 years) were included in this study. GFR was estimated simultaneously using the following methods: Gates? method, Cockcroft?Gault (CG) and modification of diet in renal disease (MDRD) prediction equations, and the two-plasma sample (TPS) technique. Using TPS as the reference method, …
The High Prevalence Of Encephalitozoon Intestinalis In Patients Receiving Chemotherapy And Children With Growth Retardation And The Validity Of Real-Time Pcr In Its Diagnosis, Ülfet Çeti̇nkaya, Süleyman Yazar, Sali̇h Kuk, Eda Si̇vcan, Leylagül Kaynar, Duran Arslan, İzzet Şahi̇n
The High Prevalence Of Encephalitozoon Intestinalis In Patients Receiving Chemotherapy And Children With Growth Retardation And The Validity Of Real-Time Pcr In Its Diagnosis, Ülfet Çeti̇nkaya, Süleyman Yazar, Sali̇h Kuk, Eda Si̇vcan, Leylagül Kaynar, Duran Arslan, İzzet Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the presence of Encephalitozoon intestinalis in different patient groups consisting of immunocompromised and immunocompetent individuals. Materials and methods: The stool samples of 100 patients consisting of 25 patients receiving chemotherapy and with acute gastrointestinal complaints, 25 with bone marrow transplant and acute gastrointestinal complaints, 25 with urticaria, and 25 with growth retardation were included in the study. As control groups, 25 subjects without any chronic disease but with acute gastrointestinal complaints and 25 healthy volunteers, making a total of 50 subjects, were included in the study. E. intestinalis was investigated by …
Rectal Or Intramuscular Diclofenac Reduces The Incidence Of Pancreatitis Afterendoscopic Retrograde Cholangiopancreatography, Ramazan Uçar, Murat Biyik, Esma Uçar, İlker Polat, Sami̇ Çi̇fçi̇, Hüseyi̇n Ataseven, Ali̇ Demi̇r
Rectal Or Intramuscular Diclofenac Reduces The Incidence Of Pancreatitis Afterendoscopic Retrograde Cholangiopancreatography, Ramazan Uçar, Murat Biyik, Esma Uçar, İlker Polat, Sami̇ Çi̇fçi̇, Hüseyi̇n Ataseven, Ali̇ Demi̇r
Turkish Journal of Medical Sciences
Background/aim: Acute pancreatitis is the most common adverse event of endoscopic retrograde cholangiopancreatography (ERCP). We aimed to evaluate the efficacy of intramuscular diclofenac sodium for prophylaxis of post-ERCP pancreatitis (PEP) in comparison to the rectal form. Materials and methods: One hundred and fifty consecutive patients who underwent ERCP were enrolled in this single-center, prospective, randomized controlled study. Patients were randomized into three groups. The first group received 75 mg of diclofenac sodium via intramuscular route and the second group received 100 mg of diclofenac sodium rectally 30?90 min before the procedure. The third group served as the control group. Patients …
Macrolide And Lincosamide Resistance In Staphylococcal Clinical Isolates In Nablus, Palestine, Motasem Almasri, Nael Abu Hasan, Naela Sabbah
Macrolide And Lincosamide Resistance In Staphylococcal Clinical Isolates In Nablus, Palestine, Motasem Almasri, Nael Abu Hasan, Naela Sabbah
Turkish Journal of Medical Sciences
Background/aim: Macrolide and lincosamide antibiotics are used for the treatment of staphylococcal infections, especially for penicillin-allergic patients. In the present study, we evaluate the prevalence of resistance to macrolide and lincosamide antibiotics among staphylococci isolates. Materials and methods: A total of 200 staphylococcal clinical isolates were collected from January 2012 to April 2013. Minimal inhibitory concentrations of erythromycin and clindamycin were determined by agar dilution method. An erythromycin-clindamycin induction test was performed for isolates that were only resistant to erythromycin. Representative erythromycin-resistant isolates were examined for erythromycin resistance genes using PCR. Results: Among staphylococci isolates, resistance frequencies of erythromycin and …
Comparison Of The Effects Of Peep Levels On Respiratory Mechanics And Elimination Of Volatile Anesthetic Agents In Patients Undergoing Laparoscopic Cholecystectomy; A Prospective, Randomized, Clinical Trial, Hüsnü Mert Arinalp, Nurten Bakan, Gülşah Karaören, Ömer Torun Şahi̇n, Emre Çeli̇ksoy
Comparison Of The Effects Of Peep Levels On Respiratory Mechanics And Elimination Of Volatile Anesthetic Agents In Patients Undergoing Laparoscopic Cholecystectomy; A Prospective, Randomized, Clinical Trial, Hüsnü Mert Arinalp, Nurten Bakan, Gülşah Karaören, Ömer Torun Şahi̇n, Emre Çeli̇ksoy
Turkish Journal of Medical Sciences
Background/aim: In laparoscopic procedures, intraabdominal carbon dioxide (CO2) insufflation can cause decreased compliance, increased airway resistance, and impaired ventilation-perfusion ratios. We aimed to investigate the effects of intraoperative positive end-expiratory pressure (PEEP) treatment on respiratory dynamics and elimination time of volatile anesthetic agents. Materials and methods: In the present study, 75 ASA I-II patients were randomized into 3 groups to receive 0 cmH2O PEEP (group I), 5 cmH2O PEEP (group II), or 8 cmH2O PEEP (group III). Hemodynamic parameters, peak and plateau inspiratory airway pressures (Ppeak, Pplateau), compliance values, the ratio of the fractions of inspired and expired concentration of …
Effect Of The Application Of Prophylactic Central Compartment Lymph Node Dissectionon Radioiodine Ablation Doses In Patients With Papillary Thyroid Carcinoma, Çi̇ğdem Soydal, Elgi̇n Özkan, Nuri̇ye Özlem Küçük, Kemal Meti̇n Kir
Effect Of The Application Of Prophylactic Central Compartment Lymph Node Dissectionon Radioiodine Ablation Doses In Patients With Papillary Thyroid Carcinoma, Çi̇ğdem Soydal, Elgi̇n Özkan, Nuri̇ye Özlem Küçük, Kemal Meti̇n Kir
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to document the effect of the application of prophylactic central compartment dissection on radioiodine ablation activities for papillary thyroid carcinoma. Materials and methods: This retrospective study included 452 (383 females, 69 males; mean age = 46.69 years, min?max: 13?71) patients who received ablative radioiodine activity between April 2010 and December 2014. The histopathological reports of thyroidectomy and the administered radioiodine activity were evaluated. Frequencies of prophylactic central compartment dissection according to T stage of the primary tumor, detection rate of lymph node metastases, and its effect on radioiodine ablation activities were calculated. Results: …
An Analysis Of The Incidence Of Measles In Turkey Since 1960, Deni̇z Çalişkan, Bi̇rgül Pi̇yal, Recep Akdur, Mi̇ne Esi̇n Ocaktan, Ceylan Yozgatligi̇l
An Analysis Of The Incidence Of Measles In Turkey Since 1960, Deni̇z Çalişkan, Bi̇rgül Pi̇yal, Recep Akdur, Mi̇ne Esi̇n Ocaktan, Ceylan Yozgatligi̇l
Turkish Journal of Medical Sciences
Background/aim: The aims of this study were to evaluate measles incidence and the effect of elimination strategy interventions on the disease from 1960 to 2014 in Turkey. The administration of measles vaccine started in the rural regions in 1970; it was carried out as a campaign along with the National Vaccine Campaign in 1985, and it has been employed as combined measles, mumps, and rubella under the scope of the Measles Elimination Program (MEP) since 2006 in Turkey. While a dramatic decrease in the reporting of measles was observed between 2000 and 2010, the number of the cases has increased …
Reliability And Validity Of The Turkish Version Of Myastheniagravis-Quality Of Life Questionnaire-15 Item, Ni̇da Fatma Taşcilar, Özge Saraçli, Mehmet Ali̇ Kurçer, Handan Ankarali, Ufuk Emre
Reliability And Validity Of The Turkish Version Of Myastheniagravis-Quality Of Life Questionnaire-15 Item, Ni̇da Fatma Taşcilar, Özge Saraçli, Mehmet Ali̇ Kurçer, Handan Ankarali, Ufuk Emre
Turkish Journal of Medical Sciences
Background/aim: The myasthenia gravis-quality of life questionnaire 15 item (MG-QOL15) is a validated, short, and easy to use disease-specific quality of life (QOL) tool in myasthenia gravis. Other than Turkish, a lot of versions of the MG-QOL15 have been used in different languages in different cultures. Therefore, the aim of this study was to translate and construct a validated and adapted Turkish version of the MG-QOL15 [MG-QOL15(T)]. Materials and methods: After translation, back-translation, and comparison of the 2 English versions of the MG-QOL15, it was tested by 22 monolingual healthy individuals and then 23 patients with clinically stable MG. Afterwards, …
The Effectiveness Of A Back School Program In Lowerlimb Amputees: A Randomized Controlled Study, Bahar Anaforoğlu, Fati̇h Erbahçeci̇, Mehmet Atif Erol Akseki̇li̇
The Effectiveness Of A Back School Program In Lowerlimb Amputees: A Randomized Controlled Study, Bahar Anaforoğlu, Fati̇h Erbahçeci̇, Mehmet Atif Erol Akseki̇li̇
Turkish Journal of Medical Sciences
Background/aim: A few studies have been carried out in lower limb amputees (LLAs) and they examined the incidence of and reasons for low back pain. The aim of this study was to assess the effectiveness of a back school program in LLAs with mechanical low back pain (MLBP). Materials and methods: Forty male unilateral transfemoral amputees with MLBP were randomly allocated into two groups. A back school program was applied to Group 1 over 2 weeks. A booklet for home use was given to each participant in Group 2. Pain was assessed using a visual analogue scale. Spinal flexibility measurements …
N-Terminal-Pro Brain Natriuretic Peptide Levels In Children With Allergic Rhinitis, Hasi̇be Artaç, Hüsametti̇n Vatansev, Derya Çi̇men, Derya Arslan, Fatma Kaya, Seyi̇t Ali̇ Kayiş, Bülent Oran
N-Terminal-Pro Brain Natriuretic Peptide Levels In Children With Allergic Rhinitis, Hasi̇be Artaç, Hüsametti̇n Vatansev, Derya Çi̇men, Derya Arslan, Fatma Kaya, Seyi̇t Ali̇ Kayiş, Bülent Oran
Turkish Journal of Medical Sciences
Background/aim: Persistent upper airway obstruction may lead to increased pulmonary arterial pressure (PAP). The aim of this study was to evaluate N-terminal pro brain natriuretic peptide (NT-proBNP) concentrations and PAP values in children with allergic rhinitis. Materials and methods: Sixty-six patients with allergic rhinitis and 22 healthy children were prospectively enrolled in this study. Plasma NT-proBNP levels were measured at first admission and after treatment. Simultaneously, echocardiography was done to assess pulmonary arterial hypertension, and rhinitis symptom scores were recorded. Results: The median age of the study group was 9.0 (5.0?17.0) years; 26 were female. PAP was found to be …
Ilp-2 Modeling And Virtual Screening Of An Fda-Approved Library:A Possible Anticancer Therapy, Saeed Khalili, Hemn Mohammadpour, Mahideh Shokrollahi Barough, Parviz Kokhaei
Ilp-2 Modeling And Virtual Screening Of An Fda-Approved Library:A Possible Anticancer Therapy, Saeed Khalili, Hemn Mohammadpour, Mahideh Shokrollahi Barough, Parviz Kokhaei
Turkish Journal of Medical Sciences
Background/aim: The members of the inhibitors of apoptosis protein (IAP) family inhibit diverse components of the caspase signaling pathway, notably caspase 3, 7, and 9. ILP-2 (BIRC-8) is the most recently identified member of the IAPs, mainly interacting with caspase 9. This interaction would eventually lead to death resistance in the case of cancerous cells. Therefore, structural modeling of ILP-2 and finding applicable inhibitors of its interaction with caspase 9 are a compelling challenge. Materials and methods: Three main protein modeling approaches along with various model refinement measures were harnessed to achieve a reliable 3D model, using state-of-the-art software. Thereafter, …
Higher Neutrophil To Lymphocyte Ratio Is Related To A Lower Ejectionfraction In Bicuspid Aortic Valve Patients, Haci Ahmet Kasapkara, Abdullah Nabi̇ Aslan, Hüseyi̇n Ayhan, Murat Can Güney, Murat Akçay, Zeynep Şeyma Turi̇nay, Tahi̇r Durmaz, Telat Keleş, Engi̇n Bozkurt
Higher Neutrophil To Lymphocyte Ratio Is Related To A Lower Ejectionfraction In Bicuspid Aortic Valve Patients, Haci Ahmet Kasapkara, Abdullah Nabi̇ Aslan, Hüseyi̇n Ayhan, Murat Can Güney, Murat Akçay, Zeynep Şeyma Turi̇nay, Tahi̇r Durmaz, Telat Keleş, Engi̇n Bozkurt
Turkish Journal of Medical Sciences
Background/aim: Inflammation plays an important role in the pathophysiology of vascular disease. In this study, we aimed to evaluate the associations of neutrophil to lymphocyte ratio (NLR; an indicator of inflammation) with left ventricular ejection fraction and ascending aorta diameter in patients with a bicuspid aortic valve (BAV). Materials and methods: One hundred and thirty-nine consecutive patients with the diagnosis of BAV were enrolled in the study. Complete blood counts were analyzed for neutrophil and lymphocyte levels and NLR. The subjects were separated into two groups based on their ascending aorta diameter. The patients with ascending aorta diameter equal to …
Do Patients With Neurogenic Bladder Treated With Clean Intermittentcatheterization Need Antibacterial Prophylaxis?, İpek Aki̇l, Çinar Özen, Beyhan Cengi̇z
Do Patients With Neurogenic Bladder Treated With Clean Intermittentcatheterization Need Antibacterial Prophylaxis?, İpek Aki̇l, Çinar Özen, Beyhan Cengi̇z
Turkish Journal of Medical Sciences
Background/aim: In this study, we investigated the effectiveness of antibiotic prophylaxis (ABP) with respect to the incidence of symptomatic urinary tract infections (UTIs) and evaluated the development of renal scarring in patients treated with clean intermittent catheterization (CIC). Materials and methods: A total of 22 patients were included in the study. The patients were administered ABP in the first year (the ABP-received period) but not in the second year (the ABP-discontinued period). Results: Twenty-eight of all cultures taken in the ABP-received period (18.2%) and 25 (16.2%) of the ABP-discontinued cultures were considered to be indicative of symptomatic UTIs (P = …
The Effects Of Pulmonary Hypertension On Early Outcomes Inpatients Undergoing Coronary Artery Bypass Surgery, Bariş Akça, Köksal Dönmez, Olcay Murat Di̇şli̇, Feray Akgül Erdi̇l, Mehmet Cengi̇z Çolak, İlhan Koray Aydemi̇r, Bektaş Battaloğlu, Nevzat Erdi̇l
The Effects Of Pulmonary Hypertension On Early Outcomes Inpatients Undergoing Coronary Artery Bypass Surgery, Bariş Akça, Köksal Dönmez, Olcay Murat Di̇şli̇, Feray Akgül Erdi̇l, Mehmet Cengi̇z Çolak, İlhan Koray Aydemi̇r, Bektaş Battaloğlu, Nevzat Erdi̇l
Turkish Journal of Medical Sciences
Background/aim: To investigate the effects of pulmonary hypertension on early clinical variables in patients undergoing coronary artery bypass grafting surgery. Materials and methods: The preoperative echocardiographic data of patients who underwent isolated coronary artery bypass surgery were evaluated retrospectively. A total of 1244 patients were included in the study. The patients were divided into two groups: one group consisted of patients with systolic pulmonary artery pressure (SPAP) values equal to or greater than 30 mmHg (Group 1, n = 184), while the other group consisted of patients with SPAP values below 30 mmHg (Group 2, n = 1060). Results: Early …
Retracted Article: Dna Profiling In Blood, Buccal Swabs, And Hair Follicles Of Transplantation Patients, Volkan Zeybek, Yücel Arisoy
Retracted Article: Dna Profiling In Blood, Buccal Swabs, And Hair Follicles Of Transplantation Patients, Volkan Zeybek, Yücel Arisoy
Turkish Journal of Medical Sciences
No abstract provided.
Correlation Of Ki-67 Proliferation Index And 18-Fluorodeoxyglucose Uptake In Colorectal Incidental Lesions Detected By Positron Emission Tomography-Computed Tomography, Servet Güreşci̇, Özlem Özmen, Meti̇n Uzman, Gülçi̇n Şi̇mşek, Ebru Tatci, Ati̇la Gökçek, Abdullah Özgür Yeni̇ova
Correlation Of Ki-67 Proliferation Index And 18-Fluorodeoxyglucose Uptake In Colorectal Incidental Lesions Detected By Positron Emission Tomography-Computed Tomography, Servet Güreşci̇, Özlem Özmen, Meti̇n Uzman, Gülçi̇n Şi̇mşek, Ebru Tatci, Ati̇la Gökçek, Abdullah Özgür Yeni̇ova
Turkish Journal of Medical Sciences
Background/aim: To investigate whether focal high maximum standardized uptake value (SUVmax) determined by 18-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) imaging is correlated with proliferation index in the colorectal region. Materials and methods: SUVmax values of 31 colorectal neoplasms that were incidentally detected during PET-CT examination were compared to dysplasia degree, histopathologic diagnosis, and immunohistochemical expression of the Ki-67 proliferation marker. Results: Statistically significant correlations were found between SUVmax and Ki-67 proliferation index, dysplasia degree, and histopathologic diagnosis. Median SUVmax value was found to be significantly higher in high-risk lesions than low-risk lesions. Conclusion: The Ki-67 proliferation index is …