Medicine and Health Sciences Commons^™

Most Common Single-Nucleotide Polymorphisms Associated With Rheumatoid Arthritis In Persons Of European Ancestry Confer Risk Of Rheumatoid Arthritis In African Americans, Laura B. Hughes, Richard J. Reynolds, Elizabeth E. Brown, James M. Kelley, Brian Thomson, Doyt L. Conn, Beth L. Jonas, Andrew O. Westfall, Miguel A. Padilla, Leigh F. Callahan

Psychology Faculty Publications

Objective. Large-scale genetic association studies have identified >20 rheumatoid arthritis (RA) risk alleles among individuals of European ancestry. The influence of these risk alleles has not been comprehensively studied in African Americans. We therefore sought to examine whether these validated RA risk alleles are associated with RA risk in an African American population.

Methods. Twenty-seven candidate single-nucleotide polymorphisms (SNPs) were genotyped in 556 autoantibody-positive African Americans with RA and 791 healthy African American control subjects. Odds ratios (ORs) and 95% confidence intervals (95% CIs) for each SNP were compared with previously published ORs for RA patients of European ancestry. We …

An Examination Of The Association Of Selected Toxic Metals With Total And Central Obesity Indices: Nhanes 99-02, Miguel A. Padilla, Mai Elobeid, Douglas M. Ruden, David B. Allison

Psychology Faculty Publications

It is conceivable that toxic metals contribute to obesity by influencing various aspects of metabolism, such as by substituting for essential micronutrients and vital metals, or by inducing oxidative stress. Deficiency of the essential metal zinc decreases adiposity in humans and rodent models, whereas deficiencies of chromium, copper, iron, and magnesium increases adiposity. This study utilized the NHANES 99-02 data to explore the association between waist circumference and body mass index with the body burdens of selected toxic metals (barium, cadmium, cobalt, cesium, molybdenum, lead, antimony, thallium, and tungsten). Some of the associations were significant direct relationships (barium and thallium), …

Individualized Cognitive Modeling For Close-Loop Task Mitigation, Guangfan Zhang, Roger Xu, Wei Wang, Jiang Li, Tom Schnell, Mike Keller, Thomas E. Pinelli (Ed.)

Electrical & Computer Engineering Faculty Publications

An accurate real-time operator functional state assessment makes it possible to perform task management, minimize risks, and improve mission performance. In this paper, we discuss the development of an individualized operator functional state assessment model that identifies states likely leading to operational errors. To address large individual variations, we use two different approaches to build a model for each individual using its data as well as data from subjects with similar responses. If a subject's response is similar to that of the individual of interest in a specific functional state, all the training data from this subject will be used …

Adjacent Slice Prostate Cancer Prediction To Inform Maldi Imaging Biomarker Analysis, Shao-Hui Chuang, Xiaoyan Sun, Lisa Cazares, Julius Nyalwidhe, Dean Troyer, O. John Semmes, Jiang Li, Frederic D. Mckenzie, Nico Karssemeijer (Ed.), Ronald M. Summers (Ed.)

Electrical & Computer Engineering Faculty Publications

Prostate cancer is the second most common type of cancer among men in US [1]. Traditionally, prostate cancer diagnosis is made by the analysis of prostate-specific antigen (PSA) levels and histopathological images of biopsy samples under microscopes. Proteomic biomarkers can improve upon these methods. MALDI molecular spectra imaging is used to visualize protein/peptide concentrations across biopsy samples to search for biomarker candidates. Unfortunately, traditional processing methods require histopathological examination on one slice of a biopsy sample while the adjacent slice is subjected to the tissue destroying desorption and ionization processes of MALDI. The highest confidence tumor regions gained from the …

Prostate Cancer Region Prediction Using Maldi Mass Spectra, Ayyappa Vadlamudi, Shao-Hui Chuang, Xiaoyan Sun, Lisa Cazares, Julius Nyalwidhe, Dean Troyer, O. John Semmes, Jiang Li, Frederic D. Mckenzie

Electrical & Computer Engineering Faculty Publications

For the early detection of prostate cancer, the analysis of the Prostate-specific antigen (PSA) in serum is currently the most popular approach. However, previous studies show that 15% of men have prostate cancer even their PSA concentrations are low. MALDI Mass Spectrometry (MS) proves to be a better technology to discover molecular tools for early cancer detection. The molecular tools or peptides are termed as biomarkers. Using MALDI MS data from prostate tissue samples, prostate cancer biomarkers can be identified by searching for molecular or molecular combination that can differentiate cancer tissue regions from normal ones. Cancer tissue regions are …

Destruction Of Α -Synuclein Based Amyloid Fibrils By A Low Temperature Plasma Jet, Erdinc Karakas, Agatha Munyanyi, Lesley Greene, Mounir Laroussi

Electrical & Computer Engineering Faculty Publications

Amyloid fibrils are ordered beta-sheet aggregates that are associated with a number of neurodegenerative diseases such as Alzheimer and Parkinson. At present, there is no cure for these progressive and debilitating diseases. Here we report initial studies that indicate that low temperature atmospheric pressure plasma can break amyloid fibrils into smaller units in vitro. The plasma was generated by the plasma pencil, a device capable of emitting a long, low temperature plasma plume/jet. This avenue of research may facilitate the development of a plasma-based medical treatment.

Aerobic Training Increases Skin Perfusion By A Nitric Oxide Mechanism In Type 2 Diabetes, Sheri R. Colberg, Laura C. Hill, Henri K. Parson, Kathleen S. Thomas, Aaron I. Vinik

Human Movement Studies & Special Education Faculty Publications

It is well known that a number of locally released vasodilatory and vasoconstrictive compounds can affect skin perfusion. This study investigated the effects of aerobic training on the contribution of nitric oxide (NO), prostaglandins (PG), and endothelial-derived hyperpolarizing factor (EDHF) in stimulated dorsal foot skin perfusion in individuals with type 2 diabetes (T2DM). Ten previously sedentary, older individuals with T2DM (57.0 ± 3.1 years) and nine sedentary controls (53.5 ± 3.2 years) were tested before and after undertaking six months of moderate aerobic training three times weekly in a supervised setting. All subjects underwent measurement of baseline (32°C) and heat-stimulated …

Bisphenol A Blood And Saliva Levels Prior To And After Dental Sealant Placement In Adults, Joyce M. Zimmerman-Downs, Deanne Shuman, Sharon C. Stull, Robert E. Ratzlaff

Dental Hygiene Faculty Publications

Purpose: This study examined the effects of a widely used (Delton® Pit & Fissure Sealant – Light Cure Opaque, DENTSPLY Professional, York, PA) pit and fissure sealant material on bisphenol A (BPA) levels in blood and saliva, among both low and high–dose groups over time.

Methods: A convenience sample of 30 adults from the Old Dominion University population were randomly and evenly divided into 2 independent variable groups: a low–dose group (1 occlusal sealant application) and high–dose group (4 occlusal sealant applications). A 2 group, time series design was used to examine the presence and concentration of BPA in serum …

Psychosocial Correlates Of Insomnia Severity In Primary Care, Daniel Bluestein, Carolyn M. Rutledge, Amanda C. Healey

Ellmer School of Nursing Faculty Publications

Purpose: Insomnia is a substantive primary care issue that leads to adverse outcomes. These can be improved by addressing factors that accentuate insomnia severity. Accordingly, this study identifies correlates of insomnia severity and determines whether these relationships vary with sociodemographic attributes.

Methods: This correlational cross-sectional study was conducted in a hospital-sponsored primary care clinic and 2 urban, academic family practice centers. Participants consisted of 236 patients 18 years old or older with clinically significant insomnia (Insomnia Severity Index scores of 7 or more). Surveys instruments included the Insomnia Severity Index, SF-8 (Medical Outcomes Study SF-8 global health status measure), CES-D …

Comparative Validity Of Mmpi-A Scales Scores In African American And Caucasian Male Juvenile Delinquents, Stacy Natasha Wilson

Psychology Theses & Dissertations

This study examined comparative validity of the MMPI-A scale scores of African American and Caucasian male juvenile delinquents utilizing a step down hierarchical regression procedure proposed by Laughtenschlager & Mendoza (1986). The MMPI-A (Butcher et al., 1992) was administered to 281 African American and Caucasian juvenile delinquents while their caretakers filled out the CBCL (Achenbach, 1991; Achenbach & Rescorla, 2001) and DBRS (Barkley & Murphy, 1998), which were used as extra-test measures. Significant overall prediction bias was detected in 15 out of 56 regressions. Statistically significant prediction bias was found for a subset of criterion variables for Clinical Scales 2, …

Predictors Of Developmental Screenings For Young Children, Janice Chandler Ranne

Health Services Research Dissertations

This study examines the usefulness of the New Model of Children's Health and its Influences for the identification of predictors for health service effectiveness. Health service effectiveness is measured by probability estimations of whether young children receive formal or informal developmental screenings. Screenings lead to prevention of communication delays in later childhood. Formal screenings with standardized questions are preferred over informal screenings, which are knowledgeable observations. The theoretical framework is a child-centered socio-ecological theory that is untested for use in health service effectiveness studies until the present one. Four developmental concepts of the theoretical framework, social environment, physical environment, biological …

The Association Between Parental Perceptions Of Children's Residential Mental Health Treatment And The Parent-Child Relationship, Susanne Elizabeth Preston

Counseling & Human Services Theses & Dissertations

Residential mental health treatment for children as an intervention for children is increasing, potentially affecting the relationship within families. The purpose of this study was to examine the parental perspectives of the associations between the parent-child relationship and children's residential mental health treatment. This study explored parental perspectives of specific aspects of the parent-child relationship: parental support, satisfaction with parenting, parental involvement, communication, and limit setting-and the association between these aspects and the child's residential mental health treatment. Paired samples t-tests were conducted; resulting in statistically significant changes on all scales measured, with varying effect sizes. Results indicated parents …

Mindfulness Meditation And Art Making: Implications For Art Therapy, Susan Kathleen Mahl

EVMS School of Health Professions Theses & Dissertations

Meditation is being integrated into various fields to aid with healing, especially mindfulness meditation as it focuses on total awareness of the present. This thesis describes a self study that used a heuristic methodology to investigate the effects of mindfulness meditation on this researcher. I progressed through the six phases of heuristic research in a period seven weeks. At the beginning of the study, mindfulness meditation was practiced twice a week for a time period of 30 minutes to one hour for three weeks, followed by art making and reflections. Next, I practiced mindfulness meditation three times a week for …

Ekg Tracking For Augmented Standardized Patient Virtual Pathology Stethoscope Heart Auscultation, Sujith Surendran

Electrical & Computer Engineering Theses & Dissertations

In recent years, a lot of research has focused on improving the clinical skills of medical students and medical practitioners using standardized patients. Standardized patients (SP's) are used by the medical students and physicians in place of mannequins for a more realistic experience. SP's are real people trained to simulate specific illnesses and conditions to a high degree of accuracy which makes it difficult for the medical students to distinguish them from real patients. This research will enhance the capabilities of the standardized patients by providing a non-invasive, natural, harmless and realistic appearing tracking method for placing virtual pathologies using …

Bactericidal Effects Of Low Temperature Atmospheric Pressure Plasma On Porphyromonas Gingivalis, Arwa Mahasneh

Dental Hygiene Theses & Dissertations

Purpose: The biomedical application of low temperature atmospheric pressure plasma (LTAPP) is a collaborative interest for engineering, medical, dental and biological researchers. This laboratory study tested whether LTAPP can limit growth of Porphyromonas gingivalis, a periodontal pathogen strongly associated with periodontal disease, disease progression, and refractory periodontitis. Methods: After extensive pilot trials, the study consisted of 24 agar plate samples of P. gingivalis- 20 samples were exposed to LTAPP at 5, 7, 9 and 10 minutes and 4 control samples were exposed to helium gas only. Immediately after exposures, the samples were incubated anaerobically for 72 hour at …

The Role Of Human Endogenous Retroviruses In Renal Cell Carcinoma, Michele D. Tisdale

Biological Sciences Theses & Dissertations

Human endogenous retroviruses make up approximately 8-9% of the human genome. A number of expressed HERVs, those that are actively transcribing, have been associated with various cancers. Suppression mechanisms that control HERV expression often fail or become more permissive in tissues where expression should be restricted. Previous studies have identified HERV expression in breast cancer tissues, whereas normal tissue HERV expression remained suppressed. In addition, studies of DNA hypermethylation have correlated with the ability to contribute to cancer development. Hypermethylation of several tumor suppressor genes occurs frequently in cancers and alterations in promoter regions could contribute to the development of …

Effects Of Non-Equilibrium Plasma On Eukaryotic Cells (Final Report: Grant Fa9550-06-1-0004), Mounir Laroussi, Fred C. Dobbs, Old Dominion University

Electrical & Computer Engineering Faculty Publications

This document is our final report describing the research activities carried out under AFOSR Grant FA9550-06-1-0004. First, descriptions of our cold plasma generation systems are presented. Two systems, developed with past and present AFOSR support, are available in our laboratory. The first is a pulsed device capable of emitting a cold plasma plume in room air. The second is an air plasma generator the core of which is a dielectric barrier discharge excited by a high AC voltage. Following these brief descriptions we first present the effects of an atmospheric pressure air plasma on four different types of eukaryotic microalgae. …

Brain Tumor Progression Assessment Using Multiple Mri Volumes, Yufei Shen

Electrical & Computer Engineering Theses & Dissertations

Predicting and assessing tumor progression is important in brain tumor treatment. We attempt to use machine learning techniques to achieve consistency in assessing brain tumor progression. This thesis presents a prediction method of brain tumor progression by exploring a large MR database, which contains two patients ' complete records covering all their visits in the past two years. All ten MRI series, namely, apparent diffusion coefficient (ADC) , diffusion tensor imaging (DTI) , fractional anisotropy (FA), fluid attenuated inversion recovery (FLAIR), max eigenvalue (MAX), mid eigenvalue (MID), min eigenvalue (MIN) , post-contrast T₁-weighted, T₁- weighted, and …

Effects Of Low-Temperature Atmospheric Pressure Plasma On Streptococcus Mutans, Margaret Farrer Lemaster

Dental Hygiene Theses & Dissertations

The recent emergence of low temperature atmospheric pressure plasma (LTAPP) technology has led researchers to explore biomedical applications. The present study set out to determine if LTAPP has the ability to inactivate dental caries causing bacteria, specifically Streptococcus mutans. Methods: A total of 90 samples were processed. Seventy-two samples of S. mutans at 1: 100 dilution in BHI broth were exposed to LTAPP for various time intervals (60, 120, 180, 300 seconds). Eighteen control samples were plated but not exposed to LTAPP. Samples were plated on Mi tis salivarius (MS) agar and incubated 48 hours at 37° C. Colony …

Inhibition Of Yeast Hexokinase By The Antimalarial Drug Artemisinin: Probing Mechanism Of Action With A Model Enzyme, Jennifer S. Spence

Biological Sciences Theses & Dissertations

A leading infectious cause of death, malaria threatens approximately half of the world's population, and drug-resistant strains of Plasmodium falciparum have created immense difficulty in chemotherapy of the disease. The artemisinin (ART) class of antimalarials may represent a powerful solution. In addition to their safety, effectiveness, and moderate cost, they are the only drugs in use for which there has been no widespread evidence of clinical resistance. The exact parasiticidal mechanism of ART is highly contested, but evidence suggests that protein alkylation may play a role in cytotoxicity. in vitro essays were performed using yeast hexokinase (HK) to demonstrate a …

Section Abstracts: Medical Sciences

Virginia Journal of Science

Abstracts of the Medical Science Section for the 87th Annual Meeting of the Virginia Academy of Science, May 27-29, 2009, Virginia Commonwealth University, Richmond, Virginia.

Adjacent Slice Prostate Cancer Prediction To Inform Maldi Imaging Biomarker Analysis, Shao-Hui Chuang

Electrical & Computer Engineering Theses & Dissertations

Prostate cancer is the second most common type of cancer among men in the U.S. [1]. Traditionally, prostate cancer diagnosis is made by the analysis of prostate-specific antigen (PSA) levels and histopathological images of biopsy samples under microscopes. Proteomic biomarkers can improve upon these methods. MALDI molecular spectra imaging is used to visualize protein/peptide concentrations across biopsy samples to search for biomarker candidates. Unfortunately, traditional processing methods require histopathological examination on one slice of a biopsy sample while the adjacent slice is subjected to the tissue destroying desorption and ionization processes of MALDI. The highest confidence tumor regions gained from …

Using Art Therapy To Increase Self-Efficacy Beliefs Of Homeless Mothers Living In A Shelter, Mandi Elizabeth Wines

EVMS School of Health Professions Theses & Dissertations

Literature reveals that homelessness is inherently a situation where desired outcomes are less likely than unfavorable outcomes, and, as such, the concepts of learned hopelessness, disempowerment, and low self-efficacy are especially relevant. Self-efficacy has been found to affect one’s motivation, performance, coping, self-esteem, emotional arousal, and behavior. Homeless women who possess a stronger sense of self-efficacy are more likely to actively engage in employment and housing searches and spend less time in temporary shelters than those with low self-efficacy.

Although aspects of this problem have been studied no specific intervention models have proven effective in increasing homeless women’s self-efficacy. Literature …

An Art Therapy Approach To Addressing Burnout Prevention Among Pediatric Healthcare Providers, Hoilam Tang

EVMS School of Health Professions Theses & Dissertations

The purpose of this thesis was to develop an art therapy based burnout prevention program for pediatric healthcare providers who work directly with chronically and/or terminally ill children. This program will run for a period of four months. Eight sessions were designed to implement self-care skills, promote a supportive working environment and professional boundaries, address grief and loss, and process work-related stress and distress in order to reduce burnout and compassion fatigue among pediatric healthcare providers. This program was designed for 5 to 7 healthcare providers who have similar experiences and work duties. This program will run as a peer …

The Chakra Energy System And Art Therapy: A Heuristic Study, Linda Scalise

EVMS School of Health Professions Theses & Dissertations

The chakra system, an Eastern philosophy relating to an individual’s health, energy, and consciousness, has been integrated into the healing practices of psychology, meditation, yoga, and alternative medicine. Dale (2005), Judith (1996), and Myss (1996) described the chakra energy system as focal points embedded within the human energy system that regulate all components of the self. Researchers in complementary therapies and energy medicine have long been interested in how the integration of this system affects the progression of disease, human behavior, and emotional disturbances. However, although rich in symbolism and metaphor, no literature has been found demonstrating the use of …

Life Drawing With Gross Anatomy Medical Students And Implications For Art Therapy, Elliott Addesso

EVMS School of Health Professions Theses & Dissertations

It is important to incorporate humanities training into medical education in order to enhance the potential for humane and ethical interactions among physicians. In this study, a life drawing studio course was led by an art therapy graduate student to explore the effects of a life drawing course on medical students concurrently enrolled in Gross Anatomy. Based on students’ perceptions of their experience in the life drawing class, theoretical implications for the practice of art therapy in studio applications were discussed.

Five medical students participated in the course on a voluntary, non-credit basis. The course consisted of seven meetings and …

Exploring American Indian Adolescents’ Needs Through A Community-Driven Study, Emily Gordon Basto

EVMS School of Health Professions Theses & Dissertations

The current higher rates of substance use and abuse for Native American adolescents compared to non-Natives is an issue that requires attention. There are a variety of risk factors that lead to this current situation, including discrimination and acculturation pressures. Past treatment options have been limited with American Indians and have not incorporated community involvement. Art therapy has been utilized in substance abuse programs and with American Indian populations; however, art therapy has been limited in taking a community-driven approach. As art therapy and community involvement are seen as culturally relevant, together they may serve as a model for assessing …

The Application Of Art Therapy Techniques To The Resolution Of Conflict, Maggie Hart

EVMS School of Health Professions Theses & Dissertations

Conflict is present in innumerable forms in current society. As a result, a variety of methods of conflict resolution exist, both constructive and destructive. The prevalence of conflict in our everyday lives warrants further study about improved means of resolution. Art therapy theory and techniques have much to offer the process of conflict resolution. Currently, a body of research about using art to explore past or future conflicts does exist. However, this literature lacks a thorough examination of using art in order to process and resolve current conflicts, involving all parties involved in the conflict.

The current study explores the …

Attachment Styles And Children In Foster Care: A Study Involving Art Therapy Evaluation, Abigail Johnson

EVMS School of Health Professions Theses & Dissertations

This case study explored the attachment style and perceptions of family, from the perspective of children in the foster care system, through the use of art therapy evaluative methods. The participants for this study included two half-sisters in the second and fourth grades. The Art Therapy-Projective Imagery Assessment (AT-PIA) was adapted and used to construct a well-rounded understanding of each client. Within the adapted AT-PIA, the Human Figure Drawing and the Bird’s Nest Drawing were evaluated using rating schemes. A dyad session was held with the two participants, where a Safe Place Sculpture was created. Review of the artwork revealed …

Mechanisms Of Regulation Of Proximal Tubule Sodium Transporters In Obesity-Induced Hypertension, Marta A. Ambrozewicz

Theses and Dissertations in Biomedical Sciences

Hypertension is one of the common complications of obesity. Using a rat model of diet induced obesity and hypertension we investigated some of the mechanisms that are involved in regulation of blood pressure in obesity. The first aim of this study was to determine the role of proximal tubule transporters on the renal sodium handling in obese hypertensive (OP) and lean normotensive (OR) rats. An acute increase in renal perfusion pressure resulted in a blunted natriuretic response in OP vs. OR rats and indicated that increased sodium reabsorption in the proximal tubule is casual, at least in part, for hypertension …