Medicine and Health Sciences Commons^™

Section Abstracts: Medical Science

Virginia Journal of Science

Abstracts of the Medical Sciences Section for the 88th Annual Meeting of the Virginia Academy of Science, May 20-21, 2010, James Madison University, Harrisonburg, Virginia.

A Gis Analysis Of The Environmental Variables Related To Rift Valley Fever Outbreaks, Jacqueline Florette Jackson

Health Services Research Dissertations

Rift Valley fever is a mosquito-borne disease that causes widespread febrile illness and mortality in domestic animals as well as humans (Gaff, 2007). Rift Valley fever virus was first isolated in 1931 (Daubney, 1931), and since then, outbreaks have occurred in sub-Saharan Africa, southern Africa, Egypt, Saudi Arabia, Yemen and Madagascar, proving it to be a virus able to invade ecologically diverse regions (Gaff, 2007). The potential introduction of Rift Valley fever into the United States suggests the potential for human infection and major economic disruption. It is important to understand the role environmental variables have played in historical outbreaks …

Patient Centered Care Approach To Adherence With Cardiovascular Medications: Self-Determination Theory Integration, David S. Li

Health Services Research Dissertations

Problem statement. Behavioral intervention is used to improve adherence with medication in patients with cardiovascular diseases (CVD), but the effect was not sustainable. Patient-centered care (PCC) as a consumer movement has gained acceptance, but it lacks a theoretical framework. Self-determination theory (SDT) may provide an alternative to improve patients' adherence to chronic cardiovascular medication, as well as a theoretical framework for PCC. Both approaches to CVD management have not been evaluated.

Methods. The study was a quasi-experimental pretest posttest comparison design with consecutive sampling of a hospitalized cardiac patient population. Sixty patients each for the usual care (UC) …

Neuromechanical Analysis Of Anterior Cruciate Ligament Risk Factors In Female Collegiate Soccer Athletes, Nelson Cortes

Human Movement Studies & Special Education Theses & Dissertations

The anterior cruciate ligament (ACL) acts in an essential role to prevent anterior tibial displacement when experiencing jump-landing forces that are applied to the lower extremity; more than 100,000 injuries per year in the United States in sport activities that often require landing, deceleration-acceleration, cutting and pivoting actions have been reported. The aim of this study was to examine the nature of any lower limb coupling differences between a drop-jump and a side-step cutting actions, assess kinematic and kinetic differences between three tasks, and evaluate the effects of two landing techniques in biomechanical risk factors while performing two unanticipated tasks. …

The Correlation Between Visual Observations And Inclinometric Measurements For Special Tests Related To Patellofemoral Pain Syndrome, Erin Quada

Human Movement Studies & Special Education Theses & Dissertations

Patellofemoral pain syndrome (PFPS) is generally described as an insidious onset with pain increasing during running, jumping, ascending and descending stairs as well as sitting with the knees flexed for an extended period of time. Clinicians often use special tests in injury evaluations and range of motion assessments, usually making a visual observation of that status of the patient. The purpose of this study was to examine how interval measurements utilized in flexibility and range of motion assessments correlate with visual observations of special tests (active knee extension test, Thomas test, Ober's test, rectus femoris flexibility, and Craig's test). The …

The Effectiveness Of Counselors As Care Managers In Improving Self-Management And Medical Outcomes In Persons With Poorly Controlled Diabetes, Ularisi Rebecca Green

Counseling & Human Services Theses & Dissertations

This study investigated whether providing counselors as care managers to individuals who were having difficulty managing their Type II diabetes improved their self-management, health, and functioning. Counselors used the Motivational Interviewing Model and met weekly over a six month period with patients who had Type II diabetes who had been identified as not functioning well in managing their disease. The success of the intervention was determined by a number of measures including physical symptoms of patients; patients' perceptions of the care they received; and patients' self-efficacy in managing their diabetes. The results of this study suggested that providing counselors as …

The Effects Of An Anterior Cruciate Ligament Prevention Program And Retention Period On Lower Extremity Biomechanics, Ryan S. Mccann

Human Movement Studies & Special Education Theses & Dissertations

Researchers have attempted to determine the effects of strength, flexibility, agility, and plyometric training, as well as expert feedback on biomechanical risk factors for anterior cruciate ligament (ACL) injuries. Currently, the literature lacks information regarding athletes' ability to retain adaptations made during programs designed to reduce biomechanical risk factors for ACL injuries. The purpose of this study was to determine the effects of a 10-week strength and agility program on lower extremity kinetics and kinematics of collegiate athletes immediately following training and after a 11-week retention period. Ten NCAA Division I female soccer players free of lower extremity injury, volunteered …

The Effects Of Cocaine And Ecstasy On Cardiac Myocytes And The Intact Myocardium, David A. Tiangco

Theses and Dissertations in Biomedical Sciences

Cocaine and ecstasy are widely used illicit drugs. Both drugs have undergone intense scrutiny as information regarding their side-effects has become available. One important yet incomplete area of investigation pertains to their effects on the heart. The purpose of the current studies was to test the hypothesis that exposure to cocaine or ecstasy will adversely affect cellular homeostasis and normal heart function. Cultured cardiac myocytes (H9c2) and New Zealand White rabbits (Oryctolagus cuniculus) were used to measure the responses to various concentrations of cocaine or ecstasy at both the cellular and intact organ system levels. We observed that cocaine and …

Art Therapy Support Group For Siblings Of Children With Autism, Christine Mccann Giardina

EVMS School of Health Professions Theses & Dissertations

Siblings of children with autism are at an increased risk for psychosocial and adjustment difficulties due to the extra stresses and frustrations they often experience. This qualitative, phenomenological multiple case study explored the unique experiences of siblings of children with autism in an art therapy support group. Seven 40 minute art therapy sessions, occurring approximately once per month, were implemented to address the specific concerns of siblings of children with autism. This study included three participants who agreed to share their experiences and their reactions to the sibling art therapy support group. Case reports were generated from session observations, semi-structured …

Climate Change And Sea Level Rise Initiative (Ccslri), Larry P. Atkinson

CCSLRI Brochures

Brochure of the Old Dominion University Climate Change and Sea Level Rise Initiative (CCSLRI)

Increasing The Use Of Booster Seats: A Community-Based Research Project, Michelle Gallina, Amanda Jones, Jane Kim, Habibullah Muhiddin, Natasha Singletary

OUR Journal: ODU Undergraduate Research Journal

The aim of this project was to increase booster seat usage and knowledge of booster seat safety by implementing population-based interventions in the community. To aid in accomplishing the goal, the nursing students utilized the performance of an educational puppet show, educational handouts, and aggregate height and age screening as the interventions. Pre and post tests data were obtained. As a result, there was an increase of the aggregates‟ desire to be in a booster seat. Nurses who take more action in a leadership role by implementing interventions based on the educational needs of the community increased booster seat awareness. …

Childhood Home Injuries: A Nursing Student Approach To Preventing Childhood Home Injuries, Jinging Sparrow, Katherine Carman, Katelyn Kerr, Renee Farmer

OUR Journal: ODU Undergraduate Research Journal

Unintentional injuries are the leading cause of death for children under 14 years of age. Of the unintentional injuries, a significant portion occurs within the home setting. Creating a safe home environment for children has become a focus in current efforts for health promotion and injury prevention. Our objective is to enhance caregivers’ knowledge of home safety thus decreasing the incidence of childhood unintentional injuries. To this end, a series of educational workshops were conducted on poisoning, choking, furniture tip-over, scalds and burns. The material was presented via PowerPoint, videos, posters, handouts, demonstrations and return demonstrations. Verbal pre-and post tests …

A Benefits-Based Study Of Appalachian Trail Users: Validation And Application Of The Benefits Of Hiking Scale, Barbara Freidt, Eddie Hill, Edwin Gomez, Marni Goldenberg

Human Movement Studies & Special Education Faculty Publications

Lack of exercise has been linked to poor health issues (e.g., obesity) in American society. National (e.g., Appalachian Trail) and local trails are a potential resource for championing physical activity. To challenge sedentary lifestyle choices and promote more active ones, an understanding of the benefits perceived to be associated with physical and outdoor activities is needed. A total of 454 Appalachian Trail user surveys were collected. Validity analyses and reliability analyses showed the Benefits of Hiking Scale to be an accurate and consistent measure of the dimensions of recreation benefits. Within the improved condition dimension of Benefits, significant differences were …

Effects Of Training On Physical Performance Wearing Personal Protective Equipment, David P. Swain, James A. Onate, Stacie I. Ringleb, Dayanand N. Naik, Marlene Demaio

Human Movement Studies & Special Education Faculty Publications

We evaluated the effects of wearing a weighted vest during 6 weeks of military-style training. Forty-three subjects were randomly assigned to a control group or a vest group (carrying 4-5 kg for 2 weeks, and 8-10 kg for 4 weeks), with 37 completing the study (17 vest, 20 control). Both groups performed stair climbing in addition to standard Marine Corps training for 1 hour, four times per week. Pre- and post-tests were performed while wearing military personal protective equipment, with the exception of the Marine Physical Readiness Test (PRT). Both groups significantly improved PRT scores (8.4% 3-mile run, 28-38% calisthenics) …

Exercise And Type 2 Diabetes: The American College Of Sports Medicine And The American Diabetes Association: Joint Position Statement, Sheri R. Colberg, Ronald J. Sigal, Bo Fernhall, Judith G. Regensteiner, Bryan J. Blissmer, Richard R. Rubin, Lisa Chasen-Taber, Ann L. Albrigjht, Barry Braun

Human Movement Studies & Special Education Faculty Publications

Although physical activity (PA) is a key element in the prevention and management of type 2 diabetes, many with this chronic disease do not become or remain regularly active. High-quality studies establishing the importance of exercise and fitness in diabetes were lacking until recently, but it is now well established that participation in regular PA improves blood glucose control and can prevent or delay type 2 diabetes, along with positively affecting lipids, blood pressure, cardiovascular events, mortality, and quality of life. Structured interventions combining PA and modest weight loss have been shown to lower type 2 diabetes risk by up …

Variable Number Of Tandem Repeat Polymorphisms (Vntrs) In The Acan Gene Associated With Pectus Excavatum, Michael W. Stacey, Serina Neumann, Ashley Dooley, Kara Segna, Robert Kelly, Donald Nuss, Anne Kuhn, Michael Goretsky, Annie Fecteau, Aimee Pastor, Virginia Proud

Bioelectrics Publications

No abstract provided.

Plasmid Injection And Application Of Electric Pulses Alter Endogenous Mrna And Protein Expression In B16.F10 Mouse Melanomas, L. C. Heller, Y. L. Cruz, B. Ferraro, H. Yang, R. Heller

Bioelectrics Publications

The application of electric pulses to tissues causes cell membrane destabilization, allowing exogenous molecules to enter the cells. This delivery technique can be used for plasmid gene therapy. Reporter gene expression after plasmid delivery with eight representative published protocols was compared in B16.F10 mouse melanoma tumors. This expression varied significantly based on the pulse parameters utilized for delivery. To observe the possible influence of plasmid injection and/or pulse application on endogenous gene expression, levels of stress-related mRNAs 4 and 24 h after delivery were determined by PCR array. Increases in mRNA levels for several inflammatory chemokines and cytokines were observed …

Inpatient Group Psychotherapy: Predicting Attendance And Participation, Sharon E. Silverberg

Counseling & Human Services Theses & Dissertations

Inpatient group psychotherapy is one of the primary talk therapy interventions offered to patients necessitating acute psychiatric treatment. Research indicates that patients who attend and participate in group psychotherapy sessions while admitted to psychiatric hospitals have a lower rate of recidivism and are more successful in the community utilizing lower levels of psychiatric care. Unfortunately, not all patients attend group psychotherapy while admitted to a psychiatric facility and therefore do not benefit, possibly contributing to non-compliance with community-based treatment and readmissions to inpatient psychiatric institutions for stabilization and safety. This lack of participation in group psychotherapy deprives the patient the …

Apoptosis Initiation And Angiogenesis Inhibition: Melanoma Targets For Nanosecond Pulsed Electric Fields, Xinhua Chen, Juergen F. Kolb, R. James Swanson, Karl H. Schoenbach, Stephen J. Beebe

Bioelectrics Publications

Many effective anti-cancer strategies target apoptosis and angiogenesis mechanisms. Applications of non-ionizing, nanosecond pulsed electric fields (nsPEFs) induce apoptosis in vitro and eliminate cancer in vivo; however in vivo mechanisms require closer analysis. These studies investigate nsPEF-induced apoptosis and anti-angiogenesis examined by fluorescent microscopy, immunoblots, and morphology. Six hours after treatment with one hundred 300 ns pulses at 40 kV/cm, cells transiently expressed active caspases indicating that caspase-mediated mechanisms. Three hours after treatment transient peaks in Histone 2AX phosphorylation coincided with terminal deoxynucleotidyl transferase dUTP nick end labeling positive cells and pyknotic nuclei, suggesting caspase-independent mechanisms on nuclei/DNA. Large …

Dr. Cezanne And The Art Of Re(Peat)Search: Competing Interests And Obligations In Clinical Research, Robyn L. Bluhm, Jocelyn Downie, Jeff Nisker

Philosophy Faculty Publications

Clinician researchers have a number of roles, each of which carries specific obligations. There are times when these obligations may be in competition (up to and including conflict) with each other. Using a narrative case study that describes a group of colleagues discussing their clinical department's participation in an industry-sponsored research protocol, we illustrate a number of the obligations faced by clinician researchers, and discuss how competing interests and obligations can lead to ethical problems. The case study is followed by a discussion of the effect of university-industry relations on competing interests and obligations in both clinical research and the …

The Reliability Of Portable Fixed Dynamometry During Hip And Knee Strength Assessments, Roger O. Kollock Jr., James A. Onate, Bonnie Van Lunen

Rehabilitation Sciences Faculty Publications

Context: Insufficient lower extremity strength may be a risk factor for lower extremity injuries such as noncontact anterior cruciate ligament tears. Therefore, clinicians need reliable instruments to assess strength deficiencies.

Objective: To assess the intrarater, interrater, intrasession, and intersession reliability of a portable fixed dynamometer in measuring the strength of the hip and knee musculature.

Design: Crossover study.

Setting: Sports medicine research laboratory.

Patients or Other Participants: Three raters (A, B, C) participated in this 2-phase study. Raters A and B tested 11 healthy college graduate students (2 men, 9 women) in phase 1. Raters A and C tested 26 …

Balance Training Reduces Falls Risk In Older Individuals With Type 2 Diabetes, Steven Morrison, Sheri R. Colberg, Mita Mariano, Henri K. Parson, Arthur I. Vinik

Rehabilitation Sciences Faculty Publications

OBJECTIVE - This study assessed the effects of balance/strength training on falls risk and posture in older individuals with type 2 diabetes.

RESEARCH DESIGN AND METHODS - Sixteen individuals with type 2 diabetes and 21 age-matched control subjects (aged 50-75 years) participated. Postural stability and falls risk was assessed before and after a 6-week exercise program.

RESULTS - Diabetic individuals had significantly higher falls risk score compared with control subjects. The diabetic group also exhibited evidence of mild-to-moderate neuropathy, slower reaction times, and increased postural sway. Following exercise, the diabetic group showed significant improvements in leg strength, faster reaction times, …

Prospective Associations Of Insomnia Markers And Symptoms With Depression, Mariana Szklo-Coxe, Terry Young, Paul E. Peppard, Laurel A. Finn, Ruth M. Benca

Community & Environmental Health Faculty Publications

Whether insomnia, a known correlate of depression, predicts depression longitudinally warrants elucidation. The authors examined 555 Wisconsin Sleep Cohort Study participants aged 33-71 years without baseline depression or antidepressant use who completed baseline and follow-up overnight polysomnography and had complete questionnaire-based data on insomnia and depression for 1998-2006. Using Poisson regression, they estimated relative risks for depression (Zung scale score >= 50) at 4-year (average) follow-up according to baseline insomnia symptoms and polysomnographic markers. Twenty-six participants (4.7%) developed depression by follow-up. Having 3-4 insomnia symptoms versus none predicted depression risk (age-, sex-, and comorbidity-adjusted relative risk (RR) = 3.2, 95% …

Robustness Of The Healthcare Utilization Results From The Rotavirus Efficacy And Safety Trial (Rest) Evaluating The Human-Bovine (Wc3) Reassortant Pentavalent Rotavirus Vaccine (Rv5), Robbin Itzler, Gary Koch, David O. Matson, Leif Gothefors, Pierre Van Damme, Mark J. Dinubile, Penny M. Heaton

Community & Environmental Health Faculty Publications

Background: The Rotavirus Efficacy and Safety Trial was a placebo-controlled Phase III study that evaluated the safety and efficacy of a three-dose pentavalent rotavirus vaccine (RV5) including its effect on healthcare utilization for rotavirus gastroenteritis (RVGE). The per-protocol (PP) analyses, which counted events occurring 14 days after dose 3 among infants without protocol violations, have already been published. This paper evaluates the consistency of the healthcare utilization results based on the modified intention to treat (MITT) analyses with the PP analyses. The MITT analyses include all infants receiving at least one dose of vaccine or placebo and follow-up begins after …

Sleep Well To Stay Safe: Ready For Primetime?, Mihai C. Teodorescu, Mariana Szklo-Coxe

Community & Environmental Health Faculty Publications

Commentary on Kling et al. Sleep problems and workplace injuries in Canada. Sleep 2010;33:611-618.

Maternal Employment And Childhood Obesity Among Immigrant Families, Qi Zhang

Community & Environmental Health Faculty Publications

There are continued interests to examine the relationship between maternal employment and childhood obesity. However, little research has been focused on childhood obesity among immigrant families with working mothers. This study used the Panel Survey of Income Dynamics (PSID) and Child Development Supplement (CDS) in 2002 and compared the impact of maternal employment on childhood obesity between immigrant families and US-born families. The positive effect of maternal employment on children’s body weight status was much stronger in immigrant families than in US-born families. The full-time employment status of mothers had strong and significant effect on immigrant children’s BMI (beta = …

The Effect Of Culture On Urinary Incontinence: Do We Really Understand?, Karen A. Karlowicz

Ellmer School of Nursing Faculty Publications

No abstract provided.

Using The Andersen Behavioral Model Of Health Services Use To Examine Adult Uninsured Patient Health Services Use At A Community Health Center, Jewel Shonette Goodman

Health Services Research Dissertations

Prescription medications are essential to the treatment and management of chronic conditions (Smith et al., 2005). Lack of access can result in pain, worsening of the condition and increased risk of additional health problems. Health care expenditures in the United States were reportedly 1.7 trillion in 2003 (Smithetal.,2005) and exceeded" role="presentation" style="box-sizing: border-box; display: inline-table; line-height: 0; font-size: 16.66px; overflow-wrap: normal; word-spacing: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; margin: 0px; padding: 1px 0px; position: relative;">1.7trillionin2003(Smithetal.,2005)andexceeded1.7trillionin2003(Smithetal.,2005)andexceeded2.3 trillion in 2008 (Centers for Medicare and Medicaid Services, 2010). Prescription medication costs …

Prediction Of Brain Tumor Progression Using A Machine Learning Technique, Yuzhong Shen, Debrup Banerjee, Jiang Li, Adam Chandler, Yufei Shen, Frederic D. Mckenzie, Jihong Wang, Nico Karssemeijer (Ed.), Ronald M. Summers (Ed.)

Electrical & Computer Engineering Faculty Publications

A machine learning technique is presented for assessing brain tumor progression by exploring six patients' complete MRI records scanned during their visits in the past two years. There are ten MRI series, including diffusion tensor image (DTI), for each visit. After registering all series to the corresponding DTI scan at the first visit, annotated normal and tumor regions were overlaid. Intensity value of each pixel inside the annotated regions were then extracted across all of the ten MRI series to compose a 10 dimensional vector. Each feature vector falls into one of three categories:normal, tumor, and normal but progressed to …

Bioelectric Applications For Treatment Of Melanoma, Stephen J. Beebe, Karl H. Schoenbach, Richard Heller

Bioelectrics Publications

Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs). EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in …