Medicine and Health Sciences Commons^™

Dietary Supplements And Sports Performance: Metabolites, Constituents, And Extracts, Melvin H. Williams

Human Movement Sciences & Special Education Faculty Publications

This is the fifth in a series of six articles to discuss the major classes of dietary supplements ( vitamins; minerals; amino acids; herbs or botanicals; and metabolites/constituents/extracts). The major focus is on efficacy of such dietary supplements to enhance exercise or sports performance.

2004 Jeffress Research Grant Awards

Virginia Journal of Science

List of winners of the 2004 Jeffress Research Grant Awards.

Characterization Of Β-Lactam Resistant Pandemic Serotypes Of Vibrio Cholerae Isolated From Ships' Ballast Tanks And Coastal Waters, Amanda Lynn Goodrich

OES Theses and Dissertations

Vibrio cholerae serotypes 01 and 0139 are responsible for world-wide epidemics of cholera. These pandemic causing strains must possess genes that encode for the cholera toxin (CTX) and toxin co-regulated pili (TCP) in order to infect their hosts. In this study, 284 isolates of Vibrio cholerae from ballast and coastal waters were serotyped, with 11 % testing positive for serotype 01 and 21 % testing positive for serotype 0139. PCR assays were used to detect the presence of ctxA and tcpA genes in all positive isolates, none of which contained ctxA while 2% of the isolates contained tcpA. The 01 …

Detection Of Panulirus Argus Virus 1 (Pav1) In The Caribbean Spiny Lobster Using Fluorescence In Situ Hybridization (Fish), Caiwen Li, Jeffrey D. Shields, Hamish J. Small, Kimberly S. Reece, Carmony L. Hartwig, Roland A. Cooper, Robert E. Ratzlaff

Biological Sciences Faculty Publications

Panulirus argus Virus 1 (PaV1) is the first virus known to be pathogenic to a wild lobster. It infects the Caribbean spiny lobster P. argus from the Florida Keys, and has a predilection for juveniles. The monitoring of the virus in wild populations and study of its behavior in the laboratory require the development of reliable diagnostic tools. A sensitive and specific fluorescence in situ hybridization (FISH) assay was developed for detection of PaV1. The lower detection limit using a 110 bp DNA probe in a dot-blot hybridization for PaV1 DNA was 10 pg of cloned template PaV1 DNA and …

Vital Tooth Whitening: Effects On Tooth Color Satisfaction, Beliefs About Dentofacial Appearance, And Self-Esteem In Older Adults, Kelly Marie Seeber

Dental Hygiene Theses & Dissertations

The purpose of this study was to explore the effects of vital tooth whitening on tooth color satisfaction, beliefs about dentofacial appearance, and self-esteem in a population 50 years of age and older. A two-group, randomized, pre-test, post-test, single-blind design was utilized following !RB-approval. Sixty-two participants were enrolled. Fifty-three participants (N=53) completed the study with no adverse events reported. Both the control and experimental groups received instructions for a threeweek oral self-care regimen, a toothbrush, toothpaste, and floss. The experimental group also received a tooth whitening product (independent variable) to be used during the same three-week period. Dependent variable measures …

In Vitro Evaluation Of The Reciprocating Disposable Prophylaxis Angle Versus The Rotating Disposable Prophylaxis Angle In Extrinsic Stain Removal Effectiveness, Inma Lacross

Dental Hygiene Theses & Dissertations

The purpose of this study was to determine the extrinsic tooth stain removing effectiveness of a 90° counter-rotating disposable prophylaxis angle (DPA) with rubber cup as compared to the traditional 360° unirotational DPA with rubber cup. Four randomly assigned groups of cleaned, sterilized, extracted human teeth, artificially stained with coffee, tea, tobacco, and red wine were polished on the buccal and lingual surfaces using one of the two rubber cup DP As under study. Each dependent variable (four different stain types) was tested four times with each prophylaxis angle, using each of the four prophylaxis paste conditions, and three different …

Bacillus Anthracis Virulent Plasmid Px02 Genes Found In Large Plasmids Of Two Other Bacillus Species, Vicki A. Luna, Debra S. King, K. Kealy Peak, Frank Reeves, Lea Heberlein-Larson, William Veguilla, L. Heller, Kathleen E. Duncan, Andrew C. Cannons, Philip Amuso, Jacqueline Cattani

Bioelectrics Publications

In order to cause the disease anthrax, Bacillus anthracis requires two plasmids, pX01 and pX02, which carry toxin and capsule genes, respectively, that are used as genetic targets in the laboratory detection of the bacterium. Clinical, forensic, and environmental samples that test positive by PCR protocols established by the Centers for Disease Control and Prevention for B. anthracis are considered to be potentially B. anthracis until confirmed by culture and a secondary battery of tests. We report the presence of 10 genes (acpA, capA, capB, capC, capR, capD, IS1627, ORF 48, ORF 61, and repA) and the sequence for the …

Effects Of Daily Oral Care With 0.12% Chlorhexidine Gluconate And A Standard Oral Care Protocol On The Development Of Nosocomial Pneumonia In Intubated Patients: A Pilot Study, Michelle Bopp, Michele Darby, Karin C. Loftin, Sharon Broscious

Dental Hygiene Faculty Publications

Purpose. The purpose of this pilot study was to determine if a difference existed between nosocomial pneumonia rates for intubated critical care unit (CCU) patients who received twice-daily oral hygiene care with 0.12% chlorhexidine gluconate and those who received the standard oral care. Methods. Over seven months (February to August), CCU patients were identified through screening and informed consent procedures, and randomized into 1 of 2 groups. Over the 7 months, due to the critically ill nature of the patients, only 5 subjects were enrolled. While in the study, twice-daily oral hygiene care consisted of brushing the cheeks, teeth, and …

Dietary Supplements And Sports Performance: Herbals, Melvin H. Williams

Human Movement Sciences & Special Education Faculty Publications

This is the fourth in a series of six articles to discuss the major classes of dietary supplements (vitamins; minerals; amino acids; herbs or botanicals; metabolites, constituents/extracts, or combinations). The major focus is on efficacy of such dietary supplements to enhance exercise or sport performance.

Evaluation Of Toxicity Following Electrically Mediated Interleukin-12 Gene Delivery In A B16 Mouse Melanoma Model, Loree Heller, Kathleen Merkler, Jeffrey Westover, Yolmari Cruz, Domenico Coppola, Kaaron Benson, Adil Daud, Richard Heller

Bioelectrics Publications

PURPOSE: Interleukin-12 (IL-12) has potential as an immunotherapeutic agent for the treatment of cancer but is unfortunately associated with toxicity. Delivery of a plasmid encoding IL-12 with electroporation induces an antitumor effect in the B16 mouse melanoma model without serious side effects. To translate this observation to the clinic, an evaluation of toxicity was done in the mouse model.

EXPERIMENTAL DESIGN: Weight change, tumor response, blood chemistry and hematology values, and serum IL-12 levels were evaluated. Multiple tissues were analyzed histopathologically.

RESULTS: A pronounced reduction in tumor volume, including a large percentage of complete regressions, was observed after electrically mediated …

Effectiveness Of Chlorhexidine-Coating In Controlling Bacterial Quantity On Toothbrush Filaments, Lisa A. Turner

Dental Hygiene Theses & Dissertations

The purpose of this study was to determine if a significant difference exists in the effectiveness· of chlorhexidine-coated nylon brush filaments as compared to uncoated nylon filaments in reducing the quantity of bacteria. Methods: An IRB-approved, two-group, double-blind, randomized, post-test only design was conducted. Sixty-four individuals were randomly assigned to two equal groups of 32. After using the control or experimental toothbrushes for 30-days, participants returned the toothbrushes to the researchers in sealed autoclave bags. In the laboratory, microorganisms were detached from the toothbrush filaments by sonification and vortexing, then plated on both selective and non-selective media at various dilutions …

Traumatic Experiences Contributing To Juvenile Delinquency: A Look At Gender Differences, Alexis L. Correia

Sociology & Criminal Justice Theses & Dissertations

This study investigates the following two research questions: To what extent, if any, do traumatic experiences contribute to juvenile delinquency? To what extent, if any, does gender affect the relationship between trauma and juvenile delinquency? The extent of trauma was reviewed to include various studies relating to the impact trauma has on juveniles. Robert Agnew's General Strain Theory provided support for the differences that exist between males and females when it comes to trauma contributing to juvenile delinquency. Gender differences in emotional response to strain were reviewed, focusing on post-traumatic stress disorder (PTSD). The data that provided support for the …

The Study Of Nitric Oxide Synthase Expression, Function, And Regulation In The Renal Vasculature During Postnatal Renal Development, Brian Blake Ratliff

Theses and Dissertations in Biomedical Sciences

The newborn kidney is vulnerable to vasomotor acute renal failure (ARF) from adverse perinatal events or complications of prematurity. Nitric oxide (NO) vasodilation is vitally protective in this type of ARF, but its relationship with other vasoactive factors, such as angiotensin II (AII) has not been examined. In the immature kidney, nitric oxide synthase (NOS) isoforms, specifically eNOS and nNOS, are developmentally regulated, but their specific role and regulation are unknown.

The enhanced vasodilatory role of NO in the immature kidney was hypothesized to be attributed to regulatory, expressional, and functional differences in eNOS and nNOS isoforms from the adult. …

Teaching And Learning In Urology Nursing, Karen A. Karlowicz

Nursing Faculty Publications

No abstract provided.

Engendering Student Empathy For Disabled Clients With Urinary Incontinence Through Experiential Learning, Karen A. Karlowicz, Kay L. Palmer

Nursing Faculty Publications

As part of a rehabilitation clinical course for senior baccalaureate nursing students, a disability-incontinence experiential learning activity is required. The assignment is intended to familiarize students with some of the challenges encountered by a client with mobility problems, including continence management issues using disposable undergarments. Wearing the undergarments dry and wet while being confined to a wheelchair provides insight and promotes empathy for patients with bladder control problems.

Environmental Justice And The Role Of Social Capital In An Underserved Urban Community, Lorraine Ann Dillon

Community & Environmental Health Theses & Dissertations

The purpose of this qualitative study was to evaluate a community's beliefs, attitudes, and experiences regarding their neighborhood's environmental health issues and the ways in which individuals utilize social capital (the degree to which a community collaborates and cooperates) to improve their environmental health. Research correlating social capital with health status shows that the higher the level of social capital in a community, the better the health. An understanding of why some groups exhibit more social capital than others is important in improving the public health system. The study was accomplished by comparing a convenience sample of two specific groups …

Effect Of A Single Bout Of Prior Moderate Exercise On Cutaneous Perfusion In Type 2 Diabetes, Sheri R. Colberg, Henri K. Parson, Tanja Nunnold, D. Robb Holton, Aaron I. Vinik

Human Movement Sciences & Special Education Faculty Publications

In diabetic individuals, increased shunting of circulation away from the skin may exist, contributing to their greater risk for ulcerations and poor cutaneous healing. In a prospective study (1), we previously found a lower skin perfusion during local heating in the foot dorsum of sedentary type 2 diabetic individuals compared with active people without diabetes. This defect was present despite normal increases in skin interstitial nitric oxide (NO), suggesting that NO is either ineffective or not involved (2). A prior bout of maximal exercise also lessened the impaired responsiveness to local heating of the dorsal foot in active type 2 …

Effects Of Gesture+Verbal Treatment For Noun And Verb Retrieval In Aphasia, Anastasia M. Raymer, Floris Singletary, Amy Rodriguez, Maribel Ciampitti, Kenneth M. Heilman, Leslie J. Gonzalez Rothi

Communication Disorders & Special Education Faculty Publications

Links between verbs and gesture knowledge suggest that verb retrieval may be particularly amenable to gesture+verbal training (GVT) in aphasia compared to noun retrieval. This study examines effects of GVT for noun and verb retrieval in nine individuals with aphasia subsequent to left hemisphere stroke. Participants presented an array of noun and verb retrieval deficits, including impairments of semantic and/or phonologic processing. In a single-participant experimental design, we investigated effects of GVT for noun and verb retrieval in two counterbalanced treatment phases. Effects were evaluated in spoken naming and gesture production to pictured objects and actions. Spoken naming improvements associated …

The Use Of The Tripartite Model Of Attitudes To Explain Ems Providers' Attitudes About The Ems Agenda For The Future, Carolyn Angela Rinaca

Health Services Research Dissertations

A dynamic and revolutionary health care system compels the Nation to develop a more cohesive, unified healthcare workforce. The Emergency Medical Services (EMS) profession has contributed to this development with the publication of the EMS Agenda for the Future. The EMS Agenda for the Future describes the future direction for emergency medical services agencies and organizations within the nation. It is a vision that integrates EMS systems with other health care professions. The EMS Agenda for the Future is designed to assist EMS professionals in realizing their full potential for proficiency and contributes to the development of the EMS profession. …

Never Let Me Clone? Countering An Ethical Argument Against The Reproductive Cloning Of Humans, Yvette Pearson

Philosophy Faculty Publications

In the March 2006 issue of EMBO reports, Christof Tannert, a bioethicist at the Max Delbrück Research Centre in Berlin, Germany, presented a moral argument against human reproductive cloning on the basis of Immanuel Kant’s categorical imperative (Tannert, 2006). In this article, I address some problems with Tannert’s views and show that our concerns about this prospective procedure should prompt us to scrutinize carefully the conventional procreative practices and attitudes. Indeed, if we set aside objections that are grounded in genetic determinism, many of the offensive features of human cloning are identical to problems with procreation by more conventional means, …

Understanding The Nature Of Surgical Excellence Using A Competency Modeling Approach, Hope S. Hanner-Bailey

Psychology Theses & Dissertations

Currently, a thorough description of the knowledge, skills, abilities, and other personal characteristics (KSAOs) that distinguish an exceptional surgeon does not exist. This knowledge is pertinent to the development of selection, training, and performance assessment methods that can be used to develop high performing surgeons. Expert surgeons from around the country were recruited to participate in an interview to discuss the KSAOs (i.e., the competencies) needed to be exceptional in the field. A smaller number of novice surgeons were also interviewed. The expert interview data were distilled into a competency model that consists of ten competencies and patterns within the …

Sulcular Sulfide Monitoring: An Indicator Of Early Dental Plaque-Induced Gingival Disease, Aleksandra Pavolotskaya, Gayle Mccombs, Michele Darby, Kenneth Marinak, Naik N. Dayanand

Dental Hygiene Faculty Publications

Purpose. The purpose of this study was to evaluate the relationship between volatile sulfur compounds (VSC) and gingival health status and to determine if volatile sulfur compounds can detect early dental plaque-induced gingival disease. Methods. A split-mouth design with randomly selected quadrants of the mandibular arch enabled 39 participants to serve as their own controls. At baseline and at three subsequent appointments (days 7, 14, and 21) gingival inflammation (GI), bleeding on probing (BOP), and sulfide levels (SUL) were measured using the Gingival Index and the Diamond Probe/Perio 2000 System. For three weeks, participants refrained from brushing and flossing one …

Looking At Gender Differences Through The Lens Of Sport Spectators, Lynn Ridinger, Daniel C. Funk

Human Movement Sciences & Special Education Faculty Publications

This paper explores common assumptions about the intrinsic differences between male and female consumers within a subset of leisure consumption - sport spectating. This research utilized the Sports Interest Inventory (SII) (Funk, Mahony & Ridinger, 2002) to examine differences between spectators (N = 959) attending men's and women's basketball games at a NCAA Division I institution. MANOVA results revealed nine differences for Team-Gender, seven differences for Spectator-Gender, and three interaction effects. Multiple linear regression analyses revealed that three core interest factors (university pride, team interest, and vicarious achievement) explained a significant proportion of variance in commitment and attendance behavior for …

Word-Retrieval Treatment In Aphasia: Effects Of Sentence Context, Anastasia Raymer, Francine Kohen

Communication Disorders & Special Education Faculty Publications

Word-retrieval treatment studies in aphasia have reported the greatest influences on picture naming for trained words. To increase treatment effects to untrained words and sentence contexts, we investigated a sentence-reading treatment hierarchy that moves from errorless to generative production of sentences incorporating target nouns and verbs. In an individual with nonfluent aphasia, treatment resulted in improved picture naming for nouns and verbs and generalized increases in numbers of grammatical sentences and content words following noun therapy. A second individual with fluent aphasia improved little in picture-naming and sentence-generation tasks for both nouns and verbs. This sentence-based word-retrieval training, in which …

The Criminal Justice Response To Elder Abuse In Nursing Homes: A Routine Activities Perspective, Brian K. Payne, Randy R. Gainey

Sociology & Criminal Justice Faculty Publications

Politicians and researchers have begun to pay more attention to elder abuse in recent times. Most of the research on elder abuse has focused on cases of abuse perpetrated by family members, treating the phenomenon as a social problem, but it is increasingly being conceptualized as a crime problem. The current study examines elder abuse in nursing homes from a criminological perspective. Using routine activities theory as a guide, particular attention is given to the criminal justice system's response to abusive activities committed by nursing home employees. In all, 801 cases of abuse investigated by Medicaid Fraud Control Units are …

Oral Cancer Prevalence In Virginia, Karin C. Loftin, Michele Darby, Stacey Plichta, Sophie Thompson, Shreeram Kumar, Louis Abbey

Dental Hygiene Faculty Publications

Purpose. Oral and pharyngeal cancer affects 30,000 Americans a year and kills one fourth of those diagnosed. The primary risk factors for oral cancer are past or present cigarette and tobacco usage, and alcohol consumption in conjunction with tobacco use. Even though the prevalence of oral cancer is relatively low in the younger age groups, this group is most likely to benefit from intervention programs designed to change risky behavior such as smoking, and to prevent oral cancer in the later years. The goal of the study was to identify high-risk target areas for an oral cancer prevention program in …

Are Residents' Extended Shifts Associated With Adverse Events, Mariana Szklo-Coxe

Community & Environmental Health Faculty Publications

First paragraph:

Heated debates and controversies surrounding the regulation of medical residents’ work hours have raged for over twenty years. In the wake of Libby Zion’s untimely death in 1984 and resulting recommendations by the Bell Commission, New York State enacted legislation (Code 405.4) governing residents’ working conditions and supervision [1]. Since then, there has been growing interest in regulating residents’ work hours, culminating recently (2003–2004) in national guidelines and legislation on duty-hour restrictions both in the United States and Europe [2,3].

The Comparative Effects Of 0.12% Chlorhexidine And Herbal Oral Rinse On Dental Plaque-Induced Gingivitis, Elizabeth N. Southern, Gayle B. Mccombs, S. L. Tolle, Ken Marinak

Dental Hygiene Faculty Publications

PURPOSE: The purpose of this study was to determine the effects of two oral rinses-one 0.12% chlorhexidine rinse (CHX) and one herbal rinse (HBR)-on gingival health status over time.

METHODS: Sixty-three participants were randomly assigned to one of three treatment groups: CHX, HBR, or placebo. For three months, participants rinsed twice daily (morning and evening) with (1/2) ounce of allocated rinse after brushing and flossing. Individuals were given the same type of soft bristle toothbrush and whitening toothpaste. No attempt was made to modify participants' routine oral care, except they were advised to refrain from use of any other oral …

Changes In Immunological And Hematological Parameters Of Female Residents Exposed To Volatile Organic Compounds In The City Of Kaohsiung, Taiwan, Hueiwang Anna Jeng, I-Long Lee, Yang-Yen Gau, Ching-Tzu Yang, Chitsan Lin, Yu-Jue Hong

Community & Environmental Health Faculty Publications

The objective of this study was to assess the effects, if any, of volatile organic compounds (VOCs) in the ambient air of Kaohsiuug, Taiwan, on certain hematological and immunological parameters of 153 female study participants. The major source of VOCs was vehicle emissions. The participants were selected from three areas, each area at a different distance from a freeway. Results indicated that total concentrations of VOCs and a subgroup of 25 VOCs (VOC₂₅.) ranged from 250 to 335 ppb and 89 to 113 ppb, respectively. The distribution of VOC concentrations did not correlate with distance from the freeway. …

The Use Of Proteomic Technologies To Identify Serum Glycoproteins For The Early Detection Of Liver And Prostate Cancers, Elizabeth Ellen Schwegler

Theses and Dissertations in Biomedical Sciences

The application of proteomic technologies to identify serum glycoproteins is an emerging technique to identify new biomarkers indicative of disease severity. Many of these newly evolving protein-profiling methodologies have evolved from previous global protein expression profiling studies such as those involving SELDI-TOF-MS technologies. Though the SELDI approach could distinguish disease from normal by utilizing protein patterns as shown herein with the HCC study of chapter II, it was unable to offer sequence information on the selected peaks, and did not have the ability to analyze the entire dynamic range of the serum/plasma proteome. To address these deficiencies, new strategies that …