Medicine and Health Sciences Commons^™

Development Of The Profession Of Counseling In Kenya, Uganda, And Tanzania: A Grounded Theory Study, Mueni Joy Maweu Mwendwa

Counseling & Human Services Theses & Dissertations

The positive mental health of a country's population has a direct correlation to that country's economic and social advancement. As a result, the development of the counseling profession is critical. Even though fewer than half of African member states have an existing mental health policy in place, initiatives to establish mental health policies and develop the counseling profession are underway across the African continent. In general, there is a significant deficit of counseling literature, and specifically, research on the development of the counseling profession in Africa. This grounded theory study sought to explore the experiences of counseling leaders related to …

Mouse Oocyte Maturation And Embryo Development After Exposure To Vemurafenib (Plx4032), An Anti-Melanoma B-Raf V600e Inhibitor, Bo Liu

Theses and Dissertations in Biomedical Sciences

Vemurafenib is a selective B-Raf^V600E inhibitor in melanoma targeted therapy which also inhibits the wild type B- and C-Raf. In oocyte maturation, the C-Raf/MAPK pathway acts as an important self-enhancing and promoting system, w hereas in embryo development, the C-Raf/M APK pathway participates in pre- and post- implantation embryo proliferation and differentiation.

The hypothesis: Vemurafenib has detrimental effects on oocyte maturation and/or embryo development. Mouse oocytes and one cell (1C) mouse embryos were tested by ex vivo culturing with Vemurafenib in serial dilution. Oocytes were evaluated by cell cycle morphology, spindle formation and chromosomal alignment by im munofluorescence (IF) …

Electrotransfer Of Single-Stranded Or Double-Stranded Dna Induces Complete Regression Of Palpable B16.F10 Mouse Melanomas, Loree Heller, Vesba Todorovic, Maja Cemazar

Bioelectrics Publications

Enhanced tumor delivery of plasmid DNA with electric pulses in vivo has been confirmed in many preclinical models. Intratumor electrotransfer of plasmids encoding therapeutic molecules has reached Phase II clinical trials. In multiple preclinical studies, a reduction in tumor growth, increased survival or complete tumor regression have been observed in control groups in which vector or backbone plasmid DNA electrotransfer was performed. This study explores factors that could produce this antitumor effect. The specific electrotransfer pulse protocol employed significantly potentiated the regression. Tumor regression was observed after delivery of single-stranded or double-stranded DNA with or without CpG motifs in both …

Visiting Lecturer Will Link Public Health Risks To Climate Change, Public Affairs & News Bureau, Old Dominion University

News Items

No abstract provided.

Use Of Immersive Visualization For The Control Of Dental Anxiety During Dental Hygiene Treatment, Carmelo Padrino-Barrios

Dental Hygiene Theses & Dissertations

Purpose: The purpose of this study was to determine the effectiveness of immersive visualization (IV) therapy, a technique that provides visual and stereoscopic display through the use of eyewear, in anxious patients during an oral prophylaxis. Methods: A convenience sample of thirty adults was enrolled. A split mouth design was utilized. Subjects were randomly divided into two groups: group A (use of IV for the right side of the mouth), and group B (use of IV for the left side of the mouth). Subjects received a full mouth oral prophylaxis (removal of supra and subgingival calculus and selective polishing), always …

Regulation Of Hyaluronate Lyase (Hyla) Expression By Regr A Transcriptional Repressor In Streptococcus Pyogenes, Alexis A. Kordis

Biological Sciences Theses & Dissertations

Streptococcus pyogenes, group A streptococci (GAS), causes diseases ranging from asymptomatic to life threatening. Some strains of S. pyogenes produce extracellular hyaluronate lyase (HylA), a potential virulence factor. HylA is an enzyme that degrades hyaluronic acid, which is found in the extracellular matrix of human tissues. The breakdown of the host tissue contributes to the spread of infection. The hylA gene is not constitutively expressed in vitro, which implies regulation.

A proposed regulator of hyaluronate lyase expression is RegR, a LacI/GalR like protein. A vector containing disrupted regR was electro-transformed into S. pyogenes M-type 22 strain 10403. Growth characteristics …

Effect Of A Lateral Wedge Insole Over A One Week Period In A Healthy Population, Sarah E. Sudheimer

Human Movement Studies & Special Education Theses & Dissertations

Medial knee osteoarthritis is a disease that is projected to affect approximately 45% of the U.S. population and is associated with significant morbidity, chronic pain, and limited activity. Laterally wedged insoles are used as an intervention to laterally shift the mechanical axis of the limb and decrease the external knee adduction moment, possibly indicating a shift in load distribution to the lateral compartment of the knee. The aim of this study was to examine the acute effects of a laterally wedged insole in those with valgus and normally aligned knees and to determine prolonged effects after the insole was worn …

Student Retention In Bsn Programs, Katherine Pittman Hensley

Educational Leadership & Workforce Development Theses & Dissertations

This study examined, by use of a researcher-developed survey instrument, perceptions between three groups on reasons why students drop out of nursing programs. Also examined are recommendations from the three groups on how to try to avoid nursing student attrition. Specific groups surveyed included native BSN students, RNB students, and a mixed group of nursing faculty. Survey items were divided into two general groups: student-related issues, and institutional issues. Since RNB students (which include a larger number of non-traditional students) and BSN students (which include more of the native university population of traditional students) have many differences, the author attempted …

Child Emotional Abuse And Its Relationship To Obesity, Kelly Anderson Driscoll

Sociology & Criminal Justice Theses & Dissertations

Over the past 30 years in the United States childhood obesity has more than tripled (Center for Disease Control and Prevention, 2010). In 2008, 18.5% of adolescents of the age 12-18 years old were obese in the United States (Center for Disease Control and Prevention, 2010). With the increase of obesity Americans have spent approximately 9% of their total medical costs on obesity-related illnesses (Finkelstein, Fiebelkorn, &Wang, 2003). Previous research documented the relationship between virtually every form of child abuse and subsequent obesity. Restricting focus to child emotional abuse, while studies have linked emotional abuse to the long-term consequence of …

Experiences Of Resident Assistants With Potentially Suicidal Students: Identification, Referral, And Expectations, Katherine M. Bender

Counseling & Human Services Theses & Dissertations

Resident Assistants (RAs), living on campus and tasked with advising students while keeping them safe, are in a position to identify and refer students who may be at risk for suicide or other mental health issues. This study examined RA ability to identify students at risk for suicide, RA comfort in working with students at risk for suicide, RA actions taken when working with students who may be at risk for suicide, and RA expectations for shared information about students the RAs have referred for counseling because they may be at risk for suicide. The study found that RAs report …

In Vitro Selection Of Chloroquine Tolerant Plasmodium Falciparum Parasites, Daniel A. Daley

Biological Sciences Theses & Dissertations

Malaria is among the most devastating human diseases, and a majority of lethal cases are caused by the protozoan parasite, Plasmodiumfalciparum. The emergence of multi-drug resistant P.falciparum is a major obstacle to malaria control and is highlighted by the abandonment of chloroquine (CQ) as a first-line treatment of P.falciparum infections worldwide. Chloroquine resistance (CQR) is associated primarily with mutations in the transmembrane digestive vacuole protein, PfCRT. However, CQR P.falciparum parasites harboring the same mutant pfcrt allele vary in their CQ response, suggesting the CQ response is multigenic in nature. No gene outside of pfcrt is completely associated with CQR. Thus, …

Section Abstracts: Medical Science

Virginia Journal of Science

Abstracts of the Medical Science Section for the 91st Annual Virginia Journal of Science Meeting, May 2013

91st Annual Meeting Of The Virginia Academy Of Science: Proceedings

Virginia Journal of Science

Proceedings of the 91st Annual Meeting of the Virginia Academy of Science, held at Virginia Polytechnic Institute and State University, May 22-24, 2013.

Distribution, Prevalence, And Genetic Analysis Of Panulirus Argus Virus 1 (Pav1) From The Caribbean Sea, Jessica Moss, Donald C. Behringer Jr., Jeffrey D. Shields, Antonio Baeza, Alfonso Aguilar-Perera, Phillippe G. Bush, Clement Dromer, Alejandro Herrera-Moreno, Lester Gittens, Thomas R. Matthews, Michael R. Mccord, Michelle T. Schärer, Lionel Reynal, Nathanial Truelove, Mark J. Butler Iv

Biological Sciences Faculty Publications

The pathogenic virus Panulirus argus virus 1 (PaV1) was first discovered in Caribbean spiny lobsters Panulirus argus from the Florida Keys (USA) in 1999 and has since been reported in Belize, Mexico, and Cuba; its distribution in the wider Caribbean is unknown. We collected tissue samples from adult spiny lobsters from 30 locations in 14 countries bordering the Caribbean Sea and used molecular diagnostics to assay for the presence of PaV1. PaV1 occurred primarily in the northern areas of the Caribbean, where its prevalence was highest. The virus was not found in lobsters from the southeastern Caribbean, and its prevalence …

Protective Behavioral Strategy Subtypes As Moderators Of The Relationship Between Alcohol Consumption And Alcohol-Related Problems, Benjamin A. Kite

Psychology Theses & Dissertations

Protective behavioral strategy (or drinking control strategy) use is widely regarded as an effective tool for reducing negative consequences from consuming alcohol (Martens et al., 2005; Martens et al., 2008). Research has shown that frequent protective behavioral strategy use buffers the relationship between alcohol consumption and alcohol-related problems (Borden et al., 2011), and that gender moderates this effect (Benton et al., 2004); however. The present research was used to expand on previous research showing that protective behavioral strategy use can buffer the relationship between alcohol consumption and alcohol-related problems. Further, the assessment of protective behavioral strategy use across gender was …

Changes In The Dynamics Of Postural And Locomotor Control As A Result Of Varying Task Demands, Kathleen Sherry Thomas

Human Movement Studies & Special Education Theses & Dissertations

The aim of this study was to examine changes in postural and locomotor control under varying task demands. Three experiments were designed to address the impact that fast walking had on standing posture over time, slow walking had on gait dynamics over time, and the extent to which gait speed interacts with the ability to walk randomly.

For experiment I, the aim was to identify the time course in which postural adaptation occurred while walking at faster than preferred speeds. Postural motion was assessed at specific intervals over a 35-min walking trial. Findings revealed that walking at a faster speed …

Fluorescent Technology Versus Visual And Tactile Examination In The Detection Of Oral Lesion: A Pilot Study, Hadeel Mohammed Ayoub

Dental Hygiene Theses & Dissertations

Purpose: The purpose of the study was to compare the effectiveness of the VELscope® Vx, versus a visual and tactile intraoral examination in detecting oral lesions in an adult, high risk population. Methods: A convenience sample of 30 participants (17 cigarette smokers and 13 dual addiction smokers) was enrolled. For the purpose of this study, dual addition was defined as cigarettes plus hookah usage. Two trained and calibrated dental hygienists conducted all examinations. Visual and tactile intraoral examinations were conducted, followed by VELscope® Vx florescence examinations. All subjects received an inspection of the lips, labial mucosa, buccal mucosa, floor of …

Comparing Velscope Vx And Traditional Oral Exams In Shisha (Hookah) Smokers: A Pilot Study, Amanda E. Kimball

Dental Hygiene Theses & Dissertations

The purpose of this study was to compare oral findings using two exam types, the VELscope Vx® screening device versus a modified oral examination in detecting oral potentially malignant lesions in shisha smokers.

Methods: Thirty-one participants who reported currently smoking shisha and tobacco were recruited. Participants were identified for smoking habits to include two groups, to include those who reported smoking shisha exclusively and those who reported smoking shisha and tobacco. Each group received both exam types; examiners used a standardized protocol. A health history questionnaire was also collected to assess participant's oral cancer risk factors such as age, race, …

Effects Of An Interprofessional Simulation Activity To Improve Students' Perceptions Of Other Healthcare Professions, Chase Raymond Poulsen

STEMPS Theses & Dissertations

Healthcare professionals have historically been educated and trained by members of their own profession within a curriculum that reinforces their individual discipline-specific strengths. This differentiation has contributed to students having little interaction with other professionals until after they have entered the workforce and consequently little formal education in collaboration or integration. The purpose of this mixed-method study was to evaluate the impact of an interprofessional (IP) collaborative activity on student's perceptions of the others discipline for the improvement in care of medical patients.

The sample population consisted of students from two programs, nursing (n=40) and respiratory therapy (n=33). Students were …

Patterns Of Gene Expression From Human Costal Cartilage In Relation To The Chest Wall Deformity Pectus Carinatum, Janna E. Grubbs

Biological Sciences Theses & Dissertations

Cartilage deformities within the human chest wall, specifically pectus excavatum (PE) and pectus carinatum (PC) are common (1/400-1/1000) and yet, despite their clinical significance, are some of the least studied disorders pertaining to cartilage [1]. The costal cartilage connecting "false ribs" 8-10 to the sternum is often abnormally grown and can lead to formation of a severely sunken "funnel" chest (PE) or push outwards to form a "pigeon" chest (PC). Both conditions can have impact on the diaphragm, heart, lungs, and psychological function. An established ratio of PE and PC in males to females is 4:1, indicating a sex-linked male …

Investigating Similarities And Differences As Measured By The Durel And Gsq Between Three Subgroups Attending A Local Aa Meeting To Develop A Profile Of Long Term Attendees, Keesha Masean Kerns

Counseling & Human Services Theses & Dissertations

Alcoholics Anonymous groups are growing in popularity due to their cost effectiveness and history of dependability. Although the program clearly has the numbers to support its popularity, skeptics continually analyze its claims of effectiveness through research. While research pertaining to AA is diverse, very little is presented concerning factors that contribute to retention in the program. The primary purpose for this quantitative study was to investigate the similarities and differences in the various stages of participants of a sample attending a local AA program, identify variables that contribute to retention in the AA sample, and to use Grounded Theory to …

Novel Architecture Of Costal Cartilage And Implications In Chest Wall Deformities, Anthony J. Asmar

Biological Sciences Theses & Dissertations

Costal cartilage is a type of hyaline cartilage that forms rod-like structures that connect the ribs to the sternum. Deformation of costal cartilage is observed in the chest wall deformities, pectus excavatum and pectus carinatum. Pectus excavatum involves a sternal displacement causing a depression of the chest while pectus carinatum causes a protrusion of the chest. As costal cartilage is not a widely studied tissue, this leaves little knowledge into possible factors involved in the pathogenesis of pectus deformities. Costal cartilage in these deformities has been described as being weakened and may implicate proteoglycans which play an important role in …

Special Issue On Medical Simulation, Michel Audette, Hanif M. Ladak

Computational Modeling & Simulation Engineering Faculty Publications

We would like to welcome you to this Special Issue on Medical Simulation, the first of its kind not only for SIMULATION: Transactions of The Society for Modeling and Simulation International, but for any technical journal. Our respective backgrounds are an indication of the technical and clinical breadth of medical simulation, as we approach the subject as primarily medical image analysis and biomechanics experts respectively, each with a variety of clinical interests spanning virtual reality (VR)–based neuro-, orthopedic and ear-nose-and-throat surgery. Moreover, we believe that the breadth of the papers that comprise this issue reflects an even broader perspective. After …

Nucleic Acid Oxidation In Human Health And Disease, Mu-Rong Chao, Pavel Rossner Jr., Siamak Haghdoost, Hueiwang Anna Jeng, Chiung-Wen Hu

Community & Environmental Health Faculty Publications

No abstract provided.

Influence Of Exposure To Benzo[A]Pyrene On Mice Testicular Germ Cells During Spermatogenesis, Hueiwang Anna Jeng, Silvina M. Bocca

Community & Environmental Health Faculty Publications

The objective of this study was to assess the toxicological effect of exposure to benzo(a)pyrene, B[a]P, on germ cells during spermatogenesis. Mice were exposed to B[a]P at 1, 10, 50, and 100 mg/kg/day for 30 days via oral ingestion. Germ cells, including spermatogonia, spermatocytes, pachytene spermatocytes, and round spermatids, were recovered from testes of mice exposed to B[a]P, while mature spermatozoa were isolated from vas deferens. Reproductive organs were collected and weighed. Apoptotic response of germ cells and mature spermatozoa were qualified using the terminal deoxynucleotidyl transferase mediated deoxy-UTP nick end labeling (TUNEL) assay. B[a]P exposure at

Nocturnal Diaphoresis Secondary To Mild Obstructive Sleep Apnea In A Patient With A History Of Two Malignancies, Robert Daniel Vorona, Mariana Szklo-Coxe, Mark Fleming, J. Catesby Ware

Community & Environmental Health Faculty Publications

Numerous medical disorders, including obstructive sleep apnea, may cause nocturnal diaphoresis. Previous work has associated severe obstructive sleep apnea with nocturnal diaphoresis. This case report is of import as our patient with severe nocturnal diaphoresis manifested only mild sleep apnea, and, for years, his nocturnal diaphoresis was ascribed to other causes, i.e., first prostate cancer and then follicular B-cell lymphoma. Additionally, it was the nocturnal diaphoresis and not more common symptoms of obstructive sleep apnea, such as snoring, that led to the definitive diagnosis of his sleep apnea and then to treatment with a gratifying resolution of his onerous symptom.

The Relation Of Socioeconomic Status, Parental Education, Vocabulary And Language Skills Of Children Who Stutter, Corrin G. Richels, Kia N. Johnson, Tedra A. Walden, Edward G. Conture

Communication Disorders & Special Education Faculty Publications

Purpose: The purpose of this project was to investigate the possible relation between standardized measures of vocabulary/language, mother and father education, and a composite measure of socioeconomic status (SES) for children who do not stutter (CWNS) and children who stutter (CWS).

Methods: Participants were 138 CWNS and 159 CWS between the ages of 2;6 and 6;3 and their families. The Hollingshead Four Factor Index of Social Position (i.e., Family SES) was used to calculate SES based on a composite score consisting of weighted values for paternal and maternal education and occupation. Statistical regression analyses were conducted to investigate the relation …

The Role Of Is Infrastructure And Organizational Context On Implementation Of Electronic Health Records Systems, Pilar Pazos, Anjee Gorkhali, Rolando Delaguila

Engineering Management & Systems Engineering Faculty Publications

This research explores the role that Information System (IS) infrastructure and organizational context play on the implementation of Electronic Health Records (EHR) Systems. A number of indicators can be used as a proxy for IS infrastructure such as: Information System (IS) Department Budget allocation, percentage of full time IS staff and the number of technical trainings provided by the IS department to the clinical staff. Data was obtained from the Healthcare Information and Management Systems Society (HIMSS) database, a non-for profit organization that evaluates the use of information technology in the health care industry. This paper reports on the development …

Comparing Responsiveness Of Six Common Patient-Reported Outcomes To Changes Following Autologous Chondrocyte Implantation: A Systematic Review And Meta-Analysis Of Prospective Studies, Jennifer S. Howard, Christian Lattermann, Johanna M. Hoch, Carl G. Mattacola, Jennifer M. Medina Mckeon

Rehabilitation Sciences Faculty Publications

Objective: To compare the responsiveness of six common patient-reported outcomes (PROs) following autologous chondrocyte implantation (ACI). Design: A systematic search was conducted to identify reports of PROs following ACI. Study quality was evaluated using the modified Coleman Methodology Score (mCMS). For each outcome score, pre- to postoperative paired Hedge's g effect sizes were calculated with 95% confidence intervals (CIs). Random effects meta-analyses were performed to provide a summary response for each PRO at time points (TP) I (<1 year), II (1 year to <2 years), III (2 years to <4 years), IV (>= 4 years), and overall. Results: The mean mCMS for the 42 articles included was 50.9 +/- 9.2. For all evaluated instruments, …

A Feedback Inclusive Neuromuscular Training Program Alters Frontal Plane Kinematics, Eric K. Greska, Nelson Cortes, Bonnie L. Van Lunen, James A. Oñate

Rehabilitation Sciences Faculty Publications

-Anterior cruciate ligament (ACL) neuromuscular training programs have demonstrated beneficial effects in reducing ACL injuries, yet further evaluation of their effects on biomechanical measures across a sports team season is required to elucidate the specific factors that are modifiable. The purpose of this study was to evaluate the effects of a 10-week off-season neuromuscular training program on lower extremity kinematics. Twelve Division I female soccer players (age: 19.2 ± 0.8 years, height: 1.67 ± 0.1 m, weight: 60.2 ± 6.5 kg) performed unanticipated dynamic trials of a running stop-jump task pretraining and posttraining. Data collection was performed using an 8-camera …