Medicine and Health Sciences Commons^™

Doctoral Education And Preparation For Nursing Faculty Roles, Angela M. Mcnelis, Kristina Dreifuerst, Rhonda Schwindt

College of Nursing Faculty Research and Publications

Background

Despite increased enrollment in doctoral programs and the encouraging numbers of graduates intending to pursue faculty positions, lack of adequate preparedness to assume the faculty role may adversely impact retention and consequently undermine efforts to reduce the shortage.

Purpose

Understanding doctoral nursing students’ and recent graduates’ expectations of their educational experience related to preparation for an academic career is needed to inform curricular revisions and advise guidance to ensure role readiness.

Methods

A secondary analysis of 24 interviews with current PhD and doctor of nursing practice (DNP) students and recent graduates from both degree programs was performed to gain …

Pilot Evaluation Of A New Urine Progesterone Test To Confirm Ovulation In Women Using A Fertility Monitor, Thomas Bouchard, Richard J. Fehring, Mary Schneider

College of Nursing Faculty Research and Publications

Background

Progesterone rises ~24–36 h after ovulation. Past studies using ultrasound-confirmed ovulation have shown that three consecutive tests with a threshold of 5μg/mL of urine progesterone (pregnanediol-3-glucuronide, PDG), taken after the luteinizing hormone (LH) surge, confirmed ovulation with 100% specificity.

Purpose

The purpose of this study was to a evaluate a new urine PDG self-test to retrospectively confirm ovulation in women who were monitoring ovulation using a hormonal fertility monitor.

Methods

Thirteen women of reproductive age were recruited to test urine PDG while using their home hormonal fertility monitor. The monitor measured the rise in estrogen (estrone-3-glucuronide, E3G) and LH …

Circuit-Specific Control Of The Medial Entorhinal Inputs To The Dentate Gyrus By Atypical Presynaptic Nmdars Activated By Astrocytes, Iaroslav Savtchouk, Maria Amalia Di Castro, Rugina Ali, Hiltrud Stubbe, Rafael Lujan, Andrea Volterra

Biomedical Sciences Faculty Research and Publications

Here, we investigated the properties of presynaptic N-methyl-D-aspartate receptors (pre-NMDARs) at corticohippocampal excitatory connections between perforant path (PP) afferents and dentate granule cells (GCs), a circuit involved in memory encoding and centrally affected in Alzheimer’s disease and temporal lobe epilepsy. These receptors were previously reported to increase PP release probability in response to gliotransmitters released from astrocytes. Their activation occurred even under conditions of elevated Mg²⁺ and lack of action potential firing in the axons, although how this could be accomplished was unclear. We now report that these pre-NMDARs contain the GluN3a subunit conferring them low Mg^{2+ …}

Effect Of Heat-Treatment Time On Bending Properties Of Cobolt-Chromium Orthodontic Wires, Melanie Hammerbeck

Master's Theses (2009 -)

Different protocols appear in the literature with respect to heat-treating cobalt-chromium orthodontic wires. The objective was to determine the effect of variable heat-treatment time and method on the bending properties of CoCr wires. Two tempers of CoCr ‘Elgiloy’ wires (Rocky Mountain Orthodontics), blue (B) and yellow (Y), were heat-treated for different durations. The groups (n=20/group/temper) included: 1) as-received (control); 2) brush-flame; 3) 480oC for 5sec; 4) 480oC for 10min; 5) 480oC for 2hr; and 6) 480oC for 5hr. Wire segments were tested by a three-point bend test. Stiffness/flexural modulus, percent recovery, and force values at select deflections were statistically compared …

Practical Guidance For Engaging Patients In Health Research, Treatment Guidelines And Regulatory Processes: Results Of An Expert Group Meeting Organized By The World Health Organization (Who) And The European Society For Clinical And Economic Aspects Of Osteoporosis, Osteoarthritis And Musculoskeletal Diseases (Esceo), Maarten De Wit, Cyrus Cooper, Peter Tugwell, Nathalie Bere, John Kirwan, Philip G. Conaghan, Charlotte Roberts, Isabelle Aujoulat, Nasser Al-Daghri, Islene Arajujo De Carvalho, Mary Barker, Nicola Bedlington, Maria Luisa Brandi, Olivier Bruyère, Nansa Burlett, Philippe Halbout, Mickaël Hiligsmann, Famida Jiwa, John A. Kanis, Andrea Laslop, Wendy Lawrence, Daniel Pinto, Concepción Prieto Yerro, Véronique Rabenda, René Rizzoli, Marieke Scholte-Voshaar, Mila Vlaskovska, Jean-Yves Reginster

Physical Therapy Faculty Research and Publications

There is increasing emphasis on patient-centred research to support the development, approval and reimbursement of health interventions that best meet patients’ needs. However, there is currently little guidance on how meaningful patient engagement may be achieved. An expert working group, representing a wide range of stakeholders and disciplines, was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the World Health Organization (WHO). Through a structured, collaborative process the group generated practical guidance to facilitate optimal patient engagement in clinical development and regulatory decisions. Patient engagement is a relational process. The …

Practical Guidance For Engaging Patients In Health Research, Treatment Guidelines And Regulatory Processes: Results Of An Expert Group Meeting Organized By The World Health Organization (Who) And The European Society For Clinical And Economic Aspects Of Osteoporosis, Osteoarthritis And Musculoskeletal Diseases (Esceo), Maarten De Wit, Cyrus Cooper, Peter Tugwell, Nathalie Bere, John Kirwan, Philip G. Conaghan, Charlotte Roberts, Isabelle Aujoulat, Nasser Al-Daghri, Islene Arajujo De Carvalho, Mary Barker, Nicola Bedlington, Maria Luisa Brandi, Olivier Bruyère, Nansa Burlett, Philippe Halbout, Mickaël Hiligsmann, Famida Jiwa, John A. Kanis, Andrea Laslop, Wendy Lawrence, Daniel Pinto, Concepción Prieto Yerro, Véronique Rabenda, René Rizzoli, Marieke Scholte-Voshaar, Mila Vlaskovska, Jean-Yves Reginster

Physical Therapy Faculty Research and Publications

There is increasing emphasis on patient-centred research to support the development, approval and reimbursement of health interventions that best meet patients’ needs. However, there is currently little guidance on how meaningful patient engagement may be achieved. An expert working group, representing a wide range of stakeholders and disciplines, was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the World Health Organization (WHO). Through a structured, collaborative process the group generated practical guidance to facilitate optimal patient engagement in clinical development and regulatory decisions. Patient engagement is a relational process. The …

Efficacy Of Invisalign Attachments: A Retrospective Study, Theresa Karras

Master's Theses (2009 -)

Objective: To compare the efficacy of Invisalign’s (Align Technology, Inc., Santa Clara, CA) optimized and conventional attachments on rotational and extrusive tooth movements.Materials and Methods: Initial, predicted, and achieved digital dental models from 100 orthodontic patients were exported from Invisalign’s ClinCheck software as stereolithography (STL) files and subsequently imported into the Slicer CMF program (open source, version 4.7.0) for superimpositions on posterior teeth with no planned movement. Rotational and extrusive measurements for both optimized and conventional attachment types were made on 382 teeth from the superimposition of the initial and predicted models (“predicted movement”) and from the superimposed initial and …

The Cytotoxicity Effect Of Silver Solder Materials On Human Periodontal Ligament Fibroblast Cells, Joseph Jeffrey Curry

Master's Theses (2009 -)

Objectives:Orthodontic appliances with silver soldering can be in the oral cavity for several years and very few studies have been done to detect the biosafety of the silver solders. The aim of this in vitro study was to compare the cytotoxicity effects of two different solder materials on Human Periodontal Ligament Fibroblast cells (HPLF).Methods:Two commonly used solder materials from two companies, (Leone and Summit) with different metal elements and percentages were studied. The solder samples were exposed to HPLF cells for 48 hours and the cytotoxicity effect of soldered materials on HPLF cells was measured via the MTT colorimetric assay …

The Effect Of Mechanical Vibration On Alveolar Bone Following Experimental Periodontitis - A Micro-Ct Study, Andrei Dan Taut

Master's Theses (2009 -)

Introduction: Vibration in the form of high frequency, low magnitude acceleration has paradoxical effects on craniofacial bones – with anabolic effects under physiological conditions and catabolic effects in the presence of inflammation. The objectives of this study are to establish a murine model for periodontitis and to investigate the effects of high frequency, low magnitude mechanical vibration on alveolar bone following ligature- induced experimental periodontitis.Materials and Methods: Ninety-five 11-week-old inbred strain C57BL/67 male mice were randomly assigned into four groups: 1) healthy control (n = 9); 2) healthy + mechanical vibration (n = 8); 3) experimental periodontitis + no treatment …

Evaluation Of Corrosion Mechanisms In Stainless Steel Orthodontic Retainer Wires, Jamie Martin

Master's Theses (2009 -)

Title: Evaluation of Corrosion Mechanisms in Stainless Steel Orthodontic Retainer WiresAuthors: Jamie Martin, Ghada Nimeri, David BerzinsObjective:Orthodontic retainers fabricated from stainless steel wire and acrylic are prone to several types of corrosion in the oral environment, including stress, crevice, and galvanic corrosion. The aim of this study was to determine the relative effect of stress corrosion, galvanic corrosion, and crevice corrosion on stainless steel retainer wires.Methods:Three different brands of 0.032-inch stainless steel wires were tested. Six new segments (2-inch length) of each brand of wire were tested in each of four tests: 1) in an artificial saliva solution to determine …

Enhancing Cell Seeding And Osteogenesis Of Mscs On 3d Printed Scaffolds Through Injectable Bmp2 Immobilized Ecm-Mimetic Gel, Farahnaz Fahimipour, Erfan Dashtimoghadam, Mohammad Mahdi Hasani-Sadrabadi, Jessica Vargas, Daryoosh Vashaee, Doug Lobner, Tahereh S. Jafarzadeh Kashi, Behnam Ghasemzadeh, Lobat Tayebi

Biomedical Sciences Faculty Research and Publications

Objective

Design of bioactive scaffolds with osteogenic capacity is a central challenge in cell-based patient-specific bone tissue engineering. Efficient and spatially uniform seeding of (stem) cells onto such constructs is vital to attain functional tissues. Herein we developed heparin functionalized collagen gels supported by 3D printed bioceramic scaffolds, as bone extracellular matrix (ECM)-mimetic matrices. These matrices were designed to enhance cell seeding efficiency of mesenchymal stem cells (MSCs) as well as improve their osteogenic differentiation through immobilized bone morphogenic protein 2 (BMP2) to be used for personalized bone regeneration.

Methods

A 3D gel based on heparin-conjugated collagen matrix capable of …

The Role Of Movement Pattern In Relation To Running Related Injuries Risk Factors, Marwan Mahmoud A Aljohani

Dissertations (1934 -)

About 52.3 million American run on a regular basis. Up to 79% of runners get injured every year and the rate of injury has not declined over the past decades. Females have twice the risk of developing a running related injury (RRI). Rate of loading (ROL), tibial impact shock (TIS), and low movement variability may contribute to the development of RRI. Not much is known, however, about the relationships between impact kinetics (i.e. ROL, TIS) and movement variability. In addition, there is a lack of understanding about the effects of sex and speed on the aforementioned RRI risk factors. Therefore, …

Testing Allostatic Load Factor Structures Among Adolescents: A Structural Equation Modeling Approach, Amanda L. King, Mauricio Garnier-Villarreal, Amanda M. Simanak, Norah L. Johnson

College of Nursing Faculty Research and Publications

Objectives

Allostatic load (AL) represents cumulative biological “wear and tear” that results from chronic stress exposure over time, ultimately increasing risk for chronic disease. A consensus is lacking regarding the best operationalization of AL, particularly for younger, less studied populations. The purpose of this study was to test multiple hypothesized factor structures for AL to determine the best measurement approach for adolescents.

Methods

We analyzed biologic data for 1900 adolescents aged 12‐18 from four waves (2003‐2010) of the National Health and Nutrition Examination Survey. AL indicator variables included cardiovascular (systolic BP, creatinine), metabolic (HDL, LDL, triglycerides, insulin, fasting glucose, HA1C, …

Urban Partnerships To Address Health Literacy In High Need Populations, Abiola O. Keller, Amy Vuyk, Joshua Knox

College of Nursing Faculty Research and Publications

Low health literacy disproportionately affects racial and ethnic minority communities and lower-income socioeconomic groups. To address this critical determinant of health inequity, two nonprofit organizations, Repairers of the Breach, a day shelter for individuals experiencing homelessness, and Bread of Healing a neighborhood-based clinic serving individuals with low incomes, partnered with researchers at Marquette University to implement and evaluate an evidence-supported health literacy program. The partnership delivered the curriculum in seven one-hour sessions over seven weeks. The program attendees were predominantly African American men and women from 19–73 years old. Most participants had formal education ranging from elementary school to some …

A Concept Analysis Of Parental Uncertainty In Illness Of An Infant, Kathryn J. Malin, Teresa S. Johnson

College of Nursing Faculty Research and Publications

Background:

The concept of uncertainty in illness has been well described and applied to many different areas of nursing and other disciplines. Specifically, parental uncertainty in illness of an infant is a meaningful concept that has specific attributes and implications. A current concept analysis that considers the changing healthcare setting, historical conceptual inconsistencies, and a lack of information concerning parents of infants is needed.

Purpose:

To identify essential antecedents, attributes, and consequences of parental uncertainty in illness using Rodgers' Evolutionary Concept Analysis method.

Methods:

A literature search was conducted using PubMed, CINAHL, and PsycInfo. The following keywords were used in …

The Influence Of Masculinity On Male Latino Adolescents’ Perceptions Regarding Dating Relationships And Dating Violence, Kristin Haglund, Ruth Ann Belknap, Lisa M. Edwards, Marcel Hernani Tassara, James C. Van Hoven, Aimee A. Woda

College of Nursing Faculty Research and Publications

In the United States, teen dating violence (TDV) is a concern across ethnic groups. Attitudes and correlates of violence differ by gender, culture, and acculturation. This study used a qualitative interpretive approach. Data were obtained in focus groups with 23 Latino male adolescents. Themes reflected contexts of participants’ lives, and definitions and nature of dating relationships and TDV. Participants described the importance of respecting dating partners, the destructive effects of TDV, and the pressure to display masculinity that can lead some young men to perpetrate TDV. These results may advance culturally relevant interventions to promote healthy relationships and prevent dating …

Variability In Catheter-Associated Asymptomatic Bacteriuria Rates Among Individual Nurses In Intensive Care Units: An Observational Cross-Sectional Study, Olga Yakusheva, Deena K. Costa, Kathleen L. Bobay, Jorge P. Parada, Marianne E. Weiss

College of Nursing Faculty Research and Publications

Catheter-associated asymptomatic bacteriuria (CAABU) is frequent in intensive care units (ICUs) and contributes to the routine use of antibiotics and to antibiotic-resistant infections. While nurses are responsible for the implementation of CAABU-prevention guidelines, variability in how individual nurses contribute to CAABU-free rates in ICUs has not been previously explored. This study’s objective was to examine the variability in CAABU-free outcomes of individual ICU nurses. This observational cross-sectional study used shift-level nurse-patient data from the electronic health records from two ICUs in a tertiary medical center in the US between July 2015 and June 2016. We included all adult (18+) catheterized …

Moving Nursing Beyond P < .05, Matthew J. Hayat, Vincent S. Staggs, Todd A. Schwartz, Melinda Higgins, Andres Azuero, Chakra Budhathoki, Rameela Chandrasekhar, Paul Cook, Emily Cramer, Mary S. Dietrich, Mauricio Garnier-Villarreal, Alexandra Hanlon, Jinghua He, Jinxiang Hu, Myoung Jin Kim, Martina Mueller, Joseph R. Nolan, Yelena Perkhounkova, Janet Rothers, Glenna Schluck, Xiaogang Su, Thomas N. Templin, Michael T. Weaver, Qing Yang, Sangbeak Ye

College of Nursing Faculty Research and Publications

No abstract provided.

The Use Of Halo Gravity Traction In The Treatment Of Severe Early Onset Spinal Deformity, Sravisht Iyer, Henry Ofori Duah, Irene Wulff, Henry O. Tutu, Rufai Mahmud, Kwadwo P. Yankey, Harry Akoto, Oheneba Boachie-Adjei

College of Nursing Faculty Research and Publications

Study Design. 

Retrospective Review of Prospective cohort.

Objective. 

To describe the feasibility of preoperative halo gravity traction (HGT) with subsequent growing rod/guided growth (GR/GG) placement in early onset spinal deformity (EOSD).

Summary of Background Data. 

In children with severe EOSD, primary implantation of GR/GG constructs is not always possible. We describe a staged protocol with preoperative HGT followed by GR/GG implantation.

Methods. 

EOSD patients treated with HGT prior to GR/GG implantation were included. HGT used traction up to 50% body weight for 4 to 29 weeks. Pulmonary function tests (PFTs) were performed before and after HGT. Coronal Cobb (CC) and …

Effects Of Dental Composite Resin Monomers On Dental Pulp Cells, Thomas R. Schneider, Roxan Hakami-Tafreshi, Alexandra Tomasino-Perez, Lobat Tayebi, Doug Lobner

School of Dentistry Faculty Research and Publications

Methacrylate monomers found in many dental materials cause toxicity to dental pulp cells but the mechanism of the toxicity is poorly understood. We used cultured human dental pulp cells to test the effects of three commonly used monomers; bisphenol-A-glycidyl methacrylate (Bis-GMA), urethane dimethacrylate (UDMA), and triethyleneglycol dimethacrylate (TEGDMA). The order of toxicity was Bis-GMA>UDMA>TEGDMA. The toxicity correlated inversely with cystine uptake, with TEGDMA stimulating uptake and BisGMA and UDMA inhibiting uptake. Bis-GMA and UDMA induced oxidative stress, while TEGDMA did not. Toxicity correlated poorly with glutathione levels, as all compounds decreased cellular glutathione. TEGDMA is less toxic than …

Differential Effects Of Aging And Physical Activity On Corticospinal Excitability Of Upper And Lower Limb Muscles, Vianney Rozand, Jonathon William Senefeld, Christopher W. Sundberg, Ashleigh E. Smith, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Corticospinal tract excitability can be altered by age, physical activity (PA), and possibly sex, but whether these effects differ between upper and lower limb muscles is unknown. We determined the influence of age, PA, and sex on corticospinal excitability of an upper limb and a lower limb muscle during submaximal contractions by comparing stimulus-response curves of motor evoked potentials (MEPs). Transcranial magnetic stimulation (TMS) was used to evoke stimulus-response curves in active muscles by incrementally increasing the stimulator intensity from below the active motor threshold (AMT) until a plateau in MEP amplitudes was achieved. Stimulus-response curves were analyzed from the …

Stimulus-Responsive Polymeric Nanogels As Smart Drug Delivery Systems, Sakineh Hajebi, Navid Rabiee, Mojtaba Bagherzadeh, Sepideh Ahmadi, Mohammad Rabiee, Hossein Roghani-Mamaqani, Mohammadreza Tahriri, Lobat Tayebi, Michael R. Hamblin

School of Dentistry Faculty Research and Publications

Nanogels are three-dimensional nanoscale networks formed by physically or chemically cross-linking polymers. Nanogels have been explored as drug delivery systems due to their advantageous properties, such as biocompatibility, high stability, tunable particle size, drug loading capacity, and possible modification of the surface for active targeting by attaching ligands that recognize cognate receptors on the target cells or tissues. Nanogels can be designed to be stimulus responsive, and react to internal or external stimuli such as pH, temperature, light and redox, thus resulting in the controlled release of loaded drugs. This “smart” targeting ability prevents drug accumulation in non-target tissues and …

Comparison Of Gingival Retraction Materials Using A New Gingival Sulcus Model, Marco Dederichs, Mina D. Fahmy, Harald Kuepper, Arndt Guentsch

School of Dentistry Faculty Research and Publications

Purpose

To investigate the pressure generated by different retraction materials using a novel gingival sulcus model.

Materials and Methods

A gingival sulcus model was made using a polymer frame filled with silicon. A pressure sensor and a sulcus‐fluid simulation were embedded into the silicon chamber to evaluate the pressure generated by different retraction materials. Six sizes of Ultrapak retraction cords (Ultradent, sizes #000 ‐ 3), 4 retraction pastes (Expazen, Expasyl, Acteon, Access Edge, Traxodent) and 2 retraction gels (Sulcus Blue, Racegel) were analyzed. The mean and median pressure, interquartile range, and standard deviation (SD) of n = 10 repeated measurements …

Qualitative Methods Of Road Traffic Crash Research In Low- And Middle-Income Countries: A Review, Benjamin D. Holmes, Kristin Haglund, Kirsten M.M. Beyer, Laura D. Cassidy

College of Nursing Faculty Research and Publications

Road traffic crashes are rapidly becoming one of the leading causes of injury and death globally. It is predicted that by 2030 crashes will become the fourth leading cause of disability-adjusted life years (DALYs) (Mathers & Loncar, [11]) and the seventh leading global cause of death (World Health Organization [WHO], [26]). The global death toll due to crashes has already escalated by 46% over the past two decades (The World Bank, [21]).

Low- and middle-income countries (LMICs) are acutely affected by this 'hidden epidemic' (Balch, [ 1]). Ninety per cent of the world's crash-related deaths occur in LMICs where only …

“I Am A Runner”: A Qualitative Analysis Of Women-Runners’ Pregnancy Experiences, Jennifer M. Ohlendorf, Anna L. Anklam, Lindsay Gardner

College of Nursing Faculty Research and Publications

Background

Women runners are a group with potential for health maintenance and health promotion in pregnancy. When providers counsel women to discontinue or cut back on running without cause, an opportunity for health benefits to both woman and baby may be lost.

Aim

This study aims to explicate the experience women runners have in pregnancy to further providers’ understanding of this population’s unique needs.

Methods

An online, qualitative inquiry was employed to explore the experiences of an online community of women runners in pregnancy (N = 22). The Doing Pregnancy framework provided guidance for final stages of the analysis.

Findings …

Interdisciplinary Collaboration Needed In Obtaining High-Quality Medical Information In Child Abuse Investigations, Elizabeth Cleek, Norah L. Johnson, Lynn K. Sheets

College of Nursing Faculty Research and Publications

Background

Despite reporting legislation, healthcare providers (HCPs) do not always report and collaborate in cases of suspected child abuse. Recognizing this leaves children at risk, the Wisconsin Child Abuse Network (WI CAN) sought to understand barriers to mandated reporting and collaboration with child abuse investigators.

Objective

The purpose of the study was to investigate barriers for professionals in providing and obtaining high-quality medical information in child abuse investigations.

Participants and setting

Participants included five discipline-specific focus groups: HCPs, child protective services (CPS), law enforcement, lawyers, and judges. All professionals had been directly involved in Wisconsin child abuse cases.

Methods

This …

Functional Exercise Improves Mobility Performance In Older Adults With Type 2 Diabetes: A Randomized Controlled Trial, Kimberlee A. Gretebeck, Caroline S. Blaum, Tisha Moore, Roger Brown, Andrzej Galecki, Debra Strasburg, Shu Chen, Neil B. Alexander

College of Nursing Faculty Research and Publications

Background: Diabetes-related disability occurs in approximately two-thirds of older adults with diabetes and is associated with loss of independence, increased health care resource utilization, and sedentary lifestyle. The objective of this randomized controlled trial was to determine the effect of a center-based functional circuit exercise training intervention followed by a 10-week customized home-based program in improving mobility function in sedentary older adults with diabetes.

Methods: Participants (n = 111; mean age 70.5 [7.1] y; mean body mass index 32.7 [5.9] kg/m²) were randomized to either a moderate-intensity functional circuit training (FCT) plus 10-week home program to …

Positions In The N‐Methyl‐D‐Aspartate Receptor Glun2c Subunit M3 And M4 Domains Regulate Alcohol Sensitivity And Receptor Kinetics, Man Wu, Priya Katti, Yulin Zhao, Robert W. Peoples

Biomedical Sciences Faculty Research and Publications

Background

Alcohol alters synaptic transmission in the brain. The N‐methyl‐D‐aspartate (NMDA) receptor (NMDAR), a subtype of glutamate‐gated ion channel, is an important synaptic target of alcohol in the brain. We and others have previously identified 4 alcohol‐sensitive positions in the third and fourth membrane‐associated (M) domains, designated M3_1‐2and M4_1‐2, of the GluN1, GluN2A, and GluN2B NMDAR subunits. In the present study, we tested whether the corresponding positions in the GluN2C subunit also regulate alcohol sensitivity and ion channel gating.

Methods

We performed alanine‐ and tryptophan‐scanning mutagenesis in the GluN2C subunit followed by expression in HEK …

Bicyclic Peptides: Types, Synthesis And Applications, Shahrzad Ahangarzadeh, Mohammad M. Kanafi, Simzar Hosseinzadeh, Ahad Mokhtarzadeh, Mahmood Barati, Javad Ranjbari, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Bicyclic peptides form one of the most promising platforms for drug development owing to their biocompatibility, similarity and chemical diversity to proteins, and they are considered as a possible practical tool in various therapeutic and diagnostic applications. Bicyclic peptides are known to have the capability of being employed as an effective alternative to complex molecules, such as antibodies, or small molecules. This review provides a summary of the recent progress on the types, synthesis and applications of bicyclic peptides. More specifically, natural and synthetic bicyclic peptides are introduced with their different production methods and relevant applications, including drug targeting, imaging …

Testing Measurement Invariance With Ordinal Missing Data: A Comparison Of Estimators And Missing Data Techniques, Po-Yi Chen, Wei Wu, Mauricio Garnier-Villarreal, Benjamin Arthur Kite, Fan Jia

College of Nursing Faculty Research and Publications

Ordinal missing data are common in measurement equivalence/invariance (ME/I) testing studies. However, there is a lack of guidance on the appropriate method to deal with ordinal missing data in ME/I testing. Five methods may be used to deal with ordinal missing data in ME/I testing, including the continuous full information maximum likelihood estimation method (FIML), continuous robust FIML (rFIML), FIML with probit links (pFIML), FIML with logit links (lFIML), and mean and variance adjusted weight least squared estimation method combined with pairwise deletion (WLSMV_PD). The current study evaluates the relative performance of these methods in producing valid chi-square difference tests …