Medicine and Health Sciences Commons^™

Plga-Coated Drug-Loaded Nanotubes Anodically Grown On Nitinol, F. Davoodian, E. Salahinejad, E. Sharifi, Z. Barabadi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

This study evaluates the use of nanotubes (NTs) as a matrix for local drug delivery modified by a biodegradable polymeric coating on medical-grade nitinol (NiTi alloy) surfaces. For this purpose, NiTi was anodized within parameters that promote the formation of NTs, ultrasonicated, annealed and impregnated with vancomycin hydrochloride. To improve bioperformance, poly(lactic-co-glycolic acid) (PLGA) was also deposited on the drug-loaded NTs. The samples were characterized in terms of structure, wettability, drug delivery, corrosion and cytocompatibility. Scanning electron microscopy and water contact angle measurements signify the formation of open-top homogeneous NTs of 600– 700 nm in length and ~30 nm in …

Marking Time: Colorful New Insights Into Master Clock Circuits, Deborah A.M. Joye, Jennifer A. Evans

Biomedical Sciences Faculty Research and Publications

No abstract provided.

A Tri-Component Knee Plug For The 3rd Generation Of Autologous Chondrocyte Implantation, Lobat Tayebi, Zhanfeng Cui, Hua Ye

School of Dentistry Faculty Research and Publications

Here, we report a newly designed knee plug to be used in the 3rd generation of Autologous Chondrocyte Implantation (ACI) in order to heal the damaged knee cartilage. It is composed of three components: The first component (Bone Portion) is a 3D printed hard scaffold with large pores (~ 850 µm), made by hydroxyapatite and β-tricalcium phosphate to accommodate the bony parts underneath the knee cartilage. It is a cylinder with a diameter of 20 mm and height of 7.5 mm, with a slight dome shape on top. The plug also comprises a Cartilage Portion (component 2) which is a …

The Influence Of Autonomic Function On Pain Modulation Before And After Exercise And Cognitive Task In Fibromyalgia, Abdulaziz Awali

Dissertations (1934 -)

Fibromyalgia (FM) is a chronic pain condition characterized by widespread pain. People with FM have alterations in autonomic function compared to healthy individuals. Exercise can decrease pain in people with FM, however some people with FM experience pain exacerbation when initiating exercise. Whether variability in pain at rest and following exercise is related to altered autonomic function, including the potential implications with other stressful events such as mental math, is not known. This dissertation aimed at investigating: 1) the relation between cardiovascular autonomic function and central pain facilitation and inhibition, measured by temporal summation of pain (TS) and conditioned pain …

A Discrete-Choice Experiment To Assess Patients’ Preferences For Osteoarthritis Treatment: An Esceo Working Group, Mickael Hiligsmann, Elaine Dennison, Charlotte Beaudart, Gabriel Herrero-Beaumont, Jaime Branco, Olivier Bruyère, Philip G. Conaghan, Cyrus Cooper, Nasser Al-Daghri, Famida Jiwa, Willem Lems, Daniel Pinto, René Rizzoli, Thierry Thomas, Daniel Uebelhart, Nicolas Veronese, Jean-Yves Reginster

Physical Therapy Faculty Research and Publications

Objective

To evaluate the preferences of patients with osteoarthritis for treatment.

Methods

A discrete-choice experiment was conducted among adult OA patients who were presented with 12 choice sets of two treatment options and asked in each to select the treatment they would prefer. Based on literature reviews, expert consultation, patient survey and expert meeting, treatment options were characterized by seven attributes: improvement in pain, improvement in walking, ability to manage domestic activities, ability to manage social activities, improvement in overall energy and well-being, risk of moderate/severe side effects and impact on disease progression. Random parameters logit model was used to …

Pain Modulatory Effects Of Exercise In Chronic Pain, Giovanni Berardi

Dissertations (1934 -)

Exercise training is recommended as a first-line treatment in the management of fibromyalgia due to its ability to improve symptoms and function. However, many with fibromyalgia report limited tolerance to exercise due to exacerbation of pain and fatigue during and following participation of a single bout of exercise. The purpose of this dissertation was to determine the influence of contraction type on local and systemic experimental pain sensitivity, performance fatigue, and perceived pain and fatigue during exercise and through recovery in people with and without fibromyalgia.Experimental and perceived pain were measured before and after a single bout of submaximal intermittent …

Experimental & Simulation Approaches To Study Neuromuscular Control In People With Chronic Ankle Instability, Hoon Kim

Dissertations (1934 -)

Ankle sprains are among the most common musculoskeletal injuries, and up to 70% of people who sprain their ankles develop chronic ankle instability (CAI). Moreover, people who develop CAI have a significantly higher risk of developing ankle osteoarthritis. Recent research has identified neuromuscular deficits that may be responsible for the high recurrence rates of ankle sprains and for the progression towards ankle osteoarthritis in people with CAI. Unfortunately, current rehabilitation strategies are not completely successful because the mechanisms responsible for these deficits are not fully elucidated. Therefore, the purpose of this dissertation was to investigate individual muscle forces and force …

Adolescents And Young Adults With Cancer Using A Symptom Heuristics App: Provider Perceptions And Actions, Catherine Fiona Macpherson, Kristin Stegenga, Jeanne Erickson, Lauri Linder, Amy Rose Newman, Ronald K. Elswick, John Charlson, Stefanie Thomas, Suzanne Ameringer

College of Nursing Faculty Research and Publications

Purpose: This study examined health care providers' perceptions of the usefulness and ease of use of a symptom heuristics app delivered via a tablet computer as a resource for understanding symptom experiences of adolescents and young adults (AYAs) with cancer. AYAs' app-generated symptom reports were compared with providers' documentation of AYAs' symptoms.

Methods: This multisite study included responses from 86 AYAs 15–29 years of age who completed the Computerized Symptom Capture Tool (C-SCAT) before two scheduled visits for chemotherapy. After each visit, their providers completed a survey addressing their perspective of: (1) the usefulness of data provided by the C-SCAT …

Who Is Wearing A Mask? Gender-, Age-, And Location-Related Differences During The Covid-19 Pandemic, Mike Haischer, Rachel Beilfuss, Meggie Rose Hart, Lauren Opielinski, David Wrucke, Gretchen Zirgaitis, Toni D. Urich, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Masks are an effective tool in combatting the spread of COVID-19, but some people still resist wearing them and mask-wearing behavior has not been experimentally studied in the United States. To understand the demographics of mask wearers and resistors, and the impact of mandates on mask-wearing behavior, we observed shoppers (n = 9935) entering retail stores during periods of June, July, and August 2020. Approximately 41% of the June sample wore a mask. At that time, the odds of an individual wearing a mask increased significantly with age and was also 1.5x greater for females than males. Additionally, the …

Exercise And Lifestyle Physical Activity Recommendations For People With Multiple Sclerosis Throughout The Disease Course, Rosalind Kalb, Theodore R. Brown, Susan Coote, Kathleen Costello, Ulrik Dalgas, Eric Garmon, Barbara Geisser, June Halper, Herb Karpatkin, Jennifer Keller, Alexander V. Ng, Lara A. Pilutti, Amanda Rohring, Paul Van Asch, Kathleen Zachowski, Robert W. Motl

Exercise Science Faculty Research and Publications

Objectives:

To provide clinicians who treat multiple sclerosis (MS) patients with evidence-based or expert opinion–based recommendations for promoting exercise and lifestyle physical activity across disability levels.

Methods:

The National MS Society (“Society”) convened clinical and research experts in the fields of MS, exercise, rehabilitation, and physical activity to (1) reach consensus on optimal exercise and lifestyle physical activity recommendations for individuals with MS at disability levels 0–9.0 on the Expanded Disability Status Scale (EDSS) and (2) identify and address barriers/facilitators for participation.

Recommendations:

Based on current evidence and expert opinion, the Society makes the following recommendations, endorsed by the Consortium …

Impaired Firing Behavior Of Individually Tracked Paretic Motor Units During Fatiguing Contractions Of The Dorsiflexors And Functional Implications Post Stroke, Francesco Negro, Kathleen Bathon, Jennifer Nguyen, Cassidy Bannon, Claudio Orizio, Sandra K. Hunter, Allison S. Hyngstrom

Exercise Science Faculty Research and Publications

Introduction: This study quantified stroke-related changes in the following: (1) the averaged discharge rate of motor units (individually tracked and untracked) identified from high-density electromyography (HD-EMG) recordings, (2) global muscle EMG properties of the dorsiflexors during a fatiguing contraction, and the relationship between task endurance and measures of leg function.

Methods: Ten individuals with chronic stroke performed a sustained sub-maximal, isometric, fatiguing dorsiflexion contraction in paretic and non-paretic legs. Motor-unit firing behavior, task duration, maximal voluntary contraction strength (MVC), and clinical measures of leg function were obtained.

Results: Compared to the non-paretic leg, the paretic leg task duration was shorter, …

Time-Frequency Analysis Of Muscle Activation Patterns In People With Chronic Ankle Instability During Landing And Cutting Tasks, Hoon Kim, Rianna M. Palmieri-Smith, Kristof Kipp

Exercise Science Faculty Research and Publications

Background

People with chronic ankle instability (CAI) exhibit neuromuscular deficits. Previous studies, however, only investigated magnitudes of muscle activation and not the time-frequency domain.

Research question

Do people with CAI exhibit differences in muscle activation patterns in the time-frequency domain during landing, anticipated cutting, and unanticipated cutting compared to matched controls?

Methods

Eleven people with CAI and eleven healthy matched controls (CON) performed landing, anticipated cutting, and unanticipated cutting as surface EMG of the lateral gastrocnemius, medial gastrocnemius, fibularis longus, soleus, and tibialis anterior were recorded. The time-frequency domain of surface EMG data was analyzed with wavelet transformations and principal …

Greater Fatigue Resistance Of Dorsiflexor Muscles In People With Prediabetes Than Type 2 Diabetes, Jonathon Senefeld, Lynette A. Singh-Peters, Kenji A. Kenno, Sandra K. Hunter, Jennifer M. Jakobi

Exercise Science Faculty Research and Publications

Although exercise can prevent progression to T2D among people with prediabetes, little is known about fatigue during exercise in people with prediabetes compared to T2D. The purpose of the study was to compare the magnitude and mechanisms of fatigability of the ankle dorsiflexor muscles between people with prediabetes and T2D. Ten people with prediabetes (6 females, 51.7 ± 6.9 years) and fourteen with T2D (6 females, 52.6 ± 6.2 years) who were matched for age, body mass index and physical activity performed an intermittent (6 s contraction: 4 s relaxation) fatiguing task at 75% maximal voluntary contraction (MVC) with the …

Bonding Crowns And Bridges With Resin Cement, Nathaniel C. Lawson, Sharukh Khajotia, Ana K. Bedran-Russo, Kevin Frazier, Jacob Park, Ariene A. Leme-Kraus, Olivia Urquhart

School of Dentistry Faculty Research and Publications

Background

Bonding crowns and bridges with resin cement can improve retention and reinforcement of the restoration. However, there is variation in the steps taken by different practitioners to achieve this goal.

Methods

The authors developed a survey on bonding dental crowns and bridges with resin cement and distributed it electronically to the American Dental Association Clinical Evaluators (ACE) Panel on May 22, 2020. The survey remained open for 2 weeks. Descriptive data analysis was conducted using SAS Version 9.4.

Results

A total of 326 panelists responded to the survey, and 86% of respondents who place crowns or bridges use resin …

Removal Of Water Binding Proteins From Dentin Increases The Adhesion Strength Of Low-Hydrophilicity Dental Resins, Ana Paula Farina, Doglas Cecchin, Cristina M. P. Vidal, Ariene A. Leme-Kraus, Ana K. Bedran-Russo

School of Dentistry Faculty Research and Publications

Objectives

To investigate the role of proteoglycans (PGs) on the physical properties of the dentin matrix and the bond strength of methacrylate resins with varying hydrophilicities.

Methods

Dentin were obtained from crowns of human molars. Enzymatic removal of PGs followed a standard protocol using 1 mg/mL trypsin (Try) for 24 h. Controls were incubated in ammonium bicarbonate buffer. Removal of PGs was assessed by visualization of glycosaminoglycan chains (GAGs) in dentin under transmission electron microscopy (TEM). The dentin matrix swelling ratio was estimated using fully demineralized dentin. Dentin wettability was assessed on wet, dry and re-wetted dentin surfaces through water …

Fibroblast Encapsulation In Gelatin Methacryloyl (Gelma) Versus Collagen Hydrogel As Substrates For Oral Mucosa Tissue Engineering, Fahimeh Tabatabaei, Keyvan Moharamzadeh, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Purpose

Over the past decades, a variety of biomaterials have been investigated in terms of their suitability for oral mucosa tissue engineering. The aim of this study was to compare collagen and GelMA hydrogels as connective tissue scaffolds for fibroblasts and as substrates for seeding and culture of oral epithelial keratinocyte cells.

Methods

Human primary oral fibroblast and keratinocyte cells were isolated from gingival biopsies. The mixture of fibroblasts with GelMA or collagen gel were aliquoted within six-well tissue culture plate inserts and cross-linked using visible light or reconstitution buffer/heat, respectively. The viability of fibroblasts in the hydrogels was investigated …

Sublingual Emphysema Following Alveoloplasty: A Case Report, Austin Dodge, Katelyn Kreh, Vrisiis Kofina, Swati Y. Rawal

School of Dentistry Faculty Research and Publications

Various cases of introduction of air into soft tissues have been reported in the dental literature. Here, we report a rare case of localized sublingual emphysema after alveoloplasty. There was no facial involvement. The patient responded to treatment and recovered uneventfully.

Carbosilane Dendrimers: Drug And Gene Delivery Applications, Navid Rabiee, Shokooh Ahmadvand, Sepideh Ahmadi, Yousef Fatahi, Rassoul Dinarvand, Mojtaba Bagherzadeh, Mohammad Rabiee, Mohammadreza Tahriri, Lobat Tayebi, Michael R. Hamblin

School of Dentistry Faculty Research and Publications

Carbosilane dendrimers are a particular type of dendrimer structure that has been used as delivery vehicles for drugs and nucleic acids. They have a defined structure according to their generation number, and their terminal groups can be rendered cationic or anionic. The cationic charges can address the limitation of electrostatic repulsion between the negatively charged phosphate groups of nucleic acids and negatively charged cell membranes. Specific drugs can be loaded into the central part of the dendrimer or attached at the exterior, and the overall positive charge may improve the efficacy of anti-inflammatory drugs. One promising feature of dendrimers is …

Three-Dimensional In Vitro Oral Mucosa Models Of Fungal And Bacterial Infections, Fahimeh Tabatabaei, Keyvan Moharamzadeh, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Oral mucosa is the target tissue for many microorganisms involved in periodontitis and other infectious diseases affecting the oral cavity. Three-dimensional (3D) in vitro and ex vivo oral mucosa equivalents have been used for oral disease modeling and investigation of the mechanisms of oral bacterial and fungal infections. This review was conducted to analyze different studies using 3D oral mucosa models for the evaluation of the interactions of different microorganisms with oral mucosa. In this study, based on our inclusion criteria, 43 articles were selected and analyzed. Different types of 3D oral mucosa models of bacterial and fungal infections were …

Aptamer-Conjugated Plga Nanoparticles For Delivery And Imaging Of Cancer Therapeutic Drugs, Maryam Hashemi, Azarmidokht Shamshiri, Majid Saeedi, Lobat Tayebi, Rezvan Yazdian-Robati

School of Dentistry Faculty Research and Publications

Most problems associated with chemotherapeutic agents involve non-specific cytotoxicity, low intratumoral accumulation and drug resistance. Targeted drug delivery systems (TDDS) based on nanoparticles (NPs) are a new strategy for better therapeutic efficiency, along with reduction of side effects commonly seen with cancer drugs. Poly (lactic-co-glycolic acid) (PLGA), as one of the furthest developed synthetic polymer, has gained significant attention because of excellent properties—including biodegradability and biocompatibility, controlled release of drug, protection of drug or gene from decomposition and ability to modify surface with targeting agents for both cancer diagnosis and therapy. Aptamers are single-stranded RNA or DNA that can fold …

Shedding Light On The Role Of Keratinocyte-Derived Extracellular Vesicles On Skin-Homing Cells, Golara Nasiri, Negar Azarpira, Aliakbar Alizadeh, Sanaz Goshtasbi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Extracellular vesicles (EVs) are secretory lipid membranes with the ability to regulate cellular functions by exchanging biological components between different cells. Resident skin cells such as keratinocytes, fibroblasts, melanocytes, and inflammatory cells can secrete different types of EVs depending on their biological state. These vesicles can influence the physiological properties and pathological processes of skin, such as pigmentation, cutaneous immunity, and wound healing. Since keratinocytes constitute the majority of skin cells, secreted EVs from these cells may alter the pathophysiological behavior of other skin cells. This paper reviews the contents of keratinocyte-derived EVs and their impact on fibroblasts, melanocytes, and …

A Review On The Biodistribution, Pharmacokinetics And Toxicity Of Bismuth-Based Nanomaterials, Samireh Badrigilan, Fatemeh Heydarpanahi, Jalal Choupani, Mehdi Jaymand, Hadi Samadian, Mojtaba Hoseini-Ghahfarokhi, Thomas J. Webster, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Here, bismuth-based nanomaterials (Bi-based NMs) are introduced as promising theranostic agents to enhance image contrast as well as for the therapeutic gain for numerous diseases. However, understanding the interaction of such novel developed nanoparticles (NPs) within a biological environment is a requisite for the translation of any promising agent from the lab bench to the clinic. This interaction delineates the fate of NPs after circulation in the body. In an ideal setting, a nano-based therapeutic agent should be eliminated via the renal clearance pathway, meanwhile it should have specific targeting to a diseased organ to reach an effective dose and …

Direct Healthcare Costs Associated With Oligoarticular Juvenile Idiopathic Arthritis At A Single Center, Amit Thakral, Daniel Pinto, Michael Miller, Megan L. Curran, Marisa Klein-Gitelman, Dustin D. French

Physical Therapy Faculty Research and Publications

Oligoarticular juvenile idiopathic arthritis (JIA) is a common disease in pediatric rheumatology. The management of oligoarticular JIA can result in a considerable economic burden. This study is a four-year, retrospective cost identification analysis performed to determine the annual direct cost of care for patients with oligoarticular JIA and possible predictive clinical factors. Direct healthcare costs were defined as those associated with office visits, laboratory studies, hospital admissions, joint injections, medications, infusions, radiology tests, and emergency room visits. Disease characteristics and patient information included ANA status, gender, age at diagnosis, duration from diagnosis to initial visit during the study period, and …

Magnetic Dual-Template Molecularly Imprinted Polymer Based On Syringe-To-Syringe Magnetic Solid-Phase Microextraction For Selective Enrichment Of P-Coumaric Acid And Ferulic Acid From Pomegranate, Grape, And Orange Samples, Ebrahim Alipanahpour Dil, Mehrorang Ghaedi, Arash Asfaram, Fatemah Mehrabi, Ardeshir Shokrollahi, Amir Abbas Matin, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Magnetic dual-template molecularly imprinted polymer (Fe₃O₄@SiO₂-MDMIP) was prepared to enrich and determine both p-Coumaric acid (p-CA) and ferulic acid (FA) based on syringe-to-syringe magnetic solid-phase microextraction (SS-MSPME). The obtained MDMIP was characterized and recognized, and then its adsorbing performance was studied. Based on the results, the Fe₃O₄@SiO₂-MDMIP indicated selective recognition towards p-CA and FA with large adsorption capacity. The optimization of MDMIP–SS-MSPME conditions (pH, Fe₃O₄@SiO₂-MDMIP mass, NaCl concentration, number of cycle, and elution volume) were conducted using the central composite design (CCD). …

Engaging Parents In Education For Discharge (EPed): Evaluating The Reach, Adoption & Implementation Of An Innovative Discharge Teaching Method, Norah L. Johnson, Stacee M. Lerret, Carol Klingbeil, Michele Polfuss, Cori A. Gibson, Karen Gralton, Mauricio Garnier-Villarreal, Sheikh Iqbal Ahamed, Riddhiman Adib, Rachel Unteutsch, Louis Pawela, Rosemary White-Traut, Kathleen J. Sawin, Marianne E. Weiss

College of Nursing Faculty Research and Publications

Purpose

This paper describes the evaluation of the implementation of an innovative teaching method, the “Engaging Parents in Education for Discharge” (ePED) iPad application (app), at a pediatric hospital.

Design and methods

The Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework was used to guide the evaluation. Three of the five RE-AIM elements are addressed in this study: Reach, Adoption, and Implementation.

Results

The Reach of the ePED was 245 of 1015 (24.2%) patient discharges. The Adoption rate was 211 of 245 (86%) patients discharged in the five months' study period. High levels of fidelity (89.3%) to …

Conversations With Health Care Providers And Parents Before Autism Diagnosis: A Qualitative Study, Norah L. Johnson, Wendy Krueger, Elizabeth Jilek, Kristin Haglund

College of Nursing Faculty Research and Publications

Introduction

The purpose of this study was to explore communication with health care providers from the perceptions of parents before their child's diagnosis of autism spectrum disorder and provide some examples of how communication may contribute to the autism diagnosis.

Method

This study used a qualitative descriptive design with multiple individual structured in-person interviews.

Results

Three themes captured parents’ (n = 8) descriptions of the phases of communication during their children's diagnoses including, (1) anguished questioning, (2) urgently seeking help, and (3) expecting a diagnosis. In addition, three themes characterized the communication style that parents needed, although not always …

“No One Could Calm Him Down”: Mothers’ Experience Of Autism Diagnosis And Obtainment Of Resources In An Urban Public School District, Norah L. Johnson, Phonethip Sangasy, Karen Marie Robinson

College of Nursing Faculty Research and Publications

The purpose of this study was to explore the experience of accessing autism diagnosis and resources in a Midwest urban public school district for diverse mothers of children with autism spectrum disorder. Method: We employed thematic analysis using narrative inquiry methodology to analyze the data from 9 mothers (n = 5 African American, n = 2 Hispanic, and n = 2 White) who participated in a focus group. Results: Three themes were identified by the researchers: (a) late medical diagnosis (subthemes: problems that parents didn’t perceive as signs of autism spectrum disorder, making comparisons to other siblings or children), …

Evaluation Of Mechanical And Biocompatibility Properties Of Hydroxyapatite/Manganese Dioxide Nanocomposite Scaffolds For Bone Tissue Engineering Application, Fatemeh Azizi, Fatemeh Heidari, Farahnaz Fahimipour, Mohammad Sajjadnejad, Daryoosh Vashaee, Lobat Tayebi

School of Dentistry Faculty Research and Publications

The aim of this research was to evaluate the mechanical properties, biocompatibility, and degradation behavior of scaffolds made of pure hydroxyapatite (HA) and HA‐modified by MnO₂ for bone tissue engineering applications. HA and MnO₂ were developed using sol‐gel and precipitation methods, respectively. The scaffolds properties were characterized using X‐ray diffraction (XRD), Fourier transform spectroscopy (FTIR), scanning electron microcopy (SEM), energy dispersive spectroscopy (EDS), and transmission electron microscopy (TEM). The interaction of scaffold with cells was assessed using in vitro cell proliferation and alkaline phosphatase (ALP) assays. The obtained results indicate that the HA/ MnO₂ scaffolds possess higher …

Neurotoxicity Of Isomers Of The Environmental Toxin L-Bmaa, Thomas Schneider, Catherine Simpson, Prachi Desai, Madeleine Tucker, Doug Lobner

Biomedical Sciences Faculty Research and Publications

There is evidence that the environmental toxin β-N-methylamino-L-alanine (L-BMAA) may be involved in neurodegenerative diseases. However, a number of controversies exist regarding L-BMAA, one of which is the possibility that when assaying for L-BMAA, its isomers are being detected instead. There are at least four isomers of BMAA that are known to occur: L-BMAA, β-N-methylamino-D-alanine (D-BMAA), 2,4-diaminobutyric acid (DAB), and N-(2-aminoethyl)glycine (AEG). The fact that isomers of BMAA exist in nature also leads to the possibility that they are involved in toxicity. We set out to determine both the potency and the mechanism of toxicity of L-BMAA, D-BMAA, DAB, and …

Biomineralization, Strength And Cytocompatibility Improvement Of Bredigite Scaffolds Through Doping/Coating, R. Keihan, A. R. Ghorbani, E. Salahinejad, E. Sharifi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Coprecipitation-derived, sacrificial polymeric (urethane) foam-fabricated bredigite (Ca₇MgSi₄O₁₆) scaffolds were processed by individual and combined treatments of fluoride doping and poly (lactic-co-glycolic acid) (PLGA) coating and then studied in terms of structure, mechanical strength, bioactivity and cell biocompatibility in vitro. According to scanning electron microscopy and Archimedes porosimetry, the geometrical characteristics of pores for all the scaffolds are in the appropriate range for hard tissue regeneration applications. The apatite-formation ability of the samples immersed in a simulated body fluid is improved by doping for both the bare and coated conditions, based on …