Medicine and Health Sciences Commons^™

Frontal-Cerebellar Eeg As An Index Of Risk For Alzheimer's Disease In Healthy Elders, Elizabeth Paitel

Dissertations (1934 -)

The Apolipoprotein-E (APOE) ε4 allele is the greatest genetic risk factor for late-onset Alzheimer’s disease (AD), but alone it is not sufficiently predictive. Because neuropathological changes associated with AD begin decades before cognitive symptoms, neuroimaging of healthy, cognitively intact ε4 carriers (ε4+) may enable early characterization of neural patterns associated with risk for future cognitive decline. Research has typically focused on the cerebral cortex, where elders and ε4+ tend to exhibit ‘recruitment’ (i.e., hyperactivation) to maintain cognitive functioning. Yet, recent evidence suggests that AD-related changes may occur even earlier in the cerebellum. Moreover, advances in electroencephalography (EEG) source localization now …

Post-Surgical Emergency After-Hours Calls: Prevalence, Concerns, And Management, Vrisiis Kofina, Drake Lindholm, Abdulkareem Harunani, Andrew R. Dentino, Maharaj Singh, Dimitris N. Tatakis

College of Nursing Faculty Research and Publications

Objective

The purpose of this study was to investigate the prevalence, nature, and management of post-surgical emergency after-hours calls in a dental school setting with predoctoral students, graduate students/residents, and faculty providers.

Methods

A patient chart review (March 2018–February 2020) for post-surgical calls through the emergency after-hours pager system was conducted at the Marquette University School of Dentistry. The total number of surgical procedures, procedure type, the timing of call, operator experience, concern, and recommendation given during the call were documented.

Results

During the review period, 83 calls (from 75 patients) were recorded after 8,487 surgical procedures (1% of procedures). …

Inequalities In The Prevalence Of Full Immunization Coverage Among One-Year-Olds In Ghana, 1993–2014, Eugene Budu, Bright Opoku Ahinkorah, Joshua Okyere, Abdul-Aziz Seidu, Henry Ofori Duah

College of Nursing Faculty Research and Publications

Background

We examined the inequalities in the prevalence of full immunization coverage among one-year-olds in Ghana using nationally representative data from the 1993-2014 Ghana Demographic and Health Surveys (GDHSs).

Methods

Using the World Health Organization’s (WHO) Health Equity Assessment Toolkit (HEAT) software, data from the 1993–2014 GDHSs were analyzed. We disaggregated full immunization by five equity stratifiers: wealth quintile, education, sex, residence, and region. Second, we measured the inequality through summary measures, namely Difference, Population Attributable Risk, Ratio, and Population Attributable Fraction. Statistical significance was pegged at 95% Uncertainty Interval.

Results

From 1993 to 2014, full immunization was higher among …

Identifying Gait Pathology After Acl Reconstruction Using Temporal Characteristics Of Kinetics And Electromyography, Naoaki Ito, Jacob J. Capin, Ashutosh Khandha, Thomas S. Buchanan, Lynn Snyder-Mackler

Physical Therapy Faculty Research and Publications

Purpose

Asymmetrical gait mechanics after anterior cruciate ligament reconstruction (ACLR) are associated with the development of posttraumatic knee osteoarthritis. Current measures of gait mechanics have focused heavily on peak magnitudes of knee kinematics, kinetics, and joint contact forces but have seldom considered the rate of knee loading, cumulative knee load, or the timing of motor input surrounding peaks. The purpose of this study was to introduce and describe novel metrics of gait using temporal characteristics of kinetics and EMG to identify neuromuscular deficits of the quadriceps in patients after ACLR.

Methods

Gait mechanics were assessed 6 months (n = …

Total Knee Arthroplasty Assessments Should Include Strength And Performance-Based Functional Tests To Complement Range-Of-Motion And Patient-Reported Outcome Measures, Jacob J. Capin, Michael J. Bade, Jason M. Jennings, Lynn Snyder-Mackler, Jennifer E. Stevens-Lapsley

Physical Therapy Faculty Research and Publications

Range of motion (ROM) and pain often define successful recovery after total knee arthroplasty (TKA), but these routine clinical outcomes correlate poorly or not at all to functional capacity after TKA. The purpose of this Perspective is to underscore the importance of muscle strength and performance-based functional tests in addition to knee ROM and patient-reported outcome (PRO) measures to evaluate outcomes after TKA. Specifically: (1) muscle strength is the rate-limiting step for recovery of function after TKA; (2) progressive rehabilitation targeting early quadriceps muscle strengthening improves outcomes and does not compromise ROM after TKA; (3) ROM and PROs fail to …

Inequalities In Antenatal Care In Ghana, 1998–2014, Abdul-Aziz Seidu, Joshua Okyere, Eugene Budu, Henry Ofori Duah, Bright Opoku Ahinkorah

College of Nursing Faculty Research and Publications

Background

In order to effectively and efficiently reduce maternal mortality and ensure optimal outcomes of pregnancy, equity is required in availability and provision of antenatal care. Thus, analysis of trends of socio-economic, demographic, cultural and geographical inequities is imperative to provide a holistic explanation for differences in availability, quality and utilization of antenatal care. We, therefore, investigated the trends in inequalities  in four or more antenatal care visits in Ghana, from 1998 to 2014.

Methods

We used the World Health Organization’s (WHO) Health Equity Assessment Toolkit (HEAT) software to analyse data from the 1998 to 2014 Ghana Demographic and Health …

Safe Traffic Behaviors In Adolescents: A Cross-Sectional Study Based On The Theory Of Planned Behavior, Alireza Shahab Jahanlou, Laleh Hassani, Vahid Ranaei, Ghodratollah Roshanaei, Sonja Forward, Kristin Haglund, Forouzan Rezapur Shahkolaei

College of Nursing Faculty Research and Publications

Adolescents do not have adequate safe traffic behaviors. This cross-sectional study investigated safe traffic behaviors of 414 male high school students of Hamadan, Iran, randomly selected using the multistage sampling method in 2020. This study used a researcher-made questionnaire based on the theory of planned behavior about safe traffic behaviors with Cronbach’s alpha coefficient of 0.95, content validity ratio of 0.70, and content validity index of 0.85. There was a strong positive correlation between safe traffic behaviors with perceived behavioral control and intention. Adolescents can be influenced to internalize behavioral safety precursors that can lead to a sustained increase in …

Parent Health-Related Quality Of Life For Infants With Congenital Anomalies Receiving Neonatal Intensive Care, Krishna Acharya, Erin Rholl, Kathryn J. Malin, Margaret Malnory, Jonathan Leuthner, Steven R. Leuthner, Joanne Lagatta

College of Nursing Faculty Research and Publications

Objective

To examine factors associated with parent quality of life during and after neonatal intensive care unit (NICU) discharge among parents of infants with congenital anomalies admitted to the NICU.

Study design

This secondary analysis of 2 prospective cohort studies between 2016 and 2020 at a level IV NICU included parents of infants with major congenital anomalies receiving NICU care. The primary outcomes were parent health-related quality of life (HRQL) during the NICU stay and at 3 months post-NICU discharge.

Results

A total of 166 parent–infant dyads were enrolled in the study, 124 of which completed the 3-month follow-up interview. …

Neoadjuvant Chemotherapy Is Associated With Improved Outcomes In Patients With Stage 1a And 1b Pancreatic Cancer Undergoing Surgery: An Ncdb Study, Noah Rozich, Maharaj Singh, Isaac Kriley, James L. Weese, Aaron Chevinsky, Wesley A. Papenfuss, Geoffrey Bellini

College of Nursing Faculty Research and Publications

Background: The use of neoadjuvant chemotherapy (NAC) for pancreatic ductal adenocarcinoma (PDAC) has shown clear advantages in locally advanced and borderline resectable disease. The benefit in upfront resectable PDAC is debated. Moreover, in early clinical stages IA/IB, potential benefits including improved R0 resection rate, decreased tumor upstaging, and survival, are not clear. We hypothesize that NAC will be associated with improved outcomes and survival compared to adjuvant therapy in patients with clinical stage IA/IB PDAC. Methods: The National Cancer Database (NCDB) PUFs (2004-2017) were used to perform a retrospective review of patients with clinical stage IA or IB PDAC undergoing …

Developing Situation Awareness In Simulation Prebriefing, Amanda L. Potter, Kristina Dreifuerst, Aimee A. Woda

College of Nursing Faculty Research and Publications

BACKGROUND:

Prebriefing before simulation is a recommended practice that increases learner satisfaction and improves performance. Promoting situation awareness through prebriefing facilitates optimal learning outcomes.

METHOD:

Endsley's Model of Situation Awareness is applied to the cognitive work of nursing practice that occurs during the prebriefing phase of simulation. Perceiving, comprehending, and projecting about elements of a situation lead to clinical judgement, reasoning, decision making, and ultimately nursing actions.

RESULTS:

Developing situation awareness in prebriefing is a supported process that connects learners' prior knowledge and experience with the needed knowledge, skills, and abilities in the simulation environment. These mental models become the …

Emollients To Prevent Eczema In High-Risk Infants: An Integrative Review, Julie Armstrong, Nicole K. Rosinski, Alissa V. Fial, Selorm Ansah, Kristin Haglund

Library Faculty Research and Publications

The purpose of this integrative review was to assess the research on topical emollients to prevent atopic dermatitis (AD) also known as eczema, in infants at high risk for this condition. Atopic dermatitis is a common chronic inflammatory skin disorder. Skin barrier dysfunction plays a prominent role in its development. Topical emollients have been hypothesized to enhance the skin barrier and prevent AD.

Methods:

Searches were conducted in September 2021 in PubMed, CINAHL, Cochrane Library, and Web of Science using key word search terms dermatitis, atopic, emollients, petrolatum, and infant, newborn. Inclusion criteria were articles written in English …

Childhood Obesity Within The Lens Of Racism, Nancy T. Browne, Eric A. Hodges, Leigh Small, Julia A. Snethen, Marilyn Frenn, Sharon Y. Irving, Bonnie Gance-Cleveland, Cindy Smith Greenberg

College of Nursing Faculty Research and Publications

Despite decades of research and a multitude of prevention and treatment efforts, childhood obesity in the United States continues to affect nearly 1 in 5 (19.3%) children, with significantly higher rates among Black, Indigenous, and People of Colour communities. This narrative review presents social foundations of structural racism that exacerbate inequity and disparity in the context of childhood obesity. The National Institute of Minority Health and Health Disparities' Research Framework guides the explication of structurally racist mechanisms that influence health disparities and contribute to childhood obesity: biologic and genetic, health behaviours, chronic toxic stress, the built environment, race and cultural …

Engagement Of Families In The Care Of Hospitalized Pediatric Patients: A Scoping Review, Teresa Jerofke-Owen, Natalie S. Mcandrew, Karen Gralton, Joan P. Totka, Marianne E. Weiss, Alissa V. Fial, Kathleen J. Sawin

College of Nursing Faculty Research and Publications

This scoping review was conducted to examine the range, nature, and extent of the published family engagement literature specific to the pediatric acute care setting to highlight future research and practice development opportunities. Included studies (N = 247) revealed global relevance. Engagement strategies ranged from more passive such as allowing/encouraging families to be present at the bedside to more active strategies aimed at promoting mutual and reciprocal nurse–patient interactions. Family engagement is distinguished by a mutually beneficial partnership of families with health care team members and care organizations. Future research in the area of family engagement in pediatric nursing …

Beliefs About Safe Traffic Behaviors Among Male High School Students In Hamadan, Iran: A Qualitative Study Based On The Theory Of Planned Behavior, Vahid Ranaei, Alireza Sahab Jahanlu, Laleh Hassani, Ghodratollah Roshanaei, Kristin Haglund, Jagnoor Jagnoor, Forouzan Rezapur Shahkolaei

College of Nursing Faculty Research and Publications

Road traffic injuries are public health challenges with heavy economic and social burdens. Road traffic injuries are common in developing countries and occur disproportionately with adolescents. This study aimed to elicit beliefs about traffic behaviors based on the theory of planned behavior among male high school students in Hamadan, Iran. We used a constructivist-interpretive qualitative design with directional content analysis. Interviews were conducted with 19 adolescent males in Hamadan, Iran. Analysis revealed that theory of planned behavior fit well to explain how perceptions, attitudes, and beliefs influenced traffic behaviors. Perceived subjective norms in the forms of parental encouragement, traffic rules …

More Than A Meme: The Dunning-Kruger Effect As An Opportunity For Positive Change In Nursing Education, Cynthia Sherraden Bradley, Kristina Dreifuerst, Brandon Kyle Johnson, Ann Loomis

College of Nursing Faculty Research and Publications

The Dunning–Kruger Effect (DKE) describes the cognitive bias in which novices tend to overestimate performance or competence while experts tend to underestimate. Those who are lacking in competence do not have the skills to accurately recognize deficient performance. Subjective assessment is used widely in simulation learning and in nursing curricula, yet often without expert feedback and reflective discussions, which can result in mistakes being overlooked and encoded, which could subsequently result in clinical errors. The prevalence of DKE should not be interpreted solely as a deprecation of the use of subjective measures, but rather as an indicator of the need …

Economic Impression Of On-Farm Research For Sustainable Crop Production, Milk Yield, And Livelihood Options In Semi-Arid Regions Of Central India, Sunil Kumar, Purushottam Sharma, Prabhu Govindasamy, Maharaj Singh, Sant Kumar, Hanamant M. Halli, Bishwa Bhaskar Choudhary, Muthukumar Bagavathiannan

College of Nursing Faculty Research and Publications

Farming system research (FSR) is on-farm research that brings cutting-edge agricultural technologies to growers to enhance farm production, family income, and livelihood status. In 2007, an on-farm study was started on FSR in central India, and the effect was assessed after 5 yr (2012–2013) of implementation by comparing adopters and nonadopters of FSR-based promoted technologies. Further, in 2018–2019, the status of adoption of introduced technologies was also assessed. The study revealed that improved practices such as pre-sowing irrigation, high-yielding varieties, and crop protection measures collectively improved the system productivity of the adopters by 28%; the improved productivity was mainly due …

Helping Nurses Identify And Report Sentinel Injuries Of Child Abuse In Infants, Elizabeth Cleek, Joan P. Totka, Lynn K. Sheets, Joshua P. Mersky, Kristin Haglund

College of Nursing Faculty Research and Publications

Sentinel injuries (SIs) are some of the earliest and most readily identifiable red flags of child abuse. SIs are unexpected bruising or intra-oral injuries in pre-mobile infants and highly correlated with child abuse. However, SIs are not always recognized and reported as red flags of child abuse. Infants are left at risk for continued harm when SIs are not identified and reported. Although increasing nurses' knowledge of SIs is important, child abuse researchers and behavioral theorists have identified that knowledge alone does not predict nurses' behaviors when identifying and reporting suspected child abuse. Other predictors may include implicit biases, interpersonal …

Edge Chipping Of Translucent Zirconia, Joseph D. Flask, Geoffrey A. Thompson, Maharaj Singh, David W. Berzins

School of Dentistry Faculty Research and Publications

Statement of problem

More translucent dental zirconias have been developed by incorporating the cubic phase and reducing the tetragonal phase content that undergoes transformation toughening, leading to reduced mechanical properties. Whether the clinically relevant mechanical property of the edge chipping toughness of the material is also reduced is unclear.

Purpose

The purpose of this in vitro study was to evaluate the edge chipping toughness and translucency of translucent zirconia, 3mol% yttria-stabilized tetragonal zirconia polycrystal (3Y-TZP), and lithium disilicate.

Material and methods

Two translucent zirconia products, Katana and Lava Esthetic; one 3Y-TZP, Lava Plus; and one lithium disilicate, IPS e.max Press …

The Impact Of Nutrition Literacy And Neighborhood On Diet Quality In The Mexican Origin Population, Sylvia Pena

Dissertations (1934 -)

Introduction: Diet quality is a critical component in achieving optimal health outcomes. A poor diet can lead to various health complications including obesity, heart disease, and diabetes. Hispanic individuals have been found to have higher rates of obesity; therefore, it is critical that variables impacting diet quality be examined in this population. Available literature concerning nutrition literacy, neighborhood and diet quality have not been specific to subgroups of the Hispanic population, therefore, identifying how these factors influence the Mexican origin population is needed. The aim of this dissertation was to better understand the impact of nutrition literacy and neighborhood on …

Symmetry Is Associated With Interlimb Coordination During Walking And Pedaling After Stroke, Brice T. Cleland, Sheila M. Schindler-Ivens

Physical Therapy Faculty Research and Publications

Background and Purpose:

Asymmetry during walking may be explained by impaired interlimb coordination. We examined these associations: (1) propulsive symmetry with interlimb coordination during walking, (2) work symmetry with interlimb coordination during pedaling, and (3) work symmetry and interlimb coordination with clinical impairment.

Methods:

Nineteen individuals with chronic stroke and 15 controls performed bilateral, lower limb pedaling with a conventional device and a device with a bisected crank and upstroke assistance. Individuals with stroke walked on a split-belt treadmill. Measures of symmetry (%Propulsion_walk, %Work_ped) and interlimb phase coordination index (PCI_walk, PCI_ped) were …

Predicting Duration Of Outpatient Physical Therapy Episodes For Individuals With Spinal Cord Injury Based On Locomotor Training Strategy, Mauricio Garnier-Villarreal, Daniel Pinto, Chaithanya K. Mummidisetty, Arun Jayaraman, Candy Tefertiller, Susan Charlifue, Heather B. Tayler, Shuo-Hsiu Chang, Nicholas Mccombs, Catherine L. Furbish, Edelle C. Field-Fote, Allen W. Heinemann

Physical Therapy Faculty Research and Publications

Objective

To characterize individuals with spinal cord injuries (SCI) who use outpatient physical therapy or community wellness services for locomotor training and predict the duration of services, controlling for demographic, injury, quality of life, and service and financial characteristics. We explore how the duration of services is related to locomotor strategy.

Design

Observational study of participants at 4 SCI Model Systems centers with survival. Weibull regression model to predict the duration of services.

Setting

Rehabilitation and community wellness facilities at 4 SCI Model Systems centers.

Participants

Eligibility criteria were SCI or dysfunction resulting in motor impairment and the use of …

Influence Of Free-End Distal Extension On The Accuracy Of Guided Implant Placement: An In Vitro Study, Geoffrey Ganzman

Master's Theses (2009 -)

Purpose: The aim of this study was to evaluate the influence of type of tooth-support (bounded edentulous space versus unbounded edentulous spaces) on the accuracy of fully-guided implant placement using static computer-assisted implant surgery (sCAIS) in partially-dentate patients. Methods: Four different clinical scenarios were simulated; (a) bounded single-tooth edentulous space (BES), and three different free-end distal extensions with (b) unbounded single-tooth edentulous space (UBES1), (c) unbounded two-teeth edentulous space (UBES2), and (d) unbounded three-teeth edentulous space (UBES3). An implant planning software was used to design 3D-printed stereolithographic surgical guides for the respective clinical scenarios. In total n=140 implants with dimensions …

Edge-Chipping And Translucency Comparison Among Lithium Silicate-Based Ceramics, Essa Abdullah Alghamdi

Master's Theses (2009 -)

Purpose: The purpose of this in vitro study was to determine the edge-chipping toughness and the translucency of lithium silicate-based glass ceramics. Materials and Methods: Four lithium silicate/disilicate glass-ceramic materials, IPS e.max CAD and GC Initial LiSi blocks, and two zirconia-lithium silicate glass-ceramic materials, Vita Suprinity and Celtra Duo, were prepared and tested (n=20 specimens/group). Specimens (14 x 12 x 1.5 mm) were sectioned from commercially available chairside computer-aided design/computer-aided manufacturing (CAD-CAM) blocks, fired (if indicated), ground, and polished. Translucency was assessed via a spectrophotometer for each group. For edge chipping, specimens were adhered to a resin bed created in …

Identifying Optimal Composite Resin Depth To Maximize Fracture Resistance When Restoring Immature Endodontically Treated Teeth, David Poe

Master's Theses (2009 -)

Introduction: This study compared stress distribution of an immature central incisor restored with intracanal composite resin placed at different depths. Methods: Five pre-accessed models were prepared, to simulate immature central incisors, and endodontically treated using a mineral trioxide aggregate plug and different amounts of composite resin with gutta-percha in between the composite resin and mineral trioxide aggregate. (Group 1) Composite resin restored from the cemento-enamel junction, (group 2) composite resin restored from 2 mm apical to the cemento-enamel junction, (group 3) composite resin restored from 4 mm apical to the cemento-enamel junction, (group 4) composite resin restored from the mineral …

Associations Between The Movement Of Hard And Soft Tissues After Orthodontic Proclination Of Incisors, Scott Beard

Master's Theses (2009 -)

Objective: As orthodontic treatment planning has evolved throughout its history, there has been an increased emphasis on the facial soft tissues. Little has been done to study the effects that proclination of the incisors has on the soft tissue profile. The purpose of this study was to 1) determine if there are significant changes of lip projection and shape with proclination of incisors, and 2) determine if there are significant associations between the movement of the hard and soft tissues after proclination of the incisors. The null hypothesis is that there is no statistically different changes and associations between hard …

Exploring Relationships Between Depression Self-Stigma And Trust In Primary Care Provider On Willingness To Seek Help, Tana Karenke

Dissertations (1934 -)

Depression is a mood disorder characterized by persistent feelings of sadness and/or loss of interest that effects an individual’s ability to carry out day-to-day activities. Depression can diminish one’s social functioning, interpersonal relationships, personal care, and work productivity. Despite the availability of various treatments for depression, roughly 34% of people suffering from depression symptoms do not seek treatment. Significant barriers for seeking help for depression symptoms include the stigma of mental illness and a lack of trust in healthcare providers; however, there is a paucity of research exploring the relationship between mental illness stigma and the role of trust in …

Nonlinear Association Of Nurse Staffing And Readmissions Uncovered In Machine Learning Analysis, Olga Yakusheva, James Bang, Ronda G. Hughes, Kathleen L. Bobay, Linda L. Costa, Marianne E. Weiss

College of Nursing Faculty Research and Publications

Objective: Several studies of nurse staffing and patient outcomes found a curvilinear or U-shaped relationship, with benefits from additional nurse staffing diminishing or reversing at high staffing levels. This study examined potential diminishing returns to nurse staffing and the existence of a "tipping point" or the level of staffing after which higher nurse staffing no longer improves and may worsen readmissions.

Data Sources/Study Setting: The Readiness Evaluation And Discharge Interventions (READI) study database of over 130,000 adult (18+) inpatient discharges from 62 medical, surgical, and medical-surgical (noncritical care) units from 31 United States (US) hospitals during October 2014-March 2017.

Study …

Degenerative Cervical Myelopathy Delays Responses To Lateral Balance Perturbations Regardless Of Predictability, T. F. Boerger, L. Mcginn, M. C. Wang, Brian D. Schmit, Allison S. Hyngstrom

Physical Therapy Faculty Research and Publications

The aim of this study was to quantify balance impairments in standing in people with degenerative cervical myelopathy (PwDCM) in response to external perturbations. PwDCM have damage to their spinal cord due to degeneration of the cervical vertebral column, but little is known about balance. Balance was quantified by capturing kinetics, kinematic, and electromyographic data during standing in response to lateral waist pulls. Participants received pulls during predictable and unpredictable contexts in three stance widths at two magnitudes. In response to lateral waist pulls, PwDCM had larger center of mass excursion (P < 0.001) and delayed gluteus medius electromyography onset (P < 0.001) and peak (P < 0.001) timing. These main effects of history of myelopathy were consistent across predictability, stance width, and magnitude. A multilinear regression determined that gluteus medius peak timing + tibialis anterior peak timing most strongly predicted center of mass excursion (R2 = 0.50, P < 0.001). These data suggest that PwDCM have delays in generating voluntary and reactive motor commands, contributing to balance impairments. Future rehabilitation strategies should focus on generating rapid muscular contractions. Additionally, frontal plane postural control is regulated by the gluteus medius and the tibialis anterior, whereas other muscles (e.g. gluteus minimus, ankle invertors/evertors) not studied here may also contribute.

Prospective Telehealth Analysis Of Functional Performance, Frailty, Quality Of Life, And Mental Health After Covid-19 Hospitalization, Jacob J. Capin, Melissa P. Wilson, Kristine Hare, Swati Vempati, Carley E. Little, Donna Mcgregor, Jose Castillo-Mancilla, Jennifer E. Stevens-Lapsley, Sarah Jolley, Kristine M. Erlandson

Physical Therapy Faculty Research and Publications

Background

COVID-19 is a global pandemic with poorly understood long-term consequences. Determining the trajectory of recovery following COVID-19 hospitalization is critical for prioritizing care, allocating resources, facilitating prognosis, and informing rehabilitation. The purpose of this study was to prospectively evaluate recovery following COVID-19 hospitalization.

Methods

Participants age 18 years or older who were hospitalized for ≥24 h due to COVID-19 completed phone/video call virtual assessments (including the 10-time chair rise test) and survey forms at three time points (2–6, 12, and 18 weeks) after hospital discharge. Univariate logistic and linear regression models assessed the associations of the outcomes with primary …

Pituitary Adenylate Cyclase-Activating Polypeptide Receptor Activation In The Hypothalamus Recruits Unique Signaling Pathways Involved In Energy Homeostasis, Brian Maunze, Katherine Wood Bruckner, Nikhil Nilesh Desai, Christopher Chen, Fanghong Chen, David A. Baker, Sujean Choi

Biomedical Sciences Faculty Research and Publications

Pituitary adenylate cyclase activating polypeptide (PACAP) exerts pleiotropic effects on ventromedial nuclei (VMN) of the hypothalamus and its control of feeding and energy expenditure through the type I PAC1 receptor (PAC1R). However, the endogenous role of PAC1Rs in the VMN and the downstream signaling responsible for PACAP’s effects on energy balance are unknown. Numerous studies have revealed that PAC1Rs are coupled to both Gαs/adenylyl cyclase/protein kinase A (Gαs/AC/PKA) and Gαq/phospholipase C/protein kinase C (Gαq/PLC/PKC), while also undergoing trafficking following stimulation. To determine the endogenous role of PAC1Rs and downstream signaling that may explain PACAP’s pleiotropic effects, we used RNA interference …