Medicine and Health Sciences Commons^™

Case Reports From Women Using A Quantitative Hormone Monitor To Track The Perimenopause Transition, Maria Meyers, Richard J. Fehring, Mary Schneider

College of Nursing Faculty Research and Publications

The fertility tracking of menstrual cycles during perimenopause with a quantitative hormone monitor is a novel undertaking. Women in regular menstrual cycles have been tracking their fertility using different biomarkers since the 1960′s. Presently, there are newer electronic hormonal devices used to track fertility that provide more exact and objective data to help delineate the fertile time frame of a woman’s cycle. These devices measure quantitative levels of estrogen, the luteinizing hormone, progesterone, and follicle-stimulating hormone, all of which occur at varying levels during the menstrual cycle. As women advance toward menopause, their cycles vary in length, and their hormones …

Moderate-To-Vigorous Physical Activity Is Related With Retinal Neuronal And Axonal Integrity In Persons With Multiple Sclerosis, Jeongwoon Kim, Rachel E. Bollaert, Jonathan Cerna, Brynn C. Adamson, Connor M. Robbs, Naiman A. Khan, Robert W. Motl

Exercise Science Faculty Research and Publications

Background

Moderate-to-vigorous physical activity (MVPA) may confer benefits for axonal and/or neuronal integrity in adults with multiple sclerosis (MS).

Purpose

Examine the association between device-measured MVPA with optical coherence tomography (OCT) metrics of retinal nerve fiber layer (RNFL) thickness and total macular volume (TMV) in persons with and without MS.

Methods

Adults with MS (N = 41), along with sex-matched healthy control (HC) participants (N = 79), underwent measurements of retinal morphology via OCT and wore an accelerometer for a period of 7 days as a measure of MVPA.

Results

Persons with MS had significantly lower MVPA, RNFL thickness, and …

Bone–Patellar Tendon–Bone Autograft Harvest Prolongs Extensor Latency During Gait 2 Yr After Aclr, Naoaki Ito, Jacob J. Capin, Ashutosh Khandha, Thomas S. Buchanan, Karin Grävare Silbernagel, Lynn Snyder-Mackler

Physical Therapy Faculty Research and Publications

Purpose

Bone–patellar tendon–bone (BPTB) graft harvest for anterior cruciate ligament reconstruction alters patellar tendon properties, which inflict poor quadriceps neuromuscular function. BPTB autografts are associated with higher rates of posttraumatic osteoarthritis, which in turn is associated with pathological gait. The purpose of this study was to investigate the latency between the time of peak quadriceps activity and the peak knee flexion moment during gait, between those with BPTB grafts (n = 23) and other graft types (hamstring autograft or allografts, n = 54), 5 ± 2 months and 2 yr (25 ± 3 months) after anterior cruciate ligament reconstruction. …

Factors Influencing The Treatment Outcome Of Intentional Replantation On Teeth With Periapical Periodontitis: A Systematic Review And Meta-Analysis, Teng Kai Ong, Daniel Lim, Maharaj Singh, Alissa V. Fial

Library Faculty Research and Publications

Objectives

The purpose of this review was to appraise the quality of evidence of the existing publications on IR, and to perform a meta-analysis on the treatment outcomes of IR.

Methods

The specific PIO questions were as follows: Population: Patients with periapical periodontitis either before or after nonsurgical endodontic therapy. Intervention: IR performed with retrograde preparation and retrograde filling. Outcomes: the healing, treatment complications, and the factors influencing these outcomes after IR. Electronic and hand searches were performed in the Web of Science, PubMed, CINAHL, and Cochrane Library databases. Two authors independently screened the titles and abstracts for eligibility. The …

Effects Of Ethanol On Glun1/Glun2a And Glun1/Glun2b Nmda Receptor-Ion Channel Gating Kinetics, Robert W. Peoples, Hong Ren

Biomedical Sciences Faculty Research and Publications

Background

The N-methyl-D-aspartate receptor (NMDAR) is a major molecular target of alcohol action in the central nervous system, yet many aspects of alcohol's modulation of the activity of this ion channel remain unclear. We and others have shown that ethanol inhibition of NMDAR involves alterations in gating, especially a reduction in mean open time. However, a full description of ethanol's effects on NMDAR kinetics, including fitting them to a kinetic model, has not been reported.

Methods

To determine ethanol's effects on NMDAR kinetics, we used steady-state single-channel recording in outside-out patches from HEK-293 cells transfected with recombinant GluN1/GluN2A or …

Single Muscle Fibre Contractile Function With Ageing, Gregory J. Grosicki, Carlos S. Zepeda, Christopher W. Sundberg

Physical Therapy Faculty Research and Publications

Ageing is accompanied by decrements in the size and function of skeletal muscle that compromise independence and quality of life in older adults. Developing therapeutic strategies to ameliorate these changes is critical but requires an in-depth mechanistic understanding of the underlying physiology. Over the past 25 years, studies on the contractile mechanics of isolated human muscle fibres have been instrumental in facilitating our understanding of the cellular mechanisms contributing to age-related skeletal muscle dysfunction. The purpose of this review is to characterize the changes that occur in single muscle fibre size and contractile function with ageing and identify key areas …

Comparative Evaluation Of Artifacts Originated By Four Different Post Materials Using Different Cbct Settings, Dilek Helvacioglu-Yigit, Umut Seki, Sebnem Kursun-Cakmak, Husniye Demirturk Kocasarac, Maharaj Singh

College of Nursing Faculty Research and Publications

The aim of this study was to evaluate whether cone beam computed tomography (CBCT) images in the presence of four different post materials, obtained from different kVps with varying resolutions and varying metal artifact reduction (MAR) algorithms, differed in artifact estimation, and to compare tooth regions in terms of artifact value. Materials and Methods: Forty premolar teeth were used in this study. Root canals were treated, and teeth were randomly distributed into four subgroups (n = 10) for the preparation of post materials: titanium, gold (Nordin), quartz fiber (Bisco DT Light), and glass fiber (Rely X). The CBCT images were …

Nurses' Experiences Implementing Eped: An Ipad Application To Guide Quality Discharge Teaching, Carol Klingbeil, Cori A. Gibson, Norah L. Johnson, Michele Polfuss, Karen Gralton, Stacee M. Lerret

College of Nursing Faculty Research and Publications

Quality discharge teaching prepares patients and families to transition safely from hospital to home. Technology can enhance and support quality discharge teaching by promoting patient family engagement during the transition. The purpose of this mixed methods study was to explore clinical nurses' experience with using Engaging Parents in Education for Discharge, an iPad application to guide quality discharge teaching. Twelve nurses at a large Midwestern Children's Hospital participated in small focus groups after use of the Engaging Parents in Education for Discharge application and completed a questionnaire on their perception of the acceptability and feasibility of the app. Findings revealed …

Uncertainty And Perinatal Post-Traumatic Stress Disorder In The Neonatal Intensive Care Unit, Kathryn J. Malin, Teresa S. Johnson, Roger L. Brown, Jonathan Leuthner, Margaret Malnory, Rosemary White-Traut, Erin Rholl, Joanne Lagatta

College of Nursing Faculty Research and Publications

Parents of infants in the neonatal intensive care unit (NICU) are at increased risk of developing perinatal post-traumatic stress disorder (PPTSD), a mental health condition known to interfere with healthy parental and infant attachment. Feelings of uncertainty about illness have been theorized as an antecedent to post-traumatic stress, however the relationship has not been explored in parents of infants requiring care in the NICU. The purpose of this prospective study was to explore parental uncertainty during and after NICU discharge and the relationship between uncertainty and PPTSD. The sample consisted of 319 parents during NICU hospitalization and 245 parents at …

Single Nuclei Analyses Reveal Transcriptional Profiles And Marker Genes For Diverse Supraspinal Populations, Zachary Beine, Zimei Wang, Pantelis Tsoulfas, Murray G. Blackmore

Biomedical Sciences Faculty Research and Publications

The mammalian brain contains numerous neurons distributed across forebrain, midbrain, and hindbrain that project axons to the lower spinal cord and work in concert to control movement and achieve homeostasis. Extensive work has mapped the anatomic location of supraspinal cell types and continues to establish specific physiological functions. The patterns of gene expression that typify and distinguish these disparate populations, however, are mostly unknown. Here, using adult mice of mixed sex, we combined retrograde labeling of supraspinal cell nuclei with fluorescence-activated nuclei sorting and single-nuclei RNA sequencing analyses to transcriptionally profile neurons that project axons from the brain to lumbar …

All The Brain's A Stage For Serotonin: The Forgotten Story Of Serotonin Diffusion Across Cell Membranes, Paul W. Andrews, Catherine Bosyj, Luke Brenton, Laura Green, Paul J. Gasser, Christopher A. Lowry, Virginia M. Pickel

Biomedical Sciences Faculty Research and Publications

In the conventional model of serotonin neurotransmission, serotonin released by neurons in the midbrain raphe nuclei exerts its actions on forebrain neurons by interacting with a large family of post-synaptic receptors. The actions of serotonin are terminated by active transport of serotonin back into the releasing neuron, which is mediated by the serotonin reuptake transporter (SERT). Because SERT is expressed pre-synaptically and is widely thought to be the only serotonin transporter in the forebrain, the conventional model does not include serotonin transport into post-synaptic neurons. However, a large body of evidence accumulating since the 1970s has shown that serotonin, despite …

Joyce Roberts: Midwifery Scholar, Educator, Legend, And Friend, Mary Ellen Stanton, Lisa Hanson, Carrie Klima, Lisa Kane Low

College of Nursing Faculty Research and Publications

No abstract provided.

Monkeypox Prevention And Protecting Sex Workers: A Call To Action, Randi Beth Singer, Amy K. Johnson, Jessica L. Zemlak, Ariel Shensa, Rebecca M. Singer, Cocoa Costales, Kathleen Chiu, Jahari Stamps

College of Nursing Faculty Research and Publications

No abstract provided.

Activated Charcoal Versus A Chemical Whitening Agent: Effect On Human Enamel, Hien Thai Doan

Master's Theses (2009 -)

Objective: For many years, the conventional method to achieve a white smile has been chemical regimens such as peroxide compounds. Previous studies suggest risks associated with chemical procedures, so many are seeking out alternative options such as utilizing activated charcoal. Since this new method is rapidly trending, there have not been many scientific studies on how utilizing activated charcoal can affect the mechanical/physical properties of tooth structure. The primary objective of this study was to investigate the effect of activated charcoal on enamel’s mechanical/physical properties and compare it to a conventional tooth whitening method (carbamide peroxide). Materials and Methods: Extracted …

A Tool For Differential Diagnosis Of Childhood Apraxia Of Speech And Dysarthria In Children: A Tutorial, Jenya Iuzzini-Seigel, Kristen M. Allison, Ruth Stoeckel

Speech Pathology and Audiology Faculty Research and Publications

Purpose:

While there has been mounting research centered on the diagnosis of childhood apraxia of speech (CAS), little has focused on differentiating CAS from pediatric dysarthria. Because CAS and dysarthria share overlapping speech symptoms and some children have both motor speech disorders, differential diagnosis can be challenging. There is a need for clinical tools that facilitate assessment of both CAS and dysarthria symptoms in children. The goals of this tutorial are to (a) determine confidence levels of clinicians in differentially diagnosing dysarthria and CAS and (b) provide a systematic procedure for differentiating CAS and pediatric dysarthria in children.

Method:

Evidence …

Prologue To The Forum: Care Of The Whole Child: Key Considerations When Working With Children With Childhood Apraxia Of Speech, Jenya Iuzzini-Seigel

Speech Pathology and Audiology Faculty Research and Publications

Purpose: This prologue introduces the LSHSS Forum: Care of the Whole Child: Key Considerations When Working With Children With Childhood Apraxia of Speech. The goals of the forum are to provide (a) an overview of several co-occurring conditions and challenges that may affect children in this population and (b) methods and materials to enhance diagnostic accuracy and treatment efficacy to help children with childhood apraxia of speech (CAS) to thrive.

Method: The prologue provides an overview of what it means to care for the whole child and introduces the five articles in the forum, including research and clinical focus articles …

Defining Foundational Competence For Prelicensure And Graduate Nursing Students: A Concept Analysis And Conceptual Model, Katie L. Mcdermott, Kristina Dreifuerst

College of Nursing Faculty Research and Publications

Aim

To define the concept of foundational competence as it pertains to prelicensure and graduate nursing students during their educational program, thereby informing pedagogical and assessment practices.

Background

Competence has many definitions and uses, however a lack of consensus of a clear and useful definition in nursing persists. Without shared language, competence remains open for interpretation across and among groups and impedes the ability to teach and assess it in a competency-based education framework.

Method

Using the Walker & Avant method of concept analysis, literature was reviewed and synthesized to define and explain the concept of foundational competence in nursing …

Health Literacy And Its Association With Human Papilloma Virus Vaccination Among Adults: Findings From The Behavioral Risk Factor Surveillance System, Vinodh Bhoopathi, Bhagavatula Pradeep, Maharaj Singh

College of Nursing Faculty Research and Publications

Health literacy is associated with the utilization of preventive health services. We examined the association between health literacy (HL) levels and receipt of at least one dose of the human papilloma virus (HPV) vaccination. We analyzed the data from the 2016 Behavioral Risk Factor Surveillance System (BRFSS) among adults aged 18 to 32. The primary outcome variable was the ‘yes/no’ response to the question that assessed whether the participant received at least the first dose of HPV vaccination. The primary independent variable was a summative HL score (range 3 through 12) we created for each respondent by adding the scores …

The Association Of Preoperative Frailty And Neighborhood-Level Disadvantage With Outcome In Patients With Newly Diagnosed High Grade Glioma, Pranav Mirpuri, Maharaj Singh, Richard Rovin

College of Nursing Faculty Research and Publications

Objective

Individual patient and socioeconomic factors are underexplored prognostic factors for glioblastoma (GBM). Frailty, a measure of physiological vulnerability, and area deprivation, a measure of socioeconomic status, are easily obtained during the preoperative evaluation. These metrics are predictors of outcome and access to treatments for other cancers. Therefore, we sought to determine the association of frailty and neighborhood disadvantage with outcomes of patients with newly diagnosed GBM.

Methods

This was a retrospective review of newly diagnosed patients with GBM undergoing surgery from 2015 through 2020. The 5-factor modified frailty index and national area deprivation index were determined for each patient. …

Cerebral Venous Sinus Thrombosis Associated With Coronavirus Disease 2019: Case Report And Review Of The Literature, Kessarin Panichpisal, Ilana Ruff, Maharaj Singh, Massihullah Hamidi, Pedro D. Salinas, Kyle Swanson, Stephen Medlin, Sudeepta Dandapat, Payton Tepp, Genevieve Kuchinsky, Amy Pesch, Thomas Wolfe

College of Nursing Faculty Research and Publications

Introduction:

Coronavirus disease 2019 (COVID-19) is associated with significant risk of acute thrombosis. We present a case report of a patient with cerebral venous sinus thrombosis (CVST) associated with COVID-19 and performed a literature review of CVST associated with COVID-19 cases.

Case Report:

A 38-year-old woman was admitted with severe headache and acute altered mental status a week after confirmed diagnosis of COVID-19. Magnetic resonance imaging brain showed diffuse venous sinus thrombosis involving the superficial and deep veins, and diffuse edema of bilateral thalami, basal ganglia and hippocampi because of venous infarction. Her neurological exam improved with anticoagulation (AC) and …

Knee Joint Biomechanics During Gait Improve From 3 To 6 Months After Anterior Cruciate Ligament Reconstruction, Kelsey Neal, Jack R. Williams, Abdulmajeed Alfayyadh, Jacob J. Capin, Ashutosh Khandha, Kurt Manal, Lynn Snyder-Mackler, Thomas S. Buchanan

Physical Therapy Faculty Research and Publications

Gait alterations after anterior cruciate ligament reconstruction (ACLR) are commonly reported and have been linked to posttraumatic osteoarthritis development. While knee gait alterations have been studied at several time points after ACLR, little is known about how these biomechanical variables change earlier than 6 months after surgery, nor is much known about how they differ over the entire stance phase of gait. The purpose of this study was to examine knee gait biomechanical variables over their entire movement pattern through stance at both 3 and 6 months after ACLR and to study the progression of interlimb asymmetry between the two …

Effect Of Educational Intervention On Improving Nurse’S General Health In Military Hospitals Of Iran: A Quasi-Experimental Study, Vahid Ranaei, Fatemeh Kalroozi, Mojtaba Sadeghi, Soudabeh Yarmohammadi, Kristin Haglund, Nahid Mehrabi

College of Nursing Faculty Research and Publications

Background Nursing in military hospitals affects their general health. Educational interventions can help to maintain the general health of nurses. This study aimed to evaluate the effect of an educational intervention to improve the general health of nurses in military hospitals. Methods In this quasi-experimental study, 146 nurses working in military hospitals in Tehran, Iran in 2021 were included in the study. The one-month educational intervention included videos, pamphlets, and motivational messages about promoting general health. General health questionnaire with 28 items (GHQ28) was study tool. The allocation of nurses to groups was not random, it was based on personal …

Vasopressin Resets The Central Circadian Clock In A Manner Influenced By Sex And Vasoactive Intestinal Polypeptide Signaling, Kayla E. Rohr, Thomas Inda, Jennifer A. Evans

Biomedical Sciences Faculty Research and Publications

Background/Aims: Circadian rhythms in behavior and physiology are programmed by the suprachiasmatic nucleus (SCN) of the hypothalamus. A subset of SCN neurons produce the neuropeptide arginine vasopressin (AVP), but it remains unclear whether AVP signaling influences the SCN clock directly.

Methods: Here, we test that AVP signaling acting through V1A and V1B receptors influences molecular rhythms in SCN neurons. V1 receptor agonists were applied ex vivo to PERIOD2::LUCIFERASE SCN slices, allowing for real-time monitoring of changes in molecular clock function.

Results: V1A/B agonists reset the phase of the SCN molecular clock in a time-dependent manner, with larger magnitude responses by …

Role Of Physical Therapists In The Management Of Individuals At Risk For Or Diagnosed With Venous Thromboembolism: Evidence-Based Clinical Practice Guideline 2022, Ellen Hillegass, Kathleen M. Lukaszewicz, Michael Puthoff

Physical Therapy Faculty Research and Publications

No matter the practice setting, physical therapists work with patients who are at risk for or who have a history of venous thromboembolism (VTE). In 2016, the first clinical practice guideline (CPG) addressing the physical therapist management of VTE was published with support by the American Physical Therapy Association’s Academy of Cardiovascular and Pulmonary Physical Therapy and Academy of Acute Care, with a primary focus on lower extremity deep vein thrombosis (DVT). This CPG is an update of the 2016 CPG and contains the most current evidence available for the management of patients with lower extremity DVT and new key …

Implications Of The Dunning-Kruger Effect: Finding Balance Between Subjective And Objective Assessment In Debriefing Professional Development, Cynthia Sherraden Bradley, Kristina Dreifuerst, Anne Loomis, Brandon Kyle Johnson, Aimee A. Woda, Jamie Hansen

College of Nursing Faculty Research and Publications

Background

The ability to debrief is considered an essential clinical and simulation teaching skill because of the deep learning cultivated. Regulatory bodies identify the need for debriefing training and professional development followed by formative and summative assessment.

Method

The Debriefing for Meaningful Learning Evaluation Scale (DMLES) is a behaviorally anchored rating scale developed to assess 20 behaviors aligned with Debriefing for Meaningful Learning (DML). Participants from five baccalaureate pre–licensure nursing programs were recruited to receive DML training, then facilitate and record a debriefing for subjective and objective assessment using the DMLES.

Results

A total of 52 debriefers submitted 81 recorded …

Brain-Wide Analysis Of The Supraspinal Connectome Reveals Anatomical Correlates To Functional Recovery After Spinal Injury, Zimei Wang, Adam Romanski, Vatsal Mehra, Yunfang Wang, Matthew Brannigan, Benjamin C. Campbell, Gregory A. Petsko, Pantelis Tsoulfas, Murray G. Blackmore

Biomedical Sciences Faculty Research and Publications

The supraspinal connectome is essential for normal behavior and homeostasis and consists of numerous sensory, motor, and autonomic projections from brain to spinal cord. Study of supraspinal control and its restoration after damage has focused mostly on a handful of major populations that carry motor commands, with only limited consideration of dozens more that provide autonomic or crucial motor modulation. Here, we assemble an experimental workflow to rapidly profile the entire supraspinal mesoconnectome in adult mice and disseminate the output in a web-based resource. Optimized viral labeling, 3D imaging, and registration to a mouse digital neuroanatomical atlas assigned tens of …

Color Characterization Of Color Changing Orthodontic Adhesives, Megan Fried

Master's Theses (2009 -)

Objective:A popular product to facilitate removal of excess adhesive during bonding of orthodontic appliances is a color changing adhesive. Before polymerization, these materials are a bright color but upon curing, manufacturers claim they become translucent. After debonding, there is often resin embedded within the enamel, so the appearance of these materials after polymerization can affect the esthetics of a patient’s dentition. The purpose of this study was to analyze the color characteristics of various orthodontic color changing adhesives and determine if there is a significant difference in color changing capabilities and in translucency after polymerization between products. Methods:Grengloo and Blugloo …

The Accuracy And Sensitivity Of Abo Electronic Cast Radiographic Program Orthoshare 360 Compared To Manual Measurements, Lisa Nguyen

Master's Theses (2009 -)

Objective: The objective of this study was to assess the accuracy, validity, and reliability of measurements obtained by MotionView's Ortho Share 360 program compared to traditional manual measurements of 3D printed models using a standardized ABO measuring gauge. In detail, the study aimed to evaluate the difference in total ABO Cast Radiographic-Evaluation (CRE) score and individual differences among six ABO CRE parameters. The null hypothesis is that there are no statistically different scores between digital and manual measurements. Methods: 33 samples were measured based on standardized parameters determined by the ABO. The first measurements were obtained manually using ABO measuring …

Mechanism Of Mechanical Vibration In Enhancing Orthodontic Retention- Analysis Of Global Gene Expression, Shuwei Wang

Master's Theses (2009 -)

Introduction: Low-magnitude, high-frequency (LMHF) mechanical vibration has been proposed as a possible adjunctive retention method after orthodontic treatment. In this study, we explored the mechanism of using LMHF vibration to improve bone formation during retention phase. We aimed to provide insight of global gene expression and cellular activities of PDL cells under tension, as well as identify novel biomarkers for induced osteogenesis by using LMHF mechanical vibration as adjunct tool in retention phase. Materials and Methods: Human PDL cells (hPDLCs) were seeded in 6-well FLEXCELL culture plates. The wells were assigned to four experimental groups as control, stretching (ST), vibration …

The Effect Of Tray Design And Impression Material Consistencies On Accuracy Of Complete Arch Implant Supported Fixed Dental Prostheses Master Casts, Lujain Kurdi

Master's Theses (2009 -)

Purpose of this Study: The purpose of this study is to determine the accuracy and precision of complete arch implant supported fixed dental prosthesis impressions made with a low viscosity PVS while supporting the splinted impression copings with heavy viscosity PVS on a reference model simulating an all-on-4 prosthesis using both stock and custom trays. Material and Methods: A model was scanned to act as the reference model. The splinting device and custom tray were printed using FormLAb printer and custom resin tray material. Four group were included in the study. Stock tray with and without support and custom tray …