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Articles 271 - 300 of 3247

Full-Text Articles in Medicine and Health Sciences

Midlife Health Crisis Of Former Competitive Athletes: Dissecting Their Experiences Via Qualitative Study, Jacob J. Capin, Taylor Wolf, Jena Heck Street, Carolyn S. Smith, Shannon L. Lennon, William B. Farquhar, Sandra K. Hunter, Linda B. Piacentine Jan 2024

Midlife Health Crisis Of Former Competitive Athletes: Dissecting Their Experiences Via Qualitative Study, Jacob J. Capin, Taylor Wolf, Jena Heck Street, Carolyn S. Smith, Shannon L. Lennon, William B. Farquhar, Sandra K. Hunter, Linda B. Piacentine

Physical Therapy Faculty Research and Publications

Sports participation confers many health benefits yet greatly increases injury risk. Long-term health outcomes in former athletes and transition to life after competitive sports are understudied. Ending a sport may pose physical and psychosocial challenges. The purpose was to determine the lived experiences of former competitive athletes and how their sports participation impacted their long-term health and well-being. Former college varsity athletes participated in semistructured interviews focusing on their experiences, including past and current health, the impact of injuries, activity, exercise, diet and transition to life after competitive sport. Thematic analysis was completed using a collaborative, iterative process. Thirty-one (16 …


Age-Related Development Of Bilateral Coordination Of The Upper Limbs In Children And Adolescents, Samuel Nemanich, Sheila M. Schindler-Ivens Jan 2024

Age-Related Development Of Bilateral Coordination Of The Upper Limbs In Children And Adolescents, Samuel Nemanich, Sheila M. Schindler-Ivens

Physical Therapy Faculty Research and Publications

Bilateral coordination of the upper limbs (UL) is important for activities of daily living and physical activities. Motor coordination improves from childhood through adolescence. However, age-coordination trajectories for bilateral UL movements are not well-established, and it is unclear if bimanual coordination develops slower than unilateral coordination. In this study we examined age-related changes in UL coordination from childhood to late adolescence. Typically-developing children (N = 29, aged 7–17 years) performed unilateral and bilateral, antiphase cycling tasks with their ULs. Variations in cycling velocity and interlimb phase errors were computed as measures of coordination. Linear regression was used to examine …


The Effects Of Attentional Focus Instructions On Approach Jump Performance, Hanwen Liu, Scott Arnett, Dano Tolusso, Kaylee Woodard Jan 2024

The Effects Of Attentional Focus Instructions On Approach Jump Performance, Hanwen Liu, Scott Arnett, Dano Tolusso, Kaylee Woodard

Physical Therapy Faculty Research and Publications

Introduction

Attentional focus has been shown to significantly influence motor learning and performance, with external focus instructions enhancing performance compared to internal focus instructions. Research has also demonstrated that novice performance is improved when instructed to focus on skill execution processes rather than outcomes. However, this effect remains untested in complex jumping skills crucial to numerous sports.

Purpose

This study aimed to investigate the effect of internally and externally directed process and outcome focus instructions on approach jump height and approach speed in novice participants.

Methods

Twelve individuals aged 18 to 22 participated across three sessions: Familiarization, Test Session 1, …


Fostering Flexibility: How Medicare Advantage Potentially Accelerated Telehealth Benefits, Lisa M. Grabert, Grace Mccormack, Erin Trish, Kathryn L. Wagner Jan 2024

Fostering Flexibility: How Medicare Advantage Potentially Accelerated Telehealth Benefits, Lisa M. Grabert, Grace Mccormack, Erin Trish, Kathryn L. Wagner

Economics Faculty Research and Publications

In 2018, the US Congress enacted a policy permitting Medicare Advantage (MA) plans to cover telehealth services in a beneficiary’s home and through audio-only means as part of the basic benefit package of services, where prior to the policy change such benefits were only allowed to be covered as a supplemental benefit. MA plans were afforded 2 years of lead time for strategizing, negotiating, and capital investment prior to the start date (January 1, 2020) of the new coverage option. Our data analysis found basic benefit telehealth was offered by plans comprising 71% of enrollment in 2020 and increased to …


Research Priorities For Childhood Apraxia Of Speech: A Long View, Jenya Iuzzini-Seigel Jan 2024

Research Priorities For Childhood Apraxia Of Speech: A Long View, Jenya Iuzzini-Seigel

Speech Pathology and Audiology Faculty Research and Publications

This article introduces the Journal of Speech, Language, and Hearing Research Special Issue: Selected Papers From the 2022 Apraxia Kids Research Symposium. The field of childhood apraxia of speech (CAS) has developed significantly in the past 15 years, with key improvements in understanding of basic biology including genetics, neuroscience, and computational modelling; development of diagnostic tools and methods; diversity of evidence-based interventions with increasingly rigorous experimental designs; and understanding of impacts beyond impairment-level measures. Papers in this special issue not only review and synthesize the some of the substantial progress to date but also present novel findings addressing critical research …


Centering Prep: Utilizing Adapt-Itt To Inform Group Prep Care For Sex Workers In Chicago, Randi Beth Singer, Janelli Barrow, Amy K. Johnson, Jessica L. Zemlak, Natasha Crooks, Sarah Abboud, Douglas Bruce, Noel Green, Jahari Stamps, Jennifer Neely, Susan G. Sherman, Crystal L. Patil, Alicia K. Matthews Jan 2024

Centering Prep: Utilizing Adapt-Itt To Inform Group Prep Care For Sex Workers In Chicago, Randi Beth Singer, Janelli Barrow, Amy K. Johnson, Jessica L. Zemlak, Natasha Crooks, Sarah Abboud, Douglas Bruce, Noel Green, Jahari Stamps, Jennifer Neely, Susan G. Sherman, Crystal L. Patil, Alicia K. Matthews

College of Nursing Faculty Research and Publications

Background

Sex workers, those who trade sex for monetary or nonmonetary items, experience high rates of HIV transmission but have not been adequately included in HIV prevention and Pre-Exposure Prophylaxis (PrEP) adherence program development research. Community-empowered (C.E.) approaches have been the most successful at reducing HIV transmission among sex workers. Centering Healthcare (Centering) is a C.E. model proven to improve health outcomes and reduce health disparities in other populations, such as pregnant women, people with diabetes, and sickle cell disease. However, no research exists to determine if Centering can be adapted to meet the unique HIV prevention needs of sex …


Vaginal And Rectal Microbiome Changes Following Administration Of A Multi-Species Antenatal Probiotic: A Randomized Control Trial, Emily Malloy, Ashley Kates, Jonah Dixon, Colleen Riley, Nasia Safdar, Lisa Hanson Jan 2024

Vaginal And Rectal Microbiome Changes Following Administration Of A Multi-Species Antenatal Probiotic: A Randomized Control Trial, Emily Malloy, Ashley Kates, Jonah Dixon, Colleen Riley, Nasia Safdar, Lisa Hanson

College of Nursing Faculty Research and Publications

The gut and vaginal microbiome undergo changes during pregnancy which may be protective or harmful to the birthing person. Probiotics have been found to cause protective changes to the gut and vaginal microbiomes, with the potential to improve perinatal outcomes. This randomized control trial compares the vaginal and rectal microbiomes before and after an antenatal probiotic or placebo intervention, with a diverse group of pregnant people and a special focus on racial disparities. The vaginal and rectal microbiomes reveal non-significant increased Lactobacillus in the probiotics group, with a greater increase in participants who identified as Black. Potential implications and future …


Why We Quit: Relationships Between Work-Related Burnout, Work Rewards, And Intention To Leave In Nursing, Jacqueline Christianson, Abir K. Bekhet, Jill L. Guttormson, Maharaj Singh, Norah L. Johnson Jan 2024

Why We Quit: Relationships Between Work-Related Burnout, Work Rewards, And Intention To Leave In Nursing, Jacqueline Christianson, Abir K. Bekhet, Jill L. Guttormson, Maharaj Singh, Norah L. Johnson

College of Nursing Faculty Research and Publications

Burnout and pay satisfaction were associated with intention to leave the profession; however, overall compensation dollar amount was not correlated with intention to leave. Approaches to nurse retention should employ a multifaceted approach to effectively enhance retention rates.


Feasibility And Acceptability Of Studying Full-Time Nurse Faculty Salaries, Kathryn J. Malin, Jessica L. Zemlak, Jacqueline Christianson, Jessica Leiberg, Lisa M. Grabert Jan 2024

Feasibility And Acceptability Of Studying Full-Time Nurse Faculty Salaries, Kathryn J. Malin, Jessica L. Zemlak, Jacqueline Christianson, Jessica Leiberg, Lisa M. Grabert

College of Nursing Faculty Research and Publications

Background

The nursing shortage is driven, in part, by the critical shortage of nursing faculty. Consequently, qualified potential nursing students are being turned away from nursing schools each year. The preeminent issue influencing the United States nurse faculty workforce shortage is salary; financial compensation is higher in clinical and private-sector settings than educational settings. The purpose of this study is to describe current full-time nurse faculty salary, sources of income, and perceived need for more income, as well as the feasibility and acceptability of research focused on full-time nurse faculty salaries, so to guide future nursing faculty workforce research.

Methods …


Positive Thinking Training Intervention For Nursing Students To Foster Resilience: Assessing Critical Parameters From Students’ Perspectives, Abir K. Bekhet, Karen Nakhla, Denise M. Matel-Anderson, Alexandra Rominger, Hernan Cano, Joshua Scherf, Alexis Dart, Daniel Nakhla Jan 2024

Positive Thinking Training Intervention For Nursing Students To Foster Resilience: Assessing Critical Parameters From Students’ Perspectives, Abir K. Bekhet, Karen Nakhla, Denise M. Matel-Anderson, Alexandra Rominger, Hernan Cano, Joshua Scherf, Alexis Dart, Daniel Nakhla

College of Nursing Faculty Research and Publications

The COVID-19 pandemic impacted not only the physical but also the mental health of the American population. Anxiety and depression have increased three-fold since the pandemic [1]. The Centers for Disease Control and Prevention (CDC) 2021 survey revealed that approximately 33% of the American population have anxiety symptoms and 28% have depressive symptoms as compared to 11% and 4% of anxiety and depression respectively in 2019 [1]. Also, Research showed that the rate of suicidal ideations during the pandemic is higher than that reported prior to pandemic, suggesting that this may result in higher suicide rates in future [2]. Nursing …


Grounded Theory Approach To Understand Self-Management Of Opioid Recovery Through Pregnancy And Early Parenting, Nicole M. Mattson, Jennifer M. Ohlendorf, Kristin Haglund Jan 2024

Grounded Theory Approach To Understand Self-Management Of Opioid Recovery Through Pregnancy And Early Parenting, Nicole M. Mattson, Jennifer M. Ohlendorf, Kristin Haglund

College of Nursing Faculty Research and Publications

Objective

To develop a theory to explain the processes women use to self-manage recovery from opioid use disorder during pregnancy, the postpartum period, and early parenting.

Design

Constructivist grounded theory approach.

Participants

Women (N = 16) who gave birth during the past 12 months and used medication for opioid use disorder for recovery through pregnancy and the postpartum period.

Methods

We recruited participants through seven medication-assisted treatment clinics in a mid-size Midwestern city and the surrounding suburbs and through online parenting and recovery community groups with national-based memberships. We conducted semistructured, individual audio interviews from November 2020 to July …


Does Money Matter? Exploring Pay Disparities For Nursing Faculty Educators, Jacqueline Christianson, Jessica L. Zemlak, Kathryn J. Malin, Lisa M. Grabert Jan 2024

Does Money Matter? Exploring Pay Disparities For Nursing Faculty Educators, Jacqueline Christianson, Jessica L. Zemlak, Kathryn J. Malin, Lisa M. Grabert

College of Nursing Faculty Research and Publications

Key Takeaways:

  • The nurse faculty shortage must be addressed to meet the healthcare needs of the public.
  • The salary gap between academic nurse educators and clinical practice nurses likely contributes to the nurse faculty shortage.
  • Additional investments are necessary to recruit and retain sufficient nursing faculty.


Exploring Racial Disparities In Sex Trafficking Special Docket Court Programs, Aaron Murnan, Gwen England, Samantha J. Boch, Caneacha Matthews, Henry Ofori Duah, Islam Qasem, Sarah Manchak Jan 2024

Exploring Racial Disparities In Sex Trafficking Special Docket Court Programs, Aaron Murnan, Gwen England, Samantha J. Boch, Caneacha Matthews, Henry Ofori Duah, Islam Qasem, Sarah Manchak

College of Nursing Faculty Research and Publications

Purpose: The United States criminal legal system has a long-standing and well-documented history of perpetuating racial disparities in health and well-being through inequitable policing, sentencing, and incarceration practices. In the last decade, the criminal legal system has re-considered their response to women arrested for solicitation via sex trafficking specialty courts. Methods: The current study leverages publicly available data from one large Midwestern county to explore the presence of racial disparities within women’s referral to, election to participate in, and success within one specialty court program for women in the sex trade. Results: Between 1990 and 2022, approximately 27,790 women were …


Generational Differences In Moral Injury, Resilience, And Well-Being Among Nurses: Predictors Of Intention To Leave Position And Profession, Minjin Kim, Jin Jun, Joshua Lambert, Henry Ofori Duah, Sharon J. Tucker, Dónal P. O’Mathúna, Grant Pignatiello, Joyce J. Fitzpatrick Jan 2024

Generational Differences In Moral Injury, Resilience, And Well-Being Among Nurses: Predictors Of Intention To Leave Position And Profession, Minjin Kim, Jin Jun, Joshua Lambert, Henry Ofori Duah, Sharon J. Tucker, Dónal P. O’Mathúna, Grant Pignatiello, Joyce J. Fitzpatrick

College of Nursing Faculty Research and Publications

Background:

The COVID-19 pandemic highlighted the negative impact of moral injury on nurses’ well-being. However, there is a lack of research about generational differences among nurses, particularly on newer nurses who have been identified as having a higher rate of intention to leave.

Objective:

This study examines generational differences among nurses on moral injury, well-being, resilience, and intention to leave their nursing position and profession.

Methods:

This is a secondary analysis of cross-sectional data from registered nurses in clinical practice in Ohio between July and August 2021. Data on demographics, moral injury, resilience, and well-being were collected using an online …


Childhood Obesity Interventions Need To Address Groups Experiencing Inequities, Marilyn Frenn Jan 2024

Childhood Obesity Interventions Need To Address Groups Experiencing Inequities, Marilyn Frenn

College of Nursing Faculty Research and Publications

No abstract provided.


Emphasizing Self-Regulation In Teaching: Reducing Disruption To Students’ Learning During Unplanned Instructional Mode Transition, Somesh Roy, Amber Young-Brice, Jenna Lassila, Brandon Kyle Johnson Jan 2024

Emphasizing Self-Regulation In Teaching: Reducing Disruption To Students’ Learning During Unplanned Instructional Mode Transition, Somesh Roy, Amber Young-Brice, Jenna Lassila, Brandon Kyle Johnson

College of Nursing Faculty Research and Publications

In Spring 2020, engineering faculty transitioned to emergency remote instruction due to COVID-19. This mixed-methods study was done to understand the correlation between self-regulated learning and how students experienced the emergency transition to remote learning. The participants were from an upper-level engineering course, with 33 students surveyed four times during the semester. Seven students were interviewed after the semester. Findings revealed that during the transition to remote learning, students perceived less change if they had higher degrees of self-regulation. The qualitative analysis also revealed that transparency in learning and teaching also played an important role in students’ perceptions.


Process Of Maintaining Self In Individuals Living With Systemic Sclerosis: A Grounded Theory Study Of American Women, Donald D. Miller, Jennifer J. Doering Jan 2024

Process Of Maintaining Self In Individuals Living With Systemic Sclerosis: A Grounded Theory Study Of American Women, Donald D. Miller, Jennifer J. Doering

College of Nursing Faculty Research and Publications

Background: People with chronic illnesses may struggle to adapt psychologically to the illness experience and have feelings of identity loss, self-diminishment, and biographical disruption. This may limit people’s ability to engage in optimal selfmanagement. Systemic sclerosis is a debilitating, stigmatizing, and life-limiting progressive chronic illness with significant disfiguring effects. Little is known about the identity management process in people with disfiguring and debilitating conditions such as systemic sclerosis.

Purpose: The purpose of this study was to generate a grounded theory explicating the process of maintaining a sense of self in people living with systemic sclerosis.

Methods: Fifteen women with systemic …


Activity Levels Across The Intensity Spectrum In Athletes: A Systematic Review Protocol, Jacob J. Capin, Jena Heck Street, Alissa V. Fial, Nicola D. Ridgers, Grant R. Tomkinson Jan 2024

Activity Levels Across The Intensity Spectrum In Athletes: A Systematic Review Protocol, Jacob J. Capin, Jena Heck Street, Alissa V. Fial, Nicola D. Ridgers, Grant R. Tomkinson

Physical Therapy Faculty Research and Publications

Physical activity (PA) promotes better cardiometabolic health, physical function, brain health and longevity. In contrast, prolonged sedentary behaviour (SB) is a risk factor for many chronic diseases and poor health. Limited research has evaluated or synthesised how competitive sports participation influences PA across the lifespan. Some evidence suggests, ironically, that former competitive athletes may be insufficiently active and current athletes may be highly sedentary away from sport. This study describes the protocol for a systematic review and meta-analysis on activity levels across the intensity spectrum in athletes, addressing the primary research question: is sports participation significantly associated with PA and/or …


Immunohistochemical Analysis Of Dentigerous Cysts And Odontogenic Keratocysts Associated With Impacted Third Molars—A Systematic Review, Luis Eduardo Almeida, David Lloyd, Daniel Boettcher, Olivia Kraft, Samuel Zammuto Jan 2024

Immunohistochemical Analysis Of Dentigerous Cysts And Odontogenic Keratocysts Associated With Impacted Third Molars—A Systematic Review, Luis Eduardo Almeida, David Lloyd, Daniel Boettcher, Olivia Kraft, Samuel Zammuto

School of Dentistry Faculty Research and Publications

Objective: This systematic review investigates the diagnostic, prognostic, and therapeutic implications of immunohistochemical markers in dentigerous cysts (DCs) and odontogenic keratocysts (OKCs) associated with impacted third molars.

Materials and Methods: A comprehensive search strategy was employed across major databases including MEDLINE/PubMed, EMBASE, and Web of Science, from the inception of the databases to March 2024. Keywords and Medical Subject Heading (MeSH) terms such as “dentigerous cysts”, “odontogenic keratocysts”, “immunohistochemistry”, “Ki-67”, and “p53” were used. The PRISMA 2020 guidelines were followed to ensure methodological rigor. Inclusion criteria encompassed studies on humans and animals providing definitive diagnoses or specific signs and symptoms …


Comparison Of Dmft And Behavior Rating Scores Between Children With Systemic Disease And Healthy Children At The First Dental Visit, Gizem Erbaş Ünverdi, Beste Ozgur, H. Cem Güngör, Paul S. Casamassimo Jan 2024

Comparison Of Dmft And Behavior Rating Scores Between Children With Systemic Disease And Healthy Children At The First Dental Visit, Gizem Erbaş Ünverdi, Beste Ozgur, H. Cem Güngör, Paul S. Casamassimo

School of Dentistry Faculty Research and Publications

Purpose: To evaluate and compare oral health and behavior scores at the first dental visit and dental treatment need using general anesthesia/sedation (GA/S) of children with systemic diseases (SD) and healthy children.

Methods: Data were obtained from healthy children (n = 87) and children with SD (n = 79), aged 4 to 6 years, presenting to a hospital dental clinic for a first dental examination. The total number of decayed, missing and filled teeth (dmft), dental behavior score using Frankl Scale, and dental treatment need using GA/S were recorded. Chi-square / Fisher’s exact test and Mann–Whitney U …


Exploring And Describing Current Behavioral And Social Sciences Curricula In Predoctoral Dental Programs, Casey D. Wright, Lance Brendan Young Jan 2024

Exploring And Describing Current Behavioral And Social Sciences Curricula In Predoctoral Dental Programs, Casey D. Wright, Lance Brendan Young

School of Dentistry Faculty Research and Publications

Purpose

To maintain accreditation status, predoctoral dental programs in the United States and Canada are required to train future dentists in the fundamentals of behavioral sciences. Each program independently determines how to fulfill this task, and little information exists on the consistency of training across programs. The purpose of this study was to identify the range of topics currently taught in predoctoral dental programs in the United States and Canada, who teaches them, and the modes of instruction and assessment.

Methods

Invitations to complete an online survey were emailed to faculty responsible for, or familiar with, the behavioral sciences curricula …


Heart Rate Variability Is Reduced In Covid-19 Survivors And Associated With Physical Activity And Fatigue, Michael H. Haischer, Lauren E. Opielinski, Lindsey M. Mirkes, Toni D. Uhrich, Rachel E. Bollaert, Michael E. Danduran, Marie K. Hoeger Bement, Linda B. Piacentine, Paula E. Papanek, Sandra K. Hunter Jan 2024

Heart Rate Variability Is Reduced In Covid-19 Survivors And Associated With Physical Activity And Fatigue, Michael H. Haischer, Lauren E. Opielinski, Lindsey M. Mirkes, Toni D. Uhrich, Rachel E. Bollaert, Michael E. Danduran, Marie K. Hoeger Bement, Linda B. Piacentine, Paula E. Papanek, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Reduced heart rate variability (HRV) and fatigue are common after COVID-19 infection and both are potentially influenced by physical activity (PA). We compared resting HRV, PA from accelerometers and questionnaires, and self-reported fatigue in 41 COVID-19 survivors (~8 months postinfection, 38 ± 17 years) with 41 matched controls. Differences in HRV were observed on acceleration capacity (p = 0.041), deceleration capacity (p = 0.032), high-frequency peak frequency (p = 0.019), absolute low-frequency power (p = 0.042), relative very low-frequency power (p = 0.012), SD2 (from Poincare plot; p = 0.047), and DFA2 (slope of long-term …


Middle-Range Scores From The Patient Determined Disease Steps Scale Reflect Varying Levels Of Walking Dysfunction In Multiple Sclerosis, Robert W. Motl, Whitney Neal, Deborah Backus, Jeffrey Hebert, Kevin K. Mccully, Francois Bethoux, Prudence Plummer, Alexander V. Ng, John Lowman, Hollie Schmidt, Robert Mcburney, Gary R. Cutter Jan 2024

Middle-Range Scores From The Patient Determined Disease Steps Scale Reflect Varying Levels Of Walking Dysfunction In Multiple Sclerosis, Robert W. Motl, Whitney Neal, Deborah Backus, Jeffrey Hebert, Kevin K. Mccully, Francois Bethoux, Prudence Plummer, Alexander V. Ng, John Lowman, Hollie Schmidt, Robert Mcburney, Gary R. Cutter

Exercise Science Faculty Research and Publications

Background

Multiple sclerosis (MS) is a leading cause of neurological disability among young and middle-aged adults worldwide, and disability is measured using a variety of approaches, including patient reported outcome measures (PROMs) such as the Patient Determined Disease Steps (PDDS) scale. There is limited evidence for the validity of inferences from the middle-range of scores on the PDDS (i.e., 3 “gait disability” – 6 “bilateral support”), but that range of scores seemingly represents moderate disability characterized by varying levels of walking dysfunction.

Purpose

The current study examined whether the middle-range of scores from the PDDS reflect varying levels of walking …


Evaluating Surgical Approaches For Hemimandibular Hyperplasia Associated With Osteochondroma: A Systematic Literature Review, Luis Eduardo Almeida, Samuel Zammuto, Diego Fernando Lopez Jan 2024

Evaluating Surgical Approaches For Hemimandibular Hyperplasia Associated With Osteochondroma: A Systematic Literature Review, Luis Eduardo Almeida, Samuel Zammuto, Diego Fernando Lopez

School of Dentistry Faculty Research and Publications

Background/Objectives: Hemimandibular hyperplasia (HH) associated with osteochondroma presents complex challenges in maxillofacial surgery, including facial asymmetry, occlusal instability, and temporomandibular joint (TMJ) dysfunction. Surgical interventions vary widely in approach and outcomes, underscoring the need for a systematic evaluation of effectiveness. This systematic review assesses the effectiveness of surgical approaches for managing HH associated with osteochondroma, focusing on techniques including condylectomy, orthognathic surgery, distraction osteogenesis, total joint replacement (TJR), and genioplasty. Methods: Following PRISMA 2020 guidelines, a comprehensive search was conducted in PubMed, Scopus, and Web of Science for studies published from 2000 to 2023. Eligibility criteria were based on the …


Bayesian Rare Variant Analysis Identifies Novel Schizophrenia Putative Risk Genes, Shengtong Han Jan 2024

Bayesian Rare Variant Analysis Identifies Novel Schizophrenia Putative Risk Genes, Shengtong Han

School of Dentistry Faculty Research and Publications

The genetics of schizophrenia is so complex that it involves both common variants and rare variants. Rare variant association studies of schizophrenia are challenging because statistical methods for rare variant analysis are under-powered due to the rarity of rare variants. The recent Schizophrenia Exome meta-analysis (SCHEMA) consortium, the largest consortium in this field to date, has successfully identified 10 schizophrenia risk genes from ultra-rare variants by burden test, while more risk genes remain to be discovered by more powerful rare variant association test methods. In this study, we use a recently developed Bayesian rare variant association method that is powerful …


Association Between Periodontal Health Status And Quality Of Life: A Cross-Sectional Study, Kinan M. Al-Bitar, Jeffery M. Garcia, Shengtong Han, Arndt Guentsch Jan 2024

Association Between Periodontal Health Status And Quality Of Life: A Cross-Sectional Study, Kinan M. Al-Bitar, Jeffery M. Garcia, Shengtong Han, Arndt Guentsch

School of Dentistry Faculty Research and Publications

Introduction: Attachment loss due to periodontal diseases is associated with functional limitations as well as physical pain and psychological discomfort, which may lead to a reduced quality of life. The purpose of this study is to determine if the oral health status, specifically the periodontal status, influences oral health–related quality of life.

Materials and methods: Survey data were collected in a US dental school clinical setting in a cross-sectional study. Quality of life related to oral health was assessed with the Oral Health Impact Profile-49 (OHIP-49). In addition, DMFT index, periodontal status, and health literacy scores (dental and medical health …


Expression Of The Vesicular Gaba Transporter Within Neuromedin S+ Neurons Sustains Behavioral Circadian Rhythms, Ivana L. Bussi, Alexandra F. Neitz, Raymond E. A. Sanchez, Leandro P. Casiraghi, Michael Moldavan, Divya Kunda, Charles N. Allen, Jennifer A. Evans, Horacio O. De La Iglesia Dec 2023

Expression Of The Vesicular Gaba Transporter Within Neuromedin S+ Neurons Sustains Behavioral Circadian Rhythms, Ivana L. Bussi, Alexandra F. Neitz, Raymond E. A. Sanchez, Leandro P. Casiraghi, Michael Moldavan, Divya Kunda, Charles N. Allen, Jennifer A. Evans, Horacio O. De La Iglesia

Biomedical Sciences Faculty Research and Publications

The suprachiasmatic nucleus (SCN) of the hypothalamus is the site of a central circadian clock that orchestrates overt rhythms of physiology and behavior. Circadian timekeeping requires intercellular communication among SCN neurons, and multiple signaling pathways contribute to SCN network coupling. Gamma-aminobutyric acid (GABA) is produced by virtually all SCN neurons, and previous work demonstrates that this transmitter regulates coupling in the adult SCN but is not essential for the nucleus to sustain overt circadian rhythms. Here, we show that the deletion of the gene that codes for the GABA vesicular transporter Vgat from neuromedin-S (NMS)+ neurons—a subset of neurons …


Designing And Validating Novel Communication Measures For Pediatric, Adolescent, And Young Adult Oncology Care And Research: The Pedcom Measures, Bryan A. Sisk, Amy R. Newman, Dandan Chen, Jennifer W. Mack, Bryce B. Reeve Dec 2023

Designing And Validating Novel Communication Measures For Pediatric, Adolescent, And Young Adult Oncology Care And Research: The Pedcom Measures, Bryan A. Sisk, Amy R. Newman, Dandan Chen, Jennifer W. Mack, Bryce B. Reeve

College of Nursing Faculty Research and Publications

Background

High-quality communication in pediatric and adolescent cancer is the standard of care. Yet, we lack pediatric-specific communication measures. We designed self-report and caregiver-report communication measures for use in pediatric oncology settings.

Methods

We recruited adolescent and young adults (AYAs; 12–24 years) with cancer and parents of children and AYAs between 1 month post-diagnosis and 2 months after completing treatment. Participants completed measures including 58 questions addressing eight previously characterized communication functions. For each function, we conducted factor analysis, and assessed reliability and construct validity. Based on psychometric properties, we created final long-form (31 items) and short-form (eight items) communication …


Community Or Commodity? Perceived Nurse Support During The Covid-19 Pandemic, Jacqueline Christianson, Madaline Mccarthy, Bonnie Sommers-Olson, Jill L. Guttormson, Norah L. Johnson Dec 2023

Community Or Commodity? Perceived Nurse Support During The Covid-19 Pandemic, Jacqueline Christianson, Madaline Mccarthy, Bonnie Sommers-Olson, Jill L. Guttormson, Norah L. Johnson

College of Nursing Faculty Research and Publications

This cross-sectional study aimed to understand how nurses perceived community and healthcare institution support during the COVID-19 pandemic. Five themes are described: healthcare institution resource provision, presence and camaraderie, perceived commodification versus supportive gestures, nurses as heroes, and erosion of support over time.


Feasibility Of Stress Research In Premature Infant–Maternal Dyads During And After Neonatal Intensive Care Unit Hospitalization, Kathryn J. Malin, Kristin Kruschel, Kaboni W. Gondwe, Joanne Lagatta, C. Sue Carter, Hossein P. Nazarloo, Yvette P. Conley, Rosemary White-Traut Dec 2023

Feasibility Of Stress Research In Premature Infant–Maternal Dyads During And After Neonatal Intensive Care Unit Hospitalization, Kathryn J. Malin, Kristin Kruschel, Kaboni W. Gondwe, Joanne Lagatta, C. Sue Carter, Hossein P. Nazarloo, Yvette P. Conley, Rosemary White-Traut

College of Nursing Faculty Research and Publications

Background:

Stress from preterm infant admission to the neonatal intensive care unit (NICU) is associated with infant and maternal physiologic changes, including endocrine and epigenetic alterations. Little is known about the mechanisms connecting NICU stress to biologic changes, and whether preterm infant and maternal stress are reciprocal. As a preliminary step, feasibility and acceptability of measuring indicators of stress are required.

Purpose:

This study evaluated the feasibility and acceptability of research examining perceptions and biologic markers of stress in premature infant–maternal dyads during and after NICU hospitalization.

Methods:

We evaluated study feasibility using a longitudinal descriptive design. Acceptability was measured …