Medicine and Health Sciences Commons^™

Only Women Report Increase In Pain Threshold Following Fatiguing Contractions Of The Upper Extremity, Kathy J. Lemley, Jonathon Senefeld, Sandra K. Hunter, Marie K. Hoeger Bement

Physical Therapy Faculty Research and Publications

Purpose

The perception of pain in response to a noxious stimulus can be markedly reduced following an acute bout of exercise [exercise-induced hypoalgesia (EIH)]. Sex differences in EIH frequently occur after exercise but may be confounded by the sex differences in muscle fatigue. The purpose was to determine if sex differences in pain relief occur after an exercise protocol when muscle fatigue is similar for both young and older men and women.

Methods

Pain perception of 33 men (15 young) and 31 women (19 young) was measured using a pressure pain stimulus on the left index finger before and after …

Mechanical Properties Of Copper-Nickel-Titanium Archwires, Margaret Amelia Rosen

Master's Theses (2009 -)

Introduction: The initial phase of orthodontic therapy relies on flexible wires, usually composed of a nickel-titanium alloy, to apply a substantially constant load during tooth movement. Copper has been added to nickel-titanium archwires, resulting in an alloy with potential clinical advantages such as a lower stress hysteresis. Many orthodontic companies claim that their copper-nickel-titanium manufacturing process allows for the production of more consistent transition temperatures in the wires, allowing the orthodontist to customize treatment to various patients based on the force level needed. There are currently many manufacturers of these wires, creating a wide range of copper-nickel-titanium archwires from which …

Snpredict: A Machine Learning Approach For Detecting Low Frequency Variants In Cancer, Vatsal Mehra

Master's Theses (2009 -)

Cancer is a genetic disease caused by the accumulation of DNA variants such as single nucleotide changes or insertions/deletions in DNA. DNA variants can cause silencing of tumor suppressor genes or increase the activity of oncogenes. In order to come up with successful therapies for cancer patients, these DNA variants need to be identified accurately. DNA variants can be identified by comparing DNA sequence of tumor tissue to a non-tumor tissue by using Next Generation Sequencing (NGS) technology. But the problem of detecting variants in cancer is hard because many of these variant occurs only in a small subpopulation of …

Rna-Seq Analysis Of Localized Mst1/Stk4 Expression In Prostate Cancer, Damien Ready

Master's Theses (2009 -)

The SKT4-encoded MST1 is a serine-threonine protein kinase and has known associations with many diseases and cancer.MST1 plays a critical component of the Hippo tumor suppressor pathway responsible for limiting cell division and promoting apoptosis.Loss of MST1 function is associated with poor prognostic outcomes for cancers, though the mechanism is not well understood.There is increasing evidence that dysregulation of MST1 can lead to castration-resistant prostate cancer (CRPCa), an aggressive cancer with limited treatment options.To better understand the mechanistic underpinnings of CRPCa progression, C4-2 prostate cancer cells were engineered toexpress MST1 protein directed to a particular subcellular region: membrane, nucleus, or …

The Effect Of Orthodontic Appliances On The Evaluation Of The Professionalism And Esthetics Of An Adult Employee, Laura Hanson Vaccariello

Master's Theses (2009 -)

This study explored the influence of fixed and removable orthodontic appliances on participants’ ratings of the job performance, intelligence, and attractiveness of an adult female. Ninety-four adult subjects were recruited from the Graduate School of Management at Marquette University. Each subject received an identical employee performance review with an attached photograph of a female employee. The smile of the photo was manipulated to represent one of four conditions: no orthodontic appliance, a metal orthodontic appliance, a ceramic orthodontic appliance, or a clear aligner. Subjects then rated the employee on three continuous Likert scales. Ratings of job performance, intelligence, and attractiveness …

The Effects Of Mechanical Vibration On Human Chondrocytes In Vitro, Bradley J. Gauthier

Master's Theses (2009 -)

Introduction: Inflammation is the biological basis of temporomandibular joint disorders (TMD), when severe it can lead to osteoarthritis. One of the physical therapies used to manage this condition is mechanical vibration, as has been used in medicine for many years as a non-pharmacological therapy. Recently an FDA approved dental device called AcceleDent has been introduced to increase the rate of tooth movement and decrease pain. As the device-generated vibration transmits to the TMJ, it is important for us to investigate whether mechanical vibration influences TMJ on its biologic basis – chondrocytes under normal and inflammatory conditions. Materials and Methods: Human …

The Effect Of Mechanical Vibration On Human Pdl Cell Differentiation And Response To Inflammation, Megan Desroches

Master's Theses (2009 -)

Low magnitude mechanical vibration is a therapeutic adjunct being investigated to alter bone remodeling and inflammation in areas such as osteoporosis, bone fracture healing, and muscle soreness after exercise. In orthodontics a device named AcceleDent has been marketed that claims to increase the rate of tooth movement and decrease pain. However evidence for these claims is lacking. In this study we looked at two potential cellular mechanisms for these claims: periodontal ligament (PDL) cell differentiation and inflammation under an orthodontic model of strain (IL-1β). Increased PDL cell differentiation into osteogenic cells could be an avenue of increasing orthodontic tooth movement. …

Collective Timekeeping Among Cells Of The Master Circadian Clock, Jennifer A. Evans

Biomedical Sciences Faculty Research and Publications

The suprachiasmatic nucleus (SCN) of the anterior hypothalamus is the master circadian clock that coordinates daily rhythms in behavior and physiology in mammals. Like other hypothalamic nuclei, the SCN displays an impressive array of distinct cell types characterized by differences in neurotransmitter and neuropeptide expression. Individual SCN neurons and glia are able to display self-sustained circadian rhythms in cellular function that are regulated at the molecular level by a 24h transcriptional–translational feedback loop. Remarkably, SCN cells are able to harmonize with one another to sustain coherent rhythms at the tissue level. Mechanisms of cellular communication in the SCN network are …

Shared Care Contributions To Self-Care And Quality Of Life In Chronic Cardiac Patients, Margaret Sebern, Roger Brown, Patricia Flatley Brennan

College of Nursing Faculty Research and Publications

Shared care is an interpersonal interaction system composed of communication, decision making, and reciprocity; it is used by patients and family caregivers (care dyads) to exchange social support. This study’s purpose was to describe the contributions of shared care to outcomes for individuals with cardiac disease. A secondary data analysis was used to answer the following questions. What is the association between elements of shared care and patient outcomes? Do dyad perceptions of shared care differentially contribute to patient outcomes? Participants in this study were 93 individuals with a cardiac disease and 93 family caregivers. Composite index structured equation modeling …

Parents’ Perspectives On Shared Decision Making For Children With Solid Organ Transplants, Stacee M. Lerret, Kristin Haglund, Norah L. Johnson

College of Nursing Faculty Research and Publications

Introduction

The Institute of Medicine prioritizes active family and clinician participation in treatment decisions, known as shared decision making (SDM). In this article we report the decision-making experiences for parents of children who had a solid organ transplant.

Method

We performed a prospective longitudinal mixed methods study at five major U.S. children's medical centers. Qualitative interview data were obtained at 3 weeks, 3 months, and 6 months after hospital discharge following the child's transplant.

Results

Forty-eight parents participated in the study. Three themes were identified: (a) Parents expect to participate in SDM; (b) parents seek information to support their participation …

Transition Of Experienced And New Graduate Nurses To A Pediatric Hospital, Carol Klingbeil, Rachel F. Schiffman, Carolyn Ziebert, Joan P. Totka, Catherine A. Schmitt, Lynn Doyle, Ashley Stelter, Alice V. Stonek, Weiming Ke, Norah L. Johnson

College of Nursing Faculty Research and Publications

This study reports on the 3-, 6-, 12-, and 18-month outcomes of 118 newly hired registered nurses (RNs) who completed a 12-month transition-to-practice program at a pediatric hospital. Experienced RNs (n = 42) and new graduate RNs (n = 76) showed improved organization, prioritization, communication, and leadership skills over time. The experienced RNs reported better communication and leadership skills than the new graduate nurses. Results inform transition program development for both new and experienced nurses.

The American Association of Colleges of Nursing (2012) predicts that, without a multifaceted approach, a national nursing shortage will occur by 2020. Many nurses leave …

Engaging Nursing Staff In Research: The Clinical Nurse Specialist Role In An Academic-Clinical Partnership, Lynn Gettrust, Mary E. Hagle, Lesley Boaz, Margaret J. Bull

College of Nursing Faculty Research and Publications

Purpose: The purpose of this article is to describe the processes of exploring and implementing an academic-clinical study, engaging nursing staff in research, and maintaining their enthusiasm within the context of an academic-clinical research partnership.

Description: The core competencies of the clinical nurse specialist (CNS) role address evidence-based practice, quality improvement, and research. Studies and exemplars of the CNS role in the literature illustrate expert practitioner and facilitator of evidence-based practice, but less attention is given to methods used by the CNS to engage staff in clinical research.

Outcome: The CNS was successful in obtaining staff engagement in the research …

Nurses' Own Birth Experiences Influence Labor Support Attitudes And Behaviors, Ann P. Aschenbrenner, Lisa Hanson, Teresa S. Johnson, Sheryl Talcott Kelber

College of Nursing Faculty Research and Publications

Objective

To describe the attitudes of intrapartum nurses about the importance of and intent to provide professional labor support (PLS); barriers to PLS, such as perceived subjective norms and perceived behavioral control; and relationships among attitudes, behaviors, and nurse and site characteristics.

Design

A cross-sectional, mixed-methods, descriptive design was guided by the Theory of Planned Behavior.

Setting

Three hospital sites in one region of a single Midwestern state.

Participants

Sixty intrapartum nurses participated.

Methods

The Labor Support Questionnaire and demographic questionnaire were administered online. The Labor Support Questionnaire is used to measure attitudes about the importance of and intended behaviors …

Pilot Testing The Debriefing For Meaningful Learning Evaluation Scale, Cynthia Sherraden Bradley, Kristina Dreifuerst

College of Nursing Faculty Research and Publications

Background

Debriefing for Meaningful Learning (DML), an evidence-based debriefing method, promotes thinking like a nurse through reflective learning. Despite widespread adoption of DML, little is known about how well it is implemented. To assess the effectiveness of DML implementation, an evaluative rubric was developed and tested.

Sample

Three debriefers who had been trained to use DML at least 1 year previously, submitted five recorded debriefings each for evaluation.

Methods

Three raters who were experts in DML scored each of the 15 recorded debriefing session using DML Evaluation Scale (DMLES). Observable behaviors were scored with binary options. These raters also assessed …

Submaximal Oxygen Uptake Kinetics, Functional Mobility, And Physical Activity In Older Adults With Heart Failure And Reduced Ejection Fraction, Scott L. Hummel, John Herald, Craig Alpert, Kimberlee A. Gretebeck, Wendy S. Champoux, Donald R. Dengel, Peter V. Vaitkevicius, Neil B. Alexander

College of Nursing Faculty Research and Publications

Background: Submaximal oxygen uptake measures are more feasible and may better predict clinical cardiac outcomes than maximal tests in older adults with heart failure (HF). We examined relationships between maximal oxygen uptake, submaximal oxygen kinetics, functional mobility, and physical activity in older adults with HF and reduced ejection fraction.

Methods: Older adults with HF and reduced ejection fraction (n = 25, age 75 ± 7 years) were compared to 25 healthy age- and gender-matched controls. Assessments included a maximal treadmill test for peak oxygen uptake (VO2peak), oxygen uptake kinetics at onset of and on recovery from a submaximal treadmill test, …

Effect Of Sequence Of Simulated And Clinical Practicum Learning Experiences On Clinical Competency, Jamie Hansen

Dissertations (1934 -)

Delivery of clinical education using the traditional model involving faculty supervision of students in a hospital setting has become increasingly difficult for schools of nursing due to factors such as increased student enrollment and decreased clinical site availability. Simulated learning experiences (SLE) have increasingly been used as a supplement or replacement for a portion of nursing students’ traditional clinical learning experiences (CLE). There has been a call for research to ensure that new models for delivery of clinical education are built on a foundation of research. Although SLE have been increasingly used as a supplement to CLE, it is unknown …

Evaluation Of An Oral Health Education Session For Early Head Start Home Visitors, Kevin Glatt, Christopher Okunseri, Diane Flanagan, Pippa Simpson, Yumei Cao, Earnestine Willis

School of Dentistry Faculty Research and Publications

Objectives

Home visiting programs promote the education and health of Early Head Start (EHS) children and pregnant women. However, EHS's oral health component is unevenly implemented. We conducted an educational intervention to improve oral health knowledge and motivational interviewing techniques among Wisconsin EHS home visitors.

Methods

A questionnaire assessing oral health-related knowledge and confidence was administered to home visitors before and after an educational session. Changes between pre/post-responses were analyzed with McNemar's test and Wilcoxon Signed Rank test.

Results

After the intervention there were increases in both knowledge and confidence related to oral health communication. Knowledge increases were observed in …

Wearing Complete Dental Prostheses - Effects On Perioral Morphology, Gregor F. Raschke, Philipp Eberl, Geoffrey A. Thompson, Arndt Guentsch, Andre Peisker, Stefan Schultze-Mosgau, Marta Gomez-Dammeier, Gabriel Djedovic, Ulrich M. Rieger, Florian Beuer

School of Dentistry Faculty Research and Publications

Background: To adequately perform rehabilitation of edentulous patients by a complete removable dental prosthesis (CRDP) is from basic interest to dentists to understand the morphologic changes caused by re-establishment of a physiologic jaw relationship. Anthropometric analyses of standardized frontal view and profile photographs may help elucidate such changes. Material and Methods: Photographs of 31 edentulous patients were compared in relaxed lip closure and after insertion of a CRDP in stable occlusion. 2232 anthropometric distances were raised. Eighteen anthropometric indices reflecting the perioral morphology and its integration in the vertical facial harmony were investigated. Results: The intercanthal – mouth width index …

Longterm Quality Of Life After Oncologic Surgery And Microvascular Free Flap Reconstruction In Patients With Oral Squamous Cell Carcinoma, Andre Peisker, Gregor F. Raschke, Arndt Guentsch, Korosh Roshanghias, Francy Eichmann, Stefan Schultze-Mosgau

School of Dentistry Faculty Research and Publications

Background: Quality of life (QoL) has become increasingly important in cancer treatment. It refers to the patient’s perception of the effects of the disease and therapy, and their impact on daily functioning and general feeling of well being. Material and Methods: In this prospective study, a total of 100 patients treated at our institution, completed the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire and the specific EORTC QLQ-H&N35 module. The questionnaires were distributed to the patients between 12 and 60 months postoperatively. Results: Global QoL score was 58.3 and mean score for functioning scale was 76.7. …

Comparison Of The Transformation Temperatures Of Heat-Activated Nickel-Titanium Orthodontic Archwires By Two Different Techniques, Noor Aminah Obaisi, Maria Therese S. Galang-Boquieren, Carla A. Evans, Tzong Guang Peter Tsay, Grace Viana, David W. Berzins, Spiro Megremis

School of Dentistry Faculty Research and Publications

Objectives

The purpose of this study was to investigate the suitability of the Bend and Free Recovery (BFR) method as a standard test method to determine the transformation temperatures of heat-activated Ni-Ti orthodontic archwires. This was done by determining the transformation temperatures of two brands of heat-activated Ni-Ti orthodontic archwires using the both the BFR method and the standard method of Differential Scanning Calorimetry (DSC). The values obtained from the two methods were compared with each other and to the manufacturer-listed values.

Methods

Forty heat-activated Ni-Ti archwires from both Rocky Mountain Orthodontics (RMO) and Opal Orthodontics (Opal) were tested using …

Spirituality And Religiosity In Adolescents Living With Sickle Cell Disease, Dora L. Clayton-Jones, Kristin Haglund, Ruth Ann Belknap, Jame Schaefer, Alexis A. Thompson

College of Nursing Faculty Research and Publications

This study purports to address paucity in the literature regarding how adolescents with sickle cell disease (SCD) describe and experience spirituality and religiosity (S/R). This was a qualitative descriptive study. Two semi-structured interviews were conducted with nine adolescents (M_age = 16.2 years). Data were analyzed using a template analysis style and a concurrent analysis process of data reduction. Three major themes encompassed the participants’ descriptions of the relationships between S/R, health and illness in their lives including S/R as sources for coping, influence of S/R beliefs on health and illness, and sharing S/R with Health Care Providers (HCPs). …

Effects Of Laryngeal Restriction On Pharyngeal Peristalsis And Biomechanics: Clinical Implications, Rita Shaker, Patrick Sanvanson, Gokulakrishnan Balasubramanian, Mark Kern, Ashley Wuerl, Allison S. Hyngstrom

Physical Therapy Faculty Research and Publications

To date, rehabilitative exercises aimed at strengthening the pharyngeal muscles have not been developed due to the inability to successfully overload and fatigue these muscles during their contraction, a necessary requirement for strength training. The purpose of this study was to test the hypothesis that applying resistance against anterosuperior movement of the hyolaryngeal complex will overload the pharyngeal muscles and by repetitive swallowing will result in their fatigue manifested by a reduction in pharyngeal peristaltic amplitude. Studies were done in two groups. In group 1 studies 15 healthy subjects (age: 42 ± 14 yr, 11 females) were studied to determine …

Intersubunit Interactions At Putative Sites Of Ethanol Action In The M3 And M4 Domains Of The Nmda Receptor Glun1 And Glun2b Subunits, Robert W. Peoples, Hong Ren, Yulin Zhao

Biomedical Sciences Faculty Research and Publications

Background and Purpose: The N-methyl-D-aspartate (NMDA) receptor is an important target of alcohol action in the brain. Recent studies in this laboratory have demonstrated that alcohol-sensitive positions in the intersubunit interfaces of the M3 and M4 domains of GluN1 and GluN2A subunits interact with respect to ethanol sensitivity and receptor kinetics, and that alcohol-sensitive positions in the M domains of GluN2A and GluN2B subunits differ. In this study we tested for interactions among alcohol-sensitive positions at the M domain intersubunit interfaces in GluN1/GluN2B NMDA receptors.

Experimental Approach: We used whole-cell patch-clamp recording in tsA201 cells expressing tryptophan substitution mutants at …

Educating Family Caregivers For Older Adults About Delirium: A Systematic Review, Margaret J. Bull, Lesley Boaz, Martha G. Jermé

College of Nursing Faculty Research and Publications

Background

Delirium in older adults is considered a medical emergency; it contributes to a cascade of functional decline and to increased mortality. Early recognition of delirium symptoms is critical to prevent these negative consequences. Family caregivers who are educated about delirium could partner with nurses and other healthcare professionals in early recognition of delirium symptoms. Before implementing such partnership models, it is important to examine the effectiveness of educating family caregivers about delirium.

Aims

To examine whether providing education on delirium to family caregivers improved their knowledge, emotional state, or response in reducing the incidence of delirium in older adults. …

Mentors And Role Models: Two Approaches For Inspiration, Gary L. Stafford

School of Dentistry Faculty Research and Publications

No abstract provided.

Microfluidic Manipulation Of Core/Shell Nanoparticles For Oral Delivery Of Chemotherapeutics: A New Treatment Approach For Colorectal Cancer, Mohammad Mahdi Hasani-Sadrabadi, Shahrouz Taranejoo, Erfan Dashtimoghadam, Ghasem Bahlakeh, Fatemeh Sadat Majedi, Jules John Vandesarl, Mohsen Janmaleki, Fatemeh Sharifi, Arnaud Bertsch, Kerry Hourigan, Lobat Tayebi, Phillippe Renaud, Karl I. Jacob

School of Dentistry Faculty Research and Publications

A microfluidics approach to synthesize core–shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.

Three-Dimensional Bioprinting Materials With Potential Application In Preprosthetic Surgery, Mina D. Fahmy, Hossein E. Jazayeri, Mehdi Razavi, Radi Masri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Current methods in handling maxillofacial defects are not robust and are highly dependent on the surgeon’s skills and the inherent potential in the patients’ bodies for regenerating lost tissues. Employing custom-designed 3D printed scaffolds that securely and effectively reconstruct the defects by using tissue engineering and regenerative medicine techniques can revolutionize preprosthetic surgeries. Various polymers, ceramics, natural and synthetic bioplastics, proteins, biomolecules, living cells, and growth factors as well as their hybrid structures can be used in 3D printing of scaffolds, which are still under development by scientists. These scaffolds not only are beneficial due to their patient-specific design, but …

Removable Partial Dentures Vs Overdentures In Children With Ectodermal Dysplasia: Two Case Reports, Georgios Maroulakos, Ioli I. Artopoulou, Matina V. Angelopoulou, Dimitris Emmanouil

School of Dentistry Faculty Research and Publications

Ectodermal dysplasia (ED) represents a disorder group characterised by abnormal development of the ectodermal derivatives. Removable partial dentures (RPD), complete dentures (CD) or overdentures (OD) are most often the treatment of choice for young affected patients. Prosthetic intervention is of utmost importance in the management of ED patients, as it resolves problems associated with functional, aesthetic, and psychological issues, and improves a patient’s quality of life. However, few studies present the principles and guidelines that can assist in the decision-making process of the most appropriate removable prosthesis. The purpose of this study was to suggest a simple treatment decision-making algorithm …

Reliability And Validity Of Ratings Of Perceived Exertion In Persons With Multiple Sclerosis, Brice T. Cleland, Benjamin A. Ingraham, Molly C. Pitluck, Alexander V. Ng

Exercise Science Faculty Research and Publications

Objective: To test the reliability and validity of using the Borg rating of perceived exertion (RPE) scale (ratings 6e20) in persons with multiple sclerosis (PwMS).

Design: Nonrandomized repeated measures.

Setting: Research laboratory.

Participants: Volunteer sample (N=27) comprised of 16 PwMS (10 women) and 11 age-matched persons without multiple sclerosis (MS) (6 women). Clinical measures included symptomatic fatigue, depression, and MS functional capacity.

Interventions: A submaximal cycling test was performed to estimate maximal capacity. Participants then pedaled for 2 minutes at 50% and 60% of predicted maximal oxygen consumption per unit time (V̇O₂), and physiological measures and RPE were …

Optogenetic Interrogation Of Functional Synapse Formation By Corticospinal Tract Axons In The Injured Spinal Cord, Naveen Jayaprakash, Zimei Wang, Brian Hoeynck, Nicholas Krueger, Audra A. Kramer, Eric Balle, Daniel S. Wheeler, Robert A. Wheeler, Murray G. Blackmore

Biomedical Sciences Faculty Research and Publications

To restore function after injury to the CNS, axons must be stimulated to extend into denervated territory and, critically, must form functional synapses with appropriate targets. We showed previously that forced overexpression of the transcription factor Sox11 increases axon growth by corticospinal tract (CST) neurons after spinal injury. However, behavioral outcomes were not improved, raising the question of whether the newly sprouted axons are able to form functional synapses. Here we developed an optogenetic strategy, paired with single-unit extracellular recordings, to assess the ability of Sox11-stimulated CST axons to functionally integrate in the circuitry of the cervical spinal cord. Initial …