Medicine and Health Sciences Commons^™

We Have The Program, What Now? Development Of An Implementation Plan To Bridge The Research-Practice Gap Prevalent In Exercise Oncology, Mary A. Kennedy, Sara Bayes, Robert U. Newton, Yvonne Zissiadis, Nigel A. Spry, Dennis R. Taaffe, Nicolas H. Hart, Michael Davis, Aileen Eiszele, Daniel A. Galvão

Research outputs 2014 to 2021

© 2020 The Author(s). Background: Exercise has emerged as a promising therapy for people with cancer. Novel programs have been developed to translate research into practice; however, implementation barriers have limited their success in part because successful translation of exercise oncology research into practice requires context-specific implementation plans. The aim of this study was to employ the implementation mapping protocol to develop an implementation plan to support programming of a co-located exercise clinic and cancer treatment center. Methods: The Implementation Mapping protocol, which consists of five specific iterative tasks, was used. A stakeholder advisory group advised throughout the process. Results: …

A Bitter Pill To Swallow: Registered Nurses And Medicines Regulation In Remote Australia, Katie R. Pennington, Kim D. Clark, Sabina Knight

Research outputs 2014 to 2021

INTRODUCTION: Access to essential medicines is a human right and an objective of the National Medicines Policy in Australia. Health workforce distribution characteristics in remote Australia implies registered nurses (RNs) may find themselves responsible for a broader range of activities in the medication management cycle than they would be elsewhere in the nation. The regulation of health professionals and their training requirements provides essential but complex protections for the public. These protections include the National Registration and Accreditation Scheme for health practitioners and the Australian Health Practitioner Regulation Agency. Other levels of control or regulation are also exerted over health …

Copper Toxicity Links To Pathogenesis Of Alzheimer’S Disease And Therapeutics Approaches, Hafza Wajeeha Ejaz, Wei Wang, Minglin Lang

Research outputs 2014 to 2021

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Alzheimer’s disease (AD) is an irreversible, age-related progressive neurological disorder, and the most common type of dementia in aged people. Neuropathological lesions of AD are neurofibrillary tangles (NFTs), and senile plaques comprise the accumulated amyloid-beta (Aβ), loaded with metal ions including Cu, Fe, or Zn. Some reports have identified metal dyshomeostasis as a neurotoxic factor of AD, among which Cu ions seem to be a central cationic metal in the formation of plaque and soluble oligomers, and have an essential role in the AD pathology. Cu-Aβ complex catalyzes the generation of …

Psychological Symptoms In Chinese Nurses May Be Associated With Predisposition To Chronic Disease: A Cross-Sectional Study Of Suboptimal Health Status, Jinxiu Zhu, Wenjuan Ying, Li Zhang, Gangyi Peng, Weiju Chen, Enoch Odame Anto, Xueqing Wang, Nan Lu, Shanshan Gao, Guihai Wu, Jingyi Yan, Jianfeng Ye, Shenglin Wu, Chengzhi Yu, Minghui Yue, Xiru Huang, Nuo Xu, Pengxiang Ying, Yanhong Chen, Xuerui Tan, Wei Wang

Research outputs 2014 to 2021

© 2020, The Author(s). Background: Suboptimal health status (SHS) is a reversible state between ideal health and illness and it can be effectively reversed by risk prediction, disease prevention, and personalized medicine under the global background of predictive, preventive, and personalized medicine (PPPM) concepts. More and more Chinese nurses have been troubled by psychological symptoms (PS). The correlation between PS and SHS is unclear in nurses. The purpose of current study is to investigate the prevalence of SHS and PS in Chinese nurses and the relationship between SHS and PS along with predisposing factors as well as to discuss the …

The Global, Regional, And National Burden Of Oesophageal Cancer And Its Attributable Risk Factors In 195 Countries And Territories, 1990-2017: A Systematic Analysis For The Global Burden Of Disease Study 2017, Farin Kamangar, Dariush Nasrollahzadeh, Saeid Safiri, Sadaf G. Sepanlou, Christina Fitzmaurice, Kevin S. Ikuta, Catherine Bisignano, Farhad Islami, Gholamreza Roshandel, Stephen S. Lim, Hassan Abolhassani, Eman Abu-Gharbieh, Rufus Adesoji Adedoyin, Shailesh M. Advani, Muktar Beshir Ahmed, Miloud Taki Eddine Aichour, Tomi Akinyemiju, Chisom Joyqueenet Akunna, Fares Alahdab, Vahid Alipour, Amir Almasi-Hashiani, Abdulaziz M. Almulhim, Nahla Hamed Anber, Alireza Ansari-Moghaddam, Jalal Arabloo, Morteza Arab-Zozani, Atalel Fentahun Awedew, Alaa Badawi, Kathleen S. Sachiko Berfield, Kidanemaryam Berhe, Krittika Bhattacharyya, Antonio Biondi, Tone Bjørge, Antonio M. Borzì, Cristina Bosetti, Giulia Carreras, Felix Carvalho, Clara Castro, Dinh-Toi Chu, Vera Marisa Costa, Baye Dagnew, Jiregna Darega Gela, Ahmad Daryani, Feleke Mekonnen Demeke, Gebre Teklemariam Demoz, Mostafa Dianatinasab, Iffat Elbarazi, Mohammad Hassan Emamian, Arash Etemadi, Pawan Sirwan Faris, Eduarda Fernandes, Irina Filip, Florian Fischer, Mohamed M. Gad, Silvano Gallus, Abadi Kahsu Gebre, Tsegaye Tewelde Gebrehiwot, Gebreamlak Gebremedhn Gebremeskel, Begashaw Melaku Gebresillassie, Fatemah Ghasemi-Kebria, Ahmad Ghashghaee, Nermin Ghith, Mahaveer Golechha, Giuseppe Gorini, Rahul Gupta, Nima Hafezi-Nejad, Arvin Haj-Mirzaian, James D. Harvey, Maryam Hashemian, Hamid Yimam Hassen, Simon I. Hay, Andualem Henok, Chi Linh Hoang, H. Dean Hosgood, Mowafa Househ, Olayinka Stephen Ilesanmi, Milena D. Ilic, Seyed Sina Naghibi Irvani, Charvi Jain, Spencer L. James, Sun Ha Jee, Ravi Prakash Jha, Farahnaz Joukar, Ali Kabir, Amir Kasaeian, Mesfin Wudu Kassaw, Supreet Kaur, Andre Pascal Kengne, Esma Kerboua, Yousef Saleh Khader, Rovshan Khalilov, Ejaz Ahmad Khan, Abdullah T. Khoja, Jonathan M. Kocarnik, Hamidreza Komaki, Vivek Kumar, Carlo La Vecchia, Savita Lasrado, Bingyu Li, Alan D. Lopez, Azeem Majeed, Navid Manafi, Ana Laura Manda, Fariborz Mansour-Ghanaei, Manu Raj Mathur, Varshil Mehta, Dhruv Mehta, Walter Mendoza, Prasanna Mithra, Karzan Abdulmuhsin Mohammad, Abdollah Mohammadian-Hafshejani, Reza Mohammadpourhodki, Jemal Abdu Mohammed, Farnam Mohebi, Ali H. Mokdad, Lorenzo Monasta, Delaram Moosavi, Mahmood Moosazadeh, Ghobad Moradi, Farhad Moradpour, Rahmatollah Moradzadeh, Gurudatta Naik, Lonut Negoi, Haruna Asura Nggada, Huong Lan Thi Nguyen, Rajan Nikbakhsh, Molly R. Nixon, Andrew T. Olagunju, Jagadish Roa. Padubidri, Keyvan Pakshir, Shanti Patel, Mona Pathak, Hai Quang Pham, Akram Pourshams, Navid Rabiee, Mohammad Rabiee, Amir Radfar, Alireza Rafiei, Kiana Ramezanzadeh, Goura Kishor Rath, Priya Rathi, Salman Rawaf, David Laith Rawaf, Nima Rezaei, Elias Merdassa Roro, Anas M. Saad, Hamideh Salimzadeh, Abdallah M. Samy, Benn Sartorius, Arash Sarvaezad, Mario Sekerija, Feng Sha, Morteza Shamsizadeh, Sara Sheikhbahaei, Reza Shirkoohi, Sudeep K. Siddappa Malleshappa, Jasvinder A. Singh, Dhirendra Narain Sinha, Catalin-Gabriel Smarandache, Sergey Soshnikov, Hafiz Ansar Rasul Suleria, Degena Bahrey Tadesse, Berhe Etsay Tesfay, Bhaskar Thakur, Eugenio Traini, Khanh Bao Tran, Bach Xuan Tran, Irfan Ullah, Marco Vacante, Yousef Veisani, Isidora S. Vujcic, Girmay Teklay Weldesamuel, Rixing Xu, Vahid Yazdi-Feyzabadi, Deniz Yuce, Vesna Zadnik, Zoubida Zaidi, Zhi-Jiang Zhang, Reza Malekzadeh, Mohsen Naghavi, Gbd 2017 Oesophageal Cancer Collaborators

Research outputs 2014 to 2021

© 2020 The Author(s). Background Oesophageal cancer is a common and often fatal cancer that has two main histological subtypes: oesophageal squamous cell carcinoma and oesophageal adenocarcinoma. Updated statistics on the incidence and mortality of oesophageal cancer, and on the disability-adjusted life-years (DALYs) caused by the disease, can assist policy makers in allocating resources for prevention, treatment, and care of oesophageal cancer. We report the latest estimates of these statistics for 195 countries and territories between 1990 and 2017, by age, sex, and Socio-demographic Index (SDI), using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 …

Circulating Tumour Dna In Advanced Melanoma Patients Ceasing Pd1 Inhibition In The Absence Of Disease Progression, Lydia Warburton, Leslie Calapre, Michelle Pereira, Anna Reid, Cleo Robinson, Benhur Amanuel, Mel Ziman, Michael Millward, Elin Gray

Research outputs 2014 to 2021

Immunotherapy is an important and established treatment option for patients with advanced melanoma. Initial anti-PD1 trials arbitrarily defined a two-year treatment duration, but a shorter treatment duration may be appropriate. In this study, we retrospectively assessed 70 patients who stopped anti-PD1 therapy in the absence of progressive disease (PD) to determine clinical outcomes. In our cohort, the median time on treatment was 11.8 months. Complete response was attained at time of anti-PD1 discontinuation in 61 (87%). After a median follow up of 34.2 months (range: 2–70.8) post discontinuation, 81% remained disease free. Using ddPCR, we determine the utility of circulating …

Validation And Reliability Of The Alzheimer’S Disease-Commonwealth Scientific And Industrial Research Organisation Food Frequency Questionnaire, Samantha L. Gardener, Philippa Lyons-Wall, Ralph Martins, Stephanie Rainey-Smith

Research outputs 2014 to 2021

Accuracy in measuring intake of dietary constituents is an important issue in studies reporting the associations between diet and chronic diseases. We modified a Commonwealth Scientific and Industrial Research Organisation (CSIRO) food frequency questionnaire (FFQ) to include foods of interest in the field of Alzheimer’s disease (AD) research. The aim of the current study was to determine the reliability and validity of the AD-CSIROFFQ in 148 cognitively normal older adults. The AD-CSIROFFQ was completed before and after completion of a four-day weighed food record. Of the 508 food and beverage items reported, 309 had sufficient consumption levels for analysis of …

Co-Occurrence Across Time And Space Of Drug- And Cannabinoid- Exposure And Adverse Mental Health Outcomes In The National Survey Of Drug Use And Health: Combined Geotemporospatial And Causal Inference Analysis, Albert Stuart Reece, Gary Hulse

Research outputs 2014 to 2021

Background: Whilst many studies have linked increased drug and cannabis exposure to adverse mental health (MH) outcomes their effects on whole populations and geotemporospatial relationships are not well understood.

Methods

Ecological cohort study of National Survey of Drug Use and Health (NSDUH) geographically-linked substate-shapefiles 2010–2012 and 2014–2016 supplemented by five-year US American Community Survey. Drugs: cigarettes, alcohol abuse, last-month cannabis use and last-year cocaine use. MH: any mental illness, major depressive illness, serious mental illness and suicidal thinking. Data analysis: two-stage, geotemporospatial, robust generalized linear regression and causal inference methods in R.

Results

410,138 NSDUH respondents. Average response rate 76.7%. …

Are Heat Shock Proteins An Important Link Between Type 2 Diabetes And Alzheimer Disease?, Joanne Elizabeth Rowles, Kevin Noel Keane, Thiago Gomes Heck, Vinicius Cruzat, Giuseppe Verdile, Philip Newsholme

Research outputs 2014 to 2021

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Type 2 diabetes (T2D) and Alzheimer’s disease (AD) are growing in prevalence worldwide. The development of T2D increases the risk of AD disease, while AD patients can show glucose imbalance due to an increased insulin resistance. T2D and AD share similar pathological features and underlying mechanisms, including the deposition of amyloidogenic peptides in pancreatic islets (i.e., islet amyloid polypeptide; IAPP) and brain (β-Amyloid; Aβ). Both IAPP and Aβ can undergo misfolding and aggregation and accumulate in the extracellular space of their respective tissues of origin. As a main response to protein …

Biceps Brachii Muscle Hardness Assessed By A Push-In Meter In Comparison To Ultrasound Strain Elastography, Mitsuyoshi Murayama, Kazunori Nosaka, Takayuki Inami, Norihiro Shima, Tsugutake Yoneda

Research outputs 2014 to 2021

© 2020, The Author(s). This study investigated the relationship between push-in meter (PM) and ultrasound strain elastography (USE) for biceps brachii (BB) muscle hardness. BB hardness of 21 young men was assessed by PM and USE during rest and isometric contractions of six different intensities (15, 30, 45, 60, 75, 90% of maximal voluntary contraction: MVC) at 30°, 60° and 90° elbow flexion. Muscle hardness (E) was calculated from the force–displacement relationship in PM, and strain ratio (SR) between an acoustic coupler (elastic modulus: 22.6 kPa) and different regions of interest (ROIs) in BB was calculated and converted to Young’s …

A Platform In The Use Of Medicines To Treat Chronic Hepatitis C (Platinum C): Protocol For A Prospective Treatment Registry Of Real-World Outcomes For Hepatitis C, Jessica Ramsay, Julie Marsh, Alisa Pedrana, Nada Andric, Richard Norman, Wendy Cheng, Steve Webb, Nikolajs Zeps, Matthew Bellgard, Todd Graves, Margaret Hellard, Tom Snelling

Research outputs 2014 to 2021

© 2020, The Author(s). Background: Safe, highly curative, short course, direct acting antiviral (DAA) therapies are now available to treat chronic hepatitis C. DAA therapy is freely available to all adults chronically infected with the hepatitis C virus (HCV) in Australia. If left untreated, hepatitis C may lead to progressive hepatic fibrosis, cirrhosis and hepatocellular carcinoma. Australia is committed to eliminating hepatitis as a public health threat by 2030 set by the World Health Organization. However, since the introduction of funded DAA treatment, uptake has been suboptimal. Australia needs improved strategies for testing, treatment uptake and treatment completion to address …

Automated Smart Home Assessment To Support Pain Management: Multiple Methods Analysis, Roschelle L. Fritz, Marian Wilson, Gordana Dermody, Maureen Schmitter-Edgecombe, Diane J. Cook

Research outputs 2014 to 2021

©Roschelle L Fritz, Marian Wilson, Gordana Dermody, Maureen Schmitter-Edgecombe, Diane J Cook. Objective: This study aimed to determine if a smart home can detect pain-related behaviors to perform automated assessment and support intervention for persons with chronic pain.Background: Poorly managed pain can lead to substance use disorders, depression, suicide, worsening health, and increased use of health services. Most pain assessments occur in clinical settings away from patients’ natural environments. Advances in smart home technology may allow observation of pain in the home setting. Smart homes recognizing human behaviors may be useful for quantifying functional pain interference, thereby creating new ways …

Concordant Peripheral Lipidome Signatures In Two Large Clinical Studies Of Alzheimer’S Disease, Kevin Huynh, Wei Ling Florence Lim, Corey Giles, Kaushala S. Jayawardana, Agus Salim, Natalie A. Mellett, Adam Alexander T. Smith, Gavriel Olshansky, Brian G. Drew, Pratishtha Chatterjee, Ian Martins, Simon M. Laws, Ashley I. Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Matthias Arnold, Kwangsik Nho, Andrew J. Saykin, Rebecca Baillie, Xianlin Han, Rima Kaddurah-Daouk, Ralph N. Martins, Peter J. Meikle

Research outputs 2014 to 2021

© 2020, The Author(s). Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer’s disease (AD). Lipids are complex molecules comprising many isomeric and isobaric species, necessitating detailed analysis to enable interpretation of biological significance. Our expanded targeted lipidomics platform (569 species across 32 classes) allows for detailed lipid separation and characterisation. In this study we examined peripheral samples of two cohorts (AIBL, n = 1112 and ADNI, n = 800). We are able to identify concordant peripheral signatures associated with prevalent AD arising from lipid pathways including; ether lipids, sphingolipids (notably GM3 gangliosides) and lipid …

Tumour Pd-L1 Expression In Small-Cell Lung Cancer: A Systematic Review And Meta-Analysis, Emmanuel Acheampong, Afaf Abed, Michael Morici, Samantha Bowyer, Benhur Amanuel, Weitao Lin, Michael Millward, Elin S. Gray

Research outputs 2014 to 2021

: Antibodies against programmed death-1 (PD-1), and its ligand, (PD-L1) have been approved recently for the treatment of small-cell lung cancer (SCLC). Although there are previous reports that addressed PD-L1 detection on tumour cells in SCLC, there is no comprehensive meta-analysis on the prevalence of PD-L1 expression in SCLC. We performed a systematic search of the PubMed, Cochrane Library and EMBASE databases to assess reports on the prevalence of PD-L1 expression and the association between PD-L1 expression and overall survival (OS). This meta-analysis included 27 studies enrolling a total of 2792 patients. The pooled estimate of PD-L1 expression was 26.0% …

Comparing Web-Based Mindfulness With Loving-Kindness And Compassion Training For Promoting Well-Being In Pregnancy: Protocol For A Three-Arm Pilot Randomized Controlled Trial, Amy Louise Finlay-Jones, Jacqueline Ann Davis, Amanda O'Donovan, Keerthi Kottampally, Rebecca Anne Ashley, Desiree Silva, Jeneva Lee Ohan, Susan L. Prescott, Jenny Downs

Research outputs 2014 to 2021

© Amy Louise Finlay-Jones, Jacqueline Ann Davis, Amanda O'Donovan, Keerthi Kottampally, Rebecca Anne Ashley, Desiree Silva, Jeneva Lee Ohan, Susan L Prescott, Jenny Downs. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 14.10.2020. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on http://www.researchprotocols.org, as well as this copyright and license information must be included. Background: Promoting psychological well-being and preventing …

Single Nucleotide Polymorphisms In Lcat May Contribute To Dyslipidaemia In Hiv-Infected Individuals On Haart In A Ghanaian Population, Simon Bannison Bani, Kwabena Owusu Danquah, Christian Obirikorang, William K. B. A. Owiredu, Lawrence Quaye, Edmund Muonir Der, Emmanuel Acheampong, Yussif Adams, Peter Paul M. Dapare, Moses Banyeh, Enoch Odame Anto, Samuel Asamoah Sakyi

Research outputs 2014 to 2021

© 2020, The Author(s). Highly active antiretroviral therapy (HAART) is known to cause lipid abnormalities such as dyslipidaemia in HIV-infected individuals. Yet, dyslipidaemia may not independently occur as it may be worsened by single nucleotide polymorphisms (SNPs) in lecithin cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL). This case–control study was conducted in three-selected hospitals in the Northern part of Ghana. The study constituted a total of 118 HIV-infected participants aged 19–71 years, who had been on HAART for 6–24 months. Dyslipidaemia was defined based on the NCEP-ATP III criteria. HIV-infected individuals on HAART with dyslipidaemia were classified as cases while …

“Cultural Security Is An On-Going Journey … ” Exploring Views From Staff Members On The Quality And Cultural Security Of Services For Aboriginal Families In Western Australia, Lina Gubhaju, Robyn Williams, Jocelyn Jones, David Hamer, Carrington Shepherd, Dan Mcaullay, Sandra J. Eades, Bridgette Mcnamara

Research outputs 2014 to 2021

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Cultural security is a key element of accessible services for Indigenous peoples globally, although few studies have examined this empirically. We explored the scope, reach, quality, and cultural security of health and social services available to Aboriginal and/or Torres Strait Islander families in Western Australia (WA), from the point of view of staff from the services. We recruited staff from health and social services for Aboriginal people in the Perth, Kalgoorlie, Great Southern, and South West regions of WA between December 2015 and September 2017 to complete online surveys. We examined …

Perceived Influence Of Value Systems On The Uptake Of Voluntary Medical Male Circumcision Among Men In Kweneng East, Botswana, Thandisizwe R. Mavundla, Fungai Mbengo, Khanyenda Bruce Ngomi

Research outputs 2014 to 2021

© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Botswana is one of the countries in Eastern and Southern Africa significantly impacted by the Human Immunodeficiency Virus (HIV). To control the spread of HIV, the government in 2009 rolled out the voluntary medical male circumcision (VMMC) programme as an additional HIV prevention strategy with the goal of circumcising 80% of HIV negative men by 2016. However, the country failed to achieve this goal as less than 30% of the targeted men were circumcised by 2016. A study was therefore conducted to explore and describe …

One-Year Outcome And Adherence To Pharmacological Guidelines In First-Episode Schizophrenia: Results From A Consecutive Cohort Study, Petros Drosos, Kolbjørn Brønnick, Inge Joa, Jan Olav Johannessen, Erik Johnsen, Rune Andreas Kroken, Helen Joy Stain, Wenche Ten Velden Hegelstad, Tor Ketil Larsen

Research outputs 2014 to 2021

© Wolters Kluwer Health, Inc. All rights reserved. Background Remission in schizophrenia is difficult to achieve. Antipsychotic drugs are critical in the treatment of schizophrenia. International guidelines for the pharmacological treatment of schizophrenia recommend a 3-step algorithm with clozapine being the third-line antipsychotic agent. This study investigated the 1-year outcome and the application of the guidelines for the pharmacological treatment of nonremitted first-episode schizophrenia (FES) patients during the first year of follow-up. Methods A sample of 78 FES patients from the Norwegian TIPS (Early Treatment and Intervention in Psychosis) 2 study was assessed at the end of the first year …

Broad Spectrum Epidemiological Contribution Of Cannabis And Other Substances To The Teratological Profile Of Northern New South Wales: Geospatial And Causal Inference Analysis, Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2014 to 2021

© 2020, The Author(s). Background: Whilst cannabis commercialization is occurring rapidly guided by highly individualistic public narratives, evidence that all congenital anomalies (CA) increase alongside cannabis use in Canada, a link with 21 CA’s in Hawaii, and rising CA’s in Colorado indicate that transgenerational effects can be significant and impact public health. It was therefore important to study Northern New South Wales (NNSW) where cannabis use is high. Methods: Design: Cohort. 2008–2015. Setting: NNSW and Queensland (QLD), Australia. Participants. Whole populations. Exposures. Tobacco, alcohol, cannabis. Source: National Drug Strategy Household Surveys 2010, 2013. Main Outcomes. CA Rates. NNSW-QLD comparisons. Geospatial …

Interpreting Health Events In Big Data Using Qualitative Traditions, Roschelle L. Fritz, Gordana Dermody

Research outputs 2014 to 2021

© The Author(s) 2020. The training of artificial intelligence requires integrating real-world context and mathematical computations. To achieve efficacious smart health artificial intelligence, contextual clinical knowledge serving as ground truth is required. Qualitative methods are well-suited to lend consistent and valid ground truth. In this methods article, we illustrate the use of qualitative descriptive methods for providing ground truth when training an intelligent agent to detect Restless Leg Syndrome. We show how one interdisciplinary, inter-methodological research team used both sensor-based data and the participant’s description of their experience with an episode of Restless Leg Syndrome for training the intelligent agent. …

Reply To Lipworth Et Al., Angela M. Moran, Sanjay Ramakrishnan, Catherine A. Borg, Clare M. Connolly, Simon Couillard, Christine M. Mwasuku, Ian D. Pavord, Timothy S.C. Hinks, Lauri Lehtimӓki

Research outputs 2014 to 2021

We thank Dr. Lipworth and colleagues for their interest in our work published recently in the Journal (1). They rightly point out that the biology of asthma attacks is more complex than blood eosinophils alone and that corticosteroids have a wide range of other potentially relevant antiinflammatory effects. However, local treatment with inhaled corticosteroids (ICS) is usually the mainstay of patients with frequent eosinophilic exacerbations, and therefore in the great majority of patients, the key question is what oral corticosteroids (OCS) add to ICS in an acute attack (2) and whether this effect is seen with benralizumab. We suggest that …

Pilot Study On The Reliability Of The Coach's Eye: Identifying Talent Throughout A 4-Day Cadet Judo Campp, Alexandra H. Roberts, Daniel Greenwood, Clare Humberstone, Annette J. Raynor

Research outputs 2014 to 2021

A typical assumption found in talent identification literature is that different coaches, given the same athletes and circumstances, will identify the same subset of athletes as “talented”. However, while coaches play a major role during talent identification in practical sport settings, there is limited empirical research exploring the processes which underpin this. The purpose of this study was to explore the reliability of “the coach's eye” during the assessment of talent in a group of athletes. Specifically, this project compared inter-coach agreement between nine judo coaches (ages 35.8 ± 10.6 years) with varying levels of experience (12.9 ± 8.9 years) …

External Barriers For Including Parents Of Preterm Infants In A Randomised Clinical Trial In The Neonatal Intensive Care Unit In Sweden: A Descriptive Study, Evalotte Mörelius, Emma Olsson, Charlotte Sahlén Helmer, Ylva Thernström Blomqvist, Charlotte Angelhoff

Research outputs 2014 to 2021

© Author(s) (or their employer(s)) 2020. Objectives Performing randomised controlled trials (RCTs) in neonatal intensive care is challenging in many ways. While restrictive inclusion criteria or busy study protocols are obvious barriers, external barriers leading to termination of a study are seldom discussed. The aim of this study was to describe barriers for inclusion of families in neonatal intensive care in an RCT aiming to evaluate the effects of continuous skin-to-skin contact on mood and sleep quality in parents of preterm infants, as well as the quality of parent-infant interaction and salivary cortisol concentrations at the time of discharge. Design …

An Intervention With Dance And Yoga For Girls With Functional Abdominal Pain Disorders (Just In Time): Protocol For A Randomized Controlled Trial, Anna Philipson, Stefan Särnblad, Lars Ekstav, Mats Eriksson, Ulrika L. Fagerberg, Margareta Möller, Evalotte Mörelius, Anna Duberg

Research outputs 2014 to 2021

©Anna Philipson, Stefan Särnblad, Lars Ekstav, Mats Eriksson, Ulrika L Fagerberg, Margareta Möller, Evalotte Mörelius, Anna Duberg. Background: Functional abdominal pain disorders (FAPDs) affect many children worldwide, predominantly girls, and cause considerable long-term negative consequences for individuals and society. Evidence-based and cost-effective treatments are therefore strongly needed. Physical activity has shown promising effects in the practical management of FAPDs. Dance and yoga are both popular activities that have been shown to provide significant psychological and pain-related benefits with minimal risk. The activities complement each other, in that dance involves dynamic, rhythmic physical activity, while yoga enhances relaxation and focus. Objective: …

Evaluation Of A Remote Symptom Assessment And Management (Sam) System For People Receiving Adjuvant Chemotherapy For Breast Or Colorectal Cancer: Mixed Methods Study, Lisa Whitehead, Laura Emery, Deborah Kirk, Diane Twigg, Deborah Brown, Joanna Dewar

Research outputs 2014 to 2021

©Lisa Whitehead, Laura Emery, Deborah Kirk, Diane Twigg, Deborah Brown, Joanna Dewar. Background: The Symptom Assessment and Management (SAM) program is a structured, online, nurse-supported intervention to support symptom self-management in people receiving adjuvant chemotherapy post surgery for breast or colorectal cancer. Objective: The objective of this study was to describe the development, implementation strategy, and evaluation of the SAM system. Methods: The development of the SAM program involved 3 phases. In phase 1, the web app was developed through consultation with consumers and clinicians and of the literature to ensure that the system was evidence-based and reflected the realities …

Brainwave Nets: Are Sparse Dynamic Models Susceptible To Brain Manipulation Experimentation?, Diego C. Nascimento, Marco A. Pinto-Orellana, Joao P. Leite, Dylan J. Edwards, Francisco Louzada, Taiza E.G. Santos

Research outputs 2014 to 2021

© Copyright © 2020 Nascimento, Pinto-Orellana, Leite, Edwards, Louzada and Santos. Sparse time series models have shown promise in estimating contemporaneous and ongoing brain connectivity. This paper was motivated by a neuroscience experiment using EEG signals as the outcome of our established interventional protocol, a new method in neurorehabilitation toward developing a treatment for visual verticality disorder in post-stroke patients. To analyze the [complex outcome measure (EEG)] that reflects neural-network functioning and processing in more specific ways regarding traditional analyses, we make a comparison among sparse time series models (classic VAR, GLASSO, TSCGM, and TSCGM-modified with non-linear and iterative optimizations) …

The Prognostic Impact Of Circulating Tumour Dna In Melanoma Patients Treated With Systemic Therapies—Beyond Braf Mutant Detection, Gabriela Marsavela, Peter A. Johansson, Michelle R. Pereira, Ashleigh C. Mcevoy, Anna L. Reid, Cleo Robinson, Lydia Warburton, Muhammad A. Khattak, Tarek M. Meniawy, Benhur Amanuel, Michael Millward, Nicholas K. Hayward, Melanie R. Ziman, Elin S. Gray, Leslie Calapre

Research outputs 2014 to 2021

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. In this study, we evaluated the predictive value of circulating tumour DNA (ctDNA) to inform therapeutic outcomes in metastatic melanoma patients receiving systemic therapies. We analysed 142 plasma samples from metastatic melanoma patients prior to commencement of systemic therapy: 70 were treated with BRAF/MEK inhibitors and 72 with immunotherapies. Patient-specific droplet digital polymerase chain reaction assays were designed for ctDNA detection. Plasma ctDNA was detected in 56% of patients prior to first-line anti-PD1 and/or anti-CTLA-4 treatment. The detection rate in the immunotherapy cohort was comparably lower than those with BRAF inhibitors …

Factors Influencing Weight Loss Practices In Italian Boxers: A Cluster Analysis, Stefano Amatori, Oliver R. Barley, Erica Gobbi, Diego Vergoni, Attilio Carraro, Carlo Baldari, Laura Guidetti, Marco B.L. Rocchi, Fabrizio Perroni, Davide Sisti

Research outputs 2014 to 2021

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. It is common practice in combat sports that athletes rapidly lose body weight before a match, by applying different practices—some safer and others possibly dangerous. The factors behind the choice of practices utilised have not been fully studied. This study aimed to investigate the weight loss strategies used by Italian boxers and to look at the difference between higher and lower risk practice adaptors. A modified version of a validated questionnaire has been sent to 164 amateur (88%) and professional (12%) boxers by email. A heatmap with hierarchical clustering was used …

Impact Of A Multimodal Exercise Program On Tibial Bone Health In Adolescents With Development Coordination Disorder: An Examination Of Feasibility And Potential Efficacy, Jocelyn L. Tan, Aris Siafarikas, Timo Rantalainen, Nicolas H. Hart, Fleur Mcintyre, Beth Hands, Paola Chivers

Research outputs 2014 to 2021

© 2020, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved. Objectives: Developmental coordination disorder (DCD) compromises bone health purportedly due to lower levels of physical activity. The potential of an exercise intervention to improve bone health parameters in adolescents with DCD has not previously been studied. This study thus aimed to determine the impact of a multimodal exercise intervention on bone health in this population at-risk of secondary osteoporosis. Methods: Twenty-eight adolescents (17 male, 11 female) aged between 12-17 years (Mage =14.1) with DCD participated in a twice weekly, 13-week generalised multimodal exercise intervention. Peripheral quantitative computed tomography …