Medicine and Health Sciences Commons^™

Amylin And Beta Amyloid Proteins Interact To Form Amorphous Heterocomplexes With Enhanced Toxicity In Neuronal Cells, Prashant Bharadwaj, Tanya Solomon, Bikash Sahoo, Katarzyna Ignasiak, Scott Gaskin, Joanne Rowles, Guiseppe Verdile, Mark Howard, Charles S. Bond, Ayyalusamy Ramamoorthy, Ralph Martins, Philip Newsholme

Research outputs 2014 to 2021

Human pancreatic islet amyloid polypeptide (hIAPP) and beta amyloid (Aβ) can accumulate in Type 2 diabetes (T2D) and Alzheimer’s disease (AD) brains and evidence suggests that interaction between the two amyloidogenic proteins can lead to the formation of heterocomplex aggregates. However, the structure and consequences of the formation of these complexes remains to be determined. The main objective of this study was to characterise the different types and morphology of Aβ-hIAPP heterocomplexes and determine if formation of such complexes exacerbate neurotoxicity. We demonstrate that hIAPP promotes Aβ oligomerization and formation of small oligomer and large aggregate heterocomplexes. Co-oligomerized Aβ42-hIAPP mixtures …

Cross-Sectional Survey Of Sleep Practices Of Australian University Students, Rachel Batten, Katrina Liddiard, Annette J. Raynor, Cary A. Brown, Mandy Stanley

Research outputs 2014 to 2021

Background and Aim: Sleep insufficiency is often associated with the life of a university student, yet it is well known that inadequate sleep can have a negative impact on physical and mental health and be detrimental to cognitive skills for learning. The aim of this study was to replicate a Canadian study to survey university student sleep practices, the way in which students address any sleep issues, and the students’ preferred method to receive targeted sleep information. Methods: An anonymous on-line survey was promoted to all enrolled students at one Australian University in August 2017. Results: In total, 601 students …

Pilot Service Evaluation Of A Brief Psychological Therapy For Self-Harm In An Emergency Department: Hospital Outpatient Psychotherapy Engagement Service, Peter J. Taylor, Kirsten Fien, Helen Mulholland, Rui Duarte, Joanne M. Dickson, Cecil Kullu

Research outputs 2014 to 2021

© 2020 The Authors. Psychology and Psychotherapy: Theory, Research and Practice published by John Wiley & Sons Ltd on behalf of British Psychological Society Background: Brief psychological therapies may be helpful for people who have recently self-harmed. The current paper reports on a service evaluation of a novel brief therapy service based within an Emergency Department, Hospital Outpatient Psychotherapy Engagement (HOPE) Service. This service combines elements of psychodynamic interpersonal and cognitive analytic therapy to help people who present with self-harm-related difficulties. The primary aim of this service evaluation was to ascertain the feasibility of HOPE in terms of attendance rates. …

Mental Distress And Quality Of Life Following Provision Of Vascular Imaging Results Of The Coronary And Carotid Arteries To Asymptomatic Adults: A Scoping Review Protocol, Reindolf Anokye, Ben Jackson, James Dimmock, Joanne M. Dickson, Lauren C. Blekkenhorst, Jonathan M. Hodgson, Joshua Lewis, Mandy Stanley

Research outputs 2014 to 2021

Background: Non-invasive screening for atherosclerosis or asymptomatic cardiovascular disease of the coronary and carotid arteries is commonly undertaken, and research has been focussed on how results from these screenings lead to behaviour change. However, no review has focused on the effects of these results on mental distress and quality of life. This protocol will outline how a scoping review will be conducted to map all available evidence on mental distress or quality of life outcomes following the provision of vascular imaging results of the coronary and carotid arteries.

Methods: Arksey and O’Malley’s (2005) framework will guide the scoping review. Databases …

Recognition And Management Of Agitation In Acute Mental Health Services: A Qualitative Evaluation Of Staff Perceptions, Joshua Tucker, Lisa Whitehead, Peter Palamara, Josephine Xenia Rosman, Karla Seaman

Research outputs 2014 to 2021

© 2020, The Author(s).

Background: Agitation among patients is a common and distressing behaviour across a variety of health care settings, particularly inpatient mental health. Unless recognised early and effectively managed it can lead to aggression and personal injury. The aim of this paper is to explore the experiences of mental health nurses in recognising and managing agitation in an inpatient mental health setting and the alignment of these experiences with best practice and person-centred care.

Methods: This study used a descriptive qualitative methodology. Semi-structured focus group interviews were conducted with 20 nurses working in a mental health unit in …

Remodeling The Skeletal Muscle Extracellular Matrix In Older Age—Effects Of Acute Exercise Stimuli On Gene Expression, Matthias Gumpenberger, Barbara Wessner, Alexandra Graf, Marco V. Narici, Christian Fink, Sepp Braun, Christian Hoser, Anthony J. Blazevich, Robert Csapo

Research outputs 2014 to 2021

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. With advancing age, the skeletal muscle extracellular matrix (ECM) undergoes fibrotic changes that may lead to increased muscle stiffness, injury susceptibility and strength loss. This study tested the potential of different exercises to counter these changes by stimulating the activity of genes associated with ECM remodeling. Twenty-six healthy men (66.9 ± 3.9 years) were stratified to two of four groups, performing unilateral (i) conventional resistance exercise, (ii) conventional resistance exercise followed by self-myofascial release (CEBR), (iii) eccentric-only exercise (ECC) or (iv) plyometric jumps (PLY). The non-trained leg served as control. Six …

Combination Of Ct And Rt-Pcr In The Screening Or Diagnosis Of Covid-19, Youxin Wang, Haifeng Hou, Wenrui Wang, Wei Wang

Research outputs 2014 to 2021

[No abstract available]

A Whole-School Approach To Promoting Staff Wellbeing, Leanne Lester, Carmel Cefai, Valeria Cavioni, Amy Barnes, Donna Cross Professor

Australian Journal of Teacher Education

A caring school community can enhance whole-school wellbeing including the wellbeing of school staff, which directly impacts on student academic, social and emotional wellbeing. This study firstly examines the validity and reliability of a proposed whole-school staff wellbeing evaluation tool which uses a set of whole-school wellbeing indicators to identify strengths and areas for improvement within the school environment which may be impacting on staff wellbeing. Secondly, the association between factors found within the whole-school staff wellbeing tool with staff self-reported mental health are examined, and finally, the influence of person characteristics and role of factors on perceived whole-school staff …

Contemporary Epidemiology Of Rising Atrial Septal Defect Trends Across Usa 1991-2016: A Combined Ecological Geotemporospatial And Causal Inferential Study, Albert Stuart Reece

Research Datasets

Background: Cardiovascular anomalies are the largest group of congenital anomalies and the major cause of death in young children, with a range of data linking rising atrial septal defect incidence (ASDI) with prenatal cannabis exposure. Objectives / Hypotheses. Is cannabis associated with ASDI in USA? Is this relationship causal?

Methods: Geospatiotemporal cohort study, 1991-2016. Census populations of adults, babies, congenital anomalies, income and ethnicity. Drug exposure data on cigarettes, alcohol abuse, past month cannabis use, analgesia abuse and cocaine taken from National Survey of Drug Use and Health (78.9% response rate). Cannabinoid concentrations from Drug Enforcement Agency. Inverse probability weighted …

A Geospatiotemporal And Causal Inference Epidemiological Exploration Of Substance And Cannabinoid Exposure As Drivers Of Rising Us Pediatric Cancer Rates, Albert Stuart Reece

Research Datasets

Background: Age-adjusted US total pediatric cancer incidence rates (TPCIR) rose 49% 1975-2015 for unknown reasons. Prenatal cannabis exposure has been linked with several pediatric cancers which together comprise the majority of pediatric cancer types. We investigated whether cannabis use was related spatiotemporally and causally to TPCIR.

Methods: State-based age-adjusted TPCIR data was taken from the CDC Surveillance, Epidemiology and End Results cancer database 2003-2017. Drug exposure was taken from the nationally-representative National Survey of Drug Use and Health, response rate 74.1%. Drugs included were: tobacco, alcohol, cannabis, opioid analgesics and cocaine. This was supplemented by cannabinoid concentration data from the …

Broad Spectrum Epidemiological Contribution Of Cannabis, Tobacco And Alcohol To The Teratological Profile Of Northern New South Wales: Geospatial And Causal Inference Analysis, Albert Stuart Reece

Research Datasets

Background: Whilst cannabis commercialization is occurring rapidly guided by highly individualistic public narratives, evidence that all congenital anomalies (CA) increase alongside cannabis use in Canada, a link with 21 CA’s in Hawaii, and rising CA’s in Colorado indicate that transgenerational effects can be significant and impact public health. It was therefore important to study Northern New South Wales (NNSW) a known cannabis use centre.

Methods: Design: Cohort. 2008-2015. Setting: NNSW and Queensland (QLD), Australia. Participants. Whole populations. Exposures. Tobacco, Risky Alcohol, Annual cannabis. Source: National Drug Strategy Household Surveys 2010, 2013. Main Outcomes. CA Rates. NNSW-QLD comparisons. Geospatial and causal …

Co-Occurrence Across Time And Space Of Drug- And Cannabinoid- Exposure And Adverse Mental Health Outcomes In The National Survey Of Drug Use And Health Dataset 2: Combined Ecological Geotemporospatial And Causal Inference Analysis, Albert Stuart Reece

Research Datasets

Background: Whilst many studies have linked increased drug and cannabis exposure to adverse mental health (MH) outcomes their effects on whole populations and geotemporospatial relationships are not well understood.

Objectives: Determine: (1) if cannabis use is associated with major MH outcomes ascross space and time, (2) if such impacts are robust to multivariable adjustment and (3) if the relationship is causal.

Methods: Ecological cohort study of National Survey of Drug Use and Health (NSDUH) geographically-linked substate-shapefiles 2010-2012 and 2014-2016 supplemented by five-year US American Community Survey. Drugs: cigarettes, alcohol abuse, last-month cannabis use and last-year cocaine use. MH: any mental …

Ecu-Ioht, Mohiuddin Ahmed, Surender Byreddy, Anush Nutakki, Leslie F. Sikos, Paul Haskell-Dowland

Research Datasets

In recent times, cyberattacks on Internet of Health Things (IoHT) have continuously been growing, and so it is important to develop robust countermeasures. However, there is a lack of publicly available datasets reflecting cyberattacks on IoHT, mainly due to privacy concerns. To strengthen the cyber security of IoHT, we have developed the dataset, named ECU-IoHT, that is built upon an IoHT environment having different attacks performed that exploit various vulnerabilities. This dataset was designed to help the healthcare security community in analyzing attack behaviour and developing robust countermeasures. To the best of our knowledge, no other publicly available datasets have …

Prostate Cancer Survivorship Essentials Framework: Guidelines For Practitioners, Jeff Dunn, Anna Green, Nicholas Ralph, Robert U. Newton, Andrew Kneebone, Mark Frydenberg, Suzanne K. Chambers

Research outputs 2014 to 2021

© 2020 The Authors BJU International © 2020 BJU International Published by John Wiley & Sons Ltd Objective: To develop contemporary and inclusive prostate cancer survivorship guidelines for the Australian setting. Participants and Methods: A four-round iterative policy Delphi was used, with a 47-member expert panel that included leaders from key Australian and New Zealand clinical and community groups and consumers from diverse backgrounds, including LGBTQIA people and those from regional, rural and urban settings. The first three rounds were undertaken using an online survey (94–96% response) followed by a fourth final face-to-face panel meeting. Descriptors for men’s current prostate …

Are Negative Beliefs About Psychosis Associated With Emotional Distress In Adults And Young People With Such Experiences? A Meta-Analysis, Esmira Ropaj, Andrew Jones, Joanne Dickson, Zabina Gill, Peter J. Taylor

Research outputs 2014 to 2021

© 2020 The Authors. Psychology and Psychotherapy: Theory, Research and Practice published by John Wiley & Sons Ltd on behalf of British Psychological Society Objective: Emotional distress, including depression and anxiety, is commonly reported amongst individuals experiencing psychosis. The beliefs individuals hold about the meaning of their psychosis may explain the distress they experience. The current meta-analysis aimed to review the association between beliefs about psychosis experiences and emotional distress. Method: Three electronic databases (PsycINFO, MEDLINE, and CINAHL) were searched using keywords and controlled vocabulary (e.g., Medical Subject Headings) from date of inception to August 2019. A total of 19 …

Clinical Oncology Society Of Australia: Position Statement On Cancer-Related Malnutrition And Sarcopenia, Nicole Kiss, Jenelle Loeliger, Merran Findlay, Elizabeth Isenring, Brenton J. Baguley, Anna Boltong, Alexis Butler, Irene Deftereos, Michelle Eisenhuth, Steve F. Fraser, Rebecca Fichera, Hayley Griffin, Sandi Hayes, Emily Jeffery, Catherine Johnson, Chris Lomma, Barbara Van Der Meij, Carolyn Mcintyre, Tracey Nicholls, Lina Pugliano, Tina Skinner, Jane Stewart, Judy Bauer

Research outputs 2014 to 2021

© 2020 The Authors. Nutrition & Dietetics published by John Wiley & Sons Australia, Ltd on behalf of Dietitians Australia. This position statement describes the recommendations of the Clinical Oncology Society of Australia (COSA) regarding management of cancer-related malnutrition and sarcopenia. A multidisciplinary working group completed a review of the literature, focused on evidence-based guidelines, systematic reviews and meta-analyses, to develop recommendations for the position statement. National consultation of the position statement content was undertaken through COSA members. All people with cancer should be screened for malnutrition and sarcopenia in all health settings at diagnosis and as the clinical situation …

Marked Increase In Community-Associated Methicillin-Resistant Staphylococcus Aureus Infections, Western Australia, 2004-2018, Lauren E. Bloomfield, G. W. Coombs, S. Tempone, P. K. Armstrong

Research outputs 2014 to 2021

© 2020 World Scientific Publishing Company. This study presents enhanced surveillance data from 2004 – 2018 for all community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) specimens collected in Western Australia (WA), and describes the changing epidemiology over this period. A total of 57,557 cases were reviewed. Annual incidence rates increased from 86.2 cases per 100,000 population to 245.6 per 100,000 population (IRR = 2.9, CI95 2.7 – 3.0). The proportion of isolates carrying Panton-Valentine leukocidin (PVL)-associated genes increased from 3.4% to 59.8% (χ2 test for trend 7021.9, p0.001). The emergence of PVL-positive, “Queensland CA-MRSA” (ST93- IV) and “WA 121” (ST5-IV) accounted for …

Chronic Kidney Disease Of Unknown Origin Is Associated With Environmental Urbanisation In Belfast, Uk, Jennifer M. Mckinley, Ute Mueller, Peter M. Atkinson, Ulrich Ofterdinger, Siobhan F. Cox, Rory Doherty, Damian Fogarty, J. J. Egozcue, V. Pawlowsky-Glahn

Research outputs 2014 to 2021

© 2020, The Author(s). Chronic kidney disease (CKD), a collective term for many causes of progressive renal failure, is increasing worldwide due to ageing, obesity and diabetes. However, these factors cannot explain the many environmental clusters of renal disease that are known to occur globally. This study uses data from the UK Renal Registry (UKRR) including CKD of uncertain aetiology (CKDu) to investigate environmental factors in Belfast, UK. Urbanisation has been reported to have an increasing impact on soils. Using an urban soil geochemistry database of elemental concentrations of potentially toxic elements (PTEs), we investigated the association of the standardised …

Increased Fascicle Length But Not Patellar Tendon Stiffness After Accentuated Eccentric-Load Strength Training In Already-Trained Men, Simon Walker, Joanne Trezise, Guy Gregory Haff, Robert U. Newton, Keijo Häkkinen, Anthony J. Blazevich

Research outputs 2014 to 2021

© 2020, The Author(s). Purpose: This study examined whether additional external load during the eccentric phase of lower limb strength training exercises led to greater adaptations in knee extensor strength, muscle architecture, and patellar tendon properties than traditional concentric–eccentric training in already-trained men. Methods: Twenty-eight men accustomed to strength training were randomized to undertake 10 weeks of supervised traditional (TRAD) or accentuated eccentric loading (AEL) or continue their habitual unsupervised (CON) strength training. TRAD and AEL trained 2∙week−1 with a six-repetition maximum (RM) session and a ten-RM session. TRAD used the same external load in both concentric and eccentric phases, …

Are Current Clinical Guidelines On The Use Of Peripheral Intravenous Cannula For Blood Draws Supported By Evidence? An Organizational Case Study, Alycia Jacob, Linda Coventry, Hugh Davies, Elisabeth Jacob

Research outputs 2014 to 2021

© 2020 The Authors. Nursing Open published by John Wiley & Sons Ltd Aim: To examine the quality of evidence used to inform health policies. Policies on peripheral intravenous cannulas were used as exemplars. Design: An organizational case study design was used, using the STROBE reporting guidelines. Methods: Policy guidelines were sourced between June and September 2018 from health departments in Australia. Seven documents were compared regarding intravenous cannula dwell times and blood collection use. Evidence used in the documents was critiqued using assessment guideline from the Oxford Centre for Evidence Based Medicine. Results: Large variations exist between policies regarding …

Confirmatory Factor Analysis And Reliability Of The Diabetes Treatment Satisfaction Questionnaire (Dtsq) For Arabic Speaking Patients With Type Ii Diabetes, Diana Arabiat, Lisa Whitehead, Buthina Abu Sheikh, Ebenezer Afrifa-Yamoah

Research outputs 2014 to 2021

Background: Treatment satisfaction is an important indicator for treatment compliance and glycemic control. Although psychometric properties of the Diabetes Treatment Satisfaction Questionnaire have been confirmed in several languages, it remains unclear the extent to which the factorial structure of this tool is valid for Arabic speaking populations.

Purpose: This study set out to confirm the construct validity of the Arabic version of the Diabetes Treatment Satisfaction Questionnaire (DTSQ) by investigating the fit of published factor structures and the reliability of responses in patients diagnosed with type 2 diabetes.

Methods: Data were from a large cross-sectional study of 1002 patients with …

Lower-Body Power, Linear Speed, And Change-Of-Direction Speed In Division I Collegiate Women's Volleyball Players, Robert G. Lockie, J. Jay Dawes, Samuel J. Callaghan

Research outputs 2014 to 2021

© 2020 Institute of Sport. All rights reserved. Volleyball players need to sprint and change direction during a match. Lower-body power, often measured by jump tests, could contribute to faster movements. How different jumps relate to linear and change-of-direction (COD) speed has not been analyzed in Division I (DI) collegiate women's volleyball players. Fifteen female volleyball players completed the vertical jump (VJ), two-step approach jump (AppJ), and standing broad jump (SBJ). Peak power and power-to-body mass ratio (P:BM) were derived from VJ and AppJ height; relative SBJ was derived from SBJ distance. Linear speed was measured via a 20-m sprint …

South West Food Community: Understanding Systemic Change, And Its Associated Challenges And Successes, Among Food Security Projects, Johanna Rewa, Amanda Devine, Stephanie Godrich

Research outputs 2014 to 2021

Objective: The South West Food Community (SWFC) project (2018) aimed to identify initiatives working to support food security in the South West region of Western Australia, and to enhance how these initiatives functioned as a system. The SWFC project used a Systemic Innovation Lab approach that, prior to this study, had not been evaluated. This evaluation aimed to: i) measure system transitions (changes) to initiatives; and ii) understand the challenges and successes associated with system transitions.

Methods: SWFC initiative leaders (n=46) such as directors, managers or coordinators, volunteers or committee members were invited to participate in this evaluation. …

Summary Of Kidney Health Among Aboriginal And Torres Strait Islander People, Australian Indigenous Healthinfonet

Research outputs 2014 to 2021

No abstract provided.

Understanding The “Gut Instinct” Of Expert Coaches During Talent Identification, Alexandra H. Roberts, Daniel Greenwood, Mandy Stanley, Clare Humberstone, Fiona Iredale, Annette Raynor

Research outputs 2014 to 2021

Coaches are an integral part of talent identification in sport and are often used as the “gold standard” against which scientific methods of talent identification are compared. However, their decision-making during this process is not well understood. In this article, we use an ecological approach to explore talent identification in combat sports. We interviewed twenty-four expert, international-level coaches from the Olympic disciplines of boxing, judo, and taekwondo (age: 48.7 + 7.5 years; experience: 20.8 + 8.3 years). Findings indicated that when coaches identify talent they rely on “gut instinct”: intuitive judgements made without conscious thought, used to direct attention to …

Reviewing The Current Methods Of Assessing Hydration In Athletes, Oliver R. Barley, Dale W. Chapman, Chris R. Abbiss

Research outputs 2014 to 2021

Background

Despite a substantial body of research, no clear best practice guidelines exist for the assessment of hydration in athletes. Body water is stored in and shifted between different sites throughout the body complicating hydration assessment. This review seeks to highlight the unique strengths and limitations of various hydration assessment methods described in the literature as well as providing best practice guidelines.

Main body

There is a plethora of methods that range in validity and reliability, including complicated and invasive methods (i.e. neutron activation analysis and stable isotope dilution), to moderately invasive blood, urine and salivary variables, progressing to non-invasive …

Can Exercise Adaptations Be Maintained In Men With Prostate Cancer Following Supervised Programmes? Implications To The Covid-19 Landscape Of Urology And Clinical Exercise, Pedro Lopez, Dennis R. Taaffe, Robert U. Newton, Nigel Spry, Tom Shannon, Mark Frydenberg, Fred Saad, Daniel A. Galvão

Research outputs 2014 to 2021

© 2020 The Author(s) In this brief correspondence, we evaluate the potential impact of pivoting from face-to-face supervised to unsupervised home-based exercise programmes to contextualise the coronavirus disease 2019 (COVID-19) pandemic in prostate cancer patients. A meta-analysis was undertaken in fatigue, quality of life, and lean and fat mass outcomes in the four studies included. Our analysis indicates that unsupervised home-based exercise maintains patient-reported outcomes, except for fat mass. In summary, changing to unsupervised exercise is unlikely to provide further benefits on patient-reported and body composition outcomes, but may help maintain initial gains during physical distancing restrictions. Patient summary: We …

Correlations Between Covid-19 Case Growth And Mental Health-Related Internet Search: An Unexpected Finding, Tenghao (Nick) Zhang

Research outputs 2014 to 2021

At the time of writing, the number of global con-firmed COVID-19 cases has topped 18.8 million with over 707,000 deaths (1). The Internet plays a pivotal role during this unprecedented pandemic (2,3) in the way that people predominantly use the Internet to contact each other and acquire information due to sweeping stay-at-home orders and strict lockdown restrictions imposed by au-thorities around the world. Health-related mental health issues could lead to spikes in online infor-mation search (4, 5). Therefore, this letter aims to investigate whether the rise of regional COVID cases is correlated with the increase in residents’ online searches of …

Addressing The Confusion Within Periodization Research, W. Guy Hornsby, Andrew C. Fry, G. Gregory Haff, Michael H. Stone

Research outputs 2014 to 2021

© 2020 by the authors. In this editorial, we focus on recent problematic developments in sport science, and more specifically, problems related to periodization research. Primary areas discussed are (1) appreciation of history, (2) considerations for training studies, (3) the development of concepts, and (4) programming-driven training models.

Detection Of Braf Splicing Variants In Plasma-Derived Cell-Free Nucleic Acids And Extracellular Vesicles Of Melanoma Patients Failing Targeted Therapy Therapies, Michael E. Clark, Helen Rizos, Michelle Pereira, Ashleigh Mcevoy, Gabriela Marsavela, Leslie Calapre, Katie Meehan, Olivia Ruhen, Muhammad A. Khattak, Tarek M. Meniawy, Georgina Long, Matteo S. Carlino, Alexander M. Menzies, Michael Millward, Melanie Ziman, Elin S. Gray

Research outputs 2014 to 2021

The analysis of plasma circulating tumour nucleic acids provides a non-invasive approach to assess disease burden and the genetic evolution of tumours in response to therapy. BRAF splicing variants are known to confer melanoma resistance to BRAF inhibitors. We developed a test to screen cell-free RNA (cfRNA) for the presence of BRAF splicing variants. Custom droplet digital PCR assays were designed for the detection of BRAF splicing variants p61, p55, p48 and p41 and then validated using RNA from cell lines carrying these variants. Evaluation of plasma from patients with reported objective response to BRAF/MEK inhibition followed by disease progression …