Medicine and Health Sciences Commons^™

Does Relevant Work Experience Influence Academic Success? A Retrospective Study Of Doctor Of Physical Therapy Students, Nicole Tombers, Kate Corrigan, Rylee Kwiatkowski, Gwinna Remillard, Morgan Scanlon, Maddy Soderberg

Internet Journal of Allied Health Sciences and Practice

Purpose: Relevant work experience is a factor considered in holistic admissions practices of many health profession education programs. The benefits of observation hours on student career choice and subsequent academic success have been explored. Many programs additionally consider paid work experience as a factor in admissions decisions; however the influence of relevant work experience on academic outcomes is unknown. This study examined relationships between paid physical therapy related work experience and performance in a DPT program. Method: Data from 945 applicants resulting in 191 matriculants to a single DPT program were included. Employment history for all applicants was coded as …

The Effect Of Debriefing Following A Computer-Based Low-Fidelity Simulation On The Self-Efficacy Of Health Professions Students: A Randomized Cross-Over Control Study, Matthew Mills, Enrico Gandolfi, Richard E. Ferdig, Kimberly Peer

Internet Journal of Allied Health Sciences and Practice

Purpose: Simulations have been increasingly used in health science education to supplement clinical experience. There is evidence of the benefits of high-fidelity simulation (HFS) with debriefing, but HFS is costly and time-intensive to administer. Low-fidelity simulation (LFS) has been proposed as an alternative that is easier to scale and more cost-effective; however, the evidence surrounding its impact on students is mixed, possibly because debriefing is frequently omitted in LFS. Methods: A randomized experimental mixed methods cross-over control study was performed to evaluate the impact of a structured debriefing session following an interactive computer-based low-fidelity simulation on the self-efficacy and anxiety …

What Numbers Don't Tell Us: Can Sociodemographic Factors Identify Grit, Resilience, And Imposter Phenomenon In Hybrid Doctor Of Physical Therapy Students?, Benton Lindaman, Marlena Calo, Brandon Ness, James Smoliga, Moyo B. Tillery, Suzanne Trotter, Liana Wooten, Shefali Christopher

Internet Journal of Allied Health Sciences and Practice

Purpose: To determine whether routinely collected sociodemographic admissions criteria (e.g., first-generation status, race, government assistance, youth employment) could serve as proxies for non-cognitive traits such as grit, resilience, and imposter phenomenon in hybrid Doctor of Physical Therapy (DPT) students. Method: A descriptive, cross-sectional survey was conducted among first-year students (N=100) across three accelerated, hybrid DPT programs. Students completed validated instruments measuring grit (Grit-O), general resilience (Brief Resilience Scale), academic resilience (Academic Resilience Scale), and imposter phenomenon (Clance Imposter Phenomenon Scale) during their first semester. Sociodemographic data were obtained from admissions applications. Between-group comparisons were analyzed using independent t-tests and …

Acquisition Of Basic Clinical Skills Among Japanese Novice Rehabilitation Therapists: A Retrospective Study, Kenta Fujimura, Hiroaki Sakurai, Soichiro Koyama, Kenji Kawakami, Kazuya Takeda, Takuma Ii, Shota Suzumura, Shigeo Tanabe, Yoshikiyo Kanada

Internet Journal of Allied Health Sciences and Practice

Purpose: This study examined the relationship between basic clinical skills and clinical experience among novice rehabilitation therapists in Japan. Methods: Twenty-one novice rehabilitation therapists who joined a general hospital and underwent annual practical examinations during each of their three years of clinical experience were included. This retrospective longitudinal single-center study followed the same novice therapists throughout the study period. The practical examination was based on the Objective Structured Clinical Examination (OSCE) and included exercises for joint range of motion (ROM), muscle strengthening (MS), getting up (Getting Up), standing up and sitting down (Standing/Sitting), and transferring from a wheelchair to a …

The Effect Of A Mindfulness-Based Program On Musculoskeletal Pain And Function, Christine Conroy, Kent E. Irwin, Paige Dougherty, Teresa Elliott-Burke

Internet Journal of Allied Health Sciences and Practice

Purpose: Mindfulness-based Stress Reduction (MBSR) is a structured therapeutic tool that was developed in the 1980s by Kabat-Zinn and colleagues. Mindfulness-based interventions (MBIs) have been developed based on the fundamental principles of MBSR and are an emerging area of research. These programs are used to decrease pain levels and kinesiophobia in patients with chronic disease and pain. The purpose of this case study is to describe the effects of MBIs on function and pain for a middle-aged patient, two-month post-proximal humerus fracture. Method: A 53-year-old woman presented status post closed fracture of the proximal right humerus resulting from a …

Institutional Prestige And Prerequisite Performance As Predictors Of Academic Success In Doctor Of Physical Therapy Programs: A Pilot Retrospective Cohort Study, Margaret Wicinski, Tamala Marcin

Internet Journal of Allied Health Sciences and Practice

Purpose: This pilot study examined relationships between Carnegie Classification levels of undergraduate institutions, prerequisite anatomy and physiology (AP) performance, and academic success in Doctor of Physical Therapy (DPT) education. Methods: This retrospective cohort study analyzed records from 83 students who graduated from a single DPT program in 2019. Data included Carnegie Classifications of prerequisite institutions, undergraduate anatomy and physiology grade point average (UGPA AP 1&2 GPA), first-term pathophysiology course grade (Patho GPA), and Doctor of Physical Therapy program grade point average (DPT GPA). Statistical analyses included Spearman rank order correlation (rs) and Kruskal-Wallis tests with effect size calculations. Power analysis …

Effectiveness Of Core Strengthening In The Treatment Of Chronic Low Back Pain: A Literature Review, Khalid G. Attia

Internet Journal of Allied Health Sciences and Practice

Purpose: Chronic low back pain (CLBP) is one of the leading causes of disability in the world. High levels of functional impairment, mental stress, and socioeconomic burdens usually accompany it. With the shift in paradigm to a non-pharmacological approach to management, core strengthening exercises have assumed a central role in the conservative approach to CLBP rehabilitation. Moreover, there is also the inclusion of complementary practices of yoga and Pilates, as well as new technologies in digital health, which has expanded the field of therapy The goals of this literature review are to review evidence of the effectiveness of core stabilization, …

Face And Content Validity Of A Survey Tool To Measure Perceived Barriers And Facilitators To Diabetes Management In Rural Veterans: Perspectives Of Registered Dietitians, Jameson Tade, Mary Shotwell, Ronette Lategan-Potgieter, Marty R. Jacobson

Internet Journal of Allied Health Sciences and Practice

Purpose: Type 2 diabetes mellitus (T2DM) is a major health challenge in the United States, affecting over 36 million Americans exceeding $105 billion annually in treatment-related costs.^1,2 Type 2 diabetes affects some populations more than others, including rural and veteran populations.^1,3 Registered dietitians (RDs) are an integral part of the diabetes management team, but limited literature is available to identify perceived barriers to T2DM management in military veterans who preside in rural areas. The purpose of this study was to explore face and content validity of a survey tool distributed to Veterans Health Administration (VHA) dietitians in a …

Exploring Hydration Strategies: A Preliminary Comparison Of Fluid Administration Methods In Collegiate Football Players, Emily E. Lodge, Gillian Romanchok, Isabella M. Farmer, Kimberly Schwabenbauer, Rich Patterson

Internet Journal of Allied Health Sciences and Practice

Introduction: Maintaining optimal hydration is critical for athletic performance and preventing heat-related illness, particularly among football players who face elevated risk due to heavy protective equipment and intense physical demands. As core body temperature and heart rate increases, physiological strain causes are directly correlated with the severity of body water deficit. Dehydration levels exceeding 2% of body weight significantly impair both aerobic performance capacity and cognitive ability. Purpose: Therefore, the purpose of this research is to investigate whether fluid consumption among collegiate football players differs based on administration methods (self-administration versus athletic trainer administration) during practice sessions. Methods: Twenty male …

The Phases Of Variation In Physiotherapy Management Of Organophosphate Poisoning Patients: A Case Series, Manish P. Shukla, Sachin A. Chaudhary, Hemant Deshpande, Nikita Gupta

Internet Journal of Allied Health Sciences and Practice

Purpose: Organophosphate (OP) poisoning presents a significant challenge in healthcare, with varying severities requiring adaptive management strategies. This case series examines the physiotherapy management of three patients with different levels of OP poisoning severity: mild, moderate and severe. The study highlights the crucial role of physiotherapy in the multidisciplinary care of OP poisoning patients and demonstrates the need for phase-specific interventions tailored to individual patient needs. Method: The severe case required prolonged mechanical ventilation and intensive care, with physiotherapy progressing from passive techniques to active mobilization over 15 days. The moderate case showed faster recovery, allowing for earlier initiation of …

Firearm Violence Prevention: Analysis Of Physical Therapy Political Action Committee Financial Contributions And Congressional Voting, Kim D. Dao, Edward P. Mulligan, Michael Siegel, Liana Wooten

Internet Journal of Allied Health Sciences and Practice

Purpose. The American Physical Therapy Association (APTA) declared firearm violence a public health crisis in 2019. This investigation aimed to understand relationships between the amount of APTA political action committee (PTPAC) donations received by a federal candidate and (1) their voting records on FV prevention legislation; and (2) their voting records on other APTA-supported legislation. Methods. Data pertaining to the identification and amount of PTPAC donations to federal Congressional candidates during the 2020 and 2022 election cycles were gathered from the public resource, Open Secrets. Public voting records were compiled on firearm and other APTA-supported legislation. Results. 222 candidates received …

The Sympathetic And Clinical Effects Of Dry Needling To The Thoracolumbar Junction Multifidi: A Randomized Controlled Trial, Nicole Clark, Cheryl J. Hill, Joshua Cleland, Thomas Massie, Shane Koppenhaver

Internet Journal of Allied Health Sciences and Practice

Purpose: The primary aim of this study was to investigate the neurophysiological effects of dry needling (DN) to the thoracolumbar junction multifidi when compared with a placebo. The secondary objective was to determine if there is a relationship between post-treatment pain and disability and the magnitude of sympathetic nervous system activity. Methods: Participants were eligible if they had low back pain, limited flexibility in at least one hamstring, and had not previously received DN. Participants completed the Numeric Pain Rating Scale and Oswestry Disability Index, underwent pressure pain threshold testing, and were randomized to a DN or sham …

Navigating Homelessness And Housing Accessibility: An Ethnography Of Guests At Operation Nightwatch, Chase Kawika Patton

Dissertations and Theses

In 2025, over 7,000 individuals in Portland, Oregon experiencing unsheltered homelessness are without access to shelter or transitional housing. In this resource gap Operation Nightwatch (ON) provides material support for people experiencing homelessness (PEH) in the University District neighborhood of downtown Portland. This study focused on the experiences of chronically homeless guests of Nightwatch as they navigated homelessness and housing access. The study relied on semi-structured interviews with staff and guests and on-site participant observation to determine the availability of support to access housing in a system governed by Coordinated Access and the Housing First model. Primary research took place …

Differences In Graft Rupture And Subsequent Meniscal Tears Following Adolescent Acl Reconstruction Using Quadriceps Tendon Versus Hamstrings Autograft: A Retrospective Study With Minimum 2-Year Follow-Up., Morgan E. Swanson, Christopher Defrancesco, Kevin M. Landrum, David Kell, Richa Gandhi, Sulagna Sarkar, Theodore J. Ganley, Kathleen J. Maguire

Department of Medicine Faculty Papers

BACKGROUND: Anterior cruciate ligament (ACL) reconstruction (ACLR) using quadriceps tendon (QT) autograft is associated with lower rates of graft rupture and favorable functional outcomes compared with hamstring (HS) autograft in adolescents. The ACL-deficient knee is at increased risk of injury to secondary stabilizers of the knee, including the menisci, although studies have not reported differences in rates of subsequent meniscal tear between HS and QT groups.

PURPOSE: The goal of this study was to compare rates of graft rupture and subsequent meniscal tear after adolescent ACLR using HS or QT autograft.

STUDY DESIGN: Cohort study; Level of evidence, 3.

METHODS: …

Clinical Validation Of Perfusion Imaging With Pulmonary Function Test Data Using Voronoi-Based Discretization, Jorge Cisneros, Caleb J. Herrera, Yi-Kuan Liu, Lisa V. Du, Yevgeniy Vinogradskiy, Richard Castillo, Girish Nair, Edward Castillo

Department of Medicine Faculty Papers

Objective.Accurate lung function assessment is essential for diagnosing and managing diseases like chronic obstructive pulmonary disorder, pulmonary emboli, and lung cancer. Single-photon emission computed tomography (SPECT) provides valuable 3D functional imaging of ventilation and perfusion, but is limited by low spatial resolution, availability, additional radiation, and cost. Alternative methods, including CT-based perfusion (CT-P) and deep learning models, require large datasets to validate results that are often scarce. Pulmonary function tests (PFTs) offer rapid and noninvasive global lung function measures and are clinically widely used. While ventilation correlates well with PFTs, perfusion imaging presents challenges due to complex blood flow and …

Cognitive And Emotional Conflict Control Among Children Affected By Parental Hiv/Aids In China, Huihui Wang, Juan Liu, Danfeng Wen, Wan Zhao, Xiaoming Li Ph.D., Junfeng Zhao

Faculty Publications

Background: Children affected by parental HIV/AIDS constitute a particularly vulnerable population, often facing heightened risks in psychosocial adaptation due to family disruption, social stigma, and resource deprivation. However, the characteristics of their executive functions, particularly the core component of conflict monitoring, remain unclear.

Methods: The present study compared the performance of children affected by parental HIV/AIDS (n=32) to a control group (n=32) on a cognitive conflict and emotional conflict face-word Stroop task.

Results: The results of the cognitive Stroop task demonstrated that both groups showed better performance in congruent stimuli compared to incongruent stimuli (86.20% vs.67.30%; 568.43ms vs.586.04ms). In the …

Tongue Reduction For Pediatric Obstructive Sleep Apnea: A Systematic Review., Adrian Williamson, Rohit Nallani, Jason R. Brown

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: Obstructive sleep apnea (OSA) is a prevalent pediatric disorder that, if untreated, can result in substantial developmental and health consequences. Tongue reduction procedures, such as midline posterior glossectomy (MPG), are increasingly used to address tongue base obstruction. This systematic review evaluates the effectiveness and safety of tongue reduction procedures for pediatric OSA.

DATA SOURCES: Embase, PubMed, and Web of Science databases were queried for studies from inception to September 20, 2023.

REVIEW METHODS: Studies reporting on outcomes of pediatric patients (≤21 years) undergoing tongue reduction surgery for OSA were included.

RESULTS: From 477 abstracts, 9 studies met the inclusion …

Exploring The Role Of Social Networks In Youth Mental Health, Nicholas Szoko, Alexander Riley, Jacquelin Rankine, Alison J Culyba

2020-Current year OA Pubs

Social network analysis (SNA) offers an innovative approach to understand youths' complex social support systems. Growing work highlights links between youths' social networks and mental health. We used SNA to examine associations between social network characteristics and psychological empowerment, depression, anxiety, and post-traumatic stress among youth living in areas with concentrated disadvantage. We administered egocentric social network surveys in which youth (i.e., egos) enumerated individuals in their social network (i.e., alters), answered questions about each alter, and described how alters were connected. We measured psychological empowerment and mental health symptoms with validated instruments. There were 111 youth in the analytic …

Sex-Related Differences In Clinical Profile, Management, And Outcomes Of Patients With Type A And B Acute Aortic Dissection: Observations From Irad, Elizabeth Jackson, Andreina Carbone, Sherene Shalhub, Chih-Wen Pai, Marek Ehrlich, Toru Suzuki, G Chad Hughes, Anil Bhan, Rumi Faizer, Antonio Cittadini, Alan Braverman, Eric Isselbacher, Kim Eagle, Christoph Nienaber, Eduardo Bossone

2020-Current year OA Pubs

BACKGROUND: Available data about sex differences in patients with acute aortic dissection (AAD) are scant and conflicting. The aim of this study is to assess sex-related differences in clinical characteristics, presentation, diagnostic findings, management, and outcomes among patients with type A (TA-AAD) and type B AAD (TB-AAD).

METHODS: Data about 11 586 patients enrolled in the IRAD (International Registry of Acute Aortic Dissection) from 1996 to 2022, were analyzed; 7819 (67.5%) experienced TA-AAD and 3867 (33.0%) TB-AAD. Men and women were compared with regard to diagnosis, treatment, and in-hospital and long-term survival.

RESULTS: One third of patients were women (TA-AAD, …

Impediments To Transforming The Healthcare Delivery System: Shifting The Paradigm From Provider Centric To Patient Centric, Elizabeth A. Regan, Manasa Devi Chinta

Faculty Publications

Introduction: 

Stated aims for digital healthcare transformation frequently cite goals for better coordinated patient-centric systems. However, despite advances in medical science, digital technologies, health policies, and billions of dollars invested over the past 25 years, most healthcare providers are far from fully realizing the demonstrated benefits of today's digital technologies for improving patient care. Sharing information across healthcare systems remains challenging. Problems with fragmentation, quality, inequities, and rising costs of care delivery persist. A recent study of 1,026 U.S. hospital systems found that only 15.8 percent achieved a digital maturity level needed to provide digitally enabled healthcare services to better …

Circulating Ketone Bodies And Incident Cardiovascular Outcomes And Mortality: Insights From The Uk Biobank, Parag Anilkumar Chevli, Saeid Mirzai, Richard Kazibwe, Jeff Kingsley, Alexis C Wood, Joseph Yeboah, Leandro Slipczuk, Anurag Mehta, Harpreet S Bhatia, Ambarish Pandey, Michael D Shapiro

Children’s Nutrition Research Center Staff Publications

Background: Ketone bodies (KB) are endogenous energy sources synthesized by the liver in response to metabolic stress. Their associations with atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), and mortality and their potential beneficial or harmful effects have yet to be determined. This study aimed to examine the association between KB and incident cardiovascular outcomes and mortality in a large general population cohort free from ASCVD and HF at baseline.

Methods: This analysis included 90 987 participants (mean age 56.4 ± 8.1 years; 54.7% women) from the UK Biobank without prevalent ASCVD or HF. KB were measured by nuclear magnetic resonance …

Pd-L1 Positivity Predicts A Unique Hyperaggressive Tumor Group Within Meng C Meningiomas, Vijay Nitturi, Shervin Hosseingholi Nouri, Collin English, Hsiang-Chih Lu, Elizabeth Ledbetter, Diego Rojas, Sean Lau, Malcolm Mcdonald, Jacob J Mandel, Abdul Basit Khan, Arif O Harmanci, Akdes S Harmanci, Tiemo Klisch, Akash J Patel

Duncan NRI Faculty and Staff Publications

Molecular profiling has identified 3 groups of meningiomas, with MenG C tumors exhibiting the vast majority of recurrences. Efforts to find effective treatments for recurrent meningiomas have remained elusive. Higher WHO-grade meningiomas have exhibited greater Programmed Death Ligand 1 (PD-L1) expression through various methods, but the prognostic value of PD-L1 expression has not been described in the context of molecular profiling. Additionally, trials investigating PD-1/PD-L1-targeted immunotherapies have produced disappointing results. Here, we find that PD-L1 positivity, while prevalent in MenG C tumors, does not predict recurrence in the benign MenG A and B tumors. PD-L1 positivity also occurs independently of …

Tubulin Transforms Tau And Α-Synuclein Condensates From Pathological To Physiological, Lathan Lucas, Phoebe S Tsoi, My Diem Quan, Kyoung-Jae Choi, Josephine C Ferreon, Allan Chris M Ferreon

Faculty, Staff and Students Publications

Proteins undergo phase separation to form membraneless condensates that spatially organize biomolecular interactions. These condensates can support cellular physiology or instigate pathological protein aggregation. Tau and α-synuclein (αSyn) are neuronal proteins that form heterotypic Tau:αSyn condensates associated with physiological and pathological processes. Tau and αSyn regulate microtubules, but also misfold and co-deposit in aggregates linked to neurodegenerative disease, highlighting the ambivalent impact of Tau:αSyn condensation in health and disease. Here, we show that Tubulin modulates Tau:αSyn condensates by promoting microtubule interactions and inhibiting homotypic and heterotypic pathological oligomers. In the absence of Tubulin, Tau-driven condensation accelerates formation of pathogenic Tau:αSyn …

Muscular Fitness Levels Of U.S. Children And Adolescents, Daniel J. Mcdonough, Yong Gao, Lynda B. Ransdell, Haichun Sun

International Journal of Physical Activity and Health

Purpose: To describe muscular fitness (MF) levels and percentile benchmarks among U.S. children and adolescents aged 6–15 years old across sociodemographic, physiological, and behavioral subgroups. Methods: Data were from the 2012 NHANES National Youth Fitness Survey (NNYFS). Four strength tests consisting of the plank, knee extension, modified pull-up, and handgrip, were analyzed by age, sex, race/ethnicity, income, BMI category, cardiorespiratory fitness (CRF), and physical activity (PA) among 1,234 participants (51% male) using SAS SURVEY procedures. Results: Mean ± SEM scores were 69.6 ± 1.8 s (plank), 56.6 ± 4.2 lb (left) and 59.2 ± 4.3 lb (right) knee extension, 5.5 …

Post-Traumatic Stress Disorder And Risk Of All-Cause And Cause-Specific Mortality: A Nationwide Population And Sibling-Controlled Cohort Study In Taiwan, Chih-Wei Hsu, Yang-Chieh Brian Chen, Liang-Jen Wang, Mu-Hong Chen, Yao-Hsu Yang, Chih-Sung Liang, Edward Chia-Cheng Lai

Children’s Nutrition Research Center Staff Publications

Aims: Post-traumatic stress disorder (PTSD) may shorten life expectancy, but evidence for Asian populations and cause-specific mortality remains limited. The aim of this study is to investigate the association between PTSD and mortality risk in an Asian population.

Methods: We used Taiwan's National Health Insurance Research Database (2000-2022) to assemble a cohort of 28,777 individuals with incident PTSD and 115,108 age- and sex-matched unexposed individuals, plus a sibling cohort of 13,305 affected patients and 22,030 unaffected siblings. Cox models estimated adjusted hazard ratios (AHRs) for all-cause, unnatural-cause (suicide and accidents) and natural-cause mortality, with progressive adjustment for sociodemographic factors, comorbidity …

Victimization, Health, And Help Seeking In North Dakota: How Interpersonal Violence Shapes Physical And Mental Health, Tahmid Hassan Jeeshan

Graduate Research Achievement Day Posters

Interpersonal violence extends beyond physical assault to include psychological and/or emotional abuse that can produce substantial physical and mental health consequences. This study examines how multiple forms of interpersonal violence relate to health outcomes among North Dakotan women, focusing on differences between rural and non rural residents. We compare victimization patterns, physical and mental health status, and treatment seeking behaviors. We anticipate that rural victims will report more severe or chronic victimization yet face reduced access to and use of healthcare and victim services. By jointly considering violence type, rural versus non-rural status, health outcomes, and treatment seeking, this project …

Association Between Functional Status And Cardiac Function In Chronic Heart Failure: Insights From The C-Mic Ii Trial., Marat Fudim, Tamara Kovacevic-Preradovic, Marija Zdravkovic, Sasko Jovev, Nermir Granov, Tanja Popov, Igor Rudez, Petar Vukovic, Velibor Ristic, Annette Holtdirk, Muhammad Shahzeb Khan, Faouzi Kallel, Miodrag Peric, Javed Butler, Stefan D. Anker, Dragana Kosevic, J. Eduardo Rame

Department of Medicine Faculty Papers

INTRODUCTION: Relationship between changes in cardiac function, functional capacity, and patient-reported health status in heart failure (HF) remains incompletely defined, which may help inform endpoint selection and clarify how distinct clinical domains reflect treatment response.

METHODS: This post hoc analysis of the randomized cardiac microcurrent (C-MIC) II trial, which evaluated the efficacy and safety of C-MIC therapy in patients with chronic HF with reduced ejection fraction on optimal guideline-directed medical therapy, included 65 ambulatory patients with non-ischaemic dilated cardiomyopathy, New York Heart Association (NYHA) Class III-IV symptoms, and baseline left ventricular ejection fraction (LVEF) 25-35%. Correlations between changes in Kansas …

Single-Layer Spherical (Sls) Vs Single-Layer (Sl) Woven Endobridge (Web) Device In The Treatment Of Narrow-Neck Intracranial Aneurysms: A Propensity Score-Matched Analysis, Hamza Adel Salim, Vivek Yedavalli, Fathi Milhem, Nimer Adeeb, Basel Musmar, Muhammed Amir Essibayi, Motaz Daraghma, Mahmoud Dibas, Nicole M. Cancelliere, Jose Danilo Bengzon Diestro, Oktay Algin, Sherief Ghozy, Sovann V. Lay, Adrien Guenego, Leonardo Renieri, Joseph Carnevale, Guillaume Saliou, Panagiotis Mastorakos, Kareem El Naamani, Eimad Shotar, Markus Möhlenbruch, Michael Kral, Charlotte Chung, Mohamed M. Salem, Ivan Lylyk, Paul M. Foreman, Hamza Shaikh, Vedran Župančić, Muhammad U. Hafeez, Joshua Catapano, Muhammad Waqas, Muhammet Arslan, Onur Ergun, James D. Rabinov, Julian Maingard, Clemens M. Schirmer, Mariangela Piano, Anna L. Kühn, Caterina Michelozzi, Robert M. Starke, Ameer Hassan, Mark Ogilvie, Anh Nguyen, Jesse Jones, Waleed Brinjikji, Marie T. Nawka, Marios Psychogios, Christian Ulfert, Bryan Pukenas, Jan-Karl Burkhardt, Thien Huynh, Juan Carlos Martinez-Gutierrez, Sunil A. Sheth, Diana Slawski, Rabih Tawk, Benjamin Pulli, Boris Lubicz, Pietro Panni, Ajit S. Puri, Guglielmo Pero, Eytan Raz, Christoph J. Griessenauer, Hamed Asadi, Adnan Siddiqui, Elad I. Levy, Neil Haranhalli, David Altschul, Andrew F. Ducruet, Felipe C. Albuquerque, Robert W. Regenhardt, Christopher J. Stapleton, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Boddu, Jared Knopman, Stavropoula I. Tjoumakaris, Hugo H. Cuellar-Saenz, Pascal M. Jabbour, Frédéric Clarençon, Nicola Limbucci, Vitor Mendes Pereira, Aman B. Patel, Max Wintermark, Adam A. Dmytriw

Department of Neurosurgery Faculty Papers

Data on the use of Woven EndoBridge (WEB) devices in the treatment of narrow-neck intracranial aneurysms (NNA) are limited. We compared the efficacy and safety of single-layer (SL) and single-layer spherical (SLS) WEB devices in treating NNA. We conducted a multicenter retrospective analysis of adult patients with NNA (neck ≤ 4 mm and width-to-neck ratio ≥ 2) treated with SL or SLS WEB devices between January 2011 and December 2022. Patients with fusiform or blister aneurysms, adjunctive treatments, or devices other than SL or SLS were excluded. Propensity score matching was used to adjust for confounding variables. Outcomes included procedural …

Vlx-1005, But Not Argatroban, Prevents Itam-Mediated Platelet Activation And Heparin-Induced Thrombocytopenia, Adriana Yamaguchi, Victoria Putzbach, Reheman Adili, Sophia Lazar, Livia Stanger, Devin Gilmore, David J. Maloney, Steven E. Mckenzie, James V. Michael, Michael Holinstat

Cardeza Foundation for Hematologic Research

Heparin-induced thrombocytopenia (HIT) is an immune prothrombotic disorder characterized by the binding of platelet-activating immunoglobulin G antibodies to platelet factor 4/heparin. In platelets, this leads to cross-linking of the immunoreceptor tyrosine-based activation motif (ITAM)-bearing receptor FcγRIIa, platelet activation, and thrombocytopenia, which in combination with extensive thrombin generation significantly increases the risk of thrombosis. Our laboratory has previously demonstrated that 12-lipoxygenase (12-LOX), an oxygenase primarily expressed in platelets, plays a critical role in platelet activation through FcγRIIa. In this study, we aimed to determine the effectiveness of VLX-1005, a potent and selective inhibitor of 12-LOX, alone or in combination with argatroban, …

Single Ventricle Physiology May Not Preclude Cardiac Repair In The Setting Of Congenital Diaphragmatic Hernia, Kylie I Holden, Michael C Scott, Ashley H Ebanks, Amir M Khan, D Michael Mcmullan, Anthony Johnson, Charles S Cox, Matthew T Harting, Damien J Lapar

The Brown Foundation: Institute of Molecular Medicine

Objective: Management for congenital heart disease (CHD) with congenital diaphragmatic hernia (CDH), particularly in single ventricle physiology, is challenging, with limited studies showing poor outcomes. This investigation evaluated outcomes for these complex patients.

Methods: This retrospective cohort study (2007-2022) from the CDH Study Group analyzed mortality in patients with CDH and single ventricle physiology, using standard statistical methods and Cox regression for estimation.

Results: A total of 9,261 CDH patients were identified, including 1,886 with CDH + CHD and 131 with single ventricle physiology. The median gestational age was 38 weeks and birthweight was 2.8 kg. Of 131 patients, 34 …