Medicine and Health Sciences Commons^™

Detection Of Serotype Gene Of Klebsiella Pneumoniae Isolated From Different Clinical Cases Of Hospitalized Infections In Al-Diwaniya City, Adnan H. Al Hamadani, Hazem K. Al Khafaji, Ahmed S.Abed

Al-Qadisiyah Medical Journal

This study aimed to identify serotype of Klebsiella Pneumonia  isolated from different clinical cases of hospitalized infections( urinary tract infection, respiratory infection, burns & wounds) by using polymerase chain reaction(PCR).A total of 110 clinical specimens from in-patients with nosocomial infections(including 47 respiratory infection,37  UTI , burns  & wound infections 26) in Al-Diwaniya Teaching Hospital during the period from December 2012 –March 2013 were collected. K. Pneumonia  isolated from 35.4% of the specimens distributed as 18.18% sputum specimens,10.90% urine specimens & 6.36% burns & wounds specimens. K1,K2,K5,K20,K54 & K57 serotypes of K. Pneumonia  were successfully detected in multiplex PCR.The results revealed …

Overexpression Of Mammaglobin In Tissue Breast Carcinoma By Immunohistochemistry, Shoroq Mohammad Abbas

Al-Qadisiyah Medical Journal

Our purpose was to investigate the mammaglobin overexpression in tissue breast cancer and to determine its correlations with conventional prognostic parameters. There were investigated 60 patients with breast carcinoma, and slides from paraffin blocks were stained with an antibody against mammaglobin. The immunohistochemical reaction was scored based on the percentage of positive tumor cells in tumors. Positive reaction for mammaglobin was diffused cytoplasmic staining foundin 75% of tissue breast carcinoma. A significant correlation was found between the mammaglobin expression in the breast cancer and grades of the tumor. Out results suggest that mammaglobin is a good prognostic marker forbreast carcinomaAim …

Histopathological Study On The Effect Of Antioxidants (Vitamin E And Selenium) In Hepatotoxicity Induced By Lead Acetate In Rats, Adnan W. Al-Bideri

Al-Qadisiyah Medical Journal

The study was carried out to evaluate histopathological changes inrats liver induced by different doses and durations of lead acetate toxicity and to investigate the therapeutic effects of vitamin E and Selenium together against lead poisoning.Thirty two adult male rats (Rattus rattus), randomized into four groups (n=8) were used for this study. In group I rats received only drinking water as control while in   group II , III and IV rats were given o.5%,1%,1.5% lead acetate respectively in drinking water for ten weeks. Two animals from each group were sacrificed and and dissected after five weeks and ten weeks of …

The Degree Of Bother Of Nocturea On Quality Of Life In A Group From Al-Diwaniya Population, Ali Hamdan Alkinany, Muntather Hameed Neema, Falah Mehdy Ali, Ahmed Abdulameer Alwan

Al-Qadisiyah Medical Journal

Background: Nocturia is common and disrupts sleep. Traditionally, one nightly episode has been regarded as clinically meaningless.Objective: To evaluate the bothersome effect of nocturia on health related quality of life (HRQoL) in a group from Al-Diwaniya population.Patients and methods: In 2006–2008, a survey was made on a random sample of 600 patients aged 18–79 yr who were identifiedfrom Al-Diwaniya teaching hospital, proportion was 62% males and 38% were females).Measurements: bother from nocturia on QoL were examined in relation to self-reported nocturia frequency (using the American Urological Association Symptom Score). Bother from nocturia was assessed on a four-point scale (none, small, …

Challenges Of Electronic Medical Record Implementation From The Perspective Of Hospital Leaders In Riyadh, Kingdom Of Saudi Arabia's Public Hospitals: A Mixed-Methods Study, Atheer A. Alghamdi, Samiha H. Sayed

Saudi Medical Journal

Objectives: To assesses the challenges of implementing electronic medical records (EMR) from the leaders' perspective in public hospitals in Riyadh, Kingdom of Saudi Arabia (KSA), and explores their suggestions for improvement. Methods: A concurrent mixed research approach using a purposive sample of all hospital leaders (61) involved in EMR in 5 randomly selected public hospitals utilizing EMR in Riyadh. The researchers deployed a semi-structured interview schedule to collect the data. They used descriptive statistics and ordinal regression analysis for quantitative data, and thematic analysis for qualitative data. Results: Indicate that 80.3% of the hospital leaders had a good perception of …

The Use And Utility Of Wearable Devices For Tracking Sleep And Activity In Inpatient Mental Health Settings: Protocol For A Rapid Review, Gillian Strudwick, Hwayeon Danielle Shin, Iman Kassam, Karishini Ramamoorthi, Benjamin Rosen, Michelle A Patriquin, Justin Baker, Nicholas Neufeld

Faculty, Staff and Student Publications

Background: Wearable devices offer an opportunity to objectively monitor and capture sleep and activity in psychiatric inpatient settings, where traditional approaches often rely on subjective reporting or staff observation, both of which have inherent flaws. Technologies such as Fitbit, Garmin, Oura Ring, GENEActiv, Empatica, and WHOOP (among others) have been used to passively collect physiological data that may inform care planning and clinical decision-making. Despite growing interest, the extent to which these wearables are feasible, acceptable, and useful in inpatient mental health settings remains unclear. Synthesizing this evidence is essential to inform their potential integration into psychiatric care.

Objective: This …

Experiences Of Lgbtqia+ Medical Students: Gaps And Challenges During Preclinical Education., Samantha Temucin, Natalie Florescu, Paige Varin, Leeann Tanaka, Robert Bettiker, Erin N Harrop, Kendrin Sonneville

PCOM Scholarly Works

Background

While attempts to diversify the physician workforce are ongoing, limited research exists exploring the experiences LGBTQIA+ medical students during their preclinical training. The purpose of this study is to examine how interpersonal interactions, campus climate, and the availability of campus support influence the well-being of LGBTQIA+ medical students across U.S. medical schools during their preclinical education.

Method

Medical students self-identifying as LGBTQIA + and enrolled in either Doctor of Medicine (MD) or Doctor of Osteopathic Medicine (DO) institutions in the U.S. in 2024 completed an online, 136-item survey. Participants were asked about preclinical medical school experiences, perceptions of their …

The Schizophrenia Effect: Families Facing Schizophrenia-Spectrum Disorders, Ginger A. Christmas

Doctoral Dissertations and Projects

Schizophrenia is primarily known for its bizarre psychosis, as the brain struggles to distinguish between what is real and what is not. This qualitative study employed constructive, interpretative phenomenological analysis (IPA) to explore the idea that families with a family member diagnosed with a schizophrenia-spectrum disorder (SSD) in the United States have specific needs, which may include social and spiritual support and integration into treatment. While the needs of families facing SSD have been studied in non-Western countries, the schizophrenia effect on families in the U.S. remains less understood. A purposive sample of 11 individuals, representing 15 family members with …

Molecular Risk Markers Define Risk Of Relapse In Myeloid Leukemia Of Down Syndrome Beyond Measurable Residual Disease., Jason N. Berman, Anupam Verma, Shelton Viola, Todd A. Alonzo, Yi-Cheng Wang, Lisa Eidenschink Brodersen, Michael Loken, Amy Beckman, Betsy Hirsch, Susana Raimondi, Karen M. Chisholm, Xiaotu Ma, Rhonda Ries, Soheil Meshinchi, Alan S. Gamis, Reuven Schore, Jeffrey W. Taub, E Anders Kolb, Todd Cooper, Johann Hitzler

Manuscripts, Articles, Book Chapters and Other Papers

Myeloid leukemia of Down syndrome (ML-DS) is a distinct form of pediatric acute myeloid leukemia (AML) that responds to reduced-intensity chemotherapy, as compared with non-DS AML that requires intensive chemotherapy and often stem cell transplant. While most patients with ML-DS have a favorable prognosis, outcomes for those with refractory or relapsed disease are dismal. Children's Oncology Group study AAML1531 introduced the use of measurable residual disease by multiparameter flow cytometry at the end of the first course of induction therapy (EOI-1 MRD) for risk stratification of treatment intensity. Of 280 patients with ML-DS who were enrolled, 41 were classified as …

Differential Contributions Of Clpx And Clpp To Pulmonary Virulence In Classical And Hypervirulent Klebsiella Pneumoniae, Nathan M Lin, Emily C Marino, Jordan M Schlotmann, David A Rosen

2020-Current year OA Pubs

No abstract provided.

Hematopoietic Cell Transplantation For Wiskott-Aldrich Syndrome: A Pidtc Report, Jessie L Alexander, Jeffrey J Bednarski, Et Al.

2020-Current year OA Pubs

Wiskott-Aldrich syndrome (WAS), an X-linked disorder characterized by immunodeficiency, thrombocytopenia, autoimmunity, and malignancy, can be effectively treated with allogeneic hematopoietic cell transplantation (HCT). Older age at HCT and mismatched donors are known to affect overall survival (OS). However, the influence of specific clinical manifestations or WAS variant class on OS and factors associated with event-free survival (EFS) remain incompletely defined. We analyzed outcomes of 308 patients with WAS who underwent HCT at 37 institutions of the Primary Immune Deficiency Treatment Consortium from 1990 to 2018. With a median follow-up of 5.3 years, the 5-year OS and EFS were 87.2% and …

Adaptations To An Implementation Study For Integrating Hypertension Management Into Hiv Care In Lagos, Nigeria: Application Of The Frame, Chioma Hope Nwankwo, Juliet Iwelunmor, Et Al.

2020-Current year OA Pubs

BACKGROUND: Implementation strategies are dynamic and multi-faceted, and may require adaptations to fit implementation contexts, especially in lower-and-middle income countries. We report the adaptations for an ongoing late-stage implementation science trial (R01HL147811) that integrates hypertension management into HIV care in Lagos, Nigeria - a country with a high dual-disease burden - through the Task Strengthening Strategy for Hypertension (TASSH) intervention and Practice Facilitation implementation strategy.

METHODS: FRAME (Framework for Reporting Adaptations and Modifications-Enhanced) modules were used to record adaptations to the intervention (i.e., TASSH) respectively, enhance participant recruitment and retention rates, and increase frequency of trainings. Data collection sources included …

Ultrasound-Guided Skeletal Muscle Biopsy Technique Permits Measurement Of Structural, Functional, Cellular And Biochemical Properties, Addison Barber, Amber Willbanks, Guadalupe Meza, Jeremie L A Ferey, Gretchen A Meyer, Sudarshan Dayanidhi, W David Arnold, Richard L Lieber, Ishan Roy

2020-Current year OA Pubs

Human muscle biopsies are often required to study or diagnose diseases. However, traditional approaches are challenging due to limited sample size, quality, or participant discomfort. Fine-gauge needle biopsies (≥ 14-gauge), present an alternative but may yield insufficient tissue for comprehensive analysis. Ultrasound guidance, coupled with vacuum-assisted, single needle-insertion multiple sampling addresses these challenges. In 19 healthy participants (mean age: 30.1 ± 10 years, 42% male), 2-3 samples were collected from a single needle insertion into the vastus lateralis (VL) and tibialis anterior (TA). Summed VL and TA sample masses averaged 148 ± 38 mg and 166 ± 64 mg, with …

Recommendations For The Diagnosis And Management Of Cln3 Disease (Batten Disease) Using The Delphi Consensus Methodology, Jonathan W Mink, Jonathan D Cooper, Et Al.

2020-Current year OA Pubs

BACKGROUND: CLN3 disease, also called Juvenile Neuronal Ceroid Lipofuscinosis (JNCL), or Batten disease, is an ultra‑rare, neurodegenerative lysosomal storage disorder generally affecting individuals during the first decade of life. There can be a delay in diagnosis or misdiagnosis due to a lack of awareness, and when the most common presenting symptom of visual loss is attributed to more common conditions affecting vision. METHODS: We used a previously published Expert Mapping Tool (EMT) to identify multidisciplinary professionals with diagnostic or clinical management expertise, as well as patient advocates with experience of CLN3 disease. A systematic literature review of published evidence using …

A Practice-Based Implementation Strategy Bundle For Integrating Behavioral Health In Primary Care: A Matrixed Multiple Case Study, Gretchen Buchanan, Kelley Mccall, Lorella Palazzo, Michelle Bagwell, Shivani Patel, Shravya Allena, Byron J Powell

2020-Current year OA Pubs

BACKGROUND: Integrated behavioral health (IBH) is an evidence-based approach to addressing mental health in primary care settings. It typically involves augmenting a primary care team with a behavioral health professional (e.g., psychologist, licensed clinical social worker) who sees patients for brief, focused concerns; can function as a bridge to specialty care; and provides medical providers with support and education about patient behavioral health concerns. IBH has slowly begun to disseminate across the United States, but practices encounter significant implementation barriers. How IBH is implemented has not been systematically studied outside of trials, yet this study could provide a rich foundation …

Paternal Alienation, Paternal Strain, Generativity, Adjustment, And Resilience (P-Apgar): A Conceptual Framework For Fathers’ Perinatal Psychosocial Adjustment, Rachael Elizabeth Schmitz

Nursing and Health Sciences

Paternal perinatal depression is underrecognized, and existing tools often fail to capture male-specific symptomatic expressions. Fathers experience significant psychosocial changes during the transitional period, yet clinical assessment of paternal mental health remains largely absent from routine clinical practice. This paper introduces a multi-dimensional tool called the P-APGAR. The theory-informed conceptual tool is meant to guide the assessment of fathers’ perinatal adjustment, operationalizing core elements of role-based, relational, and emotional adaptation. The model adapts the logic of the traditional newborn APGAR score to a father-centered context based on Paternal Identity, Alienation, Paternal Strain, Generativity, Adjustment, and Resilience. A theoretical synthesis approach …

Psychological And Behavioral Determinants Of Vaccine Efficacy: Insights From Sars-Cov-2 And Implications For Future Pandemics, Amir Sasan Mozaffari Nejad, Ariyo Shahin Jafari, Ahmed S. Abdel-Moneim, Hakimeh Karami, Behrooz Ataei, Sara Mohammed Ali

All Works

No abstract provided.

Virtual Reality For The Management Of Postoperative Pain And Anxiety In Children And Adolescents Undergoing Nuss Repair Of Pectus Excavatum: Randomized Controlled Trial, Charlotte M. Walter, Dillon Froass, Nora Bell, Lauren Haack, Chloe Boehmer, Claudia Bruguera Torres, Rachel Spivak, Max Chou, Kristie Geisler, Keith O'Conor, Sara E. Williams, Lili Ding, Christopher D. King, Vanessa A. Olbrecht

Department of Medicine Faculty Papers

BACKGROUND: Virtual reality (VR) is a novel technology with implications for pain and sensory processing. VR may serve as a novel, scalable method to deliver clinically validated therapy for pain management as an alternative or adjunct to opioids for acute pain. Given that psychological factors and pain perception are both components of postoperative pain, it may also be beneficial to incorporate modalities that decrease anxiety, such as active relaxation and guided meditation with VR. Unfortunately, these therapies are not widely available due to multiple barriers. VR has the potential to deliver pain-reducing, psychologically based therapy to children, thereby enhancing multimodal …

Health Disparities Resulted From The Relationships Between Vulnerable Patients And Providers, Matthew Maurice Bradley

Doctoral Dissertations and Projects

The study's purpose was to understand patterns of mistrust between providers and patients in vulnerable and underserved populations. The theories guiding this study were the critical theory and the critical race theory created by Max Horkheimer as it explains how people can collaborate and actively participate in rebuilding trust. The intention is to rebuild trust and reduce health disparities in the United States. The general problem is the lack of provisional resources for underserved and vulnerable communities, resulting in the population lacking trust in healthcare administration. Speicher and Francis (2022) examined how increasing physician turnover, burnout, depression, and dissatisfaction affect …

A Multi-State Look Into Early Intervention Speech-Language Pathologists’ Confidence Identifying And Diagnosing Autism, Allison Gladfelter, Adelaide Parr, Anna Cannone, Sarah O'Connor

CISLL Publications

Purpose: Although autism can be reliably diagnosed by 18 months of age, long wait times and limited access to qualified providers prevent families from obtaining timely diagnostic services. Trained speech-language pathologists (SLPs) are qualified to diagnose autism, ideally as part of a multidisciplinary team. SLPs working on early intervention (EI) teams are well-situated to help close this diagnostic wait time gap. The purpose of this survey study was to explore EI SLPs’ experiences serving autistic children, confidence in identifying and diagnosing autism, and their perceptions of barriers or facilitators to diagnostic confidence and wait times.

Method: 287 EI SLPs from …

Investigating Nursing Instructors’ Perceptions Of Students’ Critical Thinking And Clinical Judgment After Attending A Flipped Pathophysiology Course, Ashley L. Harmon

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to understand an instructor’s ability to develop critical thinking and clinical judgment for pathophysiology nursing students at a state university in the southeastern United States while using the flipped pedagogical approach. The theory guiding this study was Piaget’s constructivist theory, which aligned with the active role of learners in constructing knowledge, and supported the exploration of how flipped classrooms influenced the development of critical thinking and clinical judgment. The central research question for this study was: What are nursing instructors’ perceptions of students' development of critical thinking and clinical judgment when applying pathophysiology …

Comparative Evaluation Of Orthodontic Measurements Using Two Intraoral Scanners Versus Conventional Plaster Models: An In Vivo Study, Pranoy Nair, Achint Juneja, Monis Raza, Prashant Shahi, Ridhi Kothari, Deepthi Raj

International Arab Journal of Dentistry

Introduction: This study evaluated and compared the accuracy and reliability of two intraoral scanners, iTero Element 1 and Panda P2, with conventional plaster models for essential orthodontic measurements.

Methods: Thirty subjects were evaluated using three methods: plaster casts, iTero Element 1, and Panda P2. Inter-canine distance, inter-molar distance, overjet, overbite, and Bolton’s ratios were measured. Data was analysed using one-way ANOVA and Tukey’s post-hoc test after confirming normality (Shapiro–Wilk). Intra-operator reliability was assessed using Dahlberg’s formula and ICC.

Results: No statistically significant differences were observed among the three methods (p > 0.05). Both scanners demonstrated high repeatability and minimal measurement error, …

Bacterial Fecal Microbiome Composition Associated With Hiv Stage Among Rural And Peri-Urban Adults Living With Hiv In Uganda, Bożena M Morawski, Elise R Morton, Miya Yunus, Claudia Muñoz-Zanzi, Rojelio Mejia, Ran Blekhman, David R Boulware, Sarah M Lofgren

Faculty, Staff and Students Publications

Background

Gut microbiome composition in HIV-infection provides insight into HIV pathogenesis and potentially offers avenues to adjunctive HIV therapies. Although two-thirds of people living with HIV (PLHIV) are in Africa, studies of the gut microbiome PLHIV have focused on non-African populations. Additionally, social, cultural, and environmental factors influence the gut microbiome and differ substantially between African and Western and urban and rural communities. Here, we quantify the relationships between immune status and fecal microbiome composition in 175 rural Ugandan PLHIV.

Methods

In 2013, 175 Ugandan PLHIV contributed a single fecal sample as part of a cohort study of 202 participants. …

The Association Of P27 With Prostate Cancer Outcomes: A Secondary Analysis Of Nrg/Rtog 8610 And 9202, Krishnan Patel, Stephanie Pugh, Jeffry Simko, Anthony Zietman, Michelangelo Fiorentino, David Paul D'Souza, Seth Rosenthal, Adam Currey, Adam Dicker, Bradley Stish, Eric Horwitz, Tyler Robin, Michael Dominello, Christopher Peters, Kwang Choi, Jason Efstathiou, Samir Narayan, George Daniel Grass, Zaker Rana, Phuoc Tran, Massimo Loda, Paul Nguyen

Kimmel Cancer Center Faculty Papers

PURPOSE: The cyclin-dependent kinase inhibitor p27 is a well-profiled modulator of cell cycle progression. Low nuclear p27 levels have been demonstrated to have a negative prognostic impact on outcomes in patients undergoing prostatectomy. The prognostic value of p27 after radiation therapy (RT) for prostate cancer is unknown.

METHODS AND MATERIALS: Levels of p27 were evaluated in pre-RT prostate biopsy samples from 2 randomized, phase 3 trials, NRG/RTOG 8610 and 9202, which treated patients with RT with or without androgen deprivation therapy (ADT). Nuclear p27 was analyzed using immunohistochemistry and quantified using automated imaging analysis. The association of p27 as both …

Incidence And Risk Factors Of Recoarctation Following Surgical Repair Of Aortic Coarctation In Infants: A Retrospective Single-Centre Study, Hamid Atiyaq Al Badi, Hamood Al Kindi, Khalid Al Alawi, Abdullah Al Furqani, Laith Al Kindi, Madan Mohan Maddali

Sultan Qaboos University Medical Journal

Objectives: The reported incidence and risk factors for aortic recoarctation (reCoA) after surgical repair in infants vary widely. This study aimed to determine the incidence of reCoA and to identify associated risk factors in a cohort of infants. Secondary objectives included assessing parameters associated with reintervention. Methods: This retrospective cohort study was conducted at the National Heart Center, Muscat, Oman, and included all infants who underwent surgical repair of coarctation of the aorta (CoA) from January 2016 to December 2022. Preoperative, intraoperative and postoperative data were collected, including demographics, prostaglandin E2 use, surgical technique and echocardiographic measurements. Recoarctation was defined …

International Consensus-Driven Recommendations For Patient-Reported Outcome Research Objectives In Early Phase Dose-Finding Oncology Trials: Optimise-Ror, Emily Alger, Olalekan Lee Aiyegbusi, Amylou C Dueck, Anna Minchom, Madeline Pe, John D Peipert, Claire Snyder, Stefan N Symeonides, Roger Wilson, Ethan Basch, Yu Qiao, Susan E Bates, Helen Bulbeck, Lizzie Dean, Massimo Di Maio, Aaron R Hansen, Olga Kholmanskikh, Ken Kobayashi, Dónal Landers, Christophe Le Tourneau, J Jack Lee, Brigette B Y Ma, Lynley V Marshall, Sheetal Patel, Joan Petrie, Gregory R Pond, Kieran Prior, Khadija R Rantell, John F Reeve, Olga Solovyeva, Nolan A Wages, Harald A Weber, Melanie J Calvert, Christina Yap

Faculty, Staff and Student Publications

Purpose: There is growing scientific interest in incorporating patient-reported outcomes (PROs) in early phase dose-finding oncology trials (DFOTs) to assess tolerability, inform dose selection, and guide later stage trial design. However, research indicates that PRO objectives in DFOTs are often unclear. The Incorporating Patient-Reported Outcomes in Dose-Finding Trials-Research Objectives Recommendations (OPTIMISE-ROR) project was established to support trialists to effectively incorporate PROs into DFOTs.

Methods: Using the Enhancing Quality and Transparency of Health Research (EQUATOR) Network's methodological framework, guideline development included the following: (1) a methodological review of published DFOTs incorporating PROs; (2) candidate item generation, refined through expert consultation; (3) …

Clinical Trial Success Rate In Lymphoma: Fate Of Trials And Agents From 2000 To 2019, Zhiping Luo, Meng Li, Brian C Primeaux, Rahul Shah, Ruitao Lin, Swaminathan P Iyer, Loretta J Nastoupil, Michael R Green, Jason R Westin, Christopher R Flowers, Dai Chihara

Faculty, Staff and Student Publications

Although previous studies have examined the drug development and clinical trial success rates in oncology, a comprehensive analysis of development success rate in lymphoma has not been performed. Therefore, we analyzed lymphoma trials initiated between 1 January 2000 and 31 December 2019, using the Trialtrove database and ClinicalTrials.gov. We identified phase 1, 2, and 3 trials that included patients with lymphoma and analyzed the transition rate of investigational agents across phases and their US Food and Drug Administration (FDA) approval rates to assess the efficiency and success of the clinical development process. A total of 1032 phase 1 trials and …

The Role Of Personality In Collegiate Athletes’ Indicators Of Performance And Injury Experiences – A Mixed Methods Study, Allison Traub

Doctoral Dissertations and Projects

This mixed methods study explores the impact of collegiate athletes' indicators of personality traits as attributed to athletic performance, injury experiences, and sport identity. Sports often emphasize physical abilities, yet the role of personality is equally significant—though it has received comparatively little attention in psychological research. This research addresses such a gap through examining how personality traits shape athletes’ competitive behavior along with coping strategies. The traits are defined within the 16 Personalities framework using Myers-Briggs Type Indicator (MBTI) and how it influences just how athletes recover. This research will explore research questions such as how personality affects college athletes' …

Potency-Related Effects Of Smoked Cannabis On Simulated Driving Performance: A Randomized, Controlled Crossover Trial, Bruna Brands, Adam Zaweel, Madison Wright, Patricia Di Ciano, Christine M. Wickens, Justin Matheson, Andrew Fares, Omer S. M. Hasan, Marcos Sanches, Beth Sproule, Marilyn A. Huestis, Timothy L. Brown, Bernard Le Foll

Institute of Emerging Health Professions Faculty Papers

Given the increasing availability of high-potency Δ9-tetrahydrocannabinol (Δ9-THC) products, understanding potency-related effects of Δ9-THC on driving performance is an important public safety issue. This randomized, double-blind, placebo-controlled, within-subjects trial examined the effects of smoked cannabis with varying Δ9-THC concentrations on simulated driving. Adults aged 19–45 who regularly used cannabis and held valid driver’s licenses completed simulated driving tasks after smoking placebo, or cannabis containing low (6.25%/47 mg Δ9-THC), medium (12.5%/94 mg Δ9-THC), or high (22%/165 mg Δ9-THC) Δ9-THC levels. The primary outcome was mean speed (km/h); secondary measures included maximum speed, standard deviation of lateral position (SDLP), reaction time (RT), …

Endometriosis Knowledge Among Emergency Medicine Providers: Diagnostic Skills And Symptom Recognition, Caidon Iwuagwu, Laurel X. Chen, Ellen Slattery, Pranjal Srivastava, Hamsitha Karra, Sheyenne Tung, Adrienne Burton, Camila Bomtempo, Jamie Aranda

Department of Surgery Faculty Papers

Objective: Endometriosis is associated with significant diagnostic delays, averaging 6.7 years, largely due to nonspecific symptoms and inadequate diagnostic approaches. Over 15,000 emergency department (ED) visits in the United States annually involve patients with endometriosis, highlighting the need for knowledge of endometriosis. This study surveys emergency medicine (EM) attendings, residents, nurse practitioners, physician assistants, and fellows to assess knowledge and practice in managing endometriosis-related ED complaints. Methods: A questionnaire from a prior endometriosis survey was modified for EM providers and administered anonymously via email (Qualtrics, Provo, UT) in monthly newsletters to providers at an academic and six associated community EDs. …