Medicine and Health Sciences Commons^™

Goal-Directed Perfusion Strategies And Postoperative Acute Kidney Injury: A Scoping Review, Austin Davis

Student Works

Background: Acute kidney injury (AKI) remains a frequent and clinically important complication following cardiopulmonary bypass (CPB). Goal-directed perfusion (GDP) strategies—most commonly targeting indexed oxygen delivery (DO₂i) and/or other hemodynamic and metabolic parameters—have been proposed to reduce renal injury by improving renal oxygenation and perfusion during CPB.

Methods: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses – Scoping Review (PRISMA-ScR) compliant scoping review identified 28 adult CPB studies evaluating GDP strategies and postoperative AKI outcomes.

Results: Maintenance of indexed oxygen delivery (DO2i) above critical thresholds and minimizing hemodilution were consistently associated with reduced AKI.

Conclusion: GDP strategies centered on maintaining …

Lived Experiences Of Shingles Vaccine-Hesitant Adults Over Age 50 In Riverside County, California, Michelle Beatrice Loomis

Walden Dissertations and Doctoral Studies

Shingles (herpes zoster) causes substantial morbidity, especially among adults over age 50 in the United States. There is a need to better understand the reasons behind low vaccination rates among adults over age 50 given the associated risks for infection and adverse health outcomes that can reduce their quality of life. This qualitative interpretative phenomenological study explored how individuals’ perceptions of the benefits, barriers, susceptibility, and severity of shingles influence vaccine intentions and identified what factors influence vaccine uptake. The health belief model was used to guide the study. Data were collected from one-on-one semistructured virtual interviews with eight adults …

Evaluating The Relationship Between Vitamin D Supplementation, Lifestyle, Social Determinants Of Health, Asthma, And Respiratory Tract Infections, Yun O'Donnell

Walden Dissertations and Doctoral Studies

Hypovitaminosis D is a significant public health concern in the United States associated with inadequate sunlight exposure and insufficient dietary intake. Asthma is a chronic respiratory condition that progressively worsens over time. While asthma is typically managed through individual-level treatment approaches, population-level strategies such as vitamin D supplementation and food fortification policies have not been implemented. A five-tier Public Health Impact Pyramid theoretical foundation guided this nonexperimental quantitative cross-sectional study. Data from 2013-2014 and 2017-2018 NHANES (n = 1,456) was evaluated for relationships between vitamin D supplementation, duration of sunlight exposure, and food security index, with asthma, asthma exacerbation severity, …

The History Of Women In Neuroradiology In North America From 1990 To The Present, Vijay M. Rao

Department of Radiology Faculty Papers

From 1990 to 2024, women neuroradiologists in North America have made tremendous progress in the areas of leadership, clinical innovation, research, education, diversity, equity and inclusion, and global outreach. This chapter begins with summaries of their key accomplishments in four broad domains, followed by short biographical sketches of numerous luminaries organized by leadership roles and areas of expertise, and ending with conclusions and future directions.

Mental Health Under Pressure: A Scoping Review Of Suicide In The Dental Workforce, Man Hung, Spencer John, Nicholas Beasley, Amir Mohajeri, Connor Schwartz, Martin S. Lipsky

Institute on Aging Publications

Aims:

Suicide among healthcare professionals is a growing concern. Despite evidence of high psychological distress in dental practice, suicide in dentists remains underexplored. This scoping review systematically examined the literature on suicide and suicidal ideation among dentists, including prevalence, risk factors, and temporal trends.

Methods:

Searches of PubMed, Scopus, Web of Science, and Dentistry and Oral Sciences Source identified English-language studies reporting suicide, suicidal ideation, or related mental-health risks in dental professionals. Duplicates were removed; titles/abstracts and full texts were screened against predefined criteria. Data were extracted and thematically analysed.Results Fourteen studies met the inclusion criteria and were mostly retrospective …

Gamified Simulation Training: An Opportunity For Improvement In Healthcare Education, Naya Hawkins-Grier, Ashley Martinez, Tara Subrahmanyan, Kelly Fan, Ryan Leudtke

Posters

Introduction: Improvements to education are currently being studied, as lectures alone have been shown to lack the ability to engage students effectively. Research has shown that simulation-based methods are promising new methods; however, they still leave room for improvement in the area of motivation. This program was introduced to introduce gamification to the WMed EIH2 program during the simulation section. The aim of this addition is to improve information retention and engagement among the kalamazoo high school student during the program. Methods: During each monthly session, the students were divided into two groups. Both groups completed individual pre-quizzes, …

Bdcd: A Comprehensive Brain Disease Cell-Cell Communication Database, Xinyi Liu, Citu Citu, Wendao Liu, Nitesh Enduru, Andi Liu, Chia-Hao Tung, Zhongming Zhao

Faculty, Staff and Student Publications

Dysregulated cell–cell communication (CCC) is increasingly recognized as a driver of brain disease pathology, contributing to neuroinflammation, synaptic dysfunction, and neurodegeneration. Nevertheless, existing resources remain limited in brain specificity, regional coverage, and functional annotation. To address this gap, we develop the Brain Disease Cell-cell communication Database (BDCD), the first comprehensive resource focused on CCC networks across major brain diseases. BDCD integrates 38 manually curated datasets, comprising 8 519 425 single cells from single-cell RNA-seq studies and 140 744 spots from spatial transcriptomic maps, spanning 14 brain regions and 13 canonical cell types covering Alzheimer’s disease, Parkinson’s disease, schizophrenia, bipolar disorder, …

Eeg In Patients With Altered Mental Status In The Emergency Department, Mariama Runcie, Neal Nolan, Olivia Yoo, Robert Silbergleit, Fábio A Nascimento, Maura Kennedy, M Brandon Westover, Joshua N Goldstein

2020-Current year OA Pubs

BACKGROUND: Altered mental status is a common chief complaint in the emergency setting, and the initial evaluation often fails to find an etiology. Subclinical (electrographic) seizures and nonconvulsive status epilepticus (NCSE) are potential causes of delirium and altered mental status, but require electroencephalogram (EEG) for diagnosis. It is not clear how often subclinical seizure or NCSE is present in those with undifferentiated altered mental status, nor which patients are most likely to benefit from emergent EEG. METHODS: We performed a retrospective review of patients presenting to a single academic medical center emergency department (ED) over a one-year period with the …

Depolymerizing F-Actin Accelerates The Exit From Pluripotency To Enhance Stem Cell-Derived Islet Differentiation, Nathaniel J Hogrebe, Mason D Schmidt, Punn Augsornworawat, Sarah E Gale, Mira Shunkarova, Jeffrey R Millman

2020-Current year OA Pubs

In this study, we demonstrate that cytoskeletal state at the onset of directed differentiation impacts the exit of human pluripotent stem cells (hPSCs) from pluripotency and downstream lineage specification. In particular, depolymerizing F-actin with latrunculin A (latA) during the first 24 h of definitive endoderm formation facilitates efficient loss of pluripotency and alters Activin/Nodal, BMP, c-Jun, and WNT signaling dynamics. These signaling changes influence downstream patterning of the gut tube, leading to improved pancreatic progenitor identity and decreased expression of markers associated with other endodermal lineages. Continued differentiation generates islets containing a higher percentage of β cells that exhibit improved …

Nanog Proximity Proteomics Maps Neighborhood Hubs Linked To Mesenchymal Stem Cell Stemness And Chromatin Control, Kyoung-Jae Choi, Michail Tyryshkin, Harathi Jonnagaddala, Allan Chris M Ferreon, Marian Kalocsay, Josephine C Ferreon

Faculty, Staff and Students Publications

NANOG overexpression has been reported to reverse aging-associated decline in mesenchymal stem/stromal cell (MSC) function, but the molecular machinery engaged by NANOG in MSCs remains incompletely defined. Here, we applied APEX proximity labeling coupled with quantitative mass spectrometry to define the NANOG proximity interactome (proxeome) in human MSCs. Of 1040 quantified proteins, 828 were significantly enriched in the APEX-NANOG (H2O2 labeling) samples, consistent with a broad NANOG-centered neighborhood rather than a single stoichiometric complex. Enriched proteins encompass RNA-processing pathways (including splicing/RNP factors and selected m6A-related proteins), transcriptional coactivation and elongation control (Mediator and 7SK/P-TEFb regulators), chromatin repression/poising modules (Polycomb and …

Geographic Variation In Adrd Prevalence And Mortality And Their Association With Social Vulnerability Across Us Counties: A Spatial Epidemiological Analysis Using Norc And Cdc Svi Data, Dean Kyne

Sociology Faculty Publications

Introduction: Geographic disparities in Alzheimer’s disease and related dementias (ADRDs) remain insufficiently understood at the national scale, limiting efforts to address inequities in dementia burden across USA communities. This study examined county-level variation in ADRD prevalence and mortality and evaluates the association between social vulnerability and these outcomes.

Methods: This cross-sectional ecological study analyzes 2020 county-level ADRD prevalence and all-cause mortality among Medicare beneficiaries from the NORC Dementia DataHub. The analytic sample included 3,108 USA counties in the contiguous USA and the District of Columbia. ADRD outcomes included (1) prevalence of highly likely ADRD and (2) prevalence of all determinations, …

Exploring The Ethical And Practical Considerations Of Artificial Intelligence In Real-World Health Care Settings: Stakeholder Focus Group Study, Carmen Wendy Ulizio, Devika Dua, Naya Meenkashi Mukul, Santosh Areti, Kristin Kostick-Quenet, Vasiliki Nataly Rahimzadeh

Center for Medical Ethics and Health Policy Staff Publications

Background: Artificial intelligence (AI) technologies continue to transform how we research human disease, diagnose and treat patients, and operate hospitals. However, emerging ethical dilemmas surrounding their design, use, and oversight demand both policy attention and empirical research.

Objective: This study aims to explore current AI development, integration, and use activities across the Texas Medical Center (TMC), the largest medical center in the world, and identify emerging ethical priorities.

Methods: We conducted a total of 3 qualitative focus groups via Zoom (Zoom Video Communications, Inc) between May and June 2025 to gauge the perspectives of 19 clinicians, developers, administrators, and patient …

The Effect Of Articulatory Cues On Phonemic Segmentation, Word Reading, Nonword Reading, And Nonword Spelling: A Clinical Trial, Robyn Becker, Grace T. Clark, Iyad Ghanim, Kaitlyn Verney, Alexis Gallagher

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Purpose: Although some studies suggest articulatory cues may help enhance early literacy outcomes, research has yet to isolate their specific contribution to the gains. Framed by the motor theory of speech perception (Liberman & Mattingly, 1985), this study seeks to fill this gap by providing phonemic segmentation training using articulatory cues and comparing reading/spelling outcomes to two different comparison groups to attempt to control for the motivation and attention the articulatory cues may provide.

Method: Twenty-seven typically developing four and five year-olds were seen individually for seven weekly sessions during a typical day in a preschool classroom (NCT06504264). The participants …

Effects Of Static Ankle Stretching On Balance And Gait: The Roles Of Age And Parkinson's Disease, Taylor M. Gauss

LSU Doctoral Dissertations

The focus of this dissertation involves the effects of static ankle stretching on balance and gait in adults of different ages and with Parkinson’s disease (PD). A brief introduction in Chapter 1 precedes a detailed literature review in Chapter 2, in which we identify gaps in research on balance and gait following ankle stretching and explain why ankle stretching may serve as a predominant strategy for improving motor performance in aging and PD populations. In Chapter 3, we present the first study identifying whether muscle group selection or stretch duration influences balance in young adults. Results showed that longer durations …

What Is New In Temporary Mechanical Circulatory Support In 2024-2025?, Maya Guglin

The VAD Journal

This review covers the most interesting publications on temporary mechanical circulatory support in 2024-2025. We include the latest research on intra-aortic balloon pumps, Impella devices, and veno-arterial extracorporeal membrane oxygenation.

Innovator - Spring 2026

Innovator

06 - Message From the President

08 - Time Machine

12 - News

22 - Gabrielle Kemberling ’12

28 - The Oughton Family

34 - Beyond the Seams

44 - Question & Innovate

46 - Ram Roundup

48 - Which Ram Was the GOAT?

52 - Class Notes

56 - In Memory

58 - Trivia

Innovator - Fall 2025

Innovator

06 - Message From the President

08 - Time Machine

10 - News

24 - Nureed Saeed ‘99

28 - Cell Mates

32 - Robert C. Sergott, MD

36 - Working Smarter

42 - Question & Innovate

44 - Alumni Impact

48 - Leeor Gal ‘19

50 - Class Notes

56 - In Memory

58 - Trivia

Innovator - Winter 2025

Innovator

06 - Message from the President

08 - Time Machine

10 - News

14 - New Leader for a New Century

18 - Fashion’s Fairy Godmother

22 - Diploma School of Nursing

26 - Question & Innovate

28 - Alumni Impact

30 - Ram Roundup

32 - From the Washington Ballet to Wimbledon

36 - Homecoming 2024 and Alumni Awards

42 - JCLS Alumni Day

44 - Class Notes

50 - Love Train

52 - In Memory

54 - Trivia

Innovator - Summer 2024

Innovator

06 - A Message from the President

10 - Time Machine

16 - The Nexus

32 - Our History

38 - Weaving a Legacy of Excellence

40 - Bridging the Gaps

44 - Harnessing the Qualities That Create Healthcare Heroes

48 - Question & Innovate

52 - Alumni Impact

54 - Ram Roundup

58 - Be Kind

62 - Class Notes

68 - In Memory

70 - Trivia

Innovator - Fall 2023

Innovator

06 - Get to Know Jefferson's Interim President

08 - Leadership Announcements

10 - Time Machine

14 - The Nexus

22 - Climate Change on Your Block

30 - Humana and Jefferson

34 - Question & Innovate

38 - Caffeinated Creativity

42 - Alumni Impact

46 - Ram RoundUp

50 - Brotherhood's Enduring Legacy

56 - Class Notes

60 - In Memory

62 - Trivia

Evaluating Clinical-Academic Partnerships In Physical Therapy Education: A Critically Appraised Topic On Available Assessment Tools, Jocelin Friedman, Hannah Bennett, Rachel Atkinson, Leona Hidalgo

Pacific Journal of Health

Scenario: Physical Therapy Clinical Education represents a significant component of curricula and requires cooperation between academic institutions and clinical education sites (CES). Curriculum structure variation, clinical instructor availability, and student internship demands impact the academic institutions and CES partnership. For stakeholders, communication of expectations and the individuality of the student placement workflow can strain partnerships. Longevity of the clinical-academic partnership depends on effective evaluation incorporating perspectives of both parties. Question: Are there bi- directional assessment tools or protocols available to help academic institutions and CES to evaluate each other in the areas of administrative and collaborative performance? Methods …

Hypothermia Prevention In Major Trauma Patients, Alaina Hostetler

Doctor of Nursing Practice Scholarly Projects

Traumatic injuries present a significant health challenge for providers, often resulting in hypothermia, coagulopathy, and acidosis, referred to as the trauma triad of death. Hypothermia significantly impacts trauma patients' outcomes and exacerbates morbidity and mortality rates, particularly in trauma cases with high injury severity scores who require immediate surgical intervention. Despite the detrimental effects of hypothermia, evidence-based approaches to treating hypothermia in this population are lacking. Traditional warming methods heavily rely on provider preference and can lead to inconsistent care. Rapid, reliable, and effective resuscitation interventions are essential in the immediate care of major trauma patients. The proposed project will …

Dexmedetomidine (Precedex) Versus Propofol: In Patients Requiring Sedation While Mechanically Ventilated,, How Does The Use Of Dexmedetomidine (Precedex) Compared To Propofol, Affect Reintubation Within 48 Hours Post Extubation?, Kimberly Barbee, Markela Albright, Malak Amro, Evelyn Caty-Pletcher, Margaret Havey Phd, Aprn, Acnp-Bc, Chfn, Fhrs, Tracy Mcclinton Dnp, Aprn, Agacnp-Bc, Hget-C, Ebp-C

Doctor of Nursing Practice Projects

Keywords: dexmedetomidine, propofol, reintubation, sedation2

Abstract Assignment

Background

Sedation management in the ICU plays a key role in extubation readiness and post-extubation outcomes in mechanically ventilated patients. Although both propofol and dexmedetomidine are commonly used in critical care, there is limited evidence comparing their impact on early reintubation. This quality improvement (QI) project examined whether sedative choice was associated with reintubation within 48 hours of extubation.

Methods

A retrospective QI analysis was conducted in a cohort of 38 mechanically ventilated adult patients. Patients received either propofol (n = 31) or dexmedetomidine (n = 7) prior to extubation. Reintubation within …

The Importance Of Holistic Care: The Development And Implementation Of Spiritual Resources For Caregivers And Staff At Joni’S House El Salvador, Chloe Veilleux

Capstone Projects

It is within the occupational therapy (OT) scope of practice to not only address client needs related to mind, body, and spirit, but also those of caregivers as a means of fostering overall improved quality of life. Additionally, when OTs address spirituality and implement spiritual/spirituality-informed interventions, correlations of improved psychosocial factors such as well-being, motivation, and reduced stress have been shown, as well as improved hope and reduced burden for caregivers. There remains, however, a gap in the research and implementation of spiritually informed care and resources specifically as it pertains to caregivers of those with disabilities. To address this …

Himmelfarb Library Liaison Letter - April 2026, The George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Shsp Dean's Newsletter, Spring 2026, Robert W. Amler

SHSP Dean’s Newsletter

No abstract provided.

Supporting School Readiness: A Visual-Motor Integration Program For Children Ages 2.5-10, Bailey Williams, Wendy Tremaine, Carla Hamilton

Spring 2026 OTD Capstone Symposium

This capstone project focused on supporting school readiness through the development and implementation of a visual-motor integration (VMI) program for children ages 2.5–10 with developmental delays. A needs assessment was conducted to identify gaps in caregiver knowledge and resources related to VMI development. In response, a 6-week educational program was created, incorporating targeted activities and caregiver education to promote VMI skill development. Findings indicated improved caregiver understanding of VMI concepts and increased confidence in implementing strategies at home. These results highlight the importance of early intervention and caregiver involvement in supporting children’s academic readiness and overall developmental outcomes.

Depressive And Anxiety Symptomatology Among Caregivers Of Children 0-3 Years In Nairobi City County: Community-Based Prevalence Study, Esther Chongwo, Japhet Adina, Kevinson Mwangi, Tabitha Shali, Edwin Dzoro, Cynthia Shitote, Vibian Angweny, Rachel Odhiambo, Margaret Kabue, Amina Abubakar

Institute for Human Development, East Africa

Caregivers of young children in low-resource urban settings face multiple stressors, which can affect their mental health. There is limited population-based evidence on the prevalence and correlates of depression and anxiety among caregivers of young children in these contexts. This study assessed the prevalence and associated factors of depressive and anxiety symptoms among caregivers of young children in Nairobi City County. We conducted a cross-sectional household survey with 2,903 primary caregivers of children 0–3 years. Depressive and anxiety symptoms were assessed using validated Swahili versions of the Patient Health Questionnaire-9 and the Generalised Anxiety Disorder-7, respectively, with a cut-off score …

Navigating Academic Promotion: Identifying The Winning Combination For Volunteer Faculty, Enam Haddad, Jacqueline Hill, Sarah Tsai, Ruba A. Abdelhadi, Sarah Braet, Eric T. Rush

Posters

Introduction/Background: Academic promotion is an arduous and time-consuming process. Implementation of support resources is essential for faculty success. Supporting faculty through the process, we developed multiple promotion resources, including a robust online resource catalogue, peer coaching sessions, and detailed weekly email reminders. Goals/Hypothesis: To examine which resources faculty find most helpful in preparing their academic promotion application. Methods/Approach: We surveyed promotion applicants from 6 cycles (2020-2025). Faculty rated the usefulness of promotion resources, how prepared they felt at different points in the promotion timeline, and provided feedback about the overall promotion preparation process. Results/Outcomes: 258/354 (73%) applicants responded to the …

Can Mentoring Improve Professional Skills For Mentors And Mentees?, Emilie Keeton, Msod, Myles Chandler, Eric T. Rush, Susan B. Hathaway, Jacqueline Hill

Posters

Introduction/Background: We implemented a structured 10-month mentoring program at our pediatric academic hospital designed to assist faculty in actualizing professional and personal goals through developing trusted, mutually rewarding relationships. Goals/Hypothesis: To evaluate if faculty participants in the 2 inaugural mentoring program cohorts improve scores on 6 behavioral competencies related to maintaining effective communication, aligning expectations, assessing understanding, addressing diversity, fostering independence, and promoting professional development. Methods/Approach We used pre- and post-program Mentoring Competency Assessments to assess changes in 26 skills across 6 competencies and gather feedback on program elements from participants. Results/Outcomes: 19/35 (54%) mentees and 15/29 (52%) mentors completed …