Medicine and Health Sciences Commons^™

Etalanetug (E2814) In Dominantly Inherited Alzheimer's Disease: An Open-Label Phase 1b/2 Study To Assess Safety And Target Engagement In Participants With Mild To Moderate Cognitive Impairment, Erica Andreozzi, Kanta Horie, Nicolas R Barthélemy, Brian A Gordon, Shaney Flores, Tammie L S Benzinger, Eric Mcdade, Randall J Bateman, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Etalanetug (E2814) is designed to delay the clinical progression of Alzheimer's disease (AD) by binding to the microtubule binding region (MTBR) of tau implicated in seeding and spreading of tau pathology. Dominantly inherited Alzheimer's disease (DIAD) is a rare form of the disease (<  1%), having similar changes in the tau distribution and pathology to sporadic AD. Herein, we report the safety, pharmacology and biomarker results of the etalanetug Study 103 in DIAD patients.

METHODS: Study 103 enrolled participants with mild-to-moderate cognitive impairment due to DIAD who received etalanetug intravenously every 4 weeks escalating from 750 mg, 1500 mg, 3000 mg, to 4500 mg. After ascending to 4500 mg, patients received 4500 mg for up to 108 weeks. Tau pathology biomarkers, ptau217 and MTBR-tau243 were measured in CSF. Additional …

From Vision To Impact: Building A Sustainable Open-Access Peer Reviewed Medical Journal, Darshana T. Shah Phd

All Things Open

The Marshall Journal of Medicine (MJM) was created to strengthen scholarly exchange, clinical innovation, and health professions education in rural Appalachia while making that work openly accessible to readers worldwide. As West Virginia’s first fully open‑access, online, peer‑reviewed medical journal, MJM illustrates how a mission‑driven publishing effort can evolve from an initial idea into lasting scholarly infrastructure—and how publication activity can translate into measurable impact.

MJM’s development centered on three strategic pillars:

• a clearly articulated scope focused on clinically relevant and educationally innovative scholarship
• rigorous peer‑review and editorial practices that ensure credibility and quality
• operational partnerships—especially with academic …

Examining The Benefits Of A Standardized Protocol For Hyperglycemia Screening In Adult Oncology Patients: A Pilot Study, Alexa Dashko

Pacific Journal of Health

Many individuals receiving cancer directed therapy are at risk of developing hyperglycemia and new, or worsening of, diabetes due to location of their cancer, treatment regimen, and/or prolonged use of steroids. Research shows that uncontrolled hyperglycemia can have detrimental effects on individuals’ response to cancer therapy, treatment associated toxicities, quality of life and overall mortality. Despite extensive research identifying the need for routine monitoring and management of hyperglycemia in oncology patients, medical societies have yet to establish formal screening guidelines for practitioners. The aim of this pilot study was to examine the outcomes of establishing a protocol for screening and …

Dermal: A Multi-Input Deep Learning Model For Improving Access To Dermatological Screening, Aubreye Freeman

ATU Scholars Symposium

According to the World Health Organization's press release on December 12, 2024, global healthcare spending is dropping significantly, leaving a large percentage of the world without proper healthcare. In an attempt to alleviate this problem, with respect to the field of dermatology, we created a deep learning model, Dermatology Enhanced by Recognition and Machine Aided Learning (DERMAL), to assist in diagnosing skin conditions. DERMAL was trained on a portion of the Google and Stanford Medicine's SCIN dataset, which has more than 10,000 images of various skin conditions. The 9 most common skin conditions of the dataset were selected as the …

Car-T Cell Therapy – A Revolutionizing Cancer Treatment Through Precision Immunotherapy, Mackenzie R. Epperson

ATU Scholars Symposium

Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a great advancement in the field of oncology, offering a targeted and adaptable cancer treatment. Traditional therapies, including surgery, chemotherapy, and radiation often have limitations, such as relapse and resistance, highlighting the need for more precise therapeutic options. CAR-T therapy addresses many of these challenges through engineering a patient’s own T-cells to recognize and destroy cancerous cells with specificity and long-lasting immune activity. Since being approved by the FDA in 2017, CAR-T therapy has shown success in treating hematologic malignancies, demonstrating high remission rates in patients with previously limited options. Despite …

Investigating The Effect Of Kcl Stress In Raphanus Sativus, Mason P. Oelke

ATU Scholars Symposium

Presented by Stephanie Nelms at the Arkansas INBRE Conference on November 7-8, 2025.

Presented by Mason Oelke at Arkansas Tech Scholar's Symposium on April 9th, 2026.

Potassium is an essential macronutrient for plant growth and development, yet excessive potassium fertilization can induce salt stress with detrimental consequences for crop productivity and nutritional quality. Despite its agricultural relevance, potassium chloride induced stress remains significantly understudied compared to classical sodium-based salinity. This thesis investigates the physiological, biochemical, and molecular responses of Raphanus sativus to KCl stress using an integrated approach that combines germination assays, mineral profiling, and gene expression analysis.

Radish seeds …

When The Caregiver Becomes The Wounded, Gracelin L. Young

ATU Scholars Symposium

Burnout among critical care nurses (CCNs) is a substantial threat to nurse well-being, patient safety, and workforce stability. The aim of this paper is to identify risk factors contributing to burnout in CCNs using evidence-based articles. An organized literature search was conducted using CINAHL with key terms including critical care nurses, burnout, risk factors, compassion fatigue, and work environment. Five recent peer-reviewed studies meeting inclusion criteria were chosen. The results validate that risk for burnout is vastly influenced by emotional exhaustion, chronic workplace stress, high patient acuity, sleep disturbances, compassion fatigue, insufficient support, and organizational strain. Findings suggest that burnout …

Re-Purposing Pre-Existing Tilapia Aquaculture Open-Design System For Zebrafish Biomedical Research Purposes, Luke Cantu, David Sierra, Skyleigh Curtis, Maya Avila

ATU Scholars Symposium

Title: Re-purposing pre-existing tilapia open-design aquaculture systems for zebrafish biomedical research purposes.

Background: Zebrafish (Danio rerio) models are gaining popularity in biomedical research; however, the high infrastructure cost, at approximately $20,000 per unit, is a significant hurdle for primary undergraduate institutions (PUIs) establishing zebrafish facilities. This study assesses if repurposing existing tilapia open-design aquaculture systems could be a cost-effective method for zebrafish facility establishment.

Methods: Between November-2025 to February-2026, the study used a pre-existing tilapia aquaculture open-design system with personnel modified outlet filters. The water quality of this system was monitored and recorded. The study compared the stabilization phase or …

Examining Outcomes Of Client Education Interventions To Reduce Caffeine Intake In The College-Age Population, Mackenzie Leonard, Mikayla Evans

James Madison Undergraduate Research Journal (JMURJ)

This scoping review aimed to explore health interventions that address excessive caffeine consumption in college students aged 18–23 years. Excess caffeine intake is associated with a range of health concerns, including neurological, cardiovascular, and behavioral issues, highlighting the need for effective interventions to mitigate its impact on overall wellness. The literature exploring interventions aimed at modifying health behaviors among the college student population is notably limited. Furthermore, there has been a lack of studies replicating interventions aimed at reducing caffeine intake. These gaps suggested the need for further investigation and exploration of reports pertaining to health promotion. The results of …

Maladaptive Influences Of Direct-To-Consumer Pharmaceutical Advertising: The Moderating Influence Of Age And Consumer Loneliness, Sanjay Puligadda

Atlantic Marketing Association Proceedings

No abstract provided.

Caring For Caregivers: A Health Care Marketing Opportunity, Yvette Lynne Bonaparte Dr.

Atlantic Marketing Association Proceedings

No abstract provided.

Genotype-Dependent Response Of Huntington’S Disease Cells To Non-Contact Picosecond Pulsed Electric Fields (Pspef), Augustine U. Anthony, Mackenzie A. Tardif-Kunk, Martina Zamponi, Peter A. Mollica

Knowledge and Creativity Expo

Non-Contact Picosecond Pulsed Electric Fields (psPEF) improved metabolic function in mutant Huntington diseased isogenic cell lines.

Predictors Of Stress Among Bsw And Msw Students At Fhsu, Octavio Ramirez, Annette Clarke Jones

SACAD: Scholarly Activities

Chronic stress leads to severe health consequences, including anxiety, depression, burnout, and physical issues like fatigue and sleep disturbances. This study examined factors predicting stress among a sample (n = 101) of BSW and MSW students attending FHSU. The findings showed that sexual orientation, academic grade point average, and marital status were significant predictors of stress among this sample.

Reirradiation Treatment Effects In The Clinic (Retec) Proposal - Proof Of Concept Based On Spinal Cord Dose Tolerance For Reirradiation With Stereotactic Body Radiotherapy, Jimm Grimm, Anand Mahadevan, Olusola Obayomi-Davies, Scott G. Soltys, Arjun Sahgal, Kristin J. Redmond, Michael T. Milano, Wolfgang A. Tomé, Kenneth Brooks, Scott Dodd, John Austin Vargo, Gopal Subedi, Jinyu Xue, Bisher Ebid, Felix Ehret, Byung-Han Andrew Rhieu, Christoph Fürweger, Rachel Grimm, Alexander Muacevic, Vitali Moiseenko, Shalom Kalnicki, Mark Mclaughlin, Lawrence R. Kleinberg, John R. Adler, Iris C. Gibbs

College of Health Professions Faculty Papers

BACKGROUND: Since the inception of spinal radiosurgery decades ago, the factors influencing spinal cord recovery have remained unclear. Elucidating these factors would aid in reirradiation planning and delivery. We describe modeling reirradiation normal tissue complication probabilities (NTCP) from compiled published data, akin to the collaborative Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) and High Dose per Fraction, Hypofractionated Treatment Effects in the Clinic (HyTEC) projects.

PURPOSE: Simple dose-time recovery factors for the spinal cord serve as a basis to propose the Reirradiation Treatment Effects in the Clinic (ReTEC) project. ReTEC aims to define human organ recovery factors …

Onboarding And Resource Guide Development At Lipscomb University Ideal Program, Folasade S. Alalade

OTD Capstone Projects

The Lipscomb IDEAL program is a two-year inclusive postsecondary program that supports young adults with intellectual disabilities in areas such as education, employment, and independent living. Following the IDEAL program, students have the opportunity to continue their postsecondary experience through the Advanced Program (AP), where they further develop skills. This capstone project focused on creating onboarding materials for students and families transitioning from the IDEAL program to the AP in order to better support and prepare them for this next phase. The second component of the project involved researching assistive technology (AT) and artificial intelligence (AI) tools beneficial to this …

Connectivity, Classroom, And Contagion: An Ecological Analysis Of Testing Availability, Sex Education, And Sti Rates In The Upper Midwest, Macey M. Boerhave

Honors Thesis

Rural and frontier communities in the Upper Midwest face unique challenges that shape how young people access sexual health information and testing. While sexually transmitted infection (STI) rates continue to rise nationally, less is known about how sexual health education, digital access, and geographic distance influence these trends at a county level. This study examines the relationship between broadband internet access rates, poverty rates, proximity to free or low-cost STI testing sites, and county-level STI rates among individuals aged 15-24 in selected counties across South Dakota, North Dakota, Minnesota, Iowa, and Nebraska. Using an ecological, cross-sectional design, county-level STI surveillance …

Utility Of Right Ventricular Mass Ratios In Recipients With Pulmonary Hypertension: A United Network For Organ-Sharing Database Analysis, Matthew P. Weber, Danial Ahmad, Howard J. Eisen, Eugene Storozynsky, René J. Alvarez, J. Eduardo Rame, Keshava Rajagopal, John W. Entwistle, Charles Hoopes, Vakhtang Tchantchaleishvili

Division of Cardiology Faculty Papers

PURPOSE: There is a lack of data reviewing the role of predicted cardiac mass ratio (PCMR) in transplant recipients with pulmonary hypertension (PH). In particular, the right ventricular (RV) mass ratio (RVMR) is a component of PCMR not yet studied separately for this purpose. We aimed to review the relationship of PCMR and RVMR with PH in terms of post-transplant overall survival.

METHODS: The United Network for Organ-Sharing (UNOS) database was queried for primary heart transplant (HTx) patients from 2004 to 2023. Predicted RVMR was calculated for donors and recipients. A parsimonious multivariable model Cox model was formed for risk …

Addressing Financial Toxicity In Student-Run Free Clinics (Srfcs) Through Development Of Inventory System And Community Resource Guide For Durable Medical Equipment (Dme), Samantha Boggess

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Student run free clinics (SRFC) provide care to uninsured or under insured patients with physical and mental health impairments. Under insured patients must make difficult decisions about their healthcare, not based on best practices, but on what they can reasonably afford.  For example, they may have to forego durable medical equipment (DME) (e.g., shower chairs, wheelchairs, and self-care equipment)or treatments due to high out-of-pocket costs.

Financial toxicity (FT) refers to the negative impact of medical expenses on patients’ health-related quality of life (HRQOL) and can lead to poor physical and mental health outcomes. FT is a new concept that has …

Effects Of A Major Disruption On Mental Health Of Pregnant Women In South Carolina, Lizmarie Maldonado

MUSC Theses and Dissertations

Mental health conditions are a leading cause of death among pregnant and postpartum women, and untreated mental health conditions are associated with adverse maternal and birth outcomes. Major disruptions, such as pandemics, hurricanes, or wildfires, create unprecedented challenges and may impose additional stressors during an already vulnerable time. Community or medical care disruptions during such events may lead to adverse health outcomes. This dissertation seeks to characterize the impact of a recent major disruption on mental health outcomes among pregnant women using administrative claims data for all births in South Carolina in 2019 and 2020. By leveraging unique data sources, …

Suena Como Nosotros: A Spanish-English Storybook For Growing Voices, Stephanie Czajka

Undergraduate Theses

The purpose of this project is to address the lack of speech therapy resources available to bilingual Spanish-English-speaking children between the ages of four to six. It will target common speech and language difficulties observed in children during the critical language development period, between the ages of four and six. This book will provide an accessible, culturally relevant speech therapy resource that can be used in the comfort of the home. Through the creation of this book, equity in healthcare access will be promoted, and bilingual pride and identity will be supported. The objectives of this project include designing and …

Supporting Positive Interactions With Individuals With Disabilities: A Law Enforcement Guide, Brittany James Jefferson, Mary Jan Greer

Spring 2026 OTD Capstone Symposium

This capstone project developed an educational guide to support law enforcement officers in creating safe and effective interactions with individuals with disabilities. A needs assessment informed the guide’s development, which was grounded in occupational therapy principles and the Person Environment Occupation Performance (PEOP) model. The guide was implemented within a law enforcement setting and evaluated through officer feedback. Findings indicated strong baseline experience among officers, with added value in providing structured strategies to support communication, interpretation, and de-escalation. This project highlights the role of occupational therapy in promoting inclusive, community-based practice.

Enhancing Occupation-Based Engagement For Adults With Idd, Miranda Brown, Mary Jan Greer

Spring 2026 OTD Capstone Symposium

This study aimed to explore the importance of occupation-based engagement for adults with intellectual and developmental disabilities (IDD) through the lens of occupational therapy (OT). Literature review and needs assessments informed the development of client-centered interventions and program modules. Project outcomes highlighted the benefit of increased opportunity and appropriate grading of occupation-based engagement for adults with IDD, as well as education for community-based site staff and caregivers.

Play For All: Promoting Inclusivity And Providing Modifications For Kids With Disabilities Within An Indoor Play Space, Yasmeen Ikbal, Mary Jan Greer

Spring 2026 OTD Capstone Symposium

Children’s environments need to be enhanced to match their developmental levels (Winter & Dempsey, 1994). There is a lack of tools, play equipment, and structures specifically targeted to children with disabilities (Therrien et al., 2022). Lack of opportunities for these children can hinder their development (Mullick, 2013). This capstone intends to educate staff and parents on how to promote inclusivity by increasing their understanding of disabilities, creating accessible environments, adapting activities, and building confidence in supporting children with disabilities to participate in their occupations.

Medication Nonadherence And Social Participation For African American Adults With Low Vision, Shakeda Mcghee, Mary Jan Greer Phd, Otr, Jaimee Fielder

Spring 2026 OTD Capstone Symposium

The concept of this capstone is to analyze how quality of life (social participation, health management) is affected in adults ages 18-55 with low vision/blindness with conditions to include diabetic retinopathy, glaucoma, and cataracts.

Correspondence: Dean Elizabeth Martin And Frenesi Wilson Concerning Employment, Dr. Elizabeth Martin, Frenesi Wilson

Correspondence

Correspondence between Dr. Elizabeth Martin, dean of the School of Nursing at the University of North Alabama and Frenesi Wilson, PhD candidate at the University of Texas-Austin, concerning employment. Within in this November and December 1975 correspondence, Frenesi Wilson decline's Dean Martin's offer of a faculty position as an assistant professor due to the commitment of her PhD program. However, Dr. Wilson eventually joins the program as dean on July 19, 1976.

Pamela Charlene Kennamer: Nursing Student Correspondence, License & Pin, Pamela Charlene Kennamer

Correspondence

Correspondence pertaining to nursing student Pamela Charlene Kennamer Corble's admittance to Florence State University as a transfer student in May of 1973. Kennamer was a member of one of UNA's, formerly Florence State University, first graduating classes in nursing. Documents in the final pages of the pdf, include her registration for the state nursing exams in 1976 and official license and nursing pin.

Conceptual Framework With Annotations, College Of Nursing, Florence State University

Documents

The document includes the conceptual framework for the School of Nursing at Florence State University dated April 27, 1976. It also features several handwritten annotations that amend and reword portions of it dated July 21, 1996. Overall, the framework argues the impact of the nursing school's interactions with broader society in helping its students reach self-actualization through its pedagogical practices.

Poems By Nursing Students, Anonymous, A. Jann Davis, L M. A, Larry Atkins

Documents

A series of four poems presumed to be authored by nursing students in approximately the 1980s on themes related to mortality and grief.

The first poem "Thoughts of a Dying Person" is written by an anonymous author whose speaker questions the things in life they would do differently if they had more time. Its form is more prose like than the others in the document and could be considered flash fiction or prose poetry but seems to fit the poetic category more through the usage of a triangular shaping of the poem.

The second poem, an untitled piece by A. …

Information Sheet For High School Day, School Of Nursing, University Of North Alabama

Documents

Information sheet prepared by the University of North Alabama Student Nurses' Association for High School Day held on November 17, 1976. The document explains the School of Nursing's founding in 1973 and the admission process for those seeking a Bachelor of Science in Nursing (BSN).

Integrating Zotero With Your Writing: From Research To Publication – Hslic Workshop Apr 2026, Evelyn Wang

HSLIC Faculty and Staff Instructional Resources

This HSLIC workshop presentation provides a practical, step‑by‑step guide to integrating Zotero into the research and writing workflow. Topics include installing and configuring Zotero and the Zotero Connector, collecting references from databases and web pages, organizing items with collections, subcollections, tags, and PDF attachments, inserting citations and generating bibliographies in Microsoft Word and Google Docs, managing and annotating PDFs, handling title case versus sentence case, detecting and merging duplicate records, and using advanced features such as Zotero sync, group libraries, collaboration tools, custom citation styles, and ZoteroBib.