Medicine and Health Sciences Commons^™

Synthetic Lethality Of Decitabine Plus Atr Inhibition For Tp53-Mutated Aml, Jeremy T Baeten, Sumedha Agashe, Imene Tabet, Jack T Wooldridge, Amber Carter, Jamie N Butler, Christopher A Miller, Nicole Helton, Annabel Quinet, Kimberly B Johansson, Yichan Yang, Geoffrey L Uy, Alessandro Vindigni, Daniel C Link

2020-Current year OA Pubs

TP53 mutations are found in 10% to 15% of myeloid neoplasms and are associated with a dismal prognosis. Although hypomethylating agents (HMAs), such as decitabine, are active in TP53-mutated myeloid neoplasms (TP53-MN), mutation clearance is rarely complete and nearly all patients relapse. Molecular determinants of response to HMAs in TP53-MN are poorly understood. Here, we show that decitabine induces replicative stress with decreased replication fork progression, induction of single-strand DNA breaks, and activation of the ataxia telangiectasia mutated-Rad3-related (ATR) pathway. Resolution of decitabine-induced replication stress is impaired in TP53-mutated acute myeloid leukemia (AML) cells, representing a potential therapeutic vulnerability. Indeed, …

Enhanced Dietary Monitoring Using Fecal Genomics For Childhood Malnutrition Interventions, Ammara Aqeel, Najeeha T Iqbal, Sanam Iram Soomro, Sheraz Ahmed, Teresa K Mcdonald, Olivia Osborne, Sharon Jiang, Nolan Ives, Kazi Ahsan, Fayaz Umrani, Michael J Barratt, Jeffrey I Gordon, Syed Asad Ali, Lawrence A David

2020-Current year OA Pubs

Ready-to-use therapeutic and supplementary foods (RUTF/RUSF) are a primary treatment for childhood malnutrition in Community Management of Acute Malnutrition (CMAM) programs. However, measuring intervention compliance is labor intensive and unreliable. We applied FoodSeq, a fecal genomic dietary assessment biomarker, in malnourished infants (3-15 months) from Matiari, Pakistan. FoodSeq identified a significant increase in the abundance of DNA from chickpea, a primary RUSF ingredient, during RUSF administration and captured region-specific complementary feeding practices, including age-inappropriate feeding practices such as wide-spread tea consumption. Our findings highlight the potential of dietary genomics as an empirical and scalable tool for compliance monitoring and dietary …

Herpes Simplex Virus Type 1 R-Loops Are Targets For Apobec-Mediated Mutagenesis, Márton Miskei, Dóra Varga, Lilla Hornyák, Éva Sipos, Éva Nagy, Qiuzhen Li, Zsolt Karányi, Zoltán Szabó, Rachel Deweerd, Abby M Green, Dávid Szüts, Eszter Csoma, Lóránt Székvölgyi

2020-Current year OA Pubs

APOBEC3 enzymes are key effectors of antiviral immunity that introduce mutations into viral genomes. We show that viral R-loops serve as preferred substrates for APOBEC3-mediated mutagenesis during herpes simplex virus type 1 (HSV-1) infection. APOBEC3 enzymes are recruited to viral R-loops, generating clustered C-to-T mutations in genes critical for viral assembly. Importantly, R-loops alone are not mutagenic, and APOBEC3 enzymes do not edit HSV-1 without an R-loop; mutagenesis occurs when R-loops and APOBEC3 enzymes interact. These findings identify endogenous R-loops formed during the HSV-1 life cycle as focal vulnerabilities and highlight R-loop-APOBEC3 coupling as a mechanism for antiviral mutagenesis.

Dr. Mark Crabtree Puts Community Service At The Forefront Of His Profession, Mackenzie Meleski

Virginia Dental Journal

No abstract provided.

Awards And Recognition

Virginia Dental Journal

No abstract provided.

Mountain Empire Community College Sponsors Fourth Annual Give Kids A Smile! Day, Emily Kate Bowen Dds, Ma, Mph

Virginia Dental Journal

No abstract provided.

Creating A Brand Identity For Your Dental Practice, Kelly O'Keefe

Virginia Dental Journal

No abstract provided.

What Patients Believe — And What They're Actually Doing, Michael Weitzner Dds

Virginia Dental Journal

No abstract provided.

The Dental Oenophile, Zaneta Hamlin Dds

Virginia Dental Journal

No abstract provided.

Virginia Board Of Dentistry Meeting Notes March 6, 2026, Ursula Klostermyer Dds, Phd

Virginia Dental Journal

No abstract provided.

Practicing Ethical Patient Selection: Applying The Ada Principles In Everyday Care, Adel Rizkalla Dds

Virginia Dental Journal

No abstract provided.

Through The Looking Glass, Sarah Glass Dds, Leigh Griffin Dds

Virginia Dental Journal

No abstract provided.

An Examination Of Hiring Practices And Employee Retention Today Compared With Pre-Pandemic Characteristics In Orthodontics, Logan Passey Dds, Msd, Bhavna Shroff Dds, M.D.Sc., Mpa, Christina B. Philips Dds, Msd, Caroline K. Carrico Ph.D., Steven J. Lindauer Dmd, M.D.Sc, Daniel R. Hawkins Dmd, Siddharth Chiang Dds

Virginia Dental Journal

The COVID-19 pandemic resulted in a fundamental shift in the labor market, leading to unprecedented job losses. Between February and April 2020, approximately 22.2 million jobs were lost nationwide. Notably, dentistry was among the top ten industries impacted, accounting for 555,000 of those job losses. When positions were reopened, only 76% of all employees across all industries returned to work by August 2020.

As the COVID-19 pandemic dramatically disrupted workforce stability, particularly within dental practices, effective talent management emerged as a critical strategy for rebuilding and sustaining the dental workforce. Talent management is of increasing importance in today’s labor market, …

2026 Virginia Dental Showcase, Megan Wyman

Virginia Dental Journal

No abstract provided.

The Fulcrum Podcast, Shannon Jacobs

Virginia Dental Journal

No abstract provided.

2026 Dental Days At The Capitol: When Vda Members Unite, The Impact Is Powerful, Laura Givens

Virginia Dental Journal

No abstract provided.

Thank You For Standing With Organized Dentistry, Scott Berman Dds

Virginia Dental Journal

No abstract provided.

2026 General Assembly Session Review, Tripp Perrin, Emily Ward, Missy Wesolowski

Virginia Dental Journal

No abstract provided.

The Intersection Of Artificial Intelligence And State Dental Board Regulations An Emerging Area In 2026, Paul Supan Dds, Rick Jackomis Dds, Jd, Munira Muluke Dmd, Ms

Virginia Dental Journal

No abstract provided.

The Drill, Episode 23, Ryan Dunn

Virginia Dental Journal

No abstract provided.

New Leadership, Shared Vision: Ada’S Next Chapter Begins, James Mercer Dds

Virginia Dental Journal

No abstract provided.

Please Join Us, Sarah Friend Dds

Virginia Dental Journal

No abstract provided.

A United Voice For Virginia Dentistry, Marlon Goad Dds

Virginia Dental Journal

No abstract provided.

Va Dent J April, May And June 2026

Virginia Dental Journal

This issue of the Virginia Dental Journal highlights the key forces shaping dentistry in 2026, including workforce shortages, legislative advocacy, and emerging technologies. It examines the impact of artificial intelligence on clinical care and regulation, alongside ongoing efforts to expand access to care and strengthen the dental workforce in Virginia. The issue also addresses changes in professional engagement, practice management trends, and the importance of organized dentistry in navigating policy and industry challenges. Overall, it underscores a profession adapting to rapid change while prioritizing patient care and collaboration.

Pages Of Despair: Economic Policy Uncertainty And Mental Health, Kori Massner

SACAD: Scholarly Activities

Policy uncertainty threatens access to affordable medical care, yet few studies have examined how it shapes what people search for online. This study examines whether economic policy uncertainty predicts mental health information-seeking behavior by analyzing daily Wikipedia pageviews from July 2015 to April 2026 using a time series model. Results show that as economic policy uncertainty increases, there is an increase in pageviews on Wikipedia for suicide related information. When there is an increase in those searching for information on pages about depression and pages about anxiety, there is also an increase in pageviews on Wikipedia for suicide related information. …

Manual Audiometry Vs. Iphone Hearing Test: A Comparative Analysis Of Hearing Screening Results, Kelsi White, Mckayla Sprague, Jennifer Sadler, Blake Roth

SACAD: Scholarly Activities

This study examined differences in hearing screening outcomes between manual audiometry and the iPhone Hearing Test using Apple AirPods Pro (2nd generation) among 30 adults. Participants completed pure-tone threshold screenings at frequencies ranging from 250 Hz to 8000 Hz in a sound-treated audiology suite. Manual audiometry followed a modified Hughson-Westlake procedure, while the automated test used Apple’s standardized protocol. After both screenings, participants reported perceptions of accuracy, convenience, and preference through a questionnaire. Results from the screenings and surveys provided insight into participant trust, perceived reliability, and the practicality of smartphone-based hearing tests compared to traditional methods. Findings highlight the …

Finding Her Voice: Communication Challenges And Strategies Among Young Women With Autism Spectrum Disorder, Sydney Holthaus, Averi Yeo, Madison Walt, Ran An

SACAD: Scholarly Activities

Background/Rationale

Research on autism spectrum disorder (ASD) has historically centered on males, leaving the communication experiences of autistic females underrepresented (Lai et al., 2015). Although autistic females make up a substantial portion of the autistic population in the United States (Centers for Disease Control and Prevention, 2023), far less is known about how communication differences affect their everyday lives. Diagnostic processes may also overlook communication-related signs in autistic women, particularly when masking or compensatory behaviors reduce the visibility of underlying pragmatic and social communication differences (Dean et al., 2017; Hull et al., 2020; Rynkiewicz et al., 2018). As a result, …

Familybloom: Examining Ecologies Of Collaboration In Family-Centered Health Tracking, Lucas M. Silva, Aehong Min, Evropi Stefanidi, Franceli L. Cibrian, Jesus A. Beltran, Cassie Zeiler, Sabrina E. B. Schuck, Kimberley D. Lakes, Gillian R. Hayes, Daniel A. Epstein

Engineering Faculty Articles and Research

Family health informatics tools can help support well-being with shared data tracking. Prior work typically focused on shared data review, but often in specific moments, like bedtime, or centered on caregiving of children or elderly members. To investigate how tracking can support mutual health collaboration between family members pervasively across daily contexts, we designed and deployed FamilyBloom, a glanceable smartwatch and home display system for mood and goal tracking. Twelve families with both neurotypical and ADHD members used FamilyBloom for three months on average. Our findings reveal how family-centered tracking created collaboration opportunities and tensions across multiple ecological systems: individual …

Effectiveness Of The Mediterranean Diet For Sustained Weight Maintenance Following Glp-1 Medication Discontinuation: A Longitudinal Prospective Study, Nitya Reddy, Josephine Thomas, Julie Salam

Department of Nutrition Student Projects

Glucagon-like peptide-1 (GLP-1) receptor agonists are effective for short-term weight reduction in adults with obesity, yet weight regain is frequent after discontinued use of the medication. Identifying sustainable dietary approaches that support long-term weight maintenance is imperative. The Mediterranean diet has been associated with improving metabolic health and resistant weight control, suggesting it may be an effective strategy for the transition off GLP-1 therapy. Men and women ages 45-55 that are diagnosed with Type 2 diabetes and receiving GLP-1 receptor therapy are the targets of this study, specifically those who plan to discontinue medication within the next three months. On …

Oral Butyrate Supplementation In Patients With Als: Impact On Gut Microbiota And Disease Progression, Annabelle Keller, Kaydee Kinnett, Camaryn Barbanel, Trinity Blakeney

Department of Nutrition Student Projects

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron loss. Emerging evidence suggests that alterations in gut microbiota—particularly reductions in butyrate-producing bacteria—may contribute to neuroinflammatory pathways involved in disease progression. Observational studies in patients with ALS and preclinical findings from transgenic mouse models demonstrate gut microbial dysbiosis, intestinal barrier dysfunction, and improved survival following butyrate supplementation, suggesting the potential role of butyrate availability in ALS pathophysiology. The present study investigates whether oral butyrate supplementation can modulate inflammatory responses, improve gut microbiota composition, and slow functional decline among patients with ALS. Participants will be recruited from …