Medicine and Health Sciences Commons^™

Effects Of Limb Dominance On Dopaminergic Neurodegeneration In A 6-Ohda Rat Model Of Parkinson’S Disease Assessed By Immunoblotting, Jasin Aziz Porshia, Deanna Chaialee, Dipesh Pokharel, Kala Venkiteswaran, Thyagarajan Subramanian, Dilshan Beligala

ONU Student Research Colloquium

Effects of Limb Dominance on Dopaminergic Neurodegeneration in a 6-OHDA Rat Model of Parkinson’s Disease Assessed by Immunoblotting

Jasin Porshia^a , Deanna Chaialee^a , Dipesh Pokharel^b,c , Kala Venkiteswaran^{b, c, d} , Thyagarajan Subramanian^{b, c, d}, Dilshan Beligala^a

^aDepartment of Biological Sciences, Ohio Northern University, Ada, OH, USA

^bDepartment of Neurosciences and Psychiatry, The University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

^cDepartment of Neurology, The University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA

^dDepartment of Neurology, Howard University, Washington, DC, …

A Single Administration Of Psilocybin Is Ineffective In Reversing Ptsd-Like Sequelae In A Rat Model Of Stress-Enhanced Fear Learning, Kylie M. King, Marisa J. Savini, Noelle M. Molnar, Evelynn J. Schneider, Savannah E. Straub, Joe Parker, Lillianna P. Puppel, Aleece K. Al-Olimat, Allison M. Bach, Phillip R. Zoladz

ONU Student Research Colloquium

Single treatments with psychedelics produce rapid, long-lasting antidepressant effects. Psychedelics may also exert anxiolytic effects and be useful in treating more complex psychiatric conditions, such as PTSD. However, less is known about the impact of these agents on PTSD-related symptoms. Thus, we aimed to determine whether a single administration of psilocybin could reverse PTSD-like sequelae induced by stress-enhanced fear learning in rats. Sprague-Dawley rats were placed in Context A (circular, white conditioning box) and exposed to several uncontrollable footshocks (Stress) or no footshocks (No Stress). The next day, the rats were placed in Context B (square conditioning box with clear …

Psilocybin And The Related Tryptamine, Norbaeocystin, Exert Acute Anxiogenic Effects That Depend On Sex, Marisa J. Savini, Kylie M. King, Noelle M. Molnar, Evelynn J. Schneider, Savannah E. Straub, Joe Parker, Lillianna P. Puppel, Aleece K. Al-Olimat, Allison M. Bach, Andrew Jones, Phillip R. Zoladz

ONU Student Research Colloquium

Single treatments with psychedelics have demonstrated rapid, long-lasting antidepressant effects. However, psychedelics often produce unfavorable psychoactive effects that could worsen existing psychological distress. Thus, we compared the effects of psilocybin and the related tryptamine, norbaeocystin, on anxiety-like behavior in male and female rats. In Experiment 1, rats were treated with 1 mg/kg psilocybin (PSIL), 1 mg/kg norbaeocystin (NOR), or vehicle 30 min before a 5-min trial on an elevated plus maze (EPM) or in an open field test (OFT). On the EPM, PSIL led to decreased open arm time and fewer arm entries in males and females. NOR led to …

Abstract Book (Pdf), Lsu Health School Of Medicine

Medicine Research Day

No abstract provided.

Smartphone Use, Social Media, And Academic Procrastination In Secondary Education: A Multi Method Approach Investigation With Implications For School-Based Interventions, Haslee Sharil Lim Abdullah, Riza Amalia, Henny Indreswari, Im Hambali, Ronal Surya Aditya, Rusnila Rusnila

Buletin Konseling Inovatif

Academic procrastination has become a significant challenge in digital learning environments, particularly among adolescents with high smartphone and social media usage. This study examines the relationship between mobile phone use and academic procrastination among 262 high school students in Indonesia using a cross-sectional survey, narrative review, and network analysis. Results show 75.6% of students exhibit medium and 20.2% high procrastination levels, with "alternative activities" like digital distractions as the main form (M = 15.87, SD = 2.92). No significant differences were found by gender (p = .067) or age (p = .412), but strong positive correlations emerged between gadget use …

Disruption Of The Lrrk2 Substrate Rab12 Facilitates Neurotransmission And Causes Hyperactivity In Mice, Xingjian Li, Yuanxin Chen, Huaixing Wang, Xue Zhang, Noah Guy Lewis Guiberson, Xianting Li, Jacqueline Burré, Junmin Peng, Hui Zhang, Zhenyu Yue

Department of Neuroscience Faculty Papers

RAB12 is a small GTPase and a validated substrate of LRRK2, a kinase genetically linked to Parkinson's disease (PD). While RAB12-LRRK2 signaling has been implicated in ciliogenesis and immune regulation, the neuronal function of RAB12 remains largely unexplored. Here, we investigated the role of RAB12 in synaptic physiology using Rab12 knockout (KO) mice. Rab12 KO mice developed normally but exhibited increased locomotor activity in adulthood. Electrophysiological recordings from striatal slices revealed enhanced presynaptic release probability and increased excitatory drive onto medium spiny neurons. Consistently, live-cell imaging of cultured cortical neurons revealed that Rab12 deletion facilitated, while Rab12 overexpression inhibited, synaptic …

Program And Proceedings, The Nebraska Academy Of Sciences 1880–2026: 146th Anniversary Year, One Hundred-Thirty-Sixth Annual Meeting

Nebraska Academy of Sciences: Programs and Proceedings

Program and abstracts of the proceedings for the Nebraska Academy of Sciences 136th annual meeting, 2025

Sessions

Aeronautics and Space Science

Anthropology

Biological and Medical Sciences

Earth Sciences

Ecology, Sustainability, and Environmental Science

Physics and Engineering

General Poster Session

2026 Maiben Lecture: Shifting Extremes: Understanding Nebraska’s Changing Climate and Preparing for What Lies Ahead, Deborah Bathke

2026 Friends of Science Awards: Julie Shaffer and Irina Filina

2026 C. Bertrand and Marian Othmer Schultz Colleaguate Schoalrship Award: Piper Ryschon and Bryce Reeson

In Memoriam: Paul Royster

Public Perception Of Equine Rabies And Its Implications For Future Education And Preventative Strategies, Kya Walton

Honors College Theses

This study examined the rabies knowledge, vaccination, and risks of exposures of horse owners/overseers across the state of Kentucky. Research was conducted to determine the need for public health educators and veterinarians to inform the public on rabies. Survey results concluded that respondents' general knowledge of rabies transmission and mortality rate was respectable, but knowledge relating to equine vaccination was comparatively lower. A weak inverse relationship was observed between general rabies knowledge and concern over an individual’s horses contracting rabies. A weak positive correlation was determined when looking into general rabies knowledge and the likelihood of vaccinating an individual’s horses. …

Ethnicity, Culture, And The Epidemiology Of Eating Disorders, Rebecca Atwell

Honors Theses

This systematic literature review addresses the research question: How does culture affect eating disorders? It examines the role of ethnicity and culture in shaping the prevalence, symptom presentation, and treatment of eating disorders across diverse populations. Although eating disorders have traditionally been studied in Western, predominantly White populations, growing evidence suggests that cultural norms, ethnic identity, globalization, and exposure to Western ideals significantly influence both the development and expression of disordered eating behaviors. Twenty peer-reviewed studies published between 2000 and 2024 were included. These studies were identified through systematic searches of PubMed, Scopus, Web of Science, and PsycINFO and selected …

The Implementation Of The Therapeutic Alliance In Aphasia Rehabilitation Research: A Narrative Review, Shelby Swiercz

Honors Theses

Background: The therapeutic alliance (TA), defined as the collaborative relationship between clinician and client, is widely recognized as a key factor influencing rehabilitation outcomes. However, within aphasia rehabilitation, its role remains underexplored and inconsistently measured

Methods: This narrative review examined peer-reviewed studies published between 1990 and 2025 that focused on adult aphasia rehabilitation and addressed the client-clinician relationship. Studies were identified through database searches, including PubMed, CINAHL, ComDisDome, EBSCO, and Google Scholar, and analyzed using thematic analysis.

Results: Most of the studies employed qualitative methodologies, particularly thematic analysis and semi-structured interviews, to explore patient and clinician perspectives. The therapeutic alliance …

How Pollinator Populations Can Impact Chronic Disease Risk, Kylee Cubbison

Honors Projects

This project investigates how pollinator populations can impact chronic disease risk. Pollinator populations are declining, which can have serious implications for human health. Declining pollinator populations can limit healthy food production and affordability. Poor nutrition is a major risk factor for most chronic diseases. Less healthy food available for people to consume can negatively impact diets and increase the risk of developing chronic diseases. This project aims to address a potential gap in research existing on this specific topic regarding pollinator populations and human chronic disease risk. A brochure targeted towards educating the general public on this topic was created …

Identifying Delays Impacting Maternal And Perinatal Deaths Using A Facility-Based Death Audit Review System Integrated With Community Engagement: A Mixed Methods Study, Zahid Memon, Wardah Ahmed, Shah Muhammad, Sajid Soofi, Shanti Chouhan, Arjumad Rizvi, Paul Barach, Zulfiqar A. Bhutta

College of Population Health Faculty Papers

BACKGROUND: Pakistan's persistently high maternal (178 per 100 000 livebirths) and neonatal (41 per 1000 livebirths) mortality ratios are compounded by lack of reliable data on the root causes and preventable risk factors, which hinders their effective use in improving care and progress toward safe, high-quality services. We sought to identify system delays impacting maternal and perinatal deaths using a facility-based death audit review system integrated with community engagement for implementing actionable solutions.

METHODS: We used a mixed methods, concurrent parallel study design at three secondary level healthcare facilities in District Matiari, Sindh, Pakistan. We reviewed 319 cases that included …

Nurse Education On Nonpharmacological Management Of Knee Osteoarthritis, Toyin Mary Ajayi

Walden Dissertations and Doctoral Studies

The Doctor of Nursing Practice (DNP) project aims to fill the gaps in the management of knee osteoarthritis (OA) in adults aged 40 to 75 years in a primary care practice. Knee OA is a common chronic disease that significantly impacts pain, mobility, and quality of life. Although there is empirical evidence that nonpharmacological interventions, including exercise, weight control, and self-management education, are effective, these methods are not consistently used in clinical practice, and pharmacologic treatment continues to be used. The project was designed to inform healthcare personnel about evidence-based nonpharmacological strategies to improve patient outcomes and reduce reliance on …

Community-Based A1c Screening Initiative To Improve Diabetes Risk Identification Among People Experiencing Homelessness, Rebecca Drake, Deedee Long, Mariita Carter

Student Works

Abstract

Purpose: People experiencing homelessness (PEH) experience high rates of undiagnosed diabetes yet face significant barriers to preventive screening. This quality improvement project aimed to improve access to diabetes screening for PEH through on-site hemoglobin A1C (A1C) testing in a trusted community setting.

Methods: On-site A1C screening was implemented at the Utah County Food and Care Coalition (F&CC) using a low-barrier, community-based approach. Screening was conducted during routine service hours and integrated into existing workflows. Process, outcome, and balancing measures were used to evaluate feasibility, reach, and unintended effects.

Results: The intervention primarily supported identification of diabetes risk and referral …

Multifocal Papillary Thyroid Carcinoma With Ret P.V804m, Eml4-Alk Fusion, And Braf V600e Positivity, Jacob Beiriger, Leonard Estephan, Lubna Zuberi, Stacey Gargano, Elizabeth Cottrill

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Multifocal papillary thyroid cancer (PTC) can arise from independent primaries with discordant drivers in parallel clonal evolution rather than a single-clone pattern. We present a 31-year-old female with multifocal PTC harboring 3 distinct oncogenic alterations: a germline RET p.V804M mutation, low-frequency EML4-ALK fusion, and BRAF V600E mutation. The RET and ALK alterations were identified in a midpole nodule, whereas BRAF positivity was seen in a separate lower pole tumor. Ultrasound revealed multiple right-lobe thyroid nodules; the dominant 2.1-cm lesion was hypoechoic with calcifications. Fine needle aspiration revealed Bethesda III cytology, prompting thyroid lobectomy and an ipsilateral central neck dissection was …

Optimizing Costs & Efficiency With Heartcode Complete: A Quality Improvement Project, Jessica Bryant

Doctor of Nursing Practice Final Project Abstract

PURPOSE

This quality improvement project aimed to implement HeartCode Complete (HCC), a simulation-based BLS training platform, at a 154-bed community hospital. The goal was to replace instructor-led BLS training, improve training efficiency, reduce costs, increase certification compliance, and enhance staff satisfaction.

BACKGROUND

Maintaining competency in CPR is a regulatory requirement for healthcare providers. Traditional instructor-led BLS training requires scheduled classes, instructor availability, and staff time away from clinical duties, contributing to certification delays and operational inefficiencies. Simulation-based training platforms offer self-directed learning with real-time feedback.

METHODOLOGY

This quality improvement project used Lean Six Sigma principles and Plan-Do-Study-Act cycles to guide …

An Evidence-Based Approach To Boosting Recovery In Endurance Runners, Sayla F. Rios

Doctor of Nursing Practice Final Project Abstract

Purpose

The purpose of this quality improvement project was to implement evidence-based recovery strategies among endurance runners. The project aims to decrease injury prevalence, improve recovery behaviors, and reduce perceived muscle soreness.

Background

Running-related injuries are common among endurance runners and are often associated with inadequate recovery. Evidence suggests that the use of recovery strategies may support muscle repair and reduce injury risk.

Methodology

This project used the Plan–Do–Study–Act framework to guide the implementation of strategies. 24 endurance runners participated in the project. Interventions included education and the implementation of recovery strategies, such as adequate protein intake, sleep optimization, self-myofascial …

Speed Of Intravenous Fluid On Glycocalyx Integrity And Central Blood Volume In A Porcine Septic Shock Model, Yosef Levenbrown, Md Jobayer Hossain, Paul T. Fawcett, Marjorie Postell, Anne M. Hesek, Lynell S. Jones, James P. Keith, Thomas H. Shaffer

Department of Pediatrics Faculty Papers

BACKGROUND: It is unclear whether the rate of intravenous fluid (IVF) administration in sepsis influences glycocalyx breakdown. This study aimed to measure the effect of rapid versus slow fluid bolus in a septic pig model on the integrity of the glycocalyx by measuring the serum levels of heparan sulfate and syndecan-1, breakdown products of the glycocalyx. Because endothelial glycocalyx is composed of apical cell membrane-bound proteoglycans such as syndecan-1, covalently bound with long linear glycosaminoglycans such as heparan sulfate, shedding of these different glycocalyx components is closely related. Additionally, we measured central blood volume (blood volume in the heart and …

How Mindfulness And Yoga Practices Are Implemented In Occupational Therapy, Madeline Roberts

Honors Theses

The application of yoga and mindfulness-based interventions (MBIs) in occupational therapy (OT) and their effects on occupational, cognitive, emotional, and physical outcomes are examined in this literature review. Occupational therapy is a comprehensive, client-based field that helps people engage in everyday activities to improve overall well-being, health, and independence. In recent years, there has been an increased interest in using mindfulness-based interventions in occupational therapy, as they align with OT's focus on well-being and quality of life. A systematic literature search was conducted using PubMed, WMU Library Search, and ScienceDirect to identify peer-reviewed research on mindfulness-based interventions, yoga, and occupational …

Hospital-Acquired Pressure Injury Prevention Using A Care Bundle In A Neuroscience Intensive Care Unit, Sarah Dolick

Doctor of Nursing Practice Final Project Abstract

Purpose: The purpose of this quality improvement DNP project was to implement a preventative care bundle to reduce the number of hospital-acquired pressure injuries.Compliance with bundle elements was monitored through weekly bedside audits. HAPI data were collected for 12 weeks pre-intervention and 12 weeks post-intervention to evaluate outcomes. The project utilized Plan-Do-Study-Act (PDSA) cycles to refine implementation and address barriers in real time.

Background: The project was implemented in a 32-bed neuroscience intensive care unit in an academic center in the Texas Medical Center.

Results: After implementation of the care bundle, average HAPIs decreased from 4.6 per survey (pre-intervention) to …

Staff Education On Early Sepsis Recognition For Medical-Surgical Nurses In The Acute Care Setting, Nadine Nzenga Udom

Walden Dissertations and Doctoral Studies

In this staff education project, I targeted early sepsis recognition and response among medical-surgical nurses. The practice gap at the site was nurses’ limited knowledge of sepsis indicators and screening tools, which contributed to delayed escalation of care. The practice-focused question guiding the project was “Does educating medical-surgical nurses on early sepsis recognition and response improve knowledge of early sepsis recognition and response?” I applied the analysis, design, development, implementation, and evaluation (ADDIE) and Johns Hopkins Evidence-Based Practice (JHEBP) models to design a structured sepsis education program for nursing staff. I searched for peer-reviewed literature via databases accessed through the …

Mississippi Coastal Bacterial Community Response To Lowered Salinty, Jackson C. Sues

Honors Theses

Microbial communities are essential to the function of coastal ecosystems; however, few studies have examined their response to short-term reductions in salinity. This study used a microcosm approach to examine how decreased salinity over five days affected seawater bacterial community composition, diversity, and richness. Microcosms were assigned to three treatments: unmanipulated seawater (control) collected from the Mississippi coast, seawater amended with natural freshwater, and seawater amended with sterilized freshwater. Length of time bacteria spent in the microcosms was found to have the strongest effect on bacterial community composition, while salinity effects were weaker but still statistically significant. All treatments shifted …

Staff Education To Improve Knowledge Of Evidence-Based Engagement Strategies To Reduce No-Show Rates, Jerrica Luster

Walden Dissertations and Doctoral Studies

High no-show rates in outpatient mental health settings remain a persistent barrier to effective care delivery, negatively affecting continuity of care, patient outcomes, and access to services. In the identified practice setting, inconsistent use of evidence-based engagement strategies beyond standard reminder practices contributed to missed appointments. The purpose of this Doctor of Nursing Practice project was to evaluate whether a structured staff education intervention on evidence-based engagement strategies would improve staff knowledge as a foundation for enhancing appointment adherence. A quantitative pre- and posttest design was used to evaluate knowledge change following the intervention. Participants included outpatient mental health clinic …

Exploring Lived Experiences And Perceived Quality Of Life In Individuals With Parkinson’S Disease Engaging In Rock Steady Boxing: A Qualitative Study, Emma Norman

Capstone Projects

It is well established that exercise provides numerous benefits to the general population, including improved physical functioning, fall prevention, and better sleep (National Institute on Aging, 2025). For individuals living with Parkinson’s Disease, the benefits of exercise are especially meaningful as exercise plays a key role in managing symptoms. Regular exercise plays a critical role in managing both motor and non-motor symptoms of Parkinson’s Disease, contributing to improved quality of life and independence (Ellis & Rochester, 2018). A group fitness program for individuals with Parkinson’s Disease, called Rock Steady Boxing, has demonstrated positive quantitative outcomes, including improved balance, strength, and …

Development Of Purposeful Movement Breaks And Sensory Pathways To Enhance Student Engagement And Participation, Ashlyn Houck

Capstone Projects

Children in school settings frequently spend extended periods seated in classrooms, which can make it difficult to meet their sensory and movement needs throughout the school day. When these needs are unmet, students may demonstrate behaviors that disrupt learning and limit participation in classroom activities. This capstone project addressed the need for sensory and movement opportunities within the school environment. Objectives included establishing a baseline of teacher knowledge related to the sensory systems, implementing movement breaks within daily classroom routines, and introducing sensory opportunities in hallways to support smoother transitions. The project was implemented with second- and third-grade classrooms. Outcomes …

Promoting Maternal Well-Being: Occupational Therapy In Pregnancy And Postpartum, Nora Udrys

Capstone Projects

Navigating pregnancy and the postpartum period can be a complex experience for women. There is a lack of diverse information, accessible resources, and support during this phase of life. Hormonal levels fluctuate not only during pregnancy but after giving birth as well, contributing to significant physical, emotional, and cognitive changes. Some of these changes may create barriers to meaningful participation in daily occupations, contributing to feelings of isolation, mood disruptions, and decreased overall well-being. Occupational therapy has a unique role in supporting women through pregnancy and postpartum by helping them navigate these transitions through a holistic, client-centered lens. The purpose …

Sexuality And Intimacy: Education On Ot Approach, Abby Stritzinger

Capstone Projects

Providing proper education on sexuality and intimacy is important for increasing comfort when addressing sex and intimacy with individuals in the professional field.  “Sexual health requires a positive and respectful approach to sexuality and sexual relationships, as well as the possibility of having pleasurable and safe sexual experiences, free of coercion, discrimination and violence. For sexual health to be attained and maintained, the sexual rights of all persons must be respected, protected and fulfilled” (WHO, 2006a). Creating occupational therapists (OTs) that are comfortable addressing this topic is extremely important for the OT profession to continue to maintain its holistic, client-centered …

Expanding Nbcot® Exam Readiness Resources In An Entry-Level Otd Program, Thahiyatul Sarah

Capstone Projects

The National Board for Certification in Occupational Therapy (NBCOT®) exam is a critical requirement for entry-level occupational therapy (OT) practice in the United States; however, many students face challenges in effectively preparing for its clinical reasoning demands. This literature review examines existing research on NBCOT® exam preparation strategies to inform the development of a comprehensive exam content guide and resources tailored for OT graduate students. Existing barriers, including gaps in curriculum alignment, limited access to effective study tools, and high levels of student stress, highlight the need for more structured and accessible preparation methods. By examining key themes such as …

Expanding Access To Equine-Assisted Occupational Therapy: Integrating Clinical Application And Program Development, Deanna Rietveld

Capstone Projects

This capstone project explored the role of hippotherapy in occupational therapy through enhanced clinical practice skills as well as supporting program development through community education and funding accumulation for the capstone site organization. Guided by a needs assessment drawn from literature, site mentor input, and other local organizations providing similar services, it was determined that occupational therapy using equine movement provides more impactful results while simultaneously addressing deficits in a variety of areas, but lack of financial resources, community participation, and therapy scholarships threaten the opportunity to expand programs and provide access to individuals who would benefit from services. In …

Practical Exploration Of The Role Of Occupational Therapy In A Nature-Based School Setting, Emma Campbell

Capstone Projects

School-based occupational therapy (OT) plays a critical role in supporting children’s participation, development, and engagement in educational environments. However, non-traditional school settings often lack therapeutic supports, such as OT services. The purpose of this doctoral capstone experience (DCE) is to explore and expand the role of occupational therapy within a non-traditional academic setting, specifically a nature-based preschool program. Sunflower Farm’s preschool program provides a unique learning environment that supports children’s development through farm-based learning. While this setting offers rich opportunities for exploration and growth, additional supports are needed to facilitate students’ sensory processing, self-regulation, and participation.

The objectives of this …