Medicine and Health Sciences Commons^™

Synthesis Of Novel Tetrafluorinated Alcohols Through The Dimerization Of Difluoromethyl Ketones For Use In Drug Development, Abigail A. Ryan

Honors Theses

As the most electronegative element, fluorine has unique applications and properties. The carbon-fluorine bond is known to be one of the strongest bonds in organic chemistry. As a result of fluorine’s high C–F bond strength, fluorine chemistry has become an interdisciplinary field of chemistry, pharmacy, physics, geology, and ecology. In pharmaceuticals for example, current estimates indicate that about 15–20% of FDA approved small-molecule drugs include at least one fluorine atom. The incorporation of fluorine atoms into organic molecules has become a powerful strategy in modern drug development, as fluorination can enhance metabolic stability, lipophilicity, and biological activity. Despite these advantages, …

Celiac Plexus Radiosurgery For Retroperitoneal Pain In Advanced Cancer: A Pre-Specified Secondary Analysis Of Health-Related Quality Of Life In A Phase Ii Single-Arm Trial, Aisling Barry, Ronen Fluss, Laura Dawson, David Hausner, Michael Buckstein, Talia Golin, Laurence Freedman, Marcin Miszczyk, Dayssy Diazpardo, Artur Aguiar, Dror Limon, Raphael Pfeffer, Moaz Ben-Ayun, Liat Hammer, Ziv Symon, Ofir Morag, Gali Jacobson, Adam Dicker, Jerzy Wydmanski, Camilla Zimmermann, Yaacov Lawrence

Department of Radiation Oncology Faculty Papers

BACKGROUND: Retroperitoneal pain syndrome seen in pancreatic cancer is a major clinical challenge. Celiac plexus radiosurgery, a new palliative technique for retroperitoneal pain syndrome, decreased pain levels in a phase II study. Here Health-Related Quality of Life (HRQOL) outcomes are reported.

METHODS: Evaluable patients, who were enrolled between January 2018 and December 2021, in an international single-arm Phase II ethics-approved study (NCT03323489), were included. The pre-specified secondary endpoint-change in HRQOL from baseline to 3- and 6-weeks post-treatment, was measured by the Functional Assessment of Cancer Therapy - Hepatobiliary (FACT-Hep) version 4 questionnaire. Mean change was deemed clinically significant (CS) if …

Community Composition Of Antibiotic-Resistant Bacteria On The Mississippi Gulf Coast, Marisa Martin, Colin Jackson

Honors Theses

The Mississippi Gulf Coast is an important resource for transportation, economic development, and recreation. Given its economic and cultural importance, it is crucial to maintain clean and safe conditions along the coast for public health, but other than routine beach monitoring, few studies have examined microbial contamination of coastal waters in this region. This study aimed to determine the quantity, composition, and distribution of bacteria resistant to six different antibiotics (Vancomycin, Kanamycin, Tetracycline, Ciprofloxacin, Erythromycin, or Amoxicillin) in seawater at seven public beaches along the Mississippi Gulf Coast. No bacteria resistant to Ciprofloxacin were detected, and bacteria resistant to Kanamycin …

Lifestyle And Activity Patterns Of The Classic Period Maya From Chac Balam And San Juan, Ambergris Caye, Belize, Abigail L. Hornbeck

Honors Theses

Bioarchaeological research often uses skeletal remains to reconstruct patterns of activity and labor in past populations. This study examines potential sex-based differences in long bone morphology among individuals from the Classic Maya sites of Chac Balam and San Juan on Ambergris Caye, Belize. These coastal communities participated in maritime trade networks, and daily activities such as cargo transport, canoe travel, and fishing may have placed distinctive mechanical stresses on the skeleton. The goal of this study was to evaluate whether measurable differences in bone structure between males and females reflect differences in habitual activity patterns.

Two complementary methods were used …

Mapping Information Literary To The Medical Curriculum, Ella Hu, David Stewart

Posters

Medical school accreditation by the Liaison Committee on Medical Education (LCME) requires library staff to be responsive to educational needs. Despite a move toward integrated learning, library instruction is often limited to single sessions early in the curriculum. Curriculum mapping addresses this by providing a systematic analysis of program courses to visualize teaching priorities and the student experience. This strategic tool enables librarians to shift from reactive service to proactive engagement, finding high-impact courses through syllabus analysis. Furthermore, aligning the ACRL Framework with medical education standards, such as AAMC Core EPAs and ACGME requirements, is essential for identifying instructional gaps …

Not All Health Problems Are Medical, Lisa George, Jennifer Hartke, Linda Caurdy-Bess, Karen Glorio

Posters

Medical Legal Partnership (MLP) started in 1993 in Boston. Currently MLP’s have been established in over 450 health care institutions in 49 states. Patient Legal Support (PLS) began in August 2009 and is a collaborative effort between Corewell Health East (then Beaumont Health system) and Lakeshore Legal Aid. Modeled after Boston Medical Center’s Family Advocacy Program, PLS provides educational training to health care providers, helping them recognize legal issues that affect the health of their patients, refer patients with legal problems, and improve their own advocacy skills.

How Medical Education Reframes Perceptions Of Substance Use Disorder: A Study Of Evolving Student Attitudes, Eva Neueunschwander, Cameron Davidson

Posters

According to the Substance Abuse Mental Health Services Administration (SAMHSA), in 2022 about 50 million people had experienced a substance use disorder (SUD) in the past year.1 Despite the alarming prevalence of SUD, stigma remains a major barrier to seeking and obtaining high quality treatment. Understanding how medical students view SUD and how perceptions change across their educational journey is essential for improving patient care. While previous studies have investigated SUD stigma among medical students, the effect of study year on attitudes remains largely mixed and unclear.2 This project compares attitudes across educational levels to understand how medical training influences …

The Library As A Partner In Wellness: A Curated Resource Collection For Medical Students, David Stewart

Posters

Medical education involves intense stress; 82% of students experience high distress, facing higher rates of burnout and mental illness than the general population2,3. This is often attributed to a medical culture prioritizing technical efficiency over humanistic care1 . Medical libraries are uniquely positioned to bridge this gap, as students perceive them as safe, confidential communal spaces2 . Despite this, only 18% of U.S. medical libraries currently offer dedicated wellness resources2 . To address this, Narrative Medicine, the engagement with patient stories, has emerged as one way to foster narrative competence1 . These interventions improve clinical connections and self-perspective, helping students …

Reframing Inclusion Through Scholarship & Equity (Rise) Equity Project 2026, Tonya Bailey, Brandon Harris, Abhinav Krishnan, Trini Mathew, Amita Pai, Julie Zaituna, Tracey Taylor

Posters

The OUWB RISE program is a faculty development educational initiative, and this poster disseminates both clinical and foundation faculty scholars’ year-long, project-based learning focused on advancing inclusive and equitable medical education.

Short-Term Bayesian Influenza Forecasting In A Hospital Environment Using A Linear Kalman Filter., Shankar Kaleeswaran Mani, Grzegorz A Rempala, Eben Kenah, Fernanda L Schumacher

Ambulatory and Primary Care Articles

Accurately forecasting the weekly number of influenza (flu) lab tests and positive cases is important for hospitals as they work to plan staffing, manage supplies, and provide timely patient care. In this paper, we describe a practical use of a Bayesian Kalman filter to forecast weekly flu tests and positives in a hospital setting. Using data from a large hospital system in Ohio, we show that this approach, which blends real-time hospital information with historical patterns, offers a dependable way to anticipate flu-related patient volume as far as four weeks ahead.

Staff Education To Improve Appointment Adherence In Outpatient Behavioral Health, Yvonne Joseph

Walden Dissertations and Doctoral Studies

No abstract provided.

Genetic Analysis Of The X-Linked Adrenoleukodystrophy Gene Abcd1 In Drosophila Uncovers A Conserved Phenotype, Joshua Manor, Sharayu V Jangam, Hyung-Lok Chung, Pranjali Bhagwat, Jonathan C Andrews, Hillary Chester, Shu Kondo, Saurabh Srivastav, Juan Botas, Ann B Moser, Suzette M Huguenin, Michael F Wangler

Duncan NRI Faculty and Staff Publications

X-linked adrenoleukodystrophy (X-ALD) is a progressive neurodegenerative disorder caused by a loss-of-function (LOF) mutation in the ATP-binding cassette subfamily D member 1 (ABCD1) gene, leading to the accumulation of very long-chain fatty acids (VLCFAs). This disorder exhibits striking heterogeneity; some male patients develop an early childhood neuroinflammatory demyelination disorder, while other patients, including adult males and most affected female carriers, experience a chronic progressive myelopathy. Adrenocortical failure is observed in almost all male patients, with the age of onset varying, sometimes being the first diagnostic finding. The gene underlying this spectrum of disease encodes an ATP-binding cassette (ABC) transporter that …

Kern National Network At Ouwb: Helping Medical Student Ideas Come To Life While Promoting Student Wellness And Academic Success, Shivapriya Chandu, Ahmad Abu-Mahfouz, Rohit Ray, Riya Chhabra, Berkley Browne-Holtz

Posters

Poster Winner - Medical students experience evolving stressors and wellness needs throughout training. From preclinical coursework to board preparation and clinical rotations, priorities may shift over time. This project addresses the following research question: How can we effectively improve student wellness initiatives through student engagement during the M1- M3 medical school years?

The Cadaver As The First Patient: Early Integration Of Pathology In The Preclinical Anatomy Laboratory, Sruthi Shriram, Lauren Desantis, Tulika Singhal, Kevin Ta, Courtney Shields, Muhammad Jawwad Arshad, Varna Taranikanti, Madison Konja

Posters

No abstract provided.

Optimizing Patient-Facing Ai Chatbot Questions To Improve Readability And Actionability In Anesthesia Education, Sarah Kadado, Bianca Elias, Roy Soto

Posters

In anesthesia, high patient anxiety and limited counseling time increase the need for clear, usable information. Artificial intelligence (AI) chatbots (e.g., ChatGPT) are increasingly used for patient anesthesia education. Many AI-generated responses exceed the recommended 6th-8th grade reading level for patient education information. Responses also often lack actionable guidance for patients. This study quantifies how optimizing patient-facing prompts improves readability, understandability, and actionability.

Implementation Of Self-Directed Learning In Preclinical Respiratory Course, Tai Metzger, Kaycee L. Fillmore, Inaya Hajj-Hussein, Dwayne Baxa, Kyeorda Kemp, Virginia Uhley, Claudio Cortes

Posters

Self-directed learning (SDL) is essential to incorporate into the medical curriculum to develop lifelong learning skills. The Liaison Committee on Medical Education (LCME) defines four specific components of SDL that must be incorporated into medical education. We created an team-based SDL activity and evaluated whether this format aligned with the SDL components defined by the LCME, using students’ evaluations and reflections.

Perceptions Of Radiology Residency Staffing Models Across Years Of Training, Alex Zhang, Alexander Swantek, Adela Pouzar, Sayf Al-Katib

Posters

Case staffing is the primary method by which radiology residencies teach at the workstation. Despite this, the styles and methods for how staffing is performed have not yet been comprehensively described. Understanding these models and evaluating resident perspectives can inform best practices and enhance radiology education.

Do Preclinical Assessment Strategies Matter? Nbme Usage And Student Outcomes Across U.S. Medical Schools, Reem Fawaz, Aaryan Patel, David Thomas

Posters

Preclinical assessment strategies vary widely across U.S. medical schools. Limited data exist on how these strategies relate to student success outcomes. Our study examines whether exam usage patterns are associated with Step 1 performance, Step 2 performance, and overall match rate.

Equitable Exposure, Unequal Outcomes Summative Performance Following Clinical Integration Anatomy Laboratories, Christopher Ramus, Stefanie Attardi

Posters

Cadaver-based anatomy education remains essential but faces high content demands, limited physical and personnel resources, and a continually condensed timeline. These challenges necessitate efficient instructional efficient instructional strategies. Pedagogical research supports active learning strategies for better retention, engagement, and application.

Cellular And Molecular Basis Of Pfcoronin Function In Artemisinin Resistance In Plasmodium Falciparum, Imran Ullah, Eva S Istvan, Et Al.

2020-Current year OA Pubs

Artemisinin combination therapies are central to malaria control, but their efficacy is threatened by the emergence of resistant Plasmodium falciparum strains. While the role of Pfkelch13 mutations is well established, mutations in Pfcoronin have also been implicated in treatment failure, revealing layers of resistance complexity. Here, we define the cellular mechanism of Pfcoronin‑mediated artemisinin resistance. PfCoronin interacts with PfActin and localizes to the parasite plasma membrane, the digestive vacuole membrane, and small vesicles containing host cell material. Mutations in PfCoronin disrupt its localization and perturb PfActin homeostasis, altering the distribution of ring‑stage morphologies, including a reduced proportion of parasites adopting …

Mind Over Measure: The Role Of Self-Care Practices In Mitigating Mental Health Strain Among K-12 Educators, Jerry Burkett, Ryan Hulla

School Leadership Review

Teacher mental health is a critical concern in K-12 education, with high rates of burnout demanding effective protective strategies. This study investigated the relationship between five dimensions of teacher self-care (Physical, Psychological, Emotional, Spiritual, and Professional) and overall mental health outcomes, while specifically exploring differences between elementary (K-5) and high school (9-12) educators. A sample of K-12 teachers completed the Mental Health Inventory (MHI-5) and the Self-Care Inventory. Correlational analysis found that all five self-care dimensions were significantly and positively associated with mental health, with Professional Self-Care demonstrating the strongest link (r=.48, p

Screening Novel Secreted Proteins For Their Effects On Pancreatic Islet Function Using Qpcr-Based Gene Expression Analysis, Deepti Agarwal, Neha Mishra, Marcus Seldin

Cumberland Medica

Type 2 diabetes (T2D) involves progressive dysfunction of pancreatic β-cells and systemic insulin resistance. Although a handful of secreted factors acting on pancreatic islet have emerged as important therapeutic targets, many additional signaling processes remain unknown. The identification of such mediators can make a new contribution to the regulation of islet biology and serve as another approach for disease treatment. This study aimed to investigate whether three novel peptides could modulate islet-specific gene expression in vivo. Methods: Male C57BL/6J mice were injected with proteins then pancreatic tissues were collected six hours post-treatment. Total RNA was isolated, converted to cDNA, and …

Comparative Analysis Of Antegrade And Retrograde Nailing For Proximal, Shaft, And Distal Femur Fractures, Saahil Noupada

Rowan-Virtua Research Day

Background:

Antegrade and retrograde intramedullary nailing are widely used for femoral fractures, yet their relative advantages across fracture locations remain debated. This study compares union rates, time to union, malunion, and functional outcomes between approaches, stratified by AO/OTA classification.

Methods:

A systematic review of PubMed, Embase, Cochrane Library, Web of Science, and Scopus (2015 to 2025) was performed. Studies reporting outcomes of antegrade and/or retrograde nailing for proximal (31), diaphyseal (32), and distal (33) femoral fractures were included. Data on demographics, fracture classification, fixation method, and outcomes were extracted. Risk of bias was assessed using ROBINS-I. Pooled estimates were calculated …

Medical Providers’ Perspective On Barriers Faced By Intellectual And Developmental Disabled (Idd) Patients From Medically Underserved Backgrounds, Mayra A. Flores

Rowan-Virtua Research Day

•Complexities of obtaining healthcare access can be difficult for all patients across the board, so much so that it’s viewed as a maze. Studies have shown that these challenges are added on for medically underserved communities.2-3 Some of these challenges include insurance, language barriers, appointment availability, stigma, financial limitations and lack of transportation.2 •Identify the barriers that patients with intellectual and developmental disabilities (IDD) from medically underserved backgrounds face in healthcare access. •Intellectually and developmentally disabled patients from medically underserved communities face exacerbated barriers in healthcare access. •Participating medical providers from the Regional Integrated Special Needs Center (RISN) – Sewell …

Management Of Libman-Sacks Endocarditis: The Role Of Anticoagulation And Immunosuppressive Therapy, Klaudia Matanaj, Demi Poulathas, David Altimore

Rowan-Virtua Research Day

Background: Libman-Sacks endocarditis (LSE) is a nonbacterial thrombotic endocarditis detected in 10-40% of patients with systemic lupus erythematosus (SLE), depending on imaging modality. LSE is strongly associated with antiphospholipid syndrome (APS). The condition significantly increases the risk of cerebrovascular accidents and inpatient mortality compared to SLE without cardiac involvement. Despite these serious complications, optimal management remains uncertain. Objective: To review the current evidence on the pathophysiology and management of LSE. Methods: A literature review was conducted using 12 peer-reviewed articles addressing LSE pathophysiology, clinical outcomes, and treatment strategies. Results: Combination anti-inflammatory and antithrombotic therapy achieved 76% …

Age And Genotype-Dependent Baseline Characterization Of Spatial Learning And Memory In App/Ps1 Rats Using The Morris Water Maze, Thomas George, Mohammadreza Arbab, Nathanael Ricardo Alicea, Mahdie Kerdari, Christopher Janson

Rowan-Virtua Research Day

Background: Alzheimer’s disease (AD) is characterized by progressive cognitive decline. Transgenic APP/PS1 rat models offer improved translational relevance compared to mouse models due to closer similarity to human neurobiology.

Objective: To establish a baseline profile of spatial learning and memory across age and genotype in rate model.

Methods: The Morris Water Maze (MWM) was used to assess four groups of rats: young Wild Type (WT), young APP/PS1 (AD), middle-aged WT, and middle-aged AD. Spatial learning was evaluated during acquisition (Day 1–4) using cumulative proximity and escape latency. Memory was assessed using probe trials (Day 2–4). Swim velocity …

Involuntary Medication Administration Review: A Historical Look At New Jersey Psychiatric Law And Its Significance, Casey Burke, Joon Min Chun D.O., Ramya Kommidi D.O., Salvatore Montana Messina D.O.

Rowan-Virtua Research Day

The legal and ethical evolution of involuntary psychiatric medication in New Jersey has been shaped through the landmark legal cases Rennie v. Klein and Brandt v. Monte. To this effect, this poster explores how each case shaped state hospital policy and the balance between patient autonomy and clinical judgment. Rennie v. Klein (1978) established a constitutional right for involuntarily committed patients to refuse psychotropic medication, except in emergencies or with due process safeguards. Decades later, Brandt v. Monte (2006) exposed flaws in New Jersey’s administrative procedures—particularly Administrative Bulletin 78-3—which permitted coercive practices under the guise of emergency treatment and lacked …

Behind The Screen: The Effect Of Screen Time On The Pediatric Population, Arthi Rameshkumar, Tanvi Shah, Liam Courtney, Talia Hartman, Tanya Kadrmas-Iannuzzi

Rowan-Virtua Research Day

No abstract provided.

Tat-Beclin 1 And Exercise: Investigating Their Potential Synergy In Improving Sarcopenia-Related Muscle Changes In A Mouse Model, Shreya Krishnan, Thuan Thien Tchen, Kleiton Silva, Gabryel Sales Nascimento

Rowan-Virtua Research Day

No abstract provided.

Improving Adherence To Comprehensive Gynecological Assessments In Female Rectal Cancer Patients Prior To Rectal Cancer Treatment, Rachael Smith, Eleanor Williams, Emily Young

Rowan-Virtua Research Day

Background: A retrospective chart review of 139 female patients with Stage I-III rectal cancer treated at our institution (2017-2022) revealed only 32.6% (n=45) had documented age-appropriate gynecologic screenings prior to surgical intervention. These findings were disseminated to colorectal surgeons, medical oncologists, and radiation oncologists through departmental meetings and tumor boards. This follow-up study evaluates the impact of that educational initiative on gynecologic referral patterns. 

Hypothesis: Targeted education of colorectal surgeons, medical oncologists, and radiation oncologists would significantly increase gynecologic referral rates for female rectal cancer patients. 

Methods: This pre-post quality improvement study compared gynecologic referral rates among female patients with …