Medicine and Health Sciences Commons^™

The Treatment Of Diabetic Acidosis, Thaddeus S. Danowski

MCV/Q, Medical College of Virginia Quarterly

The patient with diabetes mellitus who becomes unconscious presents a problem in differential diagnosis. We now recognize six possible causes of coma in the diabetic patient. These include the usual diabetic keto-acidosis, and five possible non-ketotic causes: I. Keto-acidosis II. Non-ketotic causes of coma A. Unconsciousness unrelated to diabetes, e.g. barbiturate intoxication, "stroke," uremia B. Hypoglycemia C. Lactic acidosis D. Hypernatremia E. Hyperglycemia

The State Of Insulin In The Blood, Thaddeus E. Prout

MCV/Q, Medical College of Virginia Quarterly

Diabetes mellitus has been reviewed as a group of conditions with impaired function of one or more portions of a feed-back system involving the release and utilization of insulin. It is hoped that this may form a useful scheme by which we can study and understand a number of complex metabolic states which we must still collectively refer to as diabetes mellitus.

Insulin Antigenicity, Thaddeus E. Prout

MCV/Q, Medical College of Virginia Quarterly

Thus we have seen that evidence of insulin antigenicity in one or more forms is present in most individuals receiving intermediate insulins for six weeks or longer. A number of clinical manifestations of insulin antigenicity and their treatment have been discussed.

Insulin Antagonists, John A. Owen Jr.

MCV/Q, Medical College of Virginia Quarterly

In conclusion, the synalbumin antagonist exists, and may be important in the pathogenesis of human diabetes, but its role has not been proved. The proof will require elucidation of the problem of species specificity, and ability to measure accurately the levels of synalbumin antagonist.

The Pregnant Diabetic, William R. Jordan

MCV/Q, Medical College of Virginia Quarterly

At present, more diabetic females of childbearing age are going through pregnancy, and more diabetic children are living beyond maturity. The outlook for the pregnant diabetic has improved greatly but the infant mortality rate of diabetic children remains relatively high. My remarks are based on observations on 105 pregnant diabetics from my private practice.

The Contractile Fine Structure Of Vertebrate Smooth Muscle, Hans H. Weber, J. C. Rüegg

MCV/Q, Medical College of Virginia Quarterly

About 30 years ago, Ernst Fischer introduced a new approach to muscle research by comparing the fine structure, and the function of the contractile mechanism of smooth and striated muscle. At that time (Fischer, 1936a and b; 1938) he systematically and successfully investigated the total, the intrinsic, and the form birefringence of smooth muscles and compared his results with analogous data concerning the contractile structure (Noll and Weber, 1935) and the oriented actomyosin threads (Weber, 1935) of skeletal muscle. These investigations were especially important because the birefringence of all muscles is based on its contractile structure and functional state, and …

Latency Relaxation: A Brief Analytical Review, Alexander Sandow

MCV/Q, Medical College of Virginia Quarterly

In this report I review certain aspects of the research on the latency relaxation (LR), the minute relaxation of a stimulated muscle that occurs during the latter half of the latent period, i.e., just prior to the onset of contraction (e.g., Sandow, 1944). The first part of my discussion will be historical, dealing with the early, mostly descriptive work on the LR, and then I shall present a more analytically oriented attempt to indicate the significance of the LR in relation to certain aspects of the response of a muscle to stimulation.

Some Effects Of Extreme Shortening On Frog Skeletal Muscle, Sibyl F. Street, Michael N. Sheridan, Robert W. Ramsey

MCV/Q, Medical College of Virginia Quarterly

We have established that the sarcolemma of frog skeletal muscle is so firmly tied in at each sarcomere level near the M line, as well as near the Z line, that it is thrown into folds or festoons when the fibers shorten. The attachment is not broken even when the fibers shorten to 25% of optimum tension length. Such extreme shortening affects both the morphology and physiology of the muscle; the morphological change seems to be limited to the myofilaments. The physiological effects in frog sartorius muscle include an increase in resting oxygen consumption and changes in the relation between …

Cholinergic Responses Of Schistosoma Mansoni, Ernest Bueding

MCV/Q, Medical College of Virginia Quarterly

It is concluded that the use of pharmacological agents can provide opportunities to recognize and define similarities and differences in the mechanisms of transmission of nerve impulses in the parasite and the mammalian host. Such studies contribute to better understanding of comparative physiology and of the mode of action of antiparasitic drugs.

Comments On Intracellular Studies Of Presynaptic Inhibition, Alfred J. Szumski

MCV/Q, Medical College of Virginia Quarterly

The use of intracellular electrodes, e.g., (micropipettes), in electrophysiological studies of the central nervous system, has enhanced our understanding of the basic function of the nervous system. The purpose of this paper is to review a study in which this microtechnique was successfully employed in the spinal cord.

Recollections Of Professor Otto Meyerhof, Chalmers L. Gemmill

MCV/Q, Medical College of Virginia Quarterly

Professor Meyerhof's laboratory represented the Institute approach with all of the workers devoting their attention to the several aspects of the single problem of muscle metabolism. The number of papers (Meyerhof, 1930) and the great contributions from this laboratory represent the results of the dominant personality of one man. The tributes (Nachmansohn, 1950) paid to him in 1950 were published in Metabolism and Function. Comparable tributes are now being given to Dr. Fischer upon his retirement.

Clinicopathological Conference: Complications Of Rheumatoid Arthritis, P. Franklin Mullinax, R. Page Hudson Jr.

MCV/Q, Medical College of Virginia Quarterly

Clinicopathlogical conference transcript from the Medical College of Virginia. Discussants include P. Franklin Mullinax and R. Page Hudson.

The Patient Has The Floor, Alistair Cooke

MCV/Q, Medical College of Virginia Quarterly

Address given before the Annual Convocation of the Mayo Graduate School of Medicine, Rochester, Minnesota, on May 28, 1965.

Effects Of Salmonella Vaccination On Metabolism And Resistance To Infection Of Rabbit Peritoneal Cells, Marvin J. Allison, Enrique Gerszten, Blanca Sanchez

MCV/Q, Medical College of Virginia Quarterly

Salmonella vaccine caused a depression of metabolism of peritoneal exudate cells from rabbits. This effect was associated with a depression in resistance of rabbits to infection with C. albicans. This depression in metabolism is similar to the one previously noted following BCG vaccine and associated with a depression in resistance to tuberculosis.

Mcv/Q, Medical College Of Virginia Quarterly, Vol. 2 No. 4

MCV/Q, Medical College of Virginia Quarterly

No abstract provided.

Medical Manpower: The Medical Auxiliary, Harold I. Nemuth

MCV/Q, Medical College of Virginia Quarterly

Discussion based on The Assistant Medical Officer. The Training of the Medical Auxiliary in Developing Countries by E. F. Rosinski and F. J. Spencer. University of North Carolina Press. 1965. The current problem which Drs. Rosinski and Spencer have sharply delineated, is the provision of adequate medical care for all the people not only in the developing countries, but here in our so-called "well-developed" society. With or without Medicare the health needs of 190 million Americans increase daily with woefully disproportionate growth in the medical manpower needed to meet these needs. Whatever few failings may be attributed to the Assistant …

Volume Two Author Index

MCV/Q, Medical College of Virginia Quarterly

Author index for MCV/Q, Medical College of Virginia Quarterly, Volume Two.

Problems In The Insulin Dependent Diabetic, Clay T. Gardner Jr.

MCV/Q, Medical College of Virginia Quarterly

It is often useful for the physician to classify diabetes as stable or unstable. Maturity-onset diabetes is usually stable, and its management is not difficult, provided the patient is interested and cooperative. Tendency to obesity, relative insensitivity to insulin, and absence of ketosis are characteristic of such patients. Relative insensitivity to insulin does not imply unresponsiveness, but rather that the blood sugar is not overly labile and does not fall sharply in response to exercise or injected insulin. Many patients with such insensitivity to insulin are adequately managed on diet, alone or in combination with the oral hypoglycemic agents. When …

The Natural History Of Diabetic Retinopathy, Guy H. Chan

MCV/Q, Medical College of Virginia Quarterly

Diabetic retinopathy is a common and increasing cause of blindness. The higher incidence of retinopathy is related to the longer survival of the diabetic patient. The etiology of diabetic retinopathy remains unknown. However, two varieties appear to exist: Type I retinopathy, characterized by a slowly progressive course and ophthalmoscopic findings of microaneurysms, round hemorrhages, and waxy exudates; and Type II retinopathy, associated with a more rapid loss of vision, in which the main findings are venous engorgement, vascular proliferation, connective tissue condensation, and recurrent vitreous hemorrhages. Both types may result in retinitis proliferans and blindness. In the proliferative (Type II) …

Rate Of Diffusion Of Radioactive Ions In Gels, Thomas C. Smith, Addison D. Campbell, Ernst G. Huf

MCV/Q, Medical College of Virginia Quarterly

A simple gel-to-gel method is described for the estimation of diffusion coefficients (D) of radio-isotopic chemicals. "Cold" and "hot" gel cylinders, enclosed in small hypodermic syringes with their needle ends cut off, were carefully joined together, and diffusion was allowed to proceed for several hours. Slices of gels were then obtained for counting of activities. Application of the classical theory of diffusion permitted calculations of D values.

Inappropriate Antidiuresis: Examples Of An Hyponatremic Syndrome Resembling Exogenous Vasopressin Administration In Man, Eugene L. Klingler, Joseph H. Magee, John D. Bower, Richard H. Kirkland, Ruben G. Lancestremere

MCV/Q, Medical College of Virginia Quarterly

We have reviewed some of the features of hyponatremic syndromes, unassociated with sodium retention and edema, but associated with primary water retention. The syndromes were probably caused by excessive vasopressin activity, in the presence of normal circulatory, renal and adreno-cortical function. Underlying diseases, including bronchogenic carcinoma, head injury, and tuberculous meningitis, illustrated the diverse etiologic bases of this condition.

Mcv/Q, Medical College Of Virginia Quarterly, Vol. 2 No. 1

MCV/Q, Medical College of Virginia Quarterly

No abstract provided.

Contrangle - Vol. 7, No. 5, Dental Students Association

Contrangle

In this issue:

- Dean''s Honor Roll - A High Standard of Achievement

- Editorial

- DSA - - Jan. 13

- Loma Linda Sponsors Dental Student Research

- What, Me Specialize? Specialization in Periodontology

- Hygienist News

- Freshmen Hear Dean Sognnaes

- Alumni News . . .

- Space Fillers!

- S.S. White

Training Workout Log Book 1957-1966, Edward S. Temple

Temple Training Workout Log Books

No abstract provided.

Diabetic Neuropathy, Max Ellenberg

MCV/Q, Medical College of Virginia Quarterly

Diabetic neuropathy is becoming increasingly recognized because of its frequency and the severity of its manifestations. There is no domain in the field of medicine or surgery that is not at some time concerned with diabetic neuropathy. Neuropathy in diabetes may be divided into somatic and visceral types. I will discuss chiefly visceral neuropathy, but I should first say a few words about somatic neuropathy, which is the commoner of the two.

Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, Summer 1966, Volume Two, Number Two.

Self-Diffusion In Sodium Single Crystals, Rama M. Aiyawar, Addison D. Campbell

MCV/Q, Medical College of Virginia Quarterly

The objective of this investigation was the study of self-diffusion in single-crystal sodium using tracer techniques and the determination of the diffusion constant and activation energy. Precise values of these quantities can be obtained by using Fick's second law of diffusion and the relation D = D₀ exp (- Q/RT) provided the concentration of the diffusing isotope is kept very small. However, in the above relation, the quanties D₀ (diffusion constant) and Q (activation energy) may vary with the composition of the crystal and with impurity content but are independent of temperature.

Volume One Table Of Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, Volume One.

The Changing Pattern Of General Practice And Its Educational Implications, Frederick J. Spencer

MCV/Q, Medical College of Virginia Quarterly

The results of a mail questionnaire sent to members of the Virginia Academy of General Practice demonstrate the changes occurring in the content of family practice. Practitioners in small towns practice more obstetrics and less internal medicine than those in large cities, and conversely. The implications for training in general practice are discussed.

Some Surgical Problems In Diabetic Patients, David M. Hume

MCV/Q, Medical College of Virginia Quarterly

These patients illustrate some of the more perplexing and challenging surgical problems in diabetic patients. There are many others, but these are particularly gratifying because only a few years back the circulatory problems in the lower extremities were treatable only by high amputation, and in the case of kidney disease with renal failure, there was no other treatment at all.