Medicine and Health Sciences Commons^™

African Americans’ Perceptions And Experiences Of Aesthetic Environments As A Determinant Of Stress, Clarence Gardener

Walden Dissertations and Doctoral Studies

No abstract provided.

Promoting The Hpv Vaccine Across The League Of Arab States: A Scoping Review Of Interventions, Basil H. Aboul-Enein, Patricia J. Kelly, Fatmah Almoayad, Teresa Keller

College of Nursing Faculty Papers & Presentations

INTRODUCTION: This scoping review examined existing interventions designed to promote and educate about HPV vaccination in the league of Arab states (LAS).

METHODS: Following PRISMA-ScR guidelines and using a PICOS-informed approach, a comprehensive search was conducted across 16 databases to identify peer-reviewed intervention studies published between 2010 and August 2025.

RESULTS: Twenty-two studies met the inclusion criteria. Most interventions originated from Egypt and Saudi Arabia and were delivered in academic or clinical settings using short, didactic, one-group pre-post designs. Only a few studies incorporated behavioral theories, digital modalities, or multi-component strategies. Nearly all studies reported short-term improvements in HPV-related knowledge …

Temporary Blood Donor Deferrals: Analysing Their Impact On Donor Retention And Future Re-Donations, Ambreen Kashif, Rana Hasanato

Sultan Qaboos University Medical Journal

Objectives: Temporary blood donor deferral can be a challenge in retaining donors and to maintain a stable blood supply. This study aimed to analyse the pattern of temporary donor deferral and its impact on their future return for donation Methods: This retrospective study included deferred blood donors from the Blood Bank department of King Khaled University Hospital, Riyadh, Saudi Arabia, and included data from January 2021 till December 2023 with subsequent donors follow up till August 2025 were recorded .Effect of demographics, causes of temporary deferrals and gender wise distribution were compared between new and regular blood donors …

Role Of Staff Education In Improving Patient Medication Adherence To Reduce Crisis Recurrence Among Psychiatric Patients, Francine Wanjiku

Walden Dissertations and Doctoral Studies

No abstract provided.

Dnp Final Report: Enhancing Radiation Oncology Training For Advanced Practice Providers, Katherine A. Bukolt

DNP Final Reports

Background: Rising cancer incidence and improved survivorship are straining the oncology workforce, increasing reliance on Advanced Practice Providers (APPs). However, there is a lack of standardized educational resources for APP radiation oncology training across practice settings. Most APPs receive variable, resource-dependent, and on-the-job training. Evidence shows that the lack of standardized training leads to gaps in foundational knowledge, reduced confidence in toxicity management, inconsistent role development, and variable satisfaction with training and transition into practice.

Purpose: This quality improvement project evaluated the feasibility of implementing an 18-module Advanced Practice Radiation Oncology (APRO) asynchronous online curriculum to standardize APP radiation oncology …

Application Of Toast Criteria, Comorbidities And Outcomes In Patients With Ischemic Stroke: Multicenter Collaboration In The Dominican Republic, Ryna Then, Maria Muñoz, Cristina Ramos, Marcos Mota, Priscilla Sepulveda, Lisa José, Luis Suazo, Francisco Mendez, Yahaira Franco, Cosme González Villamán, Acela Gonell, Violiza Inoa, Gillian Gordon Perue, Manuel Colomé-Hidalgo, Nadja García

Einstein Health Papers

INTRODUCTION: Stroke is a leading cause of neurological-related death in the Caribbean. The Dominican Republic has among the highest stroke-related mortality rates in the Americas. We aimed to determine ischemic stroke etiologies, characterize comorbidities, and describe outcomes in the Dominican Republic using the TOAST (Trial of Org 10172 in Acute Stroke Treatment) classification.

METHODS: We analyzed a multicenter quality registry between January 2022 and October 2024. Statistical analyses included Mann–Whitney U and Kruskal–Wallis tests with Bonferroni correction, chi-square tests, and Spearman correlation.

RESULTS: The most common stroke subtype was undetermined etiology (54.8%), followed by large artery atherosclerosis (17.2%) and cardioembolism …

Association Of Cerebrovascular Center Volume With Patient Outcomes, Stacey Quintero Wolfe, Justin R. Mascitelli, Kyle Fargen, Peter Kan, Ketan Bulsara, Christopher P. Kellner, Brian M. Howard, Michael R. Levitt, Rocco Armonda, Joshua Osbun, Clemens Schirmer, Mark Bain, William J. Mack, Stavropoula Tjoumakaris, Adam Arthur

Department of Neurosurgery Faculty Papers

Current guidelines acknowledge the importance of both microsurgical and neuroendovascular expertise in the treatment of cerebrovascular disease. To achieve optimal care for these patients, it is becoming increasingly evident that procedural volumes impact patient outcomes. This is demonstrated across various cerebrovascular diseases.In this literature review, we demonstrate the association of volume with patient outcomes across multiple cerebrovascular disease states and interventions. Microsurgical aneurysm clipping remains essential even with the rise of endovascular therapy and mortality and patient-safety indicator events are clearly lower at high-volume centers for both ruptured and unruptured aneurysms. Likewise, patients undergoing surgery for cerebrovascular malformations and carotid …

Occupational Therapy’S Role And Impact In Cancer Prehabilitation: A Scoping Review, Abbey Rancour, Averi Haas, Emily Peckham, Kate Reimer, Kylie Mccaskill

Masters Projects

Background:

Oncology prehabilitation aims to optimize patients’ physical and psychosocial function before cancer treatment, yet the specific contributions of occupational therapy (OT) remain underexplored.

Objective:

This scoping review aims to map and synthesize the existing literature describing the role and reported benefits of OT within oncology prehabilitation programs.

Methodology:

Following Arksey and O’Malley’s (2005) scoping review framework and guided by the PRISMA-ScR checklist, three databases (PubMed, CINAHL, and Web of Science) were searched. Search terms included preoperative exercise, prehabilitation, neoplasms, and cancer. Articles were screened by two independent reviewers, and data were charted and analyzed descriptively and thematically.

Results:

A …

Kelelahan Kerja, Kualitas Tidur, Dan Pengetahuan Mengemudi Defensif Sebagai Faktor Risiko Perilaku Defensive Driving Pada Pengemudi Grabcar Malang, Elisa Lutfiyah Azizah, Dian Puspitaningtyas Laksana, Marji Marji, Agung Kurniawan

National Journal of Occupational Health and Safety

Online transportation activities contribute to the increasing volume of vehicles, particularly GrabCar drivers in Malang City, which has the potential to worsen traffic congestion. Identification results showed that GrabCar drivers experienced drowsiness while driving and work fatigue due to the habit of working at night and for more than eight hours per day, accompanied by limited understanding related to defensive driving. This study aimed to determine the effect of work fatigue and knowledge, as well as differences in sleep quality scores, on defensive driving behavior. This study employed an observational analytic design with a cross-sectional approach involving 87 GrabCar drivers …

Maternal Mental Health: What Utahns Need To Know, Brie Sparks, Susan R. Madsen

Marketing and Strategy Faculty Publications

Pregnancy and the transition to motherhood are often portrayed as joyful and fulfilling experiences, yet many women face significant emotional and psychological challenges. Maternal mental health conditions, including depression and anxiety, are among the most common complications of pregnancy and the postpartum period. Despite growing awareness, stigma, screening gaps, and limited access to care persist. In Utah, where rates are similar to or higher than national averages, expanding screening and resources will create a clearer path to better support mothers and families.

Forecasting Covid-19 New Cases Using Nbeats Deep Learning And Mobility Data, Amril Nazir, Mohammad Shorfuzzaman, Muhammad Lujaini Lotfi, Firuz Kamalov, Sufian Badawi, Maen Takruri, Abdul Halim Jallad

All Works

COVID-19 is a highly contagious disease transmitted primarily through human contact. Therefore, understanding population mobility is essential for predicting COVID-19 case trends. In this paper, we propose a novel deep learning approach for forecasting new COVID-19 cases using a neural architecture called Neural Basis Expansion Analysis for Interpretable Time Series (N-BEATS). The N-BEATS model effectively handles long input sequences and large output horizons without information loss or increased computational complexity. We compare the performance of N-BEATS with a state-of-the-art benchmark model, LSTM-Markov, across four major countries: the United States, the United Kingdom, Russia, and Brazil. Three distinct COVID-19 datasets from …

Cervical Insufficiency Revisited: A Proposal For A New Treatment-Aligned Definition, Vincenzo Berghella, Ilaria Paladino, Moti Gulersen, Rupsa Boelig, Amanda Roman

Department of Obstetrics and Gynecology Faculty Papers

Cervical insufficiency [CI] has traditionally been defined as painless cervical dilation resulting in recurrent second-trimester pregnancy loss in the absence of labor or placental pathology. Definitions from the American College of Obstetricians and Gynecologists and the Royal College of Obstetricians and Gynecologists emphasize historical clinical presentation. However, contemporary obstetrics relies increasingly on ultrasound-based cervical length surveillance and evidence-based cerclage indications rather than retrospective diagnosis. The objective of the review was to propose a definition of cervical insufficiency aligned with current evidence-based indications for mechanical prevention of preterm birth, i.e. cervical cerclage. In modern obstetric practice, the operational diagnosis of clinically …

Tusc3 Serves As A Rate-Limiting Gatekeeper Of A Glycan-Mediated Er Triage Checkpoint For Bmp4/Dpp, Antonio Galeone, Emilio Solazzo, Francesco Lavezzari, Seung Yeop Han, Gaia Consonni, Bruna My, Riccardo Rizzo, Giuseppe Gigli, Hamed Jafar-Nejad, Thomas Vaccari

Faculty, Staff and Students Publications

Trimming of the three glucose residues decorating nascent N-glycoproteins is a critical step for their entry into the endoplasmic reticulum quality control (ERQC) and recognition by ER chaperones. However, the functional relevance of the second glucose (G2) and the regulatory step upstream of its removal by glucosidase II (GCS2) remain poorly understood. Here, we report that TUSC3, a component of the oligosaccharyltransferase (OST) complex, regulates G2 to G1 trimming on N-glycosylated bone morphogenetic protein 4 (BMP4) and its Drosophila homolog Dpp to promote their ERQC entry. Loss- and gain-of-function genetic experiments and biochemical assays in mammalian cells and flies indicate …

Reply To: A Lethal Progressive Neuroinflammation Disguised As Mogad Revealing A Final Diagnosis Of Griscelli Syndrome: Regarding: Mogad Is The Most Common Cause Of Isolated Optic Neuritis In Children, Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Adeseye, Jonathan M Yarimi, Nikita Shukla, Timothy E Lotze, Kristen S Fisher, Alexander J Sandweiss

Faculty, Staff and Students Publications

No abstract provided.

Chemotherapeutic Induction Of Cytosolic Single-Stranded Dna Accumulation Sensitizes Triple-Negative Breast Cancer To Immunotherapy, Yong Du, Li Yang, Hui Dai, Jianli Zhou, Zhicheng Zhou, Ruoxi Yuan, Rui Ye, Anh Thai Quynh Nguyen, Kishor Bhatia, Shiaw-Yih Lin

Faculty, Staff and Students Publications

Background: Despite the widespread adoption of chemoimmunotherapy in triple-negative breast cancer (TNBC), the mechanisms by which cytotoxic chemotherapy engages antitumor immunity remain poorly defined. Identifying tumor-intrinsic immunogenic programs that predict and enhance responsiveness to immune checkpoint blockade (ICB) is therefore of critical clinical importance.

Methods: Transcriptomic signatures of TREX1 deficiency were generated from CRISPR-engineered TNBC models and applied to multiple independent TNBC cohorts treated with chemoimmunotherapy. Cytosolic single-stranded DNA (ssDNA) accumulation was quantified using a flow cytometry-based assay to functionally screen chemotherapeutic agents. Immune activation and therapeutic efficacy were evaluated using in vitro assays, syngeneic mouse tumor models, flow cytometry, …

Unveiling Unwritten Curricula: Enhancing Junior Faculty Development In Academic Emergency Medicine, Abagayle Bierowski, Casey Morrone, Erin Hoag, Ridhima Ghei, Michael Pasirstein, Julie Blaszczak, Dimitrios Papanagnou

Department of Emergency Medicine Faculty Papers

INTRODUCTION: The transition from resident to junior faculty in academic emergency medicine (EM) may be shaped not only by formal training and institutional policies but also by the "unwritten curriculum," a set of norms and expectations embedded in institutional culture. However, the unwritten curriculum and its potential to impact junior faculty development remains largely unexplored. Little is known about how junior faculty perceive, experience, and navigate these informal expectations, or the formal and informal structures that influence this process. In this study we aimed to explore junior faculty members' experiences with the unwritten curriculum in academic EM, with a focus …

Letter To The Editor: Hemodynamic Role In Hepatic Encephalopathy Pathogenesis Following Transjugular Intrahepatic Portosystemic Shunt Placement, John Halphen, Yash S Dayal, Cameron Laurie, Mohadese Ahmadzade, David Wynne, Mohammad Ghasemi-Rad

Faculty, Staff and Students Publications

Hepatic encephalopathy (HE) is a common complication following transjugular intrahepatic portosystemic shunt (TIPS) placement and is thought to result from reduced hepatic detoxification of neurotoxins. However, Zhuang et al in the World Journal of Radiology demonstrate that this understanding may be incomplete through exploration of the pathophysiology from a hemodynamic perspective. They found significant changes in cerebral blood flow (CBF) and spontaneous brain activity following TIPS. Initially, CBF increased in specific areas within the first month, followed by a return to baseline at three months. These CBF changes coincided with increased spontaneous brain activity that persisted in some areas, suggesting …

Two Decades Of Progress In The Prevention And Treatment Of Colorectal Cancer: From Aspirin To Targeted Therapy, Lovyanne Vergel De Dios, Salique Hassan Shaham, Puneet Vij, Manish Kumar Tripathi

School of Medicine Publications

No abstract provided.

Pharmaceutical Industry Manufacturing Trend For Tablet Dosage Forms And Opportunities For The Future: A Case Study Of Current Practice And Future Developments, Tarang Patel

Discovery Day

INTRODUCTION: Tablet dosage forms remain the most widely utilized oral drug delivery system due to their stability, ease of administration, cost-effectiveness, and scalability. Over recent decades, advancements such as high-speed compression, improved granulation techniques, and regulatory frameworks (bioavailability, validation, and quality assurance) have significantly shaped modern pharmaceutical manufacturing. However, current systems remain largely semi-automated and resource-intensive, highlighting the need for technological transformation.

METHOD: This study presents a case-based evaluation of a contemporary pharmaceutical tablet manufacturing facility. The analysis maps the complete production workflow, including material handling, dispensing, granulation, lubrication, compression, coating, inspection, and packaging. Operational practices were reviewed alongside quality …

Review Of: A Fragile Heritage: Untangling The Strands Of Faith And Mutation—Sheryl Leinbach, Beth Bennett, Karen Conley

Journal of Amish and Plain Anabaptist Studies

Get ready for an emotional roller coaster with parallel intellectual stimulation while reading Sheryl Leinbach’s A Fragile Heritage. Sheryl authentically describes the span of emotions and challenges faced by the mother of a child with Maple Syrup Urine Disease (MSUD), from birth through successful liver transplant. The book invites the reader to accompany the author on a journey of growing faith, intellectual expansion, and societal reflection as the family navigates through the turbulence of loving a notably broken child in a fallen world. [First paragraph.]

Workplace Environmental Exposures And Related Health Conditions Among Amish & Mennonite Women In Ohio, Lora Wyss, Ratchneewan Ross, Rosanna Hess

Journal of Amish and Plain Anabaptist Studies

Background: Although it is known that some plain (Amish and conservative Mennonite) women work in furniture finishing shops, commercial greenhouses, and on family farms, little is known about their exposure to harmful conditions and substances in those work environments and the incidence of any related illnesses. Aim: To assess the relationship between the exposure to potentially harmful environmental conditions and general health conditions, work-related illnesses, and work-related injuries, comparing adult plain women with adult women of the general population. Methods: Data in this exploratory, concurrent, mixed methods study were collected using a 24-item survey and semi-structured interviews. Descriptive and correlational …

The Impact Of Psychosocial Factors On The Recovery Of Upper Extremity Injuries And Trauma: A Systematic Review, Meghan Hall, Abigail Morgan, Annie Knight, Tanner Fletcher, Allison G. Freeman, Sharon M. Cosper

Journal of Applied Disciplines

This systematic review specifically addresses the question of identifying what psychosocial factors for individuals with upper extremity conditions impact recovery. Twenty two studies were examined with four themes arising: coping limitations, anxiety/stress, depression, and kinesophobia/pain. While extensive research exists to support the presence of an impact of psychosocial factors in upper extremity rehabilitation, further research should be done to expand on these findings to include how psychosocial factors effect rehabilitation of individuals with upper extremity conditions, and application of how these relate to the field of occupational therapy and quality of life.

Exploring Psychological Traits And Feedback Strategies In Physical Therapy Providers Learning Acceptance And Commitment Therapy, Dustin Cox

Journal of Applied Disciplines

Providing treatment interventions to clients with chronic pain is a complex task for any professional. Research suggests that clients with chronic pain experience declines in physical, emotional, and psychological quality of life. Client’s that have chronic pain have complex effects from dealing with this condition in their lives. Clients with chronic pain (i.e., pain lasting > three months) process pain through the emotional and reward circuitry in the brain which is different than client with acute pain. The literature base provides evidence that clients with chronic pain who receive psychologically based interventions along with physical rehabilitation have better outcomes than individuals …

Self-Management For Youth And Young Adults With Childhood-Onset Chronic Conditions: A Scoping Review Of Health Care Transition Planning Literature, Jennifer Emilie Mannino Ph.D., R.N., Cne, Cara C. Young, Monique M. Ridosh, Kristin Cleverley, Lin Li, Lynn Kysh, Catherine A. Harwood, Brooke Allemang, Linda Tirabassi-Mathis, Sharon Hudson, Stephanie M. Key, Benjamin C. Schwartzman, Jihye Lee, Manu Raam, Cecily L. Betz

Nursing: Faculty Publications

Objective: To determine the extent to which self-management has been investigated and reported in literature focused on the transition from pediatric to adult healthcare for youth and young adults with childhood-onset chronic conditions (CCCs).

Introduction: An estimated 1.2 million youth with CCCs are expected to enter adulthood annually in the United States. As these youth transition from pediatric to adult health systems, they are at risk for experiencing critical gaps in care continuity and adverse health outcomes. Health care transition models have emerged to address these gaps, with self-management recognized as a critical component of successful transition.

Inclusion criteria: The …

Long-Term Functional Synaptic Integration Of Genome-Edited Retinal Organoids In A Primate Model Of Macular Degeneration, Atsuta Ozaki, Akihiro Kawai, Ryutaro Akiba, Satoko Okayama, Nobuhiko Ohno, Keisuke Kajita, Tomohiro Masuda, Satoshi Yokota, Shin-Ichiro Ito, Du Peiyan, Kenta Onoue, Shigenobu Yonemura, Mineo Kondo, Yasuo Kurimoto, Yingbin Fu, Michiko Mandai

Faculty, Staff and Students Publications

Retinal organoids represent a promising regenerative strategy for restoring vision in retinal degenerative diseases, but the capacity of host cone bipolar cells in the primate macula to rewire with transplanted photoreceptors has not been established. In this study, we transplanted genome-edited ISL1-/- human retinal organoids lacking ON-bipolar cells into an acute laser-induced macular photoreceptor ablation non-human primate model. Using immunohistochemistry, ultrastructural imaging, and focal macular electroretinography, we demonstrate that host rod and cone bipolar cells actively extend dendrites toward grafted photoreceptors and form synaptic contacts, with evidence of functional signal transmission in a subset of transplanted eyes. Longitudinal, per-eye analyses …

Patent Ductus Arteriosus Spasm During Percutaneous Device Occlusion In Infants And Children, Hani M. Adel, Ashraf K. Mahmoud

Journal of the Saudi Heart Association

Background: Spasm of ductus arteriosus is an uncommon but significant phenomenon associated with transcatheter patent ductus arteriosus (PDA) occlusion. It can lead to procedural failure, improper device sizing, or even embolization of the occluder device as the spasm subsides post-procedure. Aim of this study is to report the frequency, features, management and outcome of PDA spasm during device closure in a single Egyptian center.

Patients and methods: Over about 3 years, 200 infants and children underwent percutaneous device occlusion. The echocardiographic and catheterization data of patients who developed spasm of PDA before or during or shortly after anesthesia …

Enhancing Research Communication With Visual Tools, Sonya Fogg

Library Class: Lunch & Learn

Understand the role of visual communication in medical research. Distinguish between data visualizations, infographics, and visual abstracts. Identify best practices and some resources and tools for creating effective visuals.

Teachers’ Awareness Of Family Engagement In Multilingual Education, Sedighe Zamani Roodsari

Journal of Multicultural Affairs

This study investigated public school teachers’ awareness of family engagement as a linguistic and cultural resource for multilingual students. Multilinguals are typically described as individuals who can communicate in more than one language, with English not being their native language, and their linguistic choices are influenced by societal norms and systems (Šifrar Kalan et al., 2024; Wei, 2008). Preparing pre-service teachers to enhance opportunities for multilingual students remains a critical need in teacher education programs, as they strive to move beyond monolingual ideologies in their teaching practices (Cárdenas Curiel et al., 2024; Kim & Choi, 2020; Williams & Ewing, 2019). …

Surviving Sepsis 2026: Key Updates, Amanda Rawa, Katherine Ghattas

Transformative Medicine

The 2026 update to the Surviving Sepsis Campaign guidelines introduces several important changes in the management of sepsis and septic shock, with a greater focus on tailoring treatment to individual patients. Notable updates include lower blood pressure targets for older adults with septic shock, continued support for early fluid resuscitation, the selective use of rapid diagnostic testing to guide antibiotic therapy, and increased flexibility in vasopressor selection for patients with cardiac dysfunction. These recommendations are based on emerging evidence aimed at improving patient outcomes while reducing unnecessary interventions and treatment-related complications. Overall, the updated guidelines reinforce a more personalized approach …

Mimickers Of Atrial Fibrillation: When All Irregular Rhythms Are Not Atrial Fibrillation, Tirumala Nischal Jasty, Devi Parvathy Jyothi Ramachandran Nair

Transformative Medicine

Atrial fibrillation (AFib) is the most common sustained cardiac arrhythmia and carries important therapeutic implications, particularly regarding anticoagulation and stroke prevention. However, AFib remains frequently misdiagnosed, often due to overreliance on automated electrocardiogram (ECG) interpretations and failure to recognize alternative causes of rhythm irregularity. This review highlights the fundamental ECG characteristics required for the diagnosis of AFib and emphasizes that not all irregular rhythms represent atrial fibrillation. Through a representative clinical case and discussion of common mimickers—including Mobitz I (Wenckebach) atrioventricular block, premature atrial contractions, blocked premature atrial contractions, multifocal atrial tachycardia, and sinus arrhythmia—we demonstrate key electrocardiographic features that …