Medicine and Health Sciences Commons^™

Personalizable Metabolic Models To Enable Immune Characterization And Drug Discovery, Joshua Loecker

Department of Biochemistry: Dissertations, Theses, and Student Research

Cellular metabolism is reshaped by disease and physiological state, and genome-scale metabolic networks (GSMNs) offer a systematic way to interrogate this biology and identify therapeutic targets. Building a GSMN from expression data, however, requires a sequence of stages including read processing, normalization and gene-activity classification, multi-omic integration, model reconstruction, simulation, and biological interpretation. These are typically handled by disconnected tools spanning multiple programming languages, file formats, and databases. The resulting reliance on heterogeneous interfaces and manual steps threatens reproducibility. This work develops an ecosystem of computational tools that carry an analysis from raw sequencing reads to mechanistic biological interpretation. First, …

Therapy With Empathy

DePaul Magazine

DePaul's Speech Language Pathology and Occupational Therapy graduate programs, newly aligned in the Department of Rehabilitative Sciences and Professions at the College of Science and Health, employ a community assets-based approach to serving diverse populations and individuals' needs across the lifespan.

Characteristics Of Intensive Care Unit Registries - Findings From The Global Registry Icu Datasets (Grid) Survey, Luigi Pisani, Paola Lecce, Cornelius Sendagire, Vrindha Pari, Carlo Olivieri, Rabiul Uddin, Diptesh Aryal, Priyantha Athapattu, Sean Bagshaw, Wangari Siika

Anaesthesiology, East Africa

Background: Intensive care unit registries, which aim to improve the quality of intensive care unit care through benchmarking and quality improvement initiatives, are active worldwide, with considerable dishomogeneity. We aimed to map core datasets, additional variables, and research activities of these registries.

Methods: A cross-sectional survey was disseminated to registry leads between October 2023 and June 2024. The survey was structured into four main topics: registry characteristics and coverage, core dataset features, additional modules, and registry-enabled research.

Results: Leads of 34/42 national registries responded (response rate 81%), covering 3,337 intensive care units, with a larger representation from …

Patient Factors Influencing Caregiver Burden After Stroke, Madison Johnson, Catherine Vaughn, Elizabeth Byrd

Expo Student Presentations

2026 Summer Expo Poster Presentation

• Health Sciences & Health Professions

Machine Learning Identifies Structural Predictors And Residual Hotspots Of County-Level Cardiovascular Mortality In The United States, Jeevan Nammi

Expo Student Presentations

2026 Summer Expo Oral Presentation

• Health Sciences & Health Professions

Comparative Hepatobiliary Adverse Event Reporting Phenotypes Among Traditional And Emerging Masld Therapies: A Faers Analysis, Jeevan Nammi

Expo Student Presentations

2026 Summer Expo Oral Presentation

• Health Sciences & Health Professions

Donor-Derived Cell-Free Dna As A Prognostic Biomarker After Heart Transplantation: The Define-Ht Study, Palak Shah, Paul J. Kim, Kelly H. Schlendorf, David A. Baran, Monica M. Colvin, Adam D. Devore, Howard Eisen, Kambiz Ghafourian, Michael M. Givertz, Eileen Hsich, Jaime L. W. Kennedy, Evan P. Kransdorf, Jose N. Nativi-Nicolau, Jignesh Patel, Eleni Tseliou, Omar Wever-Pinzon, Andrew Doud, Michelle S. Bloom, Sandra A. Carey, Navchetan Kaur, D Giovanni Biagini, Kyle E. Marshall, Michael Olympios, Mandeep R. Mehra, Josef Stehlik

Department of Medicine Faculty Papers

BACKGROUND: Measurement of donor-derived cell-free DNA fraction (dd-cfDNA%) and donor quantity score (DQS) is a noninvasive biomarker of acute rejection in heart transplantation (HT). Its prognostic value beyond histopathology remains uncertain.

OBJECTIVES: This study sought to evaluate associations between donor-derived cell-free DNA (dd-cfDNA) and clinically meaningful outcomes using a composite endpoint of treated rejection, graft dysfunction, retransplantation, or death within 1 year post-HT.

METHODS: The DEFINE-HT (Development of Noninvasive Cell-free DNA to Supplant Invasive Biopsy in Heart Transplantation) was a prospective, observational study following adult HT recipients at 10 U.S. centers for 1-year post-HT; blood was collected for dd-cfDNA testing …

Fluoroquinolone Use And Risk Of Pneumothorax In Adults Hospitalized With Community Acquired Pneumonia: A Retrospective Cohort Study, Steven Yi B. S., Saurav Sumughan B.S., Jessica Cobb M. D., Erika J. Yoo

Department of Medicine Faculty Papers

Objectives: The objective of this study is to examine the relationship between fluoroquinolone exposure and pneumothorax risk in patients hospitalized with pneumonia.

Methods: This retrospective cohort study used the TriNetX US Collaborative Network. We defined two mutually exclusive cohorts of hospitalized adults based on exposure to antibiotic classes commonly used to treat community acquired pneumonia: fluoroquinolone (ciprofloxacin, moxifloxacin, levofloxacin, and ofloxacin) versus nonfluoroquinolone (amoxicillin, azithromycin, ceftriaxone, and doxycycline). Patients with connective tissue disorders were excluded. The primary outcome was the occurrence of pneumothorax within 60 days. We used Cox proportional hazards regression to estimate hazard ratios (HRs) adjusted for demographics, …

Improving Iv Access Outcomes In Obstetric Care Through A-Diva Scale Utilization And Point-Of-Care Ultrasound, Parth S. Patel, Matthew T. Komorowski

Doctor of Nurse Anesthesia Practice (DNAP) Manuscripts

Obstetric (OB) patients frequently present physiological changes, including edema, obesity, and peripheral vasoconstriction, that increase the risk of difficult intravenous access (DIVA). Multiple IV attempts can delay time-sensitive therapies in obstetric emergencies and increase patient discomfort and provider workload. Research studies have supported the use of the Modified Adult Difficult Intravenous Access (A-DIVA) scale to assess patients for DIVA, and the use of point-of-care ultrasound (POCUS) guided peripheral intravenous access (PIVA). In 2025, a preceding Doctor of Nurse Anesthesia Practice (DNAP) project implemented A-DIVA in the Labor & Delivery (L&D) unit of an OB department and found that 35% of …

Empowering Domestic Violence Survivors Through Community-Based Self-Regulation Suppor, Xen Gabrielle O. Advincula

Occupational Therapy Student Capstones

Purpose: Program development of trauma-informed, occupation-based resources and program and incorporating OT-related principles to support occupational balance and engagement of survivors of DV and IPV

Goal: Enhance and support the staff’s capacity and understanding of OT-scope in community settings and incorporation of OT-focused self-regulation strategies

Outcome: Increase the staff’s confidence levels of knowledge on the scope of OT within community-based settings and OT-related strategies to support self-regulation levels

An Epilepsy Community Collective Towards Occupational Justice And Empowerment, Tyler Debuty

Occupational Therapy Student Capstones

Underutilization of epilepsy-specific resource programs, lack of public awareness about epilepsy, limitations in community belonging, and implications for self-management programs aimed towards improving quality of life and reducing the burden of care during the transition into adulthood and throughout the lifespan for people with epilepsy.

Improving Quality Of Life For Informal Caregivers Of Post-Stroke Survivors: Implementing Preventative, Advocacy And Educational Strategies, Joann Bennett

Occupational Therapy Student Capstones

Stroke recovery extends beyond hospital discharge, yet community-dwelling stroke survivors and their informal caregivers often have limited access to continued education, wellness resources, and community-based support.

This gap contributes to caregiver burden, reduced occupational participation, and decreased quality of life.

Amplifying Parental Well-Being: Ot-Informed Support For Families Of Children With Hearing Loss, Joelle Barth

Occupational Therapy Student Capstones

Despite the many demands placed on parents of children diagnosed DHH, limited support exists to specifically address their mental health needs

Bridging Gaps In Spanish-Speaking Individuals In Rural Areas About Parkinson’S Disease, Fabiola Barajas Velasco

Occupational Therapy Student Capstones

Provide education and bring awareness of Parkinson’s disease in rural areas through educational trainings and community outreach, specifically those close in contact with farmworkers or farmworkers themselves.

Occupational Therapy Approaches To Mitigating Cancer-Related Fatigue (Crf): A Scoping Review And Practice Framework, Brooke Carson

Occupational Therapy Student Capstones

Goal: Improve knowledge and competence in CRF management through evidence-based education to improve CRF interventions in oncology rehabilitation

Outcome: Increased confident and application of evidence based CRF intervention strategies, leading to improved functional performance and occupational engagement for individuals experiencing CRF

Promoting Mental Health Awareness, Advocacy, And Occupational Justice For First-Generation College Students, Gilberto Duran Garcia

Occupational Therapy Student Capstones

First Generation College Students (FGCS) face a high prevalence of mental health concerns

Stress, anxiety, depression, financial burden, cultural expectations, imposter syndrome, pressure to meet expectations, fear of the unknown, lack of guidance, and lack of preparedness

Enhancing New Mother's Mental Health And Confidence After Discharge, Breana De La Cruz

Occupational Therapy Student Capstones

New mothers lack guidance, education and resources for common postpartum complications resulting in a decreased overall wellbeing in the postpartum period.

Exploring The Role Of Functional Cognition In Early Psychosis Care: An Occupational Therapy Perspective, Angelica Detata

Occupational Therapy Student Capstones

Cognitive impairment is a core feature of psychosis significantly impacting functional outcomes. Functional cognition as a target in early psychosis treatment is insufficiently addressed.

Fostering Wellness: Developing Strategies To Improve Mental Health And Decrease Burnout For Professionals Serving Foster Youth, Amaya Dorado Ledesma

Occupational Therapy Student Capstones

High burnout rates, turnover, and decreased mental health are limiting not only foster youth professionals, but also the families and children they serve.

Going With The Flow: Psychological Flow & The Mental Health Of Occupational Therapy Students, Sydney Buchanan

Occupational Therapy Student Capstones

Despite a growing interest in psychological flow as a factor associated with positive mental health outcomes, its relationship to OTD student well-being has remained underexplored.

Post-Stroke Fatigue: Bridging Neuropathology And Neurorehabilitation-Translating Research Into Clinical Assessment And Intervention Strategies, Wesley Green

Occupational Therapy Student Capstones

Current clinical approaches to post-stroke fatigue are challenged by limited evidence and an incomplete understanding of its underlying mechanisms.

Healing After Loss: Maternal Wellness Following Perinatal Loss, Farah S. Hakim

Occupational Therapy Student Capstones

Perinatal loss can disrupt women's roles, routines, identity, and emotional well-being.

Postpartum services often focus on medical recovery within healthcare settings.

Limited occupational therapy and culturally responsive resources exist after perinatal loss

Neurodivergent Well-Being In Independent Living Skills Programs: Impact Of Ot-Informed Resources And Community Programming, Grace Hepner

Occupational Therapy Student Capstones

There is a need for multidimensional support for neurodivergent college students due to an increasing number of these students enrolling in higher education.

Kickin' It Old School: Connecting The Ages, Elyssia Lambert

Occupational Therapy Student Capstones

Problem Statement

Lack of social participation is associated with negative impacts on QoL in individuals with dementia

Lack of awareness and knowledge of OT as a career option

Connection For All: Supporting Neurodivergent-Accessible Sex And Dating Education, Emma Martinho

Occupational Therapy Student Capstones

While engaging in sexuality and dating are expressed interests for neurodivergent young adults, there is a lack of support limiting their participation.

Supporting The Transition: A Summer Camp Model For Students With Adhd Entering Middle School, Anna G. Schene

Occupational Therapy Student Capstones

Students transitioning from elementary school to middle school experience newfound independence, requiring sufficiency in their executive functioning skills. The school-based OT service delivery does not always include or target this population, leaving students without the support needed to develop these skills.

Unequal Access, Unmet Needs: Rethinking Occupational Therapy In Private Practice, Meghan Smith

Occupational Therapy Student Capstones

Individuals from low-SES backgrounds often experience barriers to occupational therapy services, while private practitioners face challenges balancing accessibility with financial sustainability. These challenges underscore the need to better prepare future occupational therapists to provide equitable, accessible, and sustainable services within private practice.

Learn As You Are: Equipping Key Educational Stakeholders With Neuro-Affirming Knowledge To Support Inclusion Of Autistic Students, Jessalyn Sulamo

Occupational Therapy Student Capstones

Students throughout the autism spectrum often experience challenges relating to social and communication difficulties, sensory challenges, and inflexible approaches that hinder their social, emotional, and academic well-being (Black et al., 2024).

Clinician Perspective And Uses Of Technology In Neurological Home Health Rehabilitation: A Quality Improvement Project, Sean Sullinger

Occupational Therapy Student Capstones

Despite advancements in technology-based intervention systems and supporting evidence on its benefits, rehabilitation clinicians often demonstrate minimal adoption rates in practice due to a lack of training, device access, and confidence in implementation skills leading to impacts on intervention variability in practice.

Dnp Final Report: Implementing The 5-2-1-0 Lifestyle Framework To Address Elevated Bmi In Pediatric Primary Care, Mary K. Williams

DNP Final Reports

Pediatric obesity remains a significant public health concern, particularly in rural areas where access to specialty care is limited. Primary care settings provide an important opportunity for early identification and intervention through family-based lifestyle modification. The purpose of this quality improvement project was to evaluate the feasibility and preliminary impact of implementing the 5-2-1-0 healthy habits framework, developed by researchers at Penn State, in a rural pediatric primary care clinic to promote improved lifestyle behaviors among children with elevated body mass index (BMI).

This project included pediatric patients ages 5–16 years presenting for well-child visits with a BMI at or …