Medicine and Health Sciences Commons^™

Navigation-Assisted Percutaneous Fixation Of An Anterior Column And Posterior Hemitransverse Fracture In An Elderly Patient: A Case Report., Matthew Rohl, Taylor J Manes, Nate Rodriguez, Kevin Monahan, Joseph P Scheschuk

Surgery Articles

INTRODUCTION: Acetabular fractures in elderly patients are often the result of low-energy trauma and are complicated by osteopenia, comorbidities, and limited physiologic reserve. Minimally invasive approaches, such as percutaneous fixation have emerged as viable alternatives to open reduction in selected fracture patterns.

CASE REPORT: We report the case of a 76-year-old male with a history of coronary artery disease, hypertension, hyperlipidemia, and osteopenia who sustained a comminuted right anterior column and posterior hemitransverse acetabular fracture following a ground-level fall. His hospital course was complicated by rhabdomyolysis and elevated troponin levels, necessitating cardiac evaluation, which demonstrated normal left ventricular function and …

The Correlation Of Vitamin D Deficiency On Clinical Disease Activity Index (Cdai) Scores In Patients With Rheumatoid Arthritis, Ruha Reddy, Amanda Rodriguez Do, Amy Wu, Jasmine Sturn, Rachel Champagne, Rebekah Johnson, Marie S. O'Brien Do

USF-LVHN SELECT

No abstract provided.

Association Between Infection With Multidrug Resistant Staphylococcus Aureus And Patient Risk Factors, Ariana Virgillio, Emily A. Felton, Josh Alvior, Abigail Eglinton, Deanna N. Becker, Amorce Lima, E Cella, T Azarian, Suzane Silbert, Lindsey N. Shaw, Kami Kim

USF-LVHN SELECT

No abstract provided.

Lehigh County Harm Reduction Women’S Outreach, Linda Schiller, Abby S. Letcher Md, Nyann Biery Ms, Heather Diehl, Carnen Ortiz, Bryant Rivera, William Delgado

USF-LVHN SELECT

No abstract provided.

A Comparative Operational Analysis Of Patient Access And Clinician Productivity: Identifying Success Drivers In Pediatric Gastroenterology, Lionel Sam, Liborio Larussa Md

USF-LVHN SELECT

No abstract provided.

Youth Suicide Across The Lehigh Valley Health Network Region:Determining Common Lethal Means Used Locally, Madeline Pollak, Emmanuel Annor Md, Rebecca Lipscomb, Dhanalakshmi Ramasamy Md

USF-LVHN SELECT

No abstract provided.

Characterization Of Transgender Men Undergoing Hysterectomy At The Lehigh Valley Health Network, Christine Peng, Shae Duka Mph, Patricia L. Mara Md

USF-LVHN SELECT

No abstract provided.

An Assessment Of Brain Mri Utilization In Inpatient Admissions For Headache And Dizziness At Lehigh Valley Health Network, Srijit Paul, Shadi Jarjous Md

USF-LVHN SELECT

No abstract provided.

Real-World Challenges Associated With Assembling Multicenter Radiomics Dataset, Wai Lone Jonathan Ho, Lawrence O. Hall, Dmitry Goldgof, Matthew B. Schabath

USF-LVHN SELECT

No abstract provided.

Patient Education Quality Improvement Initiative On Common Neuro Ophthalmology Diagnoses, Rithvic Jupudi, Casey Judge Do, Negar Moheb Md

USF-LVHN SELECT

No abstract provided.

Ulcerative Colitis Predominates, Yet Hepatic Progression Mirrors Crohn’S In Primary Sclerosing Cholangitis–Inflammatory Bowel Disease Overlap: A Tertiary Cohort Study, Sunny Kahlon, Megan Pearce, Donna Ortiz, Jennifer Seminerio

USF-LVHN SELECT

No abstract provided.

Safer Opioid Prescribing Practices In Pediatric Surgery:A Multi-Specialty Initiative To Implement Evidence-Based Pain Management Strategies, Grace Lee, Carly Miller, Rebecca Lipscomb, Amy L. Serfas Bsn, Rn, Marybeth Browne Md

USF-LVHN SELECT

No abstract provided.

Preliminary Evidence Of Blood Dna Methylation Changes In Pregnant Women Adhering To A Mediterranean Diet, Grace Tavelli, Nikki Schultz, Joanna Brisbane, Nina Kresoje, Samantha Lodge, Jeremy K. Nicholson, Nicola J. Armstrong, Desiree Silva, Nina D’Vaz, David Martino

Research outputs 2022 to 2026

Background/Objectives: Consumption of a Mediterranean diet (MD) has been associated with reduced incidence of non-communicable diseases and reduced overall mortality, with epigenomic effects representing plausible mediators. The aim of this pilot study was to explore potential epigenetic associations between DNA methylation markers in blood and adherence to an MD in pregnancy. Methods: Fifty-two pregnant women with high or low adherence to an MD throughout pregnancy, who participated in the BioMood ORIGINS study, were selected using an extremes-of-exposure design. DNA methylation (DNAm) profiles from whole blood were generated using the TWIST human methylome panel. We conducted both genome-wide and candidate gene-based …

Digital Pain Assessment: Patient And Family Perspectives, Rosemary Saunders, Kate Crookes, Kaoru Nosaka, Olivia Gallagher, Jeff Hughes, Caroline Bulsara, Max K. Bulsara, Seng Giap Marcus Ang, Beverley Ewens, Sue Haydon, Karla Seaman, Renée Graham, Debra Scaini, Karen Gullick, Michelle Gay, Christopher Etherton-Beer, Renée Graham

Research outputs 2022 to 2026

Background/Objectives: Pain is a common symptom for hospitalised older adults. Pain is not always adequately assessed, which can lead to inadequate pain management and adverse patient outcomes. Thus, new technology-driven pain assessment tools have been developed; however, little is known about patients’ and families’ experiences of nurses using them in acute care. This study aimed to explore the perspectives of older adult inpatients and their families’ regarding nurses’ use of the digital technology-driven pain assessment application PainChek^® Universal. Methods: A survey was undertaken as part of a stakeholder evaluation of a randomised control trial exploring the effectiveness of nurse-led …

Grwd1 Inhibits Nucleolar Stress And Reduces The Sensitivity Of Hepatocellular Carcinoma To Oxaliplatin., Yuanyuan Li, Yumeng Wu, Shenghuan Zuo, Wenjing Zhao, Jibin Liu, Yilang Wang, Xiubing Zhang, Jian Xu, Feng Sun, Dianzheng Zhang, Shudong Zhu, Aiguo Shen

PCOM Scholarly Works

No abstract available

A Comprehensive Biomechanical Material Characterization Of The Human Breast Fibro-Structural Support System, Aroj Bhattarai, Gregory P Reece, Kristy K Brock, Krishnaswamy Ravi-Chandar

Faculty, Staff and Student Publications

Breast surgery for aesthetic purposes, such as breast augmentation or breast reduction, and breast reconstruction after cancer treatment require an accurate structural (anatomical) and mechanical (functional) understanding of the breast components, including the fascial-ligamentous support system of the breast, to achieve optimal results. This paper aims to provide a comprehensive description of the mechanical behavior of the ligamentous and fascial connective tissues of the human female breast. Fasciae and ligaments obtained from 17 patients between 35 and 85 years of age who were undergoing mastectomy and three female cadavers were tested. Uniaxial tensile tests were conducted, and three constitutive models …

Hyperacute Effects Of Non-Code Dose Bolus Epinephrine In Paediatric Cardiac Intensive Care Patients: Insights From High-Fidelity Physiologic Data., Wesam Sourour, Michael Evans, Kevin Le, Saul Flores, Juan S. Farias, Rohit Seth Loomba

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Non-code dose boluses of epinephrine are utilised in critically ill paediatric patients during periods of hemodynamic deterioration, often with the hopes of preventing a cardiac arrest. Data regarding the physiologic effects of these administrations are limited. The primary aim of this study was to use high-fidelity physiologic data to characterise the effects of intravenous non-code dose bolus epinephrine.

METHODS: Paediatric patients in the cardiac ICU who received non-code dose bolus epinephrine were identified. Those who received fluid boluses or chest compressions within 2 minutes of bolus epinephrine were excluded. Autoregressive integrated moving average analyses with exogenous variables were conducted …

Glomerular Transcriptome Analysis Reveals Endothelial Disturbances In Patients With Idiopathic Nephrotic Syndrome., Sarah K. Nelson-Taylor, Jonathan Troost, Courtney Giannini, Colin Bauer, Tarak Srivastava, Jarcy Zee, Markus Bitzer, Laura Barisoni, Llse Daehn, Julie A. Dougherty, William E. Smoyer, Bryce A. Kerlin, Audrey Fetsko, Imtiazul Islam, Xin Wang, Christine Sethna, Richard J. Johnson, Carmen De Lucas Collantes, Kazunari Kaneko, Gabriel Cara-Fuentes

Manuscripts, Articles, Book Chapters and Other Papers

RATIONALE & OBJECTIVE: Idiopathic nephrotic syndrome (INS) is viewed as a podocyte-specific disease. Recent reports indicate endothelial involvement, but its significance is unclear. Here, we investigated the relationship between the glomerular expression of selected genes relevant to endothelial health and clinical markers of disease severity.

STUDY DESIGN: A cross-sectional study.

SETTING & PARTICIPANTS: Patients with INS (n = 70 minimal change disease and n = 83 focal segmental glomerulosclerosis) from the Nephrotic Syndrome Study Network cohort study and 53 control participants. Validation studies, including animal and cell culture experiments, were performed.

EXPOSURE: Gene expression analysis from micro-dissected human glomeruli. The …

Enhancing Pediatric Tube Weaning With Remote Patient Monitoring: A Pilot Quasi-Experimental Study, Sarah T. Edwards, Dana Bakula, Kristina Nash, Saiyara Baset, Amy Ricketts, Julianne Brogren, Ryan M. Thompson, Sarah Bullard, Rachel Graham, Janelle R. Noel-Macdonnell Phd, Brenda Fetter, Lori A. Erickson

Manuscripts, Articles, Book Chapters and Other Papers

Objective: Feeding-tube weaning is conducted in both inpatient and outpatient settings, with significant logistical, financial, and structural barriers to both approaches. We sought to assess whether remote patient monitoring (RPM), using a mobile application, which would overcome many of these barriers, could be effective in helping patients tube wean. Methods: We prospectively enrolled patients with a feeding tube, aged 0–3 years. Enrolled families entered data daily into the remote application. Data were monitored by a nurse and reviewed weekly by a multidisciplinary team. A standard hunger provocation protocol was used, paired with medical, behavioral, oral motor, and nutrition interventions, as …

Improving Vaccination In People With Ckd: Report From A National Kidney Foundation Working Group, Susan F. Massengill, Kenneth A. Andreoni, Keith A. Bellovich, Cheryl Courtlandt, Vimal K. Derebail, David L. Feldman, Gia J. Oh, John W. Sleasman, Kristina A. Bryant, Improving Vaccination In Ckd Working Group

Department of Surgery Faculty Papers

People with chronic kidney disease (CKD) are particularly vulnerable to vaccine-preventable infections. Therefore, the National Kidney Foundation organized a multidisciplinary working group, including people with CKD and family care partners, to develop recommendations to improve vaccination rates, vaccination effectiveness, and health care for the CKD population. A modified Delphi process was used to achieve consensus on the recommendations. Recommendations on vaccination in CKD patients were organized into these categories: (1) patient preferences; (2) assessing the vaccination status of patients with CKD; (3) assessing vaccine response in patients with CKD; (4) vaccination of immunocompromised patients; (5) vaccination in posttransplant patients; (6) …

A Physician Survey On Research And Implementation Priorities For Caffeine Citrate Use In Newborn Care In Sub-Saharan Africa, Olufunke Bolaji, Osayame Ekhaguere, Franck Houndjahoue, Nicholas Embleton, Helen Nabwera

Centre of Excellence in Women and Child Health

Background:Evidence on caffeine citrate (CC) for apnoeaof prematurity (AOP) originate from high-income countries. This study aimed to develop consensus on research design for evidence in sub-Saharan Africa (SSA).

Methods:We surveyed physicians in newborn units across SSA to assess their opinions on CC research and their preferred study designs.

Participants rated four study designs:a) an observational before-and-after study; a randomized controlled trial (RCT) of b) caffeine versus placebo; c) caffeine versus aminophylline; d) a traditional or stepped wedge cluster trial.  They  assessed  each  design  using  a  Likert  scale  for  evidence, feasibility, and ethics considerations.

Results:Ninety-two   newborn   physicians …

Adapting Lessons From The Indian Subcontinent To Accelerate Elimination Of Visceral Leishmaniasis As A Public Health Problem In East Africa, Eva Iniguez, Daniel Masiga, Caryn Bern, Sridhar Srikantiah

All Peer-Reviewed Publications

This viewpoint draws lessons from the elimination of visceral leishmaniasis (VL) as a public health problem in the Southeast Asia region (SEAR) to inform efforts in East Africa (EA), now the global epicenter of Leishmania donovani transmission. VL is fatal and there is no licensed vaccine. Success in India relied on robust surveillance, rapid diagnosis, single-dose treatment, vector control, and multi-partner coordination. EA faces additional challenges than SEAR with multiple sand fly vectors, sensitive diagnostics and longer treatment regimens, high population mobility, and gaps in ecological and epidemiological knowledge. We highlight how strategies from South Asia could be adapted while …

Entangled Transitions: How Covid-19 Widened Well-Being Gaps Among Youth In Singapore (2017–2022), Vincent Chua, Han Ei Chew, Isabelle Tan, Pamela Lee

Research Collection Office of Impact

COVID-19 was not merely a biomedical crisis but a deeply social phenomenon entangled with existing inequalities. Drawing on Peter Kelly's notion of entanglement, we conceptualise the pandemic as an intersectional crisis − where time, structural disadvantage and socio-emotional well-being became interwoven. Using six waves of longitudinal data (2017–2022) from Youth STEPS, a panel study of young people in Singapore, we track within-person changes in life satisfaction across key youth transitions before, during and after the pandemic. Our findings show that the negative effects of unemployment and insecure work on well-being were markedly more severe during the pandemic than in earlier …

Geographic Access To Pediatric Ecmo And Ecpr: A Geospatial Study Of Transport Networks And Disparities., Allan M. Joseph, Andrew J. Lautz, Carlie N. Myers, Ranjit S. Chima, Juan P. Gurria, Shafee Salloum, Wendy Hasson, Matthew P. Malone, Jenna Miller, Maya L. Dewan

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND AND AIM: Extracorporeal membrane oxygenation (ECMO) can help children survive severe cardiac and/or respiratory failure, but it is only provided in specialized centers. There are disparities in access by ground transport to ECMO services, but it is unknown to what extent interfacility transfer systems can expand access. Additionally, the number of children who live in proximity to centers that perform extracorporeal cardiopulmonary resuscitation (ECPR) to be potential candidates in case of out-of-hospital cardiac arrest (OHCA) is unknown. We conducted a geospatial analysis to answer these questions.

METHODS: We conducted a geospatial analysis of the Extracorporeal Life Support Organization (ELSO) …

Acute Schistosomiasis In A Traveler Returning From St. Croix, United States Virgin Islands: A Case Report., John Weis, Mackenzie Caruthers, Megan Buller

Ambulatory and Primary Care Articles

In this case report, we describe a patient who presented to their primary care provider with abdominal pain after returning from travel to the Caribbean island of St. Croix. The patient reported two weeks of epigastric abdominal pain, dyspepsia, nausea, and night sweats. Following an initial evaluation that revealed eosinophilia with unclear etiology, they were referred to an infectious disease clinic. Through a targeted infectious evaluation and workup, the patient was diagnosed with acute schistosomiasis syndrome and was treated with praziquantel. Treatment resulted in the complete resolution of her symptoms, and follow-up laboratory evaluation showed complete resolution of her eosinophilia. …

Cdk4/6 Inhibition Mitigates Chemotherapy-Induced Expansion Of Tp53-Mutant Clonal Hematopoiesis, Irenaeus C C Chan, Giulia Petrone, J Scott Beeler, Duc Tran, Griffen Mustion, Catrina Fronick, Carlos Cruchaga, Kelly L Bolton, Et Al.

2020-Current year OA Pubs

Therapy-related myeloid neoplasm (tMN) is a fatal consequence of exposure to cytotoxic therapy administered in the treatment of cancer. Individuals with pre-existing TP53 clonal hematopoiesis (CH) are at high risk of tMN, with avoidance of therapy being the only strategy to reduce tMN risk. Here, in four randomized clinical trials, we show that the CDK4/6 inhibitor trilaciclib, given in conjunction with a variety of chemotherapeutic regimens and across diverse populations of patients with cancer, mitigates chemotherapy-related expansion of CH clones with mutations in DNA damage response genes, including TP53. This finding was also observed in a syngeneic mouse model of …

03-17-26 Bor Hsc Committee Notice Of Meeting, Patricia Serna

HSC Committee (A subcommittee of the UNM Board of Regents)

03-17-26 BOR HSC Committee Notice of Meeting

Designing A Telemedicine-Supported Delirium Triage Pathway For Skilled Nursing Facilities: An Evidence-Based Pilot Framework, Benjamin Antill, Eric W. Bean Do, Tara Fritch Ma, Kate Huck Mba, Nha

USF-LVHN SELECT

No abstract provided.

An Evaluation Of Mupirocin Susceptibility Of Methicillin-Resistant Staphylococcus Aureusisolates At Lehigh Valley Health Network, Shreya Arora, Alex Benjamin Md, Amy Slenker Md

USF-LVHN SELECT

No abstract provided.

Detection Of Adaptive Immune Receptor Cdr3s In Tumor Proteomes And Correlations With Survival Probabilities, Arpan Sahoo, Eddie Fung, Taha Huda, Brosi Chobrutskiy, Veda Naga Priya Vangala, George Blanck

USF-LVHN SELECT

No abstract provided.