Medicine and Health Sciences Commons^™

Dietary Flavonoid Intake And Psychological Well-Being – A Bidirectional Relationship, Alysha S. Thompson, Nicola P. Bondonno, Yan Lydia Liu, Farah Qureshi, Laura D. Kubzansky, Claudia Trudel-Fitzgerald, Julia K. Boehm, Eric B. Rimm, Aedín Cassidy

Research outputs 2022 to 2026

Background and aim: Higher dietary flavonoid intake has been associated with lower risks of mortality and major chronic disease, yet its relationship with psychological well-being (PWB), a key contributor to health and quality of life, remains unclear. This study aimed to investigate bidirectional associations between dietary flavonoid intake and two PWB facets: happiness (positive emotional state) and optimism (generalized expectation of positive outcomes). Specifically, we examined whether (1) overall flavonoid-rich dietary patterns (flavodiet score), (2) intake of specific flavonoid-rich foods, and (3) total flavonoid and subclass intakes were each associated with happiness and optimism over time. Methods: Data were drawn …

Neutrophil Gelatinase-Associated Lipocalin And Neutrophil-To-Lymphocyte Ratio As Indicators Of Nephropathy In Type 2 Diabetic Mellitus Patients In Ghana: A Case-Control Study, Allwell Adofo Ayirebi, Wina Ivy Ofori Boadu, Stephen Twumasi, Samuel Kwarteng, Benedict Sackey, Lilian Antwi Boateng, Joseph Boachie, Samuel Essien-Baidoo, Daniel Nii Martey Antonio, John Agyemang Sah, Afua Marfowaa, Mayfair Adwapa Mpiani, Joachim Baba Domosie, Abiba Khalifah, Emmanuel Ekow Korsah, Ebenezer Senu, Eugene Arele Ansah, Joseph Yorke, Enoch Odame Anto

Research outputs 2022 to 2026

Introduction: Serum neutrophil gelatinase-associated lipocalin (sNGAL), a renal tubular marker, and neutrophil-to-lymphocyte ratio (NLR), a hematological inflammatory marker are two biomarkers that have recently received attention, because of their association with kidney disease. This study examined the diagnostic value sNGAL and NLR in type 2 diabetes mellitus (T2DM) patients with nephropathy. Materials and Methods: In this hospital-based case-control research, 97 T2DM participants and 70 healthy subjects were included. Participants' information was documented using a structured questionnaire and patient case records. Venous blood was drawn from each participant and early morning midstream urine samples were collected for blood and urine measurements …

Remodeling Of The Mouse Liver And Skeletal Muscle Metabolome In Response To Continuous Acute Exercise And Disruption Of Ampk-Glycogen Interactions, Mehdi R. Belhaj, David I. Broadhurst, Thomas Dignan, Jamie Whitfield, Lisa Murray-Segal, Naomi X.Y. Ling, Jonathan S. Oakhill, Bruce E. Kemp, John A. Hawley, Stacey N. Reinke, Nolan J. Hoffman

Research outputs 2022 to 2026

Background/Objectives: Acute exercise remodels many interconnected biochemical pathways in metabolically active tissues. This remodeling involves the activation of the energy-sensing AMP-activated protein kinase (AMPK) to maintain cellular energy homeostasis. Critical energy reserves of glycogen, primarily stored in liver and skeletal muscle and known to interact with AMPK, are utilized to help meet increased energy demands with exercise. However, the breadth of metabolic pathways regulated by acute exercise and AMPK’s interactive roles with glycogen remain incompletely understood. This study therefore aimed to map mouse liver and skeletal muscle metabolite responses to continuous acute exercise and disruption of AMPK-glycogen interactions. Methods: Liquid …

The Emerging Role Of Tertiary Lymphoid Structures As Predictive And Prognostic Biomarkers Of Immunotherapy In Cancer, Lidia B. Medhin, Rodas Amanuel, Lydia Warburton, Leslie Calapre, Benhur Amanuel, Elin S. Gray

Research outputs 2022 to 2026

Background: Immune checkpoint inhibitors (ICIs) have improved outcomes across several cancers, yet many patients do not respond, highlighting the need for robust predictive biomarkers. Tertiary lymphoid structures (TLS), ectopic lymphoid aggregates that support local antigen presentation and adaptive immune activation, have emerged as potential indicators of favourable prognosis and immunotherapy responsiveness. Methods: This review summarises current clinical and translational evidence examining the prognostic and predictive value of TLS in solid malignancies. Studies assessing TLS presence, organisation, and biological function were identified through searches of major scientific databases and evaluated with respect to their association with patient outcomes and responses to …

Skeletal Muscle Health In Childhood Cancer Survivors: A Systematic Review And Meta-Analysis, Anna Maria Markarian, Dennis R. Taaffe, Daniel A. Galvão, Carolyn J. Peddle-Mcintyre, Jodie Cochrane Wilkie, Francesco Bettariga, Nicholas G. Gottardo, Mayank Dhamija, Santosh Valvi, Catriona M. Buchanan, Kerrie Graham, Robert U. Newton

Research outputs 2022 to 2026

Purpose: Childhood cancer survivors (CCS) are at risk of long-term skeletal muscle deficits following intensive therapies during critical periods of growth. This review aimed to synthesize approaches for assessing muscle quantity, quality, and function in CCS and to quantify deficits relative to healthy peers. Methods: A systematic search was conducted in CINAHL, Embase, PubMed, SPORTDiscus, and Web of Science from inception to June 2024, with an update in November 2025. Studies including CCS who had completed cancer treatment and reported measures of muscle quantity, quality, or physical function were eligible. A three-level mixed-effects model meta-analysis was conducted. Associations between muscle …

Vibostolimab Coformulated With Pembrolizumab Versus Pembrolizumab Alone As Adjuvant Therapy For High-Risk Stage Iib–Iv Melanoma (Keyvibe-010): A Randomised, Double-Blind, Phase 3 Study, Reinhard Dummer, Jun Guo, Jason J. Luke, Matteo S. Carlino, Dirk Schadendorf, Muhammad A. Khattak, Axel Hauschild, Paolo A. Ascierto, Yu Chen, Sang Joon Shin, Piotr Rutkowski, Zhiguo Luo, Jing Chen, Gareth Rivalland, Corlia Coetzee, Antoni Ribas, Karmele Mujika, Gal Markel, Rodrigo U. Villarroel, Omer Dizdar, Christian Caglevic, Dmitri Grebennik, Kevin Donovan, Clemens Krepler, Georgina V. Long

Research outputs 2022 to 2026

Background Combination therapy with vibostolimab plus pembrolizumab has previously shown promising antitumor activity in melanoma. We aimed to evaluate the efficacy and safety of vibostolimab coformulated with pembrolizumab as adjuvant therapy for high-risk resected melanoma. Methods This randomised, double-blind, phase 3 study was done at 205 global sites (hospitals and cancer centres). Participants aged 12 years or older with surgically resected, stage IIB–IV cutaneous melanoma per the American Joint Committee on Cancer Cancer Staging Manual 2017 (8th edition), with no evidence of metastatic disease after resection, were randomly assigned (1:1) to receive vibostolimab 200 mg coformulated with pembrolizumab 200 mg …

Assessment Of Rotator Cuff External Rotation: Isometric Vs. Isotonic Testing Modes, Luca Maestroni, Filippo Beretta, Fabio Civera, Paolo Artina, Marco Cuniberti, Francesco Bettariga, Anthony Turner

Research outputs 2022 to 2026

Objectives: To assess intra-session reliability of isometric and isotonic shoulder external rotation (ER) strength tests and to compare their outcomes. Methods: Thirty-eight healthy subjects (19 females; 19 males; 25.7 ± 6.0 years; 175 ± 9 cm; 70.3 ± 11.4 kg) completed a shoulder ER strength assessment including Prone and Standing ER Isometric tests and Seated 5 repetition maximum (RM) ER tests. Normality was checked with the Shapiro–Wilk test. Reliability was assessed using the CV and ICC (3, k, 95% CI). Linear mixed models examined sex and dominance effects. Correlations and multiple regression tested associations between tests (p < 0.05). Results: All tests performed displayed “excellent” reliability scores (CV from 1.9 to 3.1% and ICC from 0.970 to 0.994). No significant effect of dominance was observed in any strength test. Males showed significantly higher values than females in both Prone (3.8% higher, p < 0.001) and Standing (2.7% higher, p = 0.003) isometric ER strength tests. Prone and Standing isometric tests were moderately correlated (r = 0.62, 95% CI [0.46, 0.74], p < 0.001). A regression model explained 52.4% of the variance in Seated 5 RM ER strength (R² = 0.524, …

A Joint Effort: Stakeholders' Perspectives Of Medication Management Reviews In Australian Residential Aged Care, Rajendra Gyawali, Marea O'Donnell, Rachel Jenkins, Amy D. Nguyen, Lalit Yadav, Rosemary Saunders, Fiona J. Clay, Johanna I. Westbrook, Karla Seaman, Magdalena Z. Raban

Research outputs 2022 to 2026

Objective: Residential Medication Management Review (RMMR) is a government-funded pharmacist-led service to address medication-related problems, such as polypharmacy, which are prevalent in aged care. Despite known benefits, concerns remain about the service's effective implementation to benefit residents. We aimed to explore stakeholders' perspectives of the service and identify challenges and improvement opportunities. Method: A qualitative study was conducted using individual interviews and focus groups with 21 stakeholders, including general practitioners (GPs), a nurse practitioner, registered nurses, pharmacists and consumers. Audio transcripts of the discussions were thematically analysed using inductive coding. Results: Seven interconnected themes were identified, highlighting complexities in RMMR …

Mini-Course On Community Resources For Patients With Disabilities, Abigail Weisse, Vinita Kiluk, Kyle Lien, Nora Newcomb, Aishwarya Vuppala, Franklin Sun, Shannon Mccarthy, Anita Narkhede, Marjorie Fitzsimmons

USF-LVHN SELECT

No abstract provided.

Point-Of-Care Vision Correction: A Pilot Study Of Mobile Refractive Screening And Same Day Glasses Distribution In A Street Medicine Program, Tejasvi Paturu, Veena Jajoo, Emily Coughlin, Rebecca Lipscomb, Seth A. Campbell Pa-C

USF-LVHN SELECT

No abstract provided.

Socioeconomic Profiles And Barriers Among Committed Female Juveniles In The Florida Department Of Juvenile Justice, Aishwarya Vuppala, Kristopher Kaliebe, Sherry Jackson, Jorge Hernandez

USF-LVHN SELECT

No abstract provided.

A Retrospective Cohort Study Exploring Predictive Factors Of 30-Day Mortality In Intracerebral Hemorrhage Patients, Alan R Spicer, Veena Jajoo, Rahul Mhaskar, Marla Hairston, Crystal Dixon, W Scott Burgin

USF-LVHN SELECT

No abstract provided.

A Case Series Of Hypokalemia And Hypertension In Pregnancy, Pooja Neerumalla, Sharon E. Maynard Md, Sejal Lakhani Do

USF-LVHN SELECT

No abstract provided.

Sexually Transmitted Infections At A Health Clinic Serving Older Adolescents And Young Adults: An Analysis Of Demographics, Health Care Access, And Positivity Rates, Shaliz Aflatooni, Margaret Van Cleve, Anna Sizemore, Sarah A Commaroto, Emily Coughlin, Rahul Mhaskar, Carina A. Rodriguez, Lisa J. Sanders

USF-LVHN SELECT

No abstract provided.

Baseline Assessment Of Advance Care Planning Documentation Among High-Risk Ed Patients, Sierra Barber, Marna R. Greenberg Do, Mph, Facep

USF-LVHN SELECT

No abstract provided.

Subdural Hematomas At A Cancer Center: Large Retrospective Review Of Survival And Prognostic Indicators, Samuel Bauserman, Trevor Pharr, Samantha Schimmel, Bassel El Sayed, Alexander Becker, Andre Beer-Furlan

USF-LVHN SELECT

No abstract provided.

Enhancing Prenatal Detection Of Fetal Cardiac Pathologies Using Fetoly-Heart Software: A Performance Study, Alexander Behzadi, Sean Daneshmand, Arij Faksh, Mishella Perez

USF-LVHN SELECT

No abstract provided.

Assessing Evidence-Based Care In Hospitalized Lyme Disease: A Quality Improvement Study, Quentin Boose, Raul E Davaro Md

USF-LVHN SELECT

No abstract provided.

Examining Psychosocial And Demographic Correlates Of Sleep Disturbances At A Home For Youth Experiencing Housing Instability, Elizabeth G Chiu, Alisa Vidwans, Amy B. Smith Phd

USF-LVHN SELECT

No abstract provided.

Perspectives Of African American Mothers On Breastfeeding Support During Newborn Hospitalization: Addressing Disparities In Breastfeeding Exclusivity, Melissa Chow, Sarah A Commaroto, Kaen Fugate, Karyn Gerstle

USF-LVHN SELECT

No abstract provided.

Life After Parent Training: 3- And 6-Month Follow Up Of Hot Docs, Sarah A Commaroto, Sarah Dickinson, Heather Agazzi

USF-LVHN SELECT

No abstract provided.

Preoperative Neighborhood Socioeconomic Deprivation And Patient Reported Quality Of Life In Bladder Cancer Patients Undergoing Radical Cystectomy, Anosh Dadabhoy, Farshad S. Moghaddam, Siamak Daneshmand

USF-LVHN SELECT

No abstract provided.

Implementation Of A Visual Brochure Outlining Breastfeeding Policies To Improve Awareness For Employees At Lvhn, Karim Girgis, Autumn Kieber-Emmons Md, Mph

USF-LVHN SELECT

No abstract provided.

Bacillus Calmette-Guérin–Exposed Non–Muscle-Invasive Bladder Cancer: Survival Benchmarks, Bladder-Sparing Strategies, And Implications For Trial Design, Seyed Behzad Jazayeri, Renzo G. Dinatale, Christopher W Guske, Christian Harrs, Joshua Linscott, Hongzhi Xu, Facundo Davaro, Lexiaochuan Wen, Philippe E. Spiess, Wade J. Sexton, Scott M. Gilbert, Logan Zemp, Michael Poch, Roger Li

USF-LVHN SELECT

No abstract provided.

Does Treating Iron Deficiency Decrease Disease Severity And Improve Functionality For Rheumatoid Arthritis Patients?, Xinyi Jing, Emily Coughlin, Marie S. O’Brien Do

USF-LVHN SELECT

No abstract provided.

What Are We Doing Right? A Qualitative Analysis Of Health Disparity Conversations With Lgbtq+ Older Adults, Skylar Lung, Ashlee Randolph, Nyann Biery Ms, Lynn M. Wilson Do

USF-LVHN SELECT

No abstract provided.

Prevalence And Risk Factors For Non-Hacek Gram-Negative Bacillus Endocarditis: A Retrospective Analysis, Jason H Park, Edwin Chen, Divyia E Joseph, Audrey Wanger, J Alex Viehman, Simi Padival

Faculty, Staff and Student Publications

Background: Infective endocarditis (IE) caused by non-HACEK gram-negative bacilli (GNB) is challenging to diagnose and is associated with high morbidity and mortality. There is growing literature highlighting the differences in IE prevalence amongst various GNB; therefore, there is an impetus to characterize these traditionally "atypical" organisms to accurately risk stratify this complex infectious diagnosis.

Methods: This investigation was a retrospective cohort study conducted at 2 health care institutions in the USA. All hospitalized adult patients with bloodstream infection with a prespecified GNB (Enterobacter cloacae, Escherichia coli, Klebsiella aerogenes, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, and Serratia marcescens) between January 1, …

Physical And Occupational Therapist Evaluations For Fall Prevention In The Emergency Department: A Geriatric Ed Guidelines 2.0 Systematic Review, Lauren T Southerland, Pedro K Curiati, Richard D Shih, Alexander X Lo, Kristie Harper, Ian Tarnovsky, Alexis Brengartner, Luna Ragsdale, Neha Raukar, Suzanne Ryer, Katherine M Hunold, Fabrice Mowbray, Charles L Maddow, Christopher R Carpenter, Shan W Liu

Faculty, Staff and Student Publications

Background: Older adults are at high risk for severe injuries and death from falls. Physical therapist (PT) and occupational therapist (OT) evaluations have been introduced into Emergency Department (ED) care to assist with fall risk evaluation and fall prevention care. An evaluation of current evidence was undertaken to inform the Geriatric ED Guidelines 2.0.

Methods: Systematic review of physical and/or occupational therapy evaluation for fall prevention in the ED. The intervention was evaluation by a rehabilitation therapist (PT, OT, or both) for fall prevention, fall assessment, or mitigation of fall risk factors. Studies that did not perform the evaluation during …

Transcatheter Aortic Valve Replacement In Systemic Sclerosis: A Case Series And Review Of Short- And Long-Term Outcomes, Chris T. Derk, Ahmadreza Badali, Esra Mehmetoglu, Anvitha Mummadisetty, Amit Syal, Konstantinos Parperis

Student Papers, Posters & Projects

Objectives: A higher frequency of valvular heart disease is seen among Systemic Sclerosis (SSc) patients. Advanced aortic valve stenosis leads to significant morbidity in these patients with multiple other comorbidities. In this study, we aim to define the short- and long-term outcomes of transcatheter aortic valve replacement (TAVR) procedures in SSc patients. Methods: We undertook a retrospective chart review of all patients with SSc who underwent a TAVR procedure at our institution over a defined 11-year period. Demographics as well as short- and long-term outcomes were identified. Results: Fourteen SSc patients underwent a TAVR procedure between 2012 and 2023. They …

Text Messages To Improve Young Child Diets: Results From A Cluster-Randomized Controlled Trial In Kanchanpur, Nepal, Kenda Cunningham, Sidney Cech, Aman Sen Gupta, Pooja Pandey Rana, Debbie Humphries, Edward A. Frongillo Jr. Ph.D.

Faculty Publications

The objective of this study was to test whether adding a text message campaign about the importance of eating eggs and other nutrition-related behaviours to an on-going package of large-scale, diverse social and behaviour change interventions would improve four types of nutrition-related knowledge and behaviour outcomes: child diets (egg consumption as the primary outcome), maternal diets, maternal nutrition knowledge, and maternal participation in additional interventions. The cluster-randomized controlled trial involved a repeat cross-sectional design, recruiting families with children 12–23 months of age at baseline and endline in one plains district of Nepal. Throughout the 1000-day period, 51 text messages were …