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Articles 31 - 60 of 137
Full-Text Articles in Medicine and Health Sciences
Vitamin C Modulates Oxidative Stress-Induced Colitis In Rats, Mustafa Zeri̇n, Ali̇ Zi̇ya Karakilçik, Muharrem Bi̇ti̇ren, Davut Musa, Abdullah Özgönül, Şehabetti̇n Selek, Yaşar Nazligül, Ali̇ Uzunköy
Vitamin C Modulates Oxidative Stress-Induced Colitis In Rats, Mustafa Zeri̇n, Ali̇ Zi̇ya Karakilçik, Muharrem Bi̇ti̇ren, Davut Musa, Abdullah Özgönül, Şehabetti̇n Selek, Yaşar Nazligül, Ali̇ Uzunköy
Turkish Journal of Medical Sciences
Free radicals are an important factor in the etiopathogenesis of colitis and may increase oxidative damage. The antioxidant vitamin C efficiently scavenges free oxygen radicals. The present study aimed to investigate the probable protective effects of vitamin C on oxidative injury in rats in which colitis was experimentally induced with acetic acid. Materials and methods: This study was conducted with rats for a period of 7 days. Group 1 intrarectally received a placebo (0.9% NaCl) and group 2 intrarectally received 2 mL of 5% acetic acid (AA) and the placebo. Group 3 intrarectally received 2 mL of 5% AA and …
Comparison Of In Vitro Cytotoxicity And Genotoxicity Of Mma-Based Polymeric Materials And Various Metallic Materials, Sultan Gülçe İz, Sai̇me İsmet Gürhan, Bi̇lge Hakan Şen, Tuğba Endoğan, Nesri̇n Hasirci
Comparison Of In Vitro Cytotoxicity And Genotoxicity Of Mma-Based Polymeric Materials And Various Metallic Materials, Sultan Gülçe İz, Sai̇me İsmet Gürhan, Bi̇lge Hakan Şen, Tuğba Endoğan, Nesri̇n Hasirci
Turkish Journal of Medical Sciences
To determine the in vitro cytotoxicity and genotoxicity of some polymeric and metallic implant materials used as base materials in dentistry, based on ISO (International Organization for Standardization) and OECD (Organization for Economic Co-Operation and Development) test protocols. Materials and methods: Three different acrylate-based polymeric materials were tested for their in vitro cytotoxicity and genotoxicity (polymethylmethacrylate microspheres [PMMA], a solid cement prepared by mixing PMMA with its monomer methylmethacrylate [PMMA+MMA], a solid cement prepared by mixing PMMA, MMA, and hydroxyapatite [PMMA+MMA+HA], as wells as 4 different metallic materials (titanium [Ti grade 4], nickel alloy 625 [Ni-625], stainless steel alloy 304L …
Atypical Clinical Manifestation Of Dementia: A Progressive Visuospatial Deficit, Mehmet Güney Şenol, Hakan Tekeli̇, Erdem Toğrol, Mehmet Saraçoğlu
Atypical Clinical Manifestation Of Dementia: A Progressive Visuospatial Deficit, Mehmet Güney Şenol, Hakan Tekeli̇, Erdem Toğrol, Mehmet Saraçoğlu
Turkish Journal of Medical Sciences
Clinically and neuropathologically dementia is a very heterogeneous disease. Alzheimer's disease (Alzheimer disease, AD), the most common cause of dementia, is an acquired cognitive and behavioral impairment of sufficient severity that markedly interferes with social and occupational functioning. This disease may be manifested as progressive memory problems, visuospatial deterioration, aphasia and/or deficits of executive functions. The patient we report here is a 73-year-old female patient with loss of ability of finding directions and understanding the shapes of materials. Her complaints increased progressively during the last two years. Even if she had retired from tailoring, she had deterioration in the visuospatial …
Histopathologic Changes In The Rabbit Submandibular Gland After 5-Fluorouracil Chemotherapy, Oktay Özel, Abdullah Ayçi̇çek, Fethullah Kenar, Fatma Aktepe, Ramazan Sargin, Mustafa Deni̇z Yilmaz, Fevzi̇ Sefa Dereköy
Histopathologic Changes In The Rabbit Submandibular Gland After 5-Fluorouracil Chemotherapy, Oktay Özel, Abdullah Ayçi̇çek, Fethullah Kenar, Fatma Aktepe, Ramazan Sargin, Mustafa Deni̇z Yilmaz, Fevzi̇ Sefa Dereköy
Turkish Journal of Medical Sciences
To determine the early-stage effects of 5-fluorouracil (5-FU) on the histology of the submandibular gland. Materials and methods: The study included 30 New Zealand rabbits. They were divided into 3 groups. No drugs were administered to group 1 (control group), and 5-FU was administered for 5 days to group 2 and for 10 days to group 3. Submandibular gland excision was then performed. Histopathological examination was performed with hematoxylin-eosin staining, apoptosis was determined based on TUNEL staining, and cell proliferation was examined using the PCNA antibody. Results: While no granular change was seen in group 1, granular change was observed …
Effect Of Passive Smoking On The Development Of Chronic Obstructive Pulmonary Disease In Southeastern Turkey, Teki̇n Yildiz, Füsun Topçu, Yusuf Çeli̇k, Levent Akyildiz, Güngör Ateş, Di̇lek Durak
Effect Of Passive Smoking On The Development Of Chronic Obstructive Pulmonary Disease In Southeastern Turkey, Teki̇n Yildiz, Füsun Topçu, Yusuf Çeli̇k, Levent Akyildiz, Güngör Ateş, Di̇lek Durak
Turkish Journal of Medical Sciences
To determine the effect of passive smoking on the development of chronic obstructive pulmonary disease (COPD) among persons who spend a long time in cafes. Materials and methods: The study sample included 348 male smokers who were older than 40 years and spend a long time in cafes. The questions were derived from the European Coal and Steel Community (ECSC) questionnaire. We also inquired about the nature of cafe visits (hours/day, visits/week, visits/month). Results: COPD was found in 18.1% (63/348 subjects) of the smokers aged >=40 years. In these 63 subjects, based on spirometry results, the rate of mild and …
X-Ray Diffraction Analysis Of Urinary Tract Stones, Turgut Yapanoglu, Azam Demi̇rel, Şenol Adanur, Hi̇kmet Yüksel, Özkan Polat
X-Ray Diffraction Analysis Of Urinary Tract Stones, Turgut Yapanoglu, Azam Demi̇rel, Şenol Adanur, Hi̇kmet Yüksel, Özkan Polat
Turkish Journal of Medical Sciences
To analyze urinary tract stones obtained in our clinic using various methods and to determine the spectrum of stone composition in the Eastern Anatolia Region, Turkey. Materials and methods: A total of 300 stones were obtained at Atatürk University, Faculty of Medicine Urology Clinic through open surgery, percutaneous nephrolithotomy (PNL), ureterorenoscopy (URS), and extracorporeal shock-wave lithotripsy (ESWL) between 1 January 2005 and 30 December 2008. Stones were analyzed in the laboratory of Ankara General Directorate of Mineral Research Exploration using X-ray diffraction (XRD). Results: It was found that 218 (72.7%) of the 300 stones were calcium oxalate (CaOx); 170 (56.7%) …
A Novel Hand-Held Device For The Measurement Of Ocular Alignment, Uğur E. Altiparmak, Esra Karabulut, Eric R. Eggenberger
A Novel Hand-Held Device For The Measurement Of Ocular Alignment, Uğur E. Altiparmak, Esra Karabulut, Eric R. Eggenberger
Turkish Journal of Medical Sciences
The measurement of ocular alignment can be challenging and difficult to reproduce. A method for the measurement of ocular alignment with accuracy, speed, and reproducibility would be a useful clinical addition. Materials and methods: A hand-held device consisting of a rotary prism and a red Maddox rod was constructed. This was used to evaluate 18 patients with ocular misalignment and the results were compared with the ones obtained using the prism cover testing. Results: The results from the hand-held device showed a close correlation with those of the prism cover test. Conclusion: The hand-held instrument is a useful method to …
Caustic Esophageal Injury Decreases The Number Of Interstitial Cells Of Cajal In The Rat Esophagus, Tutku Soyer, Şebnem Ayva, Sali̇h Somuncu, Pinar Atasoy, Turan Kanmaz, Murat Çakmak
Caustic Esophageal Injury Decreases The Number Of Interstitial Cells Of Cajal In The Rat Esophagus, Tutku Soyer, Şebnem Ayva, Sali̇h Somuncu, Pinar Atasoy, Turan Kanmaz, Murat Çakmak
Turkish Journal of Medical Sciences
To evaluate the effect of caustic esophageal injury (CEI) on the number of interstitial cells of Cajal (ICC). Materials and methods: Wistar rats were divided into 3 groups: control, acid, and alkali induced CEI. CEI was performed by the injection of 1 mL of 10% hypochloric acid in the acid group, and 1 mL of 10% sodium hydroxide was injected into the alkali group. Distal esophageal segments were removed 24 h after injection. CEI was graded and the number of ICC were investigated (CD-117 staining). The number of ICC was compared in groups and correlated with CEI grades. Results: Typical …
Comparative Efficacy Of Caffeic Acid Phenethyl Ester (Cape), Olopatadine Hydrochloride, And Dexamethasone Sodium Phosphate In Experimental Allergic Conjunctivitis*, Erdi̇nç Aydin, Heli̇n Deni̇z Demi̇r, Hüseyi̇n Özyurt, Ünal Erkorkmaz
Comparative Efficacy Of Caffeic Acid Phenethyl Ester (Cape), Olopatadine Hydrochloride, And Dexamethasone Sodium Phosphate In Experimental Allergic Conjunctivitis*, Erdi̇nç Aydin, Heli̇n Deni̇z Demi̇r, Hüseyi̇n Özyurt, Ünal Erkorkmaz
Turkish Journal of Medical Sciences
To compare the antiallergic efficacy of 1% caffeic acid phenethyl ester (CAPE), 0.1% olopatadine hydrochloride, and 0.1% dexamethasone sodium phosphate. Materials and methods: Experimental allergic conjunctivitis was provoked by a mast cell activator (compound 48/80) in 31 New Zealand rabbits. The rabbits were divided into 3 groups, and 1% CAPE, 0.1% olopatadine hydrochloride, and 0.1% dexamethasone sodium phosphate were instilled 30 min before and 15 min after the provocation. The edema and hyperemia in the experimental (right) eyes and control (left) eyes were scored in each group. Anterior segment photographs and conjunctival samples for histopathological evaluation and scoring were taken. …
Absence Of Vancomycin-Resistant Enterococci (Vre) Despite The Presence Of Risk Factors: A Survey Of Rectal Carriage Of Vre*, Zeli̇ha Koçak Tufan, Selcan Arslan, Sali̇h Cesur, Cemal Bulut, Hasan Irmak, Sami̇ Kinikli, Ferah Ergi̇n, Ali̇ Kutta Çeli̇k, Ali̇ Pekcan Demi̇röz
Absence Of Vancomycin-Resistant Enterococci (Vre) Despite The Presence Of Risk Factors: A Survey Of Rectal Carriage Of Vre*, Zeli̇ha Koçak Tufan, Selcan Arslan, Sali̇h Cesur, Cemal Bulut, Hasan Irmak, Sami̇ Kinikli, Ferah Ergi̇n, Ali̇ Kutta Çeli̇k, Ali̇ Pekcan Demi̇röz
Turkish Journal of Medical Sciences
The resistant organisms from patients and healthcare workers (HCWs) first colonized the gastrointestinal tract before causing infections in patients. In this study, presence of risk factors for vancomycin-resistant enterococci (VRE) colonization and the prevalence of rectal carriage of VRE among HCWs and hospitalized patients in the absence of an outbreak were investigated. Design: Cross-sectional study. Setting: A 600-bed training and research hospital. Materials and methods: A total of 508 intensive-care unit (ICU) patients and HCWs in these units were included. Risk factors such as previous antibiotic use, especially vancomycin and cephalosporin, the presence of invasive devices like catheters, and co-morbid …
Effects Of Vitamin A And C And Melatonin On 3-Nitrotyrosine Formation In Guinea Pig Heart Under Lipopolysaccharide-Induced Stress, Hali̇l Yaman, Tuncer Çayci, Meli̇k Seyrek, Emi̇n Özgür Akgül, Yasemi̇n Gülcan Kurt, İbrahi̇m Aydin, Hakan Yaren, Erdi̇nç Çakir, Ömer Özcan, Behzat Çi̇men, Nurten Türközkan, Mehmet Kemal Erbi̇l
Effects Of Vitamin A And C And Melatonin On 3-Nitrotyrosine Formation In Guinea Pig Heart Under Lipopolysaccharide-Induced Stress, Hali̇l Yaman, Tuncer Çayci, Meli̇k Seyrek, Emi̇n Özgür Akgül, Yasemi̇n Gülcan Kurt, İbrahi̇m Aydin, Hakan Yaren, Erdi̇nç Çakir, Ömer Özcan, Behzat Çi̇men, Nurten Türközkan, Mehmet Kemal Erbi̇l
Turkish Journal of Medical Sciences
Bacterial lipopolysaccharide (LPS) triggers synthesis of nitric oxide (NO) and superoxide (O_2^{.-}). O_2^{.-} can react with NO to produce the powerful oxidant peroxynitrite (ONOO-). The presence of 3-nitrotyrosine (3-NT) in tissues is often used as a marker of ONOO- production. Vitamin A, vitamin C, and melatonin are potent antioxidant molecules. We sought to clarify this issue by examining the effects of vitamin A (15,000 IU/kg/day), vitamin C (600 mg/kg/day), and melatonin (25 mg/kg) on 3-NT formation in heart tissue in a guinea pig model of LPS-induced endotoxemia. Materials and methods: A total of 75 animals were randomly divided into 5 …
Analysis Of Periprocedural Medical Complications During Carotid Angioplasty And Stent Placement, İsmai̇l Aydin Erden, Almila Gülsün Pamuk, İbrahi̇m Özkan Önal, Burcu Akbay Özkaya, Seda Banu Akinci, Kivilcim Yavuz, Bi̇lge Çelebi̇oğlu, Ülkü Aypar
Analysis Of Periprocedural Medical Complications During Carotid Angioplasty And Stent Placement, İsmai̇l Aydin Erden, Almila Gülsün Pamuk, İbrahi̇m Özkan Önal, Burcu Akbay Özkaya, Seda Banu Akinci, Kivilcim Yavuz, Bi̇lge Çelebi̇oğlu, Ülkü Aypar
Turkish Journal of Medical Sciences
To evaluate periprocedural medical complications during carotid angioplasty and stent placement. Materials and methods: Data of all patients who underwent carotid artery stenting and were admitted to the postanesthesia care unit between January and December 2006 were retrospectively evaluated. All patients received conscious sedation, constant monitoring, and 0.5 mg atropine before balloon inflation. Risk factors and intra- and postprocedural complications were recorded. Results: Twenty-two patients were treated for asymptomatic carotid stenosis and 25 patients for symptomatic carotid stenosis. Of the symptomatic patients 3 presented with retinal symptoms, 15 with a hemispheric transient ischemic attack, and 7 with a minor stroke. …
Dissection Of Mesoappendix In Laparoscopic Appendectomy: A Comparison Of Monopolar Cautery And Bipolar Vessel Sealing System, Emrah Şenel, Fati̇h Akbiyik, Hali̇l Faruk Atayurt, Hüseyi̇n Tuğrul Ti̇ryaki̇
Dissection Of Mesoappendix In Laparoscopic Appendectomy: A Comparison Of Monopolar Cautery And Bipolar Vessel Sealing System, Emrah Şenel, Fati̇h Akbiyik, Hali̇l Faruk Atayurt, Hüseyi̇n Tuğrul Ti̇ryaki̇
Turkish Journal of Medical Sciences
Various technique and different instruments like endoscopic stapler, endoscopic clip, monopolar cautery, harmonic scalpel, and bipolar vessel sealer can be used in the dissection of appendix mesentery when performing laparoscopic appendectomy. The aim of this study is to evaluate the effects of using monopolar cautery and bipolar vascular sealing instruments in the dissection of mesentery of appendix on the duration of the operation of pediatric patients. Materials and methods: Sixty three patients, operated laparoscopically for acute appendicitis in between June 2008 and June 2009 at the Pediatric Surgery Clinic of Dışkapı Children's Hospital, are evaluated retrospectively. Monopolar cautery was used …
Feminizing Genitoplasty: An Evaluation Of 41 Patients In 8 Years, Fati̇h Akbiyik, Hüseyi̇n Tuğrul Ti̇ryaki̇, Emrah Şenel, Ervi̇n Mambet, Yusuf Zi̇ya Li̇vaneli̇oğlu, Hali̇l Faruk Atayurt
Feminizing Genitoplasty: An Evaluation Of 41 Patients In 8 Years, Fati̇h Akbiyik, Hüseyi̇n Tuğrul Ti̇ryaki̇, Emrah Şenel, Ervi̇n Mambet, Yusuf Zi̇ya Li̇vaneli̇oğlu, Hali̇l Faruk Atayurt
Turkish Journal of Medical Sciences
The authors present early results of feminizing genitoplasty procedures. Materials and methods: Medical records of 41 patients who underwent feminizing genitoplasty in between 2001 and 2009 were evaluated retrospectively. Results: Follow-up period was 1 month to 7.5 years. Clitorolabial cosmesis was good in all patients except one. Neither clitoral necrosis nor enlargement was noted in postoperative period. The most common complication observed was vaginal stenosis. For 7 patients with severe stenosis, reoperations are planned at puberty. Conclusion: One-stage or staged genitoplasty is performed for disorders of sexual development (DSD) patients. Although results of clitoroplasty are satisfactory, reoperation rates due to …
Two Siblings With Netherton Syndrome, Selma Emre, Ahmet Meti̇n, D. Deni̇z Demi̇rseren, Ahu Yorulmaz, Aykut Onursever, Burçi̇n Kaftan
Two Siblings With Netherton Syndrome, Selma Emre, Ahmet Meti̇n, D. Deni̇z Demi̇rseren, Ahu Yorulmaz, Aykut Onursever, Burçi̇n Kaftan
Turkish Journal of Medical Sciences
Netherton syndrome (NS) is a rare genodermatosis characterized by autosomal recessive inheritance pattern, unknown etiology, ichthyosiform cutaneous changes, atopic diathesis, and alterations in the hair shaft. As a result of aging coupled with immune deficiency, clinical symptoms may vary. Herein, we present 2 siblings with the characteristic cutaneous symptoms of NS, albeit with some differences between the siblings. Materials and methods: Two sisters presented to our clinic with sparse and brittle hair along with pruritic, erythematous, and scaling cutaneous lesions. Both patients underwent a clinical examination and laboratory analyses. Results: Based on the clinical and laboratory findings, both patients were …
Prevalence Of Cardiac Arrhythmia In Obstructive Sleep Apnea Syndrome, Ni̇hal Akar Bayram, Bülent Çi̇ftçi̇, Selma Firat Güven, Hüseyi̇n Bayram, Hasbi̇ Erdem Di̇ker, Tahi̇r Durmaz, Telat Keleş, Engi̇n Bozkurt
Prevalence Of Cardiac Arrhythmia In Obstructive Sleep Apnea Syndrome, Ni̇hal Akar Bayram, Bülent Çi̇ftçi̇, Selma Firat Güven, Hüseyi̇n Bayram, Hasbi̇ Erdem Di̇ker, Tahi̇r Durmaz, Telat Keleş, Engi̇n Bozkurt
Turkish Journal of Medical Sciences
Repetitive transient activation of the parasympathetic and sympathetic systems in obstructive sleep apnea syndrome (OSAS) constitutes the basis for development of cardiac arrhythmias. We aimed to examine the prevalence of arrhythmias in OSAS. Materials and methods: Eighty-eight patients with suspected OSAS were included in the study. Polysomnography was performed overnight in all patients. Patients with apnea-hypopnea index (AHI) < 5 were considered OSAS negative, while patients with AHI >= 5 were OSAS positive. Arrhythmia was defined as sinus bradycardia, sinus tachycardia, > 10/h supraventricular premature beats (SVPBs), > 10/h ventricular premature beats (VEBs), complex VPBs (bigeminal, trigeminal VEB or nonsustained VT), supraventricular tachycardia, ventricular tachycardia, > 2 s sinus arrest, second or third …
Effects Of Aqueous Garlic Extract On Oxidant/Antioxidant Status In 32d And 32dp210 Cell Lines, Aslihan Avci, Asuman Sunguroğlu, İmge B. Ergüder, Güvem Gümüş Akay, Erdi̇nç Devri̇m, Pinar Özkal Baydin, Nuray Varol, İlker Durak
Effects Of Aqueous Garlic Extract On Oxidant/Antioxidant Status In 32d And 32dp210 Cell Lines, Aslihan Avci, Asuman Sunguroğlu, İmge B. Ergüder, Güvem Gümüş Akay, Erdi̇nç Devri̇m, Pinar Özkal Baydin, Nuray Varol, İlker Durak
Turkish Journal of Medical Sciences
To investigate the possible effects of aqueous garlic extract on the oxidant/antioxidant status and apoptosis in 32D (wild type mouse myeloid cell = normal) and 32Dp210 (BCR-ABL fusion gene (+) mouse myeloid cell = Chronic Myelocytic Leukemia cells) cell lines. Materials and methods: Aqueous garlic extract (10% w/v) was added into the cell line media with 2 different final concentrations (0.4% and 1%). At 0 h and at 24, 48, and 72 h later, the oxidant (malondialdehyde (MDA) level, and xanthine oxidase (XO) enzyme activity) and antioxidant (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) enzyme activities) parameters were …
Reliability Of Self-Reported History In Predicting Immunity Against Measles, Rubella, Mumps, And Varicella Among Health Care Workers, Çi̇gdem Ataman Hati̇poğlu, Ferah Ergi̇n, Günay Tuncer Ertem, Cemal Bulut, Ruki̇ye Berkem, Ali̇ Pekcan Demi̇röz
Reliability Of Self-Reported History In Predicting Immunity Against Measles, Rubella, Mumps, And Varicella Among Health Care Workers, Çi̇gdem Ataman Hati̇poğlu, Ferah Ergi̇n, Günay Tuncer Ertem, Cemal Bulut, Ruki̇ye Berkem, Ali̇ Pekcan Demi̇röz
Turkish Journal of Medical Sciences
To determine the immunity of health care workers (HCWs) against measles, rubella, mumps, and varicella infections, and to evaluate the reliability of self-reported history of the disease in predicting immunity. Materials and methods: A self-reported questionnaire was used to obtain the history of the diseases and ELISA to screen specific IgG antibodies. The history of the diseases was compared with serological testing results. Results: Eighty-one HCWs were included in the study. Immunity against measles was 97.5%, rubella 100%, mumps 72.8%, and varicella 96.3%. Positive predictive values of positive histories of the diseases were 100% for measles and rubella, 96.5% for …
The Effects Of Adjuvant Therapies For Sepsis On Hepatic And Renal Function: A Retrospective Analysis Of 108 Icu Patients, Beri̇t Gökçe Ceylan, Lütfi̇ Yavuz, Füsun Eroğlu, Şenol Gülmen, Ömer Ridvan Tarhan, Adnan Alaca
The Effects Of Adjuvant Therapies For Sepsis On Hepatic And Renal Function: A Retrospective Analysis Of 108 Icu Patients, Beri̇t Gökçe Ceylan, Lütfi̇ Yavuz, Füsun Eroğlu, Şenol Gülmen, Ömer Ridvan Tarhan, Adnan Alaca
Turkish Journal of Medical Sciences
As liver and kidney failure have a direct effect on mortality, morbidity, and intensive care unit (ICU) length of stay in sepsis patients, maintaining their functions or minimizing the degree of failure should be one of the most important goals of therapy. In this retrospective study we investigated the effects of recently introduced adjuvant therapies on hepatorenal functions in septic ICU patients. Materials and methods: We conducted comparative and retrospective data analysis of 108 patients with sepsis that were followed-up during a 2-year period in the ICU. We recorded AST, ALT, ALP, albumin, bilirubin, and INR in order to evaluate …
Levels Of Haemophilus Influenzae Type B (Hib) Antibody In Turkey Before Routine Immunization, Cemi̇le Sönmez, Ni̇lay Çöplü, Demet Kurtoğlu, Berri̇n Esen, Annette Crowley Luke, Lorraine Ransley, Ayşegül Gözalan
Levels Of Haemophilus Influenzae Type B (Hib) Antibody In Turkey Before Routine Immunization, Cemi̇le Sönmez, Ni̇lay Çöplü, Demet Kurtoğlu, Berri̇n Esen, Annette Crowley Luke, Lorraine Ransley, Ayşegül Gözalan
Turkish Journal of Medical Sciences
The Haemophilus influenzae type b (Hib) vaccine was introduced into the routine immunization schedule in Turkey on January 1, 2007. This study investigates the immunity to Hib prior to the introduction of the vaccine. Materials and methods: Serum samples were collected from healthy volunteers between the ages of 6 months and 50 + years of age, living in the area of 26 health centers in the Samsun, Antalya, and Diyarbakir provinces during 2000-2001. In total, 1713 sera were selected for this study, and the younger age groups were given priority (range 0-82). A commercial ELISA test was used to measure …
Is Oxidative Stress An Etiologic Factor In Idiopathic Male Infertility?, Ercan Yeni̇, Hali̇l Çi̇ftçi̇, Murat Savaş, Ayhan Veri̇t, Abdullah Taşkin
Is Oxidative Stress An Etiologic Factor In Idiopathic Male Infertility?, Ercan Yeni̇, Hali̇l Çi̇ftçi̇, Murat Savaş, Ayhan Veri̇t, Abdullah Taşkin
Turkish Journal of Medical Sciences
The total antioxidant capacity (TAC) and total peroxide (TP) levels in the blood and seminal plasma of idiopathic infertile patients were compared with those of fertile controls to determine the role of oxidative stress in the etiology of idiopathic male infertility. Material and methods: Thirty-two idiopathic infertile males and 30 healthy, married, age-matched control subjects were included in the study. TAC and TP levels were measured in the blood and seminal plasma, and sperm parameters were studied in both groups. Results: Sperm parameters were significantly impaired in the study group compared with the controls. Blood plasma TAC and TP levels …
Underlying Diseases Of Recurrent Pneumonia In Turkish Children*, Osman Özdemi̇r, Si̇nan Sari, Arzu Bakirtaş, Peli̇n Zorlu, Ülker Ertan
Underlying Diseases Of Recurrent Pneumonia In Turkish Children*, Osman Özdemi̇r, Si̇nan Sari, Arzu Bakirtaş, Peli̇n Zorlu, Ülker Ertan
Turkish Journal of Medical Sciences
The aim of the present study was to determine the relative frequency of recurrent pneumonia in children and to describe its underlying illnesses. Materials and methods: Children between 3 months and 16 years old who had a history of 2 or more episodes of pneumonia per year, or 3 or more episodes in a lifetime were investigated retrospectively at Doctor Sami Ulus Children's Training and Research Hospital between January 2002 and December 2004. Results: Out of 595 children admitted for pneumonia, 62 (10.42%) met the criteria for recurrent pneumonia. An underlying illness was demonstrated in 56 patients (90.32%). In this …
The Effects Of Adding Methylprednisolone To Low-Potassium Dextran Solution On Preserved Ischemic Lungs, Ali̇ Yegi̇nsu, Makbule Ergi̇n, Hüseyi̇n Özyurt, Çi̇ğdem Elmas, Güleser Çağlar Göktaş
The Effects Of Adding Methylprednisolone To Low-Potassium Dextran Solution On Preserved Ischemic Lungs, Ali̇ Yegi̇nsu, Makbule Ergi̇n, Hüseyi̇n Özyurt, Çi̇ğdem Elmas, Güleser Çağlar Göktaş
Turkish Journal of Medical Sciences
To investigate the effects of adding methylprednisolone to low-potassium dextran solution on cold-preserved ischemic lungs. Materials and methods: The study included 42 rat lung blocks that were divided into 7 groups (n = 6). Lung blocks were preserved in 40 mL of cold Perfadex solution, to which 5, 15, 30, 60, and 120 mg kg-1 (approximately 40, 120, 240, 480, and 960 mg L-1) of methylprednisolone were added. After a 24-h preservation period, the lungs were removed from the solution and examined. Results: As compared to the Perfadex only group, cell death and degeneration were significantly higher in the Perfadex …
Suitable Empiric Antibiotic Therapy Saves Life In Nosocomial Pneumonia Caused By Stenotrophomonas Maltophilia, Gürdal Yilmaz, Savaş Özsu, İfti̇har Köksal, Tevfi̇k Özlü
Suitable Empiric Antibiotic Therapy Saves Life In Nosocomial Pneumonia Caused By Stenotrophomonas Maltophilia, Gürdal Yilmaz, Savaş Özsu, İfti̇har Köksal, Tevfi̇k Özlü
Turkish Journal of Medical Sciences
Stenotrophomonas maltophilia is a nosocomial pathogen of increasing importance. Empiric antibiotic therapy for S. maltophilia infection is difficult because the microorganism is resistant to a number of agents typically used for health care associated infections, thus potentially increasing mortality. This study investigates 23 nosocomial pneumonia cases caused by S. maltophilia, the antibacterial sensitivity of the bacterium and the effect on mortality of suitable empiric therapy. Materials and methods: Twenty-three patients with nosocomial pneumonia caused by S. maltophilia between January 2000 and December 2006 at the Karadeniz Technical University Hospital were retrospectively investigated. Results: Suitable empiric therapy was used with 12 …
Nitric Oxide And Trace Metals In Relation To Haemoglobin F Concentration In Nigerian Sickle Cell Disease Patients, John Ayodele Olaniyi, Olatubosun Ganiyu Arinola
Nitric Oxide And Trace Metals In Relation To Haemoglobin F Concentration In Nigerian Sickle Cell Disease Patients, John Ayodele Olaniyi, Olatubosun Ganiyu Arinola
Turkish Journal of Medical Sciences
Sickle cell disease (SCD) is an inherited haemoglobin (Hb) disorder associated with vaso-occlusive events, oxidative stress, high energy demand, and endothelial dysfunction. The endothelium plays a central role in the regulation of vascular homeostasis by releasing nitric oxide (NO) among other factors. Therefore, the objective of this study was to measure plasma levels of NO, trace metals, and HbF in SCD patients. Materials and methods: Plasma levels of NO, Zn, Mg, Mn, Se, Cu, Fe, Haemoglobin F (HbF) were measured in 59 steady state SCD patients referred to the Department of Haematology, University College Hospital, Ibadan, Nigeria and 35 age/sex …
Tetanus In An Intensive Care Unit Of A Turkish Hospital: Patient Analysis Of A 6-Year Period, Behi̇ce Kurtaran, Emre Karakoç, Aslihan Candevi̇r, Süheyla Kömür, Ayşe Seza İnal, Fi̇li̇z Ki̇bar, Yeşi̇m Taşova, Neşe Saltoğlu, Hasan Sali̇h Zeki̇ Aksu
Tetanus In An Intensive Care Unit Of A Turkish Hospital: Patient Analysis Of A 6-Year Period, Behi̇ce Kurtaran, Emre Karakoç, Aslihan Candevi̇r, Süheyla Kömür, Ayşe Seza İnal, Fi̇li̇z Ki̇bar, Yeşi̇m Taşova, Neşe Saltoğlu, Hasan Sali̇h Zeki̇ Aksu
Turkish Journal of Medical Sciences
To retrospectively evaluate the clinical features of patients admitted to the medical intensive care unit (ICU) of our hospital between January 2001 and May 2007 due to tetanus. Materials and methods: Patient vaccination history, incubation period, nosocomial infections, noninfectious conditions, mortality, and length of stay in the ICU and hospital were documented. Results: Fifteen tetanus patients were admitted during the 6-year period. Mean age of the patients (9 male, 6 female) was 60 ± 13 years. Median length of stay was 42 days (range: 30-77 days) for survivors and 7 days (range: 1-59 days) for non-survivors. Mortality was consequent to …
Comparative Evaluation Of The Antifungal Susceptibility Of Candida Isolates From Blood Specimens: Results Of A Study In A Tertiary Care Hospital In Bursa, Turkey, Canan Evci̇, Beyza Ener, Güher Göral, Sevi̇m Akçağlar
Comparative Evaluation Of The Antifungal Susceptibility Of Candida Isolates From Blood Specimens: Results Of A Study In A Tertiary Care Hospital In Bursa, Turkey, Canan Evci̇, Beyza Ener, Güher Göral, Sevi̇m Akçağlar
Turkish Journal of Medical Sciences
Antifungal susceptibility testing may be an important aid in the treatment of patients with life threatening yeast infections. The aim of this study was to determine the susceptibility of Candida isolates obtained from clinical specimens to the antifungal agents amphotericin B and fluconazole, which are frequently used in our clinical practice. Materials and methods: Susceptibility to antifungal agents was investigated using the Etest (AB Biodisk, Solna, Sweden) and the reference broth macrodilution susceptibility test (CLSI M27-A2). The MICs obtained with each of the methods were read after 24 h and 48 h of incubation. Results: Overall agreement rates within ±1 …
Effect Of L-Carnitine On Diabetic Neuropathy And Ventricular Dispersion In Patients With Diabetes Mellitus, Hizir Ulvi̇, Recep Aygül, Recep Demi̇r
Effect Of L-Carnitine On Diabetic Neuropathy And Ventricular Dispersion In Patients With Diabetes Mellitus, Hizir Ulvi̇, Recep Aygül, Recep Demi̇r
Turkish Journal of Medical Sciences
Diabetes is a common cause of polyneuropathy. Cardiac arrhythmias and markedly increased mortality rate have been demonstrated in patients with diabetic neuropathy and also demonstrated that abnormally prolonged QT dispersion interval (QTd) is associated with a higher risk of ventricular arrhythmias and sudden death. We investigated the efficacy and tolerability of L-carnitine (LC) in the treatment of diabetic neuropathy and ventricular dispersion, mainly by evaluating the effects of treatment on electrophysiological parameters. Materials and methods: We recruited 30 patients with type I or type II diabetes (mean age: 60 ± 9 years, range: 36-75; 18 males, 12 females) meeting clinical …
Expression Of Ck-19, Cerbb2, Galectin-3, And P53 In Papillary Thyroid Carcinomas, Selda Seçki̇n, Ülker Karagece
Expression Of Ck-19, Cerbb2, Galectin-3, And P53 In Papillary Thyroid Carcinomas, Selda Seçki̇n, Ülker Karagece
Turkish Journal of Medical Sciences
To determine the immunohistochemical expression of CK-19, cErbB2, galectin-3, and p53 in papillary thyroid carcinomas (PTC). Materials and methods: In this study immunohistochemistry was performed on 23 papillary carcinomas (PCs) and 20 papillary microcarcinomas (PMCs). The extents of staining and intensity were scored semiquantitatively. Results: Of the PC cases 56.5% and of the PMC cases 15.0% were stained strongly by cErbB2. The extent of 2+ staining by galectin-3 was 47.8% in PC, whereas it was only 10.0% in PMC (P = 0.003). All PMC cases were stained by CK-19 and 21 cases of PC expressed positivity in varying extent of …
Effect Of Telmisartan On Vascular Endothelium In Hypertensive And Type 2 Diabetic Hypertensive Patients, Burcu Barutçuoğlu, Zuhal Parildar, M. Işil Mutaf, Di̇lek Özmen, Emi̇n Ali̇oğlu, Sara Habi̇f, Oya Bayindir
Effect Of Telmisartan On Vascular Endothelium In Hypertensive And Type 2 Diabetic Hypertensive Patients, Burcu Barutçuoğlu, Zuhal Parildar, M. Işil Mutaf, Di̇lek Özmen, Emi̇n Ali̇oğlu, Sara Habi̇f, Oya Bayindir
Turkish Journal of Medical Sciences
Hypertension and type 2 diabetes mellitus (DM) cause endothelial dysfunction and may result in cardiovascular disease. The aim of this study was to assess endothelial dysfunction in essential hypertensives, and normotensive and hypertensive type 2 diabetics and to evaluate the effect of telmisartan on endothelium in hypertensives. Materials and methods: Eighteen essential hypertensives (group 1), 16 type 2 diabetic hypertensives (group 2), 10 type 2 diabetic normotensives (group 3), and 10 control subjects (group 4) were included in this study. Groups 1 and 2 received 40 mg/day telmisartan for 12 weeks and were evaluated at the beginning and end. Groups …