Medicine and Health Sciences Commons^™

Organellar Zn2+ Homeostasis And The Role Of Trpml Channels In Neuronal Lysosome Physiology And Axonal Transport, Taylor Franklin Minckley

Electronic Theses and Dissertations

Zinc (Zn²⁺) is crucial for proper cellular function, and as such it is important to measure and track Zn²⁺ dynamics in living cells. Fluorescent sensors have been used to estimate Zn²⁺ content of subcellular compartments, but little is known about endolysosomal Zn2+ homeostasis. Similarly, although numerous sensors have been reported, it is unclear whether and how Zn²⁺ can be released from intracellular compartments into the cytosol due to a lack of probes that can detect physiological dynamics of cytosolic Zn²⁺. My dissertation started with comparing and characterizing different Zn²⁺ sensors including the …

Exploring The Relationship Between Historical Redlining And Place-Based Reproductive Health Inequities: A Qualitative Gis Approach, Kristi L. Roybal

Electronic Theses and Dissertations

Individual-level risk factors and characteristics do not fully explain racial, ethnic, and socioeconomic inequities in preterm birth in the United States, and evidence suggests that medical advancements, increased access to prenatal care, and high per-capita spending on health care have done little to reduce these inequities. Health inequities research has shifted its attention from individual-level factors that influence health outcomes to the social determinants of health. Neighborhoods, considered an important upstream social determinant of health, can influence health outcomes through their social, service, and physical environments, and have been consistently linked to birth outcomes. Despite increased attention to neighborhood influences …

Well-Being Development: Parents’ Perceptions Of Gifted Adolescents, Barbara Moncure Washington

Electronic Theses and Dissertations

The purpose of this study was to examine parents’ perceptions of well-being development in their gifted adolescents. This was a qualitative study that used Narrative Inquiry as a research approach. Cloninger’s (1993) Psychobiological Model of Temperament and Character the (TCI) and Clandinin and Connelley’s (2000) Three-Dimensional Narrative Inquiry Space were utilized to address the research questions: What are parents’ perceptions of temperament in their gifted adolescent? What are parents’ perceptions of character in their gifted adolescent? What are the parents’ perceptions of well-being development? Dabrowski’s Theory of Positive Disintegration (TPD) provided an analysis lens for the study.

The framework for …

Mitigating Weight Stigma In The Medical System: Self-Compassion For Nursing Students, Ellen C. Joseph

Electronic Theses and Dissertations

Weight stigma is a form of oppression that has been shown to have a detrimental impact on the well-being of people with higher weight. Healthcare providers are one of the most common sources of weight stigma, and their stigmatizing beliefs have been found to be associated with differential care for patients with “obesity”. The current study aimed to explore the feasibility of the loving-kindness meditation (LKM) as a brief intervention that reduces weight bias in nursing students by increasing self-compassion, positive, other-focused emotions, and cognitive flexibility, in order to improve compassionate care for patients with higher weight. Participants (189 nursing …

Antioxidant Biomarkers And Nutraceutical Therapeutics In Neurodegeneration And Neurotrauma, Lilia A. Koza

Electronic Theses and Dissertations

Mild traumatic brain injury (mTBI), yielding a Glascow Coma Scale of 13-15, is the most commonly occurring severity of TBI. Pathology from mTBI consists of blood brain barrier disruption, neuroinflammation, oxidative stress, excitotoxicity, mitochondrial dysfunction, protein aggregation, axonal degeneration, and resulting neuronal death. These processes deplete the body’s endogenous antioxidant system. We report a retrospective analysis of antioxidant blood biomarkers in patients with a history of mTBI from a local sports medicine clinic, Resilience Code. We found persistent sex-specific antioxidant depletions in mTBI patients associated with worsened symptomology.

Certain populations, such as athletes, are at high risk for repetitive mTBI …

Decoding The Mystery Of Antibiotic Persistence, Tahmina Hossain

Electronic Theses and Dissertations

This work combines microbiology, molecular biology, Next-Generation Sequencing and system biology approaches to explore the mechanism of antibiotic persistence: a multi-drug tolerant, non-dividing, and metabolically altered state present in a subpopulation of cells due to phenotypic diversity rather than genetic variation (i.e. mutations). Persister can survive lethal antibiotic state and resuscitate after the treatment period is over. They are considered as the major contributing factor behind recurring infections. They also have a high mutation rate, which increases the chances of bacteria gaining antibiotic resistance. The formation of this phenotypic variant (persister) threatens the therapeutic effectiveness of antibiotics and understanding how …

Emerging Respiratory Viral Pathogens, April Nelsen

Electronic Theses and Dissertations

Respiratory disease is arguably the most important health concern for the production animal industry [1-3]. Respiratory problems accounted for the highest mortality both in the swine and beef industries [1, 4]. Respiratory pathogens remain the most vital for swine and bovine research and disease monitoring [2, 5-7]. As pathogens, in particular viral pathogens, mutate, novel disease-causing viruses emerge, and there becomes an increasing concern and need for identification with control perimeters. One frequently identified disease syndrome is Porcine Respiratory Disease Complex (PRDC). PRDC is characterized by pneumonia of mixed respiratory infections with contributions from the environment and management practices. The …

Effectiveness Of Telemedicine In Diabetes Management: A Retrospective Study In An Urban Medically Underserved Population Area (Umupa)., Lisa Ariellah Ward

Electronic Theses and Dissertations

The purpose of this research is to assess the efficacy of employing telemedicine (TM) technology compared to traditional face-to-face (F2F) visits as an alternative healthcare delivery service for managing diabetes in populations residing in urban medically underserved areas (UMUPA). Researchers investigating public health and healthcare systems fully grasp the enormous challenges encountered by vulnerable populations as a result of healthcare access barriers.¹ Prior to the COVID-19 pandemic, F2F visits were most often utilized for healthcare delivery service, which frequently posed barriers for vulnerable populations. When marginalized people, encounter healthcare access barriers, a cascade of events generally occur leading to …

Genistein-Enriched Pig Gut Microbiota Library As A Potential Probiotic Consortium, Theresah Amponsah

Electronic Theses and Dissertations

Plant-based diets contain numerous flavonoid compounds that produce antibacterial effects and gut health improvement. Genistein is among the most abundant isoflavones present in a plant-based diet and can be found in high amounts in soy products (up to 1g Kg-1). We describe here a robust method to identify genistein tolerant and metabolizing bacteria in swine gut microbiota and to screen the strains that have antibacterial and immunestimulatory properties. Such strains could be developed as non-antibiotic alternatives to prevent enteric infections in pigs and improve gut immunity. To this end, a mini bioreactorbased system was used to enrich genistein metabolizing bacteria …

Polymeric Nanovaccine Delivery System For Influenza Vaccine, Chaitanya K. Valiveti

Electronic Theses and Dissertations

Vaccines are the most efficient and cost-effective method for preventing illnesses caused by infectious pathogens. Even though the great success of vaccines over decades, the development of safe and robust vaccines is still essential for emerging new pathogens, re-evolving old pathogens, and improving the insufficient protection given by existing vaccines. One of the most critical strategies for developing effective new vaccines is selecting and using a suitable adjuvant or immune stimulant. Immunologic adjuvants are essential for improving vaccine potency by enhancing the immune response of vaccine antigens. The amount of antigen could be spared with improved potency, especially during mass …

Role Of Host Restriction Factors On Porcine Reproductive And Respiratory Syndrome Virus (Prrsv) Replication, Pratik Katwal

Electronic Theses and Dissertations

In this study, the role of IFITM3 on PRRSV replication was studied in vitro by expressing exogenous IFITM3 in MARC-145 cells. An average of 31% reduction in PRRSV N protein expression and an average of 5.4 fold decrease in virus titer in the supernatant were observed in IFITM3 overexpressing cells as compared to vector control cells at 24 hours post infection (hpi). Moreover, there was a positive correlation between interferon- induced IFITM3 up-regulation and reduced PRRSV replication. To determine the role of endogenous IFITM3 in PRRSV replication, siRNA induced knockdown of IFITM3 was employed. RT-PCR validated the successful silencing of …

Factors Associated With Increased Breastfeeding At Initiation And Continuation At Two Months In American Indian Women, Addison Reimer

Electronic Theses and Dissertations

Introduction: The purpose of this report was to determine the prevalence of breastfeeding at initiation and two months continuation in American Indian South Dakota mothers who gave birth between 2017-2019 and determine the factors associated with breastfeeding and various health behaviors and beliefs. This study serves to fill the current gaps in research focusing on breastfeeding in American Indian women in South Dakota. Methods: Data from the South Dakota Pregnancy Risk Assessment Monitoring System (SD PRAMS), a state-based surveillance system, was used to investigate the relationship between breastfeeding and maternal behaviors, attitudes, and experiences. Logistic regression was used to determine …

Immune-Related Adverse Events Of Immune Checkpoint Inhibitors: Incidence, Risk Factors, Clinical Outcomes, And Economic Burden In Older Adults With Non-Small Cell Lung Cancer, Yiran Rong

Electronic Theses and Dissertations

To fill the gap in existing literature related to immune-related adverse events (irAEs) induced by immune checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC), this dissertation focused on: 1) assessing the incidence, spectrum and risk factors for the development of irAEs; 2) assessing the clinical impact of irAE occurrence on survival and treatment discontinuation; 3) analyzing and estimating the incremental economic burden of irAEs among an older population in the United States (US). A retrospective cohort study was conducted using the SEER-Medicare 2020 linkage database in order to evaluate the three study objectives. The dissertation included 8,175 patients diagnosed …

Barriers To Musculoskeletal Injury Reporting In High School Athletes: A Qualitative Study, Mikayla Talak

Electronic Theses and Dissertations

INTRODUCTION: There are a substantial amount of sport related injuries recorded at the high school age and it has been recorded as a public health concern in a vast amount of health literature. Although participating in sports has a risk of injury associated with it, it is common for high school athletes to underreport injuries. But there is no known literature on injury reporting behaviors of musculoskeletal injuries in the high school athletic population. Therefore, the purpose of this study is to explore the barriers and facilitators to musculoskeletal injury reporting and towards playing injured in athletes that attend a …

Sexual Minority Stress And Mental Health: An Investigation Of Rural-Urban Differences In Social Support, Justin T. Miller

Electronic Theses and Dissertations

As mental health disparities and discrimination facing the LGB (sexual minority) community continues to come into public focus, researchers and clinicians are moving toward identifying LGB-specific mental health interventions to support well-being efforts within this population. Furthermore, much of the current literature on sexual minority mental health is focused on predominantly urban samples failing to consider the sociocultural impacts of living in low resourced and geographically isolated regions of the United States (US). To this end, social support is a promising prevention factor, but few studies to date examine its influence on different minority stress models. As such, the current …

Becoming A Public Health Professional: Millennials’ Perspective On Organizational Assimilation And Professional Identity, Tony K. Winters

Electronic Theses and Dissertations

ABSTRACT

Public health must confront the ongoing challenge of workforce transitions and the impending exodus of existing employees. The millennial generation rises as an option to fill this workforce gap. Using the Socialization Resource Theory as a framework and qualitative data from in-depth interviews with 27 millennial professionals from federal, state, local, and non-governmental public health agencies, this study describes (a) the organizational assimilation (OA) process for millennial public health professionals, (b) explores the impact of OA on professional identity, and (c) describes how the OA process may impact the retention of public health professionals.

The results from this study …

Factors Associated With Intention To Disclose Concussive Symptoms In Active Duty Soldiers, Carly Beck

Electronic Theses and Dissertations

Background: Concussion disclosure is a heavily researched topic, and while previous literature has explored predictors of concussion disclosure in numerous populations, research within the active duty Soldier population is limited. This study further explored predictors of concussion disclosure to a medical professional or leadership in the active duty Solider population through the lens of the Theory of Planned Behavior. Methods: A cross-sectional electronic survey was distributed to 181 active duty Soldiers. Descriptive statistics were used to report frequency of high intention to disclose concussive symptoms among demographics, and a multivariate regression model was used to assess significant predictors of intention …

Exploring Sport, Exercise, And Performance Psychology Practitioners’ Attitudes On Attire, Claire Harding

Electronic Theses and Dissertations

Research has revealed that attire has an influence on one’s self-perceptions, self and socially prescribed adjective traits and behavior (Adam & Galinsky, 2012; Lubker et. al, 2008; Peluchette & Karl, 2007). The present study aims to explore the influence of attire on perceptions, attitudes, and experiences of SEPP (Sport, Exercise, and Performance Psychology) practitioners during their applied work. Specifically, these factors were investigated through various demographic lenses such as gender, experience level, and age in order to describe the population. SEPP graduate students (n = 49) and early career professionals (n = 82) were asked to participate in a questionnaire, …

Experiences And Perceptions Of Female Athletic Trainers Working With Male Coaches In Male Sports, Sierra Hobday

Electronic Theses and Dissertations

Context: Female athletic trainers are making great strides in a previously male-dominated profession and are also becoming more prevalent in working with male sports teams. Female athletic trainers working within male sports often face gender bias and discrimination which has been found to come from male coaches of these sports. While previous studies have shown male coaches may demonstrate practices of gender bias towards female athletic trainers working in male sports, no studies have focused directly on the male coach and female athletic trainer relationship. Purpose: To examine the experiences and perceptions of female athletic trainers currently working with male …

Characteristics And Regions Of Hospital Locations And The Risk Of Postpartum Hemorrhage., Zahra Shahin

Electronic Theses and Dissertations

Background: Postpartum hemorrhage (PPH) is one of the contributing factors to maternal morbidity and mortality that in addition to maternal risk factors, may be related to other factors such as obstetric practice and clinical management of postpartum hemorrhage. Therefore, this study aimed to explore the association of postpartum hemorrhage with characteristics and regions of hospital locations across the United States, as the outcomes may create opportunities to improve policies and protocols regarding PPH management more effectively. Method: A retrospective study was performed using the 2018 National Inpatient Sample (NIS) database. Low-risk delivery hospitalizations involving the third stage of labor with …

The Tragedy Of Caspian: C. S. Lewis And His Trauma, Chandler Hanton

Electronic Theses and Dissertations

This thesis reconsiders C.S.Lewis’ The Chronicles of Narnia as a type of scriptotherapy that enabled Lewis to process and come to terms with a life full of serious and significant traumatic events. Trauma theory offers a vehicle for us to consider the alignments and connections between Lewis himself and his fictional creation, Caspian. In the specifics of both characterization and incident, Lewis mirrors the events and relationships that instilled and healed the trauma in his own life. In situating Caspian as his alter-ego, Lewis allowed his writing to function as a gender-specific therapeutic process for addressing the effects of his …

Stress, Stress Appraisal And Coping In Athletic Trainers During The Covid-19 Pandemic, Lawson Holton

Electronic Theses and Dissertations

Introduction: There have been many studies conducted on the stress and mental health of frontline healthcare workers (HCWs) over the past months since the COVID-19 pandemic began. Very limited literature has examined the effect of the pandemic on athletic trainers (ATs). Objective: The aim of this investigation was to examine the stress, stress appraisal, and coping measures of ATs during the COVID-19 pandemic. Methods: Participants were recruited members from the National Athletic Trainers’ Association (NATA). The Perceived Stress Scale-10 was used to measure stress, the Stress Appraisal Measure was used to measure stress appraisal, and the Brief COPE was used …

The Relationships Between Sleep Quality, Health-Related Quality Of Life, And Injury In High School Student Athletes, Karleigh Kirsch

Electronic Theses and Dissertations

Various physiological and lifestyle factors make shorter sleep durations more prevalent in young people, leaving them at risk of sleep deprivation. In addition to overall poorer health outcomes and decreases in well-being, lack of sleep has known effects on performance, neurocognitive functioning, and recovery from exercise. This creates a greater potential for sport-related injury to occur. The purpose of this study was to investigate the relationships between sleep quality, health-related quality of life, and injury in high school student athletes. The sample consisted of 100 high school athletes (M age = 15.86, SD = 1.25 years). Participants completed a …

Does Race Have An Influence On The Athletic Trainer-Coach Relationship, Cayce M. Sloan

Electronic Theses and Dissertations

Introduction: Interpersonal relationships are the most frequent types of relationships individuals maintain on a daily basis. Rapport provides the foundation necessary to build positive interpersonal relationships, specifically, collegial relationships such as the relationship between the athletic trainer and coach. However, facilitators and barriers exist that may hinder relationships. Specifically, race appears to influence relationships, but to date, it appears race has not been examined in the athletic trainer-coach relationship. Therefore, the purpose of this study was to examine the facilitators and barriers to building rapport in race-discordant athletic trainer-coach relationships and to examine the role race plays within the athletic …

A Virtual Camp For Adolescents With Developmental Disabilities During The Covid-19 Pandemic: Changes In Physical Activity, Function, And Psychosocial Health, Sarah Creveling

Electronic Theses and Dissertations

Adolescents with developmental disabilities (DD) have low levels of physical activity (PA), are more likely to be overweight or obese, and are at an increased risk of developing secondary conditions compared to their typically developing peers. Participation in PA has been linked to a myriad of benefits including improvements in psychosocial health, decreased risk of developing secondary conditions, and opportunities for socialization. Summer camps provide opportunities for adolescents with DD to participate in meaningful activities while being physically active during the summer months when school is out and there is a change in routines, skill and learning loss is a …

Effects Of Various Golf Bag Loading Strategies On Perceived Exertion And Vertical Jump Performance, Austen Arnold

Electronic Theses and Dissertations

INTRODUCTION: The sport of golf is increasing in popularity among both novice and skilled players alike. A round of golf necessitates players to cope with a range of physically demanding movement patterns. At the collegiate level, golfers must transport their clubs by loading them onto the body. Previous literature has yet to determine how different golf bag carrying positions influence periodic, unloaded jump performance and perceived exertion of the load carrying task. PURPOSE: The purpose of this study is to investigate how different golf bag load carriage methods may influence vertical jump performance and perceived exertion. METHODS: Five golf bag …

Correlates Of Risky Sexual Behaviors Among African American Females In Juvenile Detention Centers, Eghosa E. Asemota

Electronic Theses and Dissertations

Introduction: In comparison to other demographics, research shows that African American female adolescents are over-represented in the United States Juvenile Justice System. Studies in this vulnerable population demonstrate higher rates of engagement in unsafe sex, and its attendant negative consequences of HIV infections, sexually transmitted diseases, and mistimed pregnancies. There is a paucity of studies that have specifically examined risky sexual behaviors amongst African American females in Juvenile Detention Centers. Objective: The aim of this study is to assess the relationship between the individual, family, peer, and societal factors, and engagement in risky sex among Black female detainees in Juvenile …

Seasonal Variation In Anthropometric And Performance Variables In American Professional Soccer Players, Hannah Elizabeth Ramirez

Electronic Theses and Dissertations

BACKGROUND: Preseason is an essential component of sport; it prepares players physiologically for the beginning of the competitive season by allowing for improvements in performance and fitness variables. As the season progresses, the need to maintain an ideal performance state may be difficult due to accumulating training load. PURPOSE: The purpose was to determine the seasonal variation of power, agility, and body fat percentage (BF%) via a series of tests throughout the competitive season of American professional soccer players. METHODS: 23 male United Soccer League (USL) One players underwent a performance battery (akimbo vertical jump (VJ), reactive strength index (RSI), …

Exploring Bscn Recent Graduates’ Perceived Readiness To Practice, Robyn Marie Lapuz

Electronic Theses and Dissertations

Assessing BScN recent graduates and their readiness to practice is of vital importance in the climate of high nursing turnover and nursing migration. The literature confirms that readiness to practice is a longstanding issue in nursing and the practice-education gap remains an issue to date. The purpose of this research was to explore BScN recent graduates’ perceived readiness to practice in nursing and make recommendations for nursing practice, education, and future research. A cross-sectional descriptive correlational mixed-methods research design was used for this research. The results confirm that the majority of BScN recent graduates from this study reported feeling ready …

The Experience Of Transitioning For The Transgender Person: An Appreciative Inquiry Approach To Advance Gender Affirming Care, Shelley Evans

Electronic Theses and Dissertations

Background. The process of transitioning has a significant impact on improving quality of life among transgender and nonbinary people (Johansson et al., 2010). Transitioning is the act of moving towards a gender identity that feels more aligned with internal identity (Rankin & Beemyn, 2012). However, despite promising research that supports the benefits of medical, social and/or legal transitioning, the understanding of the experience has not been fully explored (Evans et al., 2021), and it is a barrier to advancing the delivery of gender affirming care among nurses, other health care providers, and health care organizations. There is a need to …