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Articles 781 - 810 of 828
Full-Text Articles in Medicine and Health Sciences
Editorial: Responsibilities Of Scientists--A Closer Look, Fairfield Goodale Jr.
Editorial: Responsibilities Of Scientists--A Closer Look, Fairfield Goodale Jr.
MCV/Q, Medical College of Virginia Quarterly
From a reading of today's lay and scientific press, one must conclude that scientists are most important people. And, indeed, the signs of their beneficence are on every hand--rapid travel, instant communication, globe-encircling rockets, moon probes, food surpluses, longer life spans, and all manner of creature comforts which by now are taken for granted. Verily, ours is the age of scientific marvels and we are in the debt of those who have made it possible.
The Shame Of American Medicine, Elinor Langer
The Shame Of American Medicine, Elinor Langer
MCV/Q, Medical College of Virginia Quarterly
The success of American medicine is often attributed to the profession's ability to serve the public on its own terms. Why should doctors care if, from the patient's point of view, the terms chosen--solo practice and emphasis on the "doctor-patient relationship"--mean that a doctor performs unsupervised services for unregulated fees? What does it matter to them that the poor are outside the system altogether, treated in charity wards or public hospitals which are the medical equivalent of Andrew Carnegie's libraries, a small concession to charity from an accelerating machine of wealth, power, and influence? In a country proud of its …
"Slow" And "Fast" Muscle Fibers, Ernest Gutmann
"Slow" And "Fast" Muscle Fibers, Ernest Gutmann
MCV/Q, Medical College of Virginia Quarterly
On the basis of the clear-cut differentiation used in fast (twitch) and slow (tonic) muscles of the frog, both the fast E.D.L. and the slow soleus muscle should be considered twitch muscles. However, they reveal a marked differential behavior in their contracture responses to ACh and caffeine. Moreover, all the slow muscles I have studied (i.e.. the L.D.A. of the chicken, the rectus abdominis of the frog, and the soleus of the rat) show a higher rate of proteosynthesis. This may be related to the basic function of slow muscles concerned with long-lasting maintenance of tension, the extreme being, for …
Contents
MCV/Q, Medical College of Virginia Quarterly
Table of contents for MCV/Q, Medical College of Virginia Quarterly, Spring 1966, Volume Two, Number One.
Contents And Editorial
MCV/Q, Medical College of Virginia Quarterly
Table of contents for MCV/Q, Medical College of Virginia Quarterly, Spring 1965, Volume One, Number One.
Electron Microscopic Observations Of Human Leucocytes: Ii. Appearance In Naturally Occurring Fevers, Fairfield Goodale Jr., Elizabeth A. Hillman, Ralston Fillmore
Electron Microscopic Observations Of Human Leucocytes: Ii. Appearance In Naturally Occurring Fevers, Fairfield Goodale Jr., Elizabeth A. Hillman, Ralston Fillmore
MCV/Q, Medical College of Virginia Quarterly
When human leucocytes are artificially stimulated in vivo or in vitro by a bacterial pyrogen, they release, without destroying themselves, a pyrogenic substance that differs chemically and biologically from the original bacterial pyrogen (Snell et al., 1956; Cranston et al., 1956). Although leucocytic pyrogen has not been seen, or at least recognized, by light or phase microscope, a finely granular extracellular material is consistently visible by electron microscope in artificially stimulated leucocyte preparations that we know to be pyrogenic (Goodale, Fillmore, and Hillman, 1962). We are reasonably certain that the granular material is a genuine cellular product in response to …
On The Mathematical Basis Of Medical Diagnosis, Malcolm E. Turner
On The Mathematical Basis Of Medical Diagnosis, Malcolm E. Turner
MCV/Q, Medical College of Virginia Quarterly
Armed with an overwhelming accumulation of data about disease, how can we ensure that they will all be employed effectively to make a correct diagnosis in a particular patient? The use of electronic computers can be of some help in the collation, correlation, storage, and communication of the accumulated information, but we must be careful in instructing the machinery so we will not one day find a monster whose behavior is unpredictable. A reasonable procedure would be to analyse our own thought processes carefully to ascertain how the human diagnostician arrives at his conclusions. The matter is certainly not settled …
Energy Requirements Of Breathing, W. T. Thompson Jr.
Energy Requirements Of Breathing, W. T. Thompson Jr.
MCV/Q, Medical College of Virginia Quarterly
The mass movement of gases into and out of the lungs is accomplished by muscular work. This requires energy expenditure, caloric consumption, oxygen utilization, and carbon dioxide production. Inspiration is always an active process, enlarging the volume of the thorax, thereby increasing the negative pressure so that air flows into the lungs. Expiration is ordinarily passive but may require muscular work.
Contents
MCV/Q, Medical College of Virginia Quarterly
Table of contents for MCV/Q, Medical College of Virginia Quarterly, Summer 1965, Volume One, Number Two.
The Need For Change In Medical Education, Fairfield Goodale Jr.
The Need For Change In Medical Education, Fairfield Goodale Jr.
MCV/Q, Medical College of Virginia Quarterly
The key to tomorrow's medical practice lies, not in the development of better clinical artisans, but in the development of clinicians who can interpret disease through application of the basic sciences. A medical curriculum at a graduate student level, based on patient-centered teaching with strong and continuous basic science correlation, could provide such clinician-scientists.
An Approach To Medical Education: The Medical College Of Virginia School Of Medicine Curriculum, Edwin F. Rosinski
An Approach To Medical Education: The Medical College Of Virginia School Of Medicine Curriculum, Edwin F. Rosinski
MCV/Q, Medical College of Virginia Quarterly
After a relatively long interval in which the status quo was maintained, in the early 1950's American medical schools began to reappraise their educational programs. Many shortcomings of medical education which now have been corrected were cited as early as 1946. The Medical College of Virginia began a detailed study of its educational program. A curriculum has been designed and initiated, using the subject matter committee approach. The curriculum provides opportunity for electives, research, and free time. In conjunction with the revised curriculum, changes in grading procedures, examinations, and teaching methods have been made. A study to assess the effects …
Physiological Basis Of The Radioisotope Renogram, Louis D. Homer, Hermes A. Kontos, Joseph Magee, Malcolm E. Turner, James Oates Iii, Alton Sharpe Jr.
Physiological Basis Of The Radioisotope Renogram, Louis D. Homer, Hermes A. Kontos, Joseph Magee, Malcolm E. Turner, James Oates Iii, Alton Sharpe Jr.
MCV/Q, Medical College of Virginia Quarterly
A model elucidating the relationships between blood radioactivity, the renogram curve, and urine radioactivity, as a function of time, is derived. Estimation procedures have been devised which use the data from three curves at once to estimate parameters common to the three curves, and which also estimate parameters unique to the individual curves. A program has been written for the RPC 4000 computer to perform the estimation. It was found that some model in which six different exponential parameters could be justified instead of the two proposed by the model could provide a significantly better fit of the data (P < .001), but that the fit under the hypothesis was still quite good.
Treatment Of Hypertension, Edward D. Freis
Treatment Of Hypertension, Edward D. Freis
MCV/Q, Medical College of Virginia Quarterly
Our ideas about the management of hypertension have changed considerably in recent years. There is now general agreement that all patients with accelerated hypertension, as manifested by high diastolic pressure and Group III and IV funduscopic changes, should have their blood pressure reduced with antihypertensive agents. Differences of opinion still exist, however, in respect to the treatment of the less rapidly advancing types of hypertension. It is apparent that the life history of untreated essential hypertension varies widely from those patients whose lives are cut short in a matter of a few years, to those who survive to old age. …
Clinical Hemodynamics And Pharmacodynamics Of Toxemia, Frank A. Finnerty Jr.
Clinical Hemodynamics And Pharmacodynamics Of Toxemia, Frank A. Finnerty Jr.
MCV/Q, Medical College of Virginia Quarterly
For many years toxemia has served as a wastebasket for a variety of disease states characterized by an elevated arterial pressure, edema, and albuminuria. Whereas this triad is consistent with the diagnosis of toxemia, it is not diagnostic. Besides toxemia, these abnormalities may be found in pregnant patients with hypertensive vascular disease, pyelonephritis, glomerulonephritis, or any combination of these. Data derived from studies performed on patients with such a variety of disease entities have obviously been confusing. It makes a lot of difference, for example, whether the subjects studied had chronic pyelonephritis or acute vasospastic toxemia. During the past 13 …
Panel On Arteriosclerosis, William Dock
Panel On Arteriosclerosis, William Dock
MCV/Q, Medical College of Virginia Quarterly
Panel on Arteriosclerosis held during the Thirty-Sixth annual McGuire Symposium on Hypertension and Arteriosclerosis, Medical College of Virginia, October 7-9, 1964, moderated by William Dock.
Calender [I.E. Calendar] Of Postgraduate Education
Calender [I.E. Calendar] Of Postgraduate Education
MCV/Q, Medical College of Virginia Quarterly
Calendar of postgraduate education for the Medical College of Virginia, Fall 1965.
Mcv/Q, Medical College Of Virginia Quarterly, Vol. 1 No. 3
Mcv/Q, Medical College Of Virginia Quarterly, Vol. 1 No. 3
MCV/Q, Medical College of Virginia Quarterly
No abstract provided.
The Treatment Of Chronic Uremia, Belding H. Scribner
The Treatment Of Chronic Uremia, Belding H. Scribner
MCV/Q, Medical College of Virginia Quarterly
I will begin by telling a little about the development of chronic dialysis. In 1959 we were working on a system to prevent uremia in acute renal failure. We were trying to develop a system to which we could "hook" the patient for as long as a week, so that we would exactly mimic his normal kidney function during the period of acute renal failure, and make his prognosis that of a patient who had kidneys. The system worked reasonably well. We had to make a lot of modifications, such as using a Skeggs-Leonard dialyzer with low resistance. We used …
The Frequency And Natural History Of Urinary Tract Infection In School Children, Calvin M. Kunin
The Frequency And Natural History Of Urinary Tract Infection In School Children, Calvin M. Kunin
MCV/Q, Medical College of Virginia Quarterly
This presentation reviews briefly investigations of the epidemiology and natural history of urinary tract infections in school children conducted during the past four years in Central Virginia. The results of this work will be summarized and their implications discussed.
Mcv/Q, Medical College Of Virginia Quarterly, Vol. 1 No. 4
Mcv/Q, Medical College Of Virginia Quarterly, Vol. 1 No. 4
MCV/Q, Medical College of Virginia Quarterly
No abstract provided.
Oxygen Affinities And Electrophoretic Patterns Of Hemoglobins In Trout And Basses From Virginia, Jack D. Burke
Oxygen Affinities And Electrophoretic Patterns Of Hemoglobins In Trout And Basses From Virginia, Jack D. Burke
MCV/Q, Medical College of Virginia Quarterly
Hemoglobin solutions were prepared from pooled samples of blood taken from each of the following species; Salmo gairdneri, the rainbow trout; Salvelinus fontinalis, the brook trout; Salmo trutta, the brown trout; Micropterus dolomieui, the smallmouth bass; Micropterus salmoides, the largemouth bass. Hemoglobin electrophoretic patterns for each species were developed on cellulose acetate membranes. Oxyhemoglobin affinity curves were determined spectrophotometrically on different hemoglobin solutions from each species. Interspecific differences concerned with hemoglobin electrophoretic patterns, oxyhemoglobin affinities, and the Bohr effect were shown for both trout and basses.
Gastric Secretion Mediated By Extravagal Neural Influences, Charles H. Hockman, Ebbe C. Hoff
Gastric Secretion Mediated By Extravagal Neural Influences, Charles H. Hockman, Ebbe C. Hoff
MCV/Q, Medical College of Virginia Quarterly
In adult cats anesthetized with ether and immobilized with Flaxedil, the effects of electrical stimulation of cerebral loci on gastric secretion were studied. Stimulation of mesencephalic and diencephalic areas increased both the volume and acidity of samples collected hourly. Section of the spinal cord at the level of the second cervical vertebra abolished this secretion; however, subsequent stimulation in the lateral funiculus of the distal end of the severed cord elicited the response. These pilot studies present further evidence for extravagal mediation of gastric secretion.
Radiologic Diagnosis Of Congenital Heart Disease In Children, Richard G. Lester
Radiologic Diagnosis Of Congenital Heart Disease In Children, Richard G. Lester
MCV/Q, Medical College of Virginia Quarterly
The importance of precise anatomic and physiologic diagnosis in congenital heart disease has been emphasized in recent years, because of the increasing possibilities of surgical correction. The x-ray examination is a powerful tool in the evaluation of patients with congenital heart disease. A method of evaluation is presented, using conventional roentgenographic and fluoroscopic examination along with other simple clinical methods. This approach is relatively simple, can be carried out as an office procedure, and yields a firm clinical diagnosis in the majority of cases. Cardiac catheterization and selective angiocardiography may be necessary to give precise information on physiological abnormalities and …
Contributors To This Issue
MCV/Q, Medical College of Virginia Quarterly
List of contributors to this issue includes Alvan R. Feinstein, Frank A. Finnerty, Jr., Edward David Freis, Walter J. Geeraets, Alice C. Goodman, Louis Homer, A. John Honour, Hermes A. Kontos, Richard G. Lester, Joseph H. Magee, James Franklin Oates, III, Sir George White Pickering, David W. Richardson, Edwin F. Rosinski, Ralph M. Scott, Malcolm E. Turner, and Alton R. Sharpe, Jr.
The Effect Of Idoxuridine (Idu) On Corneal Stromal Cells In Tissue Culture, Walter J. Geeraets, Guy Wong, Dupont Guerry Iii
The Effect Of Idoxuridine (Idu) On Corneal Stromal Cells In Tissue Culture, Walter J. Geeraets, Guy Wong, Dupont Guerry Iii
MCV/Q, Medical College of Virginia Quarterly
Corneal stromal cells were cultured in vitro and exposed to various concentrations of idoxuridine (IDU), ranging from 0 to 1,000 μg of IDU per ml of medium. Inhibition of cell multiplication occurred with concentrations of 0.1 μg per ml. With concentrations of 1.0 μg per ml and greater, there was no increase in cell number from the time of exposure to IDU.
The Interdependence Of Pulmonary Structure And Function: A Synopsis, Norman C. Staub
The Interdependence Of Pulmonary Structure And Function: A Synopsis, Norman C. Staub
MCV/Q, Medical College of Virginia Quarterly
It is a great pleasure to participate in the 1964 Stoneburner lectures and to present some recent views on the structure and function of the lung. In this report I will give a brief summary and show you three pictures to indicate some of the inter-relationships that exist.
Central Nervous Control Of Blood Pressure In Man; Preliminary Report, David W. Richardson, A. J. Honour, A. C. Goodman
Central Nervous Control Of Blood Pressure In Man; Preliminary Report, David W. Richardson, A. J. Honour, A. C. Goodman
MCV/Q, Medical College of Virginia Quarterly
Electrical activity of the brain, eye movements, arterial pressure, heart rate, and respiratory rate and depth have been recorded continuously during a night of sleep not induced by drugs in 22 healthy subjects, two hypertensive patients, and one anephric man who was awaiting renal transplantation. Sleep was associated with reduction in arterial pressure averaging 50 mm Hg systolic and 30 mm Hg diastolic. Dreams, although occasionally associated with marked elevation of blood pressure, were usually accompanied by no change or a slight fall in pressure. The dramatic paroxysmal electroencephalographic alterations termed K complexes, occurring spontaneously or after a noise in …
Γ-Guanidinobutyric Acid: An Inhibitor Of Clot Formation And Of Clot Lysis, Phyllis S. Roberts
Γ-Guanidinobutyric Acid: An Inhibitor Of Clot Formation And Of Clot Lysis, Phyllis S. Roberts
MCV/Q, Medical College of Virginia Quarterly
During a study of the effects of a series of guanidine compounds on the esterolytic activities of thrombin, plasmin, and streptokinase plus plasmin or plasminogen, it was found that one of these compunds, γ-guanidinobutyric acid (GGBA), acted in several ways like ε-aminocaproic acid (EACA). Neither compound had any inhibiting effects on the rate of hydrolysis of TAMe (p-toluenesulfonyl-L-arginine methyl ester), but both inhibited the activation of plasminogen by streptokinase. EACA was the more potent inhibitor. Since EACA has been shown to inhibit the lysis of fibrin, primarily because it inhibits the activation of plasminogen (Ablondi et al., 1959, Alkjaersig, Fletcher, …
Panel On The Maintenance Of Life In Uremia, David M. Hume
Panel On The Maintenance Of Life In Uremia, David M. Hume
MCV/Q, Medical College of Virginia Quarterly
Panel on the Maintenance of Life in Uremia held at the Second Annual Kidney Symposium, Virginia Chapter of the National Kidney Disease Foundation, Richmond, October 16, 1964. Moderated by David M. Hume.
Pulmonary Surfactant And Its Relation To Disease, Sami I. Said
Pulmonary Surfactant And Its Relation To Disease, Sami I. Said
MCV/Q, Medical College of Virginia Quarterly
Perhaps the most important advance in respiratory physiology during the past decade is the discovery of the role of surface phenomena. This has been in large measure the result of pioneer work by Pattle, in England, and Clements, in the United States. The following is a simplified and brief review of present knowledge of surface tension, as it relates to normal and abnormal pulmonary function.