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Full-Text Articles in Medicine and Health Sciences

Comparison Of Crown Fracture And Wear Resistence Of Resin 3d Printed Permanent Crown And Other Restorative Materials, Victor Moncada Jan 2023

Comparison Of Crown Fracture And Wear Resistence Of Resin 3d Printed Permanent Crown And Other Restorative Materials, Victor Moncada

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Statement of Problem: The resin for 3D printing permanent crowns is a recently approved material with limited literature evidence to support its in vitro properties. Comparing the mechanical properties such as fracture load (N) and wear resistance for 3D printing permanent restorations resins would represent a very good reference to consider future clinical decisions. Purpose: To investigate the fracture load (N) and wear resistance of the resins for 3D printing permanent crowns available in the U.S. dental market and to compare amongst them using lithium disilicate as a reference. Materials and Methods: for the crown fracture test, the experimental design …


The Molecular And Structural Basis Of B Cell Epitope Targeting In Transplant Rejection, John T. Killian Jr Jan 2023

The Molecular And Structural Basis Of B Cell Epitope Targeting In Transplant Rejection, John T. Killian Jr

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HLA-reactive antibodies (HLA-Abs) to mismatched polymorphic HLA molecules are one of the major barriers to successful organ transplantation. However, key knowledge gaps remain surrounding the immunology of the anti-HLA B cell response in transplant rejection. This lack of understanding regarding the phenotype and specificity of the anti- HLA B cell response means that the field cannot develop optimal therapies to treat B-cell mediated donor-specific responses and that it lacks the tools to optimally match donors and recipients to prevent rejection events. Therefore, this dissertation aimed to explore the clinical factors associated with the formation of donor-specific antibodies and the molecular …


Lateral Ridge Augmentation Using Allograft Bone Particles Hydrated With Or Without Recombinant Human Platelet-Derived Growth Factor: A Clinical And Histological Randomized Controlled Trial, Lauren Miele Jan 2023

Lateral Ridge Augmentation Using Allograft Bone Particles Hydrated With Or Without Recombinant Human Platelet-Derived Growth Factor: A Clinical And Histological Randomized Controlled Trial, Lauren Miele

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Lateral ridge augmentation is a common procedure to increase the width of bone in preparation for a dental implant. A certain thickness of bone is necessary for implant health, making ridge augmentation procedures necessary for many patients. Research into the use of growth factors in ridge augmentation is ongoing, but few studies have examined the use of recombinant human platelet-derived growth factor homodimer (rhPDGF-BB) in ridge augmentation. This study examines histologic, clinical, and patient reported outcomes when horizontal ridge augmentation is completed using freeze dried bone allograft hydrated in rhPDGF-BB or saline and a resorbable crosslinked collagen membrane. Histologic results …


The Influence Of A Low Glycemic Load Diet On Appetite In Women With Pcos, Sarah Et Hoover Jan 2023

The Influence Of A Low Glycemic Load Diet On Appetite In Women With Pcos, Sarah Et Hoover

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Dysregulated appetite may contribute to weight gain and high prevalence of comorbid obesity in women with polycystic ovary syndrome (PCOS), yet dietary recommendations to promote satiety and facilitate weight maintenance in this population remain scarce. The objective of this dissertation was to determine if women with PCOS have alterations in appetite-regulating hormones that can be manipulated by low glycemic load diet habituation to improve satiety. This was tested by secondary analyses of two randomized controlled dietary intervention trials in women with and without PCOS. First, we explored differences in women with and without PCOS during a standardized liquid meal test …


Neural-Glial-Vascular Interactions In Human Outer Retina, Deepayan Kar Jan 2023

Neural-Glial-Vascular Interactions In Human Outer Retina, Deepayan Kar

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The outer retinal metabolic ecosystem is a complex interplay among photoreceptors, RPE and blood supply from the retinal and choroidal microcirculation. Breakdown of any component of this ecosystem has detrimental effects and can lead to cellular dysfunction. For example, in age-related macular degeneration a major cause of vision loss in older adults, breakdown of this metabolic unit has severe structural and functional implications. Thus, every feature and component of this ecosystem seems to be optimized to protect non-replicating, terminally differentiated cells from being damaged. Remarkably, much of the cellular and subcellular organization of this system is available for observation in …


Imaging Nanoscale Plasma Membrane Dynamics Reveals Diversity In Clathrin-Coated Vesicle Formation, Tomasz Jacek Nawara Jan 2023

Imaging Nanoscale Plasma Membrane Dynamics Reveals Diversity In Clathrin-Coated Vesicle Formation, Tomasz Jacek Nawara

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Clathrin-mediated endocytosis (CME) is an essential cellular process facilitating the internalization of a variety of cargo. Clathrin polymerization and changes in plasma membrane architecture and composition are necessary steps to mediate the formation of clathrin-coated vesicles (CCVs). However, simultaneous analysis of clathrin dynamics and membrane structure in living cells is challenging due to the limited axial resolution of fluorescence microscopes and the heterogeneity of CME. This has fueled conflicting models of vesicle assembly and obscured the roles of flat clathrin assemblies. Here we use Simultaneous Two-wavelength Axial Ratiometry (STAR) microscopy to bridge this critical knowledge gap by quantifying the nanoscale …


Modular Regulation And Function Of The Polypyrimidine Tract Binding Protein 1 (Ptbp1), Christine Carico Jan 2023

Modular Regulation And Function Of The Polypyrimidine Tract Binding Protein 1 (Ptbp1), Christine Carico

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RNA binding proteins (RBPs) are critical regulators of gene expression as they are responsible for the chaperoning and processing of every nascent RNA transcript. Many studies have investigated mechanisms of specificity of RBP function and have identified factors such as cell-specific expression of RBPs and differential preferences for RNA secondary structure. However, RBPs are often multi-domain proteins that contain repeats of various RNA binding domains (e.g., RNA recognition motif) and little work in the genomic era of transcriptomic interrogation has been done to define the contribution of individual domains to the overall protein function. Polypyrimidine tract binding protein 1 (PTBP1) …


Reduction Of Sphingomyelinases Associated With Progranulin Deficiency And Frontotemporal Dementia, Nicholas R. Boyle Jan 2023

Reduction Of Sphingomyelinases Associated With Progranulin Deficiency And Frontotemporal Dementia, Nicholas R. Boyle

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Frontotemporal dementia (FTD) is a leading cause of early-onset dementia and has a significant socioeconomic burden due to difficulties in diagnosis and delay to diagnosis. FTD is a clinically, pathologically, and genetically heterogeneous disorder. The pathological changes associated with FTD are termed frontotemporal lobar degeneration (FTLD). Protein aggregates are always present in FTLD, with >90% of cases presenting with either TDP-43 or tau pathology. Most cases of FTD are sporadic, but familial cases account for up to 25% of FTD. All familial FTD is inherited in an autosomal dominant fashion with most cases being caused by mutations in tau (MAPT), …


Maternal, Infant, And Early Childhood Home Visiting And School Readiness In Alabama, Heather H. Johnson Jan 2023

Maternal, Infant, And Early Childhood Home Visiting And School Readiness In Alabama, Heather H. Johnson

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This study examined the relationship between home visiting and school readiness in Alabama. Topics included a scoping review of the home visiting literature, statistical analyses of Alabama’s Teaching Strategies GOLD® (GOLD) data to determine if there were differences in performance among children who received home visiting compared to those who did not, and the development of a Key Driver Diagram (KDD) to inform improvement in home visiting practices that support school readiness. The scoping review of the literature indicated an absence of consistent definitions and measurement of the concept of school readiness. Through thematic analysis of the articles, contextual factors …


Quantitative Analysis Of The Impact Of Automatically Generated Normal Tissue Contours On Knowledge-Based Planning Model Quality, Samuel Christopher Baker Arnold Jan 2023

Quantitative Analysis Of The Impact Of Automatically Generated Normal Tissue Contours On Knowledge-Based Planning Model Quality, Samuel Christopher Baker Arnold

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While radiotherapy has become one of the primary standards of treatment for cancer in areas such as the brain, treatment plans are limited by the time it takes physicians to contour CT images used for dose distribution calculations. Automation of the contouring process can not only improve the rate of plan formation but establish an improved standard of care. With the development and implementation of knowledge-based planning (KBP) in radiation oncology, information derived from treatment plans provide machine learning models with years of experience to assess and create future treatment plans. Since KBP model quality rely on contouring from training …


Modifiable Risk Factors And Subsequent All-Cause And Cause-Specific Late Mortality After Blood Or Marrow Transplanta-Tion (Bmt), Nora Balas Jan 2023

Modifiable Risk Factors And Subsequent All-Cause And Cause-Specific Late Mortality After Blood Or Marrow Transplanta-Tion (Bmt), Nora Balas

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The objective of this dissertation was to examine the association between modifiable risk factors and subsequent all-cause and cause-specific late mortality among blood or marrow transplantation (BMT) recipients. I analyzed data for participants who were ≥18 years (y) at study participation from the BMT Survivor Study (BMTSS). BMTSS (U01 CA213140, PI: Bhatia) is a cohort study designed to examine the long-term outcome of individuals who survived ≥2y after undergoing BMT between 1974 and 2014, at the University of Alabama at Birmingham, City of Hope, or University of Minnesota. BMTSS also examines outcomes in an unaffected comparison group drawn from the …


An Examination Of The Relationship Between Mobile Apps And Healthcare Outcomes: A Patient Engagement And Patient Satisfaction Perspective, Khaled Hamad Alkhalifa Jan 2023

An Examination Of The Relationship Between Mobile Apps And Healthcare Outcomes: A Patient Engagement And Patient Satisfaction Perspective, Khaled Hamad Alkhalifa

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Background: Mobile apps are rapidly becoming an essential tool for hospitals to be competitive in a rapidly evolving healthcare market driven by patient expectations. The effectiveness of mobile apps is not fully understood, and more research needs to be done to evaluate their impact on patient satisfaction. More specifically, the role of patient engagement in this relationship needs to be investigated, given the rapid improvement in health behavior-changing mobile apps.Objective: This study aimed to examine (1) whether hospitals providing mobile apps are associated with higher patient satisfaction and patient engagement scores, (2) whether mobile app usability impacts this relationship, and …


Dact1, The “Super-Crosslinker”: Regulation Of Non-Canonical Wnt Signaling During Vertebrate Convergent Extension By Modulating Dishevelled Oligomerization, Allyson Angermeier Jan 2023

Dact1, The “Super-Crosslinker”: Regulation Of Non-Canonical Wnt Signaling During Vertebrate Convergent Extension By Modulating Dishevelled Oligomerization, Allyson Angermeier

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A broad spectrum of human birth defects arise from the disruption of morphogenesis, the critical process through which tissues and organs acquire their proper shape. Convergent extension (CE) is a universal morphogenetic engine that promotes polarized extension of diverse tissues and organs by regulating directional cell behavior, such as oriented cell intercalation. In vertebrates, CE is regulated by non-canonical Wnt/Planar Cell Polarity (PCP) pathway, an ancient signaling pathway that was originally discovered to coordinate the cellular polarity in the plane of the epithelium. Non-canonical Wnt/PCP signaling shares the Frizzled (Fz) receptor and cytoplasmic signal transducer Dishevelled (Dvl) with the canonical …


Chronic Circadian Disruption Increases Risk For Cardiovascular Disease, Jazmine I Benjamin Jan 2023

Chronic Circadian Disruption Increases Risk For Cardiovascular Disease, Jazmine I Benjamin

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Circadian disruption is a disturbance in biological timing which can occur within or between different organizational levels, ranging from molecular rhythms within specific cells to misalignment of behavioral and environmental cycles. Previous work has shown that changing the timing of food availability is sufficient to lower blood pressure and improve insulin sensitivity in prediabetic males, demonstrating the importance of timing of food intake for cardiovascular health. Findings from our group demonstrated that less than one week of mistimed feeding is sufficient to invert diurnal blood pressure rhythms, although kidney excretory rhythms and kidney function remained aligned with the light-dark cycle. …


Regulatory Elements Of Polyphosphate Biosynthesis, Marvin Qortez Bowlin Jan 2023

Regulatory Elements Of Polyphosphate Biosynthesis, Marvin Qortez Bowlin

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Polyphosphate (polyP) is an ancient, conserved, inorganic biomolecule. Biological systems have adapted many functions for this high-energy molecule, ranging from immune regulation in mammals to gene regulation in prokaryotes. Of particular interest is its use in bacterial stress responses. Bacteria use polyP to resist hazardous environmental elements like toxic molecules or nutrient starvation. In many bacterial species, polyP is synthesized by polyphosphate kinases (PPKs). PPK – discovered in Escherica coli (E. coli) – hydrolyzes adenosine-5’-triphosphate (ATP) to synthesize polyP. Species that use PPK develop multiple pathogenic defects when PPK activity is impaired, including, among others, antibiotic susceptibility. There is no …


Crucial Role Of T Follicular Helper Cell-Derived Ifn-Γ In Lung Resident Memory B Cell Responses, Nicole Michelle Arroyo-Diaz Jan 2023

Crucial Role Of T Follicular Helper Cell-Derived Ifn-Γ In Lung Resident Memory B Cell Responses, Nicole Michelle Arroyo-Diaz

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T follicular helper (Tfh) cells constitute a distinct subset of CD4 T cells that reside within B cell follicles, playing an indispensable role in orchestrating the Germinal Center (GC) response. In response to polarizing environments, such as Influenza A virus infection (IAV), Tfh cells secrete effector cytokines, including IFN-γ and IL-4. Nevertheless, the specific functions of cytokine-producing Tfh cell subsets, beyond their involvement in driving class switch recombination (CSR), remain largely unexplored. Here, we demonstrate that, following IAV infection, Tfh cell cytokine production undergoes a dynamic shift, transitioning from early IFN-γ dominance to later predominance of IL-4. The initial IFN-γ …


Understanding How Multi-Level Factors Influence Cancer Clinical Trial Enrollment Decisions By Patients Living In Higher Disadvantaged Areas, Nicole Caston Jan 2023

Understanding How Multi-Level Factors Influence Cancer Clinical Trial Enrollment Decisions By Patients Living In Higher Disadvantaged Areas, Nicole Caston

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Cancer clinical trials offer current patients with cancer new treatment and novel interventions to treat their cancer, while advancing the care of future patients. Clinical trials test new drugs against the standard of care to determine drug efficacy and safety. There are many groups of patients who are either unrepresented or underrepresented in cancer clinical trials and there is a plethora of reasons they are not represented. One underrepresented population of interest is patients with cancer who live in highly disadvantaged neighborhoods. Previous research found that when compared to patients who live in areas of lower disadvantage, patients living in …


Socioeconomic Challenges Of Long Covid, Justin Catt Jan 2023

Socioeconomic Challenges Of Long Covid, Justin Catt

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Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection or PASC, is a condition resulting from a SARS-CoV-2 infection characterized by continuing or novel symptoms across multiple organ systems occurring at least four weeks after infection. Symptoms of Long COVID can include cognitive impairment, memory loss, and fatigue. Although associations between COVID-19 and social determinants of health have been studied, noting that disadvantaged socioeconomic or racial groups have higher incidence and mortality rates from COVID-19, the associations between Long COVID and social determinants of health have not been robustly examined. Using data from the Household Pulse Survey in Summer …


I Would Be Shocked If Someone’S Not Depressed With That Diagnosis”: An In-Depth Exploration Of The Manifestation And Management Of Depression And Anxiety In Patients With Cancer, Carmen Rainey Brown Jan 2023

I Would Be Shocked If Someone’S Not Depressed With That Diagnosis”: An In-Depth Exploration Of The Manifestation And Management Of Depression And Anxiety In Patients With Cancer, Carmen Rainey Brown

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Patients diagnosed with cancer experience depression and anxiety at higher rates compared to the general population. Most individuals diagnosed with cancer will experience symptoms of depression and anxiety at some point during their cancer trajectory and not seek care leaving their mental health conditions undiagnosed and untreated, which impact quality of life and cancer outcomes. Patient and providers perspectives are vital to understand the manifestation, care-seeking behaviors, and provider management of depression and anxiety in patients with cancer. This study sought to explore the manifestation of depression and anxiety among patients with cancer and their care seeking behaviors for mental …


Temporal Trends In Tularemia Incidence In The United States From 2010 To 2020. Are Age And Sex Associated With These Changing Trends?, Carla V. Brooks Jan 2023

Temporal Trends In Tularemia Incidence In The United States From 2010 To 2020. Are Age And Sex Associated With These Changing Trends?, Carla V. Brooks

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Background: Tularemia or Rabbit Fever was discovered in 1911 in a plague-like outbreak among rodents in Tulare County, California. Tularemia in the US has expanded from rural to more metropolitan areas, which may be potentially correlated with the escalating exposure of humans to animal vectors. There has not been a recent study evaluating trends in Tularemia, especially one that has evaluated if the trends in Tularemia over time differ by demographic characteristics. Methods: This is an ecological study to evaluate the temporal trends and if trends Tularemia incidence over time differs by age and sex in the United States from …


Antimicrobial Resistance In Type Ii Diabetic Patients In Southeastern U.S., Onyebuchi Angela Elegede Jan 2023

Antimicrobial Resistance In Type Ii Diabetic Patients In Southeastern U.S., Onyebuchi Angela Elegede

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Background: In the Southern and Appalachian regions of the United States, antibiotic prescription rates surpass the national average, coinciding with a higher prevalence of Type II diabetes (DM2). Although international research has previously described the correlation between DM2 and increased risk of antimicrobial-resistant (AMR) infections, comprehensive studies on this relationship are lacking in the U.S. The objective of this study was to investigate the association between AMR infections and DM2 and examine the association in two DM2 positive racial groups. This study also examined the differences in the prevalence of clindamycin resistance of methicillinresistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus …


Effects Of Light Curing Bonding Agent With Dual Cure Cement On The Retention Of Zirconia And Lithium Disilicate Crowns: An In-Vitro Study., Mariam Issa Jan 2023

Effects Of Light Curing Bonding Agent With Dual Cure Cement On The Retention Of Zirconia And Lithium Disilicate Crowns: An In-Vitro Study., Mariam Issa

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Objective: To measure and compare the bond strength of zirconia and lithium disilicate crowns bonded to human teeth (enamel and dentin) using universal adhesive with resin cement and different light curing protocols.Methods: Sixty extracted sound non carious human teeth (second premolars) were stored in formalternate solution (FormalternateTM, Concentrate, 500 mL, Canada) and the roots were notched and mounted into acrylic resin (Yates Motloid, USA). Flat surface preparation was done on the occlusal surface of the samples using model trimmer. The surface area of the specimens was measured with digital light microscopy. Samples were randomly divided into six groups of 10 …


Impact Of Exercise On Antioxidative-Stress Induced Endoplasmic Reticulum Dysfunction And Cardiac Remodelling, Arun Jyothidasan Jan 2023

Impact Of Exercise On Antioxidative-Stress Induced Endoplasmic Reticulum Dysfunction And Cardiac Remodelling, Arun Jyothidasan

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The gain of function of nuclear factor erythroid 2 like 2 (Nrf2), in the absence of oxidative stress (or toxic insults), its pathophysiology arising from the endoplasmic reticulum and exercise intervention to mitigate the pathology are the focal point of this dissertation. Nrf2, when constitutively expressed, has been previously associated with cardiomyopathy. Chapter II investigated the hypothesis that cardiac-specific expression of Nrf2 (mNrf2-TG) would establish a pro-reductive state and trigger adaptive cardiac remodeling by enhancing the basal antioxidant defense. Through RNA profiling and imaging techniques, the study underscored that while acute preconditioning might prove advantageous against oxidative stress, prolonged pro-reductive …


Challenges And Opportunities In Glioblastoma And Immunovirotherapy With Oncolytic Herpes Simplex Virus Type 1, Dagoberto Estevez-Ordonez Jan 2023

Challenges And Opportunities In Glioblastoma And Immunovirotherapy With Oncolytic Herpes Simplex Virus Type 1, Dagoberto Estevez-Ordonez

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This dissertation covers data from published and pre-published studies exploring challenges and opportunities in the treatment of malignant glioma with emphasis in glioblastoma and oncolytic immunovirotherapy with an oncolytic herpes simplex virus type 1 (HSV-1) designed to induce expression of IL-12, M002 (murine IL-12) and M032 (human IL-12).It starts with the report of a study that uncovered important racial and socioeconomic disparities experienced by patients with glioblastoma treated in Alabama. Notable results also include the unexpected finding of increased survival in African American patients with glioblastoma even after controlling for factors associated with survival and socioeconomic disparities. The implications of …


Parenting Through A Pandemic: A Mixed Methods Analysis Of Covid-19’S Impact On Stress, Coping, Resiliency, And Mental Health Among University Student-Parents, Jordin Ann Lane Jan 2023

Parenting Through A Pandemic: A Mixed Methods Analysis Of Covid-19’S Impact On Stress, Coping, Resiliency, And Mental Health Among University Student-Parents, Jordin Ann Lane

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The COVID-19 pandemic has taken a toll on the mental health of university students and continues to have a profound impact to this day. The transition from in-person traditional courses to online courses and campus closures, coupled with feelings of isolation, fear of contracting COVID-19, and uncertainty of the future has further intensified the mental health of college students. The effects of federal and state regulations, such as stay-at-home orders, influenced the mental health and general well-being of many Americans, specifically those who take on a dual role as a student and a parent. Unfortunately, literature pertaining to the effects …


Time-Restricted Feeding Attenuates Obesity-Induced Muscle Dysfunction Through Energy Metabolism And Microbiota Modulation, Chris Livelo Jan 2023

Time-Restricted Feeding Attenuates Obesity-Induced Muscle Dysfunction Through Energy Metabolism And Microbiota Modulation, Chris Livelo

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Obesity is a global epidemic that affects countless numbers of people caused by genetic and environmental factors including circadian disruption, which poses significant health risks to skeletal muscle physiology and other tissues. While a feeding fasting intervention known as time-restricted feeding (TRF) has been shown to mitigate obesity-related muscle dysfunction, the underlying mechanisms remain a subject of investigation. In this study, we delve into potential mechanisms underlying TRF's protective effects on muscle physiology in the context of diet- and genetic-induced obesity using Drosophila models. Our findings reveal that TRF triggers the upregulation of key genes involved in glycine production (Sardh …


Accuracy Of "Reading" Untraced Lateral Cephalometric Radiographs Among Practicing Orthodontists, Shannon Rea Jan 2023

Accuracy Of "Reading" Untraced Lateral Cephalometric Radiographs Among Practicing Orthodontists, Shannon Rea

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Objective: To determine if orthodontic clinicians are able to ascertain diagnostic information from untraced lateral cephalometric radiographs. Materials and Methods: A survey consisting of 5 cases was presented to practicing orthodontists. Each case presented a lateral cephalometric radiograph and included ten questions requiring the respondent to make clinical judgments and approximations of the following variables: skeletal classification, maxilla and mandibular skeletal relationship, SNA, SNB, ANB, vertical skeletal classification, FMA, molar relationship, maxillary incisor proclination, and mandibular incisor proclination. 46 responses were collected and analyzed. Results: Case 3, the normodivergent, Skeletal Class I patient had the highest percentage of correct answers …


Identifying The Factors Influencing Hiv Testing And Safe Sex Practices: An Ecological Approach, Shekwonya Evelyn Samuel Jan 2023

Identifying The Factors Influencing Hiv Testing And Safe Sex Practices: An Ecological Approach, Shekwonya Evelyn Samuel

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Introduction: HIV (Human Immunodeficiency Virus) is a sexually transmitted infection (STI) that is still a major health issue in the United States and the world. Emerging adults are more likely to engage in risky sexual behaviors such as multiple sexual partners and unprotected sex. HIV testing contributes to ending the HIV epidemic by identifying at-risk individuals and promoting early diagnosis.Methods: Secondary data analyses of the City Health II dataset were conducted to 1) identify the association between HIV testing and risky sexual behaviors among Black/African American emerging adults ages 18-25 years living in Birmingham metro area, 2) use social network …


Comparison Of Radiological Signs To Clinical Symptoms In Children With Jia. A Pilot Study, Shubham Sharma Jan 2023

Comparison Of Radiological Signs To Clinical Symptoms In Children With Jia. A Pilot Study, Shubham Sharma

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JIA, which stands for juvenile idiopathic arthritis, is a group of chronic inflammatory joint diseases that usually occur in children under the age of 16 and last for at least six weeks1–5. It is one of the most common chronic joint diseases in childhood1 and affects up to 150 out of every 100,000 children worldwide6. This condition has no identifiable cause and is different from adult rheumatoid arthritis. Unfortunately, JIA can have a significant negative impact on the lives of these young children, causing disability and impairing their daily activities. TMJ involvement is more common than previously believed in JIA …


Comparison Of Flexural Strength, Fracture Toughness, And Color Stability Of Cad/Cam 3d-Printed Denture Base Materials To Milled And Conventional Heat-Polymerized Materials: An In Vitro Study, Yamen Safadi Jan 2023

Comparison Of Flexural Strength, Fracture Toughness, And Color Stability Of Cad/Cam 3d-Printed Denture Base Materials To Milled And Conventional Heat-Polymerized Materials: An In Vitro Study, Yamen Safadi

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Digitalization of the design and manufacturing of complete dentures streamlines the clinical and laboratory processes and provides increased efficiency and enhanced denture quality.[1, 2] The two most common CAD/CAM techniques for denture base manufacturing are additive (3D-printing) and subtractive (milling) manufacturing. Milled denture bases have been proven to be comparable in their physical and mechanical properties to conventional heat-polymerized denture bases,[3-6] and in many studies found to be superior to 3D-printed denture bases.[7-13] However, 3D-printing offers many advantages over milling that appeal to both clinicians and dental technicians related to investment and operational costs, maintenance, speed of manufacturing, diversity of …