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Articles 1 - 30 of 135
Full-Text Articles in Medicine and Health Sciences
Risk Factors For Stroke In Rural African Americans And Factors That Influence Exercise Behaviors To Reduce Stroke Risk, Dawn M. Aycock
Risk Factors For Stroke In Rural African Americans And Factors That Influence Exercise Behaviors To Reduce Stroke Risk, Dawn M. Aycock
All ETDs from UAB
Stroke has increased among young adults, which is concerning for African Americans (AA) who tend to have stroke at an earlier age and an increased risk for mortality and severe disability. Rural dwellers lack resources which may increase their susceptibility to stroke. Regular exercise can reduce stroke; however, physical activity among AA is low. The purpose of this research was to use an Expanded Health Belief Model to examine perceived and actual stroke risk among rural AA 19 to 54 years of age and factors that influence exercise behaviors to reduce stroke risk. A cross-sectional correlational design was used. Participants …
A Pilot Study To Determine The Effectiveness Of Bioelectrical Impedance Analysis As A Clinical Assessment Tool Of Nutrition Status In Glioblastoma Multiforme Patients (The Beam Study [Bia Effectiveness As Assessment Tool For Gbm Patients]), Rebecca V. Barnhill
All ETDs from UAB
Glioblastoma multiforme (GBM) is a rare brain tumor, yet accounts for 80% of malignant brain tumors and has a five-year survival rate of < 5%. Few studies have evaluated nutrition recommendations and outcomes of this disease, including caloric needs. The purpose of this study was to find the best predictive equation for resting energy expenditure (REE) for GBM patients and evaluate bioelectrical impedance analysis (BIA) as a clinical tool for estimating REE and fat free mass (FFM) of GBM patients. REE was measured with indirect calorimetry. FFM was measured with DXA and estimated with BIA. Published predictive equations for REE were calculated to compare to measured REE. Six equations used variables easily attained in a clinical setting and three used FFM. Correlation analysis was used to evaluate the strength of the relationships between measured and predicted REE. Agreement between methods on the group level was assessed by comparing the group means of measured and predicted REE with paired t-tests. The Bland-Altman approach was used to find agreement between the methods on the individual level. Analysis included fifteen newly diagnosed GBM patients (7 male and 8 female; mean age 57.1±11.6 years) to evaluate equations using clinical variables and a subsample of eight to evaluate predictive equations using FFM. All the predictive equations overestimated measured REE. The Mifflin-St Jeor was the only equation using clinical variables which was not significantly different from measured REE (p=0.054) and had the lowest bias (73 kcal/day) and narrowest limits of agreement. Likewise, Cunningham and Wang equations using FFM from DXA were not significantly different from measured (p=0.261 and p=0.072, respectively). BIA overestimated FFM compared to DXA, 54.1 kg and 49.2 kg, respectively (p<0.001). More visits with both DXA and BIA measurements available are needed before predictive equations with clinical variables and predictive equations with FFM can be compared. Due to the ease of obtaining clinical variables and the low bias and narrow limits of agreement found for the Mifflin equation, at this time it appears to be the best predictive equation for individuals with GBM.
Social Connectedness And Its Association With Violence Commission In Adolescents Living In Low-Income Inner-City Neighborhoods, Thomas Norton Creger
Social Connectedness And Its Association With Violence Commission In Adolescents Living In Low-Income Inner-City Neighborhoods, Thomas Norton Creger
All ETDs from UAB
ABSTRACT For nearly two decades, violence has been viewed as a major public health issue. According to the Centers for Disease Control and Prevention, 4,141 young people between the ages of 10 and 19 were murdered in 2008, and over 480,238 young people were treated for violence-related injuries in U.S. emergency rooms that same year. That translates to an average of 11 young people murdered each day, and a daily average of 1,315 young people who sustained violence-related injuries so severe that they required treatment at a hospital. The purpose of this study was to test a multilevel model linking …
Studies In Public Health Systems And Services Research: Three Papers Examining The Market Environment, Quality Improvement, And Community Partnerships, Valerie A. Yeager
Studies In Public Health Systems And Services Research: Three Papers Examining The Market Environment, Quality Improvement, And Community Partnerships, Valerie A. Yeager
All ETDs from UAB
This dissertation, comprised of three publishable manuscripts, addresses various identified gaps in the literature focused on public health systems and services research. Public health systems and services research includes studies that examine the organization, financing and delivery of public health services in communities, and the impact of these services on public health. Specifically, this dissertation focuses on three topics: (1) the measurement of the health care market environment of local public health departments, (2) community characteristics related to quality improvement strategies in local public health environments, and (3) the longitudinal changes in public health partnerships and how these partnerships relate …
Using Mouse Models To Investigate Ciliopathies, Raymond Carl Pasek
Using Mouse Models To Investigate Ciliopathies, Raymond Carl Pasek
All ETDs from UAB
Cilia and flagella are microtubule based organelles found on nearly every cell type in the mammalian body. Flagella have an essential role in sperm locomotion and reproduction, while motile cilia have a known role in fluid movement in the brain, lungs, and portions of the female reproductive tract. While the role of most primary cilia remained unknown for decades, they are now recognized as being essential to mammalian development, renal homeostasis, and satiety, just to name a few. Because of their widespread presence and importance, dysfunction of cilia and flagella can lead to a variety of human diseases, collectively referred …
Socioeconomic Patterning Of Obesity Among African American Women In The Jackson Heart Study, Tonya Moore
Socioeconomic Patterning Of Obesity Among African American Women In The Jackson Heart Study, Tonya Moore
All ETDs from UAB
Objectives: The purpose of this study was to expand upon what has been observed in literature about obesity and its ties to socioeconomic status (SES) among African American Women (AAW) participants of the Jackson Heart Study (JHS). Methods: This secondary analysis was a sub-study of the JHS and focused on four SES variables: education, income, occupation and wealth; and five outcome variables: body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT). Two analytic samples were created in order to examine data collected during Exam 1 (2000-2004) and Exam 2 (2005-2008). …
Diagnostic Classifications For Bipedal Locomotion, Lois Deming Hedman
Diagnostic Classifications For Bipedal Locomotion, Lois Deming Hedman
All ETDs from UAB
Background: Analysis of and intervention for movement dysfunction, especially walking dysfunction, is the central expertise of physical therapists (PTs). PTs are called to establish a diagnosis prior to making patient management decisions yet no valid classification system for walking exists. Objectives: The purpose of this study was to determine if locomotor experts could arrive at consensus on the validity, mutual exclusivity and understandability of diagnostic classifications for bipedal locomotion. Methods: An electronic mail Delphi survey methodology was utilized. Experts were recruited purposefully through research and clinical leaders in the PT profession. Identified experts were then asked for their recommendations in …
Factors Associated With Participant Retention In A Behavioral Weight Loss Study, Cathy C. Roche
Factors Associated With Participant Retention In A Behavioral Weight Loss Study, Cathy C. Roche
All ETDs from UAB
Participant retention in longitudinal research is gaining increasing attention. By identifying factors associated with participant retention, programs can be better designed to promote effective weight loss. This study examines factors associated with participant retention. The Anderson Behavioral Model provided the conceptual framework for the study. The sample consisted of secondary data abstracted from the research records of 316 participants in the University of Alabama at Birmingham cohort of the Look Action for Health in Diabetes (AHEAD) trial. The Look AHEAD trial is a randomized controlled trial designed to investigate the long-term effects of interventions aimed at producing weight loss in …
Hepatic Effect Of Inhaled Ozone In Sprague-Dawley Rat, Whitney Slone Theis
Hepatic Effect Of Inhaled Ozone In Sprague-Dawley Rat, Whitney Slone Theis
All ETDs from UAB
Ozone (O3) is a primary component of photochemical smog and represents a serious public health concern as more than 50% of the U.S. population lives in areas exceeding national ambient air quality standards for this toxic pollutant. Recent findings indicate that the effects of inhaled O3 extend to extra-pulmonary tissues like the heart and liver. We hypothesize that inhaled O3 exposure-related events in the lung will cause downstream alterations in the liver proteome. To test this, we exposed male Sprague-Dawley rats to 0.5 ppm ozone for 8 hr a day for 5 days. After exposures, livers were removed and proteomic …
The Effect Of Structured Background On Smooth Pursuit With Real And Simulated Central Scotoma, Thomas Keith
The Effect Of Structured Background On Smooth Pursuit With Real And Simulated Central Scotoma, Thomas Keith
All ETDs from UAB
The purpose of the study was to better understand the role of the fovea in smooth pursuit eye movements in human subjects. The research entailed a systematical study of a previously unstudied condition where the foveal inputs of both the background and the pursuit target were eliminated through simulation but the anatomic fovea was intact; and a comprehensive study of smooth pursuit eye movements of human subjects with real central scotoma. Ten normally sighted subjects (NS) and three central scotoma subjects (CS) were asked to visually pursuit a 0.87o yellow dot moving along either a horizontal or a vertical trajectory …
An Exploration Of Factors Associated With Pre-Diabetes In The Reasons For Geographic And Racial Differences In Stroke (Regards) Study Cohort, Loretta Taylor Lee
An Exploration Of Factors Associated With Pre-Diabetes In The Reasons For Geographic And Racial Differences In Stroke (Regards) Study Cohort, Loretta Taylor Lee
All ETDs from UAB
Pre-diabetes is a major contributor to increased morbidity and mortality in the US. Without proper and timely intervention the majority of individuals with pre-diabetes will develop Type 2 diabetes. African Americans (AA) and people living in the Stroke Belt have increased odds of developing pre-diabetes compared to Whites and people living outside the Stroke Belt. While several covariates have been identified as contributors to the increased odds of pre-diabetes there is little consensus on which covariates may be responsible for the disparities of pre-diabetes. The reasons for disparities in pre-diabetes are complex and require further investigation. This study explored the …
Measuring Disease Activity And Use Of Complementary And Alternative Medicine In African-Americans With Rheumatoid Arthritis, Ashutosh Tamhane
Measuring Disease Activity And Use Of Complementary And Alternative Medicine In African-Americans With Rheumatoid Arthritis, Ashutosh Tamhane
All ETDs from UAB
The aims of this project were to: 1) compare disease activity scores 28 joints (DAS28) based on erythrocyte sedimentation rate (ESR) versus that based on C-reactive protein (CRP), and 2) describe prevalence of complementary and alternative medicine (CAM) use and examine differences of CAM use stratified by disease duration and sex. This analysis included participants from the Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis (CLEAR) Registry. Using tender and swollen joint counts separate ESR-based and CRP-based DAS28 scores (DAS28-ESR3 and DAS28-CRP3) were calculated, as were DAS28-ESR4 and DAS28-CRP4, which included the patient¡¯s assessment of disease …
Characterization Of Pleiotrophin And Receptor Protein Tyrosine Phosphatase Beta/Zeta In Odontoblast And Osteoblast Cell Lines, Amena Tamkenath
Characterization Of Pleiotrophin And Receptor Protein Tyrosine Phosphatase Beta/Zeta In Odontoblast And Osteoblast Cell Lines, Amena Tamkenath
All ETDs from UAB
Pleiotrophin (PTN) is an extracellular matrix-associated growth factor and chemokine expressed in mesodermal and ectodermal cells. It plays an important role in osteoblast recruitment and differentiation. PTN has two well-known physiological receptors, protein tyrosine phosphatase beta/zeta (RPTPRZ1), and N-syndecan. Protein tyrosine phosphatases are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins. Protein tyrosine phosphorylation is a common post-translation modification that can create novel recognition motifs for protein interactions and cellular localization, affect protein stability and regulate enzyme activity. Osteoblasts have recently been found to express the short transmembrane isoform of RPTP beta/zeta but nothing …
Regulatory T Cells In The Fvb.Mdr1a-/- Model Of Colitis, Scott Tanner
Regulatory T Cells In The Fvb.Mdr1a-/- Model Of Colitis, Scott Tanner
All ETDs from UAB
Regulatory T cells (Treg) are necessary for the maintenance of immune homeostasis, and have been implicated in several autoimmune diseases, including inflammatory bowel disease (IBD). Most murine studies focusing on the function of Tregs have been done on the C57BL/6 or BALB/c background, creating a bias towards these two strains. In addition, it has been shown that C57BL/6 and BALB/c Tregs function in different manners. To further investigate potential strain differences in Treg phenotype and function, we chose to analyze FVB/N Tregs. Several differences were observed, including de-creased FVB/N Treg suppression in a non-cell contact dependent manner, decreased FVB/N and …
The Impact Of Community Health Centers On Prostate Cancer Screening Behaviors Of African American Males: A Mixed Methods Study, Michael C. Taylor
The Impact Of Community Health Centers On Prostate Cancer Screening Behaviors Of African American Males: A Mixed Methods Study, Michael C. Taylor
All ETDs from UAB
THE IMPACT OF COMMUNITY HEALTH CENTERS ON PROSTATE CANCER SCREENING BEHAVIORS OF AFRICAN AMERICAN MALES: A MIXED METHODS STUDY MICHAEL C. TAYLOR UAB SCHOOL OF PUBLIC HEALTH DEPARTMENT OF HEALTH BEHAVIOR ABSTRACT Federally qualified community health centers have a significant impact upon uninsured and low income populations in the United States by providing low cost primary care and preventive services. The purpose of this mixed methods study was to determine the impact of community health centers (CHCs) on African American males' prostate cancer screening behavior in a major Southern city. A sequential explanatory mixed method model was used to assess …
Hepatic Effect Of Inhaled Ozone In Sprague-Dawley Rat, Whitney Slone Theis
Hepatic Effect Of Inhaled Ozone In Sprague-Dawley Rat, Whitney Slone Theis
All ETDs from UAB
Ozone (O3) is a primary component of photochemical smog and represents a serious public health concern as more than 50% of the U.S. population lives in areas exceeding national ambient air quality standards for this toxic pollutant. Recent findings indicate that the effects of inhaled O3 extend to extra-pulmonary tissues like the heart and liver. We hypothesize that inhaled O3 exposure-related events in the lung will cause downstream alterations in the liver proteome. To test this, we exposed male Sprague-Dawley rats to 0.5 ppm ozone for 8 hr a day for 5 days. After exposures, livers were removed and proteomic …
Sleep Duration And Obesity: Longitudinal Study Of Adolescents, Herpreet Kaur Thind
Sleep Duration And Obesity: Longitudinal Study Of Adolescents, Herpreet Kaur Thind
All ETDs from UAB
Prevalence of obesity continues to be high in the United States with about one-third adults being overweight or obese. Among adolescents the rates of overweight/obesity have increased by three times in the past two decades. Moreover, the rates of obesity are disproportionately high among the minority population. Recently, sleep duration has emerged as an independent risk factor for obesity. Several cross-sectional and longitudinal studies worldwide have shown an inverse relationship between sleep duration and obesity. However, some studies do not support this association. Majority of the studies in the United States have been conducted on predominantly White populations. African Americans …
The Role Of St6gal-I Sialylation In Fas (Cd95) Death Receptor Function And Tumorigenesis, Amanda F. Swindall
The Role Of St6gal-I Sialylation In Fas (Cd95) Death Receptor Function And Tumorigenesis, Amanda F. Swindall
All ETDs from UAB
The golgi glycosyltransferase, ST6Gal-I, adds a negatively-charged sialic acid in an alpha-2-6 linkage to N-linked glycans. ST6Gal-I is upregulated in many cancers, and is associated with increased metastasis and poor patient prognosis. ST6Gal-I expression has been shown to be driven by oncogenic-ras signaling. However, mechanistic details of the role ST6Gal-I plays in tumor initiation and progression are not well defined. Historically, studies have focused on contributions of ST6Gal-I to the malignant cell phenotypes of migration and invasion. Emerging evidence including studies contained in this dissertation have begun to elucidate a role for ST6Gal-I as a regulator of apoptotic signaling by …
Cardiovascular Disease Knowledge And Risk Perception Among Women With Recent Preeclampsia: Interventional Education In Disease Management And Prevention, Patsy M. Spratling
Cardiovascular Disease Knowledge And Risk Perception Among Women With Recent Preeclampsia: Interventional Education In Disease Management And Prevention, Patsy M. Spratling
All ETDs from UAB
There is a growing body of evidence linking preeclampsia to future development of cardiovascular disease (CVD). Although CVD is well-known as the leading cause of death in women, a lack of evidence exists demonstrating that women with preeclampsia are routinely informed of their risks for future CVD. The specific aims of this study were to: (1) examine the levels of CVD knowledge and perception of CVD risk pre-CVD education; (2) explore relationships among age, race, parity, marital status, previous preeclampsia, income, education, CVD knowledge, and perception of CVD risk; and (3) examine the effect of a postpartum CVD educational intervention …
A Role Of Angiogenin In Models Of Parkinson's Disease, Trent Steidinger
A Role Of Angiogenin In Models Of Parkinson's Disease, Trent Steidinger
All ETDs from UAB
Parkinson's Disease (PD) is the most common neurodegenerative movement disorder and is characterized by the loss of dopaminergic neurons in the substantia nigra. Gene multiplication of alpha-synuclein causes an autosomal dominant inheritance pattern of PD. A mouse model overexpressing alpha-synuclein demonstrates some of the phenotype seen in PD. In a microarray of these mice, a downregulation of angiogenin was observed prior to symptom onset, demonstrating a potential link of angiogenin to pathology in this model. Angiogenin has also been associated with the onset of Amyotrophic Lateral Sclerosis (ALS), and is neuroprotective in models of ALS through activation of the Akt …
The Hypometabolic Actions Of Hydrogen Sulfide In Mammalian Systems, Asaf Stein
The Hypometabolic Actions Of Hydrogen Sulfide In Mammalian Systems, Asaf Stein
All ETDs from UAB
In recent years, hydrogen sulfide (H2S) has been identified as a ubiquitous cell signaling molecule. In addition to its diverse physiological roles, H2S has emerged as a possible drug therapy, with a wide range of applications. Along with cytoprotective effects in pathological states such as ischemia-reperfusion injury, H2S has been shown to decrease aerobic metabolism in a reversible manner. This dissertation is focused on exploring H2S-induced hypometabolism and the implications therein for human health and disease. We have shown that rats exposed to 80 ppm H2S gas in combination with low oxygen (10.5% O2) for 6 hr exhibit decreases in …
Myosin Ii Regulates Actin Dynamics Critical For Structural Plasticity And Fear Memory Formation, Cristin Gavin
Myosin Ii Regulates Actin Dynamics Critical For Structural Plasticity And Fear Memory Formation, Cristin Gavin
All ETDs from UAB
Dynamic changes to the actin cytoskeleton are required for synaptic plasticity and long-term memory formation. However, the molecular mechanisms that mediate filamentous actin (F-actin) dynamics during both activity-dependent synaptic potentiation and long-term memory encoding are poorly understood. Myosin II motor proteins are highly expressed in actin-rich growth structures in neurons, including dendritic spines. Recent work demonstrates that these molecular machines mobilize F-actin in response to synaptic stimulation and are required for memory encoding in CA1 hippocampus of rodents. The aims of this project were two-fold. First, we sought to establish if myosin II regulates actin filament polymerization necessary for structural …
Sleep Quality, Stress, Caregiver Burden, And Quality Of Life In Maternal Caregivers Of Young Children With Bronchopulmonary Dysplasia, Christine A. Feeley
Sleep Quality, Stress, Caregiver Burden, And Quality Of Life In Maternal Caregivers Of Young Children With Bronchopulmonary Dysplasia, Christine A. Feeley
All ETDs from UAB
Mothers are usually the primary caregivers of young children with a chronic illness such as bronchopulmonary dysplasia (BPD), and may have no formal caregiver training. Children with BPD often require complex healthcare at home (complex medication regimens, oxygen via nasal cannula, Gastrostomy feedings, etc.), thus many maternal caregivers experience difficulty balancing the needs of their child with their own needs and other responsibilities. As such, maternal caregivers may report increased levels of stress and caregiver burden, as well as decreased quality of life (QOL). Additionally, a great number of maternal caregivers report poor sleep quality due to nighttime caregiving duties. …
Distribution/Localization And Relative Quantitation Of C-Terminal Αa-Crystallin Truncation Products Within Lenses Of Icr/F Rats Treated With Dietary Supplemented Genistein, Kyle Anthony Floyd
Distribution/Localization And Relative Quantitation Of C-Terminal Αa-Crystallin Truncation Products Within Lenses Of Icr/F Rats Treated With Dietary Supplemented Genistein, Kyle Anthony Floyd
All ETDs from UAB
The ocular lens functions to focus light coming into the eye onto the retina. Lens development begins in utero, and continues over an individual's lifetime. Lens fiber cells and their proteins are only synthesized once and have no repair mechanisms, so they remain for an individual's lifetime. The α-crystallins, the most abundant lens proteins, act as chaperones to keep damaged/unfolded proteins in-solution. Cataract disease is associated with protein damage, leading to a light scattering opacity. It has been suggested that truncation of αA-crystallin leads to a loss of chaperone function. Cataract disease is the leading cause of blindness in the …
Are Enabling Services In Federally Qualified Health Centers Associated With Women Receiving Prenatal Care In The First Trimester?, Forrest A. Daniels
Are Enabling Services In Federally Qualified Health Centers Associated With Women Receiving Prenatal Care In The First Trimester?, Forrest A. Daniels
All ETDs from UAB
The purpose of this study was to examine whether enabling services in federally qualified health centers (FQHCs) were associated with women receiving prenatal care services in the first trimester. The population for this study included FQHCs providing prenatal care services for the years 2008, 2009, and 2010. Data for this study were derived from two sources: Uniform Data System (UDS) and the Area Resource File (ARF). This study adopted the Andersen's (1973) Behavioral Model of Health Services Use. The study consisted of longitudinal panel data analysis. Univariate and bivariate statistics were calculated using PASW/SPSS statistical software, version 18. For the …
Scaffold-Mediated Size Determination Of Bacteriophage Capsids By Mobile Genetic Elements, Altaira Davida Dearborn
Scaffold-Mediated Size Determination Of Bacteriophage Capsids By Mobile Genetic Elements, Altaira Davida Dearborn
All ETDs from UAB
Bacteriophage can mediate the transfer of unrelated mobile genetic elements (MGE) from a carrier bacterial cell to the susceptible population around it. This transfer results in the spread of virulence or other accessory genes encoded on the MGE. During viral particle assembly, the MGE can discourage the formation of viable bacteriophage progeny by limiting the size of the particles to those large enough to encapsidate the MGE, but too small to fit the complete bacteriophage genome which is three times larger. Here, I present models for size determination by an external scaffolding protein which is independent of and dominant over …
Physical Activity Barriers Following Traumatic Brain Injury: A Cognitive Mapping Study, Anna De Joya
Physical Activity Barriers Following Traumatic Brain Injury: A Cognitive Mapping Study, Anna De Joya
All ETDs from UAB
Background: Despite the strong evidence indicating the benefits of regular physical activity (PA) for health and functioning, individuals with a traumatic brain injury (TBI) do not engage in PA at levels consistent with public health recommendations. To eliminate the health disparities and promote PA in this population, the barriers unique to individuals with TBI should be identified by different stakeholders to establish effective health promotion programs that have sustainable outcomes. There is limited evidence to guide the development and delivery of effective PA interventions in the TBI field. Objectives: The specific aims of this study are: 1) to identify the …
The Effect Of Liver X Receptor Α Deficiency In Skeletal Muscle On Lipid Content In Mice, Yishu Ding
The Effect Of Liver X Receptor Α Deficiency In Skeletal Muscle On Lipid Content In Mice, Yishu Ding
All ETDs from UAB
Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. Many researchs focus on the liver, but tissue-specific roles of LXRs in other tissues remain elusive. Based on in vitro studies on cultured cells, the roles of LXRs in skeletal muscle have been proposed. Nevertheless, the in vivo roles of LXRs in skeletal muscle remain lacking. Skeletal muscle is an important insulin targeting tissue, which plays a key role in regulating insulin sensitivity. Abnormal lipid metabolism and homeostasis have been demonstrated to play a crucial role in the development of insulin resistance in skeletal muscle. To …
Structural And Molecular Studies Of Nucleic Acid Chaperones, Lei Ding
Structural And Molecular Studies Of Nucleic Acid Chaperones, Lei Ding
All ETDs from UAB
Nucleic acids are the storage of genetic information that needs to be expressed and inherited. As abundant cellular macromolecules they are also major players of a wide variety of biological processes. They usually undergo post-transcriptional modifications and/or fold into higher order structures in order to accomplish their distinct functions. Most biological events involving nucleic acids are achieved by proteins that interact with them. The functionality requires specific recognition of nucleic acids by proteins at molecular level. Nucleic acid chaperones are a group of nucleic acids binding proteins that associate with structured RNAs or DNAs and assist correct folding of their …
Fat Distribution And Metabolic Health: The Effects Of Macronutrient Manipulation On Fat Distribution, Weight Loss, And Glucose Metabolism, Amy Miskimon Goss
Fat Distribution And Metabolic Health: The Effects Of Macronutrient Manipulation On Fat Distribution, Weight Loss, And Glucose Metabolism, Amy Miskimon Goss
All ETDs from UAB
Fat distribution pattern may contribute to risk of development of metabolic diseases such and type 2 diabetes and cardiovascular disease. However, the precise nature of the relationships between adipose tissue depots and metabolic health remains controversial. Additionally, further research is needed to identify optimal dietary approaches to reduce disease risk and visceral adiposity among overweight and obese individuals, who may already be on a trajectory for development of metabolic disease. Therefore, the goal of this project was to examine relationships of adipose tissue depots with insulin sensitivity, and then to determine if diets differing in CHO and fat content can …